MCID: BLL006
MIFTS: 59

Bullous Pemphigoid malady

Categories: Rare diseases, Skin diseases, Immune diseases

Aliases & Classifications for Bullous Pemphigoid

Aliases & Descriptions for Bullous Pemphigoid:

Name: Bullous Pemphigoid 12 50 56 14 69
Senile Dermatitis Herpetiformis 50 69
Benign Pemphigus 50 69
Pemphigoid, Bullous 42
Pemphigoid Bullous 52
Old Age Pemphigus 50
Parapemphigus 50
Pemphigoid 50

Characteristics:

Orphanet epidemiological data:

56
bullous pemphigoid
Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8506
ICD10 33 L12 L12.0 L12.9
ICD9CM 35 694.5
MeSH 42 D010391
Orphanet 56 ORPHA703
MESH via Orphanet 43 D010391
UMLS via Orphanet 70 C0030805
ICD10 via Orphanet 34 L12.0
UMLS 69 C0030805

Summaries for Bullous Pemphigoid

NIH Rare Diseases : 50 bullous pemphigoid is a skin disorder characterized by large blisters. the blisters are usually located on the arms, legs, or middle of the body. in some people, the mouth or genitals are also affected. the blisters may break open and form ulcers or open sores. bullous pemphigoid usually occurs in older persons and is rare in young people. symptoms may come and go. in most patients, the condition goes away after several years. bullous pemphigoid is an autoimmune disorder which occurs when the body's immune system attacks and destroys healthy body tissue by mistake. treatment may include corticosteroids taken by mouth or applied to the skin. medicines that suppress the immune system may also be prescribed. for some, antibiotics in the tetracycline family are useful. last updated: 8/10/2016

MalaCards based summary : Bullous Pemphigoid, also known as senile dermatitis herpetiformis, is related to epidermolysis bullosa and actinic keratosis, and has symptoms including macule, diabetes mellitus and abnormal blistering of the skin. An important gene associated with Bullous Pemphigoid is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Focal Adhesion. The drugs Omalizumab and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are digestive/alimentary and craniofacial

Disease Ontology : 12 An autoimmune disease of skin and connective tissue characterized by large blisters.

Wikipedia : 71 Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters,... more...

Related Diseases for Bullous Pemphigoid

Diseases related to Bullous Pemphigoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
id Related Disease Score Top Affiliating Genes
1 epidermolysis bullosa 30.7 CCL11 CD79A DSG1 IL5 RNASE3
2 actinic keratosis 29.7 CD79A IL5 RNASE3
3 herpes zoster 29.1 CD79A COL17A1 DSG1 DSG3 DST EVPL
4 lichen planus pemphigoides 11.3
5 autoimmune disease, multisystem, infantile-onset, 2 11.0
6 pemphigus 10.5
7 epidermolysis bullosa acquisita 10.4
8 psoriasis 10.4
9 cicatricial pemphigoid 10.3
10 linear hamartoma syndrome 10.3 COL17A1 DST ITGB4
11 dermatitis 10.3
12 x-linked intellectual disability-precocious puberty-obesity syndrome 10.3 DSG3 DSP
13 dermatitis herpetiformis 10.3
14 latent syphilis 10.3 CCL11 IL5 RNASE3
15 necrotizing gastritis 10.3 CCL11 IL5 RNASE3
16 pemphigus vulgaris 10.3
17 restrictive cardiomyopathy 10.3 IL5 RNASE3
18 cerebral primitive neuroectodermal tumor 10.3 CCL11 IL5 RNASE3
19 trachea leiomyoma 10.3 CCL11 IL5 RNASE3
20 visceral steatosis 10.3 CCL11 IL5 RNASE3
21 luminal breast carcinoma 10.3 HLA-DQB1 IL5 RNASE3
22 ethmoid sinusitis 10.3 CCL11 IL5 RNASE3
23 childhood malignant mesenchymoma 10.3 CCL11 IL5 RNASE3
24 cardiomyopathy, dilated, 1bb 10.3 DSG1 DSP
25 inflamed seborrheic keratosis 10.3 CCL11 IL5 RNASE3
26 lin-gettig syndrome 10.3 COL17A1 HLA-DQB1 HLA-DRB1
27 hydrophthalmos 10.3 CCL11 IL5 RNASE3
28 patellar tendinitis 10.3 CCL11 IL5 RNASE3
29 epidermolysis bullosa simplex with nail dystrophy 10.3 ITGB4 PLEC
30 apple allergy 10.3 HLA-DQB1 HLA-DRB1
31 herpes gestationis 10.2
32 thyroid hyalinizing trabecular adenoma 10.2 CCL11 IL5 RNASE3
33 colon adenocarcinoma 10.2 CCL11 IL5 RNASE3
34 heart septal defect 10.2 CD79A RNASE3
35 hemoglobin d disease 10.2 HLA-DQB1 HLA-DRB1
36 acute dacryoadenitis 10.2 CCL11 IL5 RNASE3
37 pulmonary tuberculosis 10.2 CCL11 IL5 RNASE3
38 myalgia-eosinophilia syndrome associated with tryptophan 10.2 DSG1 DSG3 DST
39 x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome 10.2 DSG1 PPL
40 spontaneous ocular nystagmus 10.2 CCL11 IL5 RNASE3
41 pemphigus foliaceus 10.2
42 spastic diplegia 10.2 CCL11 CD79A IL5
43 brown shrimp allergy 10.2 CD79A IL5 RNASE3
44 frmd7-related infantile nystagmus 10.2 ITGA6 ITGB4 PLEC
45 birth defects 10.2 CCL11 IL5 RNASE3
46 metal allergy 10.2 CD79A IL5 RNASE3
47 small intestine lymphoma 10.2 CD79A IL5 RNASE3
48 orbit alveolar rhabdomyosarcoma 10.2 CD79A IL5 RNASE3
49 bare lymphocyte syndrome, type i 10.2 CCL11 IL5 RNASE3
50 barbiturate abuse 10.2 CCL11 CD79A HLA-DQB1

Comorbidity relations with Bullous Pemphigoid via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Pemphigus Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Bullous Pemphigoid:



Diseases related to Bullous Pemphigoid

Symptoms & Phenotypes for Bullous Pemphigoid

Human phenotypes related to Bullous Pemphigoid:

56 32 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 macule 56 32 Very frequent (99-80%) HP:0012733
2 diabetes mellitus 56 32 Very frequent (99-80%) HP:0000819
3 abnormal blistering of the skin 56 32 Very frequent (99-80%) HP:0008066
4 weight loss 56 32 Very frequent (99-80%) HP:0001824
5 autoimmunity 56 32 Very frequent (99-80%) HP:0002960
6 recurrent infections 56 32 Very frequent (99-80%) HP:0002719
7 erythema 56 32 Very frequent (99-80%) HP:0010783
8 eczema 56 32 Very frequent (99-80%) HP:0000964
9 urticaria 56 32 Very frequent (99-80%) HP:0001025
10 psoriasis 56 32 Frequent (79-30%) HP:0003765

MGI Mouse Phenotypes related to Bullous Pemphigoid:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 IL5 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
2 craniofacial MP:0005382 9.87 DSG3 DSP ITGA6 ITGB4 LAMA3 LAMB3
3 immune system MP:0005387 9.85 ITGB4 LAMA3 LAMC2 PLEC CCL11 CD79A
4 integument MP:0010771 9.61 DSG3 DSP EVPL ITGA6 ITGB4 LAMA3
5 respiratory system MP:0005388 9.28 CCL11 DSG3 HLA-DQB1 IL5 ITGA6 ITGB4

Drugs & Therapeutics for Bullous Pemphigoid

Drugs for Bullous Pemphigoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 4 242138-07-4
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Clobetasol Phase 4,Phase 3 25122-46-7 32798 5311051
4 glucocorticoids Phase 4,Phase 3
5 Hormone Antagonists Phase 4,Phase 3
6 Hormones Phase 4,Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
8 Anti-Inflammatory Agents Phase 4,Phase 3
9 Anti-Allergic Agents Phase 4
10 Anti-Asthmatic Agents Phase 4
11 Immunoglobulin E Phase 4
12 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
13 Respiratory System Agents Phase 4
14 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Hormonal Phase 4
16
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
17
Mycophenolic acid Approved Phase 3,Phase 2 24280-93-1 446541
18
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2 128794-94-5 5281078
19
rituximab Approved Phase 3,Phase 1,Phase 2 174722-31-7 10201696
20
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
22 Folic Acid Antagonists Phase 3
23 Nucleic Acid Synthesis Inhibitors Phase 3
24 Dermatologic Agents Phase 3,Phase 1,Phase 2
25 Vitamin B Complex Phase 3,Phase 1,Phase 2
26 Immunosuppressive Agents Phase 3,Phase 2
27 Antimetabolites Phase 3,Phase 2,Phase 1
28 Antimetabolites, Antineoplastic Phase 3,Phase 2
29 Antirheumatic Agents Phase 3,Phase 2,Phase 1
30 Anti-Bacterial Agents Phase 3,Phase 2
31 gamma-Globulins Phase 3,Phase 2,Phase 1
32 Immunoglobulins, Intravenous Phase 3,Phase 2,Phase 1
33 Antibiotics, Antitubercular Phase 3,Phase 2
34 Rho(D) Immune Globulin Phase 3,Phase 2,Phase 1
35 Folate Nutraceutical Phase 3,Phase 1,Phase 2
36 Vitamin B9 Nutraceutical Phase 3,Phase 1,Phase 2
37
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
38
Azathioprine Approved Phase 2 446-86-6 2265
39
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
40
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
41
Infliximab Approved Phase 1, Phase 2 170277-31-3
42
Riboflavin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 83-88-5 493570
43 Gastrointestinal Agents Phase 1, Phase 2
44 Prednisolone acetate Phase 2
45 Trace Elements Phase 1, Phase 2
46 Vitamins Phase 1, Phase 2
47 Prednisolone hemisuccinate Phase 2
48 Prednisolone phosphate Phase 2
49 Methylprednisolone acetate Phase 2
50 Methylprednisolone Hemisuccinate Phase 2

Interventional clinical trials:

(show all 41)
id Name Status NCT ID Phase
1 Efficacy and Safety of Omalizumab in Bullous Pemphigoid Completed NCT00472030 Phase 4
2 Comparison of Two Therapeutic Strategies of Dermoval in Treatment of Bullous Pemphigus Completed NCT00213421 Phase 4
3 Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid Recruiting NCT02360202 Phase 4
4 Topical Steroids Alone or Associated With Methotrexate in Bullous Pemphigoid Unknown status NCT02313870 Phase 3
5 Efficiency and Tolerance of Rituximab (mabthéra) in Bullous Pemphigoid Completed NCT00525616 Phase 3
6 Phase III Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids Completed NCT01408550 Phase 3
7 Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid. Not yet recruiting NCT02993133 Phase 3
8 Leflunomide Associated With Topical Corticosteroids for Bullous Pemphigoid Unknown status NCT00802243 Phase 2
9 Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids. Completed NCT00809822 Phase 2
10 Rituximab in the Treatment of Patients With Bullous Pemphigoid Completed NCT00286325 Phase 1, Phase 2
11 Azathioprine or Mycophenolate Mofetil for Bullous Pemphigoid Completed NCT00431119 Phase 2
12 Anti-IL-5 Therapy in Bullous Pemphigoid (BP) Completed NCT01705795 Phase 2
13 Clinical Trial Evaluating Rituximab in Ocular Cicatricial Pemphigoid Completed NCT00584935 Phase 1, Phase 2
14 Evaluation of Safety, Efficacy and Pharmacodynamic Effect of Bertilimumab in Patients With Bullous Pemphigoid Recruiting NCT02226146 Phase 2
15 Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Recruiting NCT02318485 Phase 2
16 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Recruiting NCT01582880 Phase 1, Phase 2
17 Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation Available NCT02149732 Phase 1, Phase 2
18 Ixekizumab in the Treatment of Bullous Pemphigoid Not yet recruiting NCT03099538 Phase 2
19 Safety, Efficacy and PK/PD of QGE031 vs. Placebo in Patients With Active Bullous Pemphigoid Despite Oral Steroid Treatment Terminated NCT01688882 Phase 2
20 Pilot Efficacy and Safety Study of Oral DF2156A in Patients With Active Bullous Pemphigoid Terminated NCT01571895 Phase 2
21 Topical Infliximab in Autoimmune Eyes With Keratoprosthesis Withdrawn NCT02126020 Phase 1, Phase 2
22 The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem Cells Unknown status NCT02202642 Phase 1
23 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Malignancies Completed NCT00691210 Phase 1
24 Safety, Tolerability and Activity of TNT009 in Healthy Volunteers and Patients With Complement Mediated Disorders Recruiting NCT02502903 Phase 1
25 Topical Infliximab for Sterile Corneal Melt Not yet recruiting NCT02987686 Phase 1
26 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1
27 Explore the Mechanisms of Pruritus in Bullous Pemphigoid Patients During Remission Unknown status NCT01265082
28 Wound Dressings for Pemphigus and Pemphigoid Unknown status NCT02365675
29 Interest of Dosage of Anti-PB230, Anti-PB180 and Cytokines for Monitoring of Patients Suffering From Bullous Pemphigoid Completed NCT02883894
30 Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Completed NCT00116090
31 A Study of the Association of Sleep Dysfunction and Burning Mouth Syndrome Completed NCT00862576
32 Observational Study Assessing Outcomes, Treatment Patterns and Related Costs in Patients in Bullous Pemphigoid Recruiting NCT02837965
33 Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid Recruiting NCT02874079
34 Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid Recruiting NCT01559155
35 Pruritus and Pemphigoid in Nursing Home Patients Recruiting NCT02823067
36 Autoimmune Blistering Diseases Study Recruiting NCT02753777
37 Identification of Vulnerability Factors in the Course of Pemphigus Patients Recruiting NCT02237313
38 Register of Autoimmune Bullous Dermatoses Recruiting NCT02899923
39 Prevalence of Cutaneous Autoimmune Phenomena in HIV Infected Patients Recruiting NCT03129308
40 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases Enrolling by invitation NCT00357071
41 Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids Not yet recruiting NCT02872584

Search NIH Clinical Center for Bullous Pemphigoid

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pemphigoid, bullous

Genetic Tests for Bullous Pemphigoid

Anatomical Context for Bullous Pemphigoid

MalaCards organs/tissues related to Bullous Pemphigoid:

39
Skin, T Cells, Testes, Neutrophil, B Cells, Breast, Thyroid

Publications for Bullous Pemphigoid

Articles related to Bullous Pemphigoid:

(show top 50) (show all 952)
id Title Authors Year
1
Immunoglobulin E Autoantibodies in Bullous Pemphigoid Detected by Immunoglobulin E Enzyme-Linked Immunosorbent Assays. ( 27829077 )
2017
2
Bullous pemphigoid induced by photodynamic therapy: when light is guilty. ( 28369769 )
2017
3
Survey of bullous pemphigoid in an Italian University hospital: clinical-epidemiological characteristics and follow-up. ( 28079339 )
2017
4
A randomized double-blind trial of intravenous immunoglobulin for bullous pemphigoid. ( 27876358 )
2017
5
Serum levels and tissue expression of interleukin-31 in dermatitis herpetiformis and bullous pemphigoid. ( 28465041 )
2017
6
Complement-independent blistering mechanisms in bullous pemphigoid. ( 28418613 )
2017
7
Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study. ( 28467996 )
2017
8
Bullous hemorrhagic dermatosis due to enoxaparin use in a bullous pemphigoid patient. ( 28487841 )
2017
9
Extensive milia formation in a young woman with bullous pemphigoid. ( 28440230 )
2017
10
Bullous Pemphigoid associated with Dipeptidyl Peptidase-4 Inhibitors: A Report of Five Cases. ( 28520234 )
2017
11
Membranous glomerulonephropathy in a patient with bullous pemphigoid. ( 28509127 )
2017
12
Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature. ( 28458935 )
2017
13
Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid. ( 28500685 )
2017
14
Bullous pemphigoid and systemic sclerosis: an incidental association? ( 28468735 )
2017
15
Multimorbidity in Bullous Pemphigoid: a case-control analysis of BP patients with age and gender matched controls. ( 28485892 )
2017
16
A randomised controlled trial to compare the safety, effectiveness and cost-effectiveness of doxycycline (200a88mg/day) with that of oral prednisolone (0.5a88mg/kg/day) for initial treatment of bullous pemphigoid: the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial. ( 28406394 )
2017
17
Rituximab Treatment of Nivolumab-Induced Bullous Pemphigoid. ( 28355425 )
2017
18
An open, multicenter, randomized clinical study in patients with bullous pemphigoid comparing methylprednisolone and azathioprine with methylprednisolone and dapsone. ( 28494097 )
2017
19
Langerhans cells are predominant high affinity immunoglobulin E receptor bearing cells in the epidermis of bullous pemphigoid skin. ( 27839901 )
2017
20
Correlation of Serum Levels of IgE Autoantibodies Against BP180 With Bullous Pemphigoid Disease Activity. ( 27829102 )
2017
21
Positive clinical outcome in a patient with recalcitrant bullous pemphigoid treated with rituximab and intravenous immunoglobulin. ( 28508388 )
2017
22
Successful Treatment of a Bullous Pemphigoid Patient with Rituximab Who Was Refractory to Corticosteroid and Omalizumab Treatments. ( 28413387 )
2017
23
Bullous Pemphigoid Successfully Treated With a Combination Therapy of Plasmapheresis Followed by Intravenous High Dose Immunoglobulin. ( 28378368 )
2017
24
Bullous pemphigoid with IgG autoantibodies to the I+3 subunit of laminin 332 associated with psoriasis vulgaris. ( 28468743 )
2017
25
Photodynamic Therapy Effective for the Treatment of Actinic Keratosis and Basal Cell Carcinoma in Bullous Pemphigoid Patients. ( 28373119 )
2017
26
Successful treatment of bullous pemphigoid with omalizumab as corticosteroid-sparing agent: report of two cases and review of literature. ( 27357866 )
2016
27
An autoimmune bullous dermatosis with clinical, histopathological, and immunological features of bullous pemphigoid and epidermolysis bullosa acquisita in an adult. ( 26989994 )
2016
28
Salivary IgA and IgG antibodies to bullous pemphigoid 180 noncollagenous domain 16a as diagnostic biomarkers in mucous membrane pemphigoid. ( 26676445 )
2016
29
High-Frequency Color Doppler Sonography of Bullous Pemphigoid: Correlation With Histologic Findings. ( 27371374 )
2016
30
Etanercept-induced generalization of chronic, localized, anogenital bullous pemphigoid in a psoriatic patient. ( 27051819 )
2016
31
Correlation of autoantibodies against BP180/BP230 in response to topical corticosteroids in patients with bullous pemphigoid. ( 27550573 )
2016
32
A possible interaction between periostin and CD163+ skin-resident macrophages in pemphigus vulgaris and bullous pemphigoid. ( 27501402 )
2016
33
Bullous pemphigoid and primary biliary cirrhosis, an infrequent association: A case report. ( 26949192 )
2016
34
Diagnostic value of immunohistochemistry on formalin-fixed paraffin-embedded skin biopsy specimens for bullous pemphigoid. ( 27105821 )
2016
35
Cutaneous Exophiala oligosperma Infection in a Patient with Bullous Pemphigoid with a Review of the Literature. ( 28025758 )
2016
36
Late presentation of generalised bullous pemphigoid-like reaction in a patient treated with pembrolizumab for metastatic melanoma. ( 27170423 )
2016
37
Quality of life, depression, anxiety and loneliness in patients with bullous pemphigoid. A case control study. ( 27828632 )
2016
38
Herpes simplex encephalitis without cerebrospinal fluid pleocytosis in a patient with bullous pemphigoid: a case report. ( 27247185 )
2016
39
Pyodermatitis vegetans with antibodies to bullous pemphigoid antigen 180. ( 27914095 )
2016
40
Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review. ( 27469343 )
2016
41
Case of bullous pemphigoid in a 28-year-old woman affected by tuberous sclerosis complex. ( 27400884 )
2016
42
Dipeptidyl peptidase-IV inhibitors induced bullous pemphigoid: a case report and analysis of cases reported in the European pharmacovigilance database. ( 27191539 )
2016
43
Combination therapy of prednisolone and i.v. immunoglobulin treatment decreases circulating interleukin-5 and eosinophils in a patient with bullous pemphigoid. ( 27154738 )
2016
44
Disease stabilization with pembrolizumab for metastatic acral melanoma in the setting of autoimmune bullous pemphigoid. ( 27096097 )
2016
45
Bullous pemphigoid-like skin blistering disease in a rhesus macaque (Macaca mulatta). ( 27373989 )
2016
46
A Potential Link between Amyotrophic Lateral Sclerosis and Bullous Pemphigoid: Six New Cases and a Systematic Review of the Literature. ( 27477403 )
2016
47
Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid. ( 26981743 )
2016
48
Disseminated acantholytic acanthomas in a patient with bullous pemphigoid. ( 28007675 )
2016
49
Bullous pemphigoid triggered by radiotherapy for breast cancer. ( 27818063 )
2016
50
Bullous pemphigoid developed in a patient with prurigo nodularis. ( 27511319 )
2016

Variations for Bullous Pemphigoid

Expression for Bullous Pemphigoid

Search GEO for disease gene expression data for Bullous Pemphigoid.

Pathways for Bullous Pemphigoid

Pathways related to Bullous Pemphigoid according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CD79A COL17A1 ITGA6 ITGB4 LAMA3 LAMB3
2
Show member pathways
12.78 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
3
Show member pathways
12.74 CCL11 HLA-DQB1 HLA-DRB1 IL5 RNASE3
4
Show member pathways
12.69 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
5
Show member pathways
12.58 COL17A1 DST ITGA6 ITGB4 LAMA3 LAMB3
6 12.5 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
7
Show member pathways
12.34 DSG1 DSG3 DSP EVPL IVL PPL
8
Show member pathways
12.22 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
9
Show member pathways
12.21 COL17A1 DST ITGA6 ITGB4 LAMA3 LAMB3
10
Show member pathways
12.07 HLA-DQB1 HLA-DRB1 ITGA6 LAMA3 LAMB3 LAMC2
11
Show member pathways
12.01 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
12
Show member pathways
11.91 DSG1 DSG3 DSP PLEC
13 11.85 DSP ITGA6 ITGB4 PLEC
14
Show member pathways
11.85 COL17A1 DST ITGA6 ITGB4 LAMA3 LAMB3
15
Show member pathways
11.8 DSP DST EVPL PLEC PPL
16 11.78 HLA-DQB1 HLA-DRB1 IL5 ITGA6
17 11.77 LAMA3 LAMB3 LAMC2
18 11.68 ITGA6 LAMA3 LAMB3 LAMC2
19 11.57 CCL11 DSP IL5
20 11.55 LAMA3 LAMB3 LAMC2
21 11.5 DSG1 HLA-DQB1 HLA-DRB1
22
Show member pathways
11.38 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
23 11.27 ITGB4 IVL LAMA3
24 11.2 COL17A1 ITGA6 ITGB4

GO Terms for Bullous Pemphigoid

Cellular components related to Bullous Pemphigoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.97 COL17A1 DSG1 DSG3 DSP DST EVPL
2 basement membrane GO:0005604 9.73 COL17A1 DST ITGA6 LAMA3 LAMB3 LAMC2
3 desmosome GO:0030057 9.55 DSG1 DSG3 DSP EVPL PPL
4 MHC class II protein complex GO:0042613 9.43 HLA-DQB1 HLA-DRB1
5 cornified envelope GO:0001533 9.43 DSG1 DSG3 DSP EVPL IVL PPL
6 laminin-5 complex GO:0005610 9.4 LAMA3 LAMB3
7 hemidesmosome GO:0030056 9.02 COL17A1 DST ITGA6 ITGB4 PLEC
8 extracellular exosome GO:0070062 10.15 DSG1 DSG3 DSP DST EVPL HLA-DRB1

Biological processes related to Bullous Pemphigoid according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.91 CCL11 DSG1 DSG3 DST ITGA6 ITGB4
2 keratinization GO:0031424 9.8 DSG1 DSG3 DSP EVPL IVL PPL
3 extracellular matrix organization GO:0030198 9.77 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
4 single organismal cell-cell adhesion GO:0016337 9.75 DSG1 DSP ITGA6
5 cell-matrix adhesion GO:0007160 9.74 COL17A1 ITGA6 ITGB4
6 integrin-mediated signaling pathway GO:0007229 9.72 DST ITGA6 ITGB4
7 extracellular matrix disassembly GO:0022617 9.71 LAMA3 LAMB3 LAMC2
8 keratinocyte differentiation GO:0030216 9.7 DSP EVPL IVL
9 peptide cross-linking GO:0018149 9.65 DSP EVPL IVL
10 cornification GO:0070268 9.63 DSG1 DSG3 DSP EVPL IVL PPL
11 skin development GO:0043588 9.61 DSP ITGA6 ITGB4
12 intermediate filament cytoskeleton organization GO:0045104 9.58 DSP DST
13 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.56 HLA-DQB1 HLA-DRB1
14 amelogenesis GO:0097186 9.51 ITGA6 ITGB4
15 nail development GO:0035878 9.49 ITGA6 ITGB4
16 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.46 HLA-DQB1 HLA-DRB1
17 epidermis development GO:0008544 9.43 COL17A1 DSP EVPL LAMA3 LAMB3 LAMC2
18 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DQB1 HLA-DRB1
19 hemidesmosome assembly GO:0031581 9.17 COL17A1 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2

Molecular functions related to Bullous Pemphigoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.67 EVPL ITGA6 PLEC PPL
2 protein binding, bridging GO:0030674 9.43 DSP EVPL IVL
3 insulin-like growth factor I binding GO:0031994 9.32 ITGA6 ITGB4
4 MHC class II receptor activity GO:0032395 9.16 HLA-DQB1 HLA-DRB1
5 structural molecule activity GO:0005198 9.02 DSP EVPL IVL LAMA3 LAMB3
6 neuregulin binding GO:0038132 8.96 ITGA6 ITGB4

Sources for Bullous Pemphigoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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