BL
MCID: BRK003
MIFTS: 78

Burkitt's Lymphoma (BL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Burkitt's Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 46OMIM, 32MalaCards
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MedlinePlus:33 Lymphoma is a cancer of a part of the immune system called the lymph system. there are many types of lymphoma. one type is hodgkin disease. the rest are called non-hodgkin lymphomas. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors don't know why a person gets non-hodgkin lymphoma. you are at increased risk if you have a weakened immune system or have certain types of infections. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. targeted therapy uses substances that attack cancer cells without harming normal cells. biologic therapy boosts your body's own ability to fight cancer. if you don't have symptoms, you may not need treatment right away. this is called watchful waiting. nih: national cancer institute

MalaCards: Burkitt's Lymphoma, also known as burkitt lymphoma, is related to hodgkin's lymphoma and leukemia. An important gene associated with Burkitt's Lymphoma is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways is IL4-mediated signaling events. The drugs cyclophosphamide and asparaginase and the compounds peg-10 and cytidine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

NIH Rare Diseases:42 Burkitt lymphoma (bl) is a rare, aggressive form of b-cell non-hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. it is more common in males than females. three forms exist: one endemic to africa that is linked to the epstein barr virus (ebv); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with hiv infection. bl can also develop in the ear, nose, throat and more rarely in other locations. signs and symptoms may differ depending on the form of bl and the organs or body systems affected. the exact cause of the condition is not known. treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. last updated: 6/26/2012

Description from OMIM:46 113970

Aliases & Classifications for Burkitt's Lymphoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
burkitt lymphoma:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

burkitt's lymphoma 8 42 30
burkitt lymphoma 8 9 42 22 46 44 48 60
lymphoma 8 10 44 33 60
small non-cleaved cell lymphoma, burkitt's type 8
burkitt's lymphoma of unspecified site 8
malignant lymphoma, burkitt's type 8
lymphoma, small noncleaved-cell 60
small non-cleaved cell lymphoma 48
burkitt's lymphoma - disorder 8
burkitt lymphoma/leukaemia 8
burkitt's lymphoma nos 8
burkitt's tumor nos 8
lymphoid neoplasm 44
burkitts lymphoma 10
burkitt's tumour 8
burkitt's tumors 8
lymphatic cancer 60
lymphoid cancer 8
burkitt's tumor 8
bl 42


External Ids:

Disease Ontology8 DOID:8584, DOID:0060058
ICD9CM27 200.2
OMIM46 113970
MESH via Orphanet35 D002051, D008228
ICD10 via Orphanet26 C83.7
SNOMED-CT via Orphanet57 118617000, 22197008, 397400006 77381001, more
UMLS via Orphanet61 C0006413, C0079770
ICD1025 C83.7

Related Diseases for Burkitt's Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Burkitt's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1108)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma31.9AICDA, BCL6, SH2D1A, TCL1A, IGHM, MPP1
2leukemia31.7CXCR5, TCL1A, BCL6, AICDA, MYC, SH2D1A
3mantle cell lymphoma31.7SOX11
4non-hodgkin lymphoma31.7AICDA, CXCR5, SH2D1A, TCL1A, BCL6, MYC
5gastric lymphoma31.6BCL6
6central nervous system lymphoma31.5BCL6
7intraocular lymphoma31.2CXCR5
8chronic lymphocytic leukemia31.1BCL6, TCL1A, IGHM, AICDA, CXCR5
9myeloma30.9TCL1A, BCL6, CXCR5, MYC, IGHM
10hepatitis b30.8IGHM
11rheumatoid arthritis30.5IGHM, CXCR5
12plasmacytoma30.4BCL6, MYC, AICDA, CXCR5
13central nervous system lymphoma, primary30.3CXCR5, BCL6, IGHM, CXCL13
14ataxia telangiectasia30.3AICDA, TCL1A
15angioimmunoblastic t-cell lymphoma30.3CXCL13, BCL6
16follicular lymphoma30.3MYC, CXCR5, TCL1A, IGHM, BCL6, AICDA
17prolymphocytic leukemia30.2TCL1A, MYC
18b-cell lymphomas30.2MYC, CXCL13, AICDA, BCL6, CXCR5, TCL1A
19peripheral t-cell lymphoma30.1TCL1A, BCL6, CXCL13
20malt lymphoma30.1IGHM, BCL6, CXCL13, CXCR5
21lymphoma, diffuse large cell29.9MYC, BCL6
22b-cell chronic lymphocytic leukemia29.9BCL6, IGHM, AICDA, TCL1A
23lymphoma aidsrelated29.9MYC, BCL6, TCL1A
24precursor b-cell acute lymphoblastic leukemia29.6CXCL13, MYC, CXCR5
25agammaglobulinemia29.6IGHM, SH2D1A
26common variable immune deficiency29.6SH2D1A, AICDA
27ipex syndrome29.4AICDA, BCL6, IGHM, SH2D1A, MPP1, CXCR5
28diffuse large b-cell lymphoma11.2
29anaplastic large cell lymphoma11.1
30cutaneous t cell lymphoma11.1
31adult lymphoma11.0
32t-cell leukemia11.0
33marginal zone b-cell lymphoma11.0
34bone lymphoma10.9
35adult t-cell leukemia10.9
36breast lymphoma10.9
37thyroid lymphoma10.8
38splenic marginal zone lymphoma10.8
39thyroiditis10.8
40gastrointestinal lymphoma10.8
41mediastinitis10.8
42acute leukemia10.8
43pediatric lymphoma10.8
44lymphoblastic leukemia10.7
45cerebral lymphoma10.7
46hepatitis10.7
47composite lymphoma10.7
48lymphoplasmacytic lymphoma10.7
49panniculitis10.7
50sarcoma10.7

Graphical network of the top 20 diseases related to Burkitt's Lymphoma:



Diseases related to burkitt's lymphoma

Clinical Features for Burkitt's Lymphoma

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Sources:
46OMIM
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Clinical features from OMIM:

113970

Clinical synopsis from OMIM:

113970

Drugs & Therapeutics for Burkitt's Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Burkitt's Lymphoma

Drug clinical trials:

Search ClinicalTrials for Burkitt's Lymphoma

Search NIH Clinical Center for Burkitt's Lymphoma

Search CenterWatch for Burkitt's Lymphoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Burkitt's Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Burkitt's Lymphoma

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22GTR
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Genetic tests related to Burkitt's Lymphoma:

id Genetic test Affiliating Genes
1 Burkitt Lymphoma22

Anatomical Context for Burkitt's Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Burkitt's Lymphoma:

32
B cells, T cells, Lymph node, Testes, Bone, Breast, Bone marrow, Ovary, Colon, Kidney, Tongue, Thyroid, Liver, Small intestine, Pancreas, B lymphoblasts, Heart, Endothelial, Brain, Appendix

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Burkitt's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Burkitt's Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Burkitt's Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.5MPP1, SH2B2, SH2D1A, IGHM, AICDA, POLM
2MP:000538711.5BCL6, SOX11, MPP1, SH2B2, SH2D1A, IGHM
3MP:000539711.2AICDA, IGHM, SH2D1A, SH2B2, SOX11, POLM

Publications for Burkitt's Lymphoma

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50PubMed
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Articles related to Burkitt's Lymphoma:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
MYC Negative Rectal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Burkitt's Lymphoma in an Immunocompetent Patient. (23365776)
2013
2
An unusual intradural involvement secondary to Burkitt's lymphoma. (22962368)
2012
3
TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism. (22717578)
2012
4
Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets. (22985630)
2012
5
Selective cytotoxicity of amidinopiperidine based compounds towards Burkitt's lymphoma cells involves proteasome inhibition. (22860040)
2012
6
The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. (20503272)
2011
7
Proteasome inhibitors induce the presentation of an Epstein-Barr virus nuclear antigen 1-derived cytotoxic T lymphocyte epitope in Burkitt's lymphoma cells. (21342184)
2011
8
Clinical characteristics, treatment and outcome of childhood Burkitt's lymphoma at the Uganda Cancer Institute. (22047912)
2011
9
Selective killing of Burkitt's lymphoma cells by mBAFF-targeted delivery of PinX1. (21102426)
2011
10
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response. (20723265)
2010
11
Diagnosis in childhood abdominal Burkitt's lymphoma. (20499283)
2010
12
Epstein-Barr virus lytic cycle activation alters proteasome subunit expression in Burkitt's lymphoma cells. (20536393)
2010
13
DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma. (20551953)
2010
14
BimL upregulation induced by BCR cross-linking in BL41 Burkitt's lymphoma results from a splicing mechanism of the BimEL mRNA. (19332026)
2009
15
Bilateral mental nerve neuropathy as the sole presenting symptom of Burkitt's Lymphoma. (19415057)
2009
16
High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma. (19759907)
2009
17
Primary cardiac onset of disseminated Burkitt's lymphoma. (18066547)
2008
18
Biology and treatment of Burkitt's lymphoma. (17534164)
2007
19
Burkitt's lymphoma of the duodenum in a patient with AIDS. (17653472)
2007
20
Dok1 expression and mutation in Burkitt's lymphoma cell lines. (16338067)
2007
21
Pediatric Burkitt's lymphoma: CT findings. (16933114)
2007
22
Burkitt's lymphoma following a pediatric liver transplantation: predictive negative value of serologic response to Epstein-Barr virus. (18246749)
2007
23
Mammographic, sonographic, and pathologic characteristics of Burkitt's lymphoma in a patient referred for diagnostic mammography. (16554574)
2006
24
Childhood craniofacial Burkitt's lymphoma presenting as maxillary swelling: report of a case and review of literature. (16734314)
2006
25
Functional role of phosphatidylinositol 3-kinase/Akt pathway on cell growth and lytic cycle of Epstein-Barr virus in the Burkitt's lymphoma cell line, P3HR-1. (16732486)
2006
26
Burkitt's lymphoma and previous AIDS-defining illnesses are not prognostic factors in AIDS-related non-Hodgkin's lymphoma. (16293885)
2005
27
Burkitt's lymphoma: an unusual cause of lip numbness. (16117360)
2005
28
Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. (16104877)
2005
29
Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma. (15611471)
2005
30
Endemic Burkitt's lymphoma: a polymicrobial disease? (15685227)
2005
31
Burkitt's lymphoma in Kenya: views from the 20th century. (15617419)
2004
32
Burkitt's lymphoma: the initial defining characteristics. (15622604)
2004
33
Mechanism for induction of hydroxyurea resistance and loss of latent EBV genome in hydroxyurea-treated Burkitt's lymphoma cell line Raji. (15221904)
2004
34
Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells. (12584570)
2003
35
The role of surgery in intraabdominal Burkitt's lymphoma in children. (13680491)
2003
36
Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new disease. (12646946)
2003
37
Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells. (12133989)
2002
38
Acute pancreatitis as the first manifestation of pancreatic Burkitt's lymphoma in a patient infected by the human immunodeficiency virus. (11417569)
2001
39
Burkitt's lymphoma shortly after an acute HIV infection, treated with highly active retroviral treatment. (11770227)
2001
40
Sporadic Burkitt's lymphoma presenting as solely orbital disease in a 78-year-old. (11318275)
2001
41
An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line. (10997876)
2000
42
Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent. (10946276)
2000
43
131I-Lym-1 in mice implanted with human Burkitt's lymphoma (Raji) tumors: loss of tumor specificity due to radiolysis. (11190487)
2000
44
CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells. (8695856)
1996
45
Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines. (7749063)
1995
46
AIDS-related Burkitt's lymphoma. Morphologic and immunophenotypic study of biopsy specimens. (7741100)
1995
47
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation. (8515068)
1993
48
Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma. (8397370)
1993
49
Tumor genesis syndrome. Hypophosphatemia accompanying Burkitt's lymphoma cell leukemia. (3724704)
1986
50
Infantile non-African Burkitt's lymphoma presenting as bilateral fulminant exophthalmos. (7153820)
1982

Genetic Variations for Burkitt's Lymphoma

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Expression for genes affiliated with Burkitt's Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Burkitt's Lymphoma

Search GEO for disease gene expression data for Burkitt's Lymphoma.

Pathways for genes affiliated with Burkitt's Lymphoma

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37NCBI BioSystems Database
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Pathways related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7IL13RA2, MYBL1, AICDA

Compounds for genes affiliated with Burkitt's Lymphoma

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1peg-104410.7CXCL13, CXCR5
2cytidine44 11 2412.4BCL6, MYC, AICDA

GO Terms for genes affiliated with Burkitt's Lymphoma

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16Gene Ontology
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Biological processes related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:03018310.7BCL6, POLM, AICDA
2lymph node developmentGO:04853510.7CXCL13, CXCR5
3germinal center formationGO:00246710.5BCL6, CXCL13
4somatic hypermutation of immunoglobulin genesGO:01644610.3POLM, AICDA

Products for genes affiliated with Burkitt's Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Burkitt's Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet