MCID: BLL004
MIFTS: 43

Bullous Keratopathy malady

Eye diseases category
Download this MalaCard

Summaries for Bullous Keratopathy

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

MalaCards: Bullous Keratopathy is related to glaucoma and keratoconus. An important gene associated with Bullous Keratopathy is TNC (tenascin C), and among its related pathways are ECM proteoglycans and Angiogenesis. The compounds procollagen and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Bullous Keratopathy

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

bullous keratopathy 8 10 45 62


External Ids:

Disease Ontology8 DOID:11031
ICD9CM27 371.23
SNOMED-CT58 193815002, 57207003
NCIt40 C26970
ICD1025 H18.1

Related Diseases for Bullous Keratopathy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to bullous keratopathy

Symptoms for Bullous Keratopathy

About this section

Drugs & Therapeutics for Bullous Keratopathy

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Bullous Keratopathy

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

About this section

Anatomical Context for Bullous Keratopathy

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bullous Keratopathy:

33
Endothelial, Eye, Testes

Animal Models for Bullous Keratopathy or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Bullous Keratopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0IL1A, SOD3, TGFB2, FBN1
2MP:00053767.2IL1A, SOD3, TGFB2, TNC, FBN1

Publications for Bullous Keratopathy

About this section
Sources:
52PubMed
See all sources

Articles related to Bullous Keratopathy:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
2
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
3
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
4
Comparison of treatments for bullous keratopathy in rabbits. (23737903)
2013
5
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. (23861578)
2013
6
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. (23957427)
2013
7
Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty. (22153314)
2012
8
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012
9
Rationale for performing penetrating keratoplasty rather than DSAEK in patients with bullous keratopathy in Japan. (22869384)
2012
10
Descemetorrhexis in endothelial keratoplasty to avoid peripheral bullous keratopathy. (22687300)
2012
11
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. (22467587)
2012
12
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
13
Corneal nerve aberrations in bullous keratopathy. (21310389)
2011
14
Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy. (21866044)
2011
15
Sutureless amniotic membrane fixation with fibrin glue in symptomatic bullous keratopathy with poor visual potential. (20047183)
2010
16
Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. (20142847)
2010
17
A chandelier-illuminated anterior chamber maintainer for use during descemet stripping automated endothelial keratoplasty in patients with advanced bullous keratopathy. (20508515)
2010
18
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
19
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
20
Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. (16848159)
2006
21
Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. (16186344)
2005
22
Recurrence of giant pseudocyst in advanced bullous keratopathy. (14976545)
2004
23
Long-term follow-up for bullous keratopathy after sato-type anterior-posterior corneal refractive surgery. (14644229)
2003
24
Response to symptomatic management of postoperative bullous keratopathy with nonpreserved human amniotic membrane. (12605061)
2003
25
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
26
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. (11668187)
2001
27
Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. (11446768)
2001
28
Ophthaproblem. Pseudophakic bullous keratopathy. (10907565)
2000
29
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma. (9493117)
1998
30
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)
1995
31
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
32
Proteoglycan distribution in the corneas of individuals with bullous keratopathy. (2083765)
1990
33
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
34
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
35
The bandage lens in bullous keratopathy. (2594381)
1989
36
Penetrating keratoplasty for pseudophakic bullous keratopathy. Management of the intraocular lens. (3062537)
1988
37
Intraocular lens removal during penetrating keratoplasty for pseudophakic bullous keratopathy. (3299201)
1987
38
Results of penetrating keratoplasty for aphakic bullous keratopathy. (3155046)
1986
39
Pseudophakic bullous keratopathy: relationship with endothelial cell density and use of a predictive cell loss model. A preliminary report. (3720342)
1986
40
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
41
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
42
Endothelial wound-healing in penetrating corneal graft for experimental bullous keratopathy in rabbit. (2421030)
1985
43
Bullous keratopathy: a perspective on the American experience. (6478579)
1984
44
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. (7081358)
1982
45
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
46
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977
47
Histopathologic findings in corneas following lens extraction and results of keratoplasty for aphakic bullous keratopathy. (4940981)
1971
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Clinical observations on the treatment of bullous keratopathy. (13556833)
1957-1958
50
Studies on the clinical physiology of the cornea; the interrelationship of corneal turgescence, epithelial edema, bullous keratopathy, and interstitial vascularization. (18121090)
1949

Variations for Bullous Keratopathy

About this section

Expression for genes affiliated with Bullous Keratopathy

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for genes affiliated with Bullous Keratopathy

About this section
Sources:
50PathCards, 55Reactome, 5Cell Signaling Technology, 30KEGG, 53QIAGEN
See all sources

Compounds for genes affiliated with Bullous Keratopathy

About this section
Sources:
45Novoseek, 24HMDB, 3BitterDB, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 29IUPHAR
See all sources

Compounds related to Bullous Keratopathy according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1procollagen459.8IL1A, TNC
2manganese superoxide459.8SOD3, IL1A
3neopterin459.7IL1A, TGFB2
4p003459.7TNC, TGFB2
5uric acid45 2410.6SOD3, TGFB2
6formaldehyde45 2410.6IL1A, TNC
71,25 dihydroxy vitamin d3459.6IL1A, TGFB2
8hydrocortisone45 3 61 1112.5IL1A, TGFB2
9chondroitin sulfate45 2410.5TNC, FBN1
10egcg459.5IL1A, TGFB2
11sodium dodecylsulfate459.4FBN1, IL1A
12homocysteine45 2410.3FBN1, SOD3
13prostaglandin459.3IL1A, TGFB2
14h2o2459.3IL1A, SOD3, TNC
15glycosaminoglycan459.3IL1A, TGFB2, TNC
16calcitriol45 61 24 1112.2TGFB2, IL1A
17creatinine459.2TNC, TGFB2, IL1A
18cycloheximide459.2IL1A, TGFB2, TNC
19dexamethasone45 51 29 1112.2TNC, TGFB2, IL1A
20nitric oxide45 24 1111.1IL1A, SOD3, TGFB2
21heparan sulfate45 2410.1FBN1, TNC, SOD3
22vitamin a45 24 1111.0IL1A, TGFB2
23tgf beta1459.0FBN1, TNC, TGFB2
24arginine458.9FBN1, SOD3, IL1A
25vegf458.7IL1A, SOD3, TGFB2, TNC
26estrogen458.7FBN1, TNC, TGFB2
27lipid458.7SOD3, TNC, FBN1
28hyaluronic acid45 249.5FBN1, TNC, TGFB2, IL1A
29progesterone45 29 61 24 1112.4FBN1, TNC, TGFB2, IL1A
30glutamate458.4IL1A, TGFB2, TNC, FBN1
31retinoic acid45 249.4FBN1, TNC, TGFB2, IL1A
32cysteine458.4SOD3, TGFB2, TNC, FBN1
33vitamin d458.4IL1A, SOD3, TGFB2, FBN1
34ascorbic acid45 248.9IL1A, SOD3, TGFB2, TNC, FBN1
35heparin45 29 24 1110.9FBN1, TNC, TGFB2, SOD3, IL1A
36serine457.9FBN1, TNC, TGFB2, SOD3, IL1A

GO Terms for genes affiliated with Bullous Keratopathy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Bullous Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.2TNC, FBN1
2extracellular matrixGO:0310128.1SOD3, TGFB2, TNC, FBN1
3extracellular spaceGO:0056157.4FBN1, TNC, TGFB2, SOD3, IL1A
4extracellular regionGO:0055767.2IL1A, SOD3, TGFB2, TNC, FBN1

Biological processes related to Bullous Keratopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:0466889.6IL1A, SOD3
2response to woundingGO:0096119.5TNC, TGFB2
3positive regulation of cell divisionGO:0517819.4IL1A, TGFB2
4wound healingGO:0420609.4TGFB2, TNC
5response to hypoxiaGO:0016669.3SOD3, TGFB2
6positive regulation of gene expressionGO:0106289.3TGFB2, TNC
7heart developmentGO:0075078.7TGFB2, FBN1
8extracellular matrix organizationGO:0301988.7TGFB2, TNC, FBN1

Molecular functions related to Bullous Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3IL1A, TGFB2
2copper ion bindingGO:0055079.1IL1A, SOD3

Products for genes affiliated with Bullous Keratopathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bullous Keratopathy

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet