Aliases & Classifications for Bullous Keratopathy

MalaCards integrated aliases for Bullous Keratopathy:

Name: Bullous Keratopathy 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD10 33 H18.1
ICD9CM 35 371.23
NCIt 47 C26970
SNOMED-CT 64 193815002 57207003
UMLS 69 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to keratopathy and acromicric dysplasia, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Pharmaceutical Solutions and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related phenotypes are cardiovascular system and craniofacial

Wikipedia : 72 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 keratopathy 31.9 TGFB3 TNC
2 acromicric dysplasia 10.6 FBN1 TGFB2
3 endotheliitis 10.5
4 corneal dystrophy, fuchs endothelial, 6 10.4 BMP4 TGFB2
5 tgfbr2-related thoracic aortic aneurysms and aortic dissections 10.4 TGFB2 TGFB3
6 loeys-dietz syndrome 4 10.4 TGFB2 TGFB3
7 clear cell adenocarcinoma 10.4 TGFB2 TGFB3
8 gnas hyperfunction 10.4 TGFB2 TGFB3
9 ectopic cushing syndrome 10.3 BMP2 BMP4
10 strawberry gallbladder 10.3 TGFB2 TGFB3
11 humeroradial synostosis 10.3 BMP2 BMP4
12 acth-independent macronodular adrenal hyperplasia 10.3 BMP2 BMP4
13 prediabetes syndrome 10.2 AQP3 MIP
14 colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas 10.2 BMP2 BMP4
15 patent ductus arteriosus 2 10.2 BMP4 FBN1
16 short qt syndrome 10.2 BMP2 BMP4
17 cataract 10.2
18 bleeding disorder, platelet-type, 21 10.1 FBN1 TGFB2
19 twin-to-twin transfusion syndrome 10.1 TGFB2 TGFB3
20 epidemic typhus 10.1 FBN1 TGFB2 TGFB3
21 thoracic spinal canal and spinal cord meningioma 10.1 FBN1 TGFB2 TGFB3
22 osteopetrosis and infantile neuroaxonal dystrophy 10.1 BMP2 TGFB2
23 tuberculous salpingitis 10.1 CXCL8 TNC
24 fuchs' endothelial dystrophy 10.0
25 keratitis 10.0
26 lymph node palisaded myofibroblastoma 10.0 CXCL8 IL1A
27 leukemia 10.0 FBN1 NID1 TNC
28 granuloma inguinale 9.9 CXCL8 IL1A
29 keratoconus 9.9
30 corneal disease 9.9
31 syringobulbia 9.9 BMP2 BMP4 TGFB3
32 myofascial pain syndrome 9.9 CXCL8 IL1A
33 astigmatism 9.8
34 herpes simplex 9.8
35 primary congenital glaucoma 9.8 BMP2 BMP4 TGFB3
36 sclerosing cholangitis 9.8 CXCL8 IL1A
37 cervical benign neoplasm 9.7 BMP2 BMP4
38 corneal edema 9.7
39 myopia 9.7
40 corneal ulcer 9.7
41 refractive error 9.7
42 aniridia 9.7
43 essential iris atrophy 9.7
44 insulin-like growth factor i 9.7
45 acne 9.7
46 open-angle glaucoma 9.7
47 pleomorphic lipoma 9.6 BMP2 CXCL8 IL1A
48 idiopathic corneal edema 6.2 AQP3 BMP2 BMP4 CXCL8 FBN1 IL1A

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy, Autosomal Recessive Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 AQP3 BMP2 BMP4 FBN1 IL1A NID1
2 craniofacial MP:0005382 9.73 TGFB3 AQP3 BMP2 BMP4 FBN1 TGFB2
3 hearing/vestibular/ear MP:0005377 9.55 AQP3 BMP2 BMP4 TGFB2 TNC
4 limbs/digits/tail MP:0005371 9.35 BMP2 BMP4 FBN1 TGFB2 TGFB3
5 vision/eye MP:0005391 9.1 AQP3 BMP4 MIP NID1 TGFB2 TGFB3

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3,Phase 2
2 Ophthalmic Solutions Phase 3
3 Tetrahydrozoline Phase 3
4
Fluorometholone Approved Phase 2 426-13-1 9878
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Bevacizumab Approved, Investigational Phase 2 216974-75-3
8 Anesthetics Phase 2
9 Anti-Allergic Agents Phase 2
10 Antiemetics Phase 2
11 Anti-Inflammatory Agents Phase 2
12 Antineoplastic Agents, Hormonal Phase 2
13 Autonomic Agents Phase 2
14 Gastrointestinal Agents Phase 2
15 glucocorticoids Phase 2
16 Hormone Antagonists Phase 2
17 Hormones Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
19 Methylprednisolone acetate Phase 2
20 Methylprednisolone Hemisuccinate Phase 2
21 Neuroprotective Agents Phase 2
22 Peripheral Nervous System Agents Phase 2
23 Prednisolone acetate Phase 2
24 Prednisolone hemisuccinate Phase 2
25 Prednisolone phosphate Phase 2
26 Protective Agents Phase 2
27 Angiogenesis Inhibitors Phase 2
28 Angiogenesis Modulating Agents Phase 2
29 Endothelial Growth Factors Phase 2
30 Mitogens Phase 2
31
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
32
Riboflavin Approved, Nutraceutical, Vet_approved 83-88-5 493570
33 Dermatologic Agents
34 Micronutrients
35 Photosensitizing Agents
36 Trace Elements
37 Vitamin B Complex
38 Vitamins
39 Alkylating Agents
40 Anti-Bacterial Agents
41 Antibiotics, Antitubercular
42 Mitomycins
43 Nucleic Acid Synthesis Inhibitors
44 Folate Nutraceutical
45 Vitamin B2 Nutraceutical
46 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Not yet recruiting NCT03248037 Phase 3 Netarsudil;Placebo
2 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
3 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
4 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
5 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
6 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
7 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
8 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
9 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
10 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274
11 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Mitomycin
12 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
13 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Salt solution
14 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
15 Corneal Transplantation Guided by OCT RESCAN Not yet recruiting NCT02736877
16 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421 Weak steroid (Flurolon, Allergan);Potent steroid (Maxidex, Alcon)

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

39
Endothelial, Eye, Testes

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 254)
id Title Authors Year
1
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
2
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. ( 27538190 )
2016
3
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. ( 27648049 )
2016
4
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. ( 26880480 )
2016
5
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
6
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. ( 27462256 )
2016
7
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. ( 27980363 )
2016
8
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. ( 27820951 )
2016
9
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. ( 25586624 )
2015
10
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. ( 26491241 )
2015
11
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. ( 26509077 )
2015
12
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. ( 26555584 )
2015
13
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. ( 25609910 )
2015
14
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. ( 26286755 )
2015
15
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). ( 25959108 )
2015
16
Anterior corneal surface irregularity after Descemet-stripping endothelial keratoplasty for bullous keratopathy. ( 26541104 )
2015
17
Case series and techniques of Descemet's Stripping Automated Endothelial Keratoplasty for severe bullous keratopathy after birth injury. ( 26245501 )
2015
18
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. ( 26509766 )
2015
19
Three-year outcome of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy. ( 24915015 )
2014
20
Outcomes of corneal collagen crosslinking in pseudophakic bullous keratopathy. ( 24452209 )
2014
21
Superficial epithelial keratectomy, cautery, and amniotic membrane transplant for the treatment of painful bullous keratopathy in eyes with poor visual potential. ( 24815111 )
2014
22
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). ( 25015213 )
2014
23
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. ( 25627186 )
2014
24
Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs' Endothelial Dystrophy. ( 25484904 )
2014
25
Comparison of sulfur hexafluoride and air for donor attachment in Descemet stripping endothelial keratoplasty in patients with pseudophakic bullous keratopathy. ( 24452211 )
2014
26
Regeneration of corneal endothelial cells following keratoplasty in rats with bullous keratopathy. ( 24883013 )
2014
27
Use of amniotic membrane in bullous keratopathy palliative care. ( 25870682 )
2014
28
Alternatives to corneal transplantation for the management of bullous keratopathy. ( 24807064 )
2014
29
Femtosecond laser-assisted intracorneal biopolymer insertion for the symptomatic treatment of bullous keratopathy. ( 24619170 )
2014
30
Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. ( 25088633 )
2014
31
Management of bullous keratopathy-related ulcer with autologous serum. ( 22781466 )
2013
32
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. ( 24373539 )
2013
33
'Dirty Picture!-Pleasant outcome' - A two step approach to anterior staphyloma and bullous keratopathy. ( 24600153 )
2013
34
Combined scraping, coagulation, and subconjunctival bevacizumab in Descemet stripping automated endothelial keratoplasty for bullous keratopathy. ( 23161181 )
2013
35
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. ( 23974894 )
2013
36
Iridoschisis associated with nanophthalmos and bullous keratopathy. ( 23001742 )
2013
37
Non-Descemet's stripping automated endothelial keratoplasty for bullous keratopathy secondary to iridoschisis. ( 23861578 )
2013
38
Amniotic membrane transplantation versus anterior stromal puncture in bullous keratopathy: a comparative study. ( 23723410 )
2013
39
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. ( 23730105 )
2013
40
Descemet stripping automated endothelial keratoplasty for bullous keratopathy after anterior-posterior radial keratotomy. ( 23770978 )
2013
41
Bullous keratopathy as a progressive disease: evidence from clinical and laboratory imaging studies. ( 24104939 )
2013
42
Persistence of structural changes at the anterior cornea in bullous keratopathy patients after endothelial keratoplasty. ( 24066132 )
2013
43
Descemet stripping automated endothelial keratoplasty for bullous keratopathy with an irregular posterior surface. ( 23846407 )
2013
44
Comparison of treatments for bullous keratopathy in rabbits. ( 23737903 )
2013
45
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. ( 23957427 )
2013
46
Endothelial keratoplasty for bullous keratopathy in eyes with an anterior chamber intraocular lens. ( 24286840 )
2013
47
Complement activation in the aqueous humor of pseudophakic bullous keratopathy patients. ( 23258303 )
2013
48
Role of corneal collagen cross-linking in pseudophakic bullous keratopathy: a clinicopathological study. ( 23953101 )
2013
49
Histological evaluation of corneal scar formation in pseudophakic bullous keratopathy. ( 22720074 )
2012
50
Analysis of causes of bullous keratopathy in East China: a 10-year retrospective study. ( 21221627 )
2012

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2
2
Show member pathways
13.47 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
3
Show member pathways
13.35 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
4
Show member pathways
13.23 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
5
Show member pathways
13.1 AQP3 BMP2 BMP4 TGFB2 TGFB3
6
Show member pathways
13.09 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
7
Show member pathways
12.8 BMP2 BMP4 FBN1 TGFB2 TGFB3 TNC
8
Show member pathways
12.51 BMP2 BMP4 IL1A TGFB2 TGFB3
9 12.45 BMP2 BMP4 CXCL8 TGFB2 TGFB3
10
Show member pathways
12.3 BMP2 BMP4 TGFB2 TGFB3
11
Show member pathways
12.15 BMP2 BMP4 FBN1 NID1 TGFB2 TGFB3
12
Show member pathways
12.09 IL1A TGFB2 TGFB3
13 12.08 BMP4 TGFB2 TGFB3
14 12.07 IL1A TGFB2 TGFB3
15 11.97 BMP2 BMP4 TGFB2 TGFB3
16 11.89 BMP2 BMP4 TGFB2 TGFB3
17 11.81 BMP2 CXCL8 IL1A
18 11.75 CXCL8 TGFB2 TGFB3
19 11.7 CXCL8 IL1A TGFB2 TGFB3
20 11.69 TGFB2 TGFB3 TNC
21 11.65 BMP2 BMP4 TGFB2 TGFB3
22 11.58 BMP2 BMP4 TGFB2 TGFB3
23 11.58 CXCL8 IL1A TGFB2 TGFB3
24 11.48 BMP2 BMP4 TGFB2 TGFB3
25 11.47 TGFB2 TGFB3 TNC
26 11.39 CXCL8 TGFB2 TGFB3
27
Show member pathways
11.26 TGFB2 TGFB3
28 11.13 TGFB2 TGFB3
29 11.03 BMP2 BMP4
30 10.97 BMP2 BMP4
31 10.94 TGFB2 TGFB3
32
Show member pathways
10.88 BMP2 BMP4 FBN1 TGFB2 TGFB3
33 10.78 BMP2 BMP4 CXCL8 IL1A TGFB3
34 10.77 TGFB2 TGFB3

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.62 BMP4 FBN1 NID1 TNC
2 extracellular region GO:0005576 9.61 BMP2 BMP4 CXCL8 FBN1 IL1A NID1
3 extracellular matrix GO:0031012 9.55 FBN1 NID1 TGFB2 TGFB3 TNC
4 basement membrane GO:0005604 9.43 FBN1 NID1 TNC
5 extracellular space GO:0005615 9.28 BMP2 BMP4 CXCL8 FBN1 IL1A NID1

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 BMP2 BMP4 IL1A TNC
2 cellular protein metabolic process GO:0044267 9.88 BMP4 FBN1 TNC
3 heart development GO:0007507 9.88 BMP2 BMP4 FBN1 TGFB2
4 extracellular matrix organization GO:0030198 9.87 FBN1 NID1 TNC
5 response to hypoxia GO:0001666 9.86 BMP2 TGFB2 TGFB3
6 kidney development GO:0001822 9.82 BMP4 FBN1 TGFB2
7 osteoblast differentiation GO:0001649 9.81 BMP2 BMP4 TNC
8 wound healing GO:0042060 9.8 TGFB2 TGFB3 TNC
9 skeletal system development GO:0001501 9.8 BMP2 BMP4 FBN1 TGFB2
10 negative regulation of cell proliferation GO:0008285 9.8 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3
11 odontogenesis of dentin-containing tooth GO:0042475 9.74 BMP2 BMP4 TNC
12 inner ear development GO:0048839 9.73 BMP2 TGFB2 TGFB3
13 cell development GO:0048468 9.72 BMP2 TGFB2 TGFB3
14 epithelial to mesenchymal transition GO:0001837 9.71 BMP2 TGFB2
15 embryo development GO:0009790 9.71 BMP2 TGFB2
16 cellular response to BMP stimulus GO:0071773 9.71 BMP2 BMP4
17 positive regulation of cell division GO:0051781 9.71 IL1A TGFB2 TGFB3
18 BMP signaling pathway GO:0030509 9.71 BMP2 BMP4 TGFB2 TGFB3
19 lung alveolus development GO:0048286 9.7 BMP4 TGFB3
20 metanephros development GO:0001656 9.7 BMP4 FBN1
21 cardiac muscle cell differentiation GO:0055007 9.7 BMP2 BMP4
22 telencephalon development GO:0021537 9.69 BMP2 BMP4
23 outflow tract septum morphogenesis GO:0003148 9.69 BMP4 TGFB2
24 positive regulation of protein secretion GO:0050714 9.69 IL1A TGFB2 TGFB3
25 positive regulation of collagen biosynthetic process GO:0032967 9.68 BMP4 TGFB3
26 cell-cell junction organization GO:0045216 9.68 TGFB2 TGFB3
27 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.68 BMP2 BMP4
28 embryonic digestive tract development GO:0048566 9.68 CXCL8 TGFB2
29 water transport GO:0006833 9.67 AQP3 MIP
30 positive regulation of cartilage development GO:0061036 9.67 BMP2 BMP4
31 endocardial cushion morphogenesis GO:0003203 9.67 BMP2 TGFB2
32 pathway-restricted SMAD protein phosphorylation GO:0060389 9.66 BMP2 TGFB2
33 cardiac epithelial to mesenchymal transition GO:0060317 9.65 BMP2 TGFB2
34 cardiac right ventricle morphogenesis GO:0003215 9.65 BMP4 TGFB2
35 positive regulation of bone mineralization GO:0030501 9.65 BMP2 BMP4 TGFB3
36 positive regulation of SMAD protein import into nucleus GO:0060391 9.64 BMP4 TGFB3
37 atrioventricular valve morphogenesis GO:0003181 9.63 BMP2 TGFB2
38 pulmonary valve morphogenesis GO:0003184 9.62 BMP4 TGFB2
39 salivary gland morphogenesis GO:0007435 9.62 TGFB2 TGFB3
40 membranous septum morphogenesis GO:0003149 9.61 BMP4 TGFB2
41 telencephalon regionalization GO:0021978 9.61 BMP2 BMP4
42 pharyngeal arch artery morphogenesis GO:0061626 9.6 BMP4 TGFB2
43 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.59 BMP2 BMP4
44 negative regulation of macrophage cytokine production GO:0010936 9.58 TGFB2 TGFB3
45 SMAD protein signal transduction GO:0060395 9.56 BMP2 BMP4 TGFB2 TGFB3
46 positive regulation of ossification GO:0045778 9.54 BMP2 BMP4 TGFB2
47 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.52 BMP2 BMP4
48 uterine wall breakdown GO:0042704 9.46 TGFB2 TGFB3
49 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.46 BMP2 BMP4 TGFB2 TGFB3
50 BMP signaling pathway involved in heart induction GO:0003130 9.43 BMP2 BMP4

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 BMP2 BMP4 TGFB2 TGFB3
2 water channel activity GO:0015250 9.43 AQP3 MIP
3 co-receptor binding GO:0039706 9.4 BMP2 BMP4
4 BMP receptor binding GO:0070700 9.37 BMP2 BMP4
5 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFB3
6 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB2 TGFB3
7 transforming growth factor beta receptor binding GO:0005160 9.26 BMP2 BMP4 TGFB2 TGFB3
8 cytokine activity GO:0005125 9.1 BMP2 BMP4 CXCL8 IL1A TGFB2 TGFB3

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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