BL
MCID: BRK003
MIFTS: 77

Burkitt's Lymphoma (BL) malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories
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Summaries for Burkitt's Lymphoma

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MedlinePlus:33 Lymphoma is a cancer of a part of the immune system called the lymph system. there are many types of lymphoma. one type is hodgkin disease. the rest are called non-hodgkin lymphomas. non-hodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. the cell divides again and again, making more and more abnormal cells. these abnormal cells can spread to almost any other part of the body. most of the time, doctors don't know why a person gets non-hodgkin lymphoma. you are at increased risk if you have a weakened immune system or have certain types of infections. non-hodgkin lymphoma can cause many symptoms, such as swollen, painless lymph nodes in the neck, armpits or groin unexplained weight loss fever soaking night sweats coughing, trouble breathing or chest pain weakness and tiredness that don't go away pain, swelling or a feeling of fullness in the abdomen your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. targeted therapy uses substances that attack cancer cells without harming normal cells. biologic therapy boosts your body's own ability to fight cancer. if you don't have symptoms, you may not need treatment right away. this is called watchful waiting. nih: national cancer institute

MalaCards based summary: Burkitt's Lymphoma, also known as burkitt lymphoma, is related to central nervous system lymphoma and intraocular lymphoma, and has symptoms including An important gene associated with Burkitt's Lymphoma is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways are FoxO family signaling and Lymphocyte Signaling. The drugs thiotepa and cyclophosphamide and the compounds suberoylanilide hydroxamic acid and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are no phenotypic analysis and normal.

Disease Ontology:8 A mature b-cell neoplasm of b-cells found in the germinal center.

NIH Rare Diseases:42 Burkitt lymphoma (bl) is a rare, aggressive form of b-cell non-hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. it is more common in males than females. three forms exist: one endemic to africa that is linked to the epstein barr virus (ebv); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with hiv infection. bl can also develop in the ear, nose, throat and more rarely in other locations. signs and symptoms may differ depending on the form of bl and the organs or body systems affected. the exact cause of the condition is not known. treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. last updated: 6/26/2012

Description from OMIM:46 113970

Aliases & Classifications for Burkitt's Lymphoma

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 9diseasecard, 22GTR, 46OMIM, 44Novoseek, 62UMLS, 10DISEASES, 33MedlinePlus, 57SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Burkitt's Lymphoma, Aliases & Descriptions:

Name: Burkitt's Lymphoma 30 8 42
Burkitt Lymphoma 8 9 42 22 46 44 48 62
Lymphoma 8 10 44 33 62
Burkitt Lymphoma/leukaemia 8 62
Lymphoid Neoplasm 44 62
Small Non-Cleaved Cell Lymphoma, Burkitt's Type 8
Malignant Lymphoma, Burkitt's Type 8
 
Small Non-Cleaved Cell Lymphoma 48
Small Non-Cleaved-Cell Lymphoma 62
Burkitts Lymphoma 10
Lymphatic Cancer 62
Burkitt's Tumor 8
Lymphoid Cancer 8
Bl 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
burkitt lymphoma:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:8584, DOID:0060058
OMIM46 113970
ICD9CM27 200.2
ICD10 via Orphanet26 C83.7
UMLS via Orphanet63 C0006413, C0079770
MESH via Orphanet35 D002051, D008228
ICD1025 C83.7

Related Diseases for Burkitt's Lymphoma

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Diseases related to Burkitt's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1256)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system lymphoma32.0BCL6
2intraocular lymphoma31.9CXCR5
3malt lymphoma31.8BCL6, CXCR5, IGHM
4peripheral t-cell lymphoma31.6BCL6, TCL1A
5follicular lymphoma31.4AICDA, IGHM, MYC, TCL1A, CXCR5, BCL6
6non-hodgkin lymphoma31.3AICDA, SH2D1A, MYC, TCL1A, CXCR5, BCL6
7hodgkin's lymphoma31.2AICDA, IGHM, SH2D1A, MPP1, TCL1A, IL13RA2
8b-cell lymphomas30.7AICDA, IGHM, MYC, TCL1A, CXCR5, BCL6
9prolymphocytic leukemia30.7MYC, TCL1A
10central nervous system lymphoma, primary30.7IGHM, CXCR5, BCL6
11plasmacytoma30.5AICDA, MYC, CXCR5, BCL6
12chronic lymphocytic leukemia30.4BCL6, TCL1A, IGHM, AICDA
13common variable immunodeficiency30.2SH2D1A, AICDA
14lymphoma aidsrelated30.2MYC, TCL1A, BCL6
15leukemia, acute lymphoblastic 330.2CXCR5, MYC
16agammaglobulinemia30.1SH2D1A, IGHM
17leukemia29.9AICDA, SH2D1A, MYC, TCL1A, CXCR5, BCL6
18myeloma29.7BCL2L11, BCL6, CXCR5, TCL1A, MYC, IGHM
19ipex syndrome28.9AICDA, IGHM, SH2D1A, MPP1, CXCR5, BCL6
20mantle cell lymphoma11.2
21anaplastic large cell lymphoma11.2
22cutaneous t cell lymphoma11.1
23small non-cleaved cell lymphoma11.0
24marginal zone b-cell lymphoma11.0
25gastric lymphoma11.0
26primary effusion lymphoma11.0
27adult t-cell leukemia11.0
28angioimmunoblastic t-cell lymphoma10.9
29thyroiditis10.9
30mediastinitis10.9
31primary malignant lymphoma10.8
32intravascular large b-cell lymphoma10.8
33thyroid lymphoma10.8
34panniculitis10.8
35sarcoma10.8
36cerebritis10.8
37subcutaneous panniculitis-like t-cell lymphoma10.7
38breast lymphoma10.7
39cerebral lymphoma10.7
40gastrointestinal lymphoma10.7
41nodular lymphocyte predominant hodgkin lymphoma10.7
42enteropathy-associated t-cell lymphoma10.7
43mycosis fungoides10.7
44primary mediastinal large b-cell lymphoma10.7
45diffuse large b-cell lymphoma10.7
46composite lymphoma10.7
47testicular lymphoma10.7
48hepatosplenic t-cell lymphoma10.6
49lymphomatoid papulosis10.6
50alk-positive anaplastic large cell lymphoma10.6

Graphical network of the top 20 diseases related to Burkitt's Lymphoma:



Diseases related to burkitt's lymphoma

Symptoms for Burkitt's Lymphoma

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Symptoms by clinical synopsis from OMIM:

113970

Clinical features from OMIM:

113970

HPO human phenotypes related to Burkitt's Lymphoma:

id Description Frequency HPO Source Accession
1 lymphoma HP:0002665

Drugs & Therapeutics for Burkitt's Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Burkitt's Lymphoma

Search NIH Clinical Center for Burkitt's Lymphoma

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Burkitt's Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Burkitt's Lymphoma

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Genetic tests related to Burkitt's Lymphoma:

id Genetic test Affiliating Genes
1 Burkitt Lymphoma22

Anatomical Context for Burkitt's Lymphoma

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MalaCards organs/tissues related to Burkitt's Lymphoma:

32
B cells, T cells, Lymph node, Testes, Bone, Breast, Bone marrow, Ovary, Colon, Kidney, Liver, Small intestine, Thyroid, Tongue, Brain, Heart, Pancreas, Prostate, B lymphoblasts, Endothelial, Appendix

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Burkitt's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Burkitt's Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Burkitt's Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7BCL2L11, BCL6, MYC, IGHM, AICDA
2MP:00028737.8IGHM, MYC, MYBL1, BCL6, BCL2L11, AICDA
3MP:00053767.3SH2D1A, GALK1, BCL2L11, BCL6, IL13RA2, MYBL1
4MP:00053847.3BCL2L11, AICDA, IGHM, MPP1, MYC, MYBL1
5MP:00053897.1MPP1, POLM, MYC, MYBL1, TCL1A, BCL6
6MP:00053976.3CXCR5, BCL2L11, BCL6, IL13RA2, MYBL1, MYC
7MP:00053876.2BCL6, IL13RA2, CXCR5, POLM, MYBL1, MYC

Publications for Burkitt's Lymphoma

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Articles related to Burkitt's Lymphoma:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Pediatric Burkitt's Lymphoma and Diffuse B-Cell Lymphoma: Are Surveillance Scans Required? (24087880)
2013
2
Burkitt's lymphoma treatment in a rural hospital in Sierra Leone. (24021903)
2013
3
Primary endobronchial Burkitt's lymphoma in a child: a case report. (23548894)
2013
4
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis. (24013231)
2013
5
PEG10 promotes the migration of human Burkitt's lymphoma cells by up-regulating the expression of matrix metalloproteinase-2 and -9. (22673314)
2012
6
Epidemiology of Burkitt's lymphoma in Northwest Province, Cameroon, 2003-2010. (22595214)
2012
7
Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics. (22241218)
2012
8
Comparative proteomic analysis implicates COMMD proteins as Epstein-Barr virus targets in the BL41 Burkitt's lymphoma cell line. (21615174)
2011
9
A case report of fatal tumor lysis syndrome after chemotherapy in a pregnant patient with Burkitt's lymphoma. (21481095)
2011
10
Burkitt's lymphoma in pregnancy with bilateral breast involvement: case report with review of the literature. (20838063)
2010
11
Burkitt's lymphoma in early pregnancy. (20048180)
2010
12
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response. (20723265)
2010
13
Novel lymphoid neoplasms--the borderland between diffuse large B-cell lymphoma and Burkitt's lymphoma. (19570750)
2009
14
Tumor lysis and acute renal failure in Burkitt's lymphoma: A review on pathophysiology and management. (20436725)
2009
15
Identification of genes deregulated during serum-free medium adaptation of a Burkitt's lymphoma cell line. (18211290)
2008
16
The curious case of the tumour virus: 50 years of Burkitt's lymphoma. (19008891)
2008
17
Primary cardiac onset of disseminated Burkitt's lymphoma. (18066547)
2008
18
Second Epstein-Barr virus-associated Burkitt's lymphoma of the CNS in a child with progressive renal failure. (18565896)
2008
19
Burkitt's lymphoma-- what is new? (18814529)
2008
20
Pilot study of sodium phenylbutyrate as adjuvant in cyclophosphamide-resistant endemic Burkitt's lymphoma. (17915270)
2007
21
Burkitt's lymphoma: conversion from lymphoma negative to lymphoma positive status over 2 months in a patient with acquired immunodeficiency syndrome (AIDS). (18091062)
2007
22
Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer. (17287852)
2007
23
Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. (17703817)
2007
24
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells. (17214905)
2007
25
Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model. (16288493)
2006
26
Burkitt'S lymphoma mimicking a primary gynecologic tumor. (17197360)
2006
27
Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (16614233)
2006
28
Cytomorphology and immunophenotyping of Burkitt's lymphoma presenting as a breast mass. (16509847)
2006
29
Sporadic Burkitt's lymphoma of the jaws: the essentials of prompt life-saving referral and management. (15763034)
2005
30
Burkitt's lymphoma: an unusual cause of obstructive jaundice. (16234085)
2005
31
Burkitt's lymphoma: an unusual cause of lip numbness. (15819153)
2005
32
Variable problems in lymphomas: CASE 1. Burkitt's lymphoma presenting with central airway obstruction. (16258109)
2005
33
Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus. (15287031)
2004
34
Combined polymerase chain reaction methods to detect c-myc/IgH rearrangement in childhood Burkitt's lymphoma for minimal residual disease analysis. (15257933)
2004
35
Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells. (12584570)
2003
36
Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways. (12464623)
2003
37
Distinct patterns of mitogen-activated protein kinase phosphorylation and Epstein-Barr virus gene expression in Burkitt's lymphoma cell lines versus B lymphoblastoid cell lines. (12206304)
2002
38
A Myc-associated zinc finger protein-related factor binding site is required for the deregulation of c-myc expression by the immunoglobulin heavy chain gene enhancers in Burkitt's lymphoma. (11777933)
2002
39
Hodgkin's disease after treatment for Burkitt's lymphoma: case report. (12002116)
2001
40
Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line. (11526098)
2001
41
An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line. (10997876)
2000
42
Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation. (10969772)
2000
43
Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent. (10946276)
2000
44
The AT-rich region between -54 to -66 is important for the promoter activity of interleukin-10 in Epstein-Barr virus positive Burkitt's lymphoma cells. (11196656)
1999
45
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
46
CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells. (8695856)
1996
47
Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma. (8670211)
1996
48
Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines. (7749063)
1995
49
The A-myb gene is preferentially expressed in tonsillar CD38+, CD39-, and sIgM- B lymphocytes and in Burkitt's lymphoma cell lines. (8021494)
1994
50
Generation of a variant t(2;8) translocation of Burkitt's lymphoma by site-specific recombination via the kappa light-chain joining signals. (3110600)
1987

Variations for Burkitt's Lymphoma

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Clinvar genetic disease variations for Burkitt's Lymphoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1MYCNM_002467.4(MYC): c.214C> T (p.Pro72Ser)single nucleotide variantPathogenicrs28933407GRCh37Chr 8, 128750677: 128750677
2MYCNM_002467.4(MYC): c.302A> C (p.Asn101Thr)single nucleotide variantPathogenicrs121918683GRCh37Chr 8, 128750765: 128750765
3MYCNM_002467.4(MYC): c.162G> C (p.Glu54Asp)single nucleotide variantPathogenicrs121918684GRCh37Chr 8, 128750625: 128750625
4MYCNM_002467.4(MYC): c.220C> G (p.Pro74Ala)single nucleotide variantPathogenicrs121918685GRCh37Chr 8, 128750683: 128750683

Expression for genes affiliated with Burkitt's Lymphoma

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Expression patterns in normal tissues for genes affiliated with Burkitt's Lymphoma

Search GEO for disease gene expression data for Burkitt's Lymphoma.

Pathways for genes affiliated with Burkitt's Lymphoma

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Pathways related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4BCL2L11, BCL6
29.2BCL6, SH2D1A, AICDA
3
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.2BCL2L11, BCL6, MYC
49.2IGHM, BCL6, BCL2L11
58.4BCL6, IL13RA2, MYBL1, AICDA

Compounds for genes affiliated with Burkitt's Lymphoma

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1suberoylanilide hydroxamic acid4410.0BCL2L11, MYC
2depsipeptide449.7BCL2L11, MYC
3cytidine44 24 1111.3BCL6, MYC, AICDA
4imatinib44 50 1111.2MYC, BCL6, BCL2L11
5cycloheximide448.8BCL2L11, BCL6, MYC, AICDA
6estrogen448.4BCL2L11, BCL6, MYBL1, MYC, AICDA

GO Terms for genes affiliated with Burkitt's Lymphoma

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Biological processes related to Burkitt's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328010.0BCL2L11, MYC
2somatic hypermutation of immunoglobulin genesGO:0164469.4POLM, AICDA
3B cell differentiationGO:0301838.8BCL6, POLM, AICDA

Products for genes affiliated with Burkitt's Lymphoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Burkitt's Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet