CASIL
MCID: CDS001
MIFTS: 55

Cadasil (CASIL) malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Cardiovascular diseases, Mental diseases

Aliases & Classifications for Cadasil

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Aliases & Descriptions for Cadasil:

Name: Cadasil 11 23 48 24 25 49 50 39 13
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 11 48 24 25
Familial Vascular Leukoencephalopathy 48 25 68
Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 48 25
Cadasil Syndrome 71 68
 
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarctsleukoencephalopathy 23
Dementia, Hereditary Multi-Infarct Type 48
Hereditary Dementia, Multi-Infarct Type 25
Hereditary Multi-Infarct Dementia 11
Casil 48

Characteristics:

GeneReviews:

23
Penetrance: penetrance of the disease is probably 100%, but expression varies in age of onset, severity of the clinical symptoms, and progression of the disease...


Classifications:



External Ids:

Disease Ontology11 DOID:13945
ICD1030 F01.1
MeSH39 D046589
NCIt45 C84606

Summaries for Cadasil

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NINDS:49  is an inherited form of cerebrovascular disease that occurs when the thickening of blood vessel walls blocks the flow of blood to the brain. The disease primarily affects small blood vessels in the white matter of the brain. A mutation in the Notch3 gene alters the muscular walls in these small arteries. CADASIL is characterized by migraine headaches and multiple strokes progressing to dementia. Other symptoms include cognitive deterioration, seizures, vision problems, and psychiatric problems such as severe depression and changes in behavior and personality. Individuals may also be at higher risk of heart attack. Symptoms and disease onset vary widely, with signs typically appearing in the mid-30s. Some individuals may not show signs of the disease until later in life. CADASIL — formerly known by several names, including hereditary multi-infarct dementia — is one cause of vascular cognitive impairment (dementia caused by lack of blood to several areas of the brain). It is an autosomal dominant inheritance disorder, meaning that one parent carries and passes on the defective gene. Most individuals with CADASIL have a family history of the disorder. However, because the genetic test for CADASIL was not available before 2000, many cases were misdiagnosed as multiple sclerosis, Alzheimer's disease, or other neurodegenerative diseases.

MalaCards based summary: Cadasil, also known as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, is related to cadasil 1 and cadasil 2, and has symptoms including sensorineural hearing impairment, visual impairment and depression. An important gene associated with Cadasil is NOTCH3 (Notch 3), and among its related pathways are Th2 Differentiation Pathway and Th17 cell differentiation. Affiliated tissues include brain, heart and testes, and related mouse phenotypes are embryo and digestive/alimentary.

Disease Ontology:11 An autosomal dominant cerebrovascular disorder characterized by recurrent subcortical ischemic stroke and cognitive impairment.

NIH Rare Diseases:48 Cadasil (cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy) is an inherited disease of the blood vessels that occurs when the thickening of blood vessel walls blocks the flow of blood to the brain. the disease primarily affects the small blood vessels in the white matter of the brain. cadasil is characterized by migraine headaches and multiple strokes, which progresses to dementia. other symptoms include white matter lesions throughout the brain, cognitive deterioration, seizures, vision problems, and psychiatric problems such as severe depression and changes in behavior and personality. individuals may also be at higher risk of heart attack. symptoms and disease onset vary widely, with signs typically appearing in the mid-30s. some individuals may not show signs of the disease until later in life. cadasil is caused by a change (or mutation) in a gene called notch3 and is inherited in an autosomal dominant manner. last updated: 9/29/2015

GeneReviews for NBK1500

Related Diseases for Cadasil

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Diseases in the Cadasil family:

Cadasil 1 Cadasil 2

Diseases related to Cadasil via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1cadasil 112.0
2cadasil 212.0
3cerebral arteriopathy with subcortical infarcts and leukoencephalopathy11.8
4brain small vessel disease with or without ocular anomalies11.0
5cerebritis10.6
6dementia10.2
7secondary lacrimal atrophy10.1JAG1, NOTCH3
8bone dysplasia azouz type10.1APOE, NOTCH3
9opiate dependence10.1EGF, JAG1
10pars planitis10.1APOE, MTHFR
11trigonocephaly with short stature and developmental delay10.1EGF, RBPJ
12combined oxidative phosphorylation deficiency 810.1APOE, PSEN2
13basal ganglia calcification10.0EGF, RBPJ
14dyserythropoietic anemia, congenital, type ii10.0APOE, EGF, JAG1
15retinitis10.0
16vascular dementia10.0
17encephalopathy10.0
18phosphoglycerate dehydrogenase deficiency10.0JAG1, NOTCH3, RBPJ
19contagious pustular dermatitis10.0APOE, MTHFR, NOTCH3
20cervix small cell carcinoma10.0APOE, MTHFR, NOTCH3
21meckel syndrome 1010.0APOE, PSEN2
22glaucoma 1, open angle, n10.0APOE, MTHFR
23budd-chiari syndrome10.0APOE, MTHFR, NOTCH3
24eumycotic mycetoma9.9APOE, NOTCH3, PSEN2
25interstitial emphysema9.9MTHFR, NOTCH3
26artery disease9.9
27peripheral artery disease9.8
28status epilepticus9.8
29hemiplegic migraine9.8
30familial hemiplegic migraine9.8
31headache9.8
32endotheliitis9.8
33bipolar disorder9.7
34migraine with aura9.7
35arteriovenous malformation9.7
36vascular disease9.7
37cerebrovascular disease9.7
38neuronitis9.7
39schizophrenia9.5
40myocardial infarction9.5
41multiple system atrophy9.5
42cerebral amyloid angiopathy9.5
43fabry disease9.5
44alopecia9.5
45cerebral hemorrhage9.5
46thrombocytopenia9.5
47balo concentric sclerosis9.5
48sensorineural hearing loss9.5
49hemiplegia9.5
50hypertensive retinopathy9.5

Graphical network of the top 20 diseases related to Cadasil:



Diseases related to cadasil

Symptoms & Phenotypes for Cadasil

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Human phenotypes related to Cadasil:

 64 (show all 32)
id Description HPO Frequency HPO Source Accession
1 sensorineural hearing impairment64 HP:0000407
2 visual impairment64 HP:0000505
3 depression64 HP:0000716
4 dementia64 HP:0000726
5 sensory neuropathy64 HP:0000763
6 hypertension64 HP:0000822
7 retinal arteriolar tortuosity64 HP:0001136
8 seizures64 HP:0001250
9 spasticity64 HP:0001257
10 coma64 HP:0001259
11 gait disturbance64 HP:0001288
12 confusion64 HP:0001289
13 subcutaneous hemorrhage64 HP:0001933
14 hypoglycemia64 HP:0001943
15 fever64 HP:0001945
16 abnormality of extrapyramidal motor function64 HP:0002071
17 migraine64 HP:0002076
18 cerebral cortical atrophy64 HP:0002120
19 hemiplegia64 HP:0002301
20 eeg abnormality64 HP:0002353
21 memory impairment64 HP:0002354
22 developmental regression64 HP:0002376
23 aphasia64 HP:0002381
24 varicose veins64 HP:0002619
25 atherosclerosis64 HP:0002621
26 cerebral ischemia64 HP:0002637
27 elevated serum creatine phosphokinase64 HP:0003236
28 recurrent pneumonia64 HP:0006532
29 cranial nerve paralysis64 HP:0006824
30 impaired pain sensation64 HP:0007328
31 subdural hemorrhage64 HP:0100309
32 amaurosis fugax64 HP:0100576

MGI Mouse Phenotypes related to Cadasil according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.4JAG1, LTBP1, NOTCH3, PSEN2, RBPJ
2MP:00053818.3APOE, EGF, JAG1, PSEN2, RBPJ
3MP:00053888.3APOE, NOTCH3, PSEN2, RBPJ, TIMP3
4MP:00053907.9APOE, JAG1, LTBP1, MTHFR, NOTCH3, RBPJ
5MP:00053697.8APOE, JAG1, LTBP1, NOTCH3, RBPJ, TIMP3
6MP:00053917.6APOE, EGF, JAG1, MTHFR, NOTCH3, PSEN2
7MP:00053797.4APOE, EGF, JAG1, NOTCH3, PSEN2, RBPJ
8MP:00053677.3APOE, JAG1, LTBP1, NOTCH3, PSEN2, RBPJ
9MP:00053877.2APOE, EGF, LTBP1, NOTCH3, PSEN2, RBPJ
10MP:00053857.1APOE, JAG1, LTBP1, NOTCH3, PSEN2, RBPJ
11MP:00036317.0APOE, JAG1, LTBP1, MTHFR, NOTCH3, PSEN2
12MP:00053766.7APOE, JAG1, LTBP1, MTHFR, NOTCH3, PSEN2
13MP:00107686.7APOE, JAG1, LTBP1, MTHFR, NOTCH3, PSEN2
14MP:00053976.7APOE, JAG1, LTBP1, NOTCH3, PSEN2, RBPJ
15MP:00053786.3APOE, EGF, JAG1, LTBP1, MTHFR, NOTCH3
16MP:00107716.0APOE, EGF, JAG1, LTBP1, MTHFR, NOTCH3

Drugs & Therapeutics for Cadasil

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Drugs for Cadasil (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Buprenorphineapproved, illicit, investigational, vet_approvedPhase 440952485-79-740400, 644073
Synonyms:
(-)-Buprenorphine
(-)-buprenorphine
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-(methyloxy)-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
(−)-buprenorphine
17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6-methoxy-6,14-endo-ethanomorphinan-3-ol
17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-7alpha-yl)-3,3-dimethyl-2-butanol
2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
2-[3-Cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol
21-(Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
21-cyclopropyl-7alpha-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
52485-79-7
53152-21-9 (hydrochloride)
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-,
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (alphaS,5alpha,7alpha)- (9CI)
6029-M
AC1L23NL
AC1L9B1M
AC1LD8IH
Buprel
Buprenex
Buprenophine
Buprenorfina
Buprenorfina [INN-Spanish]
 
Buprenorphine (JAN/INN)
Buprenorphine Hcl
Buprenorphine [INN:BAN]
Buprenorphinum
Buprenorphinum [INN-Latin]
C08007
C29H41NO4
CHEBI:3216
CHEMBL1201894
CHEMBL47085
CID40400
CID441363
CID5311033
CID6321408
CID644073
D07132
DB00921
DEA No. 9064
EINECS 257-950-6
LS-67682
MolPort-004-285-844
PDSP2_000111
Probuphine
RX 6029M
RX-6029-M
Subutex
Temgesic
Temgesic (TN)
UNII-40D3SCR4GZ
[5alpha,7alpha(S)]-17-(Cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol
buprenorphine
2
AcetaminophenapprovedPhase 41026103-90-21983
Synonyms:
4'-Hydroxyacetanilide
4'-hydroxyacetanilide
4-(Acetylamino)phenol
4-Acetamidophenol
4-Acetaminophenol
4-Hydroxyacetanilide
4-Hydroxyanilid kyseliny octove
4-acetamidophenol
A-Per
A.F. Anacin
AC1Q1KYJ
AC1Q1KYK
APAP
Abenol
Abensanil
Abrol
Abrolet
Acamol
Accu-Tap
Acenol
Acephen
Acertol
Aceta Elixir
Aceta Tablets
Acetaco
Acetagesic
Acetalgin
Acetaminofen
Acetaminophen
Acetaminophen Uniserts
Acetamol
Acetavance
Acetofen
Actamin
Actamin Extra
Actamin Super
Actifed Plus
Actimol
Actimol Chewable Tablets
Actimol Children'S Suspension
Actimol Infants' Suspension
Actimol Junior Strength Caplets
Actron
Afebrin
Afebryl
Aferadol
Algesidal
Algina
Algomol
Algotropyl
Allay
Alpiny
Alpinyl
Alvedon
Amadil
Aminofen
Aminofen Max
Anacin
Anacin 3
Anacin-3
Anacin-3 Extra Strength
Anadin dla dzieci
Anaflon
Analter
Anapap
Andox
Anelix
Anexsia
Anexsia 10/660
Anexsia 5/325
Anexsia 7.5/325
Anexsia 7.5/650
Anhiba
Anoquan
Anti-Algos
Antidol
Anuphen
Apacet
Apacet Capsules
Apacet Elixir
Apacet Extra Strength Caplets
Apacet Extra Strength Tablets
Apacet Regular Strength Tablets
Apadon
Apamid
Apamide
Apitrelal
Apo-Acetaminophen
Arfen
Arthralgen
Asetam
Asomal
Aspac
Aspirin Free Anacin Maximum Strength Caplets
Aspirin Free Anacin Maximum Strength Gel Caplets
Aspirin Free Anacin Maximum Strength Tablets
Aspirin-Free Anacin
Aspirin-Free Excedrin Caplets
Asplin
Atasol
Atasol Caplets
Atasol Drops
Atasol Forte Caplets
Atasol Forte Tablets
Atasol Oral Solution
Atasol Tablets
Atralidon
Babikan
Bacetamol
Bancap
Bancap Hc
Banesin
Bayer Select
Bayer Select Allergy-Sinus
Bayer Select Head Cold
Bayer Select Headache Pain
Bayer Select Maximum Strength Headache Pain Relief Formula
Bayer Select Menstrual Multi-Symptom
Bayer Select Sinus Pain Relief
Ben-u-ron
Benmyo
Bickie-mol
Biocetamol
Bucet
Butalbital
Butapap
CCRIS 3
CHEBI:46195
Cadafen
Calapol
Calmanticold
Calonal
Calpol
Capital
Capital with Codeine
Captin
Causalon
Cefalex
Cetadol
Children'S Acetaminophen Elixir Drops
Children'S Acetaminophen Oral Solution
Children'S Tylenol Chewable
Claradol Codeine
Clixodyne
Co-Gesic
Cod-Acamol Forte
Codabrol
Codalgin
Codapane
Codicet
Codisal
Codisal Forte
Codoliprane
Codral Pain Relief
Cofamol
Conacetol
Contac Cough & Sore Throat Formula
Contra-Schmerz P
Coricidin
Coricidin D
Coricidin Sinus
Cosutone
Croix Blanche
Cuponol
Curadon
Curpol
Custodial
D oliprane
Dafalgan
Dapa
Dapa X-S
Darocet
Darvocet
Darvocet-N 50
Datril
Datril Extra-Strength
Daygrip
Demilets
Deminofen
Democyl
Demogripal
Desfebre
Dhamol
Dhc Plus
Dial-a-gesic
Dial-alpha-gesic
Dimindol
Dirox
Disprol
Dol-Stop
Dolcor
Dolefin
Dolegrippin
Dolene AP-65
Dolene Ap-65
Dolgesic
Doliprane
Dolko
Dolofugin
Doloreduct
Dolorfug
Dolorol Forte
Dolorstop
Dolotec
Dolprone
Dorocoff
Dresan
Dristan Cold No Drowsiness
Dristancito
Drixoral Plus
Duaneo
Dularin
Duorol
Duracetamol
Duradyne Dhc
Durapan
Dymadon
Dymadon Co
Dymadon Forte
Dypap
Ecosetol
Elixodyne
Empracet
Endecon
Enelfa
Eneril
Esgic
Esgic-Plus
Eu-Med
Excedrin
Excedrin Caplets
Excedrin Extra Strength Caplets
Excipain
Exdol
Exdol Strong
Fanalgic
Farmadol
Febranine
Febrectal
Febrectol
Febrex
Febricet
Febridol
Febrilix
Febrin
Febrinol
Febro-Gesic
Febrolin
Femcet
Fendon
Fensum
Fepanil
Fever All
Feverall
Feverall Junior Strength
Feverall Sprinkle Caps Junior Strength
Fevor
Finimal
Finiweh
Fioricet
Fluparmol
Fortalidon P
Freka-cetamol
Gattaphen T
Gelocatil
Geluprane
Genapap
Genapap Children'S Elixir
Genapap Children'S Tablets
Genapap Extra Strength Caplets
Genapap Extra Strength Tablets
Genapap Regular Strength Tablets
Genebs
Genebs Extra Strength Caplets
Genebs Regular Strength Tablets
Genebs X-Tra
Geralgine-P
Gripin Bebe
Grippostad
Gynospasmine
Hedex
Helon N
Homoolan
Hy-Phen
Hycomine Compound
Hydrocet
Ildamol
Inalgex
Infadrops
Infants' Feverall
Influbene N
Injectapap
Intensin
Janupap
Jin Gang
Junior Disprol
KBio1_000660
Kataprin
Kinder Finimal
Korum
Kratofin simplex
L024125
Labamol
Lekadol
Lemgrip
Lemsip
Lestemp
Liqiprine
Liquagesic
Liquigesic Co
Liquiprin
Liquiprin Children'S Elixir
Liquiprin Infants" Drops
Lonarid
Lonarid Mono
Lorcet-Hd
Lortab
Lupocet
Lyteca
Lyteca Syrup
Magnidol
Malex N
Malgis
Malidens
Maxadol
Medigesic Plus
Medinol Paediatric
Medocodene
Melabon Infantil
Mexalen
Midol Maximum Strength
Midol PM Night Time Formula
Midol Regular Strength
Midol Teen Formula
Migraleve Yellow
Minafen
Minoset
Miralgin
Momentum
Mono Praecimed
 
Multin
N-(4-Hydroxyphenyl)acetamide
N-Acetyl-4-aminophenol
N-Acetyl-p-aminophenol
N-acetyl-p-aminophenol
NAPA
NCX 701
NEBS
NSC3991
Naldegesic
Napafen
Napap
Naprinol
Nealgyl
Nebs
Neo-Fepramol
NeoCitran
Neodol
Neodolito
Neopap
Neotrend
Neuridon
New Cortal for Children
NilnOcen
Nina
No-Febril
Nobedon
Nodolex
Noral
Norcet
Norco
O-Acetaminophenol
Ofirmev
Oltyl
Oralgan
Oraphen-PD
Ortensan
Oxycet
Oxycocet
Oxycodone 2.5/Apap 500
Oxycodone 5/Apap 500
PCM Paracetamol Lichtenstein
Paceco
Pacemo
Pacemol
Pacet
Pacimol
Paedialgon
Paedol
Painex
Paldesic
Pamol
Panacete
Panadeine
Panadeine Co
Panadiene
Panado-Co
Panado-Co Caplets
Panadol
Panadol Extra Strength
Panadol Junior Strength Caplets
Panadol Maximum Strength Caplets
Panadol Maximum Strength Tablets
Panale ve
Panaleve
Panamax
Panasorb
Panasorbe
Panets
Panex
Panodil
Panofen
Pantalgin
Papa-Deine
Papa-Deine #3
Papa-Deine #4
Para-Suppo
Para-Tabs
Paracemol
Paracenol
Paracet
Paracetamol
Paracetamol AL
Paracetamol Antipanin P
Paracetamol BC
Paracetamol Basics
Paracetamol DC
Paracetamol Dr. Schmidgall
Paracetamol Fecofar
Paracetamol Genericon
Paracetamol Hanseler
Paracetamol Harkley
Paracetamol Heumann
Paracetamol Hexal
Paracetamol Italfarmaco
Paracetamol Nycomed
Paracetamol PB
Paracetamol Raffo
Paracetamol Ratiopharm
Paracetamol Rosch
Paracetamol Saar
Paracetamol SmithKline Beecham
Paracetamol Stada
Paracetamol Winthrop
Paracetamol von ct
Paracetamole
Paracetamolo
Paracetamolum
Paracetanol
Paracetol
Paracin
Paracod
Paracodol
Paracétamol
Parador
Paradrops
Parakapton
Parake
Paralen
Paralief
Paralink
Paralyoc
Paramol
Paramolan
Paranox
Parapan
Parasedol
Parasin
Paraspen
Parcetol
Parelan
Parmol
Parogal
Paroma
Pasolind
Pasolind N
Pe-Tam
Pediapirin
Pediatrix
Pedric
Percocet
Percocet-5
Percocet-Demi
Percogesic with Codeine
Perdolan Mono
Perfalgan
Phenaphen
Phenaphen Caplets
Phenaphen W/Codeine
Phendon
Phenipirin
Phogoglandin
Phrenilin
Phrenilin Forte
Pinex
Piramin
Pirinasol
Plicet
Polmofen
Predimol
Predualito
Prestwick_13
Prodol
Prompt
Prontina
Propacet
Propacet 100
Proval #3
Puernol
Pulmofen
Pyregesic-C
Pyrigesic
Pyrinazine
Pyromed
Quiet World
Redutemp
Reliv
Remedol
Rhinex D-Lay Tablets
Rivalgyl
Robigesic
Robitussin Night Relief
Rockamol Plus
Rounox
Roxicet
Roxicet 5/500
Roxilox
RubieMol
Rubophen
Rupemol
SK-Apap
SPBio_002836
Salzone
Sanicet
Sanicopyrine
Scanol
Scentalgyl
Scherzatabletten Rezeptur 534
Schmerzex
Sedalito
Sedapap
Semolacin
Servigesic
Seskamol
Setakop
Setamol
Setol
Sifenol
Sinaspril
Sine-Off Sinus Medicine Caplets
Sinedol
Sinmol
Sinubid
Snaplets-FR
Spalt N
Spalt fur die nacht
St Joseph Aspirin-Free
St Joseph Aspirin-Free for Children
St. Joseph Cold Tablets for Children
St. Joseph Fever Reducer
Stanback
Stopain
Sudafed Severe Cold Formula
Sudafed Sinus
Sunetheton
Supac
Supadol mono
Supofen
Suppap
Suppap-120
Suppap-325
Suppap-650
Supramol-M
Synalgos-Dc-A
TYL
Tabalgin
Tachiprina
Talacen
Tapanol
Tapanol Extra Strength Caplets
Tapanol Extra Strength Tablets
Tapar
Tavist Allergy/Sinus/Headache
Tazamol
Temlo
Tempanal
Tempra
Tempra Caplets
Tempra Chewable Tablets
Tempra D.S
Tempra Drops
Tempra Syrup
Tencon
Termacet
Termalgin
Termalgine
Termofren
TheraFlu
Tibinide
Tibizide
Tiffy
Tisin
Tisiodrazida
Titralgan
Tizide
Tocris-1706
Toximer P
Tralgon
Treupel N
Treupel mon
Treuphadol
Triad
Triaminic Sore Throat Formula
Triaprin
Tricoton
Tussapap
Ty lenol
Tycolet
Tylenol
Tylenol (TN)
Tylenol Allergy Sinus
Tylenol Arthritis Extended Relief
Tylenol Caplets
Tylenol Children'S Chewable Tablets
Tylenol Children'S Elixir
Tylenol Children'S Suspension Liquid
Tylenol Drops
Tylenol Elixir
Tylenol Extra Strength Adult Liquid Pain Reliever
Tylenol Extra Strength Caplets
Tylenol Extra Strength Gelcaps
Tylenol Extra Strength Tablets
Tylenol Gelcaps
Tylenol Infants Drops
Tylenol Infants" Suspension Drops
Tylenol Junior Strength Caplets
Tylenol Junior Strength Chewable Tablets
Tylenol Regular Strength Caplets
Tylenol Regular Strength Tablets
Tylenol Tablets
Tylex
Tylex CD
Tylol
Tylox
Tylox-325
Tymol
Ultracet
Upsanol
Utragin
Valadol
Valgesic
Valorin
Valorin Extra
Vanquish
Veralgina
Vermidon
Verpol
Viclor Richet
Vicodin
Vicodin Es
Vicodin Hp
Vips
Viruflu
Vivimed
Volpan
Wygesic
Zatinol
Zolben
acetaminofén
acétaminophène
alpha-Per
p-(Acetylamino)phenol
p-Acetamidophenol
p-Acetaminophenol
p-Acetylaminophenol
p-Hydroxyacetanilide
p-Hydroxyphenolacetamide
p-acetamidophenol
p-acetaminophenol
p-hydroxy-acetanilid
p-hydroxyacetanilide
p-hydroxyphenolacetamide
3Central Nervous System DepressantsPhase 413403
4NarcoticsPhase 43646
5Narcotic AntagonistsPhase 4935
6Peripheral Nervous System AgentsPhase 4, Phase 323689
7AntipyreticsPhase 41605
8Analgesics, Non-NarcoticPhase 46501
9AnalgesicsPhase 411733
10Analgesics, OpioidPhase 43238
11
AmlodipineapprovedPhase 349688150-42-92162
Synonyms:
()-Amlodipine
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (.+/-.)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
88150-42-9
88150-47-4 (maleate (1:1))
AC-4535
AC1L1D26
AC1Q32ZS
AMLODIPINE BASE
AMVAZ
Ambap88150-42-9
Amlocard
Amlodipine
Amlodipine (INN)
Amlodipine Benzenesulfonate
Amlodipine Besilate
Amlodipine Besylate
Amlodipine Free Base
Amlodipine [INN:BAN]
Amlodipine besilate
Amlodipine besylate
Amlodipine free base
Amlodipino
Amlodipino [Spanish]
Amlodipinum
Amlodipinum [Latin]
Amlodis
Amlopres
Amlor
 
Amvaz
BIDD:GT0810
BRD-A22032524-074-02-4
BRD-A22032524-074-03-2
BSPBio_002727
C06825
CHEBI:2668
CHEMBL1491
CID2162
CPD000469198
Coroval
D07450
DB00381
HMS2052N03
HMS2089H07
I14-0798
Intervask
Istin
KBio3_001947
KBioGR_001643
LS-131183
Lipinox
Lotrel
MLS001401409
MolPort-001-792-963
NCGC00165957-01
NCGC00165957-02
NCGC00165957-03
Norvasc
Norvasc (TN)
Pelmec
R,S)-Amlodipine
Racemic Amlodipine
SAM001246705
SMR000469198
SPBio_000351
Spectrum2_000486
Spectrum3_001004
Spectrum4_001132
Spectrum5_001550
UK-4834011
UNII-1J444QC288
amlodipine
12
AtenololapprovedPhase 310429122-68-72249
Synonyms:
( inverted question mark)-Atenolol
(+-)-4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetamide
(+-)-Atenolol
(+/-)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
(1)-2-(4-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
(?)-Atenolol
1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol
2-(4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl)acetamid
2-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide
2-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide
2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
29122-68-7
4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide
4-[2 -Hydroxy-3 -(isopropylamino)-propoxy]phenylacetamide
4-[2'-Hydroxy-3'-(isopropylamino)propoxy]phenylacetamide
60966-51-0
A 7655
A7655_SIGMA
AC-11142
AC1L1D99
AC1Q1QBX
AKOS005111050
ARONIS23884
Acetamide,2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)
Aircrit
Alinor
Altol
Anselol
Antipressan
Apo-Atenolol
Atcardil
Atecard
Atehexal
Atenblock
Atendol
Atenet
Ateni
Atenil
Atenol
Atenol 1A Pharma
Atenol 1A pharma
Atenol AL
Atenol Acis
Atenol Atid
Atenol CT
Atenol Cophar
Atenol Fecofar
Atenol GNR
Atenol Gador
Atenol Genericon
Atenol Heumann
Atenol MSD
Atenol NM Pharma
Atenol Nordic
Atenol PB
Atenol Quesada
Atenol Stada
Atenol Tika
Atenol Trom
Atenol Von CT
Atenol acis
Atenol ct
Atenol von ct
Atenol-Mepha
Atenol-Ratiopharm
Atenol-Wolff
Atenol-ratiopharm
Atenolin
Atenolol (JAN/USP)
Atenolol (JP15/USP/INN)
Atenolol [USAN:BAN:INN:JAN]
Atenolol [USAN:INN:BAN:JAN]
Atenololum
Atenololum [INN-Latin]
Atenomel
Atereal
Aterol
BB_SC-1519
BIM-0050109.0001
BRD-A20239487-001-02-5
BRN 2739235
BSPBio_002915
Betablok
Betacard
Betasyn
Betatop GE
Betatop Ge
Blocotenol
Blokium
CCRIS 4196
CHEBI:2904
CHEMBL24
CID2249
CPD000036768
Cardaxen
Cardiopress
Corotenol
Cuxanorm
D001262
D00235
DB00335
DivK1c_000057
Duraatenolol
Duratenol
 
EINECS 249-451-7
EINECS 262-544-7
EU-0100121
Evitocor
Farnormin
Felo-Bits
HMS1569L13
HMS1921H09
HMS2090I19
HMS2092D19
HMS500C19
HSDB 6526
Hipres
Hypoten
I01-3572
ICI 66,082
ICI 66082
ICI-66082
ICI66082
IDI1_000057
Ibinolo
InChI=1/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
Internolol
Jenatenol
Juvental
KBio1_000057
KBio2_001844
KBio2_004412
KBio2_006980
KBio3_002415
KBioGR_000790
KBioSS_001844
L000116
LS-28557
LS-9707
Lo-Ten
Lo-ten
Lopac0_000121
Loten
Lotenal
MLS000069622
MLS001066372
MLS001074163
MLS001304038
MolPort-001-792-717
Myocord
NCGC00015007-07
NCGC00015007-13
NCGC00024566-03
NCGC00024566-04
NCGC00024566-05
NCGC00024566-06
NCGC00024566-07
NINDS_000057
Neatenol
Normalol
Normiten
Noten
Oprea1_448775
Oraday
Ormidol
Panapres
Plenacor
Premorine
Prenolol
Prenormine
Prinorm
SAM002564193
SMR000036768
SPBio_001482
SPECTRUM1501127
STK528649
Scheinpharm Atenol
Seles Beta
Seles beta
Selobloc
Serten
Servitenol
Spectrum2_001411
Spectrum3_001448
Spectrum4_000435
Spectrum5_001509
Spectrum_001364
Stermin
Tenidon
Teno-Basan
Teno-basan
Tenobloc
Tenoblock
Tenolol
Tenoprin
Tenoretic
Tenormin
Tenormin (TN)
Tenormine
Tenormine [French]
Tensimin
Tensotin
Tredol
UNII-50VV3VW0TI
Unibloc
Uniloc
Vascoten
Vericordin
Wesipin
Xaten
atenolol
benzeneacetamide, 4-[2'-hydroxy-3
duratenol
13
LosartanapprovedPhase 3286114798-26-43961
Synonyms:
(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
114798-26-4
124750-99-8 (mono-potassium salt)
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol
2-N-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole
AC1L1H3Q
BIDD:GT0286
BRD-K76205745-001-02-5
BSPBio_002695
C07072
C22H23ClN6O
CHEBI:6541
CHEMBL191
CID3961
CL23623
Cozaar
D08146
DB00678
DUP 89
DuP 89
DuP-753
HMS1922J13
HMS2093E22
Hyzaar
I14-9710
Jsp001094
KBio2_002193
 
KBio2_004761
KBio2_007329
KBio3_001915
KBioGR_001611
KBioSS_002193
L000351
LOSARTAN POTASSIUM
LS-78746
Lacidipine
Lortaan
Losartan
Losartan (INN)
Losartan Potassium
Losartan [INN:BAN]
Losartan monopotassium salt
Losartic
Losartic (TN)
MK-954
MK954
MolPort-003-666-553
NCGC00095125-01
NCGC00095125-02
NCGC00095125-03
Oprea1_644635
SPBio_001893
SPECTRUM1504268
Spectrum2_001677
Spectrum3_000998
Spectrum4_001126
Spectrum5_001466
Spectrum_001713
UNII-JMS50MPO89
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
losartan
losartan potassium
14Neurotransmitter AgentsPhase 3, Phase 218340
15Vasodilator AgentsPhase 33543
16Autonomic AgentsPhase 310150
17calcium channel blockersPhase 31985
18Calcium, DietaryPhase 35713
19SympatholyticsPhase 3580
20Antihypertensive AgentsPhase 34207
21Adrenergic AntagonistsPhase 31573
22Adrenergic AgentsPhase 35352
23Anti-Arrhythmia AgentsPhase 33093
24Adrenergic beta-AntagonistsPhase 31193
25Adrenergic beta-1 Receptor AntagonistsPhase 3364
26AngiotensinogenPhase 31177
27
Angiotensin IIPhase 3117868521-88-0, 11128-99-765143, 172198
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II
28Angiotensin Receptor AntagonistsPhase 31191
29Angiotensin II Type 1 Receptor BlockersPhase 31091
30
DonepezilapprovedPhase 2286120014-06-43152
Synonyms:
( inverted exclamation markA)-E 2020
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
120014-06-4
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
AB1004836
AC-6969
AC1L1FAE
AKOS000277311
Aricept
Aricept ODT
C24H29NO3
CHEBI:53289
CHEMBL502
CID3152
D07869
DB00843
Domepezil
Donaz
Donaz (TN)
 
Donepezil
Donepezil (INN)
Donepezil [INN:BAN]
Donepezil hydrochloride
Donepezilo
Donepezilum
Eranz
I06-0343
KBio2_002144
KBio2_004712
KBio2_007280
KBioSS_002144
LS-81819
MolPort-000-881-588
MolPort-003-847-014
NCGC00167537-01
Oprea1_188452
Spectrum5_001662
Spectrum_001664
TL8000531
UNII-8SSC91326P
31
protease inhibitorsPhase 25471
Synonyms:
 
protease inhibitors
32HIV Protease InhibitorsPhase 25470
33Serine Proteinase InhibitorsPhase 2878
34Antithrombin IIIPhase 2690
35AntithrombinsPhase 2697
36AnticoagulantsPhase 22623
37DabigatranPhase 2237
38Nootropic AgentsPhase 2716
39Cholinergic AgentsPhase 23992
40Cholinesterase InhibitorsPhase 2592
41serineNutraceuticalPhase 2954

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Efficacy of Pain Treatment on Depression in Patients With DementiaCompletedNCT02267057Phase 4
2Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular FunctionNot yet recruitingNCT03082014Phase 3
3Safety Study of Dabigatran in CADASILUnknown statusNCT01361763Phase 2
4The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive ImpairmentCompletedNCT00103948Phase 2
5Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control StudiesUnknown statusNCT02196532
6Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)CompletedNCT01114815
7The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage?CompletedNCT02837354
8Impact of tDCS on Cerebral AutoregulationCompletedNCT01865604
9Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysisCompletedNCT01928212
10CADASIL Disease DiscoveryRecruitingNCT02821780
11Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)RecruitingNCT02071784
12Generation of a Cellular Model of CADASIL From Skin FibroblastsEnrolling by invitationNCT02032225

Search NIH Clinical Center for Cadasil


Cochrane evidence based reviews: cadasil

Genetic Tests for Cadasil

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Genetic tests related to Cadasil:

id Genetic test Affiliating Genes
1 Cadasil24 NOTCH3

Anatomical Context for Cadasil

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MalaCards organs/tissues related to Cadasil:

36
Brain, Heart, Testes, Skin, Smooth muscle, Endothelial, Cortex

Publications for Cadasil

About this section

Articles related to Cadasil:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
CADASIL mimicking multiple sclerosis: The importance of clinical and MRI red flags. (27773545)
2017
2
Genotype-phenotype correlations of cysteine replacement in CADASIL. (27890607)
2017
3
Managing Depression in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL): A Case Report. (27828708)
2016
4
Novel mutation of the NOTCH3 gene in a Polish family with CADASIL. (27375140)
2016
5
CADASIL and multiple sclerosis: A case report of prolonged misdiagnosis. (27712110)
2016
6
Multifocal Cerebral and Bilateral Middle Cerebellar Peduncle Infarctions in CADASIL. (26956688)
2016
7
A Novel mutation of the Notch3 gene in a Chinese Pedigree with CADASIL. (27781952)
2016
8
Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice. (26648042)
2016
9
CADASIL presenting with spontaneous intracerebral hemorrhage: report of a case and description of the first family in Northern Greece. (27895449)
2016
10
Archetypal NOTCH3 mutations frequent in public exome: implications for CADASIL. (27844030)
2016
11
The comparisons of phenotype and genotype between CADASIL and CADASIL-like patients and population-specific evaluation of CADASIL scale in China. (27206574)
2016
12
Diffusion Tensor Imaging to Map Brain Microstructural Changes in CADASIL. (27357066)
2016
13
CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. (27309730)
2016
14
Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept. (26912635)
2016
15
CADASIL Presenting as Acute Bilateral Multiple Subcortical Infarcts without a Characteristic Temporal Pole or Any External Capsule Lesions. (27725551)
2016
16
Phenotypic comparison of individuals with homozygous or heterozygous mutation of NOTCH3 in a large CADASIL family. (27423596)
2016
17
Recurrent transient global amnesia as presenting symptoms of CADASIL. (27830070)
2016
18
Cutaneous sensory and autonomic denervation in CADASIL. (26873958)
2016
19
A Japanese CADASIL kindred with a novel two-base NOTCH3 mutation. (27079553)
2016
20
Blood Biomarkers in a Mouse Model of CADASIL. (27174004)
2016
21
CADASIL, CARASIL, CARASAL: The linguistic subtleties of cerebral small vessel disease. (27664986)
2016
22
Targeted next generation sequencing identifies novel NOTCH3 gene mutations in CADASIL diagnostics patients. (27881154)
2016
23
Study of a CADASIL family with migraine as the presenting symptom]. (27455010)
2016
24
Prediction of 3-year clinical course in CADASIL. (27694265)
2016
25
Parkinsonism in a pair of monozygotic CADASIL twins sharing the R1006C mutation: a transcranial sonography study. (26850715)
2016
26
CADASIL: Imaging Characteristics and Clinical Correlation. (27591799)
2016
27
Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL, and healthy brains. (27143427)
2016
28
The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation. (26715087)
2015
29
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) - literature review apropos an autopsy case. (26619111)
2015
30
Are granular osmiophilic material deposits an epiphenomenon in CADASIL? (26216120)
2015
31
CADASIL with a Novel NOTCH3 Mutation (Cys478Tyr). (25595846)
2015
32
Cerebral hyperperfusion on arterial spin labeling MRI during CADASIL migrainous encephalopathy. (26567267)
2015
33
Genotypic and phenotypic spectrum of CADASIL in Japan: the experience at a referral center in Kumamoto University from 1997 to 2014. (25980907)
2015
34
The genetic spectrum and the evaluation of CADASIL screening scale in Chinese patients with NOTCH3 mutations. (25982499)
2015
35
NOTCH3 variants in patients with subcortical vascular cognitive impairment: a comparison with typical CADASIL patients. (26002683)
2015
36
Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke. (26305465)
2015
37
APOE and AGT in the Finnish p.Arg133Cys CADASIL population. (25819272)
2015
38
Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis. (25555543)
2015
39
Characterization of CADASIL among the Han Chinese in Taiwan: Distinct Genotypic and Phenotypic Profiles. (26308724)
2015
40
Recurrent status epilepticus as the primary neurological manifestation of CADASIL: A case report. (25870789)
2015
41
CADASIL with Multiorgan Involvement: a Complete Autopsy Examination Report. (26138243)
2015
42
Correction: Clinical Significance of Cerebral Microbleeds Locations in CADASIL with R544C NOTCH3 Mutation. (25856100)
2015
43
Correction: R54C Mutation of NOTCH3 Gene in the First Rungus Family with CADASIL. (26368811)
2015
44
Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. (26167496)
2015
45
The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3. (25578324)
2015
46
Response to Letter Regarding Article, "Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro". (25922512)
2015
47
Clinical significance of cerebral microbleeds locations in CADASIL with R544C NOTCH3 mutation. (25692567)
2015
48
Letter by Rutten et al Regarding Article, "Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro". (25922511)
2015
49
Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations. (26563570)
2015
50
Longitudinally extensive transverse myelopathy in a patient with CADASIL. (26352503)
2015

Variations for Cadasil

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Expression for genes affiliated with Cadasil

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Search GEO for disease gene expression data for Cadasil.

Pathways for genes affiliated with Cadasil

About this section

Pathways related to Cadasil according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.7JAG1, RBPJ
2
Show member pathways
9.4JAG1, NOTCH3, RBPJ
39.4APOE, PSEN2
4
Show member pathways
9.3JAG1, NOTCH3, TIMP3
5
Show member pathways
9.3EGF, LTBP1
69.1NOTCH3, PSEN2, RBPJ
7
Show member pathways
9.1JAG1, PSEN2, RBPJ
8
Show member pathways
9.1JAG1, PSEN2, RBPJ
99.1APOE, NOTCH3, PSEN2
10
Show member pathways
8.8JAG1, NOTCH3, PSEN2, RBPJ
118.8JAG1, NOTCH3, PSEN2, RBPJ
12
Show member pathways
8.8JAG1, NOTCH3, PSEN2, RBPJ
138.8JAG1, NOTCH3, PSEN2, RBPJ
148.8EGF, LTBP1, TIMP3
15
Show member pathways
7.4EGF, LTBP1, NOTCH3, PSEN2, RBPJ, TIMP3

GO Terms for genes affiliated with Cadasil

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Cellular components related to Cadasil according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.4APOE, LTBP1, TIMP3
2extracellular regionGO:00055767.6APOE, EGF, JAG1, LTBP1, NOTCH3, TIMP3

Biological processes related to Cadasil according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron differentiationGO:004566510.4JAG1, NOTCH3
2blood vessel remodelingGO:000197410.3JAG1, RBPJ
3Notch signaling involved in heart developmentGO:006131410.3JAG1, RBPJ
4negative regulation of cell differentiationGO:004559610.0JAG1, NOTCH3, RBPJ
5angiogenesisGO:000152510.0EGF, JAG1, RBPJ
6artery morphogenesisGO:00488449.9APOE, NOTCH3, RBPJ
7Notch receptor processingGO:00072209.7JAG1, NOTCH3, PSEN2
8Notch signaling pathwayGO:00072198.8JAG1, NOTCH3, PSEN2, RBPJ

Molecular functions related to Cadasil according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00055098.6EGF, JAG1, LTBP1, NOTCH3

Sources for Cadasil

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet