BL
MCID: BRK003
MIFTS: 77

Burkitt's Lymphoma (BL) malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories
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Summaries for Burkitt's Lymphoma

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8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 47OMIM, 33MalaCards
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MedlinePlus:34 Lymphoma is a cancer of a part of the immune system called the lymph system. there are many types of lymphoma. one type is hodgkin disease. the rest are called non-hodgkin lymphomas. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors don't know why a person gets non-hodgkin lymphoma. you are at increased risk if you have a weakened immune system or have certain types of infections. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. targeted therapy uses substances that attack cancer cells without harming normal cells. biologic therapy boosts your body's own ability to fight cancer. if you don't have symptoms, you may not need treatment right away. this is called watchful waiting. nih: national cancer institute

MalaCards: Burkitt's Lymphoma, also known as burkitt lymphoma, is related to b-cell lymphomas and hodgkin's lymphoma. An important gene associated with Burkitt's Lymphoma is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways are FoxO family signaling and Lymphocyte Signaling. The drugs cyclophosphamide and asparaginase and the compounds suberoylanilide hydroxamic acid and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are no phenotypic analysis and normal.

Disease Ontology:8 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

NIH Rare Diseases:43 Burkitt lymphoma (bl) is a rare, aggressive form of b-cell non-hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. it is more common in males than females. three forms exist: one endemic to africa that is linked to the epstein barr virus (ebv); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with hiv infection. bl can also develop in the ear, nose, throat and more rarely in other locations. signs and symptoms may differ depending on the form of bl and the organs or body systems affected. the exact cause of the condition is not known. treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. last updated: 6/26/2012

Description from OMIM:47 113970

Aliases & Classifications for Burkitt's Lymphoma

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8Disease Ontology, 43NIH Rare Diseases, 31LifeMap Discovery™, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 9diseasecard, 22GTR, 47OMIM, 49Orphanet, 40NCIt, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
burkitt lymphoma:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

burkitt's lymphoma 8 43 31
burkitt lymphoma 8 9 43 22 47 45 49 62
lymphoma 8 10 45 34 62
small non-cleaved cell lymphoma, burkitt's type 8
burkitt's lymphoma of unspecified site 8
malignant lymphoma, burkitt's type 8
lymphoma, small noncleaved-cell 62
small non-cleaved cell lymphoma 49
burkitt's lymphoma - disorder 8
burkitt lymphoma/leukaemia 8
burkitt's lymphoma nos 8
burkitt's tumor nos 8
burkitts lymphoma 10
lymphoid neoplasm 45
burkitt's tumour 8
burkitt's tumors 8
lymphatic cancer 62
lymphoid cancer 8
burkitt's tumor 8
bl 43


External Ids:

Disease Ontology8 DOID:8584, DOID:0060058
ICD9CM27 200.2
OMIM47 113970
MESH via Orphanet36 D002051, D008228
ICD10 via Orphanet26 C83.7
SNOMED-CT via Orphanet59 118617000, 22197008, 397400006 77381001, more
UMLS via Orphanet63 C0006413, C0079770
ICD1025 C83.7

Related Diseases for Burkitt's Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Burkitt's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1222)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas32.1AICDA, IGHM, MYC, TCL1A, CXCR5, BCL6
2hodgkin's lymphoma31.8AICDA, IGHM, SH2D1A, MPP1, TCL1A, IL13RA2
3central nervous system lymphoma31.7BCL6
4malt lymphoma31.6BCL6, CXCR5, IGHM
5follicular lymphoma31.6AICDA, IGHM, MYC, TCL1A, CXCR5, BCL6
6non-hodgkin lymphoma31.6AICDA, SH2D1A, MYC, TCL1A, CXCR5, BCL6
7peripheral t-cell lymphoma31.6BCL6, TCL1A
8leukemia31.6AICDA, SH2D1A, MYC, TCL1A, CXCR5, BCL6
9intraocular lymphoma31.4CXCR5
10chronic lymphocytic leukemia31.1BCL6, CXCR5, TCL1A, IGHM, AICDA
11myeloma30.9BCL2L11, BCL6, CXCR5, TCL1A, MYC, IGHM
12b-cell chronic lymphocytic leukemia30.7BCL6, TCL1A, IGHM, AICDA
13central nervous system lymphoma, primary30.5IGHM, CXCR5, BCL6
14plasmacytoma30.4AICDA, MYC, CXCR5, BCL6
15prolymphocytic leukemia30.4MYC, TCL1A
16lymphoma, diffuse large cell30.3MYC, BCL6
17lymphoma aidsrelated30.0MYC, TCL1A, BCL6
18leukemia, acute lymphoblastic 329.8CXCR5, MYC
19agammaglobulinemia29.8SH2D1A, IGHM
20common variable immune deficiency29.7SH2D1A, AICDA
21ipex syndrome29.4AICDA, IGHM, SH2D1A, MPP1, CXCR5, BCL6
22diffuse large b-cell lymphoma11.3
23mantle cell lymphoma11.1
24anaplastic large cell lymphoma11.1
25cutaneous t cell lymphoma11.1
26lymphoblastic lymphoma11.0
27marginal zone b-cell lymphoma11.0
28gastric lymphoma11.0
29t-cell leukemia11.0
30primary effusion lymphoma10.9
31adult t-cell leukemia10.9
32angioimmunoblastic t-cell lymphoma10.9
33thyroiditis10.8
34primary malignant lymphoma10.8
35mediastinitis10.8
36plasmablastic lymphoma10.8
37splenic marginal zone lymphoma10.8
38intravascular large b-cell lymphoma10.8
39thyroid lymphoma10.8
40hepatitis10.8
41panniculitis10.7
42sarcoma10.7
43cerebritis10.7
44lymphoplasmacytic lymphoma10.7
45subcutaneous panniculitis-like t-cell lymphoma10.7
46gastrointestinal lymphoma10.7
47breast lymphoma10.7
48cerebral lymphoma10.7
49mycosis fungoides10.7
50lymphoblastic leukemia10.7

Graphical network of the top 20 diseases related to Burkitt's Lymphoma:



Diseases related to burkitt's lymphoma

Symptoms for Burkitt's Lymphoma

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Sources:
47OMIM
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Symptoms by clinical synopsis from OMIM:

113970

Clinical features from OMIM:

113970

Drugs & Therapeutics for Burkitt's Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Burkitt's Lymphoma

Search NIH Clinical Center for Burkitt's Lymphoma

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Burkitt's Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Burkitt's Lymphoma

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Sources:
22GTR
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Genetic tests related to Burkitt's Lymphoma:

id Genetic test Affiliating Genes
1 Burkitt Lymphoma22

Anatomical Context for Burkitt's Lymphoma

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Burkitt's Lymphoma:

33
B cells, T cells, Lymph node, Testes, Bone, Breast, Bone marrow, Ovary, Colon, Kidney, Small intestine, Thyroid, Liver, Tongue, Heart, Endothelial, Brain, Pancreas, Appendix, B lymphoblasts

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Burkitt's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Burkitt's Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Burkitt's Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7BCL2L11, BCL6, MYC, IGHM, AICDA
2MP:00028737.8AICDA, IGHM, MYC, MYBL1, BCL6, BCL2L11
3MP:00053767.3IGHM, SH2D1A, MYC, MYBL1, IL13RA2, BCL6
4MP:00053847.3AICDA, IGHM, MPP1, MYC, MYBL1, CXCR5
5MP:00053897.1MPP1, POLM, MYC, MYBL1, TCL1A, BCL6
6MP:00053976.3BCL2L11, AICDA, IGHM, SH2D1A, MPP1, POLM
7MP:00053876.2MPP1, SH2D1A, IGHM, AICDA, POLM, MYC

Publications for Burkitt's Lymphoma

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Sources:
52PubMed
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Articles related to Burkitt's Lymphoma:

(show top 50)    (show all 599)
idTitleAuthorsYear
1
Pediatric Burkitt's Lymphoma and Diffuse B-Cell Lymphoma: Are Surveillance Scans Required? (24087880)
2013
2
Burkitt's lymphoma treatment in a rural hospital in Sierra Leone. (24021903)
2013
3
Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature. (23762688)
2013
4
Primary endobronchial Burkitt's lymphoma in a child: a case report. (23548894)
2013
5
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis. (24013231)
2013
6
PEG10 promotes the migration of human Burkitt's lymphoma cells by up-regulating the expression of matrix metalloproteinase-2 and -9. (22673314)
2012
7
Epidemiology of Burkitt's lymphoma in Northwest Province, Cameroon, 2003-2010. (22595214)
2012
8
Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics. (22241218)
2012
9
Comparative proteomic analysis implicates COMMD proteins as Epstein-Barr virus targets in the BL41 Burkitt's lymphoma cell line. (21615174)
2011
10
A case report of fatal tumor lysis syndrome after chemotherapy in a pregnant patient with Burkitt's lymphoma. (21481095)
2011
11
Burkitt's lymphoma in pregnancy with bilateral breast involvement: case report with review of the literature. (20838063)
2010
12
Burkitt's lymphoma in early pregnancy. (20048180)
2010
13
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response. (20723265)
2010
14
Novel lymphoid neoplasms--the borderland between diffuse large B-cell lymphoma and Burkitt's lymphoma. (19570750)
2009
15
Tumor lysis and acute renal failure in Burkitt's lymphoma: A review on pathophysiology and management. (20436725)
2009
16
Identification of genes deregulated during serum-free medium adaptation of a Burkitt's lymphoma cell line. (18211290)
2008
17
The curious case of the tumour virus: 50 years of Burkitt's lymphoma. (19008891)
2008
18
Primary cardiac onset of disseminated Burkitt's lymphoma. (18066547)
2008
19
Second Epstein-Barr virus-associated Burkitt's lymphoma of the CNS in a child with progressive renal failure. (18565896)
2008
20
Burkitt's lymphoma-- what is new? (18814529)
2008
21
Pilot study of sodium phenylbutyrate as adjuvant in cyclophosphamide-resistant endemic Burkitt's lymphoma. (17915270)
2007
22
Burkitt's lymphoma: conversion from lymphoma negative to lymphoma positive status over 2 months in a patient with acquired immunodeficiency syndrome (AIDS). (18091062)
2007
23
Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer. (17287852)
2007
24
Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. (17703817)
2007
25
Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model. (16288493)
2006
26
Burkitt'S lymphoma mimicking a primary gynecologic tumor. (17197360)
2006
27
Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (16614233)
2006
28
Cytomorphology and immunophenotyping of Burkitt's lymphoma presenting as a breast mass. (16509847)
2006
29
Sporadic Burkitt's lymphoma of the jaws: the essentials of prompt life-saving referral and management. (15763034)
2005
30
Burkitt's lymphoma: an unusual cause of obstructive jaundice. (16234085)
2005
31
Burkitt's lymphoma: an unusual cause of lip numbness. (15819153)
2005
32
Variable problems in lymphomas: CASE 1. Burkitt's lymphoma presenting with central airway obstruction. (16258109)
2005
33
Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus. (15287031)
2004
34
Combined polymerase chain reaction methods to detect c-myc/IgH rearrangement in childhood Burkitt's lymphoma for minimal residual disease analysis. (15257933)
2004
35
Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells. (12584570)
2003
36
Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways. (12464623)
2003
37
Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. (12733111)
2003
38
Distinct patterns of mitogen-activated protein kinase phosphorylation and Epstein-Barr virus gene expression in Burkitt's lymphoma cell lines versus B lymphoblastoid cell lines. (12206304)
2002
39
A Myc-associated zinc finger protein-related factor binding site is required for the deregulation of c-myc expression by the immunoglobulin heavy chain gene enhancers in Burkitt's lymphoma. (11777933)
2002
40
Hodgkin's disease after treatment for Burkitt's lymphoma: case report. (12002116)
2001
41
Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line. (11526098)
2001
42
An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line. (10997876)
2000
43
Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation. (10969772)
2000
44
Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent. (10946276)
2000
45
The AT-rich region between -54 to -66 is important for the promoter activity of interleukin-10 in Epstein-Barr virus positive Burkitt's lymphoma cells. (11196656)
1999
46
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
47
CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells. (8695856)
1996
48
Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma. (8670211)
1996
49
Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines. (7749063)
1995
50
Generation of a variant t(2;8) translocation of Burkitt's lymphoma by site-specific recombination via the kappa light-chain joining signals. (3110600)
1987

Variations for Burkitt's Lymphoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Burkitt's Lymphoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1MYCNM_002467.4(MYC): c.214C> T (p.Pro72Ser)single nucleotide variantPathogenicrs28933407GRCh37Chr 8, 128750677: 128750677
2MYCNM_002467.4(MYC): c.302A> C (p.Asn101Thr)single nucleotide variantPathogenicrs121918683GRCh37Chr 8, 128750765: 128750765
3MYCNM_002467.4(MYC): c.162G> C (p.Glu54Asp)single nucleotide variantPathogenicrs121918684GRCh37Chr 8, 128750625: 128750625
4MYCNM_002467.4(MYC): c.220C> G (p.Pro74Ala)single nucleotide variantPathogenicrs121918685GRCh37Chr 8, 128750683: 128750683

Expression for genes affiliated with Burkitt's Lymphoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Burkitt's Lymphoma

Search GEO for disease gene expression data for Burkitt's Lymphoma.

Pathways for genes affiliated with Burkitt's Lymphoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology
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Pathways related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4BCL2L11, BCL6
29.2BCL6, SH2D1A, AICDA
3
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.2BCL2L11, BCL6, MYC
49.2IGHM, BCL6, BCL2L11
58.4BCL6, IL13RA2, MYBL1, AICDA

Compounds for genes affiliated with Burkitt's Lymphoma

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1suberoylanilide hydroxamic acid4510.0BCL2L11, MYC
2depsipeptide459.7BCL2L11, MYC
3cytidine45 24 1111.3BCL6, MYC, AICDA
4imatinib45 51 1111.2MYC, BCL6, BCL2L11
5cycloheximide458.8BCL2L11, BCL6, MYC, AICDA
6estrogen458.4BCL2L11, BCL6, MYBL1, MYC, AICDA

GO Terms for genes affiliated with Burkitt's Lymphoma

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16Gene Ontology
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Biological processes related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328010.0BCL2L11, MYC
2somatic hypermutation of immunoglobulin genesGO:0164469.4POLM, AICDA
3B cell differentiationGO:0301838.8BCL6, POLM, AICDA

Products for genes affiliated with Burkitt's Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Burkitt's Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet