Burkitt's Lymphoma malady

MedlinePlus: Lymphoma is a cancer of a part of the immune system called the lymphatic system. there are many types of lymphoma. one type is called hodgkin disease. the rest are called non-hodgkin lymphoma. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors can't determine why a person gets non-hodgkin lymphoma. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will perform an exam and lab tests to determine if you have lymphoma. nih: national cancer institute²³

MalaCards: Burkitt's Lymphoma, also known as burkitt lymphoma, is related to non-hodgkin lymphoma and cutaneous t cell lymphoma. An important gene associated with Burkitt's Lymphoma is CXCR5 (chemokine (C-X-C motif) receptor 5), and among its related pathways are Apoptosis and Autophagy and Lymphocyte Signaling. The drugs cyclophosphamide and doxorubicin hydrochloride and the compounds calcium and glucose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and nk cells, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.⁶

Genetics Home Reference: X-linked lymphoproliferative disease (XLP) is a disorder of the immune system and blood-forming cells that is found almost exclusively in males. More than half of individuals with this disorder experience an exaggerated immune response to the Epstein-Barr virus (EBV). EBV is a very common virus that eventually infects most humans. In some people it causes infectious mononucleosis (commonly known as "mono"). Normally, after initial infection, EBV remains in certain immune system cells (lymphocytes) called B cells. However, the virus is generally inactive (latent) because it is controlled by other lymphocytes called T cells that specifically target EBV-infected B cells.¹⁷

NIH Rare Diseases: Burkitt lymphoma (BL) is a rare, aggressive form of B-cell non-Hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. It is more common in males than females. Three forms exist: one endemic to Africa that is linked to the Epstein Barr virus (EBV); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with HIV infection. BL can also develop in the ear, nose, throat and more rarely in other locations. Signs and symptoms may differ depending on the form of BL and the organs or body systems affected. The exact cause of the condition is not known. Treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%.³⁰

OMIM: 113970

Aliases & Descriptions:

burkitt's lymphoma 6 30 burkitt lymphoma 6 7 30 33 32 43 lymphoma 6 7 8 32 23 43 burkitt's lymphoma of unspecified site (disorder) 6 small non-cleaved cell lymphoma, burkitt's type 6 burkitt's tumor nos (morphologic abnormality) 6 burkitt's tumors (morphologic abnormality) 6 malignant lymphoma, burkitt's type 6 burkitt's lymphoma nos (disorder) 6

lymphoma, small noncleaved-cell 43 burkitt's lymphoma - disorder 6 burkitt lymphoma/leukaemia 6 burkitts lymphoma 8 lymphatic cancer 43 burkitt's tumour 6 burkitt's tumor 6 lymphoid cancer 6 bl 30

Diseases related to burkitt's lymphoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1004)

id	Related Disease	Score	Top Affiliating Genes
1	non-hodgkin lymphoma	38.4	PIM1, SH2D1A, KITLG, RB1, RBL2, MYC
2	cutaneous t cell lymphoma	37.7	MYB, RARA, BIRC5, BAX, ITGA4, ITGAL
3	adult t-cell leukemia	37.5	PIM1, MYC, MYB, PAX5, BCL2, BCL2L1
4	peripheral t-cell lymphoma	37.3	PAX5, BCL6, ZAP70, MS4A1, MCL1, ALK
5	b-cell non-hodgkin lymphoma	36.6	SH2D1A, RB1, MYC, BMI1, BIRC5, PAX5
6	malt lymphoma	36.2	MYC, BIRC2, BIRC3, BCL2, BCL6, ZAP70
7	lymphoblastic lymphoma	35.9	RAG1, PAX5, BCL6, MS4A1, DNTT, E2F1
8	primary effusion lymphoma	35.7	MYC, BCL6, IL7, TCL1A
9	leukemia/lymphoma	35.5	PIK3CG, KITLG, RB1, MYC, MYCN, RAG1
10	follicular lymphoma	35.3	MYC, MYB, BMI1, BIRC2, BIRC3, PAX5
11	b-cell lymphomas	35.3	PIM1, RB1, RBL1, MYC, MYCN, BMI1
12	gastric lymphoma	34.8	BCL2, BCL6, CDKN2A, CD40LG, CD44, FCER2
13	anaplastic large cell lymphoma	34.8	RB1, MYC, BIRC2, BIRC3, BIRC5, PAX5
14	splenic marginal zone lymphoma	34.7	BIRC3, PAX5, BCL6, BCR, CDK6, CD40
15	multiple myeloma	34.3	BCL2L1, CD44, ITGA4, MCL1, CCND3, CCND1
16	central nervous system lymphoma	34.3	PIM1, RB1, MYC, BIRC5, PAX5, BCL2
17	hodgkin's lymphoma	34.2	PIK3CG, SH2D1A, BMI1, RAG1, BLZF1, BIRC2
18	chronic lymphocytic leukemia	34.2	MYB, BLZF1, BIRC2, BIRC3, BIRC5, PAX5
19	acute lymphoblastic leukemia	33.9	KITLG, RB1, MYCN, MYB, RAG1, BIRC2
20	plasmacytoma	33.8	MYC, BLZF1, PAX5, BCL2, BCL2L1, BCL6
21	marginal zone b-cell lymphoma	33.7	PIM1, RB1, BIRC3, PAX5, BCL6, CDKN2A
22	kaposi's sarcoma	33.6	CFLAR, CEBPB, CDK6, IL13RA2, IL4R, IL6R
23	intraocular lymphoma	33.6	BCL2, BCL6, IL10, IL4, CXCR4, CXCR5
24	immunodeficiency	33.4	WAS, BMP6, BLZF1, PARP1, BCR, LGALS1
25	mediastinitis	33.2	PIGY, PIK3CG, VIM, MYC, MYB, PAX5
26	lymphoproliferative syndrome	32.9	SH2D1A, WAS, MYB, RAG1, BCL2, BCL6
27	lymphomatoid papulosis	32.8	IRF4, FASLG, FAS, CCR3, ALK, TNFRSF8
28	lymphoma, diffuse large cell	32.8	MYC, PAX5, BCL2, BCL2L1, BCL6, MS4A1
29	leukemia/lymphoma, t-cell	32.6	KITLG, RB1, MYC, MYCN, RAG1, PARP1
30	mycosis fungoides	32.6	BMI1, BCL2, BCL7A, CDKN2A, CD40LG, ITGA4
31	lymphosarcoma	32.4	MYB, BMI1, BCL2, BCL6, LGALS1, IL10
32	t-cell leukemia	32.0	PIK3CG, VAV1, MYC, MYB, RAG1, BLZF1
33	central nervous system lymphoma, primary	31.9	PIM1, PAX5, BCL6, MGMT, IGHM, CXCL13
34	lymphoplasmacytic lymphoma	31.8	PAX5, CD40LG, IGH@, F2
35	reticulosarcoma	31.7	PAX5, PARP1, BCL2, BCL6, CDKN1B, CCND3
36	mantle cell lymphoma	31.7	BMI1, BCL2, BCL6, MDM2, CCND1, CCNG1
37	hairy cell leukemia	31.6	BCL6, CD40, ITGA4, FCRL5, CCND1, IFNA1
38	primary malignant lymphoma	31.5	CDKN2A, IGHM, TP53, DNTT
39	thyroid lymphoma	31.4	BCL2, CDKN2A, IL7, FAS, CCNA2, TP53
40	hepatitis	31.1	CD58, FASLG, FAS, IFNA1, F2, TF
41	gastrointestinal lymphoma	31.0	BCL2, CDKN1A, CD44, CCND1, IFI27, CASP8
42	renal cell carcinoma	30.8	VIM, RASSF1, BIRC2, BIRC3, BIRC5, BCL2L1
43	neutropenia	30.7	WAS, KITLG, BLZF1, BIRC5, BCL2, CD40LG
44	severe combined immunodeficiency	30.5	RFXANK, KITLG, MYC, RAG1, BCL2, BCL6
45	combined immunodeficiency	30.4	RFXANK, KITLG, MYC, RAG1, BCL2, BCL6
46	panniculitis	30.3	BAX, FAS, IFNG, CASP3, TNF, TNFRSF8
47	sjogren's syndrome	30.2	KITLG, PARP1, BAX, CD59, CD40LG, CD40
48	richter's syndrome	30.2	BCR, CDKN1A, CDKN2A, CD38, IRF4, IGH@
49	cryoglobulinemia	30.2	BMP6, BIRC3, BCL2, BCR, CD27, CD40LG
50	hepatitis c	29.9	BCL6, JAK1, CD40LG, IL10, IL4, IL6R

Clinical features from OMIM: 113970

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 asparaginase, cyclophosphamide, cytarabine, cytarabine liposome, doxorubicin hydrochloride, irinotecan, irinotecan hydrochloride, mitoxantrone, mitoxantrone hydrochloride, thiotepa

Cell-based therapeutics:

Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 12171484, 19925877, 18489989

MalaCards organs/tissues related to burkitt's lymphoma:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Bone -> Bone Marrow -> Hematopoietic Stem Cells	Potential therapeutic candidate
2	Blood -> Peripheral Blood -> Mature B Cells	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to burkitt's lymphoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.6	PIGA, PIM1, SH2B2, SH2D1A, WAS, RBL1
2	respiratory system phenotype	MP:0005388	11.1	MYCN, RAG1, BID, BCL6, YY1, INPP5D
3	renal/urinary system phenotype	MP:0005367	10.8	WAS, MYCN, RAG1, RARA, BHLHE40, BCL2
4	embryogenesis phenotype	MP:0005380	10.8	PIGA, RBL2, RBL1, VIM, LMNB1, VAV1
5	limbs/digits/tail phenotype	MP:0005371	10.5	KITLG, RB1, RBL2, RBL1, MYCN, BMI1
6	endocrine/exocrine gland phenotype	MP:0005379	10.3	WAS, RBL2, RBL1, MYBL1, RAD23B, CDK6
7	craniofacial phenotype	MP:0005382	10.1	PIGA, KITLG, RBL1, LMNB1, MYCN, BMI1
8	pigmentation phenotype	MP:0001186	10.0	KITLG, RB1, MYC, RAG1, BCL2, BCL2L11
9	no phenotypic analysis	MP:0003012	9.8	RB1, RBL2, RBL1, MYC, MYBL2, BHLHE40
10	liver/biliary system phenotype	MP:0005370	9.6	RBL1, MYCN, MYB, RAG1, BID, BCL6
11	hearing/vestibular/ear phenotype	MP:0005377	9.6	KITLG, RB1, MYC, RAG1, RARA, PAX5
12	normal phenotype	MP:0002873	9.5	RBL2, RBL1, VAV1, MYC, MYB, MYBL1
13	growth/size phenotype	MP:0005378	9.3	PIGA, PIK3CG, PIM1, KITLG, RB1, RBL2
14	integument phenotype	MP:0010771	9.3	PIGA, PIK3CG, KITLG, RB1, RBL2, RBL1
15	digestive/alimentary phenotype	MP:0005381	9.2	PIGA, WAS, KITLG, RB1, RBL1, VAV1
16	immune system phenotype	MP:0005387	9.2	SH2D1A, WAS, RBL1, VIM, MYB, MYBL1
17	other phenotype	MP:0005395	9.2	RARA, CDKN2A, CD40LG, ITGB1, MME, ENTPD1
18	mortality/aging	MP:0010768	9.1	PIGA, KITLG, BTF3, RB1, RBL2, RBL1
19	cellular phenotype	MP:0005384	8.6	PIGA, PIK3CG, PIM1, SH2B2, SH2D1A, WAS
20	behavior/neurological phenotype	MP:0005386	8.5	PIGA, RB1, RBL1, VIM, MYCN, MYBL1
21	nervous system phenotype	MP:0003631	8.3	PIGA, KITLG, RB1, RBL2, RBL1, LMNB1
22	homeostasis/metabolism phenotype	MP:0005376	8.1	PIK3CG, SH2B2, WAS, KITLG, RB1, RBL2
23	reproductive system phenotype	MP:0005389	8.0	PIGA, RBL2, RBL1, VAV1, MYCN, MYBL1
24	skeleton phenotype	MP:0005390	7.9	PIGA, PIK3CG, WAS, KITLG, RB1, RBL2
25	adipose tissue phenotype	MP:0005375	7.4	RB1, RBL1, MYC, RAD23B, BCL2, CEBPB
26	vision/eye phenotype	MP:0005391	7.4	KITLG, RB1, RBL2, RBL1, VIM, MYCN
27	tumorigenesis	MP:0002006	6.9	PIGA, WAS, KITLG, RB1, RBL2, RBL1
28	cardiovascular system phenotype	MP:0005385	6.5	PIK3CG, KITLG, RB1, RBL2, RBL1, VIM
29	muscle phenotype	MP:0005369	6.2	PIK3CG, RB1, RBL2, RBL1, VIM, LMNB1

Articles related to burkitt's lymphoma:

(show top 50)    (show all 267)

id	Title	Authors	Year	Affiliating Genes
1	DLC-1 as a modulator of proliferation, apoptosis and migration in Burkitt's lymphoma cells. (20882354)	Feng M.... Chen Z.	2011	DLC1
2	Expression profiling of transcription factors in B- o r T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of P AX5 immunostaining as pan-Pre-B-cell marker. (20023257)	Nasr M.R.... Syrbu S.	2010	PAX5
3	Dose-intensified treatment of Burkitt lymphoma and B- cell lymphoma unclassifiable, (with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma) in young adults (<50 years): a compar ison of two adapted BFM protocols. (20201088)	Tauro S.... Holte H.	2010	CSF3
4	Endemic Burkitt's lymphoma as a polymicrobial disease : new insights on the interaction between Plasmodium falciparum and Epstein-Bar r virus. (19897039)	Chene A.... Bejarano M.T.	2009	MPP1
5	E2F1 expression is deregulated and plays an oncogenic role in sporadic Burkitt's lymphoma. (19406837)	Molina-Privado I.... Campanero M.R.	2009	E2F1
6	BIC is processed efficiently to microRNA-155 in Burkitt lymphoma cells. (18354490)	Zhang T.... Tam W.	2008	MIR155HG, MIR155
7	Identification of genes deregulated during serum-free medium adaptation of a Burkitt's lymphoma cell line. (18211290)	Zander L.... Bemark M.	2008	TF
8	CD40L-mediated inhibition of NF-kappaB in CA46 Burkitt lymphoma cells promotes apoptosis. (18661398)	Wang S.... Xu Z.	2008	NFKB1, CD40LG
9	ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. (18368067)	Ushmorov A.... Wirth T.	2008	MSC
10	Dok1 expression and mutation in Burkitt's lymphoma cell lines. (16338067)	Lee S.... Sylla B.S.	2007	DOK1
11	Caspase-independent killing of Burkitt lymphoma cell lines by rituximab. (16544097)	Daniels I.... Haynes A.P.	2006	AIFM1, CYCS
12	Down-regulation of expression of survivin and induct ion of apoptosis in the human Burkitt lymphomas cells by ligation of CD40-CD40L . (17199985)	Zhu F.B.... Lin Y.J.	2006	BIRC5
13	IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines. (16332968)	Kis L.L.... Klein E.	2006	IL10
14	Gene-hypermutated isoforms of MYC protein: Tumour-sup pressor P-53 protective-initiation of apoptosis that normally prevents Burkitt' s lymphoma tumorigenesis can be enhanced. (16413684)	Wiseman A.	2006	MYC
15	Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. (16104877)	Kobayashi M.... Ohnishi K.	2005	PTGS2, CASP9, BIRC5
16	Combined polymerase chain reaction methods to detect c-myc/IgH rearrangement in childhood Burkitt's lymphoma for minimal residual disease analysis. (15257933)	Busch K.... Harbott J.	2004	MYC
17	T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines. (12672960)	Kiss C.... Szekely L.	2003	TCL1A
18	Temporal ordering of caspase activation and substrate cleavage during antigen receptor-triggered apoptosis in Ramos-Burkitt lymphoma B cells. (12851674)	An S.... Knox K.	2003	LMNB1
19	High expression of apoptosis-regulating proteins in Burkitt's lymphomas. (11869962)	Pagnano K.B.... Saad S.T.	2002	BAX
20	T and B leukemic cell lines exhibit different requirements for cell death: correlation between caspase activation, DFF40/DFF45 expression, DNA fragmentation and apoptosis in T cell lines but not in Burkitt's lymphoma. (11960352)	Luciano F.... Auberger P.	2002	DFFA
21	VH gene analysis in sporadic Burkitt's lymphoma: somatic mutation and intraclonal diversity with special reference to the tumor cells involving germinal center. (11908722)	Isobe K.... Ito H.	2002	IGHM
22	PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells. (11783945)	Simons-Evelyn M.... Rapoport A.P.	2001	PBK
23	Differential effect of IL-4 and IL-13 on CD44 expression in the Burkitt's lymphoma B cell line BL30/B95-8 and in Epstein-Barr virus (EBV) transformed human B cells: loss of IL-13 receptors on Burkitt's lymphoma B cells. (11591117)	Gee K.... Kumar A.	2001	CD44, IL4, IL13RA2
24	c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. (10713166)	Gregory M.A.... Hann S.R.	2000	MYC
25	Molecular biology of Burkitt's lymphoma. (11054444)	Hecht J.L.... Aster J.C.	2000	MYC
26	Retinoic acid induces persistent, RARalpha-mediated anti-proliferative responses in Epstein-Barr virus-immortalized b lymphoblasts carrying an activated C-MYC oncogene but not in Burkitt's lymphoma cell lines. (10760826)	Cariati R.... Dolcetti R.	2000	RARA
27	Apoptosis and restriction of G(1)/S cell cycle by fenretinide in Burkitt's lymphoma mutu I cell line accessed with bcl-6 down-regulation. (11027625)	Hsieh T.... Wu J.M.	2000	BCL6
28	Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells. (10597239)	Barnouin K.... Lu X.	1999	CDKN1B, CCND3
29	Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. (10416592)	Corn P.G.... Herman J.G.	1999	TP73
30	Globotriaosyl ceramide modulates interferon-alpha-induced growth inhibition and CD19 expression in Burkitt's lymphoma cells. (11133022)	Maloney M.D.... Lingwood C.A.	1999	IFNAR1
31	V(H) gene analysis of Burkitt's lymphoma in children from north-western Iran. (9886329)	Chapman C.J.... Stevenson F.K.	1998	IGHM
32	No evidence of WT1 involvement in a Burkitt's lymphoma in a patient with Denys-Drash syndrome. (9681076)	Perotti D.... Radice P.	1998	WT1
33	G2 cell cycle arrest and apoptosis are induced in Burkitt's lymphoma cells by the anticancer agent oracin. (9000527)	Klucar J.... Al-Rubeai M.	1997	BCL2
34	Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines. (8847894)	Tani A.... Ohno H.	1996	BCL2
35	Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma. (8690509)	Sangfelt O.... GrandAcr D.	1996	IFNA1
36	Increased rate of transcription contributes to elevat ed expression of the mutant p53 gene in Burkitt's lymphoma cells. (8603415)	BA!lint E.... Reisman D.	1996	TP53
37	Functional analysis of Burkitt's lymphoma mutant c-Myc proteins. (8621409)	Smith-SA... Bernards R.	1996	MYC
38	Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (8605326)	Zani V.J.... Dyer M.J.S.	1996	BCL7A, BCL7B, BCL7C
39	The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma. (7768941)	Ji L.... Boxer L.M.	1995	NME2
40	Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines. (8108117)	Albert T.... Eick D.	1994	MYC
41	The Epstein-Barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in Burkitt lymphoma lines. (8157362)	Nakagomi H.... Masucci M.G.	1994	MPP1
42	Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. (8220424)	Bhatia K.... Magrath I.	1993	MYC
43	Induced and down-regulated proteins in the human cultured hairy cell leukemia line JOK-1 and the Burkitt's lymphoma cell line Daudi during incubation with interferon-alpha: a kinetic study. (1431314)	Madsen P.S.... Hokland M.	1992	IFNA1
44	A novel mutation in the p53 gene in a Burkitt's lymphoma cell line. (1303181)	Bhatia K.... Magrath I.T.	1992	TP53
45	c-myc hypermutation in Burkitt's lymphoma. (1297477)	Johnston J.M.... Carroll W.L.	1992	MYC
46	p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas. (1437144)	Duthu A.... May P.	1992	TP53
47	Two antisense promoters in the immunoglobulin mu-switch region drive expression of c-myc in the Burkitt's lymphoma cell line BL67. (1620543)	Apel T.W.... Eick D.	1992	MYC, IGHM, IGH@
48	c-myc hypermutation is ongoing in endemic, but not all Burkitt's lymphoma. (1932754)	Johnston J.M.... Carroll W.L.	1991	MYC
49	A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas. (3277717)	Hann S.R.... Eisenman R.N.	1988	MYC
50	High-resolution analysis of chromosome markers in Burkitt lymphoma cell lines. (7061176)	Zhang S.... Klein G.	1982	B2MR

Genes related to burkitt's lymphoma according to GeneCards:

(show top 50)    (show all 270)

id	Symbol	Description	Score	GeneCards Section Context
1	CXCR5	chemokine (C-X-C motif) receptor 5	11.1	Summaries, Orthologs, Functions, Domains & Families (show all 7 sections) Aliases & Descriptions, Publications, Expressions
2	CXCL13	chemokine (C-X-C motif) ligand 13	11.1	Publications, Aliases & Descriptions, Summaries
3	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.1	Summaries, Publications
4	BCL7A	B-cell CLL/lymphoma 7A	11.1	Summaries, Functions, Publications
5	BCL7B	B-cell CLL/lymphoma 7B	11.1	Summaries, Publications
6	BCL7C	B-cell CLL/lymphoma 7C	11.1	Publications, Summaries
7	AICDA	activation-induced cytidine deaminase	11.1	Aliases & Descriptions, Publications
8	BVR1	Burkitt lymphoma variant rearranging region 1	11.1	Aliases & Descriptions, Publications
9	SH2B2	SH2B adaptor protein 2	11.0	Summaries
10	WNT10A	wingless-type MMTV integration site family, member 10A	11.0	Summaries
11	SOX11	SRY (sex determining region Y)-box 11	11.0	Publications
12	POLM	polymerase (DNA directed), mu	11.0	Publications
13	IGHM	immunoglobulin heavy constant mu	11.0	Publications
14	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
15	GALK1	galactokinase 1	11.0	Publications
16	MYBL1	v-myb myeloblastosis viral oncogene homolog (avian)-like 1	11.0	Publications
17	MNDA	myeloid cell nuclear differentiation antigen	11.0	Publications
18	MPP1	membrane protein, palmitoylated 1, 55kDa	11.0	Publications
19	IL13RA2	interleukin 13 receptor, alpha 2	11.0	Publications
20	BCL6	B-cell CLL/lymphoma 6	11.0	Publications
21	SH2D1A	SH2 domain containing 1A	11.0	Publications
22	CCNG1	cyclin G1	11.0
23	POLI	polymerase (DNA directed) iota	11.0
24	NME2	NME/NM23 nucleoside diphosphate kinase 2	11.0	Publications
25	CR2	complement component (3d/Epstein Barr virus) receptor 2	11.0	Publications
26	NR4A1	nuclear receptor subfamily 4, group A, member 1	11.0	Publications
27	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
28	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications
29	CD27	CD27 molecule	11.0
30	IL10RA	interleukin 10 receptor, alpha	11.0
31	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.0
32	TRADD	TNFRSF1A-associated via death domain	11.0
33	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	11.0
34	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0
35	RAG1	recombination activating gene 1	11.0
36	BCL2L11	BCL2-like 11 (apoptosis facilitator)	11.0	Publications
37	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
38	DIABLO	diablo, IAP-binding mitochondrial protein	11.0	Publications
39	TERF2	telomeric repeat binding factor 2	11.0
40	TLR9	toll-like receptor 9	11.0	Publications
41	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
42	BMI1	BMI1 polycomb ring finger oncogene	11.0
43	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
44	CXCR1	chemokine (C-X-C motif) receptor 1	11.0
45	IL12RB2	interleukin 12 receptor, beta 2	11.0
46	LCK	lymphocyte-specific protein tyrosine kinase	11.0	Publications
47	LGALS1	lectin, galactoside-binding, soluble, 1	11.0	Publications
48	CDC25C	cell division cycle 25 homolog C (S. pombe)	11.0
49	CXCL9	chemokine (C-X-C motif) ligand 9	11.0
50	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	11.0	Publications

Pathways related to burkitt's lymphoma according to GeneDecks:

(show top 50)    (show all 341)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and Autophagy3	12.0	PIM1, LMNB1, MYC, MYCN, BID, BIRC2
2	Lymphocyte Signaling3	11.5	PIM1, SH2D1A, KITLG, BMI1, RAG1, PAX5
3	Pancreatic cancer20	10.9	CDK6
4	Apoptosis and survival FAS signaling cascades10	10.9	LMNB1, BID, BIRC2, PARP1, BCL2, BCL2L11
5	Apoptosis and survival_FAS signaling cascades41	10.9	LMNB1, BID, BIRC2, PARP1, BCL2, BCL2L11
6	Hematopoietic cell lineage20	10.8	KITLG, MS4A1, CD24, CD59, CD44, CD55
7	Jak-STAT signaling pathway20	10.7	PIK3CG, PIM1, MYC, BCL2L1, JAK1, IL10
8	Immune response BCR pathway10	10.7	VAV1, BCL2L1, BCL6, INPP5D, FCGR2B, MAPK1
9	Immune response_BCR pathway41	10.7	VAV1, BCL2L1, BCL6, INPP5D, FCGR2B, MAPK1
10	Apoptosis and survival Apoptotic TNF-family pathways10	10.6	BID, BIRC2, BCL2, BCL2L1, BAX, XIAP
11	Cytokine-cytokine receptor interaction20	10.6	KITLG, CD27, CD40LG, CD40, IL10, IL10RA
12	p38 Signaling36	10.4	KITLG, BMP6, BCL2, ZAP70, LCK, BAX
13	Chemokine signaling pathway20	10.4	PIK3CG, WAS, VAV1, MAPK1, MAP2K1, CCR1
14	Apoptosis and survival_TNFR1 signaling pathway41	10.3	BID, BIRC2, BIRC3, BCL2, BAX, XIAP
15	Akt Signaling36	10.2	PIK3CG, ITGAL, IL10, IL10RA, IL4, IL4R
16	Apoptosis and survival TNFR1 signaling pathway10	10.2	BID, BIRC2, BIRC3, BAX, XIAP, CFLAR
17	Apoptosis and survival_Apoptotic TNF-family pathways41	10.2	BID, BIRC2, BCL2, BCL2L1, BAX, XIAP
18	Measles20	10.2	PIK3CG, SH2D1A, JAK1, CDK6, CDKN1B, CDK4
19	STAT3 Pathway36	10.2	PIM1, MYC, BMP6, BCL2, BAX, CDKN1A
20	Fas Signaling36	10.1	RB1, LMNB1, BID, BIRC2, BIRC3, CFLAR
21	Tec Kinases Signaling36	10.0	WAS, KITLG, VAV1, BMP6, BCL2, BAX
22	Apoptosis Signaling Pathways37	10.0	BID, BIRC2, BIRC3, BIRC5, BCL2, BCL2L1
23	p53 Signaling36	9.9	BCL2, BAX, CDKN1A, CDK4, MDM2, MAPK8
24	Antioxidant Action of Vitamin-C36	9.9	KITLG, BMP6, BCL2, BAX, IL10, IL10RA
25	Signal transduction_AKT signaling41	9.9	MYC, BCL2L1, BCL2L11, BAX, CDKN1A, CDKN1B
26	IL-6 Pathway36	9.9	PIM1, BMP6, BAX, IL10, IL4, IL6R
27	Apoptosis20	9.9	PIK3CG, BID, BIRC2, BIRC3, BCL2, BCL2L1
28	Natural killer cell mediated cytotoxicity20	9.8	PIK3CG, SH2D1A, VAV1, BID, ZAP70, LCK
29	PEDF Induced Signaling36	9.8	BMP6, BCL2, BCL2L1, BAX, CFLAR, IL10
30	Immune response Role of integrins in NK cells cytotoxicity10	9.7	VAV1, ITGA4, ITGAL, ITGB1, FASLG, MAPK1
31	Cell cycle20	9.6	RB1, RBL2, RBL1, MYC, CDK6, CDKN1A
32	p53 signaling pathway20	9.6	BID, BAX, CDK6, CDKN1A, CDKN2A, CDK4
33	Molecular Mechanisms of Cancer36	9.5	PIK3CG, KITLG, RB1, RBL1, MYC, BMP6
34	Apoptosis through Death Receptors36	9.5	BID, BIRC2, BIRC3, BCL2, BAX, CFLAR
35	Apoptosis and survival Caspase cascade10	9.5	LMNB1, BID, PARP1, BAX, XIAP, FASLG
36	Apoptosis and survival_Caspase cascade41	9.5	LMNB1, BID, PARP1, BAX, XIAP, FASLG
37	Apoptotic Pathways Triggered By HIV136	9.4	BID, BIRC2, BIRC3, BCL2, BCL2L1, BAX
38	Influenza A20	9.1	PIK3CG, JAK1, FASLG, MAPK8, MAPK1, MAP2K1
39	Chronic myeloid leukemia20	9.1	PIK3CG, RB1, MYC, BCL2L1, BCR, CDK6
40	MIF Regulation of Innate Immune Cells36	9.0	BMP6, BCL2, BAX, IL10, IL4, IL7
41	T cell receptor signaling pathway20	9.0	PIK3CG, VAV1, ZAP70, LCK, CD40LG, CDK4
42	Pathways in cancer20	9.0	PIK3CG, RB1, MYC, RARA, RASSF1, BIRC2
43	JAK-STAT Pathway36	8.9	KITLG, MYC, BMP6, BCL2, BAX, JAK1
44	Cellular Apoptosis Pathway36	8.9	KITLG, BMP6, BID, BIRC2, BCL2, BCL2L1
45	Small cell lung cancer20	8.8	PIK3CG, RB1, MYC, BIRC2, BIRC3, BCL2
46	Tuberculosis20	8.8	RFXANK, BID, BCL2, BAX, CEBPB, JAK1
47	Toxoplasmosis20	8.8	PIK3CG, BIRC2, BIRC3, BCL2, BCL2L1, XIAP
48	Glioma20	8.6	PIK3CG, RB1, CDK6, CDKN1A, CDKN2A, CDK4
49	Colorectal Cancer Metastasis36	8.0	MYC, BIRC5, BCL2L1, BAX, JAK1, CDKN1A
50	Pancreatic Adenocarcinoma36	8.0	KITLG, RB1, BMP6, BIRC5, BCL2, BCL2L1

Compounds related to burkitt's lymphoma according to GeneDecks:

(show top 50)    (show all 451)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	14.8	PIM1, SH2D1A, WAS, KITLG, RB1, RBL1
2	glucose32	11.4	BID, LGALS1, XIAP, CFLAR, MPP1, CDK4
3	phenylalanine32	11.1	VAV1, BLZF1, BCR, ZAP70, LCK, JAK1
4	ionomycin32	11.1	PIM1, WAS, LMNB1, VAV1, RAG1, LCK
5	phosphotyrosine32	11.0	PIK3CG, SH2B2, SH2D1A, VAV1, BLZF1, BCR
6	alanine32	10.9	PIM1, KITLG, RBL2, RBL1, MYC, MYB
7	vincristine32 34 9 9	13.9	MYCN, BCL6, ITGA4, MGMT, ANXA5, IFNA1
8	pge232	10.8	MME, FCER2, FASLG, MAP2K1, CCL3, GPX4
9	leucine32	10.8	RB1, RBL1, VIM, VAV1, MYC, MYCN
10	proline32	10.7	PIM1, WAS, VIM, RAD23B, LCK, JAK1
11	calcitriol32 42 9 18 9	14.7	KITLG, RB1, MYC, BMP6, RARA, PAX5
12	estradiol32 9 18 9	13.7	KITLG, RB1, VIM, MYB, BIRC5, XIAP
13	atp32	10.6	PIM1, WAS, RB1, RBL2, RBL1, BLZF1
14	nitric oxide32 9 18 9	13.4	KITLG, RB1, MYCN, BMP6, BID, BIRC5
15	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	10.4	MYC, PARP1, BCL2, BCL2L1, BAX, CD40
16	cholesterol32 9 18 9	13.2	KITLG, RB1, VAV1, BLZF1, BIRC5, PAX5
17	melphalan32 9 9	12.1	BIRC5, BCL2L1, BCL2L11, MGMT, IL4, MCL1
18	superoxide32 18	10.9	KITLG, RB1, VAV1, BLZF1, BIRC5, LGALS1
19	cytarabine32 34 9 9	12.8	KITLG, RB1, VIM, MYC, BCL2, BCL2L1
20	ceramide32	9.8	RB1, BID, BCL2L1, BCL2L11, LGALS1, XIAP
21	17-(allylamino)-17-demethoxygeldanamycin32	9.8	BIRC5, CDK6, CDKN1A, CDC25C, CDK4, ANXA5
22	progesterone32 42 9 18 9	13.8	RB1, MYB, RARA, BIRC5, BCL2, CEBPB
23	2-methoxyestradiol32 18	10.7	BID, PAX5, BCL2, BCL2L1, BAX, CDKN1A
24	matrigel32	9.7	PIK3CG, RB1, VIM, BMP6, BCL2L1, LGALS1
25	cysteine32	9.6	LMNB1, MYB, RAG1, RARA, BLZF1, PARP1
26	adp32 18	10.5	PIK3CG, PIM1, WAS, BLZF1, PBK, BCL2L1
27	c2ceramide32	9.5	PIK3CG, PARP1, BCL2L1, BAX, MAPK8, CASP3
28	thapsigargin32 42	10.5	PIK3CG, MYB, BLZF1, BCL2, BCL2L1, BCR
29	agar32	9.5	KITLG, RB1, VIM, MYCN, RARA, RASSF1
30	rottlerin32 42	10.4	PIK3CG, PARP1, XIAP, CDK6, CD40LG, IL6R
31	carboplatin32 34 9 9	12.4	KITLG, RB1, BID, PARP1, BCL2, XIAP
32	arsenite32 18	10.4	PIK3CG, MYC, RARA, BIRC2, BIRC5, PARP1
33	lactate32	9.4	KITLG, VIM, MYCN, BMP6, BLZF1, BIRC5
34	geldanamycin32 9 9	11.4	PIK3CG, PIM1, BIRC5, PARP1, BCL2L1, LCK
35	sulindac32 9 9	11.3	BIRC5, BCL2, BCL2L1, BAX, XIAP, CDKN1A
36	tgf beta132	9.3	KITLG, RBL2, RBL1, VIM, BMP6, RARA
37	adpribose32	9.1	PIK3CG, RB1, LMNB1, BID, BIRC5, PARP1
38	thymidylate32	9.1	RB1, VIM, MYBL2, BIRC5, BCL2, BCL2L1
39	flavopiridol32 9 9	11.1	PIK3CG, RB1, RBL1, BID, BIRC5, PARP1
40	paraffin32	9.0	KITLG, RB1, VIM, MYC, MYCN, RARA
41	n acetylcysteine32	8.9	BIRC5, CEBPB, JAK1, CDKN1A, CDKN1B, CDKN2A
42	suberoylanilide hydroxamic acid32	8.9	MYC, BID, BIRC5, PARP1, BCL2, BCL2L1
43	herbimycin a32 42	9.8	PIK3CG, KITLG, VAV1, MYC, BMP6, LCK
44	thymidine32 18	9.8	KITLG, RB1, RBL1, MYC, MYB, MYBL2
45	sulforaphane32	8.7	PIK3CG, RB1, PARP1, CDKN1A, CDC25C, MGMT
46	5-aza-2deoxycytidine32	8.5	KITLG, VIM, MYC, BMP6, RASSF1, CFLAR
47	tamoxifen32 34 9 9	11.5	VIM, MYC, BMP6, RARA, BIRC5, BCL2
48	ciglitazone32	8.3	RARA, PARP1, BCL2L1, BAX, CDKN1A, CDKN1B
49	adriamycin32	8.1	RB1, VIM, MYC, MYCN, BIRC2, BIRC3
50	pd 98,05932	8.0	PIK3CG, KITLG, RB1, MYC, BMP6, RARA

Cellular components related to burkitt's lymphoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.7	CCR3, GPER, IFNAR1, ICAM1, ICAM2, ALK
2	external side of plasma membrane	GO:009897	10.5	CCR1, IFNG, ICAM1, TNF, CR2, CXCL9
3	death-inducing signaling complex	GO:031264	10.4	RIPK1, CASP8, FAS, CFLAR
4	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.3	CCND1, CCND3, CCND2, CDK4, CDKN1A, CDK6
5	nucleolus	GO:005730	10.2	NFKB1, NFATC2, DAP3, PTK2B, TERF2, TP53
6	cell surface	GO:009986	10.1	ALPP, HSPD1, TNF, PLAT, CXCR2, CXCR4
7	membrane raft	GO:045121	9.9	TNF, SLC6A4, RIPK1, LYN, RGS16, CASP8
8	cytoplasm	GO:005737	9.5	DNTT, TLR9, TSG101, TSC22D3, ELF1, ACP1
9	plasma membrane	GO:005886	9.1	EZR, CADM1, CASP3, CARD11, CAMK2G, AKT1
10	nucleus	GO:005634	9.1	TRADD, CCNA2, MAP2K1, MAZ, MAPK1, MAF
11	extracellular space	GO:005615	8.6	F2, HSPG2, HSPD1, TNF, TNFSF10, TNFSF13B
12	nucleoplasm	GO:005654	8.2	NR4A1, TERF2, TP53, HNRNPA1, AKT1, CAMK2G
13	cytosol	GO:005829	8.0	BIRC2, BID, USP18, VAV1, VIM, WAS

Biological processes related to burkitt's lymphoma according to GeneDecks:

(show top 50)    (show all 85)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	11.4	BMP6, WAS, VAV1, IL4, RAG1, ZAP70
2	cellular response to mechanical stimulus	GO:071260	11.0	MAPK8, FAS, ITGB1, GADD45A, CASP8, TNFRSF10A
3	activation of pro-apoptotic gene products	GO:008633	10.9	AKT1, TRADD, TNFRSF10B, TNFSF10, RIPK1, CASP8
4	B cell differentiation	GO:030183	10.9	RAG1, IL4, BCL6, CD40LG, ITGA4, ITGB1
5	leukocyte cell-cell adhesion	GO:007159	10.9	ICAM1, SYK, ITGB1, ITGAL, EZR, ITGA4
6	leukocyte migration	GO:050900	10.9	CD58, LCK, ITGAL, ITGB1, INPP5D, F2
7	signal transduction	GO:007165	10.9	IGF1, CCND3, MAP2K1, MAPRE2, ANXA5, FAS
8	positive regulation of B cell proliferation	GO:030890	10.8	CD38, NFATC2, CD40LG, CDKN1A, BCL6, BCL2
9	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.8	LGALS1, BIRC2, BIRC3, CFLAR, RIPK1, TLR9
10	induction of apoptosis by extracellular signals	GO:008624	10.7	CFLAR, FAS, IFI27, TNF, FASLG, CD38
11	release of cytochrome c from mitochondria	GO:001836	10.7	TP53, CASP3, BAX, BCL2L1, BCL2, BID
12	regulation of cell cycle	GO:051726	10.7	PTGS2, ID3, ITGB1, CDK4, CDC25C, BAX
13	induction of apoptosis via death domain receptors	GO:008625	10.7	DEDD2, DIABLO, BID, TNFRSF10A, TNF, CASP3
14	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.6	PYCARD, CDKN1B, BAX, LCK, BCL2L11, MYC
15	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.6	ALK, CD40, ICAM1, IL6R, CARD11, RIPK1
16	cytokine-mediated signaling pathway	GO:019221	10.6	CCR1, IL6R, IL13RA2, JAK1, ICAM1, IL12RB2
17	B cell receptor signaling pathway	GO:050853	10.5	SYK, LYN, MNDA, PTPN6, NFATC2, CD38
18	tumor necrosis factor-mediated signaling pathway	GO:033209	10.5	AIM2, TRADD, TNF, TNFRSF8, PYCARD, STAT1
19	apoptotic DNA fragmentation	GO:006309	10.5	DFFA, MYC, BAX, CDKN2A, CASP3, AIFM1
20	innate immune response	GO:045087	10.4	CASP8, AIM2, PYCARD, CR2, NFKB1, NFKBIA
21	negative regulation of B cell proliferation	GO:030889	10.4	LYN, CASP3, IL10, INPP5D, MNDA, CDKN2A
22	cell surface receptor signaling pathway	GO:007166	10.4	F2, CXCR1, PTK2B, DOK1, TNFRSF10B, IL12RB2
23	neuron apoptotic process	GO:051402	10.4	AIFM1, CASP3, TP53, FAS, BAX, BCL2
24	regulation of apoptotic process	GO:042981	10.4	LGALS1, IL6R, ALK, TNFRSF10B, CASP3, CARD11
25	positive regulation of neuron apoptotic process	GO:043525	10.4	BCL2L11, CASP3, BAX, FASLG, NQO1, CCL3
26	virus-host interaction	GO:019048	10.4	CXCR4, ITGB1, HNRNPA1, CD46, CDC25C, CFLAR
27	positive regulation of cell proliferation	GO:008284	10.3	MDM2, BIRC5, RARA, MYC, IGF1, TNFSF13B
28	T cell activation	GO:042110	10.3	IFNAR1, ADA, HSPD1, IRF4, ZAP70, PIK3CG
29	response to DNA damage stimulus	GO:006974	10.3	CDKN1A, BAX, YY1, XIAP, TP73, MNDA
30	induction of apoptosis	GO:006917	10.2	TRADD, TNF, TNFRSF10A, TNFSF10, RIPK1, STAT1
31	positive regulation of apoptotic process	GO:043065	10.1	TNFSF10, INPP5D, ABL1, ITGB1, MNDA, BAX
32	apoptotic mitochondrial changes	GO:008637	10.1	CDKN2A, AKT1, DAP3, BCL2L1, BID, BAX
33	induction of apoptosis by intracellular signals	GO:008629	10.0	XIAP, CDKN1A, BAX, BCL2L11, BCL2L1, MYC
34	anti-apoptosis	GO:006916	9.9	XIAP, CFLAR, CEBPB, BCL2, CD27, BIRC3
35	inflammatory response	GO:006954	9.9	GAL, IFI16, CXCR2, CAMK1D, AKT1, AIM2
36	G1 phase of mitotic cell cycle	GO:000080	9.8	RBL2, E2F1, RB1, CCND1, CDK6, CDK4
37	nerve growth factor receptor signaling pathway	GO:048011	9.8	VAV1, BCL2L11, CDKN1B, MDM2, MAPK8, MAPK1
38	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	HGF, SYK, PTK2B, TP53, IGF1, ITGB1
39	negative regulation of transcription, DNA-dependent	GO:045892	9.6	TSG101, DEDD2, HDAC2, E2F1, RB1, SIN3A
40	negative regulation of apoptotic process	GO:043066	9.6	HDAC2, CASP3, HSPD1, CCNG1, MAPK8, MDM2
41	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.6	TNF, TP53, ID3, IFNG, IFI16, MDM2
42	response to toxin	GO:009636	9.5	SLC6A4, NQO1, BAX, CDKN1A, BCL2, MGMT
43	cell cycle arrest	GO:007050	9.4	RASSF1, CDK6, CDKN1A, CDKN1B, MYC, MAP2K1
44	Ras protein signal transduction	GO:007265	9.2	DOK1, TP53, IGF1, CDKN2A, RB1, RASSF1
45	blood coagulation	GO:007596	9.1	PTPN11, PTPN6, PLAT, PLCG1, ABL1, HBB
46	apoptotic process	GO:006915	9.1	GADD45A, E2F1, RIPK1, CXCR4, CXCR3, CXCR2
47	platelet activation	GO:030168	9.0	ENTPD1, MAPK1, IGF1, F2, AKT1, HGF
48	positive regulation of transcription, DNA-dependent	GO:045893	9.0	MYC, NFATC2, TNF, TP73, TP53, IGF1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	RBL1, AKT1, NFATC2, BMP6, MYB, MYCN
50	response to drug	GO:042493	8.2	LCK, TNF, GAL, BCL2, LGALS1, CDKN1A

Molecular functions related to burkitt's lymphoma according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein heterodimerization activity	GO:046982	10.9	ITGB1, MCL1, MAF, TP53, TAP1, CXCL13
2	BH3 domain binding	GO:051434	10.8	MCL1, BAX, BCL2L1, BCL2
3	signal transducer activity	GO:004871	10.8	TRADD, PTK2B, STAT3, STAT1, CXCR2, GNG8
4	non-membrane spanning protein tyrosine kinase activity	GO:004715	10.6	LYN, SYK, ABL1, PTK2B, JAK1, LCK
5	C-X-C chemokine receptor activity	GO:016494	10.6	CXCR5, CXCR4, CXCR3, CXCR2
6	sequence-specific DNA binding	GO:043565	10.5	SPIB, NR4A1, NFATC2, WT1, EGR1, ELF1
7	tumor necrosis factor receptor binding	GO:005164	10.3	STAT1, TNFSF13B, TNFSF10, TNF, CASP8, FASLG
8	protein kinase binding	GO:019901	10.0	CCND3, CCND1, TP53, TP73, PTPN6, SYK
9	sequence-specific DNA binding transcription factor activity	GO:003700	9.9	NFKB1, NFATC2, SPIB, TP73, TP53, ID3
10	identical protein binding	GO:042802	9.9	AKT1, TRADD, TP53, TP73, TNF, NFKBIA
11	ubiquitin protein ligase binding	GO:031625	9.9	LYN, CXCR4, TF, TSG101, NFKBIA, TP53
12	transcription factor binding	GO:008134	9.8	TP53, TP73, TNFRSF10A, NFKBIA, STAT3, PRKDC
13	DNA binding	GO:003677	9.8	TSG101, ABL1, EGR1, NFATC2, NR4A1, TP53
14	cytokine activity	GO:005125	9.5	IFNG, TNF, TNFSF10, TNFSF13B, CXCL9, CSF3
15	enzyme binding	GO:019899	9.2	PTGS2, NFKBIA, STAT1, PRKDC, CSF3, LYN
16	ATP binding	GO:005524	9.2	AGK, ABL1, DICER1, PTK2B, TP53, AKT1
17	protein binding	GO:005515	8.0	IGF1, TNFRSF10B, TNFSF10, TNFSF13B, DOK1, TERF2