MCID: BLL012
MIFTS: 37

Bullous Impetigo

Categories: Skin diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Bullous Impetigo

MalaCards integrated aliases for Bullous Impetigo:

Name: Bullous Impetigo 56 52 69

Characteristics:

Orphanet epidemiological data:

56
bullous impetigo
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



Summaries for Bullous Impetigo

MalaCards based summary : Bullous Impetigo is related to impetigo and conjunctival concretion, and has symptoms including septic arthritis, recurrent bacterial skin infections and abnormal blistering of the skin. An important gene associated with Bullous Impetigo is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Pathways in cancer and Apoptotic cleavage of cellular proteins. Affiliated tissues include skin, and related phenotypes are digestive/alimentary and integument

Wikipedia : 72 Bullous Impetigo is a skin condition that characteristically occurs in the newborn, and is caused by a... more...

Related Diseases for Bullous Impetigo

Diseases related to Bullous Impetigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 impetigo 11.6
2 conjunctival concretion 10.2 DSG1 IL6
3 nodular prostate 10.2 CALCA IL6
4 intellectual disability-short stature-hypertelorism syndrome 10.2 DSG1 DSG3
5 high pressure neurological syndrome 10.2 CALCA IL6
6 peri-anal fistula 10.2 DSG1 DSG3
7 skin amelanotic melanoma 10.2 DSG1 DSG3
8 dermatitis herpetiformis 10.2 DSG1 DSG3
9 physical disorder 10.2 CALCA IL6
10 acute pulmonary heart disease 10.1 DSG1 DSG3
11 pemphigus 10.1
12 classic hairy cell leukemia 10.1 DSG1 DSG3
13 blue toe syndrome 10.1 EDNRA IL6
14 hypersomnia 10.1 CALCA EDNRA
15 peripheral t-cell lymphoma 10.1 DSG1 DSG3
16 miliaria rubra 10.0
17 miliaria 10.0
18 dyskinesia of esophagus 10.0 DSG1 DSG3
19 bartholin's duct cyst 9.9 DSG1 DSG3
20 antiphospholipid syndrome 9.9 EDNRA EDNRB
21 pemphigus foliaceus 9.9
22 herpes simplex 9.9
23 herpetic whitlow 9.9 EDNRA EDNRB
24 schizoaffective disorder 9.9 CALCA IL6
25 chronic myelomonocytic leukemia 9.9 CALCA IL6
26 segmental odontomaxillary dysplasia 9.9 EDNRA EDNRB
27 central hypoventilation syndrome, congenital 9.9 CALCA EDNRB
28 hemopericardium 9.9 CALCA EDNRB
29 esophageal leukoplakia 9.8 EDNRA EDNRB
30 endometrial clear cell adenocarcinoma 9.8 EDNRB IL6
31 pseudohypoparathyroidism 9.7 DSG1 DSG3 IL6
32 hiv-1 9.7
33 toxic shock syndrome 9.7
34 dermatitis 9.7
35 atopic dermatitis 9.7
36 neonatal herpes 9.7
37 pyogenic granuloma 9.7
38 streptococcal toxic-shock syndrome 9.7
39 medullary thyroid carcinoma, familial 9.7 CALCA EDNRB
40 foodborne botulism 9.6 DSG1 EDNRB IL6
41 lethal midline granuloma 9.5 DSG1 EDNRA EDNRB
42 tuberculum sellae meningioma 9.5 EDNRB IL6
43 cervix uteri carcinoma in situ 9.2 EDNRA EDNRB
44 xanthogranulomatous pyelonephritis 9.1 EDNRA EDNRB IL6
45 juvenile dermatitis herpetiformis 9.0 CALCA DSG1 EDNRB IL6
46 lubani-al saleh-teebi syndrome 8.9 CALCA EDNRA EDNRB IL6
47 isolated scaphocephaly 7.9 CALCA DSG1 DSG3 EDNRA EDNRB IL6

Graphical network of the top 20 diseases related to Bullous Impetigo:



Diseases related to Bullous Impetigo

Symptoms & Phenotypes for Bullous Impetigo

Human phenotypes related to Bullous Impetigo:

56 32 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 septic arthritis 56 32 occasional (7.5%) Occasional (29-5%) HP:0003095
2 recurrent bacterial skin infections 56 32 hallmark (90%) Very frequent (99-80%) HP:0005406
3 abnormal blistering of the skin 56 32 hallmark (90%) Very frequent (99-80%) HP:0008066
4 erythema 56 32 hallmark (90%) Very frequent (99-80%) HP:0010783
5 abnormality of the lymphatic system 56 32 occasional (7.5%) Occasional (29-5%) HP:0100763
6 sepsis 56 32 occasional (7.5%) Occasional (29-5%) HP:0100806
7 glomerulopathy 56 32 occasional (7.5%) Occasional (29-5%) HP:0100820
8 pustule 56 32 hallmark (90%) Very frequent (99-80%) HP:0200039

MGI Mouse Phenotypes related to Bullous Impetigo:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.62 IL6 DSG3 EDNRA EDNRB
2 integument MP:0010771 9.56 IL6 DSG3 EDNRA EDNRB
3 respiratory system MP:0005388 9.46 IL6 DSG3 EDNRA EDNRB
4 skeleton MP:0005390 9.35 IL6 DSG1 DSG3 EDNRA EDNRB
5 vision/eye MP:0005391 9.02 IL6 DSG1 DSG3 EDNRA EDNRB

Drugs & Therapeutics for Bullous Impetigo

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections. Completed NCT00555061 Phase 4 Retapamulin Ointment, 1%
2 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT02090764 Phase 3 Ozenoxacin;Placebo
3 Efficacy and Safety of Ozenoxacin 1% Cream Versus Placebo in the Treatment of Patients With Impetigo Completed NCT01397461 Phase 3 ozenoxacin placebo;retapamulin 1% ointment;ozenoxacin 1% cream

Search NIH Clinical Center for Bullous Impetigo

Genetic Tests for Bullous Impetigo

Anatomical Context for Bullous Impetigo

MalaCards organs/tissues related to Bullous Impetigo:

39
Skin

Publications for Bullous Impetigo

Articles related to Bullous Impetigo:

(show top 50) (show all 54)
id Title Authors Year
1
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. ( 28329529 )
2017
2
Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy. ( 27617460 )
2016
3
Bullous Impetigo Rapid Diagnostic and Therapeutic Quiz: A Model for Assessing Basic Dermatology Knowledge of Primary Care Providers. ( 27599660 )
2016
4
Staphylococcal bullous impetigo in a neonate. ( 27458596 )
2016
5
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. ( 26603272 )
2016
6
Bullous impetigo. ( 24736928 )
2014
7
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. ( 25298068 )
2014
8
Paediatric bullous dermatoses. Linear immunoglobulin A (IgA) dermatosis. Bullous impetigo. Bullous insect bite reaction. Neonatal Herpes simplex virus (HSV) infection. ( 23111154 )
2013
9
The use of typing methods and infection prevention measures to control a bullous impetigo outbreak on a neonatal ward. ( 23168170 )
2012
10
Bullous impetigo associated with Abiotrophia defectiva in an immunocompetent adult. ( 22493280 )
2012
11
Outbreak of bullous impetigo caused by Staphylococcus aureus strains of phage type 3C/71 in a maternity ward linked to nasal carriage of a healthcare worker. ( 22378195 )
2012
12
Bullous impetigo in children infected with methicillin-resistant Staphylococcus aureus alone or in combination with methicillin-susceptible S. aureus: analysis of genetic characteristics, including assessment of exfoliative toxin gene carriage. ( 21430094 )
2011
13
Dermacase. Bullous impetigo. ( 18272632 )
2008
14
Outbreak of staphylococcal bullous impetigo in a maternity ward linked to an asymptomatic healthcare worker. ( 17945394 )
2007
15
Is blistering distal dactylitis a variant of bullous impetigo? ( 17362240 )
2007
16
Bullous impetigo: a rare presentation in fulminant streptococcal toxic shock syndrome. ( 17505275 )
2007
17
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. ( 17065642 )
2006
18
Bullous impetigo of the face after epilation by threading. ( 16172329 )
2005
19
Review: topical mupirocin or fusidic acid may be more effective than oral antibiotics for limited non-bullous impetigo. ( 15688485 )
2005
20
Treatment of bullous impetigo and the staphylococcal scalded skin syndrome in infants. ( 15482208 )
2004
21
Generalized bullous impetigo in a neonate. ( 15575854 )
2004
22
Desmosomes and disease: pemphigus and bullous impetigo. ( 15363804 )
2004
23
Confocal laser scanning microscopic observation of glycocalyx production by Staphylococcus aureus in skin lesions of bullous impetigo, atopic dermatitis and pemphigus foliaceus. ( 12653745 )
2003
24
Clinicopathological case 3: pemphigus foliaceus; bullous impetigo; subcorneal pustular dermatoses. ( 12823325 )
2003
25
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. ( 12093888 )
2002
26
Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan. ( 11992289 )
2002
27
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. ( 11062541 )
2000
28
Bullous impetigo. ( 9369884 )
1997
29
Vesicles and bulla in an infant. Bullous varicella (chicken pox complicated by bullous impetigo). ( 8285728 )
1994
30
Bullous impetigo caused by group A streptococci. A case report. ( 1350146 )
1992
31
Bullous impetigo in homosexual men--a risk marker for HIV-1 infection? ( 1607190 )
1992
32
Is penicillin still the drug of choice for non-bullous impetigo? ( 1681172 )
1991
33
Bullous impetigo and localized scalded skin syndrome in the elderly. ( 3623889 )
1987
34
Antibiotic susceptibilities of Staphylococcus aureus strains derived from furuncle and bullous impetigo. ( 3894459 )
1985
35
Vacuoles in the upper part of the epidermis as a clue to eventuation of superficial pemphigus and bullous impetigo. ( 6731731 )
1984
36
What histologic finding distinguishes superficial pemphigus and bullous impetigo? ( 6375421 )
1984
37
Effects of serum albumin on coagulase release from Staphylococcus aureus derived from bullous impetigo. ( 6386912 )
1984
38
Epidemic bullous impetigo in a nursery due to a nasal carrier of Staphylococcus aureus: role of epidemiology and control measures. ( 6376403 )
1984
39
Re-emergence of bullous impetigo. ( 6799136 )
1982
40
Sequential bullous impetigo and cutaneous Herpes simplex virus infection. ( 6761658 )
1982
41
Falsely normal direct immunofluorescent microscopic fundings in bullous impetigo. ( 7027964 )
1981
42
Re-emergence of bullous impetigo. ( 6799044 )
1981
43
Bullous impetigo caused by Streptococcus salivarius: a case report. ( 7002959 )
1980
44
The epidermolytic toxin of Staphylococcus aureus: its failure to bind to cells and its detection in blister fluids of patients with bullous impetigo. ( 701847 )
1978
45
Staphylococcal scalded skin syndrome. II. Serum level of anti exfoliatin and anti alpha-toxin in patients with staphylococcal scalded skin syndrome or bullous impetigo. ( 15461328 )
1977
46
Bullous impetigo. Occurrence of localized scalded skin syndrome in an adult. ( 782365 )
1976
47
Skin complications of heroin addiction. Bullous impetigo. ( 4513637 )
1973
48
An epidemic of bullous impetigo arising from a central admission-observation nursery. ( 5059306 )
1972
49
Bullous impetigo due to group II Staphylococcus aureus. An epidemic in a normal newborn nursery. ( 5422851 )
1970
50
Comments to "The etiology of poral closure, an experimental study of miliaria rubra, bullous impetigo and related diseases of the skin. By John P. O'Brien, M. D.". ( 15437055 )
1950

Variations for Bullous Impetigo

Expression for Bullous Impetigo

Search GEO for disease gene expression data for Bullous Impetigo.

Pathways for Bullous Impetigo

GO Terms for Bullous Impetigo

Cellular components related to Bullous Impetigo according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 DSG1 DSG3
2 desmosome GO:0030057 8.62 DSG1 DSG3

Biological processes related to Bullous Impetigo according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.58 CALCA EDNRB IL6
2 cornification GO:0070268 9.52 DSG1 DSG3
3 response to heat GO:0009408 9.51 CALCA IL6
4 monocyte chemotaxis GO:0002548 9.49 CALCA IL6
5 activation of adenylate cyclase activity GO:0007190 9.48 CALCA EDNRA
6 vasodilation GO:0042311 9.46 CALCA EDNRB
7 response to pain GO:0048265 9.43 CALCA EDNRB
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.43 CALCA EDNRA EDNRB
9 vasoconstriction GO:0042310 9.37 EDNRA EDNRB
10 negative regulation of bone resorption GO:0045779 9.32 CALCA IL6
11 enteric nervous system development GO:0048484 9.16 EDNRA EDNRB
12 regulation of blood pressure GO:0008217 9.13 CALCA EDNRA EDNRB
13 endothelin receptor signaling pathway GO:0086100 8.62 EDNRA EDNRB

Molecular functions related to Bullous Impetigo according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Bullous Impetigo

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67 TGDB
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70 UMLS via Orphanet
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