BMS
MCID: BRN009
MIFTS: 54

Burning Mouth Syndrome (BMS) malady

Summaries for Burning Mouth Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. the pain may affect the tongue, lips, palate, or throughout the mouth. allergies, nerve damage, irritation, stress, among other things can cause burning mouth syndrome, however in many cases the underlying cause can not be identified. the condition may respond to interventions and treatments, may resolve spontaneously, or may persist for months to years.  last updated: 11/12/2010

MalaCards: Burning Mouth Syndrome, also known as stomatodynia, is related to parkinson's disease and pain disorder. An important gene associated with Burning Mouth Syndrome is TRPV1 (transient receptor potential cation channel, subfamily V, member 1), and among its related pathways are PEDF Induced Signaling and MAPK signaling pathway. The compounds pentoxifylline and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and heart, and related mouse phenotypes are adipose tissue and respiratory system.

Wikipedia:64 Burning mouth syndrome (BMS also termed glossodynia,orodynia,oral... more...

Aliases & Classifications for Burning Mouth Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

burning mouth syndrome 8 43 61
stomatodynia 43 61
burning mouth disorder 43
stomatopyrosis 8
orodynia 8
bms 43


External Ids:

Disease Ontology8 DOID:4331
MeSH35 D002054
NCIt40 C62545

Related Diseases for Burning Mouth Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Burning Mouth Syndrome:



Diseases related to burning mouth syndrome

Clinical Features for Burning Mouth Syndrome

Drugs & Therapeutics for Burning Mouth Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Burning Mouth Syndrome

Drug clinical trials:

Search ClinicalTrials for Burning Mouth Syndrome

Search NIH Clinical Center for Burning Mouth Syndrome

Search CenterWatch for Burning Mouth Syndrome

Genetic Tests for Burning Mouth Syndrome

Anatomical Context for Burning Mouth Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Burning Mouth Syndrome:

33
Skin, Tongue, Heart, Colon, Thyroid, T cells, B cells, Trigeminal ganglion

Animal Models for Burning Mouth Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Burning Mouth Syndrome

Sources:
51PubMed
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Articles related to Burning Mouth Syndrome:

(show top 50)    (show all 355)
idTitleAuthorsYear
1
Burning mouth syndrome. (23809306)
2013
2
Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. (22957483)
2013
3
"Burning mouth syndrome in Parkinson's disease: dopamine as cure or cause?" Letter to the editor reply. (23054065)
2012
4
Effect of an herbal compound for treatment of burning mouth syndrome: randomized, controlled, double-blind clinical trial. (22669143)
2012
5
Burning mouth syndrome: a discussion of a complex pathology. (23050296)
2012
6
Application of a capsaicin rinse in the treatment of burning mouth syndrome. (21743415)
2012
7
Relationship between oxidative stress and "burning mouth syndrome" in female patients: a scientific hypothesis. (23047505)
2012
8
Pain and pain behavior in burning mouth syndrome: a pain diary study. (22558611)
2012
9
Is effect of low-level laser therapy in patients with burning mouth syndrome result of a placebo? (21492001)
2011
10
Burning mouth syndrome and vitamin B12 deficiency. (20569292)
2011
11
The dubious effect of milnacipran for the treatment of burning mouth syndrome. (21738026)
2011
12
Complementary and alternative medical therapies in patients with burning mouth syndrome. (21417931)
2011
13
Burning mouth syndrome. (20690412)
2010
14
Different therapeutic strategies for burning mouth syndrome: preliminary data. (20701667)
2010
15
Response to topical clonazepam in patients with burning mouth syndrome: a clinical study. (22750263)
2010
16
Cognitive profile of patients with burning mouth syndrome in the Japanese population. (20652795)
2010
17
Salivary cortisol, stress and quality of life in patients with burning mouth syndrome. (19453816)
2009
18
Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome. (19192048)
2009
19
Letter to the editor: Burning mouth syndrome and risk of allergy. (19333181)
2009
20
An open-label, noncomparative, dose escalation pilot study of the effect of paroxetine in treatment of burning mouth syndrome. (18996028)
2009
21
Contribution of neuroinflammation in burning mouth syndrome: indications from benzodiazepine use. (18837729)
2008
22
Burning mouth syndrome. (18985004)
2008
23
Management of burning mouth syndrome: systematic review and management recommendations. (17379153)
2007
24
An up-to-date view on burning mouth syndrome. (17625490)
2007
25
Causative or precipitating aspects of burning mouth syndrome: a case-control study. (16918597)
2006
26
Burning mouth syndrome: etiology. (17119782)
2006
27
Salivary interleukin-6 and tumor necrosis factor-alpha in patients with burning mouth syndrome. (16700748)
2006
28
Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. (15858863)
2005
29
Nocturia and the burning mouth syndrome (BMS) in the elderly. (15985299)
2005
30
The diagnosis of burning mouth syndrome represents a challenge for clinicians. (15895840)
2005
31
Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. (15911160)
2005
32
Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or gustatory disturbances. (15126133)
2004
33
Capsaicin in burning mouth syndrome: titration strategies. (15291279)
2004
34
Correlations among mood disorder, serum interleukin-2 and interleukin-6 in patients with burning mouth syndrome]. (14650995)
2003
35
Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. (12110042)
2002
36
Drug points: Dysgeusia and burning mouth syndrome by eprosartan. (12458247)
2002
37
The secretion of parotid saliva as stimulated by 10% citric acid is not related to precipitating factors in burning mouth syndrome. (11168857)
2001
38
Burning mouth syndrome: prevalence and associated factors. (10478959)
1999
39
A review of burning mouth syndrome. (10431669)
1999
40
Burning mouth syndrome: approach to successful management. (10478025)
1998
41
Burning mouth syndrome (BMS) and the concept of alexithymia--a preliminary study. (9234183)
1997
42
Burning mouth syndrome. (8725589)
1996
43
Personality characteristics of patients with resistant burning mouth syndrome. (7740935)
1995
44
Burning mouth syndrome. Successful treatment with combined psychotherapy and psychopharmacotherapy. (8522154)
1995
45
Burning mouth syndrome due to xerostomia and/or a tartar-control dentifrice: report of a case. (2069761)
1991
46
Oral medicine in practice: burning mouth syndrome. (2789896)
1989
47
Burning mouth syndrome due to nicotinic acid esters and sorbic acid. (3191688)
1988
48
Contact allergy to denture materials in the burning mouth syndrome. (3284710)
1988
49
Clinical features of burning mouth syndrome. (3468464)
1987
50
Skin sensitivity to denture base materials in the burning mouth syndrome. (467032)
1979

Genetic Variations for Burning Mouth Syndrome

Expression for genes affiliated with Burning Mouth Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Burning Mouth Syndrome

Search GEO for disease gene expression data for Burning Mouth Syndrome.

Pathways for genes affiliated with Burning Mouth Syndrome

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems, 12EMD Millipore, 60Tocris Bioscience, 54Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CD14
2
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10.2NGF
310.2TLR2
4
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10.2TLR2
510.2TLR2
6
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10.2IL2
710.1SLC6A4
89.7IL6, IL1B
99.6IL1B, TNF
109.6TLR2, CD14, IL6
11
Hide members
9.5TLR2, IL1B, IL2
129.5IL6, IL1B, CD14
139.4P2RX3, TRPV1, SCN9A
149.4IL6, IL1B, TLR2
15
Hide members
9.4IL6, IL1B, TLR2
16
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9.4IL1B, IL6, IL2
179.4IL1B, CD14, TNF
18
Hide members
9.4IL1B, NGF, TNF
199.3IL2, IL6, TNF
209.3TLR2, TNF, IL1B
219.3IL1B, TNF, TLR2
229.3TLR2, NGF, IL6, IL2
239.2TNF, IL1B, IL6
249.2TNF, IL1B, IL6
259.2TNF, IL1B, IL6
26
Hide members
9.2IL6, IL1B, TNF
27
Hide members
9.1TLR2, TNF, CD14, IL1B
289.0TNF, CD14, IL1B, IL6
299.0TNF, CD14, IL1B, IL6
309.0TNF, CD14, IL1B, IL6
31
Hide members
9.0IL6, IL1B, CD14, TNF
328.9IL2, IL6, IL1B, TNF
338.9IL2, IL6, IL1B, TNF
34
Hide members
8.8TLR2, TNF, CD14, IL1B, IL2
35
Immune response Bacterial infections in normal airways
Hide members
8.7TLR2, TNF, CD14, IL1B, IL6
368.7TLR2, TNF, CD14, IL1B, IL6
378.7TLR2, TNF, CD14, IL1B, IL6
388.7TLR2, TNF, CD14, IL1B, IL6
39
Hide members
8.7TLR2, TNF, CD14, IL1B, IL6
40
Development PDGF signaling via STATs and NF-kB
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8.7IL2, IL6, IL1B, CD14, TNF
41
Hide members
8.7TLR2, TNF, IL1B, IL6, IL2
42
Hide members
8.7TLR2, TNF, IL1B, IL6, IL2
43
Hide members
8.7TLR2, TNF, IL1B, IL6, IL2
44
Hide members
8.7IL2, IL6, IL1B, TNF, TLR2
45
Hide members
8.4TLR2, TNF, CD14, IL1B, IL6, IL2
467.5SLC6A4, TNF, TF, NGF, IL1B, IL6

Compounds for genes affiliated with Burning Mouth Syndrome

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB
See all sources

Compounds related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.6CD14
2cycloheximide4510.6TLR2
3prednisolone45 29 1112.4NGF, CD14
4pge24510.4IL2, TRPV1
5gm-csf45 2911.2TNF, CD14
6muramyl dipeptide45 2910.9IL1B, CD14, TLR2
7cyclosporin a45 29 6011.9TF, TRPV1, NGF, CD14
8indomethacin45 60 29 1112.8TAC1, NGF
9bucillamine459.7IL1B, IL6, IL2
10norepinephrine45 11 2411.7SLC6A4, TAC1
11hbd2459.6TLR2, IL1B, IL6
12hcec459.6TLR2, NGF, IL6
13toxin-1459.5TNF, IL1B, IL2
14anakinra45 1110.5TNF, IL1B, IL6
15vesnarinone459.5IL6, IL1B, TNF
16gold sodium thiomalate459.5TNF, CD14, IL1B, IL2
17mip 1alpha459.4IL6, IL1B, TNF
18taurine chloramine459.4IL2, IL6, IL1B, TNF
19il-12459.3TNF, IL1B, IL6, IL2
20poly(i-c)459.3IL6, IL1B, TNF, TLR2
21ccl345 2910.3TLR2, TNF, IL1B, IL6
22resiniferatoxin45 2910.3TRPV1, TAC1, P2RX3
23polymyxin b459.2TLR2, TNF, CD14, IL1B, IL6
24dexamethasone45 50 29 1112.2TAC1, IL6, CD14, TLR2
25lipoteichoic acid459.2TLR2, TNF, CD14, IL1B, IL6
26pdtc459.2TNF, NGF, IL1B, IL6
27peptidoglycan45 2910.1TLR2, TNF, CD14, IL1B, IL6
28triptolide459.1TNF, CD14, IL1B, IL6, IL2
29leukotriene b445 60 2411.1TLR2, TNF, TRPV1, IL1B, IL6
30polyinosinic-polycytidylic acid459.1IL2, IL6, IL1B, TNF, TLR2
31neopterin459.1TNF, CD14, IL1B, IL6, IL2
32il 10459.1TLR2, TNF, IL1B, IL6, IL2
33thalidomide45 50 60 1112.1TNF, IL1B, IL6, IL2
34anisomycin45 1110.0IL6, IL1B, NGF, TNF
35sp 60012545 6010.0IL6, IL1B, TNF, TLR2
36capsaicin45 2910.0P2RX3, TAC1, NGF, TRPV1
37herbimycin a45 609.9TNF, NGF, CD14, IL1B, IL6, IL2
38pd 98,059458.8TLR2, TNF, NGF, CD14, IL1B, IL6
39rantes458.8TLR2, TNF, CD14, IL1B, IL6, IL2
40triamcinolone acetonide45 299.8TLR2, TF, TAC1
41dopamine45 29 11 2411.7ARTN, TRPV1, TAC1, SLC6A4
42calcitriol45 60 11 2411.6TLR2, TNF, NGF, CD14, IL1B, IL6
43sb 20358045 609.6IL6, IL1B, NGF, TNF, TLR2
44prostacyclin458.5TNF, TF, NGF, IL1B, TAC1
45epinephrine45 11 2410.5TF, NGF, IL6, TAC1, SLC6A4
46prostaglandin458.3TLR2, TNF, TRPV1, IL1B, IL6, TAC1
47vegf458.2TLR2, TNF, TF, NGF, CD14, IL1B
48actinomycin d458.0TLR2, TNF, NGF, IL1B, IL6, IL2
49nitric oxide45 11 249.6TLR2, TNF, TRPV1, IL1B, IL6, TAC1
50histamine45 29 249.5TAC1, TLR2, TNF, TF, NGF, CD14

GO Terms for genes affiliated with Burning Mouth Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.9SLC6A4, P2RX3, CD14, TNF
2extracellular regionGO:0055767.0TNF, TF, NGF, CD14, IL1B, IL6
3extracellular spaceGO:0056156.9TAC1, TNF, ARTN, NGF, CD14, IL1B

Biological processes related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.3TLR2, CD14
2positive regulation of immunoglobulin secretionGO:05102410.1IL6, IL2
3sequestering of triglycerideGO:03073010.0IL1B, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.0IL1B, TNF
5epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.9TNF, IL6
6positive regulation of heterotypic cell-cell adhesionGO:0341169.9IL1B, TNF
7positive regulation of fever generationGO:0316229.9IL1B, TNF
8negative regulation of lipid storageGO:0108889.9TNF, IL6
9positive regulation of cytokine secretionGO:0507159.9TLR2, TNF, CD14
10positive regulation of chemokine biosynthetic processGO:0450809.9IL1B, TNF
11response to electrical stimulusGO:0516029.8IL6, NGF
12regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.8TNF, IL1B
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IL1B, TNF
14positive regulation of chemokine productionGO:0327229.8IL6, TNF, TLR2
15negative regulation of lipid catabolic processGO:0509959.8IL1B, TNF
16negative regulation of growth of symbiont in hostGO:0441309.8TLR2, TNF
17defense response to Gram-positive bacteriumGO:0508309.7IL6, TNF, TLR2
18behavioral response to painGO:0482669.7SCN9A, P2RX3
19response to mechanical stimulusGO:0096129.7TNF, NGF, IL6
20positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR2, TNF, IL1B
21lipopolysaccharide-mediated signaling pathwayGO:0316639.7IL1B, TNF, TLR2
22response to glucocorticoid stimulusGO:0513849.7TNF, NGF, IL6
23response to heatGO:0094089.7CD14, IL6, P2RX3
24positive regulation of interferon-gamma productionGO:0327299.7TNF, IL1B, IL2
25positive regulation of acute inflammatory responseGO:0026759.5TAC1, IL6
26response to ATPGO:0331989.4IL1B, P2RX3
27positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4TNF, NGF, IL1B, IL6
28positive regulation of nitric oxide biosynthetic processGO:0454299.4IL6, IL1B, TNF, TLR2
29regulation of action potential in neuronGO:0192289.4P2RX3, SCN9A
30positive regulation of interleukin-6 productionGO:0327559.4TLR2, TNF, IL1B, IL6
31positive regulation of NF-kappaB transcription factor activityGO:0510929.4IL6, IL1B, TNF, TLR2
32response to drugGO:0424939.3TNF, NGF, IL6, SLC6A4
33response to lipopolysaccharideGO:0324969.1NGF, IL6, TAC1
34positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TLR2, TNF, IL1B, IL6, IL2
35inflammatory responseGO:0069547.8TAC1, TLR2, TNF, SCN9A, NGF, CD14

Molecular functions related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:0708919.9CD14, TLR2
2cytokine activityGO:0051258.9IL2, IL6, IL1B, TNF
3growth factor activityGO:0080838.6ARTN, NGF, IL6, IL2

Products for genes affiliated with Burning Mouth Syndrome

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Sources for Burning Mouth Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet