Aliases & Classifications for Bullous Keratopathy

About this section
Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 29ICD9CM, 59SNOMED-CT, 42NCIt, 27ICD10
See all sources

Aliases & Descriptions for Bullous Keratopathy:

Name: Bullous Keratopathy 10 47 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:11031
ICD9CM29 371.23
SNOMED-CT59 193815002, 57207003
NCIt42 C26970
ICD1027 H18.1

Summaries for Bullous Keratopathy

About this section
Wikipedia:68 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

MalaCards based summary: Bullous Keratopathy is related to keratoconus and open-angle glaucoma. An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways are Cytokines and Inflammatory Response and ALK1 signaling events. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are hearing/vestibular/ear and digestive/alimentary.

Related Diseases for Bullous Keratopathy

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Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconus30.5TGFB1, TGFB3, TNC
2open-angle glaucoma30.0AQP1, AQP3
3keratopathy11.4
4endotheliitis11.0
5cataract10.6
6keratitis10.5
7corneal disease10.5
8fuchs' endothelial dystrophy10.5
9astigmatism10.3
10corneal edema10.3
11eye disease10.3
12globe disease10.3
13herpes simplex10.3
14acromicric dysplasia10.2FBN1, TGFB2
15aniridia10.2
16pick disease10.2
17insulin-like growth factor i10.2
18acne10.2
19contact lens corneal edema10.2
20phototoxic dermatitis10.2
21pain disorder10.2
22spiradenoma10.2
23corneal neovascularization10.2
24corneal ulcer10.2
25lens disease10.2
26myopia10.2
27refractive error10.2
28chiari malformation type 210.2
29fetal edema10.2
30chronic pain10.2
31essential iris atrophy10.2
32bladder urothelial papillary carcinoma10.1FBN1, TGFB1
33shprintzen-goldberg syndrome10.1FBN1, TGFB1
34premature chromatid separation trait10.1TGFB2, TGFB3
35clear cell adenocarcinoma10.1TGFB2, TGFB3
36genetic prion diseases10.1FBN1, TGFB1
37vulva adenocarcinoma10.1TGFB1, TGFB2
38antley-bixler syndrome10.0FBN1, TGFB2, TGFB3
39epididymal neoplasm10.0AQP1, AQP3
40chronic ulcer of skin9.9FBN1, TGFB1, TGFB3
41pulmonary fibrosis, idiopathic9.9IL1A, TGFB1, TNC
42melas syndrome9.9TGFB1, TGFB2, TGFB3
43impetigo9.9AQP1, AQP3
44pulmonary hypertension9.9TGFB1, TGFB3
45splenic flexure cancer9.9BMP4, TGFB1
46dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease9.9AQP1, MIP
47benign dermal neurilemmoma9.9AQP1, AQP3
48phlebotomus fever9.8AQP1, TGFB1
49meningeal melanoma9.7AQP1, AQP3, MIP
50diabetes insipidus, nephrogenic9.7AQP1, AQP3, MIP

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to bullous keratopathy

Symptoms for Bullous Keratopathy

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Drugs & Therapeutics for Bullous Keratopathy

About this section

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrednisoloneapprovedPhase 2103350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
2
FluorometholoneapprovedPhase 217426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Flarex
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
Fluorometholone (JP15/USP/INN)
 
Fluorometholone Acetate
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml
Fml (TN)
Fml Forte
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
3
MethylprednisoloneapprovedPhase 2103383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
4Prednisolone hemisuccinatePhase 21033
5Prednisolone acetatePhase 21033
6Prednisolone phosphatePhase 21033
7Methylprednisolone HemisuccinatePhase 21033
8Methylprednisolone acetatePhase 21033
9
Folic Acidapproved, nutraceutical285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
10
Riboflavinapproved, nutraceutical13883-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
Hyre
Lactobene
 
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavin
Riboflavin phosphate sodium dihydrate
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
e101
11Mitomycins208
12Vitamin B Complex2775
13Vitamin B9Nutraceutical2851
14Vitamin B2Nutraceutical138
15FolateNutraceutical2851

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Amniotic Membrane Graft In Syntomathic Bullous KeratopathyCompletedNCT01926535Phase 2
2Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)CompletedNCT01448213Phase 2
3Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous KeratopathyCompletedNCT00659308
4The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous KeratopathyCompletedNCT01106274
5Automated Lamellar Keratectomy in Symptomatic Patients With Bullous KeratopathyCompletedNCT00654888
6The SNEC DSAEK EndoGlide Clinical TrialRecruitingNCT01122043
7Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)RecruitingNCT02020044
8Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
9Comparing Endoglide to Endoserter for DSAEK Graft InsertionRecruitingNCT01791075
10Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture MediaNot yet recruitingNCT00623584
11Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal EdemaNot yet recruitingNCT02660151
12Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal EdemaNot yet recruitingNCT01890252
13Topical Steroid Treatment After Posterior Lamellar Corneal TransplantationWithdrawnNCT01682421

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

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Anatomical Context for Bullous Keratopathy

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MalaCards organs/tissues related to Bullous Keratopathy:

33
Endothelial, Eye, Testes

Animal Models for Bullous Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Bullous Keratopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6AQP1, AQP3, BMP4, TGFB2, TNC
2MP:00053818.5AQP3, BMP4, TGFB1, TGFB2, TGFB3
3MP:00053828.3AQP3, BMP4, FBN1, TGFB1, TGFB2, TGFB3
4MP:00053677.9AQP1, AQP3, BMP4, FBN1, TGFB1, TGFB2
5MP:00053887.2AQP1, AQP3, BMP4, FBN1, TGFB1, TGFB2
6MP:00053916.6AQP1, AQP3, BMP4, MIP, NID1, TGFB1
7MP:00053866.5AQP1, AQP3, BMP4, FBN1, NID1, TGFB1
8MP:00053856.4AQP1, AQP3, BMP4, FBN1, IL1A, NID1
9MP:00053766.4AQP1, AQP3, BMP4, FBN1, IL1A, TGFB1
10MP:00036316.4AQP1, BMP4, FBN1, NID1, TGFB1, TGFB2

Publications for Bullous Keratopathy

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Articles related to Bullous Keratopathy:

(show top 50)    (show all 244)
idTitleAuthorsYear
1
Case series and techniques of Descemet's Stripping Automated Endothelial Keratoplasty for severe bullous keratopathy after birth injury. (26245501)
2015
2
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. (26509766)
2015
3
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. (26491241)
2015
4
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). (25959108)
2015
5
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
6
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. (25627186)
2014
7
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
8
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
9
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
10
Comparison of treatments for bullous keratopathy in rabbits. (23737903)
2013
11
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. (23861578)
2013
12
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. (23957427)
2013
13
Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty. (22153314)
2012
14
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012
15
Rationale for performing penetrating keratoplasty rather than DSAEK in patients with bullous keratopathy in Japan. (22869384)
2012
16
Descemetorrhexis in endothelial keratoplasty to avoid peripheral bullous keratopathy. (22687300)
2012
17
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
18
Corneal nerve aberrations in bullous keratopathy. (21310389)
2011
19
Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy. (21866044)
2011
20
Sutureless amniotic membrane fixation with fibrin glue in symptomatic bullous keratopathy with poor visual potential. (20047183)
2010
21
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
22
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
23
Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. (16186344)
2005
24
Recurrence of giant pseudocyst in advanced bullous keratopathy. (14976545)
2004
25
Long-term follow-up for bullous keratopathy after sato-type anterior-posterior corneal refractive surgery. (14644229)
2003
26
Response to symptomatic management of postoperative bullous keratopathy with nonpreserved human amniotic membrane. (12605061)
2003
27
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
28
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. (11668187)
2001
29
Ophthaproblem. Pseudophakic bullous keratopathy. (10907565)
2000
30
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma. (9493117)
1998
31
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)
1995
32
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
33
Proteoglycan distribution in the corneas of individuals with bullous keratopathy. (2083765)
1990
34
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
35
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
36
The bandage lens in bullous keratopathy. (2594381)
1989
37
Penetrating keratoplasty for pseudophakic bullous keratopathy. Management of the intraocular lens. (3062537)
1988
38
Intraocular lens removal during penetrating keratoplasty for pseudophakic bullous keratopathy. (3299201)
1987
39
Results of penetrating keratoplasty for aphakic bullous keratopathy. (3155046)
1986
40
Pseudophakic bullous keratopathy: relationship with endothelial cell density and use of a predictive cell loss model. A preliminary report. (3720342)
1986
41
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
42
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
43
Bullous keratopathy: a perspective on the American experience. (6478579)
1984
44
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. (7081358)
1982
45
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
46
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977
47
Histopathologic findings in corneas following lens extraction and results of keratoplasty for aphakic bullous keratopathy. (4940981)
1971
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Clinical observations on the treatment of bullous keratopathy. (13556833)
1957-1958
50
Studies on the clinical physiology of the cornea; the interrelationship of corneal turgescence, epithelial edema, bullous keratopathy, and interstitial vascularization. (18121090)
1949

Variations for Bullous Keratopathy

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Expression for genes affiliated with Bullous Keratopathy

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Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for genes affiliated with Bullous Keratopathy

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Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL1A, TGFB1
2
Show member pathways
9.3TGFB1, TGFB3
39.3TGFB1, TGFB3
49.3IL1A, TGFB1, TGFB2
5
Show member pathways
9.1NID1, TGFB1, TNC
69.0TGFB1, TGFB2, TGFB3
79.0TGFB1, TGFB2, TGFB3
8
Show member pathways
9.0TGFB1, TGFB2, TGFB3
99.0TGFB1, TGFB2, TGFB3
10
Show member pathways
9.0TGFB1, TGFB2, TGFB3
11
Show member pathways
9.0TGFB1, TGFB2, TGFB3
129.0TGFB1, TGFB2, TGFB3
139.0TGFB1, TGFB2, TGFB3
14
Show member pathways
9.0TGFB1, TGFB2, TGFB3
15
Show member pathways
9.0TGFB1, TGFB2, TGFB3
169.0TGFB1, TGFB2, TGFB3
17
Show member pathways
9.0TGFB1, TGFB2, TGFB3
189.0TGFB1, TGFB2, TGFB3
199.0TGFB1, TGFB2, TGFB3
208.8AQP1, IL1A, TGFB1
21
Angiogenesis (CST)
Show member pathways
8.7AQP1, IL1A, TGFB1
228.7TGFB1, TGFB2, TGFB3, TNC
23
Show member pathways
8.7IL1A, TGFB1, TGFB2, TGFB3
24
Show member pathways
8.7IL1A, TGFB1, TGFB2, TGFB3
258.7IL1A, TGFB1, TGFB2, TGFB3
268.7IL1A, TGFB1, TGFB2, TGFB3
278.7IL1A, TGFB1, TGFB2, TGFB3
28
TGF-beta signaling pathway (KEGG)
Show member pathways
8.6IL1A, TGFB1, TGFB2, TGFB3
29
TGF-beta Signaling Pathway (sino)
Show member pathways
8.6IL1A, TGFB1, TGFB2, TGFB3
308.6BMP4, TGFB1, TGFB2, TGFB3
318.6BMP4, TGFB1, TGFB2, TGFB3
328.6BMP4, TGFB1, TGFB2, TGFB3
33
Show member pathways
8.6BMP4, TGFB1, TGFB2, TGFB3
348.6BMP4, TGFB1, TGFB2, TGFB3
35
Show member pathways
8.3BMP4, FBN1, TGFB1, TGFB2, TGFB3
36
Show member pathways
8.3BMP4, IL1A, TGFB1, TGFB2, TGFB3
37
Show member pathways
8.1BMP4, FBN1, TGFB1, TGFB2, TGFB3, TNC
38
Show member pathways
7.5BMP4, FBN1, NID1, TGFB1, TGFB2, TGFB3
39
Show member pathways
7.4AQP1, AQP3, BMP4, TGFB1, TGFB2, TGFB3

GO Terms for genes affiliated with Bullous Keratopathy

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Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6TGFB1, TGFB2, TGFB3
2basement membraneGO:00056049.4FBN1, NID1, TNC
3extracellular matrixGO:00310128.3FBN1, NID1, TGFB2, TGFB3, TNC
4proteinaceous extracellular matrixGO:00055788.3BMP4, FBN1, NID1, TGFB1, TGFB3
5extracellular spaceGO:00056157.7BMP4, FBN1, IL1A, TGFB1, TGFB2, TGFB3
6extracellular regionGO:00055766.9BMP4, FBN1, IL1A, NID1, TGFB1, TGFB2

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:004866310.4BMP4, TGFB2
2connective tissue replacement involved in inflammatory response wound healingGO:000224810.3IL1A, TGFB1
3positive regulation of ossificationGO:004577810.3BMP4, TGFB2
4common-partner SMAD protein phosphorylationGO:000718210.3BMP4, TGFB1
5regulation of protein import into nucleusGO:004230610.3BMP4, TGFB1
6regulation of cartilage developmentGO:006103510.3BMP4, TGFB1
7pathway-restricted SMAD protein phosphorylationGO:006038910.2TGFB1, TGFB2
8uterine wall breakdownGO:004270410.2TGFB2, TGFB3
9positive regulation of vascular endothelial growth factor productionGO:001057510.1IL1A, TGFB1
10negative regulation of myoblast differentiationGO:004566210.0BMP4, TGFB1
11frontal suture morphogenesisGO:006036410.0TGFB1, TGFB3
12response to laminar fluid shear stressGO:003461610.0TGFB1, TGFB3
13response to vitamin DGO:00332809.9AQP3, TGFB1
14response to woundingGO:00096119.9TGFB1, TGFB2, TNC
15negative regulation of DNA replicationGO:00081569.9TGFB1, TGFB3
16ossification involved in bone remodelingGO:00439329.8TGFB1, TGFB3
17negative regulation of epithelial cell proliferationGO:00506809.8BMP4, TGFB1, TGFB2
18renal water homeostasisGO:00030919.8AQP1, AQP3
19skeletal system developmentGO:00015019.7BMP4, FBN1, TGFB2
20SMAD protein import into nucleusGO:00071849.6TGFB1, TGFB2, TGFB3
21negative regulation of macrophage cytokine productionGO:00109369.6TGFB1, TGFB2, TGFB3
22negative regulation of immune responseGO:00507779.6TGFB1, TGFB2
23positive regulation of collagen biosynthetic processGO:00329679.6BMP4, TGFB1, TGFB3
24positive regulation of epithelial to mesenchymal transitionGO:00107189.6TGFB1, TGFB2, TGFB3
25salivary gland morphogenesisGO:00074359.6TGFB1, TGFB2, TGFB3
26positive regulation of SMAD protein import into nucleusGO:00603919.6BMP4, TGFB1, TGFB3
27response to progesteroneGO:00325709.6TGFB1, TGFB2, TGFB3
28platelet degranulationGO:00025769.5TGFB1, TGFB2, TGFB3
29positive regulation of bone mineralizationGO:00305019.5BMP4, TGFB1, TGFB3
30face morphogenesisGO:00603259.5TGFB1, TGFB2, TGFB3
31cell-cell junction organizationGO:00452169.5TGFB1, TGFB2, TGFB3
32cell developmentGO:00484689.4TGFB1, TGFB2, TGFB3
33cellular water homeostasisGO:00099929.4AQP1, AQP3, MIP
34glycerol transportGO:00157939.4AQP1, AQP3, MIP
35cellular response to dexamethasone stimulusGO:00715499.4AQP1, TGFB1
36water transportGO:00068339.4AQP1, AQP3, MIP
37response to hypoxiaGO:00016669.3TGFB1, TGFB2, TGFB3
38positive regulation of cell proliferationGO:00082849.3BMP4, TGFB1, TGFB2, TNC
39cellular response to growth factor stimulusGO:00713639.3BMP4, TGFB1, TGFB3
40positive regulation of protein secretionGO:00507149.3IL1A, TGFB1, TGFB2, TGFB3
41growthGO:00400079.2BMP4, TGFB1, TGFB2, TGFB3
42positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.2BMP4, TGFB1, TGFB2, TGFB3
43transforming growth factor beta receptor signaling pathwayGO:00071799.2TGFB1, TGFB2, TGFB3
44SMAD protein signal transductionGO:00603959.2BMP4, TGFB1, TGFB2, TGFB3
45positive regulation of gene expressionGO:00106288.9BMP4, IL1A, TGFB1, TGFB2, TNC
46cell growthGO:00160498.7TGFB1, TGFB2, TGFB3
47wound healingGO:00420608.7BMP4, TGFB1, TGFB2, TGFB3
48negative regulation of cell proliferationGO:00082858.7BMP4, IL1A, TGFB1, TGFB2, TGFB3
49odontogenesisGO:00424768.5AQP1, AQP3, BMP4, TGFB2, TGFB3
50extracellular matrix organizationGO:00301987.5BMP4, FBN1, NID1, TGFB1, TGFB2, TGFB3

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor bindingGO:000516010.1BMP4, TGFB2
2type I transforming growth factor beta receptor bindingGO:00347139.8TGFB1, TGFB3
3type III transforming growth factor beta receptor bindingGO:00347149.5TGFB1, TGFB2, TGFB3
4type II transforming growth factor beta receptor bindingGO:00051149.5TGFB1, TGFB2, TGFB3
5water channel activityGO:00152509.2AQP1, AQP3, MIP
6glycerol channel activityGO:00152549.2AQP1, AQP3, MIP
7growth factor activityGO:00080838.6BMP4, TGFB1, TGFB2, TGFB3
8cytokine activityGO:00051258.3BMP4, IL1A, TGFB1, TGFB2, TGFB3

Sources for Bullous Keratopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet