MCID: BLL004
MIFTS: 36

Bullous Keratopathy malady

Eye diseases category

Aliases & Classifications for Bullous Keratopathy

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 25ICD10
See all sources

Bullous Keratopathy, Aliases & Descriptions:

Name: Bullous Keratopathy 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:11031
ICD9CM27 371.23
SNOMED-CT55 57207003, 193815002
NCIt38 C26970
ICD1025 H18.1

Summaries for Bullous Keratopathy

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Wikipedia:63 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

MalaCards based summary: Bullous Keratopathy is related to keratoconus and corneal disease. An important gene associated with Bullous Keratopathy is TNC (tenascin C), and among its related pathways are ECM proteoglycans and Angiogenesis. The compounds procollagen and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Related Diseases for Bullous Keratopathy

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Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to bullous keratopathy

Symptoms for Bullous Keratopathy

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Drugs & Therapeutics for Bullous Keratopathy

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Drug clinical trials:

Search ClinicalTrials for Bullous Keratopathy

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

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Anatomical Context for Bullous Keratopathy

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MalaCards organs/tissues related to Bullous Keratopathy:

31
Endothelial, Eye, Testes

Animal Models for Bullous Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Bullous Keratopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0IL1A, SOD3, TGFB2, FBN1
2MP:00053767.2IL1A, SOD3, TGFB2, TNC, FBN1

Publications for Bullous Keratopathy

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Articles related to Bullous Keratopathy:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
2
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. (25627186)
2014
3
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
4
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
5
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
6
Comparison of treatments for bullous keratopathy in rabbits. (23737903)
2013
7
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. (23861578)
2013
8
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. (23957427)
2013
9
Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty. (22153314)
2012
10
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012
11
Rationale for performing penetrating keratoplasty rather than DSAEK in patients with bullous keratopathy in Japan. (22869384)
2012
12
Descemetorrhexis in endothelial keratoplasty to avoid peripheral bullous keratopathy. (22687300)
2012
13
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. (22467587)
2012
14
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
15
Corneal nerve aberrations in bullous keratopathy. (21310389)
2011
16
Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy. (21866044)
2011
17
Sutureless amniotic membrane fixation with fibrin glue in symptomatic bullous keratopathy with poor visual potential. (20047183)
2010
18
Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. (20142847)
2010
19
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
20
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
21
Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. (16848159)
2006
22
Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. (16186344)
2005
23
Recurrence of giant pseudocyst in advanced bullous keratopathy. (14976545)
2004
24
Long-term follow-up for bullous keratopathy after sato-type anterior-posterior corneal refractive surgery. (14644229)
2003
25
Response to symptomatic management of postoperative bullous keratopathy with nonpreserved human amniotic membrane. (12605061)
2003
26
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
27
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. (11668187)
2001
28
Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. (11446768)
2001
29
Ophthaproblem. Pseudophakic bullous keratopathy. (10907565)
2000
30
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma. (9493117)
1998
31
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)
1995
32
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
33
Proteoglycan distribution in the corneas of individuals with bullous keratopathy. (2083765)
1990
34
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
35
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
36
The bandage lens in bullous keratopathy. (2594381)
1989
37
Penetrating keratoplasty for pseudophakic bullous keratopathy. Management of the intraocular lens. (3062537)
1988
38
Intraocular lens removal during penetrating keratoplasty for pseudophakic bullous keratopathy. (3299201)
1987
39
Results of penetrating keratoplasty for aphakic bullous keratopathy. (3155046)
1986
40
Pseudophakic bullous keratopathy: relationship with endothelial cell density and use of a predictive cell loss model. A preliminary report. (3720342)
1986
41
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
42
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
43
Bullous keratopathy: a perspective on the American experience. (6478579)
1984
44
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. (7081358)
1982
45
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
46
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977
47
Histopathologic findings in corneas following lens extraction and results of keratoplasty for aphakic bullous keratopathy. (4940981)
1971
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Clinical observations on the treatment of bullous keratopathy. (13556833)
1957-1958
50
Studies on the clinical physiology of the cornea; the interrelationship of corneal turgescence, epithelial edema, bullous keratopathy, and interstitial vascularization. (18121090)
1949

Variations for Bullous Keratopathy

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Expression for genes affiliated with Bullous Keratopathy

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Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for genes affiliated with Bullous Keratopathy

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Compounds for genes affiliated with Bullous Keratopathy

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Compounds related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 36)
idCompoundScoreTop Affiliating Genes
1procollagen439.8IL1A, TNC
2manganese superoxide439.8SOD3, IL1A
3neopterin439.7IL1A, TGFB2
4p003439.7TNC, TGFB2
5uric acid43 2410.6SOD3, TGFB2
6formaldehyde43 2410.6IL1A, TNC
71,25 dihydroxy vitamin d3439.6IL1A, TGFB2
8hydrocortisone43 2 59 1212.5IL1A, TGFB2
9chondroitin sulfate43 2410.5TNC, FBN1
10egcg439.5IL1A, TGFB2
11sodium dodecylsulfate439.4FBN1, IL1A
12homocysteine43 2410.3FBN1, SOD3
13prostaglandin439.3IL1A, TGFB2
14h2o2439.3IL1A, SOD3, TNC
15glycosaminoglycan439.3IL1A, TGFB2, TNC
16calcitriol43 59 24 1212.2TGFB2, IL1A
17creatinine439.2TNC, TGFB2, IL1A
18cycloheximide439.2IL1A, TGFB2, TNC
19dexamethasone43 49 28 1212.2TNC, TGFB2, IL1A
20nitric oxide43 24 1211.1IL1A, SOD3, TGFB2
21heparan sulfate43 2410.1FBN1, TNC, SOD3
22vitamin a43 24 1211.0IL1A, TGFB2
23tgf beta1439.0FBN1, TNC, TGFB2
24arginine438.9FBN1, SOD3, IL1A
25vegf438.7IL1A, SOD3, TGFB2, TNC
26estrogen438.7FBN1, TNC, TGFB2
27lipid438.7SOD3, TNC, FBN1
28hyaluronic acid43 249.5FBN1, TNC, TGFB2, IL1A
29progesterone43 28 59 24 1212.4FBN1, TNC, TGFB2, IL1A
30glutamate438.4IL1A, TGFB2, TNC, FBN1
31retinoic acid43 249.4FBN1, TNC, TGFB2, IL1A
32cysteine438.4SOD3, TGFB2, TNC, FBN1
33vitamin d438.4IL1A, SOD3, TGFB2, FBN1
34ascorbic acid43 248.9IL1A, SOD3, TGFB2, TNC, FBN1
35heparin43 28 24 1210.9FBN1, TNC, TGFB2, SOD3, IL1A
36serine437.9FBN1, TNC, TGFB2, SOD3, IL1A

GO Terms for genes affiliated with Bullous Keratopathy

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Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.2TNC, FBN1
2extracellular matrixGO:00310128.1SOD3, TGFB2, TNC, FBN1
3extracellular spaceGO:00056157.4FBN1, TNC, TGFB2, SOD3, IL1A
4extracellular regionGO:00055767.2IL1A, SOD3, TGFB2, TNC, FBN1

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:00466889.6IL1A, SOD3
2response to woundingGO:00096119.5TNC, TGFB2
3positive regulation of cell divisionGO:00517819.4IL1A, TGFB2
4wound healingGO:00420609.4TGFB2, TNC
5response to hypoxiaGO:00016669.3SOD3, TGFB2
6positive regulation of gene expressionGO:00106289.3TGFB2, TNC
7heart developmentGO:00075078.7TGFB2, FBN1
8extracellular matrix organizationGO:00301988.7TGFB2, TNC, FBN1

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.3IL1A, TGFB2
2copper ion bindingGO:00055079.1IL1A, SOD3

Products for genes affiliated with Bullous Keratopathy

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Sources for Bullous Keratopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet