MCID: BLM002
MIFTS: 62

Bulimia Nervosa malady

Neuronal diseases category

Summaries for Bulimia Nervosa

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.

MalaCards: Bulimia Nervosa, also known as bulimia nervosa, susceptibility to, is related to anorexia nervosa and eating disorder. An important gene associated with Bulimia Nervosa is BULN (Bulimia nervosa, susceptibility to), and among its related pathways are phenylalanine utilization and Adipocytokine signaling pathway. The compounds estrogen and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:63 Bulimia nervosa is an eating disorder characterized by binge eating and purging, or consuming a large... more...

Aliases & Classifications for Bulimia Nervosa

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8Disease Ontology, 46OMIM, 44Novoseek, 9diseasecard, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bulimia nervosa 8 46 44
bulimia nervosa, susceptibility to 9
binge eating disorder 60
hyperorexia nervosa 8


External Ids:

Disease Ontology8 DOID:12129
MeSH34 D002032
NCIt39 C34440
ICD1025 F50.2

Related Diseases for Bulimia Nervosa

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bulimia Nervosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa31.8HTR2A, BDNF
2eating disorder31.6SLC6A4, LEPR, LEP, RETN, MC4R, GHRL
3personality disorder31.0SLC6A4, MAOA, DRD4, HTR1B
4obesity30.9LEPR, LEP, RETN, MC4R, MAOA, GHRL
5borderline personality disorder30.9SLC6A4, MAOA, HTR1B
6morbid obesity30.7LEPR, LEP, RETN, MC4R, GHRL, LSL
7anxiety disorder30.6SLC6A4, MAOA, NPY, HTR2A, HTR3A, CCK
8seasonal affective disorder30.5SLC6A4, DRD4, HTR2A
9obsessive-compulsive disorder30.5SLC6A4, MAOA, DRD4, HTR2A, HTR3A, HTR1B
10pathological gambling30.4DRD4
11substance dependence30.4SLC6A4, DRD4, COMT
12attention deficit hyperactivity disorder30.4SLC6A4, MAOA, DRD4, HTR2A, HTR1B, BDNF
13mood disorder30.4SLC6A4, MAOA, DRD4, NPY, HTR2A, HTR3A
14type 2 diabetes mellitus30.3LEPR, LEP, RETN, MC4R, GHRL, HTR2A
15diabetes mellitus30.3LEPR, LEP, RETN, MC4R, GHRL, PPY
16thyroiditis30.2SERPINA7
17pancreatitis30.2PPY, CCK
18irritable bowel syndrome30.2SLC6A4, HTR3A, CCK
19bipolar disorder30.2SLC6A4, BDNF
20antisocial personality disorder30.2SLC6A4, MAOA, HTR2A, HTR1B
21celiac disease30.2GHRL, CCK, PYY
22cerebritis10.4
23alexithymia10.4
24physical disorder10.4
25avoidant personality disorder10.3
26gastric dilatation10.3
27rectal prolapse10.3
28esophagitis10.3
29bulimia nervosa, age of onset of weight loss in10.3
30adjustment disorder10.2
31double outlet right ventricle10.2
32intestinal disease10.2
33sleep disorder10.2
34crohn's disease10.1
35achalasia10.1
36hyperphosphatemia10.1
37obsessive-compulsive personality disorder10.1
38pain disorder10.1
39premenstrual tension10.1
40gastroesophageal reflux disease10.1
41tonsillitis10.1
42hypokalemia10.1
43kleptomania10.1
44graves' disease10.1
45compartment syndrome10.1
46esophageal cancer10.1
47esophageal disease10.1
48parotid disease10.1
49sexual disorder10.1
50neuroblastoma10.0BDNF

Graphical network of the top 20 diseases related to Bulimia Nervosa:



Diseases related to bulimia nervosa

Clinical Features for Bulimia Nervosa

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Drugs & Therapeutics for Bulimia Nervosa

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bulimia Nervosa

Drug clinical trials:

Search ClinicalTrials for Bulimia Nervosa

Search NIH Clinical Center for Bulimia Nervosa

Search CenterWatch for Bulimia Nervosa

Genetic Tests for Bulimia Nervosa

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Anatomical Context for Bulimia Nervosa

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32MalaCards
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MalaCards organs/tissues related to Bulimia Nervosa:

32
Brain, Testes, Cortex, Cingulate cortex, Prefrontal cortex, T cells, Tonsil, Eye, Adrenal gland, Thyroid, Heart, Pituitary

Animal Models for Bulimia Nervosa or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bulimia Nervosa:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2PYY, MC4R, RETN
2MP:00053799.8CCK, HTR1B, HTR3A, HTR2A, GHRL, LEP
3MP:00053789.7PYY, HTR1B, HTR3A, NPY, PPY, MC4R
4MP:00036319.6COMT, BDNF, PYY, CCK, HTR3A, NPY
5MP:00053909.6PYY, HTR1B, HTR2A, NPY, PPY, MC4R
6MP:00053769.5NPY, HTR3A, CCK, PYY, BDNF, COMT
7MP:00053869.5SLC6A4, COMT, BDNF, PYY, HTR1B, HTR3A

Publications for Bulimia Nervosa

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Sources:
50PubMed
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Articles related to Bulimia Nervosa:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Weight suppression in bulimia nervosa: relationship with cognitive behavioral therapy outcome. (23606241)
2013
2
Brain responses to body image stimuli but not food are altered in women with bulimia nervosa. (24238299)
2013
3
Does anger mediate between personality and eating symptoms in bulimia nervosa? (22944222)
2012
4
A cross-sectional analysis of the cognitive model of bulimia nervosa. (22407509)
2012
5
Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa. (22681985)
2012
6
Successful "detoxing" from commonly utilized modes of purging in bulimia nervosa. (22703572)
2012
7
Comparison of obese and nonobese individuals with binge eating disorder: delicate boundary between binge eating disorder and non-purging bulimia nervosa. (22492565)
2012
8
An experimental investigation of verbal expression of emotion in anorexia and bulimia nervosa. (21948284)
2012
9
Overt and covert aggression in college women with bulimia nervosa. (22031013)
2011
10
Efficient prosthodontic treatment in a young patient with long-standing bulimia nervosa: A clinical report. (21723988)
2011
11
Neural correlates of the processing of self-referent emotional information in bulimia nervosa. (21843538)
2011
12
Electrocortical processing of food and emotional pictures in anorexia nervosa and bulimia nervosa. (21493952)
2011
13
Reward abnormalities among women with full and subthreshold bulimia nervosa: a functional magnetic resonance imaging study. (21997421)
2011
14
Deliberate insulin underdosing and omission should be included in DSM-V criteria for bulimia nervosa. (20686152)
2010
15
Session and intersession experience related to treatment outcome in bulimia nervosa. (22402092)
2010
16
Bulimia nervosa symptoms in the multimodal treatment study of children with ADHD. (19378318)
2010
17
Altered striatal response to reward in bulimia nervosa after recovery. (19434606)
2010
18
Client experience of psychodynamic psychotherapy for bulimia nervosa: an interview study. (21198236)
2010
19
Personality dimensions in bulimia nervosa, binge eating disorder, and obesity. (19932823)
2010
20
Preliminary evidence for a role for impulsivity in cognitive disinhibition in bulimia nervosa. (20524223)
2010
21
Are single-parent families different from two-parent families in the treatment of adolescent bulimia nervosa using family-based treatment? (18720474)
2009
22
Frequency of binge eating episodes in bulimia nervosa and binge eating disorder: Diagnostic considerations. (19610014)
2009
23
Affective lability and impulsivity in a clinical sample of women with bulimia nervosa: the role of affect in severely dysregulated behavior. (18951460)
2009
24
Increased mortality in bulimia nervosa and other eating disorders. (19833789)
2009
25
Cognitive behavioral approaches in adolescent anorexia and bulimia nervosa. (19014863)
2009
26
Inpatient versus day treatment for bulimia nervosa: results of a one-year follow-up. (19628960)
2009
27
The outcome of bulimia nervosa: findings from one-quarter century of research. (19884225)
2009
28
A randomised trial investigating guided self-help to reduce perfectionism and its impact on bulimia nervosa: a pilot study. (19007923)
2008
29
Invalidating childhood environments in anorexia and bulimia nervosa. (18549990)
2008
30
Parental psychopathology as a predictor of long-term outcome in bulimia nervosa patients. (18175231)
2008
31
Do adolescents with eating disorder not otherwise specified or full-syndrome bulimia nervosa differ in clinical severity, comorbidity, risk factors, treatment outcome or cost? (18433024)
2008
32
Internal consistency and validity of the BITE for the screening of bulimia nervosa in university students, Colombia. (18612252)
2008
33
Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V. (18198267)
2008
34
Treatment of bulimia nervosa. (18581841)
2008
35
Esophageal cancer in a young woman with bulimia nervosa: a case report. (18047676)
2007
36
College students' mental models for recognizing anorexia and bulimia nervosa. (17241690)
2007
37
A Dutch day treatment program for anorexia and bulimia nervosa in comparison with internationally described programs. (17676678)
2007
38
Association between broadly defined bulimia nervosa and drug use disorders: common genetic and environmental influences. (17868121)
2007
39
Ovarian hormones and binge eating in bulimia nervosa. (17038206)
2007
40
Motivation to change in recent onset and long-standing bulimia nervosa: are there differences? (17615490)
2007
41
The effects of childhood trauma on daily mood lability and comorbid psychopathology in bulimia nervosa. (17345648)
2007
42
Neuropsychological correlates of decision making in patients with bulimia nervosa. (17983288)
2007
43
An objective means of diagnosing anorexia nervosa and bulimia nervosa using 15N/14N and 13C/12C ratios in hair. (17044129)
2006
44
Differential motivational responses to food and pleasurable cues in anorexia and bulimia nervosa: a startle reflex paradigm. (16790080)
2006
45
Citalopram versus fluoxetine for the treatment of patients with bulimia nervosa: a single-blind randomized controlled trial. (16912031)
2006
46
Blindness and bulimia nervosa: a description of a case report and its treatment. (16498584)
2006
47
Medical complications of anorexia nervosa and bulimia nervosa. (16721178)
2006
48
What treatment data support topiramate in bulimia nervosa and binge eating disorder? What is the drug's safety profile? How is it used in these conditions? (16864288)
2003
49
Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa. (11690602)
2001
50
Serum leptin and body weight in females with anorexia and bulimia nervosa. (9660088)
1998

Genetic Variations for Bulimia Nervosa

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Expression for genes affiliated with Bulimia Nervosa

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bulimia Nervosa

Search GEO for disease gene expression data for Bulimia Nervosa.

Pathways for genes affiliated with Bulimia Nervosa

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Sources:
37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Bulimia Nervosa

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show top 50)    (show all 282)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7SLC6A4, SERPINA7
2gnrh4410.6LEPR, GHRL, PYY, BDNF
3estradiol44 11 2412.5SERPINA7, COMT, LEPR, BDNF
4citalopram49 44 11 2413.5MAOA, SLC6A4, HTR2A, HTR3A, BDNF
5sibutramine44 1111.5NPY, SLC6A4, LEP, PYY, LSL
6methysergide44 28 1112.5MAOA, HTR2A, HTR3A, HTR1B, CCK
7intralipid4410.5PYY, LSL, CCK, GHRL, LEP
8oxyntomodulin44 5911.5LEP, GHRL, NPY, CCK, PYY
9orlistat44 59 1112.4LSL, NPY, CCK, LEP, PYY, GHRL
10pramipexole44 49 28 1113.4HTR1B, BDNF, COMT, DRD4, HTR2A
11mhpg4410.4COMT, DRD4, MAOA, SLC6A4, NPY, BDNF
12fluvoxamine44 49 1112.4HTR2A, HTR3A, BDNF, SLC6A4, MAOA
13venlafaxine49 44 11 2413.4SLC6A4, BDNF, HTR1B, HTR3A, HTR2A
14ketanserin28 4411.4BDNF, HTR1B, HTR3A, HTR2A, SLC6A4
15fenfluramine28 44 1112.4CCK, HTR1B, HTR2A, NPY, LEP, SLC6A4
16fluoxetine49 44 28 1113.4HTR1B, HTR3A, HTR2A, MAOA, SLC6A4, BDNF
17maoa4410.4BDNF, HTR1B, HTR2A, DRD4, MAOA, SLC6A4
18methamphetamine44 49 1112.4SLC6A4, COMT, BDNF, NPY, DRD4, MAOA
19mcpp4410.3SLC6A4, HTR3A, HTR1B, HTR2A
20amine4410.3MAOA, MC4R, SLC6A4, HTR3A, HTR1B, PYY
21amphetamine44 1111.3NPY, PYY, CCK, DRD4, GHRL, MAOA
22yohimbine44 28 2 1113.3HTR3A, NPY, HTR2A, HTR1B, PYY
23quetiapine44 49 28 11 2414.3HTR1B, LSL, BDNF, LEP, GHRL, DRD4
24c-peptide4410.3PYY, LSL, GHRL, LEP, RETN, CCK
25pindolol44 28 1112.3HTR3A, HTR2A, SLC6A4, HTR1B
26tegaserod44 28 1112.2SLC6A4, HTR2A, HTR3A, CCK
27haloperidol44 28 2 49 1114.2HTR2A, NPY, DRD4, MC4R, SLC6A4, HTR3A
28pramlintide44 1111.2GHRL, CCK, LEP, PYY
29corticosterone44 59 2412.2SERPINA7, SLC6A4, LEPR, LEP, MC4R, GHRL
30amitriptyline44 49 28 1113.2HTR2A, HTR3A, MAOA, SLC6A4, SERPINA7
31acth4410.2MC4R, LEP, LEPR, SERPINA7, GHRL, BDNF
32epinephrine44 11 2412.2COMT, BDNF, LSL, LEP, DRD4, GHRL
33glucose4410.2SERPINA7, LEPR, PYY, CCK, LSL, NPY
34paroxetine44 49 28 1113.2GHRL, LEP, SLC6A4, MAOA, DRD4, COMT
35gaba4410.2PYY, SLC6A4, CCK, HTR3A, DRD4, GHRL
36clozapine44 28 49 1113.2HTR1B, LSL, BDNF, COMT, HTR3A, HTR2A
37thyroxine44 2411.2SERPINA7, LEPR, LEP, RETN, GHRL, NPY
38olanzapine49 44 28 11 2414.2GHRL, DRD4, HTR2A, HTR3A, HTR1B, LEPR
39methylphenidate44 49 1112.1COMT, DRD4, SLC6A4, MAOA
40norepinephrine44 11 2412.1BDNF, HTR2A, MAOA, DRD4, SLC6A4, PYY
41risperidone28 44 49 59 11 2415.1SLC6A4, LEP, GHRL, DRD4, LSL, BDNF
425-hydroxytryptamine4410.1COMT, PYY, CCK, HTR1B, HTR3A, HTR2A
43alpha msh4410.1MC4R, CCK, LEP, NPY
44cocaine44 1111.0COMT, BDNF, PYY, CCK, HTR1B, DRD4
45cholesterol44 28 11 2413.0RETN, SERPINA7, LEPR, LEP, MC4R, GHRL
46glutamate4410.0LEP, COMT, BDNF, CCK, MAOA, NPY
47arginine449.9NPY, MC4R, GHRL, LEP, LEPR, SLC6A4
48testosterone44 59 11 2412.9SERPINA7, MAOA, RETN, LEP, LEPR, SLC6A4
49dopamine44 28 11 2412.8NPY, DRD4, GHRL, MC4R, LEPR, SLC6A4
506-hydroxydopamine449.8MAOA, DRD4, NPY, BDNF, COMT

GO Terms for genes affiliated with Bulimia Nervosa

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16Gene Ontology
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Cellular components related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.2GHRL, HTR2A, HTR3A, CCK
2extracellular spaceGO:0056159.7PYY, CCK, NPY, GHRL, RETN, LEP
3extracellular regionGO:0055769.6SERPINA7, BDNF, PYY, CCK, NPY, PPY

Biological processes related to Bulimia Nervosa according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.6GHRL, NPY
2adult feeding behaviorGO:00834310.6LEP, GHRL, NPY
3dopamine catabolic processGO:04242010.6MAOA, COMT
4eating behaviorGO:04275510.6LEP, CCK, PYY
5negative regulation of appetiteGO:03209910.6LEP, CCK
6behavioral fear responseGO:00166210.6BDNF, CCK, DRD4
7feeding behaviorGO:00763110.5MC4R, NPY, PYY, BDNF
8neurotransmitter catabolic processGO:04213510.5MAOA, COMT
9negative regulation of synaptic transmission, glutamatergicGO:05196710.5HTR1B, HTR2A
10negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
11response to insulin stimulusGO:03286810.5MC4R, RETN, LEP
12regulation of dopamine secretionGO:01405910.5HTR1B, HTR2A
13digestionGO:00758610.5PYY, HTR3A, NPY, PPY
14serotonin receptor signaling pathwayGO:00721010.4HTR3A, HTR2A
15regulation of behaviorGO:05079510.4HTR1B, HTR2A
16synaptic transmissionGO:00726810.3COMT, HTR1B, HTR3A, HTR2A, NPY, MAOA
17neurotransmitter biosynthetic processGO:04213610.3MAOA, COMT
18response to vitamin AGO:03318910.2BDNF, SERPINA7
19response to drugGO:04249310.1SERPINA7, SLC6A4, HTR2A, COMT
20energy reserve metabolic processGO:0061129.9LEPR, LEP, MC4R

Molecular functions related to Bulimia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.3HTR2A, HTR3A, HTR1B
2neuropeptide hormone activityGO:00518410.3PYY, CCK, NPY
3drug bindingGO:00814410.2DRD4, HTR2A, HTR1B
4hormone activityGO:00517910.2LEP, RETN, PPY, CCK, PYY
5serotonin receptor activityGO:00499310.2HTR2A, HTR3A, HTR1B
6G-protein coupled receptor bindingGO:0016649.9NPY, PPY, GHRL

Products for genes affiliated with Bulimia Nervosa

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  • Antibodies
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Sources for Bulimia Nervosa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet