MCID: BRK010
MIFTS: 67

Burkitt Lymphoma malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Burkitt Lymphoma

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MedlinePlus:34 Lymphoma is a cancer of a part of the immune system called the lymph system. there are many types of lymphoma. one type is hodgkin disease. the rest are called non-hodgkin lymphomas. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors don't know why a person gets non-hodgkin lymphoma. you are at increased risk if you have a weakened immune system or have certain types of infections. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. targeted therapy uses substances that attack cancer cells without harming normal cells. biologic therapy boosts your body's own ability to fight cancer. if you don't have symptoms, you may not need treatment right away. this is called watchful waiting. nih: national cancer institute

MalaCards based summary: Burkitt Lymphoma, also known as lymphoma, is related to hodgkin lymphoma and follicular lymphoma, and has symptoms including lymphoma An important gene associated with Burkitt Lymphoma is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways are FoxO family signaling and Lymphocyte Signaling. The drug cyclophosphamide and the compounds suberoylanilide hydroxamic acid and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are no phenotypic analysis and homeostasis/metabolism.

Disease Ontology:10 A mature b-cell neoplasm of b-cells found in the germinal center.

NIH Rare Diseases:43 Burkitt lymphoma (bl) is a rare, aggressive form of b-cell non-hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. it is more common in males than females. three forms exist: one endemic to africa that is linked to the epstein barr virus (ebv); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with hiv infection. bl can also develop in the ear, nose, throat and more rarely in other locations. signs and symptoms may differ depending on the form of bl and the organs or body systems affected. the exact cause of the condition is not known. treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. last updated: 6/26/2012

OMIM:47 Burkitt lymphoma is a rare, aggressive B-cell lymphoma that accounts for 30 to 50% of lymphomas in children but only 1... (113970) more...

Aliases & Classifications for Burkitt Lymphoma

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Sources:
47OMIM, 10Disease Ontology, 11diseasecard, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 32LifeMap Discovery®, 12DISEASES, 34MedlinePlus, 24GTR, 40NCIt, 35MeSH, 62UMLS, 57SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 27ICD10
See all sources

Burkitt Lymphoma, Aliases & Descriptions:

Name: Burkitt Lymphoma 47 10 11 43 45 49 32
Lymphoma 10 12 45 34
Burkitt's Lymphoma 32 10 43
Small Non-Cleaved Cell Lymphoma 43 49
Burkitts Lymphoma 12 24
Small Non-Cleaved Cell Lymphoma, Burkitt's Type 10
 
Malignant Lymphoma, Burkitt's Type 10
Burkitt Lymphoma/leukaemia 10
Lymphoid Neoplasm 45
Lymphoid Cancer 10
Burkitt's Tumor 10
Bl 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
burkitt lymphoma:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-5/10000 (Africa),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age


External Ids:

OMIM47 113970
Disease Ontology10 DOID:8584, DOID:0060058
ICD9CM29 200.2
Orphanet49 543
ICD10 via Orphanet28 C83.7
UMLS via Orphanet63 C0006413, C0079770
MESH via Orphanet36 D002051, D008228
ICD1027 C83.7

Related Diseases for Burkitt Lymphoma

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Diseases related to Burkitt Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1202)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin lymphoma31.8AICDA, IGHM, SH2D1A, MPP1, TCL1A, IL13RA2
2follicular lymphoma31.7AICDA, IGHM, MYC, TCL1A, CXCR5, BCL6
3malt lymphoma31.7IGHM, CXCR5, BCL6
4central nervous system lymphoma31.7BCL6
5peripheral t-cell lymphoma31.6TCL1A, BCL6
6primary effusion lymphoma31.5BCL6, TCL1A, MYC
7intraocular lymphoma31.3CXCR5
8b-cell lymphomas31.0AICDA, IGHM, MYC, TCL1A, CXCR5, BCL6
9leukemia30.8AICDA, SH2D1A, MYC, TCL1A, CXCR5, BCL6
10chronic lymphocytic leukemia30.5AICDA, IGHM, TCL1A, BCL6
11plasmacytoma30.5AICDA, MYC, CXCR5, BCL6
12lymphoma, non-hodgkin30.4AICDA, SH2D1A, MYC, TCL1A, CXCR5, BCL6
13prolymphocytic leukemia30.4TCL1A, MYC
14central nervous system lymphoma, primary30.3BCL6, CXCR5, IGHM
15common variable immunodeficiency30.1SH2D1A, AICDA
16hiv-130.1AICDA, IGHM, TCL1A, BCL6
17precursor b-cell acute lymphoblastic leukemia30.1CXCR5, MYC
18myeloma30.1IGHM, MYC, TCL1A, CXCR5, BCL6, BCL2L11
19agammaglobulinemia30.1SH2D1A, IGHM
20ipex syndrome29.4AICDA, IGHM, SH2D1A, MPP1, CXCR5, BCL6
21mantle cell lymphoma11.2
22anaplastic large cell lymphoma11.2
23cutaneous t cell lymphoma11.1
24small non-cleaved cell lymphoma11.0
25marginal zone b-cell lymphoma11.0
26gastric lymphoma11.0
27adult t-cell leukemia11.0
28angioimmunoblastic t-cell lymphoma10.9
29thyroiditis10.9
30mediastinitis10.9
31primary malignant lymphoma10.9
32intravascular large b-cell lymphoma10.8
33thyroid lymphoma10.8
34panniculitis10.8
35sarcoma10.8
36subcutaneous panniculitis-like t-cell lymphoma10.8
37cerebritis10.8
38breast lymphoma10.8
39enteropathy-associated t-cell lymphoma10.7
40nodular lymphocyte predominant hodgkin lymphoma10.7
41gastrointestinal lymphoma10.7
42mycosis fungoides10.7
43primary mediastinal large b-cell lymphoma10.7
44cerebral lymphoma10.7
45composite lymphoma10.7
46diffuse large b-cell lymphoma10.7
47lymphomatoid papulosis10.7
48testicular lymphoma10.7
49alk-positive anaplastic large cell lymphoma10.7
50hepatosplenic t-cell lymphoma10.7

Graphical network of the top 20 diseases related to Burkitt Lymphoma:



Diseases related to burkitt lymphoma

Symptoms for Burkitt Lymphoma

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Symptoms by clinical synopsis from OMIM:

113970

Clinical features from OMIM:

113970

HPO human phenotypes related to Burkitt Lymphoma:

id Description Frequency HPO Source Accession
1 lymphoma HP:0002665

Drugs & Therapeutics for Burkitt Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Burkitt Lymphoma

Search NIH Clinical Center for Burkitt Lymphoma

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Burkitt Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Burkitt Lymphoma

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Genetic tests related to Burkitt Lymphoma:

id Genetic test Affiliating Genes
1 Burkitt Lymphoma24

Anatomical Context for Burkitt Lymphoma

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MalaCards organs/tissues related to Burkitt Lymphoma:

33
B cells, T cells, Lymph node, Testes, Bone, Bone marrow, Lung, Liver, Ovary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Burkitt Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Burkitt Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Burkitt Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6BCL2L11, BCL6, MYC, IGHM, AICDA
2MP:00053768.0GALK1, BCL2L11, BCL6, IL13RA2, MYC, SH2D1A
3MP:00053847.7BCL2L11, MPP1, IGHM, AICDA, CXCR5, BCL6
4MP:00053977.0BCL2L11, BCL6, IL13RA2, CXCR5, MYC, MPP1
5MP:00053876.9IL13RA2, BCL6, BCL2L11, MPP1, SH2D1A, IGHM

Publications for Burkitt Lymphoma

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Articles related to Burkitt Lymphoma:

(show top 50)    (show all 163)
idTitleAuthorsYear
1
Survival of AIDS-related diffuse large B-cell lymphoma, Burkitt lymphoma, and plasmablastic lymphoma in the German HIV Lymphoma Cohort. (25403997)
2014
2
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
3
Ileocolic intussusception due to Burkitt lymphoma: a case report. (23599821)
2013
4
Decitabine represses translocated MYC oncogene in Burkitt lymphoma. (23341364)
2013
5
Re-expression of microRNA-150 induces EBV-positive Burkitt lymphoma differentiation by modulating c-Myb in vitro. (23521217)
2013
6
Biologic characterization of adult MYC-translocation positive mature B-cell lymphomas other than molecular Burkitt lymphoma. (24179151)
2013
7
Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement. (23012230)
2013
8
Triple-hit B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma associated with a novel complex karyotype including t(2;3)(q21;q27), t(8;14)(q24;q32) and t(14;18)(q32;q21). (23205706)
2013
9
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and burkitt lymphoma: study of 39 cases. (23600716)
2013
10
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome. (21969235)
2012
11
E2F4 plays a key role in Burkitt lymphoma tumorigenesis. (22475873)
2012
12
Relationship of Epstein-Barr virus and interleukin 10 promoter polymorphisms with the risk and clinical outcome of childhood Burkitt lymphoma. (23029361)
2012
13
Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. (21882178)
2012
14
PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis. (22312369)
2012
15
Angioedema associated with dihydropyridine calcium-channel blockers in a child with Burkitt lymphoma. (21330681)
2011
16
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
17
Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas. (20348878)
2010
18
Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach. (19844983)
2010
19
Primary hepatic burkitt lymphoma presenting with acute liver failure. (20405241)
2010
20
Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. (20023257)
2010
21
Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma. (20428981)
2010
22
Burkitt lymphoma in the setting of common variable immunodeficiency. (19252909)
2009
23
Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma. (19302917)
2009
24
Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma. (19144381)
2009
25
pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda. (19691827)
2009
26
A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab. (18544085)
2008
27
CD40L-mediated inhibition of NF-kappaB in CA46 Burkitt lymphoma cells promotes apoptosis. (18661398)
2008
28
Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. (18792542)
2008
29
Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia. (17387701)
2008
30
Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3. (17613536)
2007
31
Successful management of bleeding with recombinant factor VIIa (NovoSeven) in a patient with Burkitt lymphoma and thrombosis of the left femoral and left common iliac veins. (16514611)
2007
32
Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors. (17485552)
2007
33
IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines. (16332968)
2006
34
Burkitt lymphoma-induced ileocolic intussusception in Wiskott-Aldrich syndrome. (16394894)
2006
35
Burkitt lymphoma in a child with Joubert syndrome. (15562502)
2005
36
Burkitt lymphoma and Williams syndrome: a model for children with a multisystem disorder and malignancy. (15701989)
2005
37
The human Burkitt lymphoma cell line Namalwa represents a homogenous cell system characterized by high levels of Toll-like receptor 9 and activation by CpG oligonucleotides. (15894327)
2005
38
Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. (12515726)
2003
39
Zinc-mediated regulation of caspases activity: dose-dependent inhibition or activation of caspase-3 in the human Burkitt lymphoma B cells (Ramos). (11313717)
2001
40
Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. (10764829)
2000
41
Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line. (10333297)
1999
42
Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL60 Burkitt lymphoma cells. (9485209)
1998
43
CD40-triggered protein tyrosine phosphorylation on Vav and on phosphatidylinositol 3-kinase correlates with survival of the Ramos-Burkitt lymphoma B cell line. (9178638)
1997
44
Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma. (8690509)
1996
45
Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines. (1459737)
1992
46
The effect of cytokines and mitogens on the induction of C epsilon germline transcripts in a human Burkitt lymphoma B cell line. (1498085)
1992
47
Disseminated strongyloidiasis with central nervous system involvement diagnosed antemortem in a patient with acquired immunodeficiency syndrome and Burkitts lymphoma. (2245399)
1990
48
Recurrent mutation of immunoglobulin and c-myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a Burkitt lymphoma. (2298494)
1990
49
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma. (2470097)
1989
50
Rearrangement of immunoglobulin kappa gene in a variant-type Burkitt lymphoma cell line, KOBK101, carrying a translocation between chromosomes 2 and 8. (3082812)
1986

Variations for Burkitt Lymphoma

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Clinvar genetic disease variations for Burkitt Lymphoma:

7
id Gene Variation Type Significance SNP ID Assembly Location
1MYCNM_002467.4(MYC): c.214C> T (p.Pro72Ser)single nucleotide variantPathogenicrs28933407GRCh37Chr 8, 128750677: 128750677
2MYCNM_002467.4(MYC): c.302A> C (p.Asn101Thr)single nucleotide variantPathogenicrs121918683GRCh37Chr 8, 128750765: 128750765
3MYCNM_002467.4(MYC): c.162G> C (p.Glu54Asp)single nucleotide variantPathogenicrs121918684GRCh37Chr 8, 128750625: 128750625
4MYCNM_002467.4(MYC): c.220C> G (p.Pro74Ala)single nucleotide variantPathogenicrs121918685GRCh37Chr 8, 128750683: 128750683

Cosmic variations for Burkitt Lymphoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144571TP53haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,Hodgkin lymphoma1

Expression for genes affiliated with Burkitt Lymphoma

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Search GEO for disease gene expression data for Burkitt Lymphoma.

Pathways for genes affiliated with Burkitt Lymphoma

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Pathways related to Burkitt Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7BCL2L11, BCL6
29.4BCL6, SH2D1A, AICDA
3
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.4BCL2L11, BCL6, MYC
49.4IGHM, BCL6, BCL2L11
59.1BCL6, IL13RA2, AICDA

Compounds for genes affiliated with Burkitt Lymphoma

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Sources:
45Novoseek, 26HMDB, 13DrugBank, 51PharmGKB
See all sources

Compounds related to Burkitt Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1suberoylanilide hydroxamic acid459.9BCL2L11, MYC
2depsipeptide459.8BCL2L11, MYC
3cytidine45 26 1311.6BCL6, MYC, AICDA
4imatinib45 51 1311.5BCL2L11, BCL6, MYC
5cycloheximide459.2AICDA, MYC, BCL6, BCL2L11
6threonine458.9SH2D1A, MYC, TCL1A, GALK1

GO Terms for genes affiliated with Burkitt Lymphoma

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Biological processes related to Burkitt Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00432809.9BCL2L11, MYC

Products for genes affiliated with Burkitt Lymphoma

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Sources for Burkitt Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet