Aliases & Classifications for Bullous Keratopathy

Aliases & Descriptions for Bullous Keratopathy:

Name: Bullous Keratopathy 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD10 33 H18.1
ICD9CM 35 371.23
NCIt 47 C26970
SNOMED-CT 64 193815002 57207003
UMLS 69 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to keratopathy and endotheliitis, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Fluorometholone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related phenotypes are cardiovascular system and craniofacial

Wikipedia : 71 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 keratopathy 10.9
2 endotheliitis 10.5
3 geleophysic dysplasia 2 10.2 FBN1 TGFB2
4 thalassemia minor 10.2 TGFB2 TGFB3
5 cataract 10.2
6 legionaire disease 10.1 TGFB2 TGFB3
7 juvenile onset parkinson disease 19a 10.1 BMP2 BMP4
8 intellectual developmental disorder with persistence of fetal hemoglobin 10.1 TGFB2 TGFB3
9 renal tubular transport disease 10.1 TGFB2 TGFB3
10 tarsal-carpal coalition syndrome 10.1 BMP2 BMP4
11 multiple synostoses syndrome 10.1 BMP2 BMP4
12 salt and pepper syndrome 10.1 BMP2 BMP4
13 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.1 BMP2 FBN1 TNC
14 discharging ear 10.1 TGFB2 TGFB3
15 keratitis 10.0
16 fuchs' endothelial dystrophy 10.0
17 leber congenital amaurosis 10.0 TGFB3 TNC
18 endemic typhus 10.0 FBN1 TGFB2 TGFB3
19 tmem231-related meckel syndrome 10.0 FBN1 TGFB2 TGFB3
20 microglandular adenosis of breast 10.0 CXCL8 IL1A
21 autoimmune polyendocrine syndrome type 1 10.0 CXCL8 TNC
22 prediabetes syndrome 10.0 AQP3 MIP
23 neuropathy, hereditary sensory and autonomic, type vi 10.0 BMP4 FBN1
24 t cell immunodeficiency primary 10.0 BMP2 BMP4 TGFB3
25 keratoconus 9.9
26 corneal disease 9.9
27 renovascular hypertension 9.9 CXCL8 IL1A
28 herpes simplex 9.8
29 astigmatism 9.8
30 classic type lipoma 9.8 BMP2 CXCL8 IL1A
31 limbal stem cell deficiency 9.7 BMP4 FBN1 IL1A NID1 TNC
32 aniridia 9.7
33 refractive error 9.7
34 insulin-like growth factor i 9.7
35 essential iris atrophy 9.7
36 acne 9.7
37 corneal endothelial dystrophy 9.7
38 open-angle glaucoma 9.7
39 corneal edema 9.7
40 myopia 9.7
41 corneal ulcer 9.7
42 contact lens corneal edema 8.6 AQP3 BMP2 BMP4 CXCL8 FBN1 IL1A

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 IL1A NID1 TGFB2 TGFB3 AQP3 BMP2
2 craniofacial MP:0005382 9.73 AQP3 BMP2 BMP4 FBN1 TGFB2 TGFB3
3 hearing/vestibular/ear MP:0005377 9.55 AQP3 BMP2 BMP4 TGFB2 TNC
4 limbs/digits/tail MP:0005371 9.35 BMP2 BMP4 FBN1 TGFB2 TGFB3
5 vision/eye MP:0005391 9.1 AQP3 BMP4 MIP NID1 TGFB2 TGFB3

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorometholone Approved Phase 2 426-13-1 9878
2
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5 Pharmaceutical Solutions Phase 2
6 Anesthetics Phase 2
7 Anti-Allergic Agents Phase 2
8 Antiemetics Phase 2
9 Anti-Inflammatory Agents Phase 2
10 Antineoplastic Agents, Hormonal Phase 2
11 Autonomic Agents Phase 2
12 Gastrointestinal Agents Phase 2
13 glucocorticoids Phase 2
14 Hormone Antagonists Phase 2
15 Hormones Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Methylprednisolone acetate Phase 2
18 Methylprednisolone Hemisuccinate Phase 2
19 Neuroprotective Agents Phase 2
20 Peripheral Nervous System Agents Phase 2
21 Prednisolone acetate Phase 2
22 Prednisolone hemisuccinate Phase 2
23 Prednisolone phosphate Phase 2
24 Protective Agents Phase 2
25 Angiogenesis Inhibitors Phase 2
26 Angiogenesis Modulating Agents Phase 2
27 Endothelial Growth Factors Phase 2
28 Mitogens Phase 2
29
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
30
Riboflavin Approved, Nutraceutical, Vet_approved 83-88-5 493570
31 Dermatologic Agents
32 Micronutrients
33 Photosensitizing Agents
34 Trace Elements
35 Vitamin B Complex
36 Vitamins
37 Alkylating Agents
38 Anti-Bacterial Agents
39 Antibiotics, Antitubercular
40 Mitomycins
41 Nucleic Acid Synthesis Inhibitors
42 Folate Nutraceutical
43 Vitamin B2 Nutraceutical
44 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
2 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2
3 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Enrolling by invitation NCT02790775 Phase 2
4 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
5 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
6 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252
7 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
8 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
9 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274
10 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888
11 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
12 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151
13 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
14 Corneal Transplantation Guided by OCT RESCAN Not yet recruiting NCT02736877
15 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

39
Endothelial, Eye, Testes

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 254)
id Title Authors Year
1
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
2
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. ( 27462256 )
2016
3
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. ( 27980363 )
2016
4
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. ( 27648049 )
2016
5
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. ( 27538190 )
2016
6
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. ( 26880480 )
2016
7
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
8
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. ( 27820951 )
2016
9
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. ( 25586624 )
2015
10
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. ( 25609910 )
2015
11
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. ( 26286755 )
2015
12
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. ( 26509766 )
2015
13
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. ( 26509077 )
2015
14
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. ( 26555584 )
2015
15
Case series and techniques of Descemet's Stripping Automated Endothelial Keratoplasty for severe bullous keratopathy after birth injury. ( 26245501 )
2015
16
Anterior corneal surface irregularity after Descemet-stripping endothelial keratoplasty for bullous keratopathy. ( 26541104 )
2015
17
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). ( 25959108 )
2015
18
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. ( 26491241 )
2015
19
Three-year outcome of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy. ( 24915015 )
2014
20
Regeneration of corneal endothelial cells following keratoplasty in rats with bullous keratopathy. ( 24883013 )
2014
21
Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs' Endothelial Dystrophy. ( 25484904 )
2014
22
Use of amniotic membrane in bullous keratopathy palliative care. ( 25870682 )
2014
23
Outcomes of corneal collagen crosslinking in pseudophakic bullous keratopathy. ( 24452209 )
2014
24
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). ( 25015213 )
2014
25
Femtosecond laser-assisted intracorneal biopolymer insertion for the symptomatic treatment of bullous keratopathy. ( 24619170 )
2014
26
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. ( 25627186 )
2014
27
Superficial epithelial keratectomy, cautery, and amniotic membrane transplant for the treatment of painful bullous keratopathy in eyes with poor visual potential. ( 24815111 )
2014
28
Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. ( 25088633 )
2014
29
Alternatives to corneal transplantation for the management of bullous keratopathy. ( 24807064 )
2014
30
Comparison of sulfur hexafluoride and air for donor attachment in Descemet stripping endothelial keratoplasty in patients with pseudophakic bullous keratopathy. ( 24452211 )
2014
31
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. ( 23957427 )
2013
32
Bullous keratopathy as a progressive disease: evidence from clinical and laboratory imaging studies. ( 24104939 )
2013
33
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. ( 23861578 )
2013
34
Complement activation in the aqueous humor of pseudophakic bullous keratopathy patients. ( 23258303 )
2013
35
'Dirty Picture!-Pleasant outcome' - A two step approach to anterior staphyloma and bullous keratopathy. ( 24600153 )
2013
36
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. ( 24373539 )
2013
37
Iridoschisis associated with nanophthalmos and bullous keratopathy. ( 23001742 )
2013
38
Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty. ( 24066132 )
2013
39
Descemet stripping automated endothelial keratoplasty for bullous keratopathy with an irregular posterior surface. ( 23846407 )
2013
40
Combined scraping, coagulation, and subconjunctival bevacizumab in Descemet stripping automated endothelial keratoplasty for bullous keratopathy. ( 23161181 )
2013
41
Management of bullous keratopathy-related ulcer with autologous serum. ( 22781466 )
2013
42
Descemet stripping automated endothelial keratoplasty for bullous keratopathy after anterior-posterior radial keratotomy. ( 23770978 )
2013
43
Endothelial keratoplasty for bullous keratopathy in eyes with an anterior chamber intraocular lens. ( 24286840 )
2013
44
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. ( 23974894 )
2013
45
Comparison of treatments for bullous keratopathy in rabbits. ( 23737903 )
2013
46
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. ( 23730105 )
2013
47
Role of corneal collagen cross-linking in pseudophakic bullous keratopathy: a clinicopathological study. ( 23953101 )
2013
48
Amniotic membrane transplantation versus anterior stromal puncture in bullous keratopathy: a comparative study. ( 23723410 )
2013
49
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. ( 22467587 )
2012
50
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. ( 23055672 )
2012

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2
2
Show member pathways
13.47 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
3
Show member pathways
13.35 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
4
Show member pathways
13.23 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
5
Show member pathways
13.1 AQP3 BMP2 BMP4 TGFB2 TGFB3
6
Show member pathways
13.09 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
7
Show member pathways
12.8 BMP2 BMP4 FBN1 TGFB2 TGFB3 TNC
8
Show member pathways
12.51 BMP2 BMP4 IL1A TGFB2 TGFB3
9 12.45 BMP2 BMP4 CXCL8 TGFB2 TGFB3
10
Show member pathways
12.3 BMP2 BMP4 TGFB2 TGFB3
11
Show member pathways
12.15 BMP2 BMP4 FBN1 NID1 TGFB2 TGFB3
12
Show member pathways
12.09 IL1A TGFB2 TGFB3
13 12.08 BMP4 TGFB2 TGFB3
14 12.07 IL1A TGFB2 TGFB3
15 11.97 BMP2 BMP4 TGFB2 TGFB3
16 11.8 BMP2 CXCL8 IL1A
17 11.75 CXCL8 TGFB2 TGFB3
18 11.7 CXCL8 IL1A TGFB2 TGFB3
19 11.69 TGFB2 TGFB3 TNC
20 11.65 BMP2 BMP4 TGFB2 TGFB3
21 11.58 BMP2 BMP4 TGFB2 TGFB3
22 11.58 CXCL8 IL1A TGFB2 TGFB3
23 11.54 BMP2 BMP4 TGFB2 TGFB3
24 11.48 BMP2 BMP4 TGFB2 TGFB3
25 11.47 TGFB2 TGFB3 TNC
26 11.39 CXCL8 TGFB2 TGFB3
27 11.13 TGFB2 TGFB3
28 11.03 BMP2 BMP4
29 10.97 BMP2 BMP4
30 10.94 TGFB2 TGFB3
31
Show member pathways
10.88 BMP2 BMP4 FBN1 TGFB2 TGFB3
32 10.79 TGFB2 TGFB3
33 10.78 BMP2 BMP4 CXCL8 IL1A TGFB3

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.62 BMP4 FBN1 NID1 TNC
2 extracellular region GO:0005576 9.61 BMP2 BMP4 CXCL8 FBN1 IL1A NID1
3 extracellular matrix GO:0031012 9.55 FBN1 NID1 TGFB2 TGFB3 TNC
4 basement membrane GO:0005604 9.43 FBN1 NID1 TNC
5 extracellular space GO:0005615 9.28 BMP2 BMP4 CXCL8 FBN1 IL1A NID1

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.9 BMP2 BMP4 FBN1 TGFB2
2 cellular protein metabolic process GO:0044267 9.89 BMP4 FBN1 TNC
3 negative regulation of gene expression GO:0010629 9.87 BMP2 BMP4 TGFB2
4 response to hypoxia GO:0001666 9.87 BMP2 TGFB2 TGFB3
5 extracellular matrix organization GO:0030198 9.87 FBN1 NID1 TGFB2 TNC
6 osteoblast differentiation GO:0001649 9.83 BMP2 BMP4 TNC
7 kidney development GO:0001822 9.83 BMP4 FBN1 TGFB2
8 wound healing GO:0042060 9.82 TGFB2 TGFB3 TNC
9 skeletal system development GO:0001501 9.8 BMP2 BMP4 FBN1 TGFB2
10 positive regulation of gene expression GO:0010628 9.8 BMP2 BMP4 IL1A TGFB2 TNC
11 odontogenesis of dentin-containing tooth GO:0042475 9.76 BMP2 BMP4 TNC
12 inner ear development GO:0048839 9.75 BMP2 TGFB2 TGFB3
13 cell development GO:0048468 9.73 BMP2 TGFB2 TGFB3
14 negative regulation of cell proliferation GO:0008285 9.73 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
15 cellular response to BMP stimulus GO:0071773 9.72 BMP2 BMP4
16 positive regulation of cell division GO:0051781 9.72 IL1A TGFB2 TGFB3
17 lung alveolus development GO:0048286 9.71 BMP4 TGFB3
18 metanephros development GO:0001656 9.71 BMP4 FBN1
19 neuron fate commitment GO:0048663 9.71 BMP4 TGFB2
20 face morphogenesis GO:0060325 9.71 TGFB2 TGFB3
21 cardiac muscle cell differentiation GO:0055007 9.7 BMP2 BMP4
22 telencephalon development GO:0021537 9.7 BMP2 BMP4
23 positive regulation of protein secretion GO:0050714 9.7 IL1A TGFB2 TGFB3
24 positive regulation of collagen biosynthetic process GO:0032967 9.69 BMP4 TGFB3
25 outflow tract septum morphogenesis GO:0003148 9.69 BMP4 TGFB2
26 cell-cell junction organization GO:0045216 9.69 TGFB2 TGFB3
27 positive regulation of epithelial to mesenchymal transition GO:0010718 9.69 BMP2 TGFB2 TGFB3
28 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.68 BMP2 BMP4
29 embryonic digestive tract development GO:0048566 9.68 CXCL8 TGFB2
30 water transport GO:0006833 9.68 AQP3 MIP
31 positive regulation of cartilage development GO:0061036 9.68 BMP2 BMP4
32 endocardial cushion morphogenesis GO:0003203 9.67 BMP2 TGFB2
33 pathway-restricted SMAD protein phosphorylation GO:0060389 9.67 BMP2 TGFB2
34 cardiac epithelial to mesenchymal transition GO:0060317 9.67 BMP2 TGFB2
35 BMP signaling pathway GO:0030509 9.67 BMP2 BMP4 TGFB2 TGFB3
36 cardiac right ventricle morphogenesis GO:0003215 9.66 BMP4 TGFB2
37 positive regulation of SMAD protein import into nucleus GO:0060391 9.65 BMP4 TGFB3
38 atrioventricular valve morphogenesis GO:0003181 9.65 BMP2 TGFB2
39 positive regulation of bone mineralization GO:0030501 9.65 BMP2 BMP4 TGFB3
40 salivary gland morphogenesis GO:0007435 9.64 TGFB2 TGFB3
41 membranous septum morphogenesis GO:0003149 9.63 BMP4 TGFB2
42 pulmonary valve morphogenesis GO:0003184 9.63 BMP4 TGFB2
43 SMAD protein import into nucleus GO:0007184 9.62 TGFB2 TGFB3
44 telencephalon regionalization GO:0021978 9.62 BMP2 BMP4
45 pharyngeal arch artery morphogenesis GO:0061626 9.61 BMP4 TGFB2
46 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.61 BMP2 BMP4
47 negative regulation of macrophage cytokine production GO:0010936 9.59 TGFB2 TGFB3
48 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.54 BMP2 BMP4
49 positive regulation of ossification GO:0045778 9.5 BMP2 BMP4 TGFB2
50 uterine wall breakdown GO:0042704 9.46 TGFB2 TGFB3

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 BMP2 BMP4 TGFB2 TGFB3
2 water channel activity GO:0015250 9.43 AQP3 MIP
3 co-receptor binding GO:0039706 9.4 BMP2 BMP4
4 BMP receptor binding GO:0070700 9.37 BMP2 BMP4
5 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFB3
6 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB2 TGFB3
7 transforming growth factor beta receptor binding GO:0005160 9.26 BMP2 BMP4 TGFB2 TGFB3
8 cytokine activity GO:0005125 9.1 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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