BL
MCID: BRK003
MIFTS: 78

Burkitt's Lymphoma (BL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Burkitt's Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 46OMIM, 32MalaCards
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MedlinePlus:33 Lymphoma is a cancer of a part of the immune system called the lymph system. there are many types of lymphoma. one type is hodgkin disease. the rest are called non-hodgkin lymphomas. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors don't know why a person gets non-hodgkin lymphoma. you are at increased risk if you have a weakened immune system or have certain types of infections. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. targeted therapy uses substances that attack cancer cells without harming normal cells. biologic therapy boosts your body's own ability to fight cancer. if you don't have symptoms, you may not need treatment right away. this is called watchful waiting. nih: national cancer institute

MalaCards: Burkitt's Lymphoma, also known as burkitt lymphoma, is related to hodgkin's lymphoma and leukemia. An important gene associated with Burkitt's Lymphoma is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways is IL4-mediated signaling events. The drugs cyclophosphamide and asparaginase and the compounds peg-10 and cytidine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are cellular and immune system.

Disease Ontology:8 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

NIH Rare Diseases:42 Burkitt lymphoma (bl) is a rare, aggressive form of b-cell non-hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. it is more common in males than females. three forms exist: one endemic to africa that is linked to the epstein barr virus (ebv); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with hiv infection. bl can also develop in the ear, nose, throat and more rarely in other locations. signs and symptoms may differ depending on the form of bl and the organs or body systems affected. the exact cause of the condition is not known. treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. last updated: 6/26/2012

Description from OMIM:46 113970

Aliases & Classifications for Burkitt's Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 30LifeMap Discovery™, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 22GTR, 46OMIM, 48Orphanet, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
burkitt lymphoma:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

burkitt's lymphoma 8 42 30
burkitt lymphoma 8 9 42 22 46 44 48 60
lymphoma 8 10 44 33 60
small non-cleaved cell lymphoma, burkitt's type 8
burkitt's lymphoma of unspecified site 8
malignant lymphoma, burkitt's type 8
lymphoma, small noncleaved-cell 60
small non-cleaved cell lymphoma 48
burkitt's lymphoma - disorder 8
burkitt lymphoma/leukaemia 8
burkitt's lymphoma nos 8
burkitt's tumor nos 8
burkitts lymphoma 10
lymphoid neoplasm 44
burkitt's tumour 8
burkitt's tumors 8
lymphatic cancer 60
lymphoid cancer 8
burkitt's tumor 8
bl 42


External Ids:

Disease Ontology8 DOID:8584, DOID:0060058
ICD9CM27 200.2
OMIM46 113970
MESH via Orphanet35 D002051, D008228
ICD10 via Orphanet26 C83.7
SNOMED-CT via Orphanet57 118617000, 22197008, 397400006 77381001, more
UMLS via Orphanet61 C0006413, C0079770
ICD1025 C83.7

Related Diseases for Burkitt's Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Burkitt's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1108)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma31.9AICDA, BCL6, SH2D1A, TCL1A, IGHM, MPP1
2leukemia31.7CXCR5, TCL1A, BCL6, AICDA, MYC, SH2D1A
3mantle cell lymphoma31.7SOX11
4non-hodgkin lymphoma31.7AICDA, CXCR5, SH2D1A, TCL1A, BCL6, MYC
5gastric lymphoma31.6BCL6
6central nervous system lymphoma31.5BCL6
7intraocular lymphoma31.2CXCR5
8chronic lymphocytic leukemia31.1BCL6, TCL1A, IGHM, AICDA, CXCR5
9myeloma30.9TCL1A, BCL6, CXCR5, MYC, IGHM
10hepatitis b30.8IGHM
11rheumatoid arthritis30.5IGHM, CXCR5
12plasmacytoma30.4BCL6, MYC, AICDA, CXCR5
13central nervous system lymphoma, primary30.3CXCR5, BCL6, IGHM, CXCL13
14ataxia telangiectasia30.3AICDA, TCL1A
15angioimmunoblastic t-cell lymphoma30.3CXCL13, BCL6
16follicular lymphoma30.3MYC, CXCR5, TCL1A, IGHM, BCL6, AICDA
17prolymphocytic leukemia30.2TCL1A, MYC
18b-cell lymphomas30.2MYC, CXCL13, AICDA, BCL6, CXCR5, TCL1A
19peripheral t-cell lymphoma30.1TCL1A, BCL6, CXCL13
20malt lymphoma30.1IGHM, BCL6, CXCL13, CXCR5
21lymphoma, diffuse large cell29.9MYC, BCL6
22b-cell chronic lymphocytic leukemia29.9BCL6, IGHM, AICDA, TCL1A
23lymphoma aidsrelated29.9MYC, BCL6, TCL1A
24precursor b-cell acute lymphoblastic leukemia29.6CXCL13, MYC, CXCR5
25agammaglobulinemia29.6IGHM, SH2D1A
26common variable immune deficiency29.6SH2D1A, AICDA
27ipex syndrome29.4AICDA, BCL6, IGHM, SH2D1A, MPP1, CXCR5
28diffuse large b-cell lymphoma11.2
29anaplastic large cell lymphoma11.1
30cutaneous t cell lymphoma11.1
31adult lymphoma11.0
32t-cell leukemia11.0
33marginal zone b-cell lymphoma11.0
34bone lymphoma10.9
35adult t-cell leukemia10.9
36breast lymphoma10.9
37thyroid lymphoma10.8
38splenic marginal zone lymphoma10.8
39thyroiditis10.8
40gastrointestinal lymphoma10.8
41mediastinitis10.8
42acute leukemia10.8
43pediatric lymphoma10.8
44lymphoblastic leukemia10.7
45cerebral lymphoma10.7
46hepatitis10.7
47composite lymphoma10.7
48lymphoplasmacytic lymphoma10.7
49panniculitis10.7
50sarcoma10.7

Graphical network of the top 20 diseases related to Burkitt's Lymphoma:



Diseases related to burkitt's lymphoma

Clinical Features for Burkitt's Lymphoma

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Sources:
46OMIM
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Clinical features from OMIM:

113970

Clinical synopsis from OMIM:

113970

Drugs & Therapeutics for Burkitt's Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Burkitt's Lymphoma

Drug clinical trials:

Search ClinicalTrials for Burkitt's Lymphoma

Search NIH Clinical Center for Burkitt's Lymphoma

Search CenterWatch for Burkitt's Lymphoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Burkitt's Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Burkitt's Lymphoma

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Sources:
22GTR
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Genetic tests related to Burkitt's Lymphoma:

id Genetic test Affiliating Genes
1 Burkitt Lymphoma22

Anatomical Context for Burkitt's Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Burkitt's Lymphoma:

32
B cells, T cells, Lymph node, Testes, Bone, Breast, Bone marrow, Ovary, Colon, Kidney, Small intestine, Thyroid, Tongue, Liver, Heart, Brain, Endothelial, Pancreas, Appendix, B lymphoblasts

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Burkitt's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Burkitt's Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Burkitt's Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.5CXCL13, CXCR5, MYBL1, MYC, POLM, AICDA
2MP:000538711.5POLM, IL13RA2, CXCL13, CXCR5, MYBL1, MYC
3MP:000539711.2SH2B2, SH2D1A, IGHM, AICDA, POLM, MYC

Publications for Burkitt's Lymphoma

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50PubMed
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Articles related to Burkitt's Lymphoma:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature. (23414881)
2013
2
High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells. (23399385)
2013
3
Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: Experience of a single institution in Argentina. (24027016)
2013
4
Downregulation of the polyamine regulator spermidine/spermine N(1)-acetyltransferase by Epstein-Barr virus in a Burkitt's lymphoma cell line. (23891576)
2013
5
Rituximab Synergizes with Hydroxyurea or Vincristine in the Killing of Ramos Burkitt's Lymphoma B Cell Line. (24256491)
2013
6
Genetic sequencing studies in Burkitt's lymphoma: what can we learn about tumorigenesis? (23782073)
2013
7
Clinical course and prognostic factors of children with Burkitt's lymphoma in a developing country: the experience of a single centre in Brazil. (23125545)
2012
8
Specific tumor-stroma interactions of EBV-positive Burkitt's lymphoma cells in the chick chorioallantoic membrane. (22404859)
2012
9
Burkitt's lymphoma: a rare cause of isolated trigeminal neuralgia in a child. (22427256)
2012
10
Primary Burkitt's lymphoma of the colon--an uncommon cause of acute constipation and abdominal pain. (22417079)
2012
11
Pediatric, elderly, and emerging adult-onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding Africa. (22488262)
2012
12
Orbital Burkitt's Lymphoma: An Aggressive Presentation. (22606490)
2012
13
DLC-1 as a modulator of proliferation, apoptosis and migration in Burkitt's lymphoma cells. (20882354)
2011
14
Burkitt's lymphoma in early pregnancy. (20048180)
2010
15
Severe lactic acidosis, hypertriglyceridemia, and extensive axial skeleton involvement in a case of disseminated Burkitt's lymphoma. (20213117)
2010
16
Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis. (20823134)
2010
17
Endemic Burkitt's lymphoma as a polymicrobial disease: new insights on the interaction between Plasmodium falciparum and Epstein-Barr virus. (19897039)
2009
18
Burkitt's lymphoma: the Rosetta Stone deciphering Epstein-Barr virus biology. (19619657)
2009
19
Immunohistochemical study using T-cell lymphoma antibody 1 and CD44 in diagnosis of Burkitt's lymphoma]. (20079013)
2009
20
PNAEmu can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease. (19363465)
2009
21
Complete remission of gastric Burkitt's lymphoma after eradication of Helicobacter pylori. (19960575)
2009
22
Second Epstein-Barr virus-associated Burkitt's lymphoma of the CNS in a child with progressive renal failure. (18565896)
2008
23
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells. (17214905)
2007
24
Burkitt's lymphoma with loss of the long arm of chromosome 1. (17141537)
2007
25
The peptide nucleic acid targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma lacks immunogenicity: follow-up characterization of PNAEmu-NLS. (17461771)
2007
26
Retinoblastoma-related geneRb2/p130 are rarely mutated in Burkitt's lymphoma from Brazil. (16955460)
2007
27
A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma. (17410366)
2007
28
IRF4 negatively regulates proliferation of germinal center B cell-derived Burkitt's lymphoma cell lines and induces differentiation toward plasma cells. (17651861)
2007
29
Burkitt's lymphoma presenting as oculomotor palsy in an hiv-positive patient. (16496269)
2006
30
c-Myc over-expression in Ramos Burkitt's lymphoma cell line predisposes to iron homeostasis disruption in vitro. (16466700)
2006
31
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. (16760442)
2006
32
Is Burkitt's lymphoma sexy enough? (17189037)
2006
33
Melena: a rare presentation of childhood Burkitt's lymphoma. (16076817)
2005
34
Long distance polymerase chain reaction of ascites lymphoma cells aids diagnosis establishment of abdominal Burkitt's lymphoma and Burkitt-like lymphoma. (15621785)
2005
35
Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus. (15287031)
2004
36
Burkitt's lymphoma of the stomach: a case report with molecular cytogenetic analysis. (15291367)
2004
37
Challenging and unusual cases: Case 2. Concurrent gastrointestinal stromal tumor and Burkitt's lymphoma. (12663737)
2003
38
High expression of apoptosis-regulating proteins in Burkitt's lymphomas. (11869962)
2002
39
Analysis of SH2D1A mutations in patients with severe Epstein-Barr virus infections, Burkitt's lymphoma, and Hodgkin's lymphoma. (12224001)
2002
40
VH gene analysis in sporadic Burkitt's lymphoma: somatic mutation and intraclonal diversity with special reference to the tumor cells involving germinal center. (11908722)
2002
41
Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line. (11526098)
2001
42
Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells. (11559830)
2001
43
Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma. (11587216)
2001
44
Retinoic acid induces persistent, RARalpha-mediated anti-proliferative responses in Epstein-Barr virus-immortalized b lymphoblasts carrying an activated C-MYC oncogene but not in Burkitt's lymphoma cell lines. (10760826)
2000
45
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. (10416592)
1999
46
Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma. (9402172)
1997
47
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
48
Generation of a variant t(2;8) translocation of Burkitt's lymphoma by site-specific recombination via the kappa light-chain joining signals. (3110600)
1987
49
Subcutaneous zygomycosis caused by Basidiobolus haptosporus: presentation of a case mimicking Burkitt's lymphoma. (7200333)
1982
50
Oral African histoplasmosis resembling Burkitt's lymphoma. (278937)
1978

Genetic Variations for Burkitt's Lymphoma

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Expression for genes affiliated with Burkitt's Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Burkitt's Lymphoma

Search GEO for disease gene expression data for Burkitt's Lymphoma.

Pathways for genes affiliated with Burkitt's Lymphoma

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37NCBI BioSystems Database
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Pathways related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7IL13RA2, MYBL1, AICDA

Compounds for genes affiliated with Burkitt's Lymphoma

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1peg-104410.7CXCL13, CXCR5
2cytidine44 11 2412.4BCL6, MYC, AICDA

GO Terms for genes affiliated with Burkitt's Lymphoma

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16Gene Ontology
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Biological processes related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:03018310.7BCL6, POLM, AICDA
2lymph node developmentGO:04853510.7CXCL13, CXCR5
3germinal center formationGO:00246710.5BCL6, CXCL13
4somatic hypermutation of immunoglobulin genesGO:01644610.3POLM, AICDA

Products for genes affiliated with Burkitt's Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Burkitt's Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet