MCID: BLL006
MIFTS: 69

Bullous Pemphigoid malady

Rare diseases, Skin diseases, Immune diseases categories
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Summaries for Bullous Pemphigoid

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Bullous pemphigoid is a skin disorder characterized by large blisters. the blisters are usually located on the arms, legs, or middle of the body. about one-third of persons with bullous pemphigoid also develop blisters in the mouth. the blisters may break open and form ulcers or open sores. it usually occurs in elderly persons and is rare in young people. symptoms come and go. in most patients, the condition goes away within 6 years. the cause is not known, but may be related to immune system disorders. last updated: 4/28/2010

MalaCards: Bullous Pemphigoid, also known as pemphigoid, is related to pemphigus and epidermolysis bullosa, and has symptoms including negative nikolski's sign, immunodeficiency/increased susceptibility to infections/recurrent infections and psoriasis. An important gene associated with Bullous Pemphigoid is HLA-DRB1 (major histocompatibility complex, class II, DR beta 1), and among its related pathways are Cytokines and Inflammatory Response and Epstein-Barr virus infection. The drug sulfapyridine pwdr and the compounds glatiramer acetate and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:8 An autoimmune disease of skin and connective tissue characterized by large blisters.

Wikipedia:65 Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters,... more...

Aliases & Classifications for Bullous Pemphigoid

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Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases
Orphanet: 49 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

49
bullous pemphigoid:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

bullous pemphigoid 8 43 10 49 62
pemphigoid 8 43 47
senile dermatitis herpetiformis 43 62
benign pemphigus 43 62
pemphigoid, susceptibility to 9
pemphigoid bullous 45
old age pemphigus 43
pemphigoid nos 8
parapemphigus 43


External Ids:

Disease Ontology8 DOID:8506
MeSH35 D010391
ICD9CM27 694.5
MESH via Orphanet36 D010391
ICD10 via Orphanet26 L12.0
SNOMED-CT via Orphanet59 77090002
UMLS via Orphanet63 C0030805
ICD1025 L12, L12.0, L12.9

Related Diseases for Bullous Pemphigoid

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17GeneCards, 18GeneDecks
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Diseases related to Bullous Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1pemphigus31.5DST
2epidermolysis bullosa31.5ITGB4, DST, COL17A1, ITGA6
3cicatricial pemphigoid31.4COL17A1
4epidermolysis bullosa acquisita31.3COL17A1, ITGB4, LAD1, DST
5herpes gestationis31.1COL17A1, RNASE3, DST
6pemphigus foliaceus31.1DST, HLA-DRB1
7dermatitis herpetiformis31.1HLA-DQB1, CCL11
8pemphigus vulgaris31.0FCER2, DST, CCL11, HLA-DRB1
9psoriasis30.9IL5, CCL11, RNASE3, DST, SERPINF2, FCER2
10lichen planus30.8COL17A1, DST
11skin disease30.8HLA-DRB1
12junctional epidermolysis bullosa30.7COL17A1, ITGB4, ITGA6, DST
13epidermolysis bullosa simplex30.6DST, ITGB4, COL17A1
14ocular cicatricial pemphigoid30.5ITGB4, ITGA6
15pneumonia30.4CCL11, IL5
16conjunctivitis30.3RNASE3
17rheumatoid arthritis30.3HLA-DQB1, HLA-DRB1, FCER2, CCL11, RNASE3
18eosinophilia30.3CCL13, IL5, CCL11, CCL26, RNASE3, FCER2
19bullous skin disease30.3COL17A1, IL5, DST
20churg-strauss syndrome30.3IL5, RNASE3
21multiple sclerosis30.3CCL11, HLA-DQB1, HLA-DRB1, IL5
22esophagitis30.2CCL26, IL5, CCL11
23chronic eosinophilic pneumonia30.2IL5, CCL11, RNASE3
24eosinophilic pneumonia30.2IL5, RNASE3, CCL11
25hypereosinophilic syndrome30.2RNASE3, CCL11, IL5
26ulcerative colitis30.1CCL11, RNASE3, HLA-DRB1
27type 1 diabetes mellitus30.1HLA-DRB1, HLA-DQB1, CCL11
28sarcoidosis30.0CCL11, HLA-DRB1, HLA-DQB1, FCER2
29atopic dermatitis30.0ITGA6, CCL13, CCL11, FCER2, RNASE3, IL5
30leukemia29.9ITGA6, RNASE3, SERPINF2, HLA-DRB1, FCER2, CCL11
31keratoconjunctivitis29.8IL5, RNASE3, CCL11
32respiratory failure29.7RNASE3, CCL11
33dermatitis10.7
34neurologic diseases10.6
35burns10.5
36scabies10.5
37gingivitis10.5
38lupus erythematosus10.5
39pemphigoid gestationis10.5
40arthritis10.4
41lichen planus pemphigoides10.4
42erythema multiforme10.3
43systemic lupus erythematosus10.3
44hepatitis10.3
45thyroiditis10.3
46hemophilia10.3
47acquired hemophilia10.3
48linear iga disease10.3
49mucous membrane pemphigoid10.3
50crohn's disease10.3

Graphical network of the top 20 diseases related to Bullous Pemphigoid:



Diseases related to bullous pemphigoid

Symptoms for Bullous Pemphigoid

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49Orphanet
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Symptoms:

49 (show all 12)
  • negative nikolski's sign
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • psoriasis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • autoimmunity/autoimmune reaction/autoantibodies
  • urticaria
  • eczema
  • enanthema/aphtosa/aphta/leukoplakia
  • diabetes mellitus

Drugs & Therapeutics for Bullous Pemphigoid

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bullous Pemphigoid

Search NIH Clinical Center for Bullous Pemphigoid

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Bullous Pemphigoid

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Anatomical Context for Bullous Pemphigoid

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33MalaCards
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MalaCards organs/tissues related to Bullous Pemphigoid:

33
Skin, T cells, Breast, B cells, Testes, Thyroid, Brain, Liver, Thymus, Lung, Endothelial, Colon, Prostate

Animal Models for Bullous Pemphigoid or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bullous Pemphigoid:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3IL5, ITGB4, ITGA6, DST, FCER2, HLA-DQB1
2MP:00053888.3IL5, ITGB4, ITGA6, CCL11, HLA-DQB1
3MP:00053877.3HLA-DQB1, FCER2, CCL11, ITGA6, ITGB4, IL5

Publications for Bullous Pemphigoid

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Sources:
52PubMed
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Articles related to Bullous Pemphigoid:

(show top 50)    (show all 777)
idTitleAuthorsYear
1
Bullous pemphigoid: associations and management guidelines: facts and controversies. (23806157)
2013
2
IL-17 expression in dermatitis herpetiformis and bullous pemphigoid. (23970818)
2013
3
Childhood bullous pemphigoid. (24413516)
2013
4
Whole body application of a potent topical corticosteroid for bullous pemphigoid. (23551654)
2013
5
Association of pemphigus and bullous pemphigoid with thyroid autoimmunity in Caucasian patients. (23522419)
2013
6
Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida. (23651418)
2013
7
A case report of bullous pemphigoid induced by dipeptidyl peptidase-4 inhibitors. (23426497)
2013
8
Perifollicular pigmentation in bullous pemphigoid: A diagnostic sign. (23130215)
2011
9
Chronic renal graft rejection-associated bullous pemphigoid: A cross-reactive immune response? (21088811)
2011
10
Acute zoster in known pemphigus vulgaris and bullous pemphigoid: avoiding the "disease flare" trap. (21571161)
2011
11
Bullous pemphigoid associated with chronic renal allograft rejection: resolution after transplantectomy. (21839308)
2011
12
Accuracy of indirect immunofluorescence on sodium chloride-split skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. (22016274)
2011
13
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. (21880713)
2011
14
Bullous pemphigoid in a patient with suspected non-Herlitz junctional epidermolysis bullosa. (20456391)
2010
15
Prevalence of autoantibodies to bullous pemphigoid antigens within the normal population. (20083697)
2010
16
Ecthyma-gangrenosum-like bullous pemphigoid. (20689254)
2010
17
Favourable progression of acquired hemophilia-associated bullous pemphigoid. (19451049)
2009
18
Utility of an interferon-gamma release assay for latent tuberculosis diagnosis in a case of bullous pemphigoid. (19769839)
2009
19
Medication history of a series of patients with bullous pemphigoid from northern Greece - observations and discussion. (19200186)
2009
20
Searching for foreign antigens as possible triggering factors of autoimmunity: Torque Teno virus DNA prevalence is elevated in sera of patients with bullous pemphigoid. (18400063)
2008
21
Localized flexural bullous pemphigoid. (19882021)
2008
22
Childhood bullous pemphigoid in association with hyperimmunoglobulin E syndrome. (18304149)
2008
23
A new approach on bullous pemphigoid therapy. (18325915)
2008
24
Fatal bullous pemphigoid unresponsive to any therapeutic regimens. (17243967)
2007
25
Serum chemokine profile in patients with bullous pemphigoid. (17300233)
2007
26
Bullous pemphigoid associated with hypereosinophilic syndrome: simultaneous response to imatinib. (17097375)
2007
27
Furosemide-induced bullous pemphigoid: case report and review of literature. (16774111)
2006
28
Bullous pemphigoid initially localized around a urostomy. (17076741)
2006
29
Bullous pemphigoid after liver transplantation for liver failure. (17058253)
2006
30
Radiation therapy as a trigger factor for initially localized bullous pemphigoid. (16297104)
2005
31
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid. (15538734)
2004
32
T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis. (15451475)
2004
33
Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies. (12603849)
2003
34
Anti-glomerular basement membrane nephritis and bullous pemphigoid caused by distinct anti-alpha 3(IV)NC1 and anti-BP180 antibodies in a patient with Crohn's disease. (12200819)
2002
35
Increased tryptase and myeloperoxidase levels in blister fluids of patients with bullous pemphigoid: correlations with cytokines, adhesion molecules and anti-basement membrane zone antibodies. (10772387)
2000
36
Increased serum levels of interleukin (IL)-5, IL-6 and IL-8 in bullous pemphigoid. (9459128)
1998
37
Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes. (9500991)
1998
38
180-kDa bullous pemphigoid antigen defective generalized atrophic benign epidermolysis bullosa: report of four cases with an unusually mild phenotype. (9666835)
1998
39
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. (9660880)
1998
40
Bullous pemphigoid in an HB virus carrier: interaction between corticosteroids and HB virus. (9114616)
1997
41
Study of epitopic sites of the major bullous pemphigoid antigen (BPAg1)]. (7574105)
1995
42
A case of bullous pemphigoid with antibodies against intercellular 130 kd antigen. (7560455)
1995
43
Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa. (7550320)
1995
44
Primary cutaneous blastomycosis: report of a case acquired by direct inoculation of a bullous pemphigoid lesion. (8040417)
1994
45
Bullous pemphigoid in a 19-year-old woman. A case with unusual target antigens. (8123579)
1994
46
IgG antibodies from patients with bullous pemphigoid bind to fusion proteins encoded by BPAg1 cDNA. (7504025)
1993
47
Granulocyte activation in bullous diseases: release of granular proteins in bullous pemphigoid and pemphigus vulgaris. (8393016)
1993
48
HD4, a 180 kDa bullous pemphigoid antigen, is a major transmembrane glycoprotein of the hemidesmosome. (8514739)
1993
49
Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments. (1390446)
1992
50
Direct immunofluorescence studies of sodium chloride-separated skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. (2180996)
1990

Variations for Bullous Pemphigoid

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Expression for genes affiliated with Bullous Pemphigoid

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bullous Pemphigoid

Search GEO for disease gene expression data for Bullous Pemphigoid.

Pathways for genes affiliated with Bullous Pemphigoid

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 55Reactome, 54R&D Systems, 60Thomson Reuters
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Pathways related to Bullous Pemphigoid according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL5, HLA-DRB1
29.6HLA-DQB1, HLA-DRB1, FCER2
39.5ITGA6, HLA-DRB1, HLA-DQB1
49.4COL17A1, ITGB4, ITGA6
59.2ITGB4, ITGA6, FCER2
6
Show member pathways
9.2HLA-DQB1, HLA-DRB1, ITGA6, ITGB4
7
Show member pathways
9.2HLA-DQB1, HLA-DRB1, ITGA6, IL5
8
Show member pathways
9.2DST, ITGA6, ITGB4, COL17A1
9
Show member pathways
9.2DST, ITGA6, ITGB4, COL17A1
10
Show member pathways
9.2DST, ITGA6, ITGB4, COL17A1
11
Show member pathways
9.2COL17A1, ITGB4, ITGA6, DST
129.0HLA-DRB1, FCER2, ITGA6, IL5
13
Show member pathways
9.0CCL13, CCL11, CCL26
14
Show member pathways
9.0CCL26, CCL11, CCL13
15
Show member pathways
8.8HLA-DQB1, HLA-DRB1, FCER2, ITGA6, ITGB4
16
Show member pathways
8.6IL5, CCL13, CCL11, CCL26
178.3IL5, CCL11, CCL26, FCER2, IGHG3
18
Show member pathways
8.2HLA-DQB1, HLA-DRB1, RNASE3, CCL11, IL5
19
Show member pathways
8.2FCER2, CCL26, CCL11, CCL13, IL5
20
Show member pathways
7.9CCL26, CCL11, CCL13, ITGA6, ITGB4, COL17A1
21
Show member pathways
7.8CCL26, CCL11, CCL13, ITGA6, ITGB4, IL5
22
Show member pathways
7.8CCL26, CCL11, CCL13, ITGA6, ITGB4, IL5
23
Show member pathways
7.5CCL26, CCL11, CCL13, ITGA6, ITGB4, IL5

Compounds for genes affiliated with Bullous Pemphigoid

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 51PharmGKB
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Compounds related to Bullous Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate45 1111.1IL5, HLA-DRB1
2mometasone furoate45 6110.9IL5, RNASE3
3levocabastine45 29 1111.9IL5, RNASE3
4kalinin459.8DST, ITGA6, ITGB4
5beclomethasone dipropionate459.8IL5, RNASE3
6toluene diisocyanate459.8IL5, RNASE3
7gliadin459.7HLA-DQB1, RNASE3
8praziquantel45 1110.7IL5, RNASE3
95-oxoete459.6IL5, CCL11
10roxithromycin45 29 1111.6CCL11, IL5
11nedocromil sodium459.5IL5, RNASE3, FCER2
12azelastine45 1110.5RNASE3, IL5
13ltd4459.5IL5, RNASE3
14anti-histamine459.3RNASE3, CCL11
15txb2459.3FCER2, SERPINF2, RNASE3
16glutamine459.2HLA-DQB1, FCER2, SERPINF2, IL5
17unicap459.1RNASE3, CCL11, IL5
18lte4459.1IL5, CCL11, RNASE3
19sodium cromoglycate459.1IL5, CCL11, RNASE3
20cetirizine45 29 24 1112.1IL5, CCL11, RNASE3
21pranlukast45 29 1111.1IL5, CCL11, RNASE3
22salmeterol45 51 29 1112.1RNASE3, CCL11, IL5
23ketotifen45 1110.1RNASE3, CCL11, IL5
24montelukast45 51 29 1112.1IL5, CCL11, RNASE3
25ltc4459.1RNASE3, CCL11, IL5
26budesonide45 51 1111.1RNASE3, CCL11, IL5
27fluticasone propionate45 51 61 1112.1IL5, CCL11, RNASE3
28pgd2459.1RNASE3, CCL11, IL5
29tarc459.1CCL26, CCL11, CCL13, IL5
30methacholine45 51 1111.0IL5, CCL11, RNASE3
31n-formylmethionyl-leucylphenylalanine459.0RNASE3, CCL11, IL5
32oligonucleotide459.0HLA-DQB1, HLA-DRB1, DST, RNASE3, ITGA6
33prednisolone45 29 1110.9IL5, CCL11, RNASE3
34herbimycin a45 619.8IL5, ITGA6, CCL11, FCER2
35salbutamol45 51 29 24 1112.7FCER2, RNASE3, CCL11, IL5
36leukotriene b445 61 2410.7FCER2, RNASE3, CCL11, IL5
37fmlp458.7FCER2, RNASE3, CCL11, IL5
38ionomycin458.6FCER2, CCL11, IL5
39allergens458.5IL5, CCL11, RNASE3, FCER2, HLA-DRB1
40pge2458.5IL5, CCL11, RNASE3, FCER2
41rantes458.4RNASE3, CCL26, CCL11, CCL13, IL5
42endotoxin458.4CCL11, RNASE3, SERPINF2
43histamine45 29 2410.4FCER2, RNASE3, CCL11, CCL13, IL5
44oxygen45 249.3SERPINF2, CCL26, CCL11, CCL13, ITGB4
45dexamethasone45 51 29 1111.3FCER2, RNASE3, CCL11, CCL13, IL5
46heparin45 29 24 1111.3SERPINF2, RNASE3, CCL11, IL5
47vegf458.0SERPINF2, RNASE3, CCL11, ITGA6, IL5
48retinoic acid45 248.8FCER2, RNASE3, CCL11, ITGA6, ITGB4, IL5
49tyrosine457.2HLA-DQB1, HLA-DRB1, FCER2, RNASE3, CCL11, ITGA6
50calcium45 51 24 1110.0FCER2, SERPINF2, DST, RNASE3, CCL26, CCL11

GO Terms for genes affiliated with Bullous Pemphigoid

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Sources:
16Gene Ontology
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Cellular components related to Bullous Pemphigoid according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.2HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:07155610.1HLA-DQB1, HLA-DRB1
3cell leading edgeGO:03125210.0ITGB4, DST
4clathrin-coated endocytic vesicle membraneGO:03066910.0HLA-DRB1, HLA-DQB1
5trans-Golgi network membraneGO:03258810.0HLA-DRB1, HLA-DQB1
6transport vesicle membraneGO:0306589.9HLA-DRB1, HLA-DQB1
7ER to Golgi transport vesicle membraneGO:0125079.7HLA-DRB1, HLA-DQB1
8basal plasma membraneGO:0099259.7DST, ITGA6, ITGB4
9external side of plasma membraneGO:0098979.5HLA-DRB1, FCER2, ITGA6
10hemidesmosomeGO:0300569.4COL17A1, ITGB4, ITGA6, DST
11basement membraneGO:0056049.1LAD1, DST, ITGA6, ITGB4, COL17A1
12extracellular spaceGO:0056158.0IGHG3, SERPINF2, CCL26, CCL11, CCL13, IL5
13extracellular regionGO:0055767.8IGHG3, SERPINF2, RNASE3, CCL11, IL5, COL17A1

Biological processes related to Bullous Pemphigoid according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.3HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00245510.2HLA-DQB1, HLA-DRB1
3cell motilityGO:04887010.0ITGB4, DST
4integrin-mediated signaling pathwayGO:0072299.7DST, ITGA6, ITGB4
5cell-matrix adhesionGO:0071609.7COL17A1, ITGB4, ITGA6
6cell junction assemblyGO:0343299.7ITGA6, ITGB4, COL17A1
7filopodium assemblyGO:0468479.6ITGA6, ITGB4
8eosinophil chemotaxisGO:0482459.5CCL11, CCL13
9hemidesmosome assemblyGO:0315819.5COL17A1, ITGB4, ITGA6, DST
10cytokine-mediated signaling pathwayGO:0192219.4IL5, HLA-DRB1, HLA-DQB1
11extracellular matrix organizationGO:0301989.4COL17A1, ITGB4, ITGA6, DST
12positive regulation of Rac GTPase activityGO:0328559.3CCL11, CCL26
13positive regulation of actin filament polymerizationGO:0308389.3CCL11, CCL26
14cytoskeleton organizationGO:0070109.2CCL13, CCL11, DST
15chemotaxisGO:0069359.1CCL26, CCL11, CCL13
16inflammatory responseGO:0069548.9IL5, CCL13, CCL11, CCL26
17immune responseGO:0069558.5HLA-DQB1, HLA-DRB1, CCL26, CCL11, CCL13, IL5

Molecular functions related to Bullous Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DRB1, HLA-DQB1
2integrin bindingGO:0051789.0ITGA6, DST, FCER2
3chemokine activityGO:0080098.9CCL13, CCL11, CCL26

Products for genes affiliated with Bullous Pemphigoid

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Sources for Bullous Pemphigoid

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet