Bullous Pemphigoid malady

NIH Rare Diseases: Bullous pemphigoid is a skin disorder characterized by large blisters. The blisters are usually located on the arms, legs, or middle of the body. About one-third of persons with bullous pemphigoid also develop blisters in the mouth. The blisters may break open and form ulcers or open sores. It usually occurs in elderly persons and is rare in young people. Symptoms come and go. In most patients, the condition goes away within 6 years. The cause is not known, but may be related to immune system disorders.³⁰

MalaCards: Bullous Pemphigoid, also known as pemphigoid, is related to cicatricial pemphigoid and herpes gestationis. An important gene associated with Bullous Pemphigoid is DST (dystonin), and among its related pathways are Cell adhesion molecules (CAMs) and UPA-UPAR Pathway. The drug sulfapyridine and the compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and skin, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology: An autoimmune disease of skin and connective tissue characterized by large blisters.⁶

Wikipedia: Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters,...⁴⁴ more...

Aliases & Descriptions:

bullous pemphigoid 6 30 8 43 pemphigoid 6 30 33 senile dermatitis herpetiformis 30 bullous pemphigoid (disorder) 6 pemphigoid nos (disorder) 6

pemphigoid (disorder) 6 pemphigoid bullous 32 old age pemphigus 30 benign pemphigus 30 parapemphigus 30

Diseases related to bullous pemphigoid by text searches and GeneDecks gene sharing:

(show top 50)    (show all 927)

id	Related Disease	Score	Top Affiliating Genes
1	cicatricial pemphigoid	35.4	LAD1, LAMA3, LAMC2, CD79A, ITGA6, ITGB4
2	herpes gestationis	34.8	CD79A, COL17A1, RNASE3, RNF103, DSG1, DST
3	epidermolysis bullosa	34.3	LAD1, LAMA3, LAMB3, LAMC2, CD79A, CD151
4	junctional epidermolysis bullosa	33.3	LAMA3, LAMB3, LAMC2, ITGA6, ITGB4, COL7A1
5	hailey-hailey disease	33.0	IVL, DSG1, DSG3, DSP
6	epidermolysis bullosa simplex	32.5	IVL, ITGB4, PLEC, COL7A1, COL17A1, KRT5
7	pemphigoid gestationis	32.3	CCL11, HLA-DRB1, COL17A1, DST
8	epidermolysis bullosa acquisita	31.1	LAD1, LAMA3, LAMC2, CD79A, ITGB4, ARFGEF1
9	scabies	30.7	CCL11, IGHE, DST, CSF3
10	b-cell lymphomas	30.6	CD22, CD40, ITGAL, ITGB1, FCER2, IL16
11	multiple sclerosis	28.8	CD40, IL1A, IL1B, IL1RN, IL4R, IFNG
12	squamous cell carcinoma	28.7	SELL, VEGFA, RAC1, LAMA3, LAMC2, CD151
13	tuberculosis	28.3	IL10, IL1B, IL1RN, IL4, CCL1, IFNG
14	ocular cicatricial pemphigoid	28.2	CD79A, ITGA6, ITGB4, MIF, IL4, IL5
15	pemphigus foliaceus	28.1	CD79A, CD40LG, CD40, IVL, IL10, IL1A
16	oral lichen planus	27.9	VCAM1, IL1A, CCL5, ICAM1, CXCR3
17	neurologic diseases	27.8	CD40, IL15, IL1A, IL1B, IL1RN, IL2
18	skin disease	27.5	SELE, SELL, LAD1, LAMA3, LAMB3, LAMC2
19	pemphigus	26.6	CD79A, CD40LG, CD40, IVL, ITGB4, FCER2
20	pemphigus vulgaris	26.3	CD79A, IVL, FCER2, IL10, IL15, IL1A
21	crohn's disease	25.6	MPO, IRF1, MIF, IL10, IL13, IL17A
22	eosinophilia	24.5	SELL, VCAM1, MPO, CD79A, FCER2, IL10
23	lichen planus	22.8	VEGFA, LPP, VCAM1, LAMC2, CD79A, IVL
24	nephritis	21.0	SELE, VEGFA, VCAM1, LAMA1, MPO, CD79A
25	glomerulonephritis	20.8	SERPINF2, VEGFA, VCAM1, LAMA3, MPO, CD79A
26	psoriasis	18.4	SELE, SELPLG, SERPINF2, VEGFA, VCAM1, MPO
27	carcinoma	16.5	SELE, SELL, SELPLG, SERPINF2, VEGFA, LPP
28	junctional epidermolysis bullosa, non-herlitz type	14.1	LAMB3, LAMC2, ITGB4, COL17A1
29	follicular dendritic cell sarcoma	14.0	FCER2, EVPL, PPL, DSG1, DSG3, DSP
30	dendritic cell sarcoma	14.0	FCER2, EVPL, PPL, DSG1, DSG3, DSP
31	paragonimiasis	14.0	IL5, CCL17, IGHE, RNASE3, CXCR3
32	pthirus pubis infestation	14.0	MIF, FCER2, IL5, CCL11, IGHE
33	chronic eosinophilic pneumonia	14.0	IL5, CCL11, RNASE3
34	eosinophilic gastroenteritis	14.0	IL5, CCL11, IGHE, RNASE3
35	junctional epidermolysis bullosa, herlitz type	14.0	LAMA3, LAMB3, LAMC2
36	lymphomatoid papulosis	14.0	CCR4, CCL17, CCR3, TNFRSF8, CXCR3
37	giant papillary conjunctivitis	14.0	IL5, CCL11, RNASE3
38	basal cell carcinoma	13.9	LAMC2, IVL, ITGB1, ITGB4, MMP13, COL17A1
39	helminthiasis	13.9	IL13, IL5, IGHE, RNASE3
40	epidermolysis bullosa with pyloric atresia	13.9	ITGA6, ITGB4, PLEC, ACHE
41	subcorneal pustular dermatosis	13.9	CD79A, DSG1, DSG3
42	contact dermatitis	13.9	IL1A, IL5, CCR4, IGHE, CXCL9, CXCR3
43	keratoacanthoma	13.8	IVL, MMP13, KRT14, AGTR1, DSG1, DSG3
44	keratoderma	13.8	EVPL, KRT5, KRT14, DSG1, DSP
45	fibrosis	13.8	SELE, SELL, SERPINF2, VEGFA, VCAM1, LMOD1
46	respiratory syncytial virus infectious disease	13.8	IRF1, IL13, IL5, CCL5
47	egg allergy	13.8	IL4, IL5, IGHE
48	aplasia cutis congenita	13.8	ITGA6, ITGB4, ACHE
49	b cell deficiency	13.8	CD79A, IL4, IL5, IGHE
50	allergic conjunctivitis	13.8	IL13, IL4, IL5, CCL11, IGHE, RNASE3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 sulfapyridine

MalaCards organs/tissues related to bullous pemphigoid:

²²

MGI Mouse Phenotypes related to bullous pemphigoid:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.5	DST, AGTR1, ITGB4, ITGB1, ITGA6, CD151
2	respiratory system phenotype	MP:0005388	10.3	ACHE, NFATC2, NFATC1, CCR4, MACF1, ITGB3
3	craniofacial phenotype	MP:0005382	10.2	ACHE, KRT5, NFATC2, NFATC1, COL7A1, IL17A
4	other phenotype	MP:0005395	9.8	CXCR3, DST, MACF1, IL2, IL13, IRF2
5	hematopoietic system phenotype	MP:0005397	9.6	HLA-DQA1, IGHE, CCR3, CCL11, CCR4, EN1
6	endocrine/exocrine gland phenotype	MP:0005379	9.5	IFNG, EN1, IL2RB, IL2, CD40LG, SELL
7	liver/biliary system phenotype	MP:0005370	9.1	NFATC1, IFNG, IL6, IL2, VEGFA
8	nervous system phenotype	MP:0003631	9.0	PLAU, PLAUR, NFATC2, RNF103, ACHE, TGFB1
9	limbs/digits/tail phenotype	MP:0005371	8.7	KRT5, NFATC1, COL7A1, ERBB2, EN1, IL10
10	skeleton phenotype	MP:0005390	8.5	ERBB2, NR3C1, PLAT, PLAU, COL7A1, NFATC1
11	digestive/alimentary phenotype	MP:0005381	8.4	NR3C1, PLAT, PLAU, COL7A1, NFATC1, KRT5
12	integument phenotype	MP:0010771	8.0	PLEC, NR3C1, ERBB2IP, ERBB2, EVPL, IFNG
13	normal phenotype	MP:0002873	8.0	IL4, EN1, CCL11, IFNG, HLA-DQB1, PPL
14	immune system phenotype	MP:0005387	7.9	IFNG, EN1, IL6, IL2, MIF, IRF1
15	growth/size phenotype	MP:0005378	7.4	PLAUR, PLAU, PLEC, PLAT, NR3C1, ERBB2
16	vision/eye phenotype	MP:0005391	7.3	TNF, PLAT, PLAU, NFATC2, KRT14, ACHE
17	muscle phenotype	MP:0005369	6.9	PLAT, PLEC, PLAU, PLAUR, NFATC2, ACHE
18	reproductive system phenotype	MP:0005389	6.8	IFNG, F8, ERBB2, TNF, COL17A1, KRT14
19	mortality/aging	MP:0010768	6.3	ATP6AP1, LAMC2, LAMB3, LAMA3, LAMA1, VCAM1
20	tumorigenesis	MP:0002006	6.3	IL6, IFNG, ICAM1, HP, ERBB2, TNF
21	behavior/neurological phenotype	MP:0005386	6.1	PLEC, PLAT, NR3C1, TNF, HLA-DQB1, PLAUR
22	homeostasis/metabolism phenotype	MP:0005376	5.8	MACF1, CD40LG, CD79A, MPO, RAC1, VCAM1
23	cardiovascular system phenotype	MP:0005385	4.6	HLA-DQB1, ERBB2, HP, ALOX5, ICAM1, IFNG
24	cellular phenotype	MP:0005384	3.8	CXCR3, TGFB1, DSP, DSG3, IFNG, CCL5

Articles related to bullous pemphigoid:

(show top 50)    (show all 261)

id	Title	Authors	Year	Affiliating Genes
1	Potential role of interleukin-17 in the pathogenesis of bullous pemphigoid. (19945799)	Toosi S.... Bystryn J.C.	2010	IL17A
2	C4d immunohistochemical stain is a sensitive method t o confirm immunoreactant deposition in formalin-fixed paraffin-embedded tissue in bullous pemphigoid. (19515044)	Chandler W.... Florell S.	2009	COL17A1
3	IgG from patients with bullous pemphigoid depletes cu ltured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII colla gen) and weakens cell attachment. (19177144)	Iwata H.... Kitajima Y.	2009	DST
4	Vitamin D(3) inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis. (18207369)	Yamamoto C.... Sawamura D.	2008	DST
5	Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. (17920818)	Ishiura N.... Tamaki K.	2008	COL17A1, DST
6	Oral steroid improves bullous pemphigoid-like clinical manifestations in non-Herlitz junctional epidermolysis bullosa with COL17A1 mutation. (17596158)	Mabuchi E.... Katayama I.	2007	COL17A1
7	Efficacy of interferon-gamma in patients with refractory bullous pemphigoid. (17973812)	Nakama T.... Hashimoto T.	2007	IL5
8	Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients (17121036)	Liu B.G.... Du M.	2006	NR3C1
9	Cytokine gene polymorphisms in bullous pemphigoid in a Chinese population. (16403098)	Chang Y.T.... Tsai S.F.	2006	TNF, IL6, IL1B
10	Interleukin-16 expression and release in bullous pemphigoid. (15320912)	Frezzolini A.... De PitA O.	2004	IL16
11	Genetic variation in COL17A1 and the development of bullous pemphigoid. (14987253)	Winsey S.... Wojnarowska F.	2004	COL17A1
12	Bullous pemphigoid in a leg affected with hemiparesia: a possible relation of neurological diseases with bullous pemphigoid? (11358730)	Foureur N.... Crickx B.	2001	DST
13	Autoantibodies to the extracellular and intracellular domain of bullous pemphigoid 180, the putative key autoantigen in bullous pemphigoid, belong predominantly to the IgG1 and IgG4 subclasses. (11298534)	Laffitte E.... Borradori L.	2001	COL17A1
14	Clinical significance of enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid. (11323216)	Amo Y.... Hashimoto T.	2001	COL17A1, DST
15	Cicatricial pemphigoid with circulating autoantibodies to beta4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230. (11899157)	Leverkus M.... Zillikens D.	2001	ITGB4
16	Bullous pemphigoid: interaction of interleukin 5, anti-basement membrane zone antibodies and eosinophils. A preliminary observation. . (11145840)	Engineer L.... Razzaque Ahmed A .	2001	IL5
17	Bullous pemphigoid of childhood: autoantibodies target the same epitopes within the NC16A domain of BP180 as autoantibodies in bullous pemphigoid of adulthood. (10768652)	Chimanovitch I.... Zillikens D.	2000	COL17A1
18	Molecular cloning of canine bullous pemphigoid antigen 2 cDNA and immunomapping of NC16A domain by canine bullous pemphigoid autoantibodies. (10564722)	Xu L.... Chan L.S.	2000	COL17A1
19	IgG and IgA antibodies in linear IgA/IgG bullous dermatosis target the ectodomain of bullous pemphigoid antigen 2. (10233336)	Hertl M.... Borradori L.	1999	COL17A1
20	Antibody to bullous pemphigoid antigen 1 binds to the antigen at perilesional but not uninvolved skin, in localized bullous pemphigoid. (9920986)	Seishima M.... Kitajima Y.	1999	DST
21	Demonstration of antibody to 230 kDa bullous pemphigoid antigen in lichen planus-like keratosis. (10417446)	Seishima M.... Kitajima Y.	1999	DST
22	Bullous pemphigoid sera that contain antibodies to BPAg2 also contain antibodies to LABD97 that recognize epitopes distal to the NC16A domain. (9989788)	Egan C.A.... Zone J.J.	1999	COL17A1
23	Bullous pemphigoid associated with Shy-Drager syndrome. (9714981)	Okazaki A.... Takayanagi T.	1998	DST
24	Internalization of the 180 kDa bullous pemphigoid antigen as immune complexes in basal keratinocytes: an important early event in blister formation in bullous pemphigoid. (9536225)	Kitajima Y.... Owaribe K.	1998	COL17A1, DST
25	Application of confocal laser scanning microscopy to differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. (9640362)	Kazama T.... Ito M.	1998	ITGB4
26	Immunofluorescence-negative bullous pemphigoid sera contain antibodies mostly directed against the 180 kDa bullous pemphigoid antigen (BPAg2) (9292090)	Ghohestani R.F.... Claudy A.	1997	COL17A1
27	T-helper 2 involvement in the pathogenesis of bullous pemphigoid: role of soluble CD30 (sCD30). (9452886)	De PitA! O.... Puddu P.	1997	IL2, TNFRSF8, FCER2
28	The majority of bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain of the 180-kDa bullous pemphigoid antigen. (8874743)	Matsumura K.... Hashimoto T.	1996	COL17A1, DST
29	IgE autoantibodies directed against the major bullous pemphigoid antigen in patients with a severe form of pemphigoid. (8871665)	Delaporte E.... Capron M.	1996	IGHE
30	Clinical manifestations in 100 Japanese bullous pemphigoid cases in relation to autoantigen profiles. (8689764)	Tanaka M.... Nishikawa T.	1996	COL17A1
31	Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant. (8949441)	Kawachi Y.... Otsuka F.	1996	DST
32	Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa. (7550320)	McGrath J.A.... Uitto J.	1995	LAMB3, LAMA3, COL17A1
33	In situ-bound antibodies eluted from the skin of patients with bullous pemphigoid are preferentially directed against the 230-kD bullous pemphigoid antigen. (7490478)	Korman N.J.	1995	DST
34	180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa. (7883981)	Jonkman M.F.... Sonnenberg A.	1995	COL17A1
35	Antibody-binding to the 180-kD bullous pemphigoid antigens at the lateral cell surface causes their internalization and inhibits their assembly at the basal cell surface in cultured keratinocytes. (7852645)	Kitajima Y.... Yaoita H.	1994	DST
36	A case of bullous pemphigoid with antidesmoplakin autoantibodies. (7999603)	Hashimoto T.... Nishikawa T.	1994	DSP
37	Molecular biology of the 230-kD bullous pemphigoid an tigen. Cloning of the BPAG1 gene and its tissue-specific expression. (8049559)	Tamai K.... Uitto J.	1994	DST
38	IgG antibodies from patients with bullous pemphigoid bind to fusion proteins encoded by BPAg1 cDNA. (7504025)	Miller J.E.... Hall R.P.	1993	DST
39	Localized bullous pemphigoid: report of a case with an immunofluorescence and electron microscopical studies on the lesional distribution of 180-KD bullous pemphigoid antigen, beta 4 integrin, and type VII collagen. (8408921)	Kitajima Y.... Yaoita H.	1993	ITGB4
40	Comparative study of bullous pemphigoid antigens among Japanese, British, and U.S. patients indicates similar antigen profiles with the 170-kD antigen present both in the basement membrane and on the keratinocyte cell membrane. (7681090)	Hashimoto T.... Nishikawa T.	1993	DST
41	IgE and its related phenomena in bullous pemphigoid. (8494749)	Soh H.... Asada Y.	1993	IGHE
42	The human 230-kD bullous pemphigoid antigen gene (BPA G1). Exon-intron organization and identification of regulatory tissue specific elements in the promoter region. (8349819)	Tamai K.... Uitto J.	1993	DST, GLYAT
43	Cloning of the 5' mRNA for the 230-kD bullous pemphigoid antigen by rapid amplification of cDNA ends. (8345227)	Elgart G.W.... Stanley J.R.	1993	DST
44	Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1) bind only to the intracellular domain of the hemidesmosome, whereas those against the 180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the hemidesmosome in normal human and swine skin. (7682575)	Ishiko A.... Nishikawa T.	1993	COL17A1, DST
45	Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments. (1390446)	Green K.J.... Parry D.A.	1992	DSP, DST
46	Cytoplasmic domain of the 180-kD bullous pemphigoid a ntigen, a hemidesmosomal component: molecular and cell biologic characterizatio n. (1512461)	Hopkinson S.B.... Jones J.C.	1992	COL17A1
47	Phorbol ester- and calcium-induced reorganization of 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy. (1426040)	Kitajima Y.... Yaoita H.	1992	DST
48	Cicatricial pemphigoid antigen differs from bullous pemphigoid antigen by its exclusive extracellular localization: a study by indirect immunoelectronmicroscopy. (2056190)	Bedane C.... Dubertret L.	1991	DST
49	Coexistence of pemphigus foliaceus and bullous pemphigoid. Demonstration of autoantibodies that bind to both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen. (1998370)	Korman N.J.... Woodley D.T.	1991	DST
50	Partial cDNA cloning of the 230-kD mouse bullous pemphigoid antigen by use of a human monoclonal anti-basement membrane zone antibody. (2200830)	Amagai M.... Nishikawa T.	1990	DST

Genes related to bullous pemphigoid according to GeneCards:

(show top 50)    (show all 120)

id	Symbol	Description	Score	GeneCards Section Context
1	DST	dystonin	11.1	Publications, Aliases & Descriptions, Orthologs
2	COL17A1	collagen, type XVII, alpha 1	11.1	Orthologs, Aliases & Descriptions, Publications
3	IGHG3	immunoglobulin heavy constant gamma 3 (G3m marker)	11.0	Publications
4	LAD1	ladinin 1	11.0	Publications
5	TMIGD2	transmembrane and immunoglobulin domain containing 2	11.0	Disorders
6	ITGB4	integrin, beta 4	11.0	Publications
7	RNF103	ring finger protein 103	11.0
8	EN1	engrailed homeobox 1	11.0	Publications
9	EVPL	envoplakin	11.0	Publications
10	GLYAT	glycine-N-acyltransferase	11.0	Publications
11	ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	11.0
12	DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	11.0
13	SASS6	spindle assembly 6 homolog (C. elegans)	11.0	Orthologs
14	CCL8	chemokine (C-C motif) ligand 8	11.0	Publications
15	CCL1	chemokine (C-C motif) ligand 1	11.0	Publications
16	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
17	CCL13	chemokine (C-C motif) ligand 13	11.0	Publications
18	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
19	CD151	CD151 molecule (Raph blood group)	11.0	Publications
20	CD22	CD22 molecule	11.0	Publications
21	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
22	PITRM1	pitrilysin metallopeptidase 1	11.0	Publications
23	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
24	LMOD1	leiomodin 1 (smooth muscle)	11.0	Publications
25	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
26	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
27	RHCE	Rh blood group, CcEe antigens	11.0	Publications
28	ITGA6	integrin, alpha 6	11.0	Publications
29	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
30	LAMC2	laminin, gamma 2	11.0	Publications
31	LAMB3	laminin, beta 3	11.0	Publications
32	OSM	oncostatin M	11.0	Publications
33	DHDDS	dehydrodolichyl diphosphate synthase	11.0
34	DSG3	desmoglein 3	11.0	Publications
35	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
36	PPL	periplakin	11.0	Publications
37	IVL	involucrin	11.0	Publications
38	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
39	IRF2	interferon regulatory factor 2	11.0	Publications
40	IRF1	interferon regulatory factor 1	11.0	Publications
41	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
42	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
43	KRT14	keratin 14	11.0	Publications
44	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
45	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
46	KRT5	keratin 5	11.0	Publications
47	SELL	selectin L	11.0	Publications
48	SELPLG	selectin P ligand	11.0	Publications
49	DSG1	desmoglein 1	11.0	Publications
50	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications

Pathways related to bullous pemphigoid according to GeneDecks:

(show top 50)    (show all 150)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.5	ITGB1, ITGAL, ITGA6, CD40, CD22, SELPLG
2	UPA-UPAR Pathway36	10.1	ITGB3, PLAU, COL17A1, MMP13, ITGB4, ITGB1
3	RAR-Gamma-RXR-Alpha Degradation36	9.6	IL15, IL16, IL2, IL3, IL7, CCL8
4	Cell adhesion_ECM remodeling41	9.5	ITGB1, LAMA1, PLAU, PLAT, LAMA3, PLAUR
5	NFAT Signaling and Lymphocyte Interactions36	9.5	CCL11, CCL26, CCL8, IL7, IL5, IL4
6	Transendothelial Migration of Leukocytes36	9.4	COL7A1, ITGB3, ITGB1, ITGAL, ITGA6, LAMC2
7	Immune System38	9.3	IRF2, IRF1, IFNG, ICAM1, IL5, IL3
8	ILK Signaling36	9.3	LAMC2, LAMA3, LAMA1, RAC1, KRT18, DSP
9	Jak-STAT signaling pathway20	9.1	IL15, IL10, IL13, IL3, IL4, IL5
10	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	IL1B, TGFB1, IL6, IL5, IL4R, IL4
11	Regulation of eIF4 and p70S6K36	9.0	TNFSF13B, IL16, IL15, IL13, ITGB3, ITGB1
12	IL-6 Pathway36	9.0	CCL8, IL8, IL7, IL5, IL4, IL3
13	Phospholipase-C Pathway36	8.9	RAC1, IL3, IL2, ITGB4, ITGB3, ITGB1
14	Staphylococcus aureus infection20	8.8	FCGR2A, HLA-DQB1, DSG1, HLA-DRB1, SELPLG, ITGAL
15	JNK Pathway36	8.8	IL6, TGFB1, IL4R, IL3, IL2RB, RAC1
16	Molecular Mechanisms of Cancer36	8.8	COL7A1, TNFSF13B, TNFRSF8, CCL5, CCL13, CCR3
17	Akt Signaling36	8.5	CCL17, IL10, ITGB4, ITGAL, ITGA6, IL15
18	PGC1Alpha Pathway36	8.4	TNFSF13B, CCL5, CCL13, CCL1, CCL17, CCL11
19	Asthma20	8.3	RNASE3, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, CCL11
20	Immune response_MIF-mediated glucocorticoid regulation41	8.3	VCAM1, MIF, IL8, TNF, ICAM1, IFNG
21	Immune response MIF-mediated glucocorticoid regulation10	8.3	MIF, VCAM1, IL2, NR3C1, TNF, ICAM1
22	Hematopoietic cell lineage20	8.0	ITGA6, CD22, ITGB3, FCER2, CSF3, TNF
23	SOCS Pathway36	7.8	IL7, IL6, IL5, IL4, IL3, IL2
24	Intestinal immune network for IgA production20	7.8	HLA-DQA1, IL6, IL5, IL4, IL2, IL15
25	Toxoplasmosis20	7.7	TGFB1, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, ALOX5
26	MAPK Signaling36	7.7	IL2, IL1B, TNF, IL1A, IL3, IL6
27	Allograft rejection20	7.7	HLA-DQA1, IL2, HLA-DQB1, HLA-DRB1, IFNG, IL5
28	TGF-Beta Pathway36	7.5	TGFB1, TNFSF13B, CCL5, CCL13, IL2, IL1B
29	THC Differentiation Pathway36	7.4	IL4, TNF, HLA-DRB1, HLA-DQB1, IL4R, IL2
30	Endothelin-1 Signaling Pathway36	7.4	CCL8, IL7, IL6, IL5, IL4, IL3
31	Leishmaniasis20	7.4	TGFB1, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG
32	Glucocorticoid Receptor Signaling36	7.3	TNFSF13B, IL3, IL2RB, IL2, IL1B, IL1A
33	Cytokine Network36	7.2	TNF, IL10, IL13, IFNG, IL8, IL6
34	PEDF Induced Signaling36	7.2	CCL26, CCL11, CCL17, CCL1, CCL13, CCL5
35	MIF Regulation of Innate Immune Cells36	7.1	CSF3, IL1B, IL1A, IL16, IL15, IL13
36	Malaria20	7.1	IFNG, IL8, IL6, IL1B, IL10, ITGAL
37	MAPK Family Pathway36	7.1	TGFB1, TNFSF13B, TNF, CCL5, CCL13, CCL1
38	all-trans-Retinoic Acid Signaling in Brain36	7.1	OSM, TNFSF13B, TNF, ALOX5, CCL5, CCL13
39	MIF Mediated Glucocorticoid Regulation36	7.1	IL15, IL13, IL10, MIF, IL5, IL16
40	Tec Kinases Signaling36	7.1	CCL13, IL3, IL2RB, IL2, IL16, IL15
41	STAT3 Pathway36	6.9	CCL5, IL4, IL3, IL2RB, IL2, IL1B
42	Tuberculosis20	6.9	FCGR3A, HLA-DRB1, HLA-DQB1, IL10, IL1A, IL1B
43	PAK Pathway36	6.9	CSF3, CCL13, IL1A, CCL5, TNF, TNFSF13B
44	ERK Signaling36	6.8	ITGA6, LAMC2, LAMB3, LAMA3, LAMA1, CSF3
45	Rheumatoid arthritis20	6.7	TGFB1, IL15, ITGAL, ATP6AP1, VEGFA, IL17A
46	Antioxidant Action of Vitamin-C36	6.6	CCL17, CCL11, CCR4, CCL26, CCL8, IL8
47	Rho Family GTPases36	6.6	CSF3, CXCL9, OSM, IL7, IL4, IL3
48	JAK-STAT Pathway36	6.1	TGFB1, AGTR1, TNFSF13B, ERBB2, IFNG, CCL5
49	p38 Signaling36	6.0	CCL11, IL1A, IL16, IL15, IL1B, IL2
50	Cytokine-cytokine receptor interaction20	5.7	CSF3, CXCR3, CXCL9, OSM, TGFB1, TNFSF13B

Compounds related to bullous pemphigoid according to GeneDecks:

(show top 50)    (show all 401)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	ITGAL, F8, CXCL9
2	ivig32	10.2	FCGR3A, IL1RAPL2, IL3, F8, DSG1, DSG3
3	hyaluronic acid32 18	11.1	RAC1, ITGAL, MMP13, IL13, GPT, PLAUR
4	methylcellulose32	9.8	IVL, IL15, IL1A, IL3, IL4, IL5
5	n-formylmethionyl-leucylphenylalanine32	9.4	SELL, SELPLG, MPO, ITGAL, FCGR3B, IL1A
6	nedocromil sodium32	9.1	FCER2, IL3, IL4, IL5, IL8, IGHE
7	polysaccharide32	9.1	SELE, SELL, SELPLG, SERPINF2, VCAM1, CD79A
8	epinephrine32 9 18 9	12.1	SELE, SELL, SERPINF2, CD79A, FCGR2A, IL1A
9	rituximab32 34 9 9	12.1	CD79A, CD40LG, CD40, FCGR2A, FCGR3A, FCGR3B
10	pge232	9.0	SELE, VCAM1, RAC1, IVL, MMP13, IRF1
11	n acetylcysteine32	9.0	SELE, VCAM1, CD79A, CD40, IL2RB, IL3
12	estrogen32	8.9	LMOD1, IVL, ITGB3, MMP13, MIF, IL1RN
13	cysteine32	8.8	SELPLG, LMOD1, RAC1, CD79A, CD40LG, CD40
14	methacholine32 9 9	10.7	MPO, CD79A, IL13, IL17A, IL2RB, IL4
15	h2o232	8.7	SELL, MPO, CD79A, CD40, ITGAL, MIF
16	groalpha32	8.5	SELE, VCAM1, MMP13, IL10, IL13, IL17A
17	calcium32 9 18 9	11.3	SELPLG, SERPINF2, RAC1, ATP6AP1, MPO, CD40
18	adalimumab32 9 9	10.1	CD79A, FCGR2A, FCGR3A, FCGR3B, IL10, IL1RAPL2
19	creatinine32	8.0	SELE, SELL, MPO, CD79A, CD40LG, CD40
20	lipid32	7.9	SELE, SELPLG, SERPINF2, VCAM1, RAC1, CD40
21	allergens32	7.8	CD79A, CD40LG, CD40, IVL, ITGAL, FCER2
22	polyinosinic-polycytidylic acid32	7.8	SELE, VCAM1, CD40, IRF1, IL10, IL15
23	mip 1alpha32	7.8	IL10, IL13, IL1B, IL3, IL4, IL6
24	poly(i-c)32	7.8	VCAM1, IRF1, IL15, IL1B, IL3, IL4
25	fluticasone propionate32 42 9 9	10.7	SELE, VCAM1, MPO, IL13, IL16, IL1B
26	superoxide32 18	8.5	SELL, VCAM1, RAC1, MPO, CD40, ITGAL
27	fibrinogen32	7.5	SELE, SELPLG, SERPINF2, VCAM1, RAC1, CD79A
28	pd 98,05932	7.5	VCAM1, RAC1, CD40, IVL, ITGA6, ITGB1
29	tgf beta132	7.5	VCAM1, MMP13, IL10, IL13, IL15, IL1B
30	leukotriene b432 42 18	9.4	SELL, RAC1, MPO, ITGAL, FCER2, FCGR3B
31	gold sodium thiomalate32	7.4	SELE, IL1A, IL1B, IL1RN, IL2, IL8
32	pdtc32	7.3	SELE, VCAM1, CD40, IRF1, FCER2, IL1A
33	histamine32 18	8.2	SELE, SELL, SELPLG, VCAM1, MPO, CD79A
34	vitamin d32	7.2	CD79A, IVL, ITGB3, IL10, IL1A, IL1RN
35	etanercept32 9 9	9.2	FCGR2A, FCGR3A, FCGR3B, IL10, IL15, IL17A
36	tacrolimus32 34 9 9	10.0	CD79A, CD40, ITGAL, IL10, IL13, IL15
37	ly29400232	7.0	SELE, VEGFA, FCGR2A, IL10, IL13, IL17A
38	il-1232	6.9	CD40LG, IL10, IL13, IL15, IL1B, IL2
39	fmlp32	6.8	SELL, SELPLG, VCAM1, RAC1, MPO, ITGAL
40	alanine32	6.4	SELE, SELL, SELPLG, SERPINF2, VCAM1, CD79A
41	simvastatin32 34 42 9 18 9	11.4	SELE, SELL, VEGFA, VCAM1, RAC1, CD40
42	lactate32	6.3	SELE, SELL, VCAM1, MPO, CD79A, CD40LG
43	gm-csf32	6.0	VEGFA, IL10, IL13, IL15, IL1A, IL1B
44	vegf32	6.0	SELE, SERPINF2, VCAM1, RAC1, MPO, CD40LG
45	il 1032	5.8	CD40, IL10, IL13, IL15, IL1A, IL1B
46	herbimycin a32 42	6.8	SELE, SELL, VCAM1, CD40LG, CD40, ITGA6
47	hydrocortisone32 9 9	7.6	CD40, IVL, MIF, FCER2, IL10, IL13
48	actinomycin d32	5.2	SELE, VEGFA, CD40LG, CD40, ITGAL, MMP13
49	retinoic acid32 42 18	7.0	SELL, VCAM1, RAC1, LAMA1, MPO, CD79A
50	dexamethasone32 42 34 9 9	7.0	SELL, SELPLG, VEGFA, VCAM1, LMOD1, CD79A

Cellular components related to bullous pemphigoid according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	hemidesmosome	GO:030056	10.5	DST, COL17A1, PLEC, ERBB2IP, ITGB4, ITGB1
2	basement membrane	GO:005604	10.3	DST, COL17A1, COL7A1, ERBB2IP, ITGB1, ITGA6
3	integrin complex	GO:008305	10.3	ITGAL, ITGB1, ITGB3, ITGB4
4	desmosome	GO:030057	10.3	DSP, DSG3, DSG1, PPL, EVPL
5	laminin-5 complex	GO:005610	10.1	LAMA3, LAMB3, LAMC2
6	cell surface	GO:009986	8.8	PLAT, PLAU, PLAUR, ELANE, TGFB1, TNF
7	integral to plasma membrane	GO:005887	8.2	CCR3, ICAM1, HLA-DQA1, HLA-DRB1, TNF, PLAUR
8	external side of plasma membrane	GO:009897	7.8	FCGR3A, IL13, IL17A, IL2RB, IL4, CCR4
9	extracellular region	GO:005576	6.1	MIF, IL8, CCL11, CCL17, CCL5, IGHG3
10	plasma membrane	GO:005886	5.8	TMIGD2, TNFSF13B, TNFRSF8, TNF, HLA-DRB1, HLA-DQB1
11	extracellular space	GO:005615	4.3	SELE, IL17A, IL1A, IL1B, IL1RN, IL2

Biological processes related to bullous pemphigoid according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	hemidesmosome assembly	GO:031581	10.8	LAMB3, LAMC2, CD151, ITGA6, ITGB4, PLEC
2	epidermis development	GO:008544	10.7	DSP, KRT14, KRT5, COL17A1, COL7A1, EVPL
3	eosinophil chemotaxis	GO:048245	10.7	CCL5, CCL13, CCR3, CCL11
4	integrin-mediated signaling pathway	GO:007229	10.6	DST, ERBB2IP, ITGB4, ITGB3, ITGB1, ITGAL
5	cell junction assembly	GO:034329	10.5	KRT14, KRT5, COL17A1, PLEC, INADL, ITGB4
6	chemotaxis	GO:006935	10.3	CCL13, CCL5, PLAU, PLAUR, CXCL9, CXCR3
7	leukocyte migration	GO:050900	10.3	ELANE, ICAM1, ITGB3, ITGB1, ITGAL, ITGA6
8	leukocyte tethering or rolling	GO:050901	10.3	TNF, VCAM1, SELPLG, SELE
9	cellular calcium ion homeostasis	GO:006874	10.2	TGFB1, ELANE, CCL5, CCL13, CCL1, CCL11
10	fibrinolysis	GO:042730	10.1	SERPINF2, PLAT, PLAU, PLAUR
11	leukocyte cell-cell adhesion	GO:007159	10.1	ICAM1, CCL5, ITGB1, ITGAL, CD40LG, VCAM1
12	chronic inflammatory response to antigenic stimulus	GO:002439	10.0	IL1RN, IL1B
13	cellular response to mechanical stimulus	GO:071260	10.0	TNFRSF8, IL1B, IL13, IRF1, ITGB1, CD40
14	cellular response to interleukin-1	GO:071347	10.0	ICAM1, CCL5, IL8, IL17A, IRF1
15	B cell proliferation	GO:042100	10.0	IL10, CD40, CD40LG, CD79A
16	regulation of immune response	GO:050776	9.9	ICAM1, IL4, FCGR3A, ITGB1, ITGAL, CD40
17	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.9	OSM, IL6, IL5, IL3, MIF, ITGB3
18	positive regulation of B cell proliferation	GO:030890	9.9	NFATC2, IL7, IL5, IL4, IL2, IL13
19	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	SERPINF2, IL13, IL6, CCL5, TNF, ELANE
20	positive regulation of isotype switching to IgG isotypes	GO:048304	9.7	IFNG, IL4, IL2, CD40
21	B cell differentiation	GO:030183	9.7	IL4, IL10, ITGB1, CD40LG, CD79A, VCAM1
22	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.7	OSM, TGFB1, TNF, IL6, MIF, VEGFA
23	response to activity	GO:014823	9.7	NR3C1, TNF, CCL5, IL10, ITGB1
24	cellular response to organic cyclic compound	GO:071407	9.6	TGFB1, TNF, CCL5, IL1B, ITGA6
25	aging	GO:007568	9.6	TGFB1, NR3C1, CCL5, IL1B, IL15, ATP6AP1
26	blood coagulation	GO:007596	9.5	IRF1, IRF2, F8, PLAT, PLAU, PLAUR
27	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.5	TNF, IFNG, IL1B
28	positive regulation of MHC class II biosynthetic process	GO:045348	9.5	IFNG, IL4, IL10, CD40LG
29	cellular component movement	GO:006928	9.4	CXCR3, PLAUR, IFNG, IL8, IL13, ITGAL
30	positive regulation of osteoclast differentiation	GO:045672	9.4	TNF, IFNG, CCL5, IL17A
31	positive regulation of chemokine biosynthetic process	GO:045080	9.4	TNF, IFNG, IL4, IL1B
32	wound healing	GO:042060	9.3	DSP, ERBB2, MACF1, IL1B, IL1A, ITGB3
33	positive regulation of MAP kinase activity	GO:043406	9.3	TGFB1, ELANE, TNF, ERBB2, CD40, VEGFA
34	platelet activation	GO:030168	9.2	TGFB1, F8, IL6, ITGB3, CD40, CD40LG
35	negative regulation of apoptotic process	GO:043066	9.1	KRT18, PLAUR, TNF, IL7, IL6, IL4
36	cell-cell signaling	GO:007267	9.0	CCL8, CCL26, CCL17, CCL13, CCL5, CXCL9
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	TGFB1, TNFRSF8, TNF, ICAM1, IL6, IL1B
38	cell adhesion	GO:007155	9.0	LPP, VCAM1, RAC1, LAMA1, LAMA3, LAMB3
39	interferon-gamma-mediated signaling pathway	GO:060333	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, ICAM1, IFNG, IRF2
40	positive regulation of T cell proliferation	GO:042102	8.9	IFNG, CCL5, IL6, IL4, IL1B, IL15
41	positive regulation of protein phosphorylation	GO:001934	8.8	TGFB1, TNF, ERBB2, IL1B, ITGB3, CD40
42	negative regulation of growth of symbiont in host	GO:044130	8.7	ELANE, TNF, IFNG, IL10
43	response to glucocorticoid stimulus	GO:051384	8.7	PLAT, TNF, CCL5, IL6, IL1RN, IL1B
44	positive regulation of cell proliferation	GO:008284	8.7	TNFSF13B, TGFB1, OSM, CSF3, IL7, IL6
45	signal transduction	GO:007165	8.5	TNFRSF8, TNFSF13B, NR3C1, PLAU, PLAUR, CXCL9
46	response to drug	GO:042493	8.1	ICAM1, TNF, NFATC2, TGFB1, IFNG, CCL5
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	IL6, EN1, IFNG, TNF, NFATC1, NFATC2
48	immune response	GO:006955	7.6	FCGR3A, IL5, IL8, CCL8, CCL26, CCR4
49	cytokine-mediated signaling pathway	GO:019221	7.6	IFNG, ICAM1, HLA-DQA1, HLA-DQB1, HLA-DRB1, CSF3
50	inflammatory response	GO:006954	7.5	CCL26, CCR4, CCL11, CCL17, CCR3, CCL13

Molecular functions related to bullous pemphigoid according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	glycosphingolipid binding	GO:043208	10.0	SELL, LAMA1, IL2
2	chemokine activity	GO:008009	10.0	CXCL9, CCL5, CCL13, CCL1, CCL17, CCL11
3	integrin binding	GO:005178	10.0	DST, ERBB2IP, ICAM1, FCER2, ITGB1, ITGA6
4	protease binding	GO:002020	9.7	ELANE, TNF, ITGB1, SERPINF2, SELL
5	heparin binding	GO:008201	9.6	ELANE, CCL5, CCL8, MPO, LAMC2, VEGFA
6	growth factor activity	GO:008083	7.7	IL6, IL7, TGFB1, OSM, CSF3, IL5
7	cytokine activity	GO:005125	6.5	VEGFA, IL5, IL6, IL7, IFNG, TNF
8	protein binding	GO:005515	4.9	PPL, NR3C1, PLAT, PLEC, PLAU, TNFSF13B