MCID: BLL012
MIFTS: 33

Bullous Impetigo malady

Skin diseases, Infectious diseases categories

Summaries for Bullous Impetigo

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63Wikipedia, 32MalaCards
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Wikipedia:63 Bullous Impetigo is a cutaneous condition that characteristically occurs in the newborn, and is caused... more...

MalaCards: Bullous Impetigo is related to impetigo and pemphigus, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, erythema/erythematous lesions/erythroderma/polymorphous erythema and vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment. An important gene associated with Bullous Impetigo is DSG1 (desmoglein 1), and among its related pathways are Apoptotic cleavage of cellular proteins and Apoptotic cleavage of cell adhesion proteins. The compounds ivig and [125i]et-1 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype craniofacial.

Aliases & Classifications for Bullous Impetigo

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
bullous impetigo:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

bullous impetigo 48 60


External Ids:

ICD10 via Orphanet26 L01.0
SNOMED-CT via Orphanet57 399183005
UMLS via Orphanet61 C0021100

Related Diseases for Bullous Impetigo

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bullous Impetigo:



Diseases related to bullous impetigo

Clinical Features for Bullous Impetigo

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48Orphanet
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Symptoms:

48 (show all 7)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • renal glomerular defect/glomerulopathy
  • anomalies of the lymphatic system
  • sepsis severe/septicemia
  • pustula/pustulosis

Drugs & Therapeutics for Bullous Impetigo

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bullous Impetigo

Drug clinical trials:

Search ClinicalTrials for Bullous Impetigo

Search NIH Clinical Center for Bullous Impetigo

Search CenterWatch for Bullous Impetigo

Genetic Tests for Bullous Impetigo

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Anatomical Context for Bullous Impetigo

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32MalaCards
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MalaCards organs/tissues related to Bullous Impetigo:

32
Skin

Animal Models for Bullous Impetigo or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bullous Impetigo:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.5DSG3, EDNRA, EDNRB

Publications for Bullous Impetigo

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Genetic Variations for Bullous Impetigo

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Expression for genes affiliated with Bullous Impetigo

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bullous Impetigo

Search GEO for disease gene expression data for Bullous Impetigo.

Pathways for genes affiliated with Bullous Impetigo

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Bullous Impetigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4DSG1, DSG3
29.4DSG3, DSG1
3
Hide members
9.0EDNRB, EDNRA
49.0EDNRB, EDNRA
59.0EDNRA, EDNRB
69.0EDNRB, EDNRA

Compounds for genes affiliated with Bullous Impetigo

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Bullous Impetigo according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1ivig449.5DSG3, DSG1
2[125i]et-1289.4EDNRA, EDNRB
3pd 145065449.4EDNRA, EDNRB
4sitaxsentan44 2810.4EDNRA, EDNRB
5ambrisentan44 2810.4EDNRB, EDNRA
6pd 142893449.4EDNRB, EDNRA
7bq 302044 2810.4EDNRA, EDNRB
8bq610449.4EDNRA, EDNRB
9atrasentan449.4EDNRB, EDNRA
10sarafotoxin449.4EDNRA, EDNRB
11fr13931744 2810.3EDNRA, EDNRB
12irl 162044 2810.3EDNRA, EDNRB
13Sitaxentan119.3EDNRB, EDNRA
14tezosentan449.3EDNRA, EDNRB
15darusentan44 2810.3EDNRB, EDNRA
16bq78844 2810.3EDNRA, EDNRB
17bq12344 2810.3EDNRB, EDNRA
18bosentan44 1110.3EDNRB, EDNRA
19sulfonamide449.2EDNRA, EDNRB
20phosphoramidon44 1110.2EDNRB, EDNRA
21losartan44 49 28 1112.0EDNRB, EDNRA
22prednisolone44 28 1111.0EDNRA, DSG3
23prostacyclin449.0EDNRA, EDNRB
24agarose448.7EDNRA, EDNRB
25toxin a448.4EDNRB, DSG1, DSG3, EDNRA
26acetylcholine44 49 28 11 2412.4EDNRB, EDNRA, DSG3, DSG1
27serine448.1DSG3, EDNRA, EDNRB, DSG1
28calcium44 49 11 2411.1DSG1, DSG3, EDNRA, EDNRB

GO Terms for genes affiliated with Bullous Impetigo

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16Gene Ontology
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Cellular components related to Bullous Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.3DSG1, DSG3
2nuclear membraneGO:0319658.7EDNRA, EDNRB
3plasma membraneGO:0058868.0DSG1, DSG3, EDNRA, EDNRB

Biological processes related to Bullous Impetigo according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in execution phase of apoptosisGO:0069219.5DSG3, DSG1
2homophilic cell adhesionGO:0071569.4DSG3, DSG1
3regulation of epithelial cell proliferationGO:0506789.3EDNRB, EDNRA
4vasoconstrictionGO:0423109.2EDNRA, EDNRB
5enteric nervous system developmentGO:0484849.2EDNRA, EDNRB
6sensory perception of painGO:0192339.2EDNRB, EDNRA
7regulation of blood pressureGO:0082179.1EDNRB, EDNRA
8positive regulation of protein phosphorylationGO:0019349.0EDNRB, EDNRA
9agingGO:0075688.9EDNRB, EDNRA
10elevation of cytosolic calcium ion concentrationGO:0072048.7EDNRB, EDNRA

Molecular functions related to Bullous Impetigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:0049629.0EDNRA, EDNRB

Products for genes affiliated with Bullous Impetigo

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bullous Impetigo

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet