MCID: BLL004
MIFTS: 44

Bullous Keratopathy malady

Category: Eye diseases

Aliases & Classifications for Bullous Keratopathy

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Aliases & Descriptions for Bullous Keratopathy:

Name: Bullous Keratopathy 11 49 13 67

Classifications:



External Ids:

Disease Ontology11 DOID:11031
ICD1029 H18.1
SNOMED-CT61 193815002, 57207003
ICD9CM31 371.23
NCIt44 C26970

Summaries for Bullous Keratopathy

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Wikipedia:70 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

MalaCards based summary: Bullous Keratopathy is related to keratopathy and endotheliitis, and has symptoms including eye swelling An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Related Diseases for Bullous Keratopathy

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Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1keratopathy10.9
2endotheliitis10.5
3acromicric dysplasia10.5FBN1, TGFB2
4tgfbr1-related loeys-dietz syndrome10.3TGFB2, TGFB3
5loeys-dietz syndrome 410.3TGFB2, TGFB3
6renal clear cell carcinoma10.3TGFB2, TGFB3
7adenosine monophosphate deaminase deficiency erythrocyte type10.3TGFB2, TGFB3
8humeroradial synostosis10.3BMP2, BMP4
9strawberry gallbladder10.3TGFB2, TGFB3
10brain stem angioblastoma10.2FBN1, IL1A, TNC
11twin-to-twin transfusion syndrome10.2TGFB2, TGFB3
12cataract10.2
13short qt syndrome10.1BMP2, BMP4
14colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.1BMP2, BMP4
15cervical benign neoplasm10.1BMP2, BMP4
16brucella canis brucellosis10.1FBN1, TGFB2
17keratitis10.1
18fuchs' endothelial dystrophy10.1
19descending colon cancer10.1BMP2, BMP4
20herpetic gastritis10.0FBN1, TGFB2, TGFB3
21inhalation anthrax10.0CXCL8, TNC
22epidemic typhus10.0FBN1, TGFB2, TGFB3
23omphalocele10.0BMP2, IL1A
24gasserian ganglion meningioma10.0CXCL8, TGFB2
25keratoconus9.9
26corneal disease9.9
27pulmonary valve insufficiency9.9CXCL8, IL1A
28uterus carcinoma in situ9.9CXCL8, IL1A
29orbital lymphangioma9.9CXCL8, IL1A
30pseudoretinitis pigmentosa9.9CXCL8, IL1A
31syphilitic myelopathy9.9BMP2, BMP4, TGFB3
3246 xy gonadal dysgenesis9.9AQP3, TGFB2, TGFB3
33astigmatism9.9
34herpes simplex9.9
35aniridia9.7
36insulin-like growth factor i9.7
37acne9.7
38corneal endothelial dystrophy9.7
39open-angle glaucoma9.7
40corneal edema9.7
41myopia9.7
42corneal ulcer9.7
43refractive error9.7
44essential iris atrophy9.7
459.7CXCL8, IL1A
46diamond-blackfan anemia 39.7CXCL8, IL1A, TNC
47pleomorphic lipoma9.6BMP2, CXCL8, IL1A
48accessory nerve disease9.4CXCL8, IL1A
49leukemia9.4BMP4, FBN1, NID1, TGFB2, TNC
50idiopathic corneal edema7.5AQP3, BMP2, BMP4, FBN1, IL1A, MIP

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal EdemaCorneal Degeneration
Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to bullous keratopathy

Symptoms for Bullous Keratopathy

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UMLS symptoms related to Bullous Keratopathy:


eye swelling

Drugs & Therapeutics for Bullous Keratopathy

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Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylprednisoloneapproved, vet_approvedPhase 2115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
Prednisoloneapproved, vet_approvedPhase 2115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
FluorometholoneapprovedPhase 219426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
 
Fluorometholone (JP15/USP/INN)
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml (TN)
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
4
Bevacizumabapproved, investigationalPhase 21968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
5Pharmaceutical SolutionsPhase 27793
6Peripheral Nervous System AgentsPhase 222776
7Methylprednisolone HemisuccinatePhase 21153
8Neuroprotective AgentsPhase 21672
9Protective AgentsPhase 27190
10Prednisolone hemisuccinatePhase 21153
11Prednisolone acetatePhase 21153
12Methylprednisolone acetatePhase 21153
13AnestheticsPhase 29001
14Prednisolone phosphatePhase 21153
15Anti-Inflammatory AgentsPhase 210355
16AntiemeticsPhase 23888
17Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
18Anti-Allergic AgentsPhase 21490
19Antineoplastic Agents, HormonalPhase 25407
20Autonomic AgentsPhase 29774
21HormonesPhase 213979
22Hormone AntagonistsPhase 212778
23glucocorticoidsPhase 24920
24Gastrointestinal AgentsPhase 28109
25MitogensPhase 21526
26Endothelial Growth FactorsPhase 2362
27Angiogenesis Modulating AgentsPhase 24072
28Angiogenesis InhibitorsPhase 24143
29
Folic Acidapproved, nutraceutical, vet_approved427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
30
Riboflavinapproved, nutraceutical, vet_approved16583-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
31Anti-Bacterial Agents10884
32Alkylating Agents4694
33Mitomycins233
34Nucleic Acid Synthesis Inhibitors4855
35Vitamins5095
36Antibiotics, Antitubercular6972
37Dermatologic Agents5674
38Micronutrients5802
39Photosensitizing Agents476
40Trace Elements5802
41Vitamin B Complex4229
42FolateNutraceutical4279
43Vitamin B2Nutraceutical165
44Vitamin B9Nutraceutical4279

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Amniotic Membrane Graft In Syntomathic Bullous KeratopathyCompletedNCT01926535Phase 2
2Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)CompletedNCT01448213Phase 2
3Pain and Visual Outcome in Intravitreal Bevacizumab InjectionEnrolling by invitationNCT02790775Phase 2
4Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture MediaUnknown statusNCT00623584
5Comparing Endoglide to Endoserter for DSAEK Graft InsertionUnknown statusNCT01791075
6Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal EdemaUnknown statusNCT01890252
7Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Unknown statusNCT02020044
8Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous KeratopathyCompletedNCT00659308
9The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous KeratopathyCompletedNCT01106274
10Automated Lamellar Keratectomy in Symptomatic Patients With Bullous KeratopathyCompletedNCT00654888
11The SNEC DSAEK EndoGlide Clinical TrialCompletedNCT01122043
12Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal EdemaRecruitingNCT02660151
13Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
14Corneal Transplantation Guided by OCT RESCANNot yet recruitingNCT02736877
15Topical Steroid Treatment After Posterior Lamellar Corneal TransplantationWithdrawnNCT01682421

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

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Anatomical Context for Bullous Keratopathy

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MalaCards organs/tissues related to Bullous Keratopathy:

35
Endothelial, Eye, Testes

Animal Models for Bullous Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Bullous Keratopathy:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.3AQP3, BMP2, BMP4, TGFB2, TNC
2MP:00053719.2BMP2, BMP4, FBN1, TGFB2, TGFB3
3MP:00053828.8AQP3, BMP2, BMP4, FBN1, TGFB2, TGFB3
4MP:00053908.7AQP3, BMP2, BMP4, FBN1, TGFB2, TGFB3
5MP:00053768.1AQP3, BMP2, BMP4, FBN1, IL1A, TGFB2
6MP:00053857.8AQP3, BMP2, BMP4, FBN1, IL1A, NID1
7MP:00053917.7AQP3, BMP4, MIP, NID1, TGFB2, TGFB3

Publications for Bullous Keratopathy

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Articles related to Bullous Keratopathy:

(show top 50)    (show all 254)
idTitleAuthorsYear
1
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. (27820951)
2016
2
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. (27994806)
2016
3
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. (26509766)
2015
4
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. (26491241)
2015
5
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). (25959108)
2015
6
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. (25627186)
2014
7
Femtosecond laser-assisted intracorneal biopolymer insertion for the symptomatic treatment of bullous keratopathy. (24619170)
2014
8
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
9
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
10
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. (23861578)
2013
11
Descemet stripping automated endothelial keratoplasty for bullous keratopathy with an irregular posterior surface. (23846407)
2013
12
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012
13
Descemetorrhexis in endothelial keratoplasty to avoid peripheral bullous keratopathy. (22687300)
2012
14
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. (22467587)
2012
15
In vivo confocal microscopic and histological findings of unknown bullous keratopathy probably associated with pseudoexfoliation syndrome. (22727450)
2012
16
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
17
Corneal nerve aberrations in bullous keratopathy. (21310389)
2011
18
Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy. (21866044)
2011
19
A 10.0-mm posterior lamellar graft for bullous keratopathy in a buphthalmic eye. (20595891)
2010
20
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
21
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
22
Combined phototherapeutic keratectomy and amniotic membrane grafts for symptomatic bullous keratopathy. (19724207)
2009
23
Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: laboratory investigation and first clinical case. (18811120)
2008
24
Amniotic membrane transplantation with anterior stromal micropuncture for treatment of painful bullous keratopathy in eyes with poor visual potential. (17251820)
2007
25
Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. (16848159)
2006
26
Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. (16186344)
2005
27
Bullous keratopathy treated with honey. (15799749)
2005
28
Long-term follow-up for bullous keratopathy after sato-type anterior-posterior corneal refractive surgery. (14644229)
2003
29
Response to symptomatic management of postoperative bullous keratopathy with nonpreserved human amniotic membrane. (12605061)
2003
30
Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. (14550395)
2003
31
Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. (11446768)
2001
32
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)
1995
33
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
34
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
35
The bandage lens in bullous keratopathy. (2594381)
1989
36
Penetrating keratoplasty for pseudophakic bullous keratopathy. Management of the intraocular lens. (3062537)
1988
37
Bullous keratopathy: a study of endothelial cell morphology in patients undergoing cataract surgery. (3390413)
1988
38
Penetrating keratoplasty for pseudophakic bullous keratopathy after extracapsular cataract extraction. (3282436)
1988
39
Pseudophakic bullous keratopathy: relationship with endothelial cell density and use of a predictive cell loss model. A preliminary report. (3720342)
1986
40
Penetrating keratoplasty in aphakic bullous keratopathy. (3155047)
1986
41
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
42
Specular microscopic follow-up of corneal grafts for pseudophakic bullous keratopathy. (3887265)
1985
43
Bullous keratopathy: a perspective on the American experience. (6478579)
1984
44
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. (7081358)
1982
45
The ultrastructure of Descemet's membrane. II. Aphakic bullous keratopathy. (7150062)
1982
46
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977
47
Incidence of bullous keratopathy. (1230273)
1975
48
Histopathologic findings in corneas following lens extraction and results of keratoplasty for aphakic bullous keratopathy. (4940981)
1971
49
Clinical observations on the treatment of bullous keratopathy. (13556833)
1957-1958
50
Studies on the clinical physiology of the cornea; the interrelationship of corneal turgescence, epithelial edema, bullous keratopathy, and interstitial vascularization. (18121090)
1949

Variations for Bullous Keratopathy

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Expression for genes affiliated with Bullous Keratopathy

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Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for genes affiliated with Bullous Keratopathy

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Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathwaysScoreTop Affiliating Genes
19.6TGFB2, TGFB3
29.6TGFB2, TGFB3
39.6BMP2, BMP4
4
Show member pathways
9.3TGFB2, TGFB3, TNC
59.3TGFB2, TGFB3, TNC
69.3IL1A, TGFB2, TGFB3
7
Show member pathways
9.3IL1A, TGFB2, TGFB3
89.2BMP4, TGFB2, TGFB3
98.9BMP2, CXCL8, IL1A
108.8CXCL8, TGFB2, TGFB3
118.8CXCL8, TGFB2, TGFB3
128.8BMP2, BMP4, TGFB2, TGFB3
13
Show member pathways
8.8BMP2, BMP4, TGFB2, TGFB3
148.8BMP2, BMP4, TGFB2, TGFB3
158.8BMP2, BMP4, TGFB2, TGFB3
168.8BMP2, BMP4, TGFB2, TGFB3
17
Show member pathways
8.5BMP2, BMP4, FBN1, TGFB2, TGFB3
188.5CXCL8, IL1A, TGFB2, TGFB3
198.5CXCL8, IL1A, TGFB2, TGFB3
20
Show member pathways
8.4BMP2, BMP4, IL1A, TGFB2, TGFB3
21
Show member pathways
8.2AQP3, BMP2, BMP4, TGFB2, TGFB3
22
Show member pathways
8.2BMP2, BMP4, FBN1, TGFB2, TGFB3, TNC
237.9BMP2, BMP4, CXCL8, TGFB2, TGFB3
247.9BMP2, BMP4, CXCL8, IL1A, TGFB3
25
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
26
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
27
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
28
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
29
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
30
Show member pathways
7.6BMP2, BMP4, FBN1, NID1, TGFB2, TGFB3
31
Show member pathways
7.0BMP2, BMP4, CXCL8, FBN1, IL1A, TGFB2

GO Terms for genes affiliated with Bullous Keratopathy

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Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.8FBN1, NID1, TNC
2proteinaceous extracellular matrixGO:00055789.0BMP4, FBN1, NID1, TNC
3extracellular matrixGO:00310128.6FBN1, NID1, TGFB2, TGFB3, TNC
4extracellular spaceGO:00056157.0BMP2, BMP4, CXCL8, FBN1, IL1A, TGFB2
5extracellular regionGO:00055766.1BMP2, BMP4, CXCL8, FBN1, IL1A, NID1

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:004866310.4BMP4, TGFB2
2cardiac right ventricle morphogenesisGO:000321510.4BMP4, TGFB2
3outflow tract septum morphogenesisGO:000314810.4BMP4, TGFB2
4membranous septum morphogenesisGO:000314910.4BMP4, TGFB2
5pulmonary valve morphogenesisGO:000318410.4BMP4, TGFB2
6pharyngeal arch artery morphogenesisGO:006162610.4BMP4, TGFB2
7endocardial cushion morphogenesisGO:000320310.3BMP2, TGFB2
8pathway-restricted SMAD protein phosphorylationGO:006038910.3BMP2, TGFB2
9cardiac epithelial to mesenchymal transitionGO:006031710.3BMP2, TGFB2
10uterine wall breakdownGO:004270410.3TGFB2, TGFB3
11glycerol transportGO:001579310.3AQP3, MIP
12cellular water homeostasisGO:000999210.3AQP3, MIP
13SMAD protein import into nucleusGO:000718410.3TGFB2, TGFB3
14metanephros developmentGO:000165610.3BMP4, FBN1
15salivary gland morphogenesisGO:000743510.3TGFB2, TGFB3
16mesenchymal cell proliferation involved in ureteric bud developmentGO:007213810.2BMP2, BMP4
17positive regulation of pri-miRNA transcription from RNA polymerase II promoterGO:190289510.2BMP2, BMP4
18BMP signaling pathway involved in heart inductionGO:000313010.2BMP2, BMP4
19telencephalon regionalizationGO:002197810.2BMP2, BMP4
20water transportGO:000683310.2AQP3, MIP
21cardiac muscle cell differentiationGO:005500710.2BMP2, BMP4
22telencephalon developmentGO:002153710.2BMP2, BMP4
23atrioventricular valve morphogenesisGO:000318110.2BMP2, TGFB2
24epithelial to mesenchymal transitionGO:000183710.2BMP2, TGFB2
25negative regulation of macrophage cytokine productionGO:001093610.2TGFB2, TGFB3
26cell-cell junction organizationGO:004521610.2TGFB2, TGFB3
27positive regulation of cartilage developmentGO:006103610.1BMP2, BMP4
28positive regulation of collagen biosynthetic processGO:003296710.1BMP4, TGFB3
29positive regulation of SMAD protein import into nucleusGO:006039110.1BMP4, TGFB3
30face morphogenesisGO:006032510.0TGFB2, TGFB3
31regulation of odontogenesis of dentin-containing toothGO:004248710.0BMP2, BMP4
32positive regulation of ossificationGO:00457789.9BMP2, BMP4, TGFB2
33positive regulation of cell divisionGO:00517819.8IL1A, TGFB2, TGFB3
34embryonic digestive tract developmentGO:00485669.8CXCL8, TGFB2
35odontogenesis of dentin-containing toothGO:00424759.8BMP2, BMP4, TNC
36positive regulation of bone mineralizationGO:00305019.7BMP2, BMP4, TGFB3
37positive regulation of epithelial to mesenchymal transitionGO:00107189.7BMP2, TGFB2, TGFB3
38positive regulation of protein secretionGO:00507149.6IL1A, TGFB2, TGFB3
39osteoblast differentiationGO:00016499.6BMP2, BMP4, TNC
40negative regulation of gene expressionGO:00106299.6BMP2, BMP4, TGFB2
41SMAD protein signal transductionGO:00603959.4BMP2, BMP4, TGFB2, TGFB3
42skeletal system developmentGO:00015019.3BMP2, BMP4, FBN1, TGFB2
43positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.3BMP2, BMP4, TGFB2, TGFB3
44odontogenesisGO:00424769.3AQP3, BMP4, TGFB2, TGFB3
45response to hypoxiaGO:00016669.2BMP2, TGFB2, TGFB3
46wound healingGO:00420609.1BMP4, TGFB2, TGFB3, TNC
47heart developmentGO:00075079.1BMP2, BMP4, FBN1, TGFB2
48extracellular matrix organizationGO:00301989.1FBN1, NID1, TGFB2, TNC
49positive regulation of gene expressionGO:00106288.6BMP2, BMP4, IL1A, TGFB2, TNC
50negative regulation of cell proliferationGO:00082857.3BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1type III transforming growth factor beta receptor bindingGO:003471410.2TGFB2, TGFB3
2type II transforming growth factor beta receptor bindingGO:000511410.2TGFB2, TGFB3
3glycerol channel activityGO:001525410.2AQP3, MIP
4water channel activityGO:001525010.2AQP3, MIP
5BMP receptor bindingGO:007070010.1BMP2, BMP4
6transforming growth factor beta receptor bindingGO:00051609.8BMP2, BMP4, TGFB2
7co-receptor bindingGO:00397069.6BMP2, BMP4
8growth factor activityGO:00080838.7BMP2, BMP4, TGFB2, TGFB3
9cytokine activityGO:00051258.4BMP2, BMP4, IL1A, TGFB2, TGFB3

Sources for Bullous Keratopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet