Bulimia Nervosa malady

Disease Ontology: An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.⁶

MalaCards: Bulimia Nervosa, also known as binge eating disorder, is related to anorexia nervosa and attention deficit hyperactivity disorder. An important gene associated with Bulimia Nervosa is BULN (Bulimia nervosa, susceptibility to), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Amine ligand-binding receptors. The drugs fluoxetine and maprotiline hydrochloride and the compounds glucose and carbohydrates have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Wikipedia: Bulimia nervosa is an eating disorder characterized by binge eating and purging, or consuming a large...⁴⁴ more...

Aliases & Descriptions:

bulimia nervosa 6 33 32 binge eating disorder 43

hyperorexia nervosa 6 bulimia 43

Diseases related to bulimia nervosa by text searches and GeneDecks gene sharing:

(show top 50)    (show all 507)

id	Related Disease	Score	Top Affiliating Genes
1	anorexia nervosa	36.9	BDNF, HTR2A
2	attention deficit hyperactivity disorder	30.7	BDNF, MAOA, HTR1B, HTR2A, HTR2C, DRD4
3	eating disorder	27.6	RETN, CNR1, CNR2, GCG, CLOCK, BDNF
4	obsessive-compulsive disorder	27.3	BDNF, MAOA, CCK, HTR1B, HTR2A, HTR2C
5	adhd	26.5	CNR1, BDNF, INS, MAOA, HTR1B, HTR2A
6	hypoglycemia	22.1	GCG, BDNF, LEP, INS, CCK, HTR2A
7	obesity	21.4	RETN, CNR1, CNR2, GCG, NAMPT, CLOCK
8	blindness	20.3	CNR1, GCG, SERPINA7, LEP, CD40LG, INS
9	thyroiditis	19.5	RETN, CNR2, GCG, SERPINA7, NAMPT, LEP
10	pancreatitis	19.0	RETN, CNR1, CNR2, GCG, NAMPT, BDNF
11	schizophrenia	17.1	CNR1, CNR2, CLOCK, BDNF, LEP, LEPR
12	conduct disorder	13.8	MAOA, HTR1B, SLC6A4
13	anxiety-related personality traits	13.8	BDNF, COMT, SLC6A4
14	gallbladder disease	13.7	CCK, CCKAR, PYY
15	panic disorder	13.7	CCK, COMT
16	leptin receptor deficiency	13.7	LEP, LEPR
17	duodenogastric reflux	13.7	CCK, PYY, NTS
18	novelty seeking personality	13.7	MAOA, DRD4, COMT
19	endogenous depression	13.7	BDNF, CRH, SLC6A4
20	normal pressure hydrocephalus	13.7	BDNF, PYY, NPY, GAL
21	glucose intolerance	13.6	GCG, CCK, GHRL, PYY
22	cannabis dependence	13.6	CNR1, FAAH, COMT
23	major affective disorder	13.6	HTR2A, HTR3A, TPH1
24	amnestic disorder	13.6	HTR3A, PDYN, PREP
25	cognitive disease	13.6	BDNF, HTR3A, COMT, GAL
26	antisocial personality disorder	13.6	MAOA, HTR1B, HTR2A, DRD4, SLC6A4
27	memory impairment	13.6	CNR1, BDNF, HTR2A, PDYN
28	pathological gambling	13.5	MAOA, DRD4, SLC6A4
29	manic-depressive illness	13.5	MAOA, TPH1, DRD4, SLC6A4
30	fragile x syndrome	13.5	BDNF, MAOA, ST14, SLC6A4
31	migraine with aura	13.5	HTR1B, HTR2A, HTR2C, SLC6A4
32	personality disorder	13.5	MAOA, HTR1B, TPH1, DRD4, SLC6A4
33	pulmonary hypertension	13.5	HTR1B, HTR3A, TPH1, SLC6A4
34	drug addiction	13.5	BDNF, NTS, CRH, PDYN
35	myoma	13.5	LEP, LEPR, LSL, OXT
36	social phobia	13.5	MAOA, HTR3A, COMT, OXT, SLC6A4
37	gastroesophageal reflux disease	13.5	GCG, CCK, CCKAR, PYY, NTS
38	central nervous system disease	13.4	CNR1, BDNF, HTR2A, DPP4, SLC6A4
39	neurotic disorder	13.4	BDNF, MAOA, HTR2A, HTR3A, DRD4, COMT
40	huntington's disease	13.4	CNR1, BDNF, FAAH, NTS, NPY
41	vipoma	13.4	GH1, NTS, PPY
42	leptin deficiency	13.4	LEP, LEPR, CCK, GH1, LSL, NPY
43	glanders	13.4	RETN, LEP, LEPR, IL2RA
44	aggressive digital papillary adenocarcinoma	13.3	MAOA, HTR1B, HTR3A, TPH1, DRD4, COMT
45	autistic disorder	13.3	BDNF, HTR2A, DRD4, OXT, SLC6A4
46	generalized anxiety disorder	13.3	MAOA, HTR2A, HTR2C, HTR3A, TPH1, NPY
47	uterine fibroid	13.3	LEPR, COMT, SHBG, LSL, OXT
48	relapsing-remitting multiple sclerosis	13.3	BDNF, IL2RA, LSL
49	delayed puberty	13.3	LEP, LSL, PRL, NPY
50	nutritional deficiency disease	13.3	LEP, GHRL, TF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 fenfluramine, fenfluramine hydrochloride, fluoxetine, fluoxetine hydrochloride, maprotiline, maprotiline hydrochloride

MalaCards organs/tissues related to bulimia nervosa:

²²

MGI Mouse Phenotypes related to bulimia nervosa:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	PREP, ST14
2	endocrine/exocrine gland phenotype	MP:0005379	9.7	CD40LG, CCKAR, HTR1B, HTR2A, DPP4, GAL
3	renal/urinary system phenotype	MP:0005367	9.2	PREP, OXT, TNFRSF1B, HTR3A, CCKAR, INS
4	liver/biliary system phenotype	MP:0005370	8.6	PRL, GH1, CCKAR, MC4R, INS, CLOCK
5	skeleton phenotype	MP:0005390	8.6	TNFRSF1B, PYY, PPY, NR3C1, PDYN, GHSR
6	no phenotypic analysis	MP:0003012	8.6	POMC, NTS, GHSR, GHRL, INS, LEPR
7	mortality/aging	MP:0010768	7.5	HTR2C, HTR3A, NR3C1, TF, OXT, SLC6A4
8	reproductive system phenotype	MP:0005389	7.4	GAL, ADIPOQ, PRL, OXT, COMT, TNF
9	digestive/alimentary phenotype	MP:0005381	6.8	GHSR, TNF, TNFRSF1B, NR3C1, PDYN, ST14
10	integument phenotype	MP:0010771	6.7	CRH, PDYN, ST14, OXT, PRL, POMC
11	cardiovascular system phenotype	MP:0005385	6.4	NR3C1, COMT, OXT, POMC, SLC6A4, ADIPOQ
12	nervous system phenotype	MP:0003631	6.0	NTS, NR3C1, CRH, COMT, PDYN, PREP
13	adipose tissue phenotype	MP:0005375	5.7	HTR2C, GH1, GHRL, GHSR, TPH1, TNF
14	growth/size phenotype	MP:0005378	5.7	MC4R, CCKAR, HTR1B, HTR2C, HTR3A, GH1
15	cellular phenotype	MP:0005384	5.7	TNFRSF1B, NR3C1, CRH, PDYN, ST14, POMC
16	immune system phenotype	MP:0005387	5.1	TNFRSF1B, NR3C1, CRH, COMT, ST14, PREP
17	behavior/neurological phenotype	MP:0005386	3.7	COMT, PDYN, ST14, OXT, PREP, PRL
18	homeostasis/metabolism phenotype	MP:0005376	1.8	RETN, GHRL, GHSR, TPH1, TNF, TNFRSF1B

Articles related to bulimia nervosa:

(show top 50)    (show all 84)

id	Title	Authors	Year	Affiliating Genes
1	COMT Val158Met variant and functional haplotypes asso ciated with childhood ADHD history in women with bulimia nervosa. (21300128)	Yilmaz Z.... Kennedy J.L.	2011	COMT
2	Changes of plasma obestatin, ghrelin and NPY in anore xia and bulimia nervosa patients before and after a high-carbohydrate breakfast . (20945961)	SedlA!A8kovA! D.... NedvA-dkovA! J.	2011	NPY, GHRL
3	Women with bulimia nervosa exhibit attenuated secreti on of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal. (21813805)	NaessAcn S.... Hirschberg A.L.	2011	GCG, INS, PPY
4	Contributions of the glucocorticoid receptor polymorp hism (Bcl1) and childhood abuse to risk of bulimia nervosa. (21093928)	Steiger H.... Kin F.N.	2011	NR3C1
5	A Season-of-Birth/DRD4 Interaction Predicts Maximal B ody Mass Index in Women with Bulimia Nervosa. (20336060)	Levitan R.D.... Kennedy J.L.	2010	DRD4
6	Glucagon-like peptide-1 secretion in bulimia nervosa. (19631991)	Brambilla F.... Maj M.	2009	GCG
7	Serum visfatin levels in patients with anorexia nervo sa and bulimia nervosa. (19093738)	DostA!lovA! I.... HaluzA-k M.	2009	LEP, NAMPT
8	Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa. (18175732)	Dynesen A.W.... Nauntofte B.	2008	LEP, GHRL
9	Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa. (18728162)	Monteleone P.... Maj M.	2008	GHRL
10	The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: a preliminary study. (17516548)	Tortorella A.... Maj M.	2007	CLOCK
11	Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa. (17768271)	Keel P.K.... Jimerson D.C.	2007	CCK
12	Association between A218C polymorphism of the tryptophan-hydroxylase-1 gene, harm avoidance and binge eating behavior in bulimia nervosa. (17548152)	Monteleone P.... Maj M.	2007	TPH1
13	Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa. (18250619)	Torsello A.... Locatelli V.	2007	LEP, GHRL
14	Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population. (16362631)	Miyasaka K.... Funakoshi A.	2006	CCKAR, GHSR
15	Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. (16921495)	Ando T.... Ichimaru Y.	2006	GHRL
16	Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa. (16538179)	Cellini E.... Sorbi S.	2006	GHRL
17	The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder. (16901635)	Monteleone P.... Maj M.	2006	BDNF
18	The serotonin-1Dbeta receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa. (15944142)	Levitan R.D.... Kennedy J.L.	2006	HTR1B
19	Relationship between plasma concentrations of cytokin es, ratio of CD4 and CD8, lymphocyte proliferative responses, and depressive an d anxiety state in bulimia nervosa. (16380316)	Nagata T.... Kiriike N.	2006	IL2RA, TNFRSF1B
20	Serotonin transporter polymorphism and potential response to SSRIs in bulimia nervosa. (15940301)	Monteleone P.... Maj M.	2005	SLC6A4
21	Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. (15841111)	Monteleone P.... Di Marzo V.	2005	LEP, CNR1, CNR2
22	Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. (15598689)	Housova J.... Haluzik M.	2005	ADIPOQ, RETN
23	Circulating ghrelin is decreased in non-obese and obe se women with binge eating disorder as well as in obese non-binge eating women, but not in patients with bulimia nervosa. (15511598)	Monteleone P.... Maj M.	2005	GHRL
24	Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. (15999344)	Bruce K.R.... Young S.N.	2005	HTR2A
25	Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa. (15808922)	Fassino S.... Gianotti L.	2005	POMC, PRL, INS
26	Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge-eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables. (15997610)	Monteleone P.... Maj M.	2005	BDNF
27	Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa. (15820714)	Monteleone P.... Maj M.	2005	GHRL, PYY
28	Adiponectin in anorexia nervosa and bulimia nervosa. (15070952)	Tagami T.... Kuzuya H.	2004	LEP, ADIPOQ
29	Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa. (15245785)	Ricca V.... Sorbi S.	2004	HTR2A
30	Analysis of the -1438 G/A polymorphism of the 5-HT2A serotonin receptor gene in bulimia nervosa patients with or without a history of anorexia nervosa. (15167698)	Fuentes J.A.... Garcia-Camba E.	2004	HTR2A
31	Opposite changes in circulating adiponectin in women with bulimia nervosa or binge eating disorder. (14602778)	Monteleone P.... Maj M.	2003	ADIPOQ
32	Leptin in anorexia nervosa and bulimia nervosa: importance of assay technique and method of interpretation. (11919545)	Frederich R.... Pomeroy C.	2002	LEP, LSL
33	Leptin secretion is related to chronicity and severity of the illness in bulimia nervosa. (12461192)	Monteleone P.... Maj M.	2002	LEP
34	Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa. (11690602)	Levitan R.D.... Kennedy J.L.	2001	HTR1B
35	Central dopaminergic function in anorexia and bulimia nervosa: a psychoneuroendocrine approach. (11259859)	Brambilla F.... Limonta D.	2001	GH1
36	Lower serum activity of prolyl endopeptidase in anorexia and bulimia nervosa. (11070331)	Maes M.... Scharpe S.	2001	KNG1, PREP, NTS
37	Efficacy and tolerability of moclobemide in bulimia nervosa: a placebo-controlled trial. (11195257)	Carruba M.O.... Nisoli E.	2001	MAOA
38	Endocrine and reproductive disturbances in anorexia nervosa and bulimia nervosa (11268607)	Hasegawa K.	2001	LEP
39	Plasma concentrations of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors in patients with bulimia nervosa. (10971457)	Nakai Y.... Kurimoto F.	2000	TNF
40	Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes. (10808037)	Monteleone P.... Maj M.	2000	LEP
41	Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. (10889521)	Di Bella D.D.... Bellodi L.	2000	SLC6A4
42	Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder. (10412190)	Burnet P.W.... Harrison P.J.	1999	HTR2C
43	Visceral protein and hematological status of women with bulimia nervosa and depressed controls. (10222489)	Gendall K.A.... Joyce P.R.	1999	TF
44	Bulimia nervosa and autoimmunity. (10512157)	Corcos M.... Jeammet P.	1999	CD40LG
45	Serum leptin and body weight in females with anorexia and bulimia nervosa. (9660088)	KAPpp W.... Hebebrand J.	1998	LEP, LSL
46	Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa. (8988922)	Devlin M.J.... Petkova E.	1997	CCK
47	Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease. (9156037)	Ferron F.... Casanueva F.F.	1997	LEP, LSL
48	Ovarian morphology and insulin sensitivity in women with bulimia nervosa. (7586620)	Raphael F.J.... Lacey J.H.	1995	INS, SHBG
49	Correlations of plasma and urinary phenylacetic acid and phenylethylamine concentrations with eating behavior and mood rating scores in brofaromine-treated women with bulimia nervosa. (7918350)	Davis B.A.... Boulton A.A.	1994	MAOA
50	Altered cerebrospinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa. (2350207)	Kaye W.H.... George D.T.	1990	NPY, PYY

Genes related to bulimia nervosa according to GeneCards:

(show top 50)    (show all 54)

id	Symbol	Description	Score	GeneCards Section Context
1	BULN	Bulimia nervosa, susceptibility to	11.1	Publications, Aliases & Descriptions
2	BDNF	brain-derived neurotrophic factor	11.0	UniProt Related, Publications
3	PYY	peptide YY	11.0	Publications
4	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
5	LSL	Leptin, serum levels of	11.0	Publications
6	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
7	NPY	neuropeptide Y	11.0	Publications
8	MAOA	monoamine oxidase A	11.0	Publications
9	MC4R	melanocortin 4 receptor	11.0	Publications
10	CCK	cholecystokinin	11.0	Publications
11	LEP	leptin	11.0	Publications
12	RETN	resistin	11.0	Publications
13	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
14	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
15	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
16	COMT	catechol-O-methyltransferase	11.0	Publications
17	LEPR	leptin receptor	11.0
18	PPY	pancreatic polypeptide	11.0	Publications
19	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
20	TPH1	tryptophan hydroxylase 1	11.0	Publications
21	ST14	suppression of tumorigenicity 14 (colon carcinoma)	11.0	Publications
22	NTS	neurotensin	11.0	Publications
23	PDYN	prodynorphin	11.0	Publications
24	PREP	prolyl endopeptidase	11.0	Publications
25	NAMPT	nicotinamide phosphoribosyltransferase	11.0	Publications
26	GHSR	growth hormone secretagogue receptor	11.0	Publications
27	FAAH	fatty acid amide hydrolase	11.0	Publications
28	CNR2	cannabinoid receptor 2 (macrophage)	11.0	Publications
29	CCKAR	cholecystokinin A receptor	11.0	Publications
30	CEP70	centrosomal protein 70kDa	11.0
31	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
32	DRD4	dopamine receptor D4	11.0	Publications
33	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
34	CLOCK	clock homolog (mouse)	11.0	Publications
35	GAL	galanin prepropeptide	11.0	Publications
36	MED16	mediator complex subunit 16	11.0
37	GCG	glucagon	11.0	Publications
38	CRH	corticotropin releasing hormone	11.0	Publications
39	SPATA17	spermatogenesis associated 17	11.0
40	SHBG	sex hormone-binding globulin	11.0	Publications
41	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Publications
42	DPP4	dipeptidyl-peptidase 4	11.0	Publications
43	OXT	oxytocin, prepropeptide	11.0	Publications
44	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
45	TF	transferrin	11.0	Publications
46	CD40LG	CD40 ligand	11.0	Publications
47	KNG1	kininogen 1	11.0	Publications
48	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
49	GH1	growth hormone 1	11.0	Publications
50	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications

Pathways related to bulimia nervosa according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.4	SLC6A4, TPH1, HTR2A, MAOA
2	Amine ligand-binding receptors38	10.0	HTR1B, HTR2A, HTR2C, DRD4
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	IL2RA
4	G alpha (q) signalling events38	9.8	OXT, NTS, GHSR, GHRL, CCKAR, CCK
5	Class A/1 (Rhodopsin-like receptors)38	9.7	GAL, NPY, PDYN, PPY, PYY, MC4R
6	Selected targets of CREB110	9.3	GAL, PDYN, CRH, CCK, INS, GCG
7	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	TNFRSF1B, TNF, IL2RA
8	Selected targets of GCR-alpha10	9.2	LEP, INS, GHSR, NR3C1
9	Apoptotic Pathways in Synovial Fibroblasts36	8.7	BDNF, IL2RA, GH1, TNF, TNFRSF1B
10	Adipocytokines & Insulin Signaling37	8.6	ADIPOQ, TNF, INS, LEP, NAMPT, RETN
11	Adipocytokine signaling pathway20	8.6	ADIPOQ, NPY, POMC, TNFRSF1B, TNF, LEPR
12	Neuroactive ligand-receptor interaction20	7.8	CNR1, PRL, NR3C1, DRD4, GHSR, GH1
13	Cytokine-cytokine receptor interaction20	7.8	PRL, TNFRSF1B, TNF, GH1, IL2RA, CD40LG

Compounds related to bulimia nervosa according to GeneDecks:

(show top 50)    (show all 390)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.2	GCG, GHSR, NTS, PDYN
2	carbohydrates32	10.0	CCKAR, CCK, PYY, DPP4, TF, NPY
3	carbachol32 9 9	11.7	KNG1, CRH, CCK, GCG
4	haloperidol32 34 9 9	12.6	HTR3A, HTR2A, CCKAR, MC4R, BDNF, DRD4
5	alpha msh32	9.5	CCK, MC4R, LEP, NTS, CRH, POMC
6	mhpg32	9.5	SLC6A4, NPY, PRL, COMT, CRH, DRD4
7	sibutramine32 9 9	11.5	INS, LEP, CNR1, PYY, ADIPOQ, SLC6A4
8	tetrodotoxin32	9.4	CNR1, GCG, BDNF, CCK, GAL, NPY
9	maoa32	9.3	SLC6A4, POMC, COMT, DRD4, TPH1, HTR2C
10	capsaicin32	9.3	GAL, KNG1, NPY, PDYN, CRH, NTS
11	paroxetine32 34 9 9	12.3	LEP, MAOA, SLC6A4, PRL, COMT, DRD4
12	risperidone32 34 9 18 9	13.2	BDNF, LEP, HTR2A, SLC6A4, PRL, LSL
13	c-peptide32	9.1	RETN, GCG, GAL, ADIPOQ, DPP4, LSL
14	orlistat32 42 9 9	12.1	GHRL, CCK, INS, LEP, GCG, CNR1
15	sulpiride32 9 9	10.8	NPY, PRL, PDYN, CRH, NTS, DRD4
16	atropine32 9 9	10.8	GCG, CCK, CCKAR, GAL, KNG1, NPY
17	topiramate32 42 9 18 9	12.8	ADIPOQ, NPY, POMC, CRH, HTR2C, LEP
18	bromocriptine32 9 9	10.6	GAL, POMC, PRL, GH1, HTR2C, HTR2A
19	apomorphine32 9 9	10.6	CNR1, PRL, OXT, COMT, NTS, DRD4
20	fluoxetine32 34 9 9	11.5	SLC6A4, PRL, OXT, SHBG, CRH, TPH1
21	hexarelin32	8.5	GAL, POMC, PRL, OXT, CRH, GHSR
22	nifedipine32 9 9	10.1	ADIPOQ, KNG1, NPY, OXT, TF, CRH
23	naloxone32 34 9 9	11.0	GAL, CNR1, LEP, POMC, PRL, OXT
24	levodopa32 9 9	9.9	GAL, PRL, TF, PDYN, COMT, NTS
25	clozapine32 34 9 9	10.9	IL2RA, LEP, HTR2A, SLC6A4, POMC, PRL
26	glutamate32	7.9	HTR2C, MAOA, INS, LEPR, LEP, GCG
27	dehydroepiandrosterone sulfate32	7.8	ADIPOQ, POMC, PRL, LSL, SHBG, CRH
28	testosterone32 9 18 9	10.7	GAL, SLC6A4, PRL, OXT, LSL, SERPINA7
29	epinephrine32 9 18 9	10.7	LSL, GCG, BDNF, SHBG, PDYN, COMT
30	corticosterone32 18	8.6	NTS, GHRL, GH1, MC4R, LEPR, BDNF
31	opiate32	7.2	GAL, CCK, MC4R, GH1, GHRL, NTS
32	5-hydroxytryptamine32	7.2	DRD4, TPH1, GHRL, HTR3A, HTR2C, HTR2A
33	dhea32	7.1	RETN, LEP, INS, GH1, GAL, ADIPOQ
34	nitric oxide32 9 18 9	10.0	GAL, KNG1, NPY, HTR1B, FAAH, MC4R
35	indomethacin32 9 9	9.0	KNG1, NPY, POMC, CRH, NTS, TNF
36	forskolin32 42 9 9	10.0	CCK, BDNF, GCG, CNR2, RETN, GH1
37	histamine32 18	7.9	NTS, PYY, TNF, GHRL, HTR3A, CCK
38	alanine32	6.6	ADIPOQ, SLC6A4, NPY, POMC, PREP, TF
39	creatinine32	6.6	CD40LG, LEP, BDNF, NAMPT, SERPINA7, GCG
40	acth32	6.5	GAL, NPY, POMC, PRL, OXT, LSL
41	acetylcholine32 9 18 9	9.3	GAL, ADIPOQ, KNG1, NPY, POMC, PDYN
42	thyroxine32 18	7.2	GH1, INS, CD40LG, LEPR, LEP, SERPINA7
43	hydrocortisone32 9 9	8.2	INS, GH1, GHRL, GHSR, ADIPOQ, POMC
44	dopamine32 9 18 9	9.1	CD40LG, LEPR, BDNF, CLOCK, GCG, IL2RA
45	cocaine32 9 9	7.8	GAL, ADIPOQ, SLC6A4, NPY, POMC, PRL
46	lipid32	5.6	GH1, CNR1, RETN, CNR2, GCG, SERPINA7
47	dexamethasone32 42 34 9 9	8.3	MAOA, IL2RA, INS, CD40LG, LEPR, LEP
48	estrogen32	4.1	GAL, ADIPOQ, SLC6A4, NPY, POMC, PRL
49	norepinephrine32 9 18 9	7.0	GHRL, CNR1, RETN, GCG, BDNF, LEP
50	serine32	3.9	GAL, ADIPOQ, KNG1, SLC6A4, POMC, PREP

Cellular components related to bulimia nervosa according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	terminal button	GO:043195	9.7	OXT, DRD4, CCKAR, CCK
2	membrane raft	GO:045121	8.7	SLC6A4, DPP4, TNFRSF1B, TNF, GHSR
3	secretory granule	GO:030141	8.5	GAL, POMC, OXT, TF, GHRL, INS
4	integral to plasma membrane	GO:005887	8.2	ST14, DRD4, TNF, HTR3A, HTR2A, HTR1B
5	plasma membrane	GO:005886	6.2	GHSR, TNF, TNFRSF1B, DRD4, COMT, PDYN
6	extracellular space	GO:005615	6.0	CRH, ST14, OXT, POMC, NPY, KNG1
7	extracellular region	GO:005576	4.9	GAL, CRH, PDYN, SHBG, DPP4, TF

Biological processes related to bulimia nervosa according to GeneDecks:

(show all 31)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of appetite	GO:032100	10.6	NPY, GHSR, GHRL
2	adult feeding behavior	GO:008343	10.5	LEP, GHRL, GHSR, NPY
3	negative regulation of appetite	GO:032099	10.5	CCK, LEP, GCG
4	growth hormone secretion	GO:030252	10.4	GAL, GHSR, GHRL
5	digestion	GO:007586	10.3	NPY, PPY, PYY, HTR3A, CCKAR
6	serotonin receptor signaling pathway	GO:007210	10.3	HTR2A, HTR2C, HTR3A
7	eating behavior	GO:042755	10.3	LEP, CCK, PYY, OXT
8	behavior	GO:007610	10.3	CNR1, CNR2, MAOA, NPY
9	positive regulation of cortisol secretion	GO:051464	10.3	CRH, GHRL
10	insulin secretion	GO:030073	10.3	GAL, CCKAR, MC4R, LEP
11	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	10.3	NPY, HTR1B, CNR2, CNR1
12	response to cocaine	GO:042220	10.2	OXT, HTR3A, HTR1B, CNR1
13	negative regulation of circadian sleep/wake cycle, REM sleep	GO:042322	10.2	CRH, GHRL
14	memory	GO:007613	10.1	SLC6A4, OXT, HTR2A, CNR1
15	positive regulation of fatty acid metabolic process	GO:045923	10.0	ADIPOQ, GHSR
16	positive regulation of synapse assembly	GO:051965	10.0	BDNF, GHRL, OXT
17	negative regulation of inflammatory response	GO:050728	10.0	ADIPOQ, TNFRSF1B, GHSR, GHRL, CNR2
18	negative regulation of blood pressure	GO:045776	9.9	CNR1, OXT, NPY, ADIPOQ
19	circadian rhythm	GO:007623	9.9	SLC6A4, NR3C1, LEP, CLOCK
20	positive regulation of multicellular organism growth	GO:040018	9.9	GH1, GHRL, GHSR
21	response to insulin stimulus	GO:032868	9.8	GAL, NR3C1, MC4R, LEP
22	positive regulation of blood pressure	GO:045777	9.8	CNR1, OXT, ADIPOQ
23	synaptic transmission	GO:007268	9.8	NPY, PDYN, COMT, CRH, HTR3A, HTR2C
24	energy reserve metabolic process	GO:006112	9.7	MC4R, INS, LEPR, LEP, GCG
25	feeding behavior	GO:007631	9.6	GCG, GAL, NPY, CRH, PYY, HTR2C
26	female pregnancy	GO:007565	9.5	PRL, OXT, COMT, CRH, LEP
27	response to drug	GO:042493	9.1	GAL, SLC6A4, COMT, TNF, HTR2C, HTR2A
28	regulation of insulin secretion	GO:050796	9.0	TNF, INS, LEP, GCG, CNR1
29	glucose metabolic process	GO:006006	8.8	ADIPOQ, TNF, GHRL, INS, LEP
30	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.8	ADIPOQ, GH1, CCK, INS
31	inflammatory response	GO:006954	8.5	GAL, KNG1, CRH, TNFRSF1B, TNF, CD40LG

Molecular functions related to bulimia nervosa according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO:071886	10.1	HTR2A, HTR2C
2	serotonin receptor activity	GO:004993	10.0	HTR3A, HTR2C, HTR2A, HTR1B
3	serotonin binding	GO:051378	10.0	HTR3A, HTR2C, HTR2A, HTR1B, MAOA
4	neuropeptide hormone activity	GO:005184	9.9	GAL, NPY, CRH, NTS, PYY, CCK
5	drug binding	GO:008144	9.6	DRD4, HTR2C, HTR2A, HTR1B, CNR1
6	G-protein coupled receptor binding	GO:001664	9.5	GHRL, PPY, POMC
7	receptor binding	GO:005102	8.4	ADIPOQ, KNG1, NPY, POMC, DPP4, CRH
8	hormone activity	GO:005179	7.4	RETN, ADIPOQ, POMC, PRL, CRH, PPY