MCID: BLM002
MIFTS: 62

Bulimia Nervosa malady

Neuronal diseases category

Summaries for Bulimia Nervosa

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.

MalaCards: Bulimia Nervosa, also known as bulimia nervosa, susceptibility to, is related to anorexia nervosa and eating disorder. An important gene associated with Bulimia Nervosa is BULN (Bulimia nervosa, susceptibility to), and among its related pathways are phenylalanine utilization and Adipocytokine signaling pathway. The compounds estrogen and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:63 Bulimia nervosa is an eating disorder characterized by binge eating and purging, or consuming a large... more...

Aliases & Classifications for Bulimia Nervosa

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8Disease Ontology, 9diseasecard, 46OMIM, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bulimia nervosa 8 46 44
bulimia nervosa, susceptibility to 9
binge eating disorder 60
hyperorexia nervosa 8


External Ids:

Disease Ontology8 DOID:12129
MeSH34 D002032
NCIt39 C34440
ICD1025 F50.2

Related Diseases for Bulimia Nervosa

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bulimia Nervosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa31.8HTR2A, BDNF
2eating disorder31.6SLC6A4, LEPR, LEP, RETN, MC4R, GHRL
3personality disorder31.0SLC6A4, MAOA, DRD4, HTR1B
4obesity30.9LEPR, LEP, RETN, MC4R, MAOA, GHRL
5borderline personality disorder30.9SLC6A4, MAOA, HTR1B
6morbid obesity30.7LEPR, LEP, RETN, MC4R, GHRL, LSL
7anxiety disorder30.6SLC6A4, MAOA, NPY, HTR2A, HTR3A, CCK
8seasonal affective disorder30.5SLC6A4, DRD4, HTR2A
9obsessive-compulsive disorder30.5SLC6A4, MAOA, DRD4, HTR2A, HTR3A, HTR1B
10pathological gambling30.4DRD4
11substance dependence30.4SLC6A4, DRD4, COMT
12attention deficit hyperactivity disorder30.4SLC6A4, MAOA, DRD4, HTR2A, HTR1B, BDNF
13mood disorder30.4SLC6A4, MAOA, DRD4, NPY, HTR2A, HTR3A
14type 2 diabetes mellitus30.3LEPR, LEP, RETN, MC4R, GHRL, HTR2A
15diabetes mellitus30.3LEPR, LEP, RETN, MC4R, GHRL, PPY
16thyroiditis30.2SERPINA7
17pancreatitis30.2PPY, CCK
18irritable bowel syndrome30.2SLC6A4, HTR3A, CCK
19bipolar disorder30.2SLC6A4, BDNF
20antisocial personality disorder30.2SLC6A4, MAOA, HTR2A, HTR1B
21celiac disease30.2GHRL, CCK, PYY
22cerebritis10.4
23alexithymia10.4
24physical disorder10.4
25avoidant personality disorder10.3
26gastric dilatation10.3
27rectal prolapse10.3
28esophagitis10.3
29bulimia nervosa, age of onset of weight loss in10.3
30adjustment disorder10.2
31double outlet right ventricle10.2
32intestinal disease10.2
33sleep disorder10.2
34crohn's disease10.1
35achalasia10.1
36hyperphosphatemia10.1
37obsessive-compulsive personality disorder10.1
38pain disorder10.1
39premenstrual tension10.1
40gastroesophageal reflux disease10.1
41tonsillitis10.1
42hypokalemia10.1
43kleptomania10.1
44graves' disease10.1
45compartment syndrome10.1
46esophageal cancer10.1
47esophageal disease10.1
48parotid disease10.1
49sexual disorder10.1
50neuroblastoma10.0BDNF

Graphical network of the top 20 diseases related to Bulimia Nervosa:



Diseases related to bulimia nervosa

Clinical Features for Bulimia Nervosa

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Drugs & Therapeutics for Bulimia Nervosa

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bulimia Nervosa

Drug clinical trials:

Search ClinicalTrials for Bulimia Nervosa

Search NIH Clinical Center for Bulimia Nervosa

Search CenterWatch for Bulimia Nervosa

Genetic Tests for Bulimia Nervosa

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Anatomical Context for Bulimia Nervosa

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32MalaCards
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MalaCards organs/tissues related to Bulimia Nervosa:

32
Brain, Testes, Cortex, Prefrontal cortex, Tonsil, Adrenal gland, Pituitary, T cells, Thyroid, Heart, Eye, Cingulate cortex

Animal Models for Bulimia Nervosa or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bulimia Nervosa:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2PYY, MC4R, RETN
2MP:00053799.8CCK, HTR1B, HTR3A, HTR2A, GHRL, LEP
3MP:00053789.7PYY, HTR1B, HTR3A, NPY, PPY, MC4R
4MP:00036319.6COMT, BDNF, PYY, CCK, HTR3A, NPY
5MP:00053909.6PYY, HTR1B, HTR2A, NPY, PPY, MC4R
6MP:00053769.5NPY, HTR3A, CCK, PYY, BDNF, COMT
7MP:00053869.5SLC6A4, COMT, BDNF, PYY, HTR1B, HTR3A

Publications for Bulimia Nervosa

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50PubMed
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Articles related to Bulimia Nervosa:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
A randomized controlled trial of psychoanalytic psychotherapy or cognitive-behavioral therapy for bulimia nervosa. (24275909)
2014
2
The efficacy of a brief group CBT program in treating patients diagnosed with bulimia nervosa: a brief report. (23568413)
2013
3
Behavioral Responses to Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa and Healthy Subjects. (24209774)
2013
4
A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder. (23790978)
2013
5
A cost effectiveness analysis of stepped care treatment for bulimia nervosa. (23354913)
2013
6
A classical case of bulimia nervosa from India. (24249937)
2013
7
Cognitive behaviour therapy response and dropout rate across purging and nonpurging bulimia nervosa and binge eating disorder: DSM-5 implications. (24200085)
2013
8
Zonisamide in the treatment of bulimia nervosa: an open-label, pilot, prospective study. (23893331)
2013
9
Unanticipated Rapid Remission of Refractory Bulimia Nervosa, during High-Dose Repetitive Transcranial Magnetic Stimulation of the Dorsomedial Prefrontal Cortex: A Case Report. (22529822)
2012
10
Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa. (22797368)
2012
11
Report weighs options for bulimia nervosa treatment. (21364132)
2011
12
Neurobiological and psychopathological variables related to emotional instability: a study of their capability to discriminate patients with bulimia nervosa from healthy controls. (21494052)
2011
13
Body schema and self-representation in patients with bulimia nervosa. (20186715)
2011
14
Cerebral venous sinus thrombosis associated with bulimia nervosa. (22707544)
2011
15
Stepped care and cognitive-behavioural therapy for bulimia nervosa: randomised trial. (21415046)
2011
16
Mobile therapy: Use of text-messaging in the treatment of bulimia nervosa. (19718672)
2010
17
Quantitative evidence for distinct cognitive impairment in anorexia nervosa and bulimia nervosa. (19619407)
2010
18
The effects of exercise in obese women with bulimia nervosa. (22375209)
2010
19
Evaluation of a functional treatment for binge eating associated with bulimia nervosa. (20571313)
2010
20
Cognitive-behavioural therapy for individuals with bulimia nervosa and a co-occurring substance use disorder. (19130465)
2009
21
Modified sham feeding of sweet solutions in women with and without bulimia nervosa. (18773914)
2009
22
Negative reinforcement eating expectancies, emotion dysregulation, and symptoms of bulimia nervosa. (19172595)
2009
23
Changes of body composition in bulimia nervosa: increased visceral fat and adrenal gland size. (19124623)
2009
24
Repetitive transcranial magnetic stimulation in bulimia nervosa: preliminary results of a single-centre, randomised, double-blind, sham-controlled trial in female outpatients. (18087209)
2008
25
Effect of eating rate on binge size in Bulimia Nervosa. (17996257)
2008
26
Early response to treatment in adolescent bulimia nervosa. (18570193)
2008
27
Adverse relationship processes: the attempts of women with bulimia nervosa symptoms to fit the perceived ideal of intimate partners. (18074329)
2008
28
Emotion recognition, emotional awareness and cognitive bias in individuals with bulimia nervosa. (18473338)
2008
29
Contribution of the serotoninergic system to anxious and depressive traits that may be partially responsible for the phenotypical variability of bulimia nervosa. (17055531)
2008
30
Tobacco use and comorbidity in bulimia nervosa. (18570194)
2008
31
Therapeutic drug monitoring of plasma fluvoxamine levels for treating bulimia nervosa. (17610677)
2007
32
Subtyping adolescents with bulimia nervosa. (17949682)
2007
33
Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa. (18250619)
2007
34
Body images of patients with anorexia nervosa, bulimia nervosa and female control subjects: a comparison with male ideals of female attractiveness. (18089251)
2007
35
Neuropsychological study of underweight and "weight-recovered" anorexia nervosa compared with bulimia nervosa and normal controls. (17607697)
2007
36
Management of bulimia nervosa. (19803857)
2007
37
Comorbidity and high-risk behaviors in treatment-seeking adolescents with bulimia nervosa. (17683094)
2007
38
No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa. (16472909)
2006
39
DSM-IV threshold versus subthreshold bulimia nervosa. (16715488)
2006
40
Diagnosing bulimia nervosa with parotid swelling. Case report. (17203854)
2006
41
Changes in internal states across the binge-vomit cycle in bulimia nervosa. (16772863)
2006
42
The use of parotid gland activity analysis in patients with gastro-esophageal reflux disease (GERD) and bulimia nervosa. (17357311)
2006
43
Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. (15999344)
2005
44
Temperament and character inventory and pharmacotherapeutic outcome in bulimia nervosa. (16682854)
2005
45
Changes in body image during cognitive-behavioral treatment in women with bulimia nervosa. (18089147)
2004
46
Binge and purge processes in bulimia nervosa: a qualitative investigation. (16864514)
2003
47
A qualitative investigation of the relapse experiences of women with bulimia nervosa. (16864511)
2003
48
Identification of patients with eating disorders. The signs and symptoms of anorexia nervosa and bulimia nervosa. (17644865)
2002
49
Hypokalemia leading to torsades de pointes. Munchausen's disorder or bulimia nervosa? (9328782)
1997
50
Ovarian morphology and insulin sensitivity in women with bulimia nervosa. (7586620)
1995

Genetic Variations for Bulimia Nervosa

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Expression for genes affiliated with Bulimia Nervosa

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bulimia Nervosa

Search GEO for disease gene expression data for Bulimia Nervosa.

Pathways for genes affiliated with Bulimia Nervosa

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Sources:
37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Bulimia Nervosa

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show top 50)    (show all 282)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7SLC6A4, SERPINA7
2gnrh4410.6LEPR, GHRL, PYY, BDNF
3estradiol44 11 2412.5SERPINA7, COMT, LEPR, BDNF
4citalopram49 44 11 2413.5MAOA, SLC6A4, HTR2A, HTR3A, BDNF
5sibutramine44 1111.5NPY, SLC6A4, LEP, PYY, LSL
6methysergide44 28 1112.5MAOA, HTR2A, HTR3A, HTR1B, CCK
7intralipid4410.5PYY, LSL, CCK, GHRL, LEP
8oxyntomodulin44 5911.5LEP, GHRL, NPY, CCK, PYY
9orlistat44 59 1112.4LSL, NPY, CCK, LEP, PYY, GHRL
10pramipexole44 49 28 1113.4HTR1B, BDNF, COMT, DRD4, HTR2A
11mhpg4410.4COMT, DRD4, MAOA, SLC6A4, NPY, BDNF
12fluvoxamine44 49 1112.4HTR2A, HTR3A, BDNF, SLC6A4, MAOA
13venlafaxine49 44 11 2413.4SLC6A4, BDNF, HTR1B, HTR3A, HTR2A
14ketanserin28 4411.4BDNF, HTR1B, HTR3A, HTR2A, SLC6A4
15fenfluramine28 44 1112.4CCK, HTR1B, HTR2A, NPY, LEP, SLC6A4
16fluoxetine49 44 28 1113.4HTR1B, HTR3A, HTR2A, MAOA, SLC6A4, BDNF
17maoa4410.4BDNF, HTR1B, HTR2A, DRD4, MAOA, SLC6A4
18methamphetamine44 49 1112.4SLC6A4, COMT, BDNF, NPY, DRD4, MAOA
19mcpp4410.3SLC6A4, HTR3A, HTR1B, HTR2A
20amine4410.3MAOA, MC4R, SLC6A4, HTR3A, HTR1B, PYY
21amphetamine44 1111.3NPY, PYY, CCK, DRD4, GHRL, MAOA
22yohimbine44 28 2 1113.3HTR3A, NPY, HTR2A, HTR1B, PYY
23quetiapine44 49 28 11 2414.3HTR1B, LSL, BDNF, LEP, GHRL, DRD4
24c-peptide4410.3PYY, LSL, GHRL, LEP, RETN, CCK
25pindolol44 28 1112.3HTR3A, HTR2A, SLC6A4, HTR1B
26tegaserod44 28 1112.2SLC6A4, HTR2A, HTR3A, CCK
27haloperidol44 28 2 49 1114.2HTR2A, NPY, DRD4, MC4R, SLC6A4, HTR3A
28pramlintide44 1111.2GHRL, CCK, LEP, PYY
29corticosterone44 59 2412.2SERPINA7, SLC6A4, LEPR, LEP, MC4R, GHRL
30amitriptyline44 49 28 1113.2HTR2A, HTR3A, MAOA, SLC6A4, SERPINA7
31acth4410.2MC4R, LEP, LEPR, SERPINA7, GHRL, BDNF
32epinephrine44 11 2412.2COMT, BDNF, LSL, LEP, DRD4, GHRL
33glucose4410.2SERPINA7, LEPR, PYY, CCK, LSL, NPY
34paroxetine44 49 28 1113.2GHRL, LEP, SLC6A4, MAOA, DRD4, COMT
35gaba4410.2PYY, SLC6A4, CCK, HTR3A, DRD4, GHRL
36clozapine44 28 49 1113.2HTR1B, LSL, BDNF, COMT, HTR3A, HTR2A
37thyroxine44 2411.2SERPINA7, LEPR, LEP, RETN, GHRL, NPY
38olanzapine49 44 28 11 2414.2GHRL, DRD4, HTR2A, HTR3A, HTR1B, LEPR
39methylphenidate44 49 1112.1COMT, DRD4, SLC6A4, MAOA
40norepinephrine44 11 2412.1BDNF, HTR2A, MAOA, DRD4, SLC6A4, PYY
41risperidone28 44 49 59 11 2415.1SLC6A4, LEP, GHRL, DRD4, LSL, BDNF
425-hydroxytryptamine4410.1COMT, PYY, CCK, HTR1B, HTR3A, HTR2A
43alpha msh4410.1MC4R, CCK, LEP, NPY
44cocaine44 1111.0COMT, BDNF, PYY, CCK, HTR1B, DRD4
45cholesterol44 28 11 2413.0RETN, SERPINA7, LEPR, LEP, MC4R, GHRL
46glutamate4410.0LEP, COMT, BDNF, CCK, MAOA, NPY
47arginine449.9NPY, MC4R, GHRL, LEP, LEPR, SLC6A4
48testosterone44 59 11 2412.9SERPINA7, MAOA, RETN, LEP, LEPR, SLC6A4
49dopamine44 28 11 2412.8NPY, DRD4, GHRL, MC4R, LEPR, SLC6A4
506-hydroxydopamine449.8MAOA, DRD4, NPY, BDNF, COMT

GO Terms for genes affiliated with Bulimia Nervosa

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16Gene Ontology
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Cellular components related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.2GHRL, HTR2A, HTR3A, CCK
2extracellular spaceGO:0056159.7PYY, CCK, NPY, GHRL, RETN, LEP
3extracellular regionGO:0055769.6SERPINA7, BDNF, PYY, CCK, NPY, PPY

Biological processes related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.6GHRL, NPY
2adult feeding behaviorGO:00834310.6LEP, GHRL, NPY
3dopamine catabolic processGO:04242010.6MAOA, COMT
4eating behaviorGO:04275510.6LEP, CCK, PYY
5negative regulation of appetiteGO:03209910.6LEP, CCK
6behavioral fear responseGO:00166210.6BDNF, CCK, DRD4
7feeding behaviorGO:00763110.5MC4R, NPY, PYY, BDNF
8neurotransmitter catabolic processGO:04213510.5MAOA, COMT
9negative regulation of synaptic transmission, glutamatergicGO:05196710.5HTR1B, HTR2A
10negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
11response to insulin stimulusGO:03286810.5MC4R, RETN, LEP
12regulation of dopamine secretionGO:01405910.5HTR1B, HTR2A
13digestionGO:00758610.5PYY, HTR3A, NPY, PPY
14serotonin receptor signaling pathwayGO:00721010.4HTR3A, HTR2A
15regulation of behaviorGO:05079510.4HTR1B, HTR2A
16synaptic transmissionGO:00726810.3COMT, HTR1B, HTR3A, HTR2A, NPY, MAOA
17neurotransmitter biosynthetic processGO:04213610.3MAOA, COMT
18response to vitamin AGO:03318910.2BDNF, SERPINA7
19response to drugGO:04249310.1SERPINA7, SLC6A4, HTR2A, COMT
20energy reserve metabolic processGO:0061129.9LEPR, LEP, MC4R

Molecular functions related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.3HTR2A, HTR3A, HTR1B
2neuropeptide hormone activityGO:00518410.3PYY, CCK, NPY
3drug bindingGO:00814410.2DRD4, HTR2A, HTR1B
4hormone activityGO:00517910.2LEP, RETN, PPY, CCK, PYY
5serotonin receptor activityGO:00499310.2HTR2A, HTR3A, HTR1B
6G-protein coupled receptor bindingGO:0016649.9NPY, PPY, GHRL

Products for genes affiliated with Bulimia Nervosa

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Sources for Bulimia Nervosa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet