MCID: BLL012
MIFTS: 33

Bullous Impetigo malady

Skin diseases, Infectious diseases categories

Summaries for Bullous Impetigo

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63Wikipedia, 32MalaCards
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Wikipedia:63 Bullous Impetigo is a cutaneous condition that characteristically occurs in the newborn, and is caused... more...

MalaCards: Bullous Impetigo is related to impetigo and pemphigus, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, erythema/erythematous lesions/erythroderma/polymorphous erythema and vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment. An important gene associated with Bullous Impetigo is DSG1 (desmoglein 1), and among its related pathways are Apoptotic cleavage of cellular proteins and Apoptotic cleavage of cell adhesion proteins. The compounds ivig and [125i]et-1 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype craniofacial.

Aliases & Classifications for Bullous Impetigo

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
bullous impetigo:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

bullous impetigo 48 60


External Ids:

ICD10 via Orphanet26 L01.0
SNOMED-CT via Orphanet57 399183005
UMLS via Orphanet61 C0021100

Related Diseases for Bullous Impetigo

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bullous Impetigo:



Diseases related to bullous impetigo

Clinical Features for Bullous Impetigo

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48Orphanet
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Symptoms:

48 (show all 7)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • renal glomerular defect/glomerulopathy
  • anomalies of the lymphatic system
  • sepsis severe/septicemia
  • pustula/pustulosis

Drugs & Therapeutics for Bullous Impetigo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bullous Impetigo

Drug clinical trials:

Search ClinicalTrials for Bullous Impetigo

Search NIH Clinical Center for Bullous Impetigo

Search CenterWatch for Bullous Impetigo

Genetic Tests for Bullous Impetigo

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Anatomical Context for Bullous Impetigo

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32MalaCards
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MalaCards organs/tissues related to Bullous Impetigo:

32
Skin

Animal Models for Bullous Impetigo or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bullous Impetigo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5DSG3, EDNRA, EDNRB

Publications for Bullous Impetigo

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Genetic Variations for Bullous Impetigo

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Expression for genes affiliated with Bullous Impetigo

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bullous Impetigo

Search GEO for disease gene expression data for Bullous Impetigo.

Pathways for genes affiliated with Bullous Impetigo

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Bullous Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4DSG3, DSG1
29.4DSG1, DSG3
3
Hide members
9.0EDNRA, EDNRB
49.0EDNRA, EDNRB
59.0EDNRA, EDNRB
69.0EDNRA, EDNRB

Compounds for genes affiliated with Bullous Impetigo

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Bullous Impetigo according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1ivig449.5DSG1, DSG3
2[125i]et-1289.4EDNRB, EDNRA
3sitaxsentan44 2810.4EDNRA, EDNRB
4pd 145065449.4EDNRA, EDNRB
5pd 142893449.4EDNRB, EDNRA
6bq610449.4EDNRB, EDNRA
7bq 302044 2810.4EDNRB, EDNRA
8ambrisentan44 2810.4EDNRB, EDNRA
9irl 162044 2810.4EDNRA, EDNRB
10tezosentan449.4EDNRA, EDNRB
11Sitaxentan119.3EDNRA, EDNRB
12fr13931744 2810.3EDNRB, EDNRA
13darusentan44 2810.3EDNRA, EDNRB
14atrasentan449.3EDNRA, EDNRB
15sarafotoxin449.3EDNRA, EDNRB
16bq78844 2810.3EDNRA, EDNRB
17bq12344 2810.3EDNRB, EDNRA
18bosentan44 1110.3EDNRA, EDNRB
19sulfonamide449.2EDNRA, EDNRB
20phosphoramidon44 1110.2EDNRA, EDNRB
21losartan44 49 28 1112.0EDNRB, EDNRA
22prednisolone44 28 1111.0DSG3, EDNRA
23prostacyclin449.0EDNRA, EDNRB
24agarose448.7EDNRA, EDNRB
25toxin a448.4DSG1, DSG3, EDNRA, EDNRB
26acetylcholine44 49 28 11 2412.4DSG1, DSG3, EDNRA, EDNRB
27serine448.1EDNRB, EDNRA, DSG3, DSG1
28calcium44 49 11 2411.1DSG1, DSG3, EDNRA, EDNRB

GO Terms for genes affiliated with Bullous Impetigo

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16Gene Ontology
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Cellular components related to Bullous Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.3DSG1, DSG3
2nuclear membraneGO:0319658.7EDNRA, EDNRB
3plasma membraneGO:0058868.0DSG1, DSG3, EDNRA, EDNRB

Biological processes related to Bullous Impetigo according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in execution phase of apoptosisGO:0069219.5DSG1, DSG3
2homophilic cell adhesionGO:0071569.4DSG1, DSG3
3regulation of epithelial cell proliferationGO:0506789.3EDNRA, EDNRB
4vasoconstrictionGO:0423109.2EDNRA, EDNRB
5enteric nervous system developmentGO:0484849.2EDNRB, EDNRA
6sensory perception of painGO:0192339.2EDNRA, EDNRB
7regulation of blood pressureGO:0082179.1EDNRB, EDNRA
8positive regulation of protein phosphorylationGO:0019349.0EDNRA, EDNRB
9agingGO:0075688.9EDNRA, EDNRB
10elevation of cytosolic calcium ion concentrationGO:0072048.7EDNRA, EDNRB

Molecular functions related to Bullous Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:0049629.0EDNRA, EDNRB

Products for genes affiliated with Bullous Impetigo

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bullous Impetigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet