MCID: BLL012
MIFTS: 40

Bullous Impetigo

Categories: Skin diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Bullous Impetigo

MalaCards integrated aliases for Bullous Impetigo:

Name: Bullous Impetigo 55 51 69

Characteristics:

Orphanet epidemiological data:

55
bullous impetigo
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



Summaries for Bullous Impetigo

MalaCards based summary : Bullous Impetigo is related to impetigo and ritter's disease, and has symptoms including septic arthritis, recurrent bacterial skin infections and abnormal blistering of the skin. An important gene associated with Bullous Impetigo is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Pathways in cancer and Apoptotic cleavage of cellular proteins. Affiliated tissues include skin, and related phenotypes are integument and digestive/alimentary

Wikipedia : 72 Bullous Impetigo is a skin condition that characteristically occurs in the newborn, and is caused by a... more...

Related Diseases for Bullous Impetigo

Diseases related to Bullous Impetigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 impetigo 31.4 CALCA DSG1 EDNRB IL6
2 ritter's disease 31.0 DSG1 EDNRA EDNRB
3 pemphigus 30.3 DSG1 DSG3
4 pemphigus foliaceus 30.1 DSG1 DSG3
5 toxic shock syndrome 29.8 EDNRA IL6
6 osteitis fibrosa 10.1 CALCA IL6
7 esophagitis 10.1 DSG1 IL6
8 herpetiform pemphigus 10.1 DSG1 DSG3
9 nodular goiter 10.1 CALCA IL6
10 complex regional pain syndrome 10.1 CALCA IL6
11 netherton syndrome 10.1 DSG1 EDNRA
12 nodular malignant melanoma 10.1 DSG1 DSG3
13 miliaria 10.1
14 miliaria rubra 10.1
15 bullous skin disease 10.1 DSG1 DSG3
16 bone resorption disease 10.1 CALCA IL6
17 subcorneal pustular dermatosis 10.1 DSG1 DSG3
18 paraneoplastic pemphigus 10.0 DSG1 DSG3
19 headache 10.0 CALCA EDNRA
20 pemphigus vulgaris 10.0 DSG1 DSG3
21 herpes simplex 10.0
22 bullous pemphigoid 9.9 DSG1 DSG3
23 perinephritis 9.9 EDNRA EDNRB
24 scarlet fever 9.9 EDNRA EDNRB
25 radiation proctitis 9.9 EDNRA EDNRB
26 multiple endocrine neoplasia, type iib 9.9 CALCA EDNRB
27 autonomic nervous system disease 9.9 CALCA EDNRB
28 dermatitis 9.8
29 neonatal herpes 9.8
30 pyogenic granuloma 9.8
31 streptococcal toxic-shock syndrome 9.8
32 dermatitis, atopic 9.8
33 hepatopulmonary syndrome 9.8 EDNRA EDNRB
34 intestinal disease 9.8 EDNRB IL6
35 thyroid carcinoma, familial medullary 9.6 CALCA EDNRB
36 gastrointestinal system disease 9.6 EDNRB IL6
37 chronic kidney failure 9.6 CALCA IL6
38 commensal bacterial infectious disease 9.6 DSG1 EDNRB IL6
39 autosomal dominant polycystic kidney disease 9.5 EDNRA EDNRB
40 migraine with or without aura 1 9.5 CALCA EDNRA EDNRB
41 heart disease 9.3 EDNRA EDNRB IL6
42 pulmonary hypertension 9.2 CALCA EDNRA EDNRB IL6

Graphical network of the top 20 diseases related to Bullous Impetigo:



Diseases related to Bullous Impetigo

Symptoms & Phenotypes for Bullous Impetigo

Human phenotypes related to Bullous Impetigo:

55 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 septic arthritis 55 31 occasional (7.5%) Occasional (29-5%) HP:0003095
2 recurrent bacterial skin infections 55 31 hallmark (90%) Very frequent (99-80%) HP:0005406
3 abnormal blistering of the skin 55 31 hallmark (90%) Very frequent (99-80%) HP:0008066
4 erythema 55 31 hallmark (90%) Very frequent (99-80%) HP:0010783
5 abnormality of the lymphatic system 55 31 occasional (7.5%) Occasional (29-5%) HP:0100763
6 sepsis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100806
7 glomerulopathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0100820
8 pustule 55 31 hallmark (90%) Very frequent (99-80%) HP:0200039

MGI Mouse Phenotypes related to Bullous Impetigo:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.65 DSG1 DSG3 EDNRA EDNRB IL6
2 digestive/alimentary MP:0005381 9.62 EDNRA EDNRB IL6 DSG3
3 respiratory system MP:0005388 9.46 DSG3 EDNRA EDNRB IL6
4 skeleton MP:0005390 9.35 DSG1 DSG3 EDNRA EDNRB IL6
5 vision/eye MP:0005391 9.02 DSG1 DSG3 EDNRA EDNRB IL6

Drugs & Therapeutics for Bullous Impetigo

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT02090764 Phase 3 Ozenoxacin;Placebo
2 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT01397461 Phase 3 ozenoxacin placebo;retapamulin 1% ointment;ozenoxacin 1% cream
3 Study Evaluating the Safety, Tolerability, PK, and Activity of Topical ATx201 Gel in Outpatients With Impetigo Not yet recruiting NCT03429595 Phase 2 ATx201

Search NIH Clinical Center for Bullous Impetigo

Genetic Tests for Bullous Impetigo

Anatomical Context for Bullous Impetigo

MalaCards organs/tissues related to Bullous Impetigo:

38
Skin

Publications for Bullous Impetigo

Articles related to Bullous Impetigo:

(show top 50) (show all 55)
# Title Authors Year
1
Bullous impetigo during interstitial pneumonitis. ( 29050448 )
2017
2
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
3
Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy. ( 27617460 )
2016
4
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. ( 26603272 )
2016
5
Staphylococcal bullous impetigo in a neonate. ( 27458596 )
2016
6
Bullous Impetigo Rapid Diagnostic and Therapeutic Quiz: A Model for Assessing Basic Dermatology Knowledge of Primary Care Providers. ( 27599660 )
2016
7
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. ( 25298068 )
2014
8
Bullous impetigo. ( 24736928 )
2014
9
Paediatric bullous dermatoses. Linear immunoglobulin A (IgA) dermatosis. Bullous impetigo. Bullous insect bite reaction. Neonatal Herpes simplex virus (HSV) infection. ( 23111154 )
2013
10
The use of typing methods and infection prevention measures to control a bullous impetigo outbreak on a neonatal ward. ( 23168170 )
2012
11
Outbreak of bullous impetigo caused by Staphylococcus aureus strains of phage type 3C/71 in a maternity ward linked to nasal carriage of a healthcare worker. ( 22378195 )
2012
12
Bullous impetigo associated with Abiotrophia defectiva in an immunocompetent adult. ( 22493280 )
2012
13
Bullous impetigo in children infected with methicillin-resistant Staphylococcus aureus alone or in combination with methicillin-susceptible S. aureus: analysis of genetic characteristics, including assessment of exfoliative toxin gene carriage. ( 21430094 )
2011
14
Dermacase. Bullous impetigo. ( 18272632 )
2008
15
Is blistering distal dactylitis a variant of bullous impetigo? ( 17362240 )
2007
16
Outbreak of staphylococcal bullous impetigo in a maternity ward linked to an asymptomatic healthcare worker. ( 17945394 )
2007
17
Bullous impetigo: a rare presentation in fulminant streptococcal toxic shock syndrome. ( 17505275 )
2007
18
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. ( 17065642 )
2006
19
Review: topical mupirocin or fusidic acid may be more effective than oral antibiotics for limited non-bullous impetigo. ( 15688485 )
2005
20
Bullous impetigo of the face after epilation by threading. ( 16172329 )
2005
21
Desmosomes and disease: pemphigus and bullous impetigo. ( 15363804 )
2004
22
Generalized bullous impetigo in a neonate. ( 15575854 )
2004
23
Treatment of bullous impetigo and the staphylococcal scalded skin syndrome in infants. ( 15482208 )
2004
24
Confocal laser scanning microscopic observation of glycocalyx production by Staphylococcus aureus in skin lesions of bullous impetigo, atopic dermatitis and pemphigus foliaceus. ( 12653745 )
2003
25
Clinicopathological case 3: pemphigus foliaceus; bullous impetigo; subcorneal pustular dermatoses. ( 12823325 )
2003
26
Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan. ( 11992289 )
2002
27
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. ( 12093888 )
2002
28
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. ( 11062541 )
2000
29
Bullous impetigo. ( 9369884 )
1997
30
Vesicles and bulla in an infant. Bullous varicella (chicken pox complicated by bullous impetigo). ( 8285728 )
1994
31
Bullous impetigo in homosexual men--a risk marker for HIV-1 infection? ( 1607190 )
1992
32
Bullous impetigo caused by group A streptococci. A case report. ( 1350146 )
1992
33
Is penicillin still the drug of choice for non-bullous impetigo? ( 1681172 )
1991
34
Bullous impetigo and localized scalded skin syndrome in the elderly. ( 3623889 )
1987
35
Antibiotic susceptibilities of Staphylococcus aureus strains derived from furuncle and bullous impetigo. ( 3894459 )
1985
36
Vacuoles in the upper part of the epidermis as a clue to eventuation of superficial pemphigus and bullous impetigo. ( 6731731 )
1984
37
Effects of serum albumin on coagulase release from Staphylococcus aureus derived from bullous impetigo. ( 6386912 )
1984
38
What histologic finding distinguishes superficial pemphigus and bullous impetigo? ( 6375421 )
1984
39
Epidemic bullous impetigo in a nursery due to a nasal carrier of Staphylococcus aureus: role of epidemiology and control measures. ( 6376403 )
1984
40
Re-emergence of bullous impetigo. ( 6799136 )
1982
41
Sequential bullous impetigo and cutaneous Herpes simplex virus infection. ( 6761658 )
1982
42
Re-emergence of bullous impetigo. ( 6799044 )
1981
43
Falsely normal direct immunofluorescent microscopic fundings in bullous impetigo. ( 7027964 )
1981
44
Bullous impetigo caused by Streptococcus salivarius: a case report. ( 7002959 )
1980
45
The epidermolytic toxin of Staphylococcus aureus: its failure to bind to cells and its detection in blister fluids of patients with bullous impetigo. ( 701847 )
1978
46
Staphylococcal scalded skin syndrome. II. Serum level of anti exfoliatin and anti alpha-toxin in patients with staphylococcal scalded skin syndrome or bullous impetigo. ( 15461328 )
1977
47
Bullous impetigo. Occurrence of localized scalded skin syndrome in an adult. ( 782365 )
1976
48
Skin complications of heroin addiction. Bullous impetigo. ( 4513637 )
1973
49
An epidemic of bullous impetigo arising from a central admission-observation nursery. ( 5059306 )
1972
50
Bullous impetigo due to group II Staphylococcus aureus. An epidemic in a normal newborn nursery. ( 5422851 )
1970

Variations for Bullous Impetigo

Expression for Bullous Impetigo

Search GEO for disease gene expression data for Bullous Impetigo.

Pathways for Bullous Impetigo

GO Terms for Bullous Impetigo

Cellular components related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 DSG1 DSG3
2 desmosome GO:0030057 8.62 DSG1 DSG3

Biological processes related to Bullous Impetigo according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.49 DSG1 DSG3
2 monocyte chemotaxis GO:0002548 9.48 CALCA IL6
3 activation of adenylate cyclase activity GO:0007190 9.46 CALCA EDNRA
4 vasodilation GO:0042311 9.43 CALCA EDNRB
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.43 CALCA EDNRA EDNRB
6 response to pain GO:0048265 9.4 CALCA EDNRB
7 vasoconstriction GO:0042310 9.37 EDNRA EDNRB
8 negative regulation of bone resorption GO:0045779 9.32 CALCA IL6
9 enteric nervous system development GO:0048484 9.16 EDNRA EDNRB
10 regulation of blood pressure GO:0008217 9.13 CALCA EDNRA EDNRB
11 endothelin receptor signaling pathway GO:0086100 8.62 EDNRA EDNRB

Molecular functions related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Bullous Impetigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....