MCID: BLM002
MIFTS: 58

Bulimia Nervosa malady

Mental diseases, Neuronal diseases, Fetal diseases categories
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Summaries for Bulimia Nervosa

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.

MalaCards: Bulimia Nervosa, also known as bulimia nervosa, susceptibility to, is related to eating disorder and anorexia nervosa. An important gene associated with Bulimia Nervosa is BULN (Bulimia nervosa, susceptibility to), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Peptide hormone metabolism. The compounds sr 120819a and [pro...34...]npy have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are digestive/alimentary and adipose tissue.

Wikipedia:65 Bulimia nervosa is an eating disorder characterized by binge eating and purging, or consuming a large... more...

Aliases & Classifications for Bulimia Nervosa

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8Disease Ontology, 47OMIM, 45Novoseek, 9diseasecard, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

bulimia nervosa 8 47 45
bulimia nervosa, susceptibility to 9
binge eating disorder 62
hyperorexia nervosa 8


External Ids:

Disease Ontology8 DOID:12129
NCIt40 C34440
MeSH35 D002032
ICD1025 F50.2

Related Diseases for Bulimia Nervosa

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bulimia Nervosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1eating disorder31.7GHRL, LEP, PYY
2anorexia nervosa31.4LEP, NPY, CCK, PYY, BDNF, GHRL
3obesity30.8NPY, PYY, CCK, LEP, GHRL
4obsessive-compulsive disorder30.6BDNF, HTR1B
5attention deficit hyperactivity disorder30.6BDNF, HTR1B
6bipolar disorder30.4BDNF, NPY
7gastroesophageal reflux disease30.3CCK, PYY
8celiac disease30.3CCK, GHRL, PYY
9personality disorder10.7
10borderline personality disorder10.6
11blindness10.6
12cerebritis10.5
13seasonal affective disorder10.4
14avoidant personality disorder10.3
15rectal prolapse10.3
16gastric dilatation10.3
17pathological gambling10.3
18esophagitis10.3
19substance dependence10.3
20bulimia nervosa, age of onset of weight loss in10.3
21crohn's disease10.2
22antisocial personality disorder10.2
23premenstrual tension10.2
24tonsillitis10.2
25irritable bowel syndrome10.2
26hypokalemia10.2
27achalasia10.2
28hyperphosphatemia10.2
29kleptomania10.2
30graves' disease10.2
31compartment syndrome10.2
32esophageal cancer10.2
33pancreatitis10.2
34thyroiditis10.2
35cerebral atrophy10.2
36duodenogastric reflux10.1CCK
37status epilepticus10.1BDNF, NPY
38gastroparesis10.0CCK, GHRL
39temporal lobe epilepsy10.0BDNF, NPY
40dyspepsia10.0CCK, GHRL
41glucagonoma10.0GHRL, CCK
42gallbladder disease10.0PYY, CCK
43short bowel syndrome10.0CCK, PYY
44constipation10.0CCK, PYY
45psychotic disorder10.0CCK, BDNF
46thyroid medullary carcinoma10.0CCK, GHRL
47neuroepithelioma10.0CCK, NPY
48huntington's disease10.0BDNF, NPY
49autonomic neuropathy10.0NPY, CCK
50nutritional deficiency disease10.0GHRL, LEP

Graphical network of the top 20 diseases related to Bulimia Nervosa:



Diseases related to bulimia nervosa

Symptoms for Bulimia Nervosa

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Drugs & Therapeutics for Bulimia Nervosa

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bulimia Nervosa

Search NIH Clinical Center for Bulimia Nervosa

Genetic Tests for Bulimia Nervosa

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Anatomical Context for Bulimia Nervosa

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33MalaCards
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MalaCards organs/tissues related to Bulimia Nervosa:

33
Brain, Testes, Cortex, Prefrontal cortex, Pituitary, Tonsil, Adrenal gland, T cells, Thyroid, Heart, Eye, Cingulate cortex

Animal Models for Bulimia Nervosa or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bulimia Nervosa:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4LEP, GHRL, NPY, BDNF
2MP:00053758.3PYY, LEP, GHRL, NPY
3MP:00053798.1LEP, CCK, HTR1B, GHRL
4MP:00053907.9PYY, LEP, HTR1B, NPY
5MP:00053787.8BDNF, NPY, HTR1B, LEP, PYY
6MP:00036317.6BDNF, NPY, CCK, LEP, PYY
7MP:00053867.5BDNF, NPY, GHRL, HTR1B, LEP, PYY
8MP:00053767.3PYY, LEP, CCK, GHRL, NPY, BDNF

Publications for Bulimia Nervosa

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52PubMed
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Articles related to Bulimia Nervosa:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Facets of negative affect prior to and following binge-only, purge-only, and binge/purge events in women with bulimia nervosa. (22985015)
2013
2
Hard exercise, affect lability, and personality among individuals with bulimia nervosa. (24183126)
2013
3
The efficacy of a brief group CBT program in treating patients diagnosed with bulimia nervosa: a brief report. (23568413)
2013
4
Season of birth bias and bulimia nervosa--results from a multi-centre collaboration. (23338953)
2013
5
Prevalence, comorbidities and outpatient treatment of anorexia and bulimia nervosa in German children and adolescents. (23760844)
2013
6
An fMRI investigation of emotional processing of body shape in bulimia nervosa. (21312206)
2012
7
Internalizing and externalizing behaviour problems in childhood contribute to the development of anorexia and bulimia nervosa-a study comparing sister pairs. (21826764)
2012
8
Negative affect and neural response to palatable food intake in bulimia nervosa. (22387716)
2012
9
Medical complications of bulimia nervosa and their treatments. (21312201)
2011
10
COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa. (21300128)
2011
11
Ecological momentary assessment of bulimia nervosa: does dietary restriction predict binge eating? (21764036)
2011
12
An FMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa. (21676991)
2011
13
Aripiprazole in anorexia nervosa and low-weight bulimia nervosa: case reports. (20186719)
2011
14
College students' perceptions of individuals with anorexia and bulimia nervosa. (21472755)
2011
15
Weight suppression predicts time to remission from bulimia nervosa. (22004302)
2011
16
Overt and covert aggression in college women with bulimia nervosa. (22031013)
2011
17
Efficient prosthodontic treatment in a young patient with long-standing bulimia nervosa: A clinical report. (21723988)
2011
18
Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast. (20945961)
2011
19
Cognitive-behavioral therapy for subthreshold bulimia nervosa: A case series. (22290037)
2011
20
Personality pathology in purging disorder and bulimia nervosa. (21321987)
2011
21
The undue influence of shape and weight on self-evaluation in anorexia nervosa, bulimia nervosa and restrained eaters: a combined ERP and behavioral study. (20236572)
2011
22
Deliberate insulin underdosing and omission should be included in DSM-V criteria for bulimia nervosa. (20686152)
2010
23
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
24
Mobile therapy: Use of text-messaging in the treatment of bulimia nervosa. (19718672)
2010
25
Quantitative evidence for distinct cognitive impairment in anorexia nervosa and bulimia nervosa. (19619407)
2010
26
Session and intersession experience related to treatment outcome in bulimia nervosa. (22402092)
2010
27
Correlation of BDNF blood levels with interoceptive awareness and maturity fears in anorexia and bulimia nervosa patients. (20195875)
2010
28
Borderline Personality Disorder, Bulimia Nervosa, Antisocial Personality Disorder, ADHD, Substance Use: Common Threads, Common Treatment Needs, and the Nature of Impulsivity. (21253443)
2010
29
Cognitive-behavioural therapy for individuals with bulimia nervosa and a co-occurring substance use disorder. (19130465)
2009
30
Validity of the Eating Disorders Examination-Questionnaire when used with adolescents with bulimia nervosa and atypical bulimia nervosa. (20179414)
2009
31
Food cravings discriminate between anorexia and bulimia nervosa. Implications for "success" versus "failure" in dietary restriction. (19501754)
2009
32
Deficient activity in the neural systems that mediate self-regulatory control in bulimia nervosa. (19124688)
2009
33
Glucagon-like peptide-1 secretion in bulimia nervosa. (19631991)
2009
34
Bulimia nervosa and substance use disorder: similarities and differences. (18443981)
2008
35
State self-esteem ratings in women with bulimia nervosa and bulimia nervosa in remission. (18004722)
2008
36
Perceptual body image of patients with anorexia or bulimia nervosa and their fathers. (17384525)
2007
37
Esophageal cancer in a young woman with bulimia nervosa: a case report. (18047676)
2007
38
Daily and momentary mood and stress are associated with binge eating and vomiting in bulimia nervosa patients in the natural environment. (17663616)
2007
39
College students' mental models for recognizing anorexia and bulimia nervosa. (17241690)
2007
40
Anorexia nervosa patients with a prior history of bulimia nervosa. (17067877)
2006
41
Crohn's disease mimicking bulimia nervosa. (17235391)
2006
42
Affect regulation and food intake in bulimia nervosa: emotional responding to food cues after deprivation and subsequent eating. (16866597)
2006
43
The Iowa gambling task as a measure of decision making in women with bulimia nervosa. (16961954)
2006
44
Does personalized feedback improve the outcome of cognitive-behavioural guided self-care in bulimia nervosa? A preliminary randomized controlled trial. (16480570)
2006
45
Bulimia nervosa--a primary defect in the hypothalamic-pituitary-adrenal axis? (16499999)
2006
46
Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. (15999344)
2005
47
Ilse, a patient with bulimia nervosa on integrative painting therapy. Bulimia nervosa. manifestation of avoiding conflicts? (17644870)
2002
48
Central dopaminergic function in anorexia and bulimia nervosa: a psychoneuroendocrine approach. (11259859)
2001
49
Lower serum activity of prolyl endopeptidase in anorexia and bulimia nervosa. (11070331)
2001
50
Ovarian morphology and insulin sensitivity in women with bulimia nervosa. (7586620)
1995

Variations for Bulimia Nervosa

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Expression for genes affiliated with Bulimia Nervosa

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bulimia Nervosa

Search GEO for disease gene expression data for Bulimia Nervosa.

Pathways for genes affiliated with Bulimia Nervosa

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Sources:
50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Bulimia Nervosa

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Sources:
45Novoseek, 3BitterDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1sr 120819a459.6PYY, NPY
2[pro...34...]npy459.6PYY, NPY
3[met]enkephalin459.6CCK, NPY
4octadecaneuropeptide459.3GHRL, CCK, NPY
5yohimbine45 3 29 1112.2NPY, PYY, HTR1B
6incretin459.1PYY, CCK, NPY
7rimonabant45 29 1111.0CCK, LEP, GHRL
8sibutramine45 119.9NPY, LEP, PYY
9enterostatin458.9NPY, LEP, CCK
10alpha msh458.8NPY, CCK, LEP
11paroxetine45 51 29 1111.8HTR1B, LEP, BDNF, GHRL
12quetiapine45 51 29 24 1112.8HTR1B, LEP, BDNF, GHRL
13risperidone45 51 29 61 24 1113.8BDNF, GHRL, HTR1B, LEP
14tetrodotoxin45 61 2910.8PYY, BDNF, NPY, CCK
15amphetamine45 51 1110.8CCK, GHRL, NPY, PYY
16octreotide45 61 29 1111.8GHRL, CCK, PYY, NPY
17olanzapine45 51 29 24 1112.8GHRL, LEP, HTR1B, BDNF
18atropine45 29 1110.8GHRL, PYY, NPY, CCK
19capsaicin45 299.7LEP, GHRL, BDNF, NPY
20clozapine45 29 51 1111.7BDNF, LEP, HTR1B, GHRL
21naloxone45 29 51 1111.7GHRL, CCK, LEP
22corticosterone45 61 2410.7BDNF, NPY, GHRL, LEP
23nifedipine45 29 51 1111.6NPY, BDNF, GHRL, LEP
24l-nmma458.6CCK, GHRL, LEP
25clonidine45 51 29 1111.6LEP, NPY, PYY
26pramlintide45 119.5PYY, GHRL, CCK, LEP
27intralipid458.5GHRL, CCK, PYY, LEP
28epinephrine45 24 1110.5NPY, LEP, GHRL, BDNF
29fenfluramine45 29 1110.5LEP, CCK, HTR1B, NPY
30c-peptide458.5GHRL, CCK, LEP, PYY
31cyclic amp45 249.5NPY, PYY, HTR1B, BDNF, GHRL
32carbachol45 29 1110.5GHRL, CCK, PYY, NPY, BDNF
33histamine45 29 2410.4NPY, BDNF, PYY, GHRL, CCK
345-hydroxytryptamine458.4NPY, HTR1B, CCK, GHRL, PYY
35gnrh458.2LEP, GHRL, BDNF, NPY, PYY
36oxyntomodulin45 619.0CCK, NPY, GHRL, PYY, LEP
37orlistat45 61 1110.0LEP, GHRL, NPY, CCK, PYY
38carbohydrates458.0PYY, NPY, LEP, CCK, GHRL
39dopamine45 29 24 1111.0BDNF, HTR1B, GHRL, CCK, NPY, PYY
40cholesterol45 29 24 1111.0BDNF, PYY, LEP, CCK, GHRL
41arginine457.7PYY, LEP, CCK, GHRL, NPY
42testosterone45 61 24 1110.7CCK, LEP, HTR1B, GHRL, NPY, BDNF
43acth457.6NPY, BDNF, GHRL, LEP, CCK, PYY
44gaba457.6BDNF, NPY, GHRL, PYY, CCK, LEP
45norepinephrine45 24 119.6NPY, GHRL, CCK, LEP, PYY, BDNF
46acetylcholine45 51 29 24 1111.6GHRL, PYY, LEP, CCK, NPY, BDNF
47glucose457.5CCK, NPY, LEP, GHRL, BDNF, PYY
48tyrosine457.5NPY, GHRL, HTR1B, CCK, BDNF, PYY
49glutamate457.4LEP, CCK, BDNF, NPY, GHRL
50cocaine45 118.2GHRL, PYY, BDNF, NPY, LEP, CCK

GO Terms for genes affiliated with Bulimia Nervosa

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16Gene Ontology
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Cellular components related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.6NPY, GHRL, CCK, LEP, PYY
2extracellular regionGO:0055766.9BDNF, PYY, LEP, CCK, GHRL, NPY

Biological processes related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synapse assemblyGO:0519659.9BDNF, GHRL
2regulation of excitatory postsynaptic membrane potentialGO:0600799.9BDNF, GHRL
3dendrite developmentGO:0163589.8GHRL, BDNF
4positive regulation of appetiteGO:0321009.8NPY, GHRL
5response to hormoneGO:0097259.7BDNF, GHRL
6behavioral fear responseGO:0016629.6BDNF, CCK
7protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.5HTR1B, CCK
8G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.4HTR1B, NPY
9central nervous system neuron developmentGO:0219549.4LEP, NPY
10feeding behaviorGO:0076319.3PYY, BDNF, NPY
11negative regulation of appetiteGO:0320999.3CCK, LEP
12digestionGO:0075869.1PYY, NPY
13regulation of blood pressureGO:0082179.1NPY, LEP
14adult feeding behaviorGO:0083439.0NPY, GHRL, LEP
15eating behaviorGO:0427558.8PYY, LEP, CCK

Molecular functions related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor bindingGO:0016649.5NPY, GHRL
2neuropeptide hormone activityGO:0051848.7NPY, CCK, PYY
3hormone activityGO:0051798.2CCK, LEP, PYY

Products for genes affiliated with Bulimia Nervosa

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Sources for Bulimia Nervosa

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet