Aliases & Classifications for Bullous Keratopathy

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Aliases & Descriptions for Bullous Keratopathy:

Name: Bullous Keratopathy 11 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:11031
ICD1030 H18.1
SNOMED-CT62 193815002, 57207003
ICD9CM32 371.23
NCIt45 C26970

Summaries for Bullous Keratopathy

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Wikipedia:71 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

MalaCards based summary: Bullous Keratopathy is related to keratopathy and endotheliitis, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Related Diseases for Bullous Keratopathy

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Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1keratopathy10.9
2endotheliitis10.5
3geleophysic dysplasia 210.2FBN1, TGFB2
4thalassemia minor10.2TGFB2, TGFB3
5cataract10.2
6legionaire disease10.1TGFB2, TGFB3
7juvenile onset parkinson disease 19a10.1BMP2, BMP4
8intellectual developmental disorder with persistence of fetal hemoglobin10.1TGFB2, TGFB3
9renal tubular transport disease10.1TGFB2, TGFB3
10tarsal-carpal coalition syndrome10.1BMP2, BMP4
11multiple synostoses syndrome10.1BMP2, BMP4
12salt and pepper syndrome10.1BMP2, BMP4
13ceroid lipofuscinosis, neuronal, kufs type, adult onset10.1BMP2, FBN1, TNC
14discharging ear10.1TGFB2, TGFB3
15keratitis10.0
16fuchs' endothelial dystrophy10.0
17leber congenital amaurosis10.0TGFB3, TNC
18endemic typhus10.0FBN1, TGFB2, TGFB3
19tmem231-related meckel syndrome10.0FBN1, TGFB2, TGFB3
20microglandular adenosis of breast10.0CXCL8, IL1A
21autoimmune polyendocrine syndrome type 110.0CXCL8, TNC
22prediabetes syndrome10.0AQP3, MIP
23neuropathy, hereditary sensory and autonomic, type vi10.0BMP4, FBN1
24t cell immunodeficiency primary10.0BMP2, BMP4, TGFB3
25keratoconus9.9
26corneal disease9.9
27renovascular hypertension9.9CXCL8, IL1A
28astigmatism9.8
29herpes simplex9.8
30classic type lipoma9.8BMP2, CXCL8, IL1A
31limbal stem cell deficiency9.7BMP4, FBN1, IL1A, NID1, TNC
32aniridia9.7
33insulin-like growth factor i9.7
34acne9.7
35corneal endothelial dystrophy9.7
36open-angle glaucoma9.7
37corneal edema9.7
38myopia9.7
39corneal ulcer9.7
40refractive error9.7
41essential iris atrophy9.7
42contact lens corneal edema8.6AQP3, BMP2, BMP4, CXCL8, FBN1, IL1A

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Endothelial DystrophyCorneal Edema
Corneal DegenerationCorneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to bullous keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

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UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2AQP3, BMP2, BMP4, TGFB2, TNC
2MP:00053719.2BMP2, BMP4, FBN1, TGFB2, TGFB3
3MP:00053828.7AQP3, BMP2, BMP4, FBN1, TGFB2, TGFB3
4MP:00053857.8AQP3, BMP2, BMP4, FBN1, IL1A, NID1
5MP:00053917.7AQP3, BMP4, MIP, NID1, TGFB2, TGFB3

Drugs & Therapeutics for Bullous Keratopathy

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Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylprednisoloneapproved, vet_approvedPhase 2119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
Prednisoloneapproved, vet_approvedPhase 2119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
FluorometholoneapprovedPhase 220426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
 
Fluorometholone (JP15/USP/INN)
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml (TN)
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
4
Bevacizumabapproved, investigationalPhase 22020216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
5Pharmaceutical SolutionsPhase 28192
6Peripheral Nervous System AgentsPhase 223689
7Methylprednisolone HemisuccinatePhase 21193
8Neuroprotective AgentsPhase 21716
9Protective AgentsPhase 27443
10Prednisolone hemisuccinatePhase 21193
11Prednisolone acetatePhase 21193
12Methylprednisolone acetatePhase 21193
13AnestheticsPhase 29596
14Prednisolone phosphatePhase 21193
15Anti-Inflammatory AgentsPhase 210729
16AntiemeticsPhase 24022
17Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168
18Anti-Allergic AgentsPhase 21522
19Antineoplastic Agents, HormonalPhase 25592
20Autonomic AgentsPhase 210150
21HormonesPhase 214415
22Hormone AntagonistsPhase 213180
23glucocorticoidsPhase 25103
24Gastrointestinal AgentsPhase 28402
25MitogensPhase 21617
26Endothelial Growth FactorsPhase 2382
27Angiogenesis Modulating AgentsPhase 24185
28Angiogenesis InhibitorsPhase 24257
29
Folic Acidapproved, nutraceutical, vet_approved439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
30
Riboflavinapproved, nutraceutical, vet_approved17483-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
E101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
 
Hyre
Lactobene
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
31Anti-Bacterial Agents11226
32Alkylating Agents4827
33Mitomycins240
34Nucleic Acid Synthesis Inhibitors4962
35Vitamins5282
36Antibiotics, Antitubercular7180
37Dermatologic Agents5806
38Micronutrients6001
39Photosensitizing Agents492
40Trace Elements6001
41Vitamin B Complex4337
42FolateNutraceutical4392
43Vitamin B2Nutraceutical174
44Vitamin B9Nutraceutical4392

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Amniotic Membrane Graft In Syntomathic Bullous KeratopathyCompletedNCT01926535Phase 2
2Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)CompletedNCT01448213Phase 2
3Pain and Visual Outcome in Intravitreal Bevacizumab InjectionEnrolling by invitationNCT02790775Phase 2
4Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture MediaUnknown statusNCT00623584
5Comparing Endoglide to Endoserter for DSAEK Graft InsertionUnknown statusNCT01791075
6Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal EdemaUnknown statusNCT01890252
7Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Unknown statusNCT02020044
8Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous KeratopathyCompletedNCT00659308
9The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous KeratopathyCompletedNCT01106274
10Automated Lamellar Keratectomy in Symptomatic Patients With Bullous KeratopathyCompletedNCT00654888
11The SNEC DSAEK EndoGlide Clinical TrialCompletedNCT01122043
12Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal EdemaRecruitingNCT02660151
13Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
14Corneal Transplantation Guided by OCT RESCANNot yet recruitingNCT02736877
15Topical Steroid Treatment After Posterior Lamellar Corneal TransplantationWithdrawnNCT01682421

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

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Anatomical Context for Bullous Keratopathy

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MalaCards organs/tissues related to Bullous Keratopathy:

36
Endothelial, Eye, Testes

Publications for Bullous Keratopathy

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Articles related to Bullous Keratopathy:

(show top 50)    (show all 254)
idTitleAuthorsYear
1
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. (27994806)
2016
2
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. (27462256)
2016
3
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. (27980363)
2016
4
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. (27648049)
2016
5
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. (27538190)
2016
6
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. (26880480)
2016
7
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. (26606297)
2016
8
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. (27820951)
2016
9
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. (25586624)
2015
10
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. (25609910)
2015
11
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. (26286755)
2015
12
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. (26509766)
2015
13
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. (26509077)
2015
14
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. (26555584)
2015
15
Case series and techniques of Descemet's Stripping Automated Endothelial Keratoplasty for severe bullous keratopathy after birth injury. (26245501)
2015
16
Anterior corneal surface irregularity after Descemet-stripping endothelial keratoplasty for bullous keratopathy. (26541104)
2015
17
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). (25959108)
2015
18
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. (26491241)
2015
19
Three-year outcome of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy. (24915015)
2014
20
Regeneration of corneal endothelial cells following keratoplasty in rats with bullous keratopathy. (24883013)
2014
21
Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs' Endothelial Dystrophy. (25484904)
2014
22
Use of amniotic membrane in bullous keratopathy palliative care. (25870682)
2014
23
Outcomes of corneal collagen crosslinking in pseudophakic bullous keratopathy. (24452209)
2014
24
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
25
Femtosecond laser-assisted intracorneal biopolymer insertion for the symptomatic treatment of bullous keratopathy. (24619170)
2014
26
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. (25627186)
2014
27
Superficial epithelial keratectomy, cautery, and amniotic membrane transplant for the treatment of painful bullous keratopathy in eyes with poor visual potential. (24815111)
2014
28
Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. (25088633)
2014
29
Alternatives to corneal transplantation for the management of bullous keratopathy. (24807064)
2014
30
Comparison of sulfur hexafluoride and air for donor attachment in Descemet stripping endothelial keratoplasty in patients with pseudophakic bullous keratopathy. (24452211)
2014
31
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. (23957427)
2013
32
Bullous keratopathy as a progressive disease: evidence from clinical and laboratory imaging studies. (24104939)
2013
33
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. (23861578)
2013
34
Complement activation in the aqueous humor of pseudophakic bullous keratopathy patients. (23258303)
2013
35
'Dirty Picture!-Pleasant outcome' - A two step approach to anterior staphyloma and bullous keratopathy. (24600153)
2013
36
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
37
Iridoschisis associated with nanophthalmos and bullous keratopathy. (23001742)
2013
38
Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty. (24066132)
2013
39
Descemet stripping automated endothelial keratoplasty for bullous keratopathy with an irregular posterior surface. (23846407)
2013
40
Combined scraping, coagulation, and subconjunctival bevacizumab in Descemet stripping automated endothelial keratoplasty for bullous keratopathy. (23161181)
2013
41
Management of bullous keratopathy-related ulcer with autologous serum. (22781466)
2013
42
Descemet stripping automated endothelial keratoplasty for bullous keratopathy after anterior-posterior radial keratotomy. (23770978)
2013
43
Endothelial keratoplasty for bullous keratopathy in eyes with an anterior chamber intraocular lens. (24286840)
2013
44
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
45
Comparison of treatments for bullous keratopathy in rabbits. (23737903)
2013
46
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
47
Role of corneal collagen cross-linking in pseudophakic bullous keratopathy: a clinicopathological study. (23953101)
2013
48
Amniotic membrane transplantation versus anterior stromal puncture in bullous keratopathy: a comparative study. (23723410)
2013
49
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. (22467587)
2012
50
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012

Variations for Bullous Keratopathy

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Expression for genes affiliated with Bullous Keratopathy

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Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for genes affiliated with Bullous Keratopathy

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Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathwaysScoreTop Affiliating Genes
19.6TGFB2, TGFB3
29.6TGFB2, TGFB3
39.6TGFB2, TGFB3
49.6BMP2, BMP4
59.6BMP2, BMP4
69.3TGFB2, TGFB3, TNC
7
Show member pathways
9.3TGFB2, TGFB3, TNC
8
Show member pathways
9.3IL1A, TGFB2, TGFB3
99.3IL1A, TGFB2, TGFB3
109.2BMP4, TGFB2, TGFB3
118.9BMP2, CXCL8, IL1A
128.8CXCL8, TGFB2, TGFB3
138.8CXCL8, TGFB2, TGFB3
148.8BMP2, BMP4, TGFB2, TGFB3
15
Show member pathways
8.8BMP2, BMP4, TGFB2, TGFB3
16
Show member pathways
8.8BMP2, BMP4, TGFB2, TGFB3
178.8BMP2, BMP4, TGFB2, TGFB3
188.8BMP2, BMP4, TGFB2, TGFB3
198.8BMP2, BMP4, TGFB2, TGFB3
20
Show member pathways
8.5BMP2, BMP4, FBN1, TGFB2, TGFB3
218.5CXCL8, IL1A, TGFB2, TGFB3
228.5CXCL8, IL1A, TGFB2, TGFB3
23
Show member pathways
8.4BMP2, BMP4, IL1A, TGFB2, TGFB3
24
Show member pathways
8.2AQP3, BMP2, BMP4, TGFB2, TGFB3
25
Show member pathways
8.2BMP2, BMP4, FBN1, TGFB2, TGFB3, TNC
267.9BMP2, BMP4, CXCL8, TGFB2, TGFB3
277.9BMP2, BMP4, CXCL8, IL1A, TGFB3
28
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
29
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
30
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
31
Show member pathways
7.6BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3
32
Show member pathways
7.6BMP2, BMP4, FBN1, NID1, TGFB2, TGFB3
33
Show member pathways
7.0BMP2, BMP4, CXCL8, FBN1, IL1A, TGFB2

GO Terms for genes affiliated with Bullous Keratopathy

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Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:000560410.1FBN1, NID1, TNC
2extracellular matrixGO:00310129.2FBN1, NID1, TGFB2, TGFB3, TNC
3proteinaceous extracellular matrixGO:00055788.9BMP4, FBN1, NID1, TNC
4extracellular regionGO:00055767.1BMP2, BMP4, CXCL8, FBN1, IL1A, NID1
5extracellular spaceGO:00056157.0BMP2, BMP4, CXCL8, FBN1, IL1A, NID1

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1cardiac right ventricle morphogenesisGO:000321510.5BMP4, TGFB2
2metanephros developmentGO:000165610.5BMP4, FBN1
3membranous septum morphogenesisGO:000314910.5BMP4, TGFB2
4neuron fate commitmentGO:004866310.5BMP4, TGFB2
5atrioventricular valve morphogenesisGO:000318110.5BMP2, TGFB2
6cardiac epithelial to mesenchymal transitionGO:006031710.5BMP2, TGFB2
7endocardial cushion morphogenesisGO:000320310.5BMP2, TGFB2
8outflow tract septum morphogenesisGO:000314810.5BMP4, TGFB2
9pharyngeal arch artery morphogenesisGO:006162610.5BMP4, TGFB2
10pathway-restricted SMAD protein phosphorylationGO:006038910.4BMP2, TGFB2
11pulmonary valve morphogenesisGO:000318410.4BMP4, TGFB2
12cell-cell junction organizationGO:004521610.4TGFB2, TGFB3
13face morphogenesisGO:006032510.4TGFB2, TGFB3
14BMP signaling pathway involved in heart inductionGO:000313010.4BMP2, BMP4
15cardiac muscle cell differentiationGO:005500710.4BMP2, BMP4
16cellular response to BMP stimulusGO:007177310.4BMP2, BMP4
17negative regulation of macrophage cytokine productionGO:001093610.4TGFB2, TGFB3
18mesenchymal cell proliferation involved in ureteric bud developmentGO:007213810.4BMP2, BMP4
19positive regulation of cartilage developmentGO:006103610.3BMP2, BMP4
20lung alveolus developmentGO:004828610.3BMP4, TGFB3
21positive regulation of pri-miRNA transcription from RNA polymerase II promoterGO:190289510.3BMP2, BMP4
22regulation of odontogenesis of dentin-containing toothGO:004248710.3BMP2, BMP4
23salivary gland morphogenesisGO:000743510.3TGFB2, TGFB3
24positive regulation of collagen biosynthetic processGO:003296710.2BMP4, TGFB3
25cellular protein metabolic processGO:004426710.2BMP4, FBN1, TNC
26SMAD protein import into nucleusGO:000718410.2TGFB2, TGFB3
27positive regulation of SMAD protein import into nucleusGO:006039110.2BMP4, TGFB3
28kidney developmentGO:000182210.2BMP4, FBN1, TGFB2
29uterine wall breakdownGO:004270410.2TGFB2, TGFB3
30telencephalon developmentGO:002153710.2BMP2, BMP4
31telencephalon regionalizationGO:002197810.1BMP2, BMP4
32water transportGO:000683310.1AQP3, MIP
33embryonic digestive tract developmentGO:004856610.1CXCL8, TGFB2
34odontogenesis of dentin-containing toothGO:004247510.0BMP2, BMP4, TNC
35osteoblast differentiationGO:000164910.0BMP2, BMP4, TNC
36negative regulation of gene expressionGO:001062910.0BMP2, BMP4, TGFB2
37positive regulation of cell divisionGO:005178110.0IL1A, TGFB2, TGFB3
38positive regulation of ossificationGO:004577810.0BMP2, BMP4, TGFB2
39positive regulation of protein secretionGO:005071410.0IL1A, TGFB2, TGFB3
40cell developmentGO:00484689.9BMP2, TGFB2, TGFB3
41inner ear developmentGO:00488399.9BMP2, TGFB2, TGFB3
42positive regulation of epithelial to mesenchymal transitionGO:00107189.9BMP2, TGFB2, TGFB3
43response to hypoxiaGO:00016669.8BMP2, TGFB2, TGFB3
44positive regulation of bone mineralizationGO:00305019.8BMP2, BMP4, TGFB3
45heart developmentGO:00075079.7BMP2, BMP4, FBN1, TGFB2
46extracellular matrix organizationGO:00301989.7FBN1, NID1, TGFB2, TNC
47skeletal system developmentGO:00015019.6BMP2, BMP4, FBN1, TGFB2
48BMP signaling pathwayGO:00305099.5BMP2, BMP4, TGFB2, TGFB3
49positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.4BMP2, BMP4, TGFB2, TGFB3
50odontogenesisGO:00424769.4AQP3, BMP4, TGFB2, TGFB3

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1BMP receptor bindingGO:007070010.3BMP2, BMP4
2co-receptor bindingGO:003970610.3BMP2, BMP4
3type II transforming growth factor beta receptor bindingGO:00051149.9TGFB2, TGFB3
4type III transforming growth factor beta receptor bindingGO:00347149.9TGFB2, TGFB3
5water channel activityGO:00152509.6AQP3, MIP
6growth factor activityGO:00080839.2BMP2, BMP4, TGFB2, TGFB3
7transforming growth factor beta receptor bindingGO:00051609.1BMP2, BMP4, TGFB2, TGFB3
8cytokine activityGO:00051258.2BMP2, BMP4, CXCL8, IL1A, TGFB2, TGFB3

Sources for Bullous Keratopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet