BMS
MCID: BRN009
MIFTS: 56

Burning Mouth Syndrome (BMS) malady

Summaries for Burning Mouth Syndrome

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. the pain may affect the tongue, lips, palate, or throughout the mouth. allergies, nerve damage, irritation, stress, among other things can cause burning mouth syndrome, however in many cases the underlying cause can not be identified. the condition may respond to interventions and treatments, may resolve spontaneously, or may persist for months to years.  last updated: 11/12/2010

MalaCards: Burning Mouth Syndrome, also known as stomatodynia, is related to neuropathy and pain disorder. An important gene associated with Burning Mouth Syndrome is TRPV1 (transient receptor potential cation channel, subfamily V, member 1), and among its related pathways are PEDF Induced Signaling and MAPK signaling pathway. The compounds pentoxifylline and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and heart, and related mouse phenotypes are adipose tissue and respiratory system.

Wikipedia:63 Burning mouth syndrome (BMS also termed glossodynia,orodynia,oral... more...

Aliases & Classifications for Burning Mouth Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

burning mouth syndrome 8 42 60
stomatodynia 42 60
burning mouth disorder 42
stomatopyrosis 8
orodynia 8
bms 42


External Ids:

Disease Ontology8 DOID:4331
MeSH34 D002054
NCIt39 C62545

Related Diseases for Burning Mouth Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Burning Mouth Syndrome family:

Burning Mouth Syndrome Type 3

Diseases related to Burning Mouth Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.5SCN9A, TRPV1, NGF, TAC1
2pain disorder30.3SCN9A, NGF, TAC1
3parkinson's disease30.3NGF, SLC6A4, TAC1, ARTN
4dermatitis30.1TAC1
5diabetic neuropathy30.1NGF, TRPV1
6diabetes mellitus30.1TF, IL1B, CD14, TAC1, NGF, IL6
7lung cancer29.8IL2
8ischemia29.8CD14, TRPV1
9bulimia nervosa29.8SLC6A4
10hypertension29.8SLC6A4, TAC1
11acute leukemia29.8IL2, CD14
12breast cancer29.8CD14, IL2, TAC1
13eosinophilia29.8CD14, IL2, NGF
14myeloma29.8CD14, IL1B, IL6, IL2
15vascular disease29.8NGF, IL2, TNF, IL6, TF, IL1B
16leukemia29.8CD14, IL1B, NGF, TNF, TLR2, IL6
17burns11.4
18lichen planus10.4
19mouth disease10.4
20burning mouth syndrome type 310.4
21glossodynia10.4
22oral submucous fibrosis10.2
23trigeminal neuralgia10.2
24glossitis10.2
25aplastic anemia10.2
26hemophilia10.2
27hemophilia b10.1
28coronary thrombosis10.1
29exfoliation syndrome10.1
30restless legs syndrome10.1
31alexithymia10.1
32aphthous stomatitis10.1
33type 1 diabetes mellitus10.1
34down syndrome10.1
35autonomic nervous system disease10.1
36contact dermatitis10.1
37hypothyroidism10.1
38lichen disease10.1
39mood disorder10.1
40nervous system disease10.1
41peripheral neuropathy10.1
42personality disorder10.1
43stomatitis10.1
44thyroiditis10.1
45tongue disease10.1
46urticaria10.1
47vitamin b12 deficiency10.1
48cicatricial pemphigoid10.0
49rhinitis10.0TAC1
50complex regional pain syndrome10.0TAC1

Graphical network of the top 20 diseases related to Burning Mouth Syndrome:



Diseases related to burning mouth syndrome

Clinical Features for Burning Mouth Syndrome

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Drugs & Therapeutics for Burning Mouth Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Burning Mouth Syndrome

Drug clinical trials:

Search ClinicalTrials for Burning Mouth Syndrome

Search NIH Clinical Center for Burning Mouth Syndrome

Search CenterWatch for Burning Mouth Syndrome

Genetic Tests for Burning Mouth Syndrome

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Anatomical Context for Burning Mouth Syndrome

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32MalaCards
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MalaCards organs/tissues related to Burning Mouth Syndrome:

32
Tongue, Testes, Heart, Colon, Thyroid, Skin

Animal Models for Burning Mouth Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Burning Mouth Syndrome:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.1TRPV1
2MP:00053889.3IL6, P2RX3
3MP:00020068.8TNF, TRPV1, IL1B, IL6, IL2
4MP:00036318.6SCN9A, ARTN, TRPV1, P2RX3, SLC6A4
5MP:00107718.1TLR2, SCN9A, IL6, TAC1, P2RX3, SLC6A4
6MP:00053787.7TLR2, TNF, TF, TRPV1, NGF, CD14
7MP:00053877.7TNF, TRPV1, CD14, IL1B, IL6, IL2
8MP:00053766.9TRPV1, TF, TNF, TLR2, NGF, CD14
9MP:00053866.8TLR2, TNF, SCN9A, TRPV1, NGF, IL6
10MP:00107686.8TLR2, TNF, SCN9A, TF, NGF, CD14
11MP:00053856.7SLC6A4, TLR2, TNF, TRPV1, NGF, IL1B

Publications for Burning Mouth Syndrome

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50PubMed
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Articles related to Burning Mouth Syndrome:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Management of burning mouth syndrome: a clinical experience. (24353760)
2013
2
Defining and diagnosing burning mouth syndrome: Perceptions of directors of North American postgraduate oral medicine and orofacial pain programs. (24080929)
2013
3
Laser acupuncture in the treatment of burning mouth syndrome: a pilot study. (24014212)
2013
4
MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. (23411403)
2013
5
Anxiety, depression, and pain in burning mouth syndrome: first chicken or egg? (22607629)
2012
6
Pathophysiology of primary burning mouth syndrome. (22030140)
2012
7
Fungiform papillae density in patients with burning mouth syndrome and xerostomia. (22143737)
2012
8
Treatment of burning mouth syndrome with amisulpride. (22719802)
2012
9
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. (23110271)
2012
10
Dopa responsive burning mouth syndrome: restless mouth syndrome or oral variant of restless legs syndrome? (22819057)
2012
11
A case of unilateral burning mouth syndrome of neuropathic origin. (20807251)
2011
12
Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial. (20711135)
2011
13
Salivary concentrations of nickel and chromium in patients with burning mouth syndrome. (21489358)
2011
14
Burning mouth syndrome: is acupuncture a therapeutic possibility? (20596066)
2010
15
Salivary and serum levels of substance P, neurokinin A and calcitonin gene related peptide in burning mouth syndrome. (20038912)
2010
16
The low level laser therapy in the management of neurological burning mouth syndrome. A pilot study. (22238700)
2010
17
Critical commentary 2: steroid dysregulation and stomatodynia (burning mouth syndrome). (19639099)
2009
18
Critical commentary 1: steroid dysregulation and stomatodynia (burning mouth syndrome). (19639098)
2009
19
Marked response of burning mouth syndrome to pregabalin treatment. (19747308)
2009
20
Comparison of treatment modalities in burning mouth syndrome. (20415927)
2009
21
Steroid dysregulation and stomatodynia (burning mouth syndrome). (19639097)
2009
22
Efficacy of moclobemide in burning mouth syndrome: a nonrandomized, open-label study. (18548844)
2008
23
Burning mouth syndrome possibly linked with an amalgam tattoo : clinical and ultrastructural evidence. (19049944)
2008
24
Two cases of burning mouth syndrome treated with olanzapine. (18588600)
2008
25
Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. (17582772)
2007
26
Burning mouth syndrome (stomatodynia). (17601771)
2007
27
Tongue pain: burning mouth syndrome vs Candida- associated lesion. (17577333)
2007
28
Burning mouth syndrome. (16733345)
2006
29
Topical capsaicin application and axon reflex vasodilatation of the tongue: neurogenic involvement in burning mouth syndrome. (17235416)
2006
30
Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. (14720197)
2004
31
Burning mouth syndrome in the Basque Country: a preliminary study of 30 cases. (12618668)
2003
32
Burning mouth syndrome and other oral sensory disorders: a unifying hypothesis. (14657979)
2003
33
Burning mouth syndrome: a guide for the general practitioner. (15055637)
2003
34
Update on burning mouth syndrome: overview and patient management. (12907696)
2003
35
Stomatodynia or burning mouth syndrome. (14670224)
2003
36
Burning mouth syndrome and vulvodynia coexisting in the same patient: a case report. (11928344)
2002
37
Sensory dysfunction in burning mouth syndrome. (12237182)
2002
38
Impact of criteria-based diagnosis of burning mouth syndrome on treatment outcome. (12455431)
2002
39
Burning mouth syndrome. (11603307)
2001
40
Lack of association between burning mouth syndrome and hematinic deficiencies. (11591532)
2001
41
Interventions for the treatment of burning mouth syndrome. (11687027)
2001
42
Oral lichen planus and the burning mouth syndrome. Is there a role for patch testing? (10908181)
2000
43
Burning mouth syndrome: a review of etiologies. (9237148)
1997
44
The burning mouth syndrome. (8543701)
1996
45
Burning mouth syndrome: the role of contact hypersensitivity. (8982420)
1996
46
Sensory and pain thresholds to orofacial argon laser stimulation in patients with chronic burning mouth syndrome. (8219522)
1993
47
Vitamin B status and response to replacement therapy in patients with burning mouth syndrome. (1776404)
1991
48
Psychophysical assessment of tactile, pain and thermal sensory functions in burning mouth syndrome. (3822502)
1987
49
Local treatment with aluminium hydroxide solution in burning mouth syndrome. (6590157)
1984
50
Burning mouth syndrome. (6620512)
1983

Genetic Variations for Burning Mouth Syndrome

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Expression for genes affiliated with Burning Mouth Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Burning Mouth Syndrome

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Pathways for genes affiliated with Burning Mouth Syndrome

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience, 53Reactome, 4Cell Signaling Technology
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Pathways related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CD14
2
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10.2NGF
310.2TLR2
4
Hide members
10.2TLR2
510.2TLR2
6
Hide members
10.2IL2
710.1SLC6A4
89.7IL6, IL1B
99.6IL1B, TNF
109.6TLR2, CD14, IL6
11
Hide members
9.5TLR2, IL1B, IL2
129.5IL6, IL1B, CD14
139.4P2RX3, TRPV1, SCN9A
149.4IL6, IL1B, TLR2
15
Hide members
9.4IL6, IL1B, TLR2
16
Hide members
9.4IL1B, IL6, IL2
179.4IL1B, CD14, TNF
18
Hide members
9.4IL1B, NGF, TNF
199.3IL2, IL6, TNF
209.3TLR2, TNF, IL1B
219.3IL1B, TNF, TLR2
229.3TLR2, NGF, IL6, IL2
239.2TNF, IL1B, IL6
249.2TNF, IL1B, IL6
259.2TNF, IL1B, IL6
26
Hide members
9.2IL6, IL1B, TNF
27
Hide members
9.1TLR2, TNF, CD14, IL1B
289.0TNF, CD14, IL1B, IL6
299.0TNF, CD14, IL1B, IL6
309.0TNF, CD14, IL1B, IL6
31
Hide members
9.0IL6, IL1B, CD14, TNF
328.9IL2, IL6, IL1B, TNF
338.9IL2, IL6, IL1B, TNF
34
Hide members
8.8TLR2, TNF, CD14, IL1B, IL2
35
Immune response Bacterial infections in normal airways
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8.7TLR2, TNF, CD14, IL1B, IL6
368.7TLR2, TNF, CD14, IL1B, IL6
378.7TLR2, TNF, CD14, IL1B, IL6
388.7TLR2, TNF, CD14, IL1B, IL6
39
Hide members
8.7TLR2, TNF, CD14, IL1B, IL6
40
Development PDGF signaling via STATs and NF-kB
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8.7IL2, IL6, IL1B, CD14, TNF
41
Hide members
8.7TLR2, TNF, IL1B, IL6, IL2
42
Hide members
8.7TLR2, TNF, IL1B, IL6, IL2
43
Hide members
8.7TLR2, TNF, IL1B, IL6, IL2
44
Hide members
8.7IL2, IL6, IL1B, TNF, TLR2
45
Hide members
8.4TLR2, TNF, CD14, IL1B, IL6, IL2
467.5SLC6A4, TNF, TF, NGF, IL1B, IL6

Compounds for genes affiliated with Burning Mouth Syndrome

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.6CD14
2cycloheximide4410.6TLR2
3prednisolone44 28 1112.4CD14, NGF
4pge24410.4TRPV1, IL2
5gm-csf44 2811.2CD14, TNF
6muramyl dipeptide44 2810.9CD14, TLR2, IL1B
7cyclosporin a44 28 5911.9NGF, TRPV1, TF, CD14
8indomethacin44 59 28 1112.8NGF, TAC1
9bucillamine449.7IL2, IL1B, IL6
10norepinephrine44 11 2411.7TAC1, SLC6A4
11hbd2449.6TLR2, IL6, IL1B
12hcec449.6TLR2, NGF, IL6
13toxin-1449.5IL1B, IL2, TNF
14anakinra44 1110.5IL1B, IL6, TNF
15vesnarinone449.5IL1B, IL6, TNF
16gold sodium thiomalate449.5IL2, IL1B, CD14, TNF
17mip 1alpha449.4TNF, IL1B, IL6
18taurine chloramine449.4IL2, IL6, IL1B, TNF
19il-12449.3TNF, IL1B, IL6, IL2
20poly(i-c)449.3IL1B, IL6, TNF, TLR2
21ccl344 2810.3TNF, TLR2, IL6, IL1B
22resiniferatoxin44 2810.3P2RX3, TRPV1, TAC1
23polymyxin b449.2IL1B, CD14, TNF, TLR2, IL6
24dexamethasone44 49 28 1112.2TAC1, IL6, TLR2, CD14
25lipoteichoic acid449.2IL6, IL1B, TNF, TLR2, CD14
26pdtc449.2TNF, IL1B, NGF, IL6
27peptidoglycan44 2810.1IL1B, TLR2, TNF, CD14, IL6
28triptolide449.1IL2, TNF, CD14, IL1B, IL6
29leukotriene b444 59 2411.1TLR2, IL6, TRPV1, IL1B, TNF
30polyinosinic-polycytidylic acid449.1TNF, IL6, TLR2, IL2, IL1B
31neopterin449.1IL6, IL2, IL1B, TNF, CD14
32il 10449.1TNF, IL1B, IL2, TLR2, IL6
33thalidomide44 49 59 1112.1TNF, IL1B, IL2, IL6
34anisomycin44 1110.0NGF, TNF, IL6, IL1B
35sp 60012544 5910.0IL6, IL1B, TNF, TLR2
36capsaicin44 2810.0TAC1, TRPV1, NGF, P2RX3
37herbimycin a44 599.9IL6, IL2, IL1B, CD14, NGF, TNF
38pd 98,059448.8CD14, NGF, TLR2, TNF, IL6, IL1B
39rantes448.8TNF, TLR2, CD14, IL1B, IL6, IL2
40triamcinolone acetonide44 289.8TF, TLR2, TAC1
41dopamine44 28 11 2411.7ARTN, TRPV1, TAC1, SLC6A4
42calcitriol44 59 11 2411.6TNF, NGF, CD14, IL1B, IL6, IL2
43sb 20358044 599.6TLR2, TNF, NGF, IL1B, IL6
44prostacyclin448.5IL1B, NGF, TNF, TAC1, TF
45epinephrine44 11 2410.5NGF, SLC6A4, TF, IL6, TAC1
46prostaglandin448.3TAC1, IL6, IL1B, TRPV1, TNF, TLR2
47vegf448.2TF, TNF, TLR2, NGF, CD14, IL1B
48actinomycin d448.0NGF, TAC1, IL2, IL6, IL1B, TLR2
49nitric oxide44 11 249.6TNF, TLR2, TRPV1, P2RX3, IL1B, TAC1
50histamine44 28 249.5IL6, CD14, NGF, TF, IL1B, IL2

GO Terms for genes affiliated with Burning Mouth Syndrome

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16Gene Ontology
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Cellular components related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.9SLC6A4, P2RX3, CD14, TNF
2extracellular regionGO:0055767.0TNF, TF, NGF, CD14, IL1B, IL6
3extracellular spaceGO:0056156.9TAC1, TNF, ARTN, NGF, CD14, IL1B

Biological processes related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.3TLR2, CD14
2positive regulation of immunoglobulin secretionGO:05102410.1IL6, IL2
3sequestering of triglycerideGO:03073010.0IL1B, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.0IL1B, TNF
5epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.9TNF, IL6
6positive regulation of heterotypic cell-cell adhesionGO:0341169.9IL1B, TNF
7positive regulation of fever generationGO:0316229.9IL1B, TNF
8negative regulation of lipid storageGO:0108889.9TNF, IL6
9positive regulation of cytokine secretionGO:0507159.9TLR2, TNF, CD14
10positive regulation of chemokine biosynthetic processGO:0450809.9IL1B, TNF
11response to electrical stimulusGO:0516029.8IL6, NGF
12regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.8TNF, IL1B
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IL1B, TNF
14positive regulation of chemokine productionGO:0327229.8IL6, TNF, TLR2
15negative regulation of lipid catabolic processGO:0509959.8IL1B, TNF
16negative regulation of growth of symbiont in hostGO:0441309.8TLR2, TNF
17defense response to Gram-positive bacteriumGO:0508309.7IL6, TNF, TLR2
18behavioral response to painGO:0482669.7SCN9A, P2RX3
19response to mechanical stimulusGO:0096129.7TNF, NGF, IL6
20positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR2, TNF, IL1B
21lipopolysaccharide-mediated signaling pathwayGO:0316639.7IL1B, TNF, TLR2
22response to glucocorticoid stimulusGO:0513849.7TNF, NGF, IL6
23response to heatGO:0094089.7CD14, IL6, P2RX3
24positive regulation of interferon-gamma productionGO:0327299.7TNF, IL1B, IL2
25positive regulation of acute inflammatory responseGO:0026759.5TAC1, IL6
26response to ATPGO:0331989.4IL1B, P2RX3
27positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4TNF, NGF, IL1B, IL6
28positive regulation of nitric oxide biosynthetic processGO:0454299.4IL6, IL1B, TNF, TLR2
29regulation of action potential in neuronGO:0192289.4P2RX3, SCN9A
30positive regulation of interleukin-6 productionGO:0327559.4TLR2, TNF, IL1B, IL6
31positive regulation of NF-kappaB transcription factor activityGO:0510929.4IL6, IL1B, TNF, TLR2
32response to drugGO:0424939.3TNF, NGF, IL6, SLC6A4
33response to lipopolysaccharideGO:0324969.1NGF, IL6, TAC1
34positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TLR2, TNF, IL1B, IL6, IL2
35inflammatory responseGO:0069547.8TAC1, TLR2, TNF, SCN9A, NGF, CD14

Molecular functions related to Burning Mouth Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:0708919.9CD14, TLR2
2cytokine activityGO:0051258.9IL2, IL6, IL1B, TNF
3growth factor activityGO:0080838.6ARTN, NGF, IL6, IL2

Products for genes affiliated with Burning Mouth Syndrome

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  • Antibodies
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Sources for Burning Mouth Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet