MCID: BLL004
MIFTS: 43

Bullous Keratopathy malady

Eye diseases category
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Summaries for Bullous Keratopathy

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Wikipedia:65 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

MalaCards based summary: Bullous Keratopathy is related to keratoconus and corneal disease. An important gene associated with Bullous Keratopathy is TNC (tenascin C), and among its related pathways are Angiogenesis and ECM proteoglycans. The compounds procollagen and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Bullous Keratopathy

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Bullous Keratopathy, Aliases & Descriptions:

Name: Bullous Keratopathy 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:11031
ICD9CM27 371.23
SNOMED-CT57 193815002, 57207003
NCIt39 C26970
ICD1025 H18.1

Related Diseases for Bullous Keratopathy

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Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to bullous keratopathy

Symptoms for Bullous Keratopathy

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Drugs & Therapeutics for Bullous Keratopathy

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Drug clinical trials:

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Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

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Anatomical Context for Bullous Keratopathy

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MalaCards organs/tissues related to Bullous Keratopathy:

32
Endothelial, Eye, Testes

Animal Models for Bullous Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Bullous Keratopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0IL1A, SOD3, TGFB2, FBN1
2MP:00053767.2IL1A, SOD3, TGFB2, TNC, FBN1

Publications for Bullous Keratopathy

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Articles related to Bullous Keratopathy:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
2
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
3
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
4
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
5
Comparison of treatments for bullous keratopathy in rabbits. (23737903)
2013
6
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. (23861578)
2013
7
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. (23957427)
2013
8
Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty. (22153314)
2012
9
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012
10
Rationale for performing penetrating keratoplasty rather than DSAEK in patients with bullous keratopathy in Japan. (22869384)
2012
11
Descemetorrhexis in endothelial keratoplasty to avoid peripheral bullous keratopathy. (22687300)
2012
12
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. (22467587)
2012
13
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
14
Corneal nerve aberrations in bullous keratopathy. (21310389)
2011
15
Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy. (21866044)
2011
16
Sutureless amniotic membrane fixation with fibrin glue in symptomatic bullous keratopathy with poor visual potential. (20047183)
2010
17
Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. (20142847)
2010
18
A chandelier-illuminated anterior chamber maintainer for use during descemet stripping automated endothelial keratoplasty in patients with advanced bullous keratopathy. (20508515)
2010
19
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
20
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
21
Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. (16848159)
2006
22
Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. (16186344)
2005
23
Recurrence of giant pseudocyst in advanced bullous keratopathy. (14976545)
2004
24
Long-term follow-up for bullous keratopathy after sato-type anterior-posterior corneal refractive surgery. (14644229)
2003
25
Response to symptomatic management of postoperative bullous keratopathy with nonpreserved human amniotic membrane. (12605061)
2003
26
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
27
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. (11668187)
2001
28
Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. (11446768)
2001
29
Ophthaproblem. Pseudophakic bullous keratopathy. (10907565)
2000
30
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma. (9493117)
1998
31
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)
1995
32
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
33
Proteoglycan distribution in the corneas of individuals with bullous keratopathy. (2083765)
1990
34
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
35
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
36
The bandage lens in bullous keratopathy. (2594381)
1989
37
Penetrating keratoplasty for pseudophakic bullous keratopathy. Management of the intraocular lens. (3062537)
1988
38
Intraocular lens removal during penetrating keratoplasty for pseudophakic bullous keratopathy. (3299201)
1987
39
Results of penetrating keratoplasty for aphakic bullous keratopathy. (3155046)
1986
40
Pseudophakic bullous keratopathy: relationship with endothelial cell density and use of a predictive cell loss model. A preliminary report. (3720342)
1986
41
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
42
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
43
Bullous keratopathy: a perspective on the American experience. (6478579)
1984
44
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. (7081358)
1982
45
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
46
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977
47
Histopathologic findings in corneas following lens extraction and results of keratoplasty for aphakic bullous keratopathy. (4940981)
1971
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Clinical observations on the treatment of bullous keratopathy. (13556833)
1957-1958
50
Studies on the clinical physiology of the cornea; the interrelationship of corneal turgescence, epithelial edema, bullous keratopathy, and interstitial vascularization. (18121090)
1949

Variations for Bullous Keratopathy

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Expression for genes affiliated with Bullous Keratopathy

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Expression patterns in normal tissues for genes affiliated with Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for genes affiliated with Bullous Keratopathy

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Compounds for genes affiliated with Bullous Keratopathy

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Compounds related to Bullous Keratopathy according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1procollagen449.8TNC, IL1A
2manganese superoxide449.8IL1A, SOD3
3neopterin449.7IL1A, TGFB2
4p003449.7TGFB2, TNC
5uric acid44 2410.6TGFB2, SOD3
6formaldehyde44 2410.6IL1A, TNC
71,25 dihydroxy vitamin d3449.6TGFB2, IL1A
8hydrocortisone44 2 61 1112.5TGFB2, IL1A
9chondroitin sulfate44 2410.5FBN1, TNC
10egcg449.5TGFB2, IL1A
11sodium dodecylsulfate449.4FBN1, IL1A
12homocysteine44 2410.3FBN1, SOD3
13prostaglandin449.3TGFB2, IL1A
14h2o2449.3TNC, IL1A, SOD3
15glycosaminoglycan449.3TNC, IL1A, TGFB2
16calcitriol44 61 24 1112.2IL1A, TGFB2
17creatinine449.2TGFB2, IL1A, TNC
18cycloheximide449.2IL1A, TGFB2, TNC
19dexamethasone44 50 28 1112.2TNC, TGFB2, IL1A
20nitric oxide44 24 1111.1IL1A, SOD3, TGFB2
21heparan sulfate44 2410.1SOD3, TNC, FBN1
22vitamin a44 24 1111.0TGFB2, IL1A
23tgf beta1449.0FBN1, TNC, TGFB2
24arginine448.9IL1A, SOD3, FBN1
25vegf448.7IL1A, TGFB2, SOD3, TNC
26estrogen448.7TGFB2, FBN1, TNC
27lipid448.7FBN1, TNC, SOD3
28hyaluronic acid44 249.5FBN1, TGFB2, TNC, IL1A
29progesterone44 28 61 24 1112.4IL1A, TGFB2, TNC, FBN1
30glutamate448.4FBN1, TNC, TGFB2, IL1A
31retinoic acid44 249.4FBN1, IL1A, TNC, TGFB2
32cysteine448.4TNC, FBN1, TGFB2, SOD3
33vitamin d448.4SOD3, IL1A, TGFB2, FBN1
34ascorbic acid44 248.9IL1A, FBN1, TNC, TGFB2, SOD3
35heparin44 28 24 1110.9IL1A, FBN1, TNC, SOD3, TGFB2
36serine447.9IL1A, SOD3, TGFB2, TNC, FBN1

GO Terms for genes affiliated with Bullous Keratopathy

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Cellular components related to Bullous Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.2FBN1, TNC
2extracellular matrixGO:0310128.1FBN1, TNC, TGFB2, SOD3
3extracellular spaceGO:0056157.4FBN1, TNC, TGFB2, SOD3, IL1A
4extracellular regionGO:0055767.2FBN1, TNC, TGFB2, SOD3, IL1A

Biological processes related to Bullous Keratopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:0466889.6SOD3, IL1A
2response to woundingGO:0096119.5TNC, TGFB2
3positive regulation of cell divisionGO:0517819.4IL1A, TGFB2
4wound healingGO:0420609.4TNC, TGFB2
5response to hypoxiaGO:0016669.3TGFB2, SOD3
6positive regulation of gene expressionGO:0106289.3TNC, TGFB2
7heart developmentGO:0075078.7FBN1, TGFB2
8extracellular matrix organizationGO:0301988.7TGFB2, FBN1, TNC

Molecular functions related to Bullous Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3IL1A, TGFB2
2copper ion bindingGO:0055079.1IL1A, SOD3

Products for genes affiliated with Bullous Keratopathy

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Sources for Bullous Keratopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet