MCID: CDS001
MIFTS: 70

Cadasil malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases, Eye diseases, Cardiovascular diseases categories

Aliases & Classifications for Cadasil

About this section
Sources:
45NIH Rare Diseases, 23Genetics Home Reference, 68Wikipedia, 65UMLS, 10Disease Ontology, 21GeneReviews, 46NINDS, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 22GeneTests, 24GTR, 42NCIt, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Cadasil:

Name: Cadasil 10 21 45 23 46 47 12 51 36
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 45 22 23 51 24
Familial Vascular Leukoencephalopathy 68 45 23 51 65
Multi-Infarct Dementia 68 46 65
Cadasil Syndrome 68 22 65
Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 45 23
Brain Small Vessel Disease with Hemorrhage 51 65
Dementia 68 65
Retinal Arteriolar Tortuosity - Infantile Hemiparesis - Autosomal Dominant Leukoencephalopathy 51
Cerebral Autosomal Dominant Ateriopathy with Subcortical Infarcts and Leukoencephalopathy 68
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarctsleukoencephalopathy 21
 
Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 68
Dementia, Hereditary Multi-Infarct Type 45
Hereditary Dementia, Multi-Infarct Type 23
Hereditary Multi-Infarct Dementia 51
Cerebrovascular Accident 65
Presenile Dementia 65
Lacunar Dementias 65
Lacunar Dementia 68
Stroke 68
Casil 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
cadasil:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (Europe),1-9/100000 (United Kingdom),1-9/100000 (Finland); Age of onset: Adult; Age of death: adult
familial vascular leukoencephalopathy:
Inheritance: Autosomal dominant


External Ids:

Disease Ontology10 DOID:13945
NCIt42 C84606
MeSH36 D046589
Orphanet51 136, 36383
ICD10 via Orphanet28 F01.1, I67.3
MESH via Orphanet37 D046589, C531642
UMLS via Orphanet66 C0751587, C2930808
ICD1027 F01.1

Summaries for Cadasil

About this section
NINDS:46 Is an inherited form of cerebrovascular disease that occurs when the thickening of blood vessel walls blocks the flow of blood to the brain. The disease primarily affects small blood vessels in the white matter of the brain. A mutation in the Notch3 gene alters the muscular walls in these small arteries. CADASIL is characterized by migraine headaches and multiple strokes progressing to dementia. Other symptoms include cognitive deterioration, seizures, vision problems, and psychiatric problems such as severe depression and changes in behavior and personality. Individuals may also be at higher risk of heart attack. Symptoms and disease onset vary widely, with signs typically appearing in the mid-30s. Some individuals may not show signs of the disease until later in life. CADASIL ? formerly known by several names, including hereditary multi-infarct dementia ? is one cause of vascular cognitive impairment (dementia caused by lack of blood to several areas of the brain). It is an autosomal dominant inheritance disorder, meaning that one parent carries and passes on the defective gene. Most individuals with CADASIL have a family history of the disorder. However, because the genetic test for CADASIL was not available before 2000, many cases were misdiagnosed as multiple sclerosis, Alzheimer's disease, or other neurodegenerative diseases.

MalaCards based summary: Cadasil, also known as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, is related to stroke, ischemic and alzheimer disease-4, and has symptoms including retinal vascular anomalies/retinal telangiectasia, transient amaurosis/acute visual trouble and facial pain/cephalalgia/migraine. An important gene associated with Cadasil is NOTCH3 (Notch 3), and among its related pathways are Dorso-ventral axis formation and Thyroid hormone signaling pathway. The drugs risperidone and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are hearing/vestibular/ear and normal.

NIH Rare Diseases:45 Cadasil (cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy) is an inherited disease of the blood vessels that occurs when the thickening of blood vessel walls blocks the flow of blood to the brain. the disease primarily affects the small blood vessels in the white matter of the brain. cadasil is characterized by migraine headaches and multiple strokes, which progresses to dementia. other symptoms include white matter lesions throughout the brain, cognitive deterioration, seizures, vision problems, and psychiatric problems such as severe depression and changes in behavior and personality. individuals may also be at higher risk of heart attack. symptoms and disease onset vary widely, with signs typically appearing in the mid-30s. some individuals may not show signs of the disease until later in life. cadasil is caused by a change (or mutation) in a gene called notch3 and is inherited in an autosomal dominant manner. last updated: 9/29/2015

Genetics Home Reference:23 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).

GeneReviews summary for cadasil

Related Diseases for Cadasil

About this section

Diseases related to Cadasil via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1772)
idRelated DiseaseScoreTop Affiliating Genes
1stroke, ischemic30.4APOE, MTHFR, NOTCH3
2alzheimer disease-430.1APOE, PSEN2
3amusia29.9MTHFR, PSEN2
4cerebrum cancer29.9APOE, COL4A1, MTHFR, NOTCH3
5demyelinating disease29.8APOE, NOTCH3, PSEN2
6migraine with or without aura 129.7MTHFR, NOTCH3, NOTCH4
7tetralogy of fallot29.7APOE, JAG1, MTHFR, NOTCH1
8duodenogastric reflux29.6JAG1, NOTCH1
9chorioretinitis29.4NOTCH1, NOTCH3, NOTCH4
10cerebritis11.0
11atrial fibrillation10.9
12aids dementia complex10.9
13spasticity10.9
14movement disease10.9
15peripheral vascular disease10.9
16patent foramen ovale10.8
17nervous system disease10.8
18mitral valve insufficiency10.8
19central nervous system disease10.8
20atrial fibrillation and stroke10.8
21transient cerebral ischemia10.8
22cerebral artery occlusion10.8
23factor xii deficiency10.8
24aphasia10.8
25neonatal stroke10.7
26familial atrial fibrillation10.7
27central post-stroke pain10.7
28atherosclerosis10.7
29lactic acidosis10.7
30brain injury10.7
31dysphagia10.7
32dementia10.7
33pick disease10.7
34carotid stenosis10.7
35hemorrhage, intracerebral10.7
36learning disability10.7
37neuromuscular disease10.7
38blood platelet disease10.7
39coronary heart disease 610.6
40speech and communication disorders10.6
41carotid artery disease10.6
42congenital heart disease10.6
43adrenal cortex disease10.6
44coronary heart disease 510.6
45acute myocardial infarction10.6
46carotid artery occlusion10.6
47coronary heart disease 310.6
48ischemic heart disease10.6
49hypertonia10.6
50hepatocellular carcinoma10.6

Graphical network of the top 20 diseases related to Cadasil:



Diseases related to cadasil

Symptoms for Cadasil

About this section

Symptoms:

 51 (show all 33)
  • retinal vascular anomalies/retinal telangiectasia
  • transient amaurosis/acute visual trouble
  • facial pain/cephalalgia/migraine
  • motor deficit/trouble
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • sensitive trouble/deficit
  • obnubilation/coma/lethargia/desorientation
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • psychic/psychomotor regression/dementia/intellectual decline
  • psychic/behavioural troubles
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • autosomal dominant inheritance
  • fever/chilling
  • mild visual loss/impaired visual acuity
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • cranial nerves palsy
  • transient cerebral ischemia/stroke
  • eeg anomalies
  • abnormal gait
  • hypertonia/spasticity/rigidity/stiffness
  • troubles of memory/amnesia/hypermnesia
  • hearing loss/hypoacusia/deafness
  • repeat respiratory infections
  • chronic arterial hypertension
  • arterial atheroma/precocious atherosclerosis/arteriosclerosis
  • varices/varicous veins/venous insufficiency
  • hypoglycemia
  • peripheral neuropathy
  • extrapyramidal syndrome
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intracranial/cerebral/meningeal hemorrhage
  • mucosal/cutaneous hemorrhage
  • early death/lethality

Drugs & Therapeutics for Cadasil

About this section

Drugs for Cadasil (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetaminophenapprovedPhase 4799103-90-21983
Synonyms:
4'-Hydroxyacetanilide
4'-hydroxyacetanilide
4-(Acetylamino)phenol
4-Acetamidophenol
4-Acetaminophenol
4-Hydroxyacetanilide
4-Hydroxyanilid kyseliny octove
4-acetamidophenol
7 Select Acetaminophen
7 Select Childrens Pain Relief
8 Hour Pain Relief
A-Per
A.F. Anacin
AC1Q1KYJ
AC1Q1KYK
APAP
Abenol
Abensanil
Abrol
Abrolet
Acamol
Accu-Tap
Acenol
Acephen
Acertol
Aceta Elixir
Aceta Tablets
Acetaco
Acetagesic
Acetalgin
Acetaminofen
Acetaminophen
Acetaminophen (red)
Acetaminophen - Apap 8 Hour
Acetaminophen - Apap Arthritis
Acetaminophen 8 Hour
Acetaminophen 8 hour
Acetaminophen EXTRA STRENGTH
Acetaminophen Easy Tabs Extra Strength
Acetaminophen Extended Release
Acetaminophen Extra Strength
Acetaminophen Junior
Acetaminophen Maximum Strength
Acetaminophen PAIN RELIEF
Acetaminophen Rapid Release
Acetaminophen Rapid Release Extra Strength
Acetaminophen Regular Strength
Acetaminophen Uniserts
Acetaminophen arthritis pain
Acetaminophen easy tabs
Acetaminophen extra strength
Acetaminophen for children
Acetaminophen infants
Acetaminophen pain reliever fever reducer
Acetaminophen pain reliever/fever reducer
Acetaminophen-apap 8 Hour
Acetaminophene
Acetamol
Acetavance
Acetofen
Actamin
Actamin Extra
Actamin Super
Actifed Plus
Actimol
Actimol Chewable Tablets
Actimol Children'S Suspension
Actimol Infants' Suspension
Actimol Junior Strength Caplets
Actron
Afebrin
Afebryl
Aferadol
Algesidal
Algina
Algomol
Algotropyl
Allay
Alpiny
Alpinyl
Alvedon
Amadil
Aminofen
Aminofen Max
Anacin
Anacin 3
Anacin Aspirin Free
Anacin-3
Anacin-3 Extra Strength
Anadin dla dzieci
Anaflon
Analter
Anapap
Andox
Anelix
Anexsia
Anexsia 10/660
Anexsia 5/325
Anexsia 7.5/325
Anexsia 7.5/650
Anhiba
Anoquan
Anti-Algos
Antidol
Anuphen
Apacet
Apacet Capsules
Apacet Elixir
Apacet Extra Strength Caplets
Apacet Extra Strength Tablets
Apacet Regular Strength Tablets
Apadon
Apamid
Apamide
Apap
Apap Extra Strength
Apap extra strength
Aphen
Apinophen EXTRA STRENGTH
Apitrelal
Apo-Acetaminophen
Arfen
Arthralgen
Arthritis 8 Hour
Arthritis Pain
Arthritis Pain Relief
Arthritis Pain Relief temporary minor
Arthritis Pain Reliever
Asetam
Asomal
Aspac
Aspirin Free
Aspirin Free Anacin Maximum Strength Caplets
Aspirin Free Anacin Maximum Strength Gel Caplets
Aspirin Free Anacin Maximum Strength Tablets
Aspirin Free Pain Relief
Aspirin-Free Anacin
Aspirin-Free Excedrin Caplets
Asplin
Atasol
Atasol Caplets
Atasol Drops
Atasol Forte Caplets
Atasol Forte Tablets
Atasol Oral Solution
Atasol Tablets
Atralidon
Aypanal
Babies R Us Childrens Pain Relief
Babies R Us Infants Pain Relief
Babies R Us Pain Relief
Babikan
Bacetamol
Bancap
Bancap Hc
Banesin
Bayer Select
Bayer Select Allergy-Sinus
Bayer Select Head Cold
Bayer Select Headache Pain
Bayer Select Maximum Strength Headache Pain Relief Formula
Bayer Select Menstrual Multi-Symptom
Bayer Select Sinus Pain Relief
Ben-u-ron
Benmyo
Bf-paradac
Bickie-mol
Biocetamol
Bucet
Butalbital
Butapap
CCRIS 3
CHEBI:46195
Cadafen
Calapol
Calmanticold
Calonal
Calpol
Capital
Capital with Codeine
Captin
Care One Arthritis Pain Relief
Care One Arthritis Pain Relief temporary minor
Care One Pain Relief
Care One Pain Relief 8 hour
Care One Pain Relief Childrens
Care One Pain Relief childrens
Care One Pain Relief extra strength
Care One Pain Relief infants
Careone Infants Pain Relief
Careone Pain Relief
Careone Pain Relief infants
Causalon
Cefalex
Cetadol
Cetafen
Cetafen Extra
Children Acetaminophen Grape Flavored Chewable
Children'S Acetaminophen Elixir Drops
Children'S Acetaminophen Oral Solution
Children'S Tylenol Chewable
Children's Pain Relief
Childrens Accudial Pain reliever/ Fever reducer
Childrens Acetaminophen
Childrens Acetaminophen Melts
Childrens Acetaminophen Oral Suspension Grape Flavor
Childrens Aspirin Free Rapid Tabs
Childrens Chewable Acetaminophen
Childrens Chewable Mapap
Childrens Chewable Pain Reliever
Childrens Fever Reducer
Childrens Mapap
Childrens Mapap Acetaminophen
Childrens Non Aspirin
Childrens Nortemp
Childrens Pain Relief
Childrens Pain Relief Acetaminophen
Childrens Pain Relief Bubblegum
Childrens Pain Relief Grape Flavor
Childrens Pain Relief ReadyInCase
Childrens Pain Reliever
Childrens Qpap
Childrens Silapap
Childrens Tylenol
Childrens non aspirin
Circle K Pain Reliever
Claradol Codeine
Clixodyne
Co-Gesic
Cod-Acamol Forte
Codabrol
Codalgin
Codapane
Codicet
Codisal
Codisal Forte
Codoliprane
Codral Pain Relief
Cofamol
Conacetol
Concentrated Aspirin Free infants
Conrx Extra Strength
Contac Cough & Sore Throat Formula
Contra-Schmerz P
Coricidin
Coricidin D
Coricidin Sinus
Cosutone
Counteract Childrens Pain Reliever
Counteract Pain
Croix Blanche
Cuponol
Curadon
Curpol
Custodial
D oliprane
Dafalgan
Dapa
Dapa X-S
Darocet
Darvocet
Darvocet-N 50
Datril
Datril Extra-Strength
Daygrip
Demilets
Deminofen
Democyl
Demogripal
Desfebre
Dg Health Arthritis Pain Relief
Dg Health Childrens Pain Relief
Dg Health Pain Relief
Dg Health Pain Relief Infants
Dg Health Pain Relief childrens
Dg Health Pain Reliever
Dg Health Pain Reliever extra strength
Dhamol
Dhc Plus
Dial-a-gesic
Dial-alpha-gesic
Dimindol
Direct Safety Aspirin Free
Direct Safety Extra Strength Aspirin Free
Dirox
Disprol
Dol-Stop
Dolcor
Dolefin
Dolegrippin
Dolene AP-65
Dolene Ap-65
Dolgesic
Doliprane
Dolko
Dolofin Infantil
Dolofugin
Doloreduct
Dolorfug
Dolorol Forte
Dolorstop
Dolotec
Dolprone
Dorocoff
Dover Aminophen
Dresan
Dristan Cold No Drowsiness
Dristancito
Drixoral Plus
Duaneo
Dularin
Duorol
Duracetamol
Duradyne Dhc
Durapan
Dye-free Childrens Acetaminophen Grape
Dymadon
Dymadon Co
Dymadon Forte
Dypap
Ecosetol
Ed Apap
Elixodyne
Empracet
Endecon
Enelfa
Eneril
Equaline Acetaminophen infants
Equaline Arthritis
Equaline Childrens Acetaminophen
Equaline Infants Acetaminophen
Equaline Pain Relief
Equaline Pain Relief childrens
Equaline Pain Relief concentrated
Equaline Pain Relief extra strength
Equaline Pain Relief infants
Equaline Pain Relief infants concentrated
Equate Acetaminophen
Equate Arthritis Pain
Equate Childrens Acetaminophen
Equate Pain Reliever Extra Strength
Esgic
Esgic-Plus
Eu-Med
Excedrin
Excedrin Caplets
Excedrin Extra Strength Caplets
Excipain
Exdol
Exdol Strong
Extra Strength Acetaminohpen Adult Rapid Burst Cherry
Extra Strength Acetaminophen
Extra Strength Aspirin Free Pain Relief
Extra Strength Headache Relief
Extra Strength Mapap
Extra Strength Non-aspirin
Extra Strength Non-aspirin Pain Reliever
Extra Strength Pain Relief
Extra Strength Pain Relief Acetaminophen
Extra Strength Pain Reliever
Extra Strength Qpap
Extra Strength Wal-nadol
Family Wellness Acetaminophen
Fanalgic
Farmadol
Febranine
Febrectal
Febrectol
Febrex
Febricet
Febridol
Febrilix
Febrin
Febrinol
Febro-Gesic
Febrolin
Femcet
Fendon
Fensum
Fepanil
Fever All
Fever Reducing childrens
Feverall
Feverall Adults
Feverall Children
Feverall Childrens
Feverall Infants
Feverall Jr. Strength
Feverall Junior
Feverall Junior Strength
Feverall Sprinkle Caps Junior Strength
Fevor
Finimal
Finiweh
Fioricet
Fluparmol
Formu Care Pain Relief
Fortalidon P
Fortolin
Freka-cetamol
Fulton Street Market Pain Relief extra strength
Gattaphen T
Gelocatil
Geluprane
Genapap
Genapap Children'S Elixir
Genapap Children'S Tablets
Genapap Extra Strength Caplets
Genapap Extra Strength Tablets
Genapap Regular Strength Tablets
Genebs
Genebs Extra Strength Caplets
Genebs Regular Strength Tablets
Genebs X-Tra
Geralgine-P
Gesteira
Good Neighbor Pharmacy 8 Hour Pain Relief
Good Neighbor Pharmacy Childrens Pain Relief
Good Neighbor Pharmacy Pain Relief
Good Neighbor Pharmacy Pain Relief Infants
Good Neighbor Pharmacy Pain Relief Rapid Release Extra Strength
Good Neighbor Pharmacy Pain Relief childrens
Good Neighbor Pharmacy Pain Relief extra strength
Good Neighbor Pharmacy Pain Relief infants
Good Neighbor Pharmacy Pain Relief regular strength
Good Sense Pain Relief
Good Sense Pain Relief 8 hour
Good Sense Pain Relief Extra Strength
Good Sense Pain Relief arthritis pain
Good Sense Pain Relief childrens
Good Sense Pain Relief extra strength
Good Sense Pain Relief infants concentrated
Good Sense Pain Reliefchildrens childrens
Green Guard Maximum Non-aspirin
Gripin Bebe
Grippostad
Gynospasmine
Health Mart Junior Rapid Melts
Health Mart Pain Relief
Health Sense Tactinal Extra Strength
Health Sense Tactinal Regular Strength
Healthy Accents Arthritis Pain Relief
Healthy Accents Pain Relief
Healthy Accents Pain Relief childrens
Healthy Accents Pain Relief extra strength
Healthy Accents Pain Relief infants
Healthy Mama SHAKE THAT ACHE
Hedex
Helon N
Help I Have A Headache
Henry Schein Acetaminophen
Homoolan
Hy-Phen
Hycomine Compound
Hydrocet
Ildamol
Inalgex
Infadrops
Infants Acetaminophen
Infants Acetaminophen Concentrated
Infants Mapap
Infants Mapap Pain Reliever /Fever Reducer
Infants Pain Relief
Infants Pain Relief Concentrated
Infants Pain Relief concentrated
Infants Pain Reliever
Infants Silapap
Infants Tylenol
Infants concentrated aspirin free
Infants' Feverall
Influbene N
Injectapap
Intensin
Janupap
Jin Gang
Junior Acetaminophen
Junior Aspirin Free Rapid Tabs
Junior Disprol
Junior Pain Relief
Junior Rapid Melts Grape
Junior Strength Acetaminophen
Junior Strength Pain Relief
Junior Strength Pain Reliever
Junior Strength Pain Reliever Grape
KBio1_000660
Kataprin
Kinder Finimal
Kirkland Signature Acetaminophen adult extra strength
Kirkland Signature Arthritis Pain
Kirkland Signature Infants Pain Relief
Kirkland Signature Non Aspirin Extra Strength
Kirkland Signature Pain Relief
Korum
Kratofin simplex
L024125
Labamol
Leader 8 Hour Pain Reliever
Leader Arthritis Pain
Leader Arthritis Pain Reliever
Leader Childrens Pain Reliever
Leader Extra Strength Pain Relief
Leader Pain Relief 8 HR
Leader Pain Relief childrens
Leader Pain Reliever
Leader Pain Reliever childrens
Leader Pain Reliever extra strength
Leader Pain Reliever infants
Leader Pain Reliever infants concentrated
Lekadol
Lemgrip
Lemsip
Lestemp
 
Lil Drug Store Pain Reliever Extra Strength
Liqiprine
Liquagesic
Liquigesic Co
Liquiprin
Liquiprin Children'S Elixir
Liquiprin Infants" Drops
Little Fevers By Little Remedies
Little Fevers Childrens Fever Pain Reliever
Little Fevers Infant Berry Fever/pain Reliever
Little Fevers Infant Grape Fever/pain Reliever
Lonarid
Lonarid Mono
Lorcet-Hd
Lortab
Lupocet
Lyteca
Lyteca Syrup
Magnidol
Malex N
Malgis
Malidens
Mapap
Mapap Arthritis Pain
Mapap Extra Strength
Mapap childrens
Mapap infants concentrated
Maxadol
Medi First Plus Non-aspirin
Medi First Plus Non-aspirin Extra Strength
Medi-first Non-aspirin
Medi-first Non-aspirin Extra Strength
Medicine Shoppe Arthritis Pain Reliever
Medigesic Plus
Medinol Paediatric
Medique Apap
Medique Apap Extra Strength
Medline Acetaminophen
Medocodene
Melabon Infantil
Members Mark Acetaminophen
Members Mark Arthritis Pain
Mexalen
Midol Maximum Strength
Midol PM Night Time Formula
Midol Regular Strength
Midol Teen Formula
Migraleve Yellow
Minafen
Minoset
Miralgin
Momentum
Mono Praecimed
Moore Medical Extra Strength Non Aspirin
Moore Medical Non Aspirin
Multin
N-(4-Hydroxyphenyl)acetamide
N-Acetyl-4-aminophenol
N-Acetyl-p-aminophenol
N-acetyl-p-aminophenol
NAPA
NCX 701
NEBS
NSC3991
Naldegesic
Napafen
Napap
Naprinol
Nealgyl
Nebs
Neo-Fepramol
NeoCitran
Neodol
Neodolito
Neopap
Neotrend
Neuridon
New Cortal for Children
NilnOcen
Nina
No-Febril
Nobedon
Nodolex
Non Aspirin Childrens
Non Aspirin Extra Strength
Non-aspirin
Noral
Norcet
Norco
Nortemp
O-Acetaminophenol
Ofirmev
Ohm 8 Hour Pain Reliever/fever Reducer
Oltyl
Oralgan
Oraphen-PD
Ortensan
Oxycet
Oxycocet
Oxycodone 2.5/Apap 500
Oxycodone 5/Apap 500
PCM Paracetamol Lichtenstein
Paceco
Pacemo
Pacemol
Pacet
Pacimol
Paedialgon
Paedol
Pain Relief
Pain Relief 8 Hr
Pain Relief 8 hour
Pain Relief Acetaminophen Extra Strength
Pain Relief Childrens
Pain Relief ES
Pain Relief Extra Strength
Pain Relief Infants
Pain Relief Regular Strength
Pain Relief childrens
Pain Relief concentrated infants
Pain Relief extra strength
Pain Relief infants
Pain Relief regular strength
Pain Reliever
Pain Reliever Extra Strength
Pain Reliever Extra Strength (Leader)
Pain Reliever Fever Reducer childrens
Pain Reliever Infants
Pain Reliever Rapid Release
Pain Reliever childrens
Pain Reliever extra strength
Pain Reliever infants
Painex
Paldesic
Pamol
Panacete
Panadeine
Panadeine Co
Panadiene
Panado-Co
Panado-Co Caplets
Panadol
Panadol Extra Strength
Panadol Junior Strength Caplets
Panadol Maximum Strength Caplets
Panadol Maximum Strength Tablets
Panale ve
Panaleve
Panamax
Panasorb
Panasorbe
Panets
Panex
Panodil
Panofen
Pantalgin
Papa-Deine
Papa-Deine #3
Papa-Deine #4
Para-Suppo
Para-Tabs
Paracemol
Paracenol
Paracet
Paracetamol
Paracetamol AL
Paracetamol Antipanin P
Paracetamol BC
Paracetamol Basics
Paracetamol DC
Paracetamol Dr. Schmidgall
Paracetamol Fecofar
Paracetamol Genericon
Paracetamol Hanseler
Paracetamol Harkley
Paracetamol Heumann
Paracetamol Hexal
Paracetamol Italfarmaco
Paracetamol Nycomed
Paracetamol PB
Paracetamol Raffo
Paracetamol Ratiopharm
Paracetamol Rosch
Paracetamol Saar
Paracetamol SmithKline Beecham
Paracetamol Stada
Paracetamol Winthrop
Paracetamol von ct
Paracetamole
Paracetamolo
Paracetamolum
Paracetanol
Paracetol
Paracin
Paracod
Paracodol
Parador
Paradrops
Parakapton
Parake
Paralen
Paralief
Paralink
Paralyoc
Paramol
Paramolan
Paranox
Parapan
Parasedol
Parasin
Paraspen
Parcetol
Parelan
Parmol
Parogal
Paroma
Pasolind
Pasolind N
Pe-Tam
Pediacare Childrens Fever Reducer Pain Reliever Cherry
Pediacare Childrens Fever Reducer Pain Reliever Dye Free
Pediacare Childrens Fever Reducer Pain Reliever Grape
Pediacare Infant Fever Pain Reliever
Pediacare Infants Fever Reducer Cherry
Pediacare Infants Fever Reducer Dye Free
Pediacare Infants Fever Reducer Grape
Pediacare Single Dose Fever Reducer
Pediapirin
Pediatrix
Pedric
Percocet
Percocet-5
Percocet-Demi
Percogesic with Codeine
Perdolan Mono
Perfalgan
Pharbetol
Pharbetol Regular strength
Phenaphen
Phenaphen Caplets
Phenaphen W/Codeine
Phendon
Phenipirin
Phogoglandin
Phrenilin
Phrenilin Forte
Physicianscare Non Aspirin Extra Strength
Pinex
Piramin
Pirinasol
Plicet
Plus Pharma Pain Reliever,Fever Reducer 325 mg
Pluspharma Extra Strength PAIN RELIEVER,FEVER REDUCER 500 mg
Polmofen
Powerful Pain Medicine
Predimol
Predualito
Preferred Plus Arthritis Pain
Preferred Plus Extra Strength Pain Relief
Premier Value Arthritis 8 Hour
Premier Value Arthritis Pain Reliever
Prestwick_13
Prodol
Prompt
Prontina
Propacet
Propacet 100
Proval #3
Puernol
Pulmofen
Pyregesic-C
Pyrigesic
Pyrinazine
Pyromed
Qpap Infants Drops
Quality Choice Extra Strength Pain Relief
Quiet World
Rapid Comfort Extra Strength Non Aspirin
Rapid Comfort Non Aspirin
Rapid Release Acetaminophen
Redutemp
Regular Strength Pain Relief
Regular Strength Pain Reliever
Regular Strength Qpap
Reliv
Remedol
Rexall Arthritis Pain
Rexall Pain Relief
Rhinex D-Lay Tablets
Ringl
Rivalgyl
Robigesic
Robitussin Night Relief
Rockamol Plus
Rounox
Roxicet
Roxicet 5/500
Roxilox
RubieMol
Rubophen
Rugby Acetaminophen
Rupemol
Rx Act Pain Relief
Rx Act Pain Relief 8 Hr
Rx Act Pain Relief Extra Strength
Rx Act Pain Relief Rapid Release
Rx Act Pain Relief extra strength
Rx Act Pain Relief infants
Rx Act Pain Relief regular strength
SK-Apap
SPBio_002836
Salzone
Sanicet
Sanicopyrine
Scanol
Scentalgyl
Scherzatabletten Rezeptur 534
Schmerzex
Sedalito
Sedapap
Semolacin
Servigesic
Seskamol
Setakop
Setamol
Setol
Severe Sinus Congestion
Shoprite Acetaminophen
Shoprite Arthritis Pain
Shoprite Childrens Acetaminophen
Shoprite Infants Acetaminophen
Shoprite Pain Relief
Sifenol
Simply Right Acetaminophen
Simply Right Arthritis Pain
Sinaspril
Sine-Off Sinus Medicine Caplets
Sinedol
Sinmol
Sinubid
Smart Sense Arthritis Pain Relief
Smart Sense Childrens Pain Relief
Smart Sense Infants Pain Relief
Smart Sense Pain Relief
Smart Sense Pain Relief 8 hour
Smart Sense Pain Relief Extra Strength
Smart Sense Pain Relief childrens
Smart Sense Pain Relief extra strength
Smart Sense Pain Relief infants
Snaplets-FR
Sohmed Extra Strength
Spalt N
Spalt fur die nacht
St Joseph Aspirin-Free
St Joseph Aspirin-Free for Children
St. Joseph Cold Tablets for Children
St. Joseph Fever Reducer
Stanback
Stopain
Sudafed Severe Cold Formula
Sudafed Sinus
Sunetheton
Sunmark 8 Hour Pain Relief
Sunmark Arthritis 8 Hour
Sunmark Arthritis Pain Relief
Sunmark Arthritis Pain Reliever
Sunmark Junior Rapid Melts
Sunmark Pain Relief Extra Strength
Sunmark Pain Reliever
Sunmark Pain Reliever Infants
Sunmark Pain Reliever extra strength
Sunmark Pain Reliever infants
Supac
Supadol mono
Supofen
Suppap
Suppap-120
Suppap-325
Suppap-650
Supramol-M
Swift Aypanal Extra
Synalgos-Dc-A
TYL
Tabalgin
Tachiprina
Talacen
Tapanol
Tapanol Extra Strength Caplets
Tapanol Extra Strength Tablets
Tapar
Tavist Allergy/Sinus/Headache
Tazamol
Temlo
Tempanal
Tempra
Tempra Caplets
Tempra Chewable Tablets
Tempra D.S
Tempra Drops
Tempra Syrup
Tencon
Termacet
Termalgin
Termalgine
Termofren
TheraFlu
Tibinide
Tibizide
Tiffy
Tisin
Tisiodrazida
Titralgan
Tizide
Tocris-1706
Topcare 8 Hour Pain Relief
Topcare Arthritis Pain
Topcare Arthritis Pain Relief
Topcare Arthritis Pain Relief Temporary Minor
Topcare Childrens Pain Relief
Topcare Fever Reducer
Topcare Infants Pain Relief
Topcare Pain Relief
Topcare Pain Relief Extra Strength
Topcare Pain Relief Infants
Topcare Pain Relief Rapid Release
Topcare Pain Relief extra strength
Topcare Pain Relief extra strength easy to swallow
Topco Arthritis 8 Hour
Toximer P
Tralgon
Treupel N
Treupel mon
Treuphadol
Triad
Triaminic Fever Reducer
Triaminic Infants Fever Reducer Pain Reliever - Bubblegum
Triaminic Infants Fever Reducer Pain Reliever - Grape
Triaminic Sore Throat Formula
Triaprin
Tricoton
Tussapap
Ty lenol
Tycolet
Tylenol
Tylenol (TN)
Tylenol Allergy Sinus
Tylenol Arthritis Extended Relief
Tylenol Arthritis Pain
Tylenol Caplets
Tylenol Children'S Chewable Tablets
Tylenol Children'S Elixir
Tylenol Children'S Suspension Liquid
Tylenol Cold Sore Throat Extra Strength
Tylenol Drops
Tylenol Elixir
Tylenol Extra Strength
Tylenol Extra Strength Adult Liquid Pain Reliever
Tylenol Extra Strength Caplets
Tylenol Extra Strength Gelcaps
Tylenol Extra Strength Tablets
Tylenol Gelcaps
Tylenol Infants Drops
Tylenol Infants" Suspension Drops
Tylenol Junior Strength Caplets
Tylenol Junior Strength Chewable Tablets
Tylenol Regular Strength
Tylenol Regular Strength Caplets
Tylenol Regular Strength Tablets
Tylenol SORE THROAT
Tylenol Tablets
Tylex
Tylex CD
Tylo Extra Strength
Tylol
Tylox
Tylox-325
Tymol
Ultracet
Upsanol
Utragin
Valadol
Valgesic
Valorin
Valorin Extra
Vanquish
Veralgina
Vermidon
Verpol
Viclor Richet
Vicodin
Vicodin Es
Vicodin Hp
Vips
Viruflu
Vivimed
Volpan
Welby Health Acetaminophen
Wygesic
Xl-dol
Zatinol
Zee Unaspirin ES
Zolben
alpha-Per
p-(Acetylamino)phenol
p-Acetamidophenol
p-Acetaminophenol
p-Acetylaminophenol
p-Hydroxyacetanilide
p-Hydroxyphenolacetamide
p-acetamidophenol
p-acetaminophenol
p-hydroxyacetanilide
p-hydroxyphenolacetamide
2
Buprenorphineapproved, illicit, investigationalPhase 436552485-79-740400, 644073
Synonyms:
(-)-Buprenorphine
(-)-buprenorphine
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-(methyloxy)-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
(5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol hydrochloride
(−)-buprenorphine
17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6-methoxy-6,14-endo-ethanomorphinan-3-ol
17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-7alpha-yl)-3,3-dimethyl-2-butanol
2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
2-[3-Cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol
21-(Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
21-Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine hydrochloride
21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
21-cyclopropyl-7alpha-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
52485-79-7
52485-79-7 (Parent)
53152-21-9
53152-21-9 (hydrochloride)
53187-13-6
55327-62-3
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-,
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (alphaS,5alpha,7alpha)- (9CI)
6029-M
64425-21-4
AC1L23NL
AC1L9B1M
AC1L9B1P
AC1LD8IH
AC1MHV55
BEMA LA
BEMA long acting analgesic
BEMA-buprenorphine
BUPRENORPHINE HYDROCHLORIDE
Buprel
Buprenex
Buprenex (TN)
Buprenophine
Buprenorfina
Buprenorfina [INN-Spanish]
Buprenorphine (JAN/INN)
Buprenorphine Depot
Buprenorphine Hcl
Buprenorphine Hydrochloride
Buprenorphine [INN:BAN]
Buprenorphine hydrochloride (JAN/USP)
Buprenorphine hydrochloride [USAN:JAN]
Buprenorphinum
Buprenorphinum [INN-Latin]
Buprex
Butrans
C08007
 
C29H41NO4
C29H41NO4.HCl
CHEBI:3216
CHEMBL1200401
CHEMBL1201894
CHEMBL47085
CID11969480
CID3033050
CID40400
CID441363
CID441364
CID5311033
CID6321408
CID644073
CL 112,302
CL 112302
CL-112302
D00836
D07132
DB00921
DEA No. 9064
EINECS 257-950-6
EINECS 258-396-8
ETI-311
Finibron
IX-1003
IX-1004
IX-1005
LS-67682
LS-67683
MR 56
MolPort-003-983-827
MolPort-004-285-844
MolPort-006-393-069
NIH 8805
NIH-8805
Norspan
PDSP2_000111
Probuphine
RX 6029-M
RX 6029M
RX-6029-M
Subutex
TSN-09
Temgesic
Temgesic (TN)
Transtec
UM 952
UM-952
UNII-40D3SCR4GZ
UNII-56W8MW3EN1
V-1003
V-1004
V-1005
[5alpha,7alpha(S)]-17-(Cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol
buprenorphine
3
DonepezilapprovedPhase 2260120014-06-43152
Synonyms:
( inverted exclamation markA)-E 2020
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
120014-06-4
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
AB1004836
AC-6969
AC1L1FAE
AKOS000277311
Aricept
Aricept ODT
C24H29NO3
CHEBI:53289
CHEMBL502
CID3152
D07869
DB00843
Domepezil
Donaz
Donaz (TN)
 
Donepezil
Donepezil (INN)
Donepezil Hydrochloride
Donepezil [INN:BAN]
Donepezil hydrochloride
Donepezilo
Donepezilum
Eranz
I06-0343
KBio2_002144
KBio2_004712
KBio2_007280
KBioSS_002144
LS-81819
MolPort-000-881-588
MolPort-003-847-014
NCGC00167537-01
Oprea1_188452
Spectrum5_001662
Spectrum_001664
TL8000531
UNII-8SSC91326P
4DabigatranPhase 2182
5Antithrombin IIIPhase 2259
6AntithrombinsPhase 2268
7serineNutraceuticalPhase 2420

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Pain Treatment on Depression in Patients With DementiaRecruitingNCT02267057Phase 4
2The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive ImpairmentCompletedNCT00103948Phase 2
3Safety Study of Dabigatran in CADASILRecruitingNCT01361763Phase 2
4Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)CompletedNCT01114815
5Impact of tDCS on Cerebral AutoregulationCompletedNCT01865604
6Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysisCompletedNCT01928212
7Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)RecruitingNCT02071784
8Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control StudiesRecruitingNCT02196532
9Generation of a Cellular Model of CADASIL From Skin FibroblastsEnrolling by invitationNCT02032225

Search NIH Clinical Center for Cadasil

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: CADASIL

Genetic Tests for Cadasil

About this section

Genetic tests related to Cadasil:

id Genetic test Affiliating Genes
1 Cadasil22 NOTCH3
2 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy24

Anatomical Context for Cadasil

About this section

MalaCards organs/tissues related to Cadasil:

33
Brain, Heart, Smooth muscle, Testes, Skin, Eye, Endothelial

Animal Models for Cadasil or affiliated genes

About this section

MGI Mouse Phenotypes related to Cadasil:

38 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.5APOE, JAG1, NOTCH1, NOTCH3
2MP:00028738.5EGF, JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2
3MP:00053828.4DCN, JAG1, LTBP1, NOTCH1, PSEN2
4MP:00053887.9APOE, DCN, NOTCH1, NOTCH3, PSEN2, RBPJ
5MP:00053867.8APOE, COL4A1, DCN, JAG1, NOTCH3, PSEN2
6MP:00053817.7APOE, DCN, EGF, JAG1, NOTCH1, PSEN2
7MP:00053807.7COL4A1, JAG1, LTBP1, NOTCH1, NOTCH3, NOTCH4
8MP:00053907.6APOE, DCN, JAG1, LTBP1, MTHFR, NOTCH1
9MP:00053697.5APOE, COL4A1, DCN, JAG1, LTBP1, NOTCH1
10MP:00053847.5APOE, COL4A1, DCN, JAG1, NOTCH1, NOTCH3
11MP:00053877.4APOE, DCN, EGF, NOTCH1, NOTCH3, PSEN2
12MP:00053857.3APOE, COL4A1, JAG1, LTBP1, NOTCH1, NOTCH3
13MP:00053897.1APOE, COL4A1, DCN, EGF, MTHFR, NOTCH3
14MP:00053797.1APOE, DCN, EGF, JAG1, NOTCH1, NOTCH3
15MP:00053677.1APOE, COL4A1, DCN, JAG1, LTBP1, NOTCH1
16MP:00053917.1APOE, COL4A1, DCN, EGF, JAG1, MTHFR
17MP:00053977.0APOE, COL4A1, DCN, JAG1, NOTCH1, NOTCH3
18MP:00107716.7APOE, DCN, EGF, JAG1, MTHFR, NOTCH1
19MP:00036316.5APOE, COL4A1, JAG1, LTBP1, MTHFR, NOTCH1
20MP:00107686.4APOE, COL4A1, DCN, JAG1, LTBP1, MTHFR
21MP:00053765.6APOE, COL4A1, DCN, JAG1, LTBP1, MTHFR
22MP:00053785.5APOE, COL4A1, DCN, EGF, JAG1, LTBP1

Publications for Cadasil

About this section

Articles related to Cadasil:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Response to Letter Regarding Article, "Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro". (25922512)
2015
2
Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke. (26305465)
2015
3
The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3. (25578324)
2015
4
Recurrent status epilepticus as the primary neurological manifestation of CADASIL: A case report. (25870789)
2015
5
Cerebral Microbleed Causing an Acute Stroke-like Episode in a CADASIL Patient. (25373821)
2014
6
Visual system involvement in CADASIL. (23635925)
2013
7
Diversity of stroke presentation in CADASIL: study from patients harboring the predominant NOTCH3 mutation R544C. (21852154)
2013
8
Parkinsonism is a late, not rare, feature of CADASIL: a study on Italian patients carrying the R1006C mutation. (23412372)
2013
9
Is the SHRSP [corrected] strain a suitable model of spontaneous CADASIL? (21809043)
2012
10
p.Arg332Cys mutation of NOTCH3 gene in two unrelated Japanese families with CADASIL. (22082899)
2011
11
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
12
CADASIL can mimic multiple sclerosis. (20666172)
2010
13
Genetically confirmed CADASIL in a pediatric patient. (21078731)
2010
14
Diagnostic criteria for CADASIL in the International Classification of Headache Disorders (ICHD-II): are they appropriate? (20224942)
2010
15
Adaptive metabolic changes in CADASIL white matter. (19690906)
2010
16
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): a patient from Sri Lanka. (19683925)
2009
17
MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study. (19139365)
2009
18
CADASIL presenting as status migrainosus and persisting aura without infarction. (18953486)
2009
19
The remarkably variable expressivity of CADASIL: report of a minimally symptomatic man at an advanced age. (19252787)
2009
20
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. (18296124)
2008
21
Is the increased expression of ubiquitin in CADASIL syndrome a manifestation of aberrant endocytosis in the vascular smooth muscle cells? (18313300)
2008
22
Psychiatric disturbances in CADASIL: a brief review. (18384453)
2008
23
CADASIL in Arabs: clinical and genetic findings. (17996090)
2007
24
Cerebellar arteriovenous malformation and vertebral artery aneurysm in a CADASIL patient. (16367901)
2006
25
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. (16391479)
2006
26
Postpartum psychiatric disturbances as an unrecognized onset of CADASIL. (16095483)
2005
27
CADASIL with NOTCH3 S180C presenting anticipation of onset age and hallucinations. (16111703)
2005
28
Peripheral neuropathy in CADASIL. (15827866)
2005
29
Intracerebral haemorrhage in CADASIL. (16227566)
2005
30
Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. (15569862)
2005
31
CADASIL: what component of the vessel wall is really a target for Notch 3 gene mutations? (15265274)
2004
32
CADASIL or CADVaSIL? (15068168)
2004
33
"CADASIL coma": an underdiagnosed acute encephalopathy. (12531961)
2003
34
Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. (12756589)
2003
35
Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosis. (12511775)
2003
36
Retinal findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil). (11274696)
2001
37
MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. (11245715)
2001
38
An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). (11136906)
2001
39
NOTCH3 mutation involving three cysteine residues in a family with typical CADASIL. (11706120)
2001
40
CADASIL: Notch signaling defect or protein accumulation problem? (10712425)
2000
41
Identification of a novel mutation C144F in the Notch3 gene in an Australian CADASIL pedigree. (11058919)
2000
42
Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking. (10926955)
2000
43
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) characteristics in Japan: variety of clinical features. (10969895)
2000
44
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy): diagnostic skin biopsy changes determined by electron microscopy. (11100036)
2000
45
Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (9974062)
1999
46
Cognitive alterations in non-demented CADASIL patients. (9548007)
1998
47
CADASIL: a review with proposed diagnostic criteria. (10210836)
1998
48
Differential diagnosis of a vascular leukoencephalopathy within a CADASIL family: use of skin biopsy electron microscopy study and direct genotypic screening. (9808243)
1998
49
SPECT study of a German CADASIL family: a phenotype with migraine and progressive dementia only. (9633716)
1998
50
Autosomal dominant migraine with MRI white-matter abnormalities mapping to the CADASIL locus. (7783868)
1995

Variations for Cadasil

About this section

Clinvar genetic disease variations for Cadasil:

5 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1NOTCH3NM_000435.2(NOTCH3): c.451C> G (p.Gln151Glu)single nucleotide variantPathogenicrs371491165GRCh37Chr 19, 15302999: 15302999
2COL4A1NM_001845.5(COL4A1): c.2085delC (p.Gly696Alafs)deletionPathogenicrs606231464GRCh38Chr 13, 110183003: 110183003
3COL4A1NM_001845.5(COL4A1): c.2194-1G> Asingle nucleotide variantPathogenicrs606231465GRCh38Chr 13, 110179422: 110179422
4COL4A1NM_001845.5(COL4A1): c.2263G> A (p.Gly755Arg)single nucleotide variantPathogenicrs672601346GRCh37Chr 13, 110831699: 110831699
5COL4A1NM_001845.5(COL4A1): c.2317G> C (p.Gly773Arg)single nucleotide variantPathogenicrs672601347GRCh37Chr 13, 110831645: 110831645
6COL4A1NM_001845.5(COL4A1): c.4881C> G (p.Asn1627Lys)single nucleotide variantPathogenicrs672601348GRCh38Chr 13, 110152381: 110152381
7COL4A1NM_001845.5(COL4A1): c.2122G> A (p.Gly708Arg)single nucleotide variantPathogenicrs672601349GRCh38Chr 13, 110181363: 110181363
8COL4A1NM_001845.5(COL4A1): c.1685G> A (p.Gly562Glu)single nucleotide variantPathogenicrs121912857GRCh37Chr 13, 110839528: 110839528
9COL4A1NM_001845.5(COL4A1): c.2159G> A (p.Gly720Asp)single nucleotide variantPathogenicrs113994108GRCh37Chr 13, 110833673: 110833673
10NOTCH3NM_000435.2(NOTCH3): c.457C> T (p.Arg153Cys)single nucleotide variantPathogenicrs797045014GRCh38Chr 19, 15192182: 15192182
11NOTCH3NM_000435.2(NOTCH3): c.3691C> T (p.Arg1231Cys)single nucleotide variantPathogenicrs201680145GRCh38Chr 19, 15179052: 15179052
12NOTCH3NM_000435.2(NOTCH3): c.1187C> G (p.Ser396Cys)single nucleotide variantPathogenicGRCh37Chr 19, 15300089: 15300089
13COL4A1NM_001845.5(COL4A1): c.1769G> A (p.Gly590Glu)single nucleotide variantPathogenicrs113994107GRCh37Chr 13, 110838860: 110838860
14NOTCH3NM_000435.2(NOTCH3): c.213G> T (p.Trp71Cys)single nucleotide variantPathogenicrs28937321GRCh37Chr 19, 15303315: 15303315
15NOTCH3NM_000435.2(NOTCH3): c.505C> T (p.Arg169Cys)single nucleotide variantPathogenicrs28933696GRCh37Chr 19, 15302945: 15302945
16NOTCH3NM_000435.2(NOTCH3): c.544C> T (p.Arg182Cys)single nucleotide variantPathogenicrs28933697GRCh37Chr 19, 15302906: 15302906
17NOTCH3NOTCH3, ALA-THRundetermined variantPathogenic
18NOTCH3NOTCH3, 45-BP DELdeletionPathogenic
19NOTCH3NM_000435.2(NOTCH3): c.1363T> C (p.Cys455Arg)single nucleotide variantPathogenicrs28933698GRCh37Chr 19, 15299815: 15299815
20NOTCH3NM_000435.2(NOTCH3): c.994C> T (p.Arg332Cys)single nucleotide variantPathogenicrs137852641GRCh37Chr 19, 15302277: 15302277
21NOTCH3NM_000435.2(NOTCH3): c.397C> T (p.Arg133Cys)single nucleotide variantPathogenicrs137852642GRCh37Chr 19, 15303053: 15303053
22NOTCH3NOTCH3, IVS15AS, G-T, -1single nucleotide variantPathogenic
23NOTCH3NM_000435.2(NOTCH3): c.1282T> A (p.Cys428Ser)single nucleotide variantPathogenicrs267606915GRCh37Chr 19, 15299896: 15299896

Expression for genes affiliated with Cadasil

About this section
Search GEO for disease gene expression data for Cadasil.

Pathways for genes affiliated with Cadasil

About this section

Pathways related to Cadasil according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2NOTCH1, NOTCH3, NOTCH4
29.2NOTCH1, NOTCH3, NOTCH4
3
Angiogenesis (CST)
Show member pathways
8.9NOTCH1, NOTCH3, NOTCH4
4
Show member pathways
8.9JAG1, NOTCH1, PSEN2, RBPJ
5
Show member pathways
8.9JAG1, NOTCH1, PSEN2, RBPJ
68.8NOTCH1, NOTCH3, NOTCH4, RBPJ
7
Show member pathways
8.8NOTCH1, NOTCH3, NOTCH4, RBPJ
8
Show member pathways
8.5EGF, JAG1, NOTCH1, PSEN2, RBPJ
9
Notch signaling pathway (Pathway Interaction Database)
Show member pathways
8.5EGF, JAG1, NOTCH1, PSEN2, RBPJ
108.4NOTCH1, NOTCH3, NOTCH4, PSEN2, RBPJ
118.3APOE, NOTCH1, NOTCH3, NOTCH4, PSEN2
12
Show member pathways
8.1JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2, RBPJ
138.1JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2, RBPJ
148.1JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2, RBPJ
15
Notch signaling pathway (KEGG)
Show member pathways
7.7JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2, RBPJ
16
Show member pathways
7.7DCN, EGF, JAG1, NOTCH1, PSEN2, RBPJ
17
Show member pathways
7.3COL4A1, EGF, LTBP1, NOTCH1, NOTCH3, NOTCH4
18
Show member pathways
7.1APOE, COL4A1, EGF, JAG1, NOTCH1, NOTCH3

GO Terms for genes affiliated with Cadasil

About this section

Cellular components related to Cadasil according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MAML1-RBP-Jkappa- ICN1 complexGO:000219310.3NOTCH1, RBPJ
2Golgi membraneGO:00001398.9NOTCH1, NOTCH3, NOTCH4, PSEN2
3extracellular matrixGO:00310128.3APOE, COL4A1, DCN, LTBP1
4extracellular regionGO:00055766.7APOE, COL4A1, DCN, EGF, JAG1, LTBP1

Biological processes related to Cadasil according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cholesterol effluxGO:009037010.4APOE, EGF
2distal tubule developmentGO:007201710.4JAG1, NOTCH1
3endocardium developmentGO:000315710.3NOTCH1, RBPJ
4endocardium morphogenesisGO:000316010.3NOTCH1, RBPJ
5auditory receptor cell fate commitmentGO:000991210.3NOTCH1, RBPJ
6interleukin-4 secretionGO:007260210.3NOTCH1, RBPJ
7epithelial to mesenchymal transition involved in endocardial cushion formationGO:000319810.3NOTCH1, RBPJ
8ventricular trabecula myocardium morphogenesisGO:000322210.3NOTCH1, RBPJ
9neuron fate commitmentGO:004866310.3NOTCH1, NOTCH3
10inflammatory response to antigenic stimulusGO:000243710.3NOTCH1, RBPJ
11pulmonary valve morphogenesisGO:000318410.3JAG1, NOTCH1
12positive regulation of Notch signaling pathwayGO:004574710.2JAG1, NOTCH1
13cardiac left ventricle morphogenesisGO:000321410.2NOTCH1, RBPJ
14regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationGO:000325610.2NOTCH1, RBPJ
15positive regulation of cardiac muscle cell proliferationGO:006004510.2NOTCH1, RBPJ
16negative regulation of stem cell differentiationGO:200073710.2JAG1, NOTCH1
17positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:006141910.2NOTCH1, RBPJ
18blood vessel remodelingGO:000197410.2JAG1, RBPJ
19endothelial cell differentiationGO:004544610.2JAG1, NOTCH4
20response to muramyl dipeptideGO:003249510.2JAG1, NOTCH1
21branching morphogenesis of an epithelial tubeGO:004875410.1EGF, NOTCH1
22neuronal stem cell population maintenanceGO:009715010.1JAG1, NOTCH1
23epithelial to mesenchymal transitionGO:000183710.1NOTCH1, RBPJ
24negative regulation of ossificationGO:003027910.1NOTCH1, RBPJ
25cell fate specificationGO:000170810.1NOTCH1, PSEN2
26cell fate determinationGO:000170910.0JAG1, NOTCH4
27positive regulation of BMP signaling pathwayGO:003051310.0NOTCH1, RBPJ
28cardiac septum morphogenesisGO:006041110.0JAG1, NOTCH1
29artery morphogenesisGO:00488449.9APOE, NOTCH3, RBPJ
30Notch signaling involved in heart developmentGO:00613149.9JAG1, NOTCH1, RBPJ
31regulation of Notch signaling pathwayGO:00085939.9NOTCH1, NOTCH4
32negative regulation of neuron differentiationGO:00456659.8JAG1, NOTCH1, NOTCH3
33positive regulation of transcription of Notch receptor targetGO:00072219.8NOTCH1, NOTCH4, RBPJ
34regulation of developmental processGO:00507939.8NOTCH1, NOTCH3, NOTCH4
35hemopoiesisGO:00300979.6JAG1, NOTCH4, RBPJ
36patterning of blood vesselsGO:00015699.6COL4A1, NOTCH4
37keratinocyte differentiationGO:00302169.5JAG1, NOTCH1, RBPJ
38forebrain developmentGO:00309009.5NOTCH1, NOTCH3, PSEN2
39regulation of cell proliferationGO:00421279.5JAG1, NOTCH1, RBPJ
40transcription initiation from RNA polymerase II promoterGO:00063679.3NOTCH1, NOTCH3, NOTCH4, RBPJ
41regulation of gene expressionGO:00104689.2APOE, NOTCH1, RBPJ
42negative regulation of cell differentiationGO:00455969.0JAG1, NOTCH1, NOTCH3, NOTCH4, RBPJ
43Notch receptor processingGO:00072209.0JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2
44multicellular organismal developmentGO:00072758.6JAG1, NOTCH1, NOTCH3, NOTCH4
45Notch signaling pathwayGO:00072198.5JAG1, NOTCH1, NOTCH3, NOTCH4, PSEN2, RBPJ

Molecular functions related to Cadasil according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051129.6JAG1, NOTCH1, NOTCH4
2calcium ion bindingGO:00055098.1EGF, JAG1, LTBP1, NOTCH1, NOTCH3, NOTCH4

Sources for Cadasil

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet