BL
MCID: BRK003
MIFTS: 71

Burkitt's Lymphoma (BL) malady

Cancer, Blood, Immune categories

Summaries for Burkitt's Lymphoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Lymphoma is a cancer of a part of the immune system called the lymph system. there are many types of lymphoma. one type is hodgkin disease. the rest are called non-hodgkin lymphomas. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors don't know why a person gets non-hodgkin lymphoma. you are at increased risk if you have a weakened immune system or have certain types of infections. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. targeted therapy uses substances that attack cancer cells without harming normal cells. biologic therapy boosts your body's own ability to fight cancer. if you don't have symptoms, you may not need treatment right away. this is called watchful waiting. nih: national cancer institute

MalaCards: Burkitt's Lymphoma, also known as burkitt lymphoma, is related to lymphoma, diffuse large cell and follicular lymphoma. An important gene associated with Burkitt's Lymphoma is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways is IL4-mediated signaling events. The drugs cyclophosphamide and asparaginase and the compounds peg-10 and cytidine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spinal cord, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

NIH Rare Diseases:43 Burkitt lymphoma (bl) is a rare, aggressive form of b-cell non-hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. it is more common in males than females. three forms exist: one endemic to africa that is linked to the epstein barr virus (ebv); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with hiv infection. bl can also develop in the ear, nose, throat and more rarely in other locations. signs and symptoms may differ depending on the form of bl and the organs or body systems affected. the exact cause of the condition is not known. treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. last updated: 6/26/2012

Description from OMIM:47 113970

Aliases & Classifications for Burkitt's Lymphoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 31LifeMap Discovery™, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 9diseasecard, 22GTR, 47OMIM, 49Orphanet, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
burkitt lymphoma:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

burkitt's lymphoma 8 43 31
burkitt lymphoma 8 9 43 22 47 45 49 61
lymphoma 8 10 45 34 61
small non-cleaved cell lymphoma, burkitt's type 8
burkitt's lymphoma of unspecified site 8
malignant lymphoma, burkitt's type 8
lymphoma, small noncleaved-cell 61
small non-cleaved cell lymphoma 49
burkitt's lymphoma - disorder 8
burkitt lymphoma/leukaemia 8
burkitt's lymphoma nos 8
burkitt's tumor nos 8
burkitts lymphoma 10
burkitt's tumour 8
burkitt's tumors 8
lymphatic cancer 61
lymphoid cancer 8
burkitt's tumor 8
bl 43


External Ids:

Disease Ontology8 DOID:8584, DOID:0060058
ICD9CM27 200.2
OMIM47 113970
MESH via Orphanet36 D002051, D008228
ICD10 via Orphanet26 C83.7
SNOMED-CT via Orphanet58 118617000, 22197008, 397400006 77381001, more
UMLS via Orphanet62 C0006413, C0079770
ICD1025 C83.7

Related Diseases for Burkitt's Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Burkitt's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1079)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell31.9MYC, BCL6
2follicular lymphoma31.7MYC, CXCR5, TCL1A, IGHM, BCL6, AICDA
3mantle cell lymphoma31.7SOX11
4gastric lymphoma31.6BCL6
5central nervous system lymphoma31.6BCL6
6central nervous system lymphoma, primary31.5CXCR5, BCL6, IGHM, CXCL13
7b-cell lymphomas31.3MYC, CXCL13, AICDA, BCL6, CXCR5, TCL1A
8peripheral t-cell lymphoma31.3TCL1A, BCL6, CXCL13
9intraocular lymphoma31.2CXCR5
10angioimmunoblastic t-cell lymphoma30.9CXCL13, BCL6
11non-hodgkin lymphoma30.5AICDA, CXCR5, SH2D1A, TCL1A, BCL6, MYC
12b-cell chronic lymphocytic leukemia30.5BCL6, IGHM, AICDA, TCL1A
13ataxia telangiectasia30.3AICDA, TCL1A
14hepatitis b30.3IGHM
15lymphoma, malt, somatic30.3IGHM, BCL6, CXCL13, CXCR5
16lymphoma aidsrelated29.9MYC, BCL6, TCL1A
17precursor b-cell acute lymphoblastic leukemia29.9CXCL13, MYC, CXCR5
18agammaglobulinemia29.7IGHM, SH2D1A
19common variable immune deficiency29.7SH2D1A, AICDA
20ipex syndrome29.5AICDA, BCL6, IGHM, SH2D1A, MPP1, CXCR5
21anaplastic large cell lymphoma11.1
22adult lymphoma11.0
23lymphoblastic lymphoma11.0
24bone lymphoma11.0
25diffuse large b-cell lymphoma11.0
26primary effusion lymphoma10.9
27leukemia/lymphoma, t-cell10.9
28t-cell leukemia10.9
29breast lymphoma10.9
30primary malignant lymphoma10.9
31thyroid lymphoma10.8
32splenic marginal zone lymphoma10.8
33gastrointestinal lymphoma10.8
34colon lymphoma10.8
35plasmablastic lymphoma10.8
36acute leukemia10.8
37pediatric lymphoma10.8
38cerebral lymphoma10.7
39adult t-cell leukemia10.7
40composite lymphoma10.7
41lymphoplasmacytic lymphoma10.7
42testicular lymphoma10.7
43primary bone lymphoma10.7
44mycosis fungoides10.7
45nodular lymphocyte predominant hodgkin lymphoma10.7
46primary cutaneous anaplastic large cell lymphoma10.7
47hepatitis c10.7
48lung lymphoma10.7
49n syndrome10.6
50kaposi's sarcoma10.6

Graphical network of the top 20 diseases related to Burkitt's Lymphoma:



Diseases related to burkitt's lymphoma

Clinical Features for Burkitt's Lymphoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

113970

Clinical synopsis from OMIM:

113970

Drugs & Therapeutics for Burkitt's Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Burkitt's Lymphoma

Drug clinical trials:

Search ClinicalTrials for Burkitt's Lymphoma

Search NIH Clinical Center for Burkitt's Lymphoma

Search CenterWatch for Burkitt's Lymphoma

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Burkitt's Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Burkitt's Lymphoma

Sources:
22GTR
See all sources

Genetic tests related to Burkitt's Lymphoma:

id Genetic test Affiliating Genes
1 Burkitt Lymphoma22

Anatomical Context for Burkitt's Lymphoma

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Burkitt's Lymphoma:

33
Bone marrow, Lymph node, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Lung, Ovary, T cells, B lymphoblasts, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Burkitt's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Burkitt's Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Burkitt's Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.5CXCL13, CXCR5, MYBL1, MYC, POLM, AICDA
2MP:000538711.5POLM, IL13RA2, CXCL13, CXCR5, MYBL1, MYC
3MP:000539711.2SH2B2, SH2D1A, IGHM, AICDA, POLM, MYC

Publications for Burkitt's Lymphoma

Sources:
51PubMed
See all sources

Articles related to Burkitt's Lymphoma:

(show top 50)    (show all 320)
idTitleAuthorsYear
1
A new diagnostic algorithm for Burkitt and diffuse large B-cell lymphomas based on the expression of CSE1L and STAT3 and on MYC rearrangement predicts outcome. (22967991)
2013
2
Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement. (23012230)
2013
3
Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: Experience of a single institution in Argentina. (24027016)
2013
4
Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene. (23276184)
2013
5
Clinical course and prognostic factors of children with Burkitt's lymphoma in a developing country: the experience of a single centre in Brazil. (23125545)
2012
6
Specific tumor-stroma interactions of EBV-positive Burkitt's lymphoma cells in the chick chorioallantoic membrane. (22404859)
2012
7
A patient with primary Burkitt's lymphoma of the postnasal space: case report. (22695293)
2012
8
TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases. (22845047)
2012
9
Spontaneous conception and live birth after gonadotoxic chemotherapy for an aggressive bilateral ovarian Burkitt's lymphoma. (21621900)
2011
10
The RB (pRb2/p16) and p53 (p14/p53/p21) tumor-suppressor pathways in endemic Burkitt lymphoma. (21127431)
2011
11
Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas. (20348878)
2010
12
Clinical and epidemiological characterisation of Burkitt's lymphoma: an eight-year case study at Komfo Anokye Teaching Hospital, Ghana. (20373676)
2010
13
Activation of the lytic program of the Epstein-Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent. (19254802)
2009
14
Burkitt's lymphoma: the Rosetta Stone deciphering Epstein-Barr virus biology. (19619657)
2009
15
Clinicopathologic features and Epstein-Barr virus infection status of Burkitt's lymphoma in Guangzhou district. (19664325)
2009
16
Immunohistochemical study using T-cell lymphoma antibody 1 and CD44 in diagnosis of Burkitt's lymphoma]. (20079013)
2009
17
Stage 2 hypertension in a child with a rapidly enlarging kidney: question. Burkitt's lymphoma. (18038240)
2008
18
Detection of Epstein-Barr virus in children and adolescents with Burkitt's lymphoma by in situ hybridization using tissue microarrays. (18616879)
2008
19
Stage 2 hypertension in a child with a rapidly enlarging kidney: answer. Burkitt's lymphoma. (18038241)
2008
20
The presence or absence of latent Epstein-Barr virus does not alter the sensitivity of Burkitt's lymphoma cell lines to proteasome inhibitors. (18594134)
2008
21
The peptide nucleic acid targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma lacks immunogenicity: follow-up characterization of PNAEmu-NLS. (17461771)
2007
22
Ocular manifestations of Burkitt's lymphoma: experience in Ile-Ife south western Nigeria. (17595992)
2007
23
Down-regulation of expression of survivin and induction of apoptosis in the human Burkitt lymphomas cells by ligation of CD40-CD40L]. (17199985)
2006
24
Sporadic Burkitt's lymphoma of the jaws: the essentials of prompt life-saving referral and management. (15763034)
2005
25
Socioeconomic constraints to effective management of Burkitt's lymphoma in south-eastern Nigeria. (15655018)
2005
26
Hydrogen peroxide in the Burkitt's lymphoma cell line Raji provides protection against arsenic trioxide-induced apoptosis via the phosphoinositide-3 kinase signalling pathway. (15142122)
2004
27
Aspects of epidemiological and clinical features of patients with central nervous system Burkitt's lymphoma in Kenya. (15622608)
2004
28
Unusual sites of metastatic malignancy: case 2. Burkitt's lymphoma involving the gallbladder. (15611517)
2004
29
Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways. (12464623)
2003
30
Temporal ordering of caspase activation and substrate cleavage during antigen receptor-triggered apoptosis in Ramos-Burkitt lymphoma B cells. (12851674)
2003
31
NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor. (12594826)
2003
32
Burkitt lymphoma following splenic marginal zone lymphoma. evidence for two independent B-cell clones. (12581905)
2003
33
Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia. (11920506)
2002
34
Sustained complete remission following a combination of very low intensity chemotherapy with rituximab in an elderly patient with Burkitt's lymphoma. (11801488)
2002
35
From Burkitt's lymphoma to chronic active Epstein-Barr virus (EBV) infection: an expanding spectrum of EBV-associated diseases. (11594706)
2001
36
Burkitt's lymphoma shortly after an acute HIV infection, treated with highly active retroviral treatment. (11770227)
2001
37
The Epstein-Barr virus latent membrane protein 1 induces interleukin-10 in Burkitt's lymphoma cells but not in Hodgkin's cells involving the p38/SAPK2 pathway. (11162833)
2001
38
Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation. (10969772)
2000
39
131I-Lym-1 in mice implanted with human Burkitt's lymphoma (Raji) tumors: loss of tumor specificity due to radiolysis. (11190487)
2000
40
Burkitt's lymphoma presenting as ileocaecal intussusception in systemic lupus erythematosus. (11206354)
1999
41
Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL60 Burkitt lymphoma cells. (9485209)
1998
42
Application of interphase fluorescence in situ Hybridization for the detection of the Burkitt translocation t(8;14)(q24;q32) in B-cell lymphomas. (9446660)
1998
43
Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand. (9763568)
1998
44
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
45
Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma. (8670211)
1996
46
Cationic lipids reduce time and dose of c-myc antisense oligodeoxynucleotides required to specifically inhibit Burkitt's lymphoma cell growth. (8946941)
1996
47
Bell's palsy as a sign of Burkitt's lymphoma in children. (7655035)
1995
48
AIDS-related Burkitt's lymphoma. Morphologic and immunophenotypic study of biopsy specimens. (7741100)
1995
49
Small non-cleaved-cell lymphoma (undifferentiated lymphoma, Burkitt's type) in American adults: results with treatment designed for acute lymphoblastic leukemia. (2003515)
1991
50
Nodular lymphoid hyperplasia of the small intestine with Burkitt's lymphoma and dysgammaglobulinemia. (7308712)
1981

Genetic Variations for Burkitt's Lymphoma

Expression for genes affiliated with Burkitt's Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Burkitt's Lymphoma

Search GEO for disease gene expression data for Burkitt's Lymphoma.

Pathways for genes affiliated with Burkitt's Lymphoma

Sources:
38NCBI BioSystems Database
See all sources

Pathways related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7IL13RA2, MYBL1, AICDA

Compounds for genes affiliated with Burkitt's Lymphoma

Sources:
45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1peg-104510.7CXCL13, CXCR5
2cytidine45 11 2412.4BCL6, MYC, AICDA

GO Terms for genes affiliated with Burkitt's Lymphoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:03018310.7BCL6, POLM, AICDA
2lymph node developmentGO:04853510.7CXCL13, CXCR5
3germinal center formationGO:00246710.5BCL6, CXCL13
4somatic hypermutation of immunoglobulin genesGO:01644610.3POLM, AICDA

Products for genes affiliated with Burkitt's Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Burkitt's Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet