MCID: BLM002
MIFTS: 58

Bulimia Nervosa malady

Neuronal category

Summaries for Bulimia Nervosa

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.

MalaCards: Bulimia Nervosa, also known as bulimia nervosa, susceptibility to, is related to anorexia nervosa and borderline personality disorder. An important gene associated with Bulimia Nervosa is BULN (Bulimia nervosa, susceptibility to), and among its related pathways are phenylalanine utilization and Adipocytokine signaling pathway. The compounds estrogen and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:64 Bulimia nervosa is an eating disorder characterized by binge eating and purging, or consuming a large... more...

Aliases & Classifications for Bulimia Nervosa

Sources:
8Disease Ontology, 47OMIM, 45Novoseek, 9diseasecard, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

bulimia nervosa 8 47 45
bulimia nervosa, susceptibility to 9
binge eating disorder 61
hyperorexia nervosa 8


External Ids:

Disease Ontology8 DOID:12129
MeSH35 D002032
NCIt40 C34440
ICD1025 F50.2

Related Diseases for Bulimia Nervosa

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bulimia Nervosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa31.8HTR2A, BDNF
2borderline personality disorder30.9SLC6A4, MAOA, HTR1B
3anxiety disorder30.7SLC6A4, MAOA, NPY, HTR2A, HTR3A, CCK
4seasonal affective disorder30.6SLC6A4, DRD4, HTR2A
5obsessive-compulsive disorder30.6SLC6A4, MAOA, DRD4, HTR2A, HTR3A, HTR1B
6morbid obesity30.5LEPR, LEP, RETN, MC4R, GHRL, LSL
7pathological gambling30.5DRD4
8substance dependence30.4SLC6A4, DRD4, COMT
9attention deficit hyperactivity disorder30.4SLC6A4, MAOA, DRD4, HTR2A, HTR1B, BDNF
10irritable bowel syndrome30.2SLC6A4, HTR3A, CCK
11bipolar disorder30.2SLC6A4, BDNF
12antisocial personality disorder30.2SLC6A4, MAOA, HTR2A, HTR1B
13celiac disease30.2GHRL, CCK, PYY
14n syndrome10.5
15alexithymia10.4
16avoidant personality disorder10.3
17gastric dilatation10.3
18rectal prolapse10.3
19anorexia nervosa 110.3
20bulimia nervosa, age of onset of weight loss in10.3
21double outlet right ventricle10.2
22sleep disorder10.2
23achalasia10.2
24hyperphosphatemia10.2
25obsessive-compulsive personality disorder10.2
26pain disorder10.2
27premenstrual tension10.2
28gastroesophageal reflux disease10.2
29tonsillitis10.2
30hypokalemia10.2
31kleptomania10.2
32graves' disease10.2
33cerebral atrophy10.2
34drug addiction10.2
35obesity, early-onset10.2
36venous thrombosis10.2
37blindness10.2
38neuroblastoma10.0BDNF
39premature ejaculation10.0SLC6A4
40heroin dependence10.0DRD4
41amenorrhea10.0LEP
42restless legs syndrome10.0HTR3A
43thyroiditis10.0SERPINA7
44ischemia10.0GHRL, BDNF
45cocaine dependence10.0SLC6A4
46leiomyoma10.0COMT
47asthma10.0GHRL, HTR2A
48substance abuse10.0SLC6A4, DRD4
49chronic fatigue syndrome10.0SLC6A4, MAOA
50paranoid schizophrenia10.0COMT

Graphical network of the top 20 diseases related to Bulimia Nervosa:



Diseases related to bulimia nervosa

Clinical Features for Bulimia Nervosa

Drugs & Therapeutics for Bulimia Nervosa

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bulimia Nervosa

Drug clinical trials:

Search ClinicalTrials for Bulimia Nervosa

Search NIH Clinical Center for Bulimia Nervosa

Search CenterWatch for Bulimia Nervosa

Genetic Tests for Bulimia Nervosa

Anatomical Context for Bulimia Nervosa

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bulimia Nervosa:

33
Brain, Cortex, Heart, Thyroid, Salivary gland, Adrenal gland, Tonsil, T cells, Prefrontal cortex, Cingulate cortex, Adrenal cortex, Pituitary

Animal Models for Bulimia Nervosa or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bulimia Nervosa

Sources:
51PubMed
See all sources

Articles related to Bulimia Nervosa:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
A randomized controlled trial of psychoanalytic psychotherapy or cognitive-behavioral therapy for bulimia nervosa. (24275909)
2014
2
The efficacy of a brief group CBT program in treating patients diagnosed with bulimia nervosa: a brief report. (23568413)
2013
3
Behavioral Responses to Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa and Healthy Subjects. (24209774)
2013
4
A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder. (23790978)
2013
5
A cost effectiveness analysis of stepped care treatment for bulimia nervosa. (23354913)
2013
6
A classical case of bulimia nervosa from India. (24249937)
2013
7
Cognitive behaviour therapy response and dropout rate across purging and nonpurging bulimia nervosa and binge eating disorder: DSM-5 implications. (24200085)
2013
8
Zonisamide in the treatment of bulimia nervosa: an open-label, pilot, prospective study. (23893331)
2013
9
Unanticipated Rapid Remission of Refractory Bulimia Nervosa, during High-Dose Repetitive Transcranial Magnetic Stimulation of the Dorsomedial Prefrontal Cortex: A Case Report. (22529822)
2012
10
Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa. (22797368)
2012
11
Report weighs options for bulimia nervosa treatment. (21364132)
2011
12
Neurobiological and psychopathological variables related to emotional instability: a study of their capability to discriminate patients with bulimia nervosa from healthy controls. (21494052)
2011
13
Body schema and self-representation in patients with bulimia nervosa. (20186715)
2011
14
Cerebral venous sinus thrombosis associated with bulimia nervosa. (22707544)
2011
15
Mobile therapy: Use of text-messaging in the treatment of bulimia nervosa. (19718672)
2010
16
Quantitative evidence for distinct cognitive impairment in anorexia nervosa and bulimia nervosa. (19619407)
2010
17
The effects of exercise in obese women with bulimia nervosa. (22375209)
2010
18
Evaluation of a functional treatment for binge eating associated with bulimia nervosa. (20571313)
2010
19
Cognitive-behavioural therapy for individuals with bulimia nervosa and a co-occurring substance use disorder. (19130465)
2009
20
Modified sham feeding of sweet solutions in women with and without bulimia nervosa. (18773914)
2009
21
Negative reinforcement eating expectancies, emotion dysregulation, and symptoms of bulimia nervosa. (19172595)
2009
22
Changes of body composition in bulimia nervosa: increased visceral fat and adrenal gland size. (19124623)
2009
23
Balance in patients with anorexia and bulimia nervosa. (19221547)
2009
24
Repetitive transcranial magnetic stimulation in bulimia nervosa: preliminary results of a single-centre, randomised, double-blind, sham-controlled trial in female outpatients. (18087209)
2008
25
Effect of eating rate on binge size in Bulimia Nervosa. (17996257)
2008
26
Early response to treatment in adolescent bulimia nervosa. (18570193)
2008
27
Adverse relationship processes: the attempts of women with bulimia nervosa symptoms to fit the perceived ideal of intimate partners. (18074329)
2008
28
Emotion recognition, emotional awareness and cognitive bias in individuals with bulimia nervosa. (18473338)
2008
29
Contribution of the serotoninergic system to anxious and depressive traits that may be partially responsible for the phenotypical variability of bulimia nervosa. (17055531)
2008
30
Tobacco use and comorbidity in bulimia nervosa. (18570194)
2008
31
Therapeutic drug monitoring of plasma fluvoxamine levels for treating bulimia nervosa. (17610677)
2007
32
Subtyping adolescents with bulimia nervosa. (17949682)
2007
33
Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa. (18250619)
2007
34
Body images of patients with anorexia nervosa, bulimia nervosa and female control subjects: a comparison with male ideals of female attractiveness. (18089251)
2007
35
Neuropsychological study of underweight and "weight-recovered" anorexia nervosa compared with bulimia nervosa and normal controls. (17607697)
2007
36
Management of bulimia nervosa. (19803857)
2007
37
No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa. (16472909)
2006
38
DSM-IV threshold versus subthreshold bulimia nervosa. (16715488)
2006
39
Diagnosing bulimia nervosa with parotid swelling. Case report. (17203854)
2006
40
Changes in internal states across the binge-vomit cycle in bulimia nervosa. (16772863)
2006
41
The use of parotid gland activity analysis in patients with gastro-esophageal reflux disease (GERD) and bulimia nervosa. (17357311)
2006
42
Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. (15999344)
2005
43
Temperament and character inventory and pharmacotherapeutic outcome in bulimia nervosa. (16682854)
2005
44
Changes in body image during cognitive-behavioral treatment in women with bulimia nervosa. (18089147)
2004
45
Binge and purge processes in bulimia nervosa: a qualitative investigation. (16864514)
2003
46
A qualitative investigation of the relapse experiences of women with bulimia nervosa. (16864511)
2003
47
Identification of patients with eating disorders. The signs and symptoms of anorexia nervosa and bulimia nervosa. (17644865)
2002
48
Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. (10889521)
2000
49
Hypokalemia leading to torsades de pointes. Munchausen's disorder or bulimia nervosa? (9328782)
1997
50
Ovarian morphology and insulin sensitivity in women with bulimia nervosa. (7586620)
1995

Genetic Variations for Bulimia Nervosa

Expression for genes affiliated with Bulimia Nervosa

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bulimia Nervosa

Search GEO for disease gene expression data for Bulimia Nervosa.

Pathways for genes affiliated with Bulimia Nervosa

Sources:
38NCBI BioSystems Database, 30KEGG, 50PharmGKB, 54Reactome
See all sources

Compounds for genes affiliated with Bulimia Nervosa

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show top 50)    (show all 282)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7SLC6A4, SERPINA7
2gnrh4510.6LEPR, GHRL, PYY, BDNF
3estradiol45 11 2412.5SERPINA7, COMT, LEPR, BDNF
4citalopram50 45 11 2413.5MAOA, SLC6A4, HTR2A, HTR3A, BDNF
5sibutramine45 1111.5NPY, SLC6A4, LEP, PYY, LSL
6methysergide45 29 1112.5MAOA, HTR2A, HTR3A, HTR1B, CCK
7intralipid4510.5PYY, LSL, CCK, GHRL, LEP
8oxyntomodulin45 6011.5LEP, GHRL, NPY, CCK, PYY
9orlistat45 60 1112.4LSL, NPY, CCK, LEP, PYY, GHRL
10pramipexole45 50 29 1113.4HTR1B, BDNF, COMT, DRD4, HTR2A
11mhpg4510.4COMT, DRD4, MAOA, SLC6A4, NPY, BDNF
12fluvoxamine45 50 1112.4HTR2A, HTR3A, BDNF, SLC6A4, MAOA
13venlafaxine50 45 11 2413.4SLC6A4, BDNF, HTR1B, HTR3A, HTR2A
14ketanserin29 4511.4BDNF, HTR1B, HTR3A, HTR2A, SLC6A4
15fenfluramine29 45 1112.4CCK, HTR1B, HTR2A, NPY, LEP, SLC6A4
16fluoxetine50 45 29 1113.4HTR1B, HTR3A, HTR2A, MAOA, SLC6A4, BDNF
17maoa4510.4BDNF, HTR1B, HTR2A, DRD4, MAOA, SLC6A4
18methamphetamine45 50 1112.4SLC6A4, COMT, BDNF, NPY, DRD4, MAOA
19mcpp4510.3SLC6A4, HTR3A, HTR1B, HTR2A
20amine4510.3MAOA, MC4R, SLC6A4, HTR3A, HTR1B, PYY
21amphetamine45 1111.3NPY, PYY, CCK, DRD4, GHRL, MAOA
22yohimbine45 29 2 1113.3HTR3A, NPY, HTR2A, HTR1B, PYY
23quetiapine45 50 29 11 2414.3HTR1B, LSL, BDNF, LEP, GHRL, DRD4
24c-peptide4510.3PYY, LSL, GHRL, LEP, RETN, CCK
25pindolol45 29 1112.3HTR3A, HTR2A, SLC6A4, HTR1B
26tegaserod45 29 1112.2SLC6A4, HTR2A, HTR3A, CCK
27haloperidol45 29 2 50 1114.2HTR2A, NPY, DRD4, MC4R, SLC6A4, HTR3A
28pramlintide45 1111.2GHRL, CCK, LEP, PYY
29corticosterone45 60 2412.2SERPINA7, SLC6A4, LEPR, LEP, MC4R, GHRL
30amitriptyline45 50 29 1113.2HTR2A, HTR3A, MAOA, SLC6A4, SERPINA7
31acth4510.2MC4R, LEP, LEPR, SERPINA7, GHRL, BDNF
32epinephrine45 11 2412.2COMT, BDNF, LSL, LEP, DRD4, GHRL
33glucose4510.2SERPINA7, LEPR, PYY, CCK, LSL, NPY
34paroxetine45 50 29 1113.2GHRL, LEP, SLC6A4, MAOA, DRD4, COMT
35gaba4510.2PYY, SLC6A4, CCK, HTR3A, DRD4, GHRL
36clozapine45 29 50 1113.2HTR1B, LSL, BDNF, COMT, HTR3A, HTR2A
37thyroxine45 2411.2SERPINA7, LEPR, LEP, RETN, GHRL, NPY
38olanzapine50 45 29 11 2414.2GHRL, DRD4, HTR2A, HTR3A, HTR1B, LEPR
39methylphenidate45 50 1112.1COMT, DRD4, SLC6A4, MAOA
40norepinephrine45 11 2412.1BDNF, HTR2A, MAOA, DRD4, SLC6A4, PYY
41risperidone29 45 50 60 11 2415.1SLC6A4, LEP, GHRL, DRD4, LSL, BDNF
425-hydroxytryptamine4510.1COMT, PYY, CCK, HTR1B, HTR3A, HTR2A
43alpha msh4510.1MC4R, CCK, LEP, NPY
44cocaine45 1111.0COMT, BDNF, PYY, CCK, HTR1B, DRD4
45cholesterol45 29 11 2413.0RETN, SERPINA7, LEPR, LEP, MC4R, GHRL
46glutamate4510.0LEP, COMT, BDNF, CCK, MAOA, NPY
47arginine459.9NPY, MC4R, GHRL, LEP, LEPR, SLC6A4
48testosterone45 60 11 2412.9SERPINA7, MAOA, RETN, LEP, LEPR, SLC6A4
49dopamine45 29 11 2412.8NPY, DRD4, GHRL, MC4R, LEPR, SLC6A4
506-hydroxydopamine459.8MAOA, DRD4, NPY, BDNF, COMT

GO Terms for genes affiliated with Bulimia Nervosa

Sources:
16Gene Ontology
See all sources

Cellular components related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.2GHRL, HTR2A, HTR3A, CCK
2extracellular spaceGO:0056159.7PYY, CCK, NPY, GHRL, RETN, LEP
3extracellular regionGO:0055769.6SERPINA7, BDNF, PYY, CCK, NPY, PPY

Biological processes related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.6GHRL, NPY
2adult feeding behaviorGO:00834310.6LEP, GHRL, NPY
3dopamine catabolic processGO:04242010.6MAOA, COMT
4eating behaviorGO:04275510.6LEP, CCK, PYY
5negative regulation of appetiteGO:03209910.6LEP, CCK
6behavioral fear responseGO:00166210.6BDNF, CCK, DRD4
7feeding behaviorGO:00763110.5MC4R, NPY, PYY, BDNF
8neurotransmitter catabolic processGO:04213510.5MAOA, COMT
9negative regulation of synaptic transmission, glutamatergicGO:05196710.5HTR1B, HTR2A
10negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
11response to insulin stimulusGO:03286810.5MC4R, RETN, LEP
12regulation of dopamine secretionGO:01405910.5HTR1B, HTR2A
13digestionGO:00758610.5PYY, HTR3A, NPY, PPY
14serotonin receptor signaling pathwayGO:00721010.4HTR3A, HTR2A
15regulation of behaviorGO:05079510.4HTR1B, HTR2A
16synaptic transmissionGO:00726810.3COMT, HTR1B, HTR3A, HTR2A, NPY, MAOA
17neurotransmitter biosynthetic processGO:04213610.3MAOA, COMT
18response to vitamin AGO:03318910.2BDNF, SERPINA7
19response to drugGO:04249310.1SERPINA7, SLC6A4, HTR2A, COMT
20energy reserve metabolic processGO:0061129.9LEPR, LEP, MC4R

Molecular functions related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.3HTR2A, HTR3A, HTR1B
2neuropeptide hormone activityGO:00518410.3PYY, CCK, NPY
3drug bindingGO:00814410.2DRD4, HTR2A, HTR1B
4hormone activityGO:00517910.2LEP, RETN, PPY, CCK, PYY
5serotonin receptor activityGO:00499310.2HTR2A, HTR3A, HTR1B
6G-protein coupled receptor bindingGO:0016649.9NPY, PPY, GHRL

Products for genes affiliated with Bulimia Nervosa

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Sources for Bulimia Nervosa

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet