MCID: C4D002
MIFTS: 17

C4a Deficiency malady

Summaries for C4a Deficiency

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Sources:
66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Complement component 4 is a protein involved in the complement system. more...

MalaCards: C4a Deficiency is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with C4a Deficiency is C4A (complement component 4A (Rodgers blood group)), and among its related pathways are Allograft rejection and Staphylococcus aureus infection.

Description from OMIM:48 614380

Aliases & Classifications for C4a Deficiency

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48OMIM
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Aliases & Descriptions:

c4a deficiency 48


Related Diseases for C4a Deficiency

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18GeneCards, 19GeneDecks
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Diseases related to C4a Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.7C4A, HLA-DRB1
2lupus erythematosus10.5
3hepatitis b10.1
4hepatitis10.1
5diabetes mellitus10.0HLA-DRB1
6type 1 diabetes mellitus10.0C4A, HLA-DRB1
7hypersensitivity reaction type ii disease10.0C4A, HLA-DRB1

Graphical network of diseases related to C4a Deficiency:



Diseases related to c4a deficiency

Symptoms for C4a Deficiency

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48OMIM
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Symptoms by clinical synopsis from OMIM:

614380

Clinical features from OMIM:

614380

Drugs & Therapeutics for C4a Deficiency

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for C4a Deficiency

Drug clinical trials:

Search ClinicalTrials for C4a Deficiency

Search NIH Clinical Center for C4a Deficiency

Search CenterWatch for C4a Deficiency

Genetic Tests for C4a Deficiency

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Anatomical Context for C4a Deficiency

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Animal Models for C4a Deficiency or affiliated genes

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Publications for C4a Deficiency

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53PubMed
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Articles related to C4a Deficiency:

(show all 13)
idTitleAuthorsYear
1
C4A deficiency in children and adolescents with recurrent respiratory infections. (22406254)
2012
2
Influence of C4A deficiency on nonresponse to HBsAg vaccination: a new immune response gene. (12175637)
2002
3
C4A deficiency and nonresponse to hepatitis B vaccination. (12175635)
2002
4
C4A deficiency and elevated level of immune complexes: the mechanism behind increased susceptibility to systemic lupus erythematosus. (12415592)
2002
5
C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus. (10529130)
1999
6
C4 phenotypes in IgA nephropathy: disease progression associated with C4A deficiency but not with C4 isotype concentrations. (8706353)
1996
7
Clinical expression of systemic lupus erythematosus in patients with C4A deficiency. (8341140)
1993
8
Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression. (8473511)
1993
9
C4A deficiency and poor prognosis in patients with IgA nephropathy. (1889146)
1991
10
DR3 and nonDR3 associated complement component C4A deficiency in systemic lupus erythematosus. (2044237)
1991
11
Lack of gene deletion for complement C4A deficiency in Japanese patients with systemic lupus erythematosus. (1976809)
1990
12
Homozygous C4A deficiency in systemic lupus erythematosus: analysis of patients from a defined population. (2289315)
1990
13
Partial C4A deficiency is associated with susceptibility to systemic lupus erythematosus in black Americans. (3262348)
1988

Variations for C4a Deficiency

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Expression for genes affiliated with C4a Deficiency

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with C4a Deficiency

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Pathways for genes affiliated with C4a Deficiency

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to C4a Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3C4A, HLA-DRB1
29.3C4A, HLA-DRB1

Compounds for genes affiliated with C4a Deficiency

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GO Terms for genes affiliated with C4a Deficiency

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Products for genes affiliated with C4a Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for C4a Deficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet