Calcinosis malady

Wikipedia: Calcinosis is the formation of calcium deposits in any soft tissue.⁴⁴ more...

MalaCards: Calcinosis, also known as pathologically calcified structure, is related to familial tumoral calcinosis and hyperphosphatemic familial tumoral calcinosis. An important gene associated with Calcinosis is FGF23 (fibroblast growth factor 23), and among its related pathways are Graft-versus-host disease and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The compounds methylmethacrylate and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Disease Ontology: A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.⁶

Aliases & Descriptions:

calcinosis 6 7 8 32 43 pathologically calcified structure 6 pathologic calcification 6

calcinosis (disorder) 6 pathology processes 43

Diseases related to calcinosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 395)

id	Related Disease	Score	Top Affiliating Genes
1	familial tumoral calcinosis	34.8	GTDC2, FGF23, GALNT3
2	hyperphosphatemic familial tumoral calcinosis	34.5	FGF23, GALNT3
3	normophosphatemic familial tumoral calcinosis	32.6	RGL2, SAMD9, TNF, EGR1, GALNT3
4	tumoral calcinosis, hyperphosphatemic	31.3	KL, FGF23
5	crest syndrome	31.0	CENPB, FBN1, TGFB3
6	hyperostosis	29.9	KL, FGF23, ALPL, PTH, SPP1, GALNT3
7	pseudohypoparathyroidism	27.5	GNAS, CALCA, PTH
8	hyperphosphatemia	26.8	KL, MGP, FGF23, ALPL, ALPP, ALPPL2
9	arthropathy	26.4	KITLG, LMNA, ZMPSTE24, FGF23, ANKH, ALPL
10	dermatomyositis	25.1	PIK3C2A, MGP, MEPE, FBN1, GPT, CALCA
11	psoriasis	24.4	KIR3DL2, KITLG, GPT, CALCA, HLA-DQA1, HLA-DQB1
12	systemic lupus erythematosus	24.3	PIK3C2A, RGL2, CENPB, FBN1, ALPP, CALCA
13	lupus erythematosus	24.3	PIK3C2A, RGL2, CENPB, FBN1, ALPP, CALCA
14	cholesterol	24.0	PIK3C2A, KL, KITLG, LMNA, ZMPSTE24, CEACAM3
15	dermatitis	23.5	PIK3C2A, KIR3DL2, KITLG, FBN1, GPT, CALCA
16	hereditary hypophosphatemic rickets	13.7	FGF23, MEPE, GALNT3
17	tight skin contracture syndrome, lethal	13.7	LMNA, ZMPSTE24
18	hypervitaminosis d	13.6	KL, FGF23, PTH
19	osteofibrous dysplasia	13.6	GNAS, SPP1, SPARC
20	craniosynostosis, syndromic	13.6	FBN1, ENPP1, ANKH
21	restrictive dermopathy	13.6	LMNA, ZMPSTE24
22	arterial calcification of infancy	13.5	FGF23, ENPP1, PHEX
23	mongolian spot	13.5	SAMD9L, MGP, FBN1
24	pseudogout	13.5	ENPP1, ANKH
25	ankylosing spondylitis	13.5	FBN1, ANKH, TNF, PTH
26	dentin dysplasia, type ii	13.5	SPP1, DSPP
27	hypophosphatemic rickets, autosomal dominant	13.5	FGF23, MEPE, PHEX
28	limb-girdle muscular dystrophy	13.4	PIK3C2A, LMNA, GTDC2
29	aortic valve stenosis	13.4	MGP, FBN1, TNF, AHSG
30	dentin dysplasia	13.4	MEPE, SPP1, DSPP
31	ankylosis	13.4	ENPP1, ANKH, SPP1, DSPP
32	clear cell adenoma	13.4	ALPP, PTH
33	humoral hypercalcemia of malignancy	13.4	FGF23, CASR, TNF
34	hypophosphatasia	13.4	ALPL, ALPP
35	mccune albright syndrome	13.3	FGF23, ALPP, GNAS, SPARC
36	malaria	13.3	GNAS, TNF, ABO
37	progressive osseous heteroplasia	13.3	ENPP1, ALPP, GNAS, SPARC
38	calciphylaxis	13.3	PIK3C2A, CASR, SPP1
39	x-linked hypophosphatemia	13.3	FGF23, PHEX
40	dental pulp calcification	13.3	FBN1, DSPP
41	myxoma	13.3	KITLG, SAMD9, GNAS, TNF
42	protein s deficiency	13.3	PIK3C2A, LMNA, MGP, GNAS, SPP1
43	systemic scleroderma	13.3	KITLG, CENPB, FBN1, APITD1
44	common bile duct disease	13.3	ALPL, ALPP, ALPPL2
45	nephropathia epidemica	13.3	PIK3C2A, HLA-DRB1, TNF
46	dentinogenesis imperfecta	13.3	MEPE, SPP1, DSPP
47	ossification of posterior longitudinal ligament of spine	13.3	ENPP1, ALPP, PTH
48	bile duct disease	13.2	ENPP1, GPT
49	coronary artery anomaly	13.2	PIK3C2A, LMNA, MGP, FBN1, ENPP1, SPARC
50	hypoparathyroidism, autosomal dominant	13.2	CASR, PTH

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to calcinosis:

²²

MGI Mouse Phenotypes related to calcinosis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	GALNT3, PTH, GNAS, CENPB, KL
2	liver/biliary system phenotype	MP:0005370	9.9	EGR1, ZMPSTE24
3	respiratory system phenotype	MP:0005388	9.5	CALCA, ALPL, ANKH, FBN1, FGF23, MGP
4	other phenotype	MP:0005395	9.2	PHEX, SPP1, CASR, ALPL, ANKH, ENPP1
5	renal/urinary system phenotype	MP:0005367	9.1	PHEX, CASR, GNAS, FBN1, FGF23, MGP
6	adipose tissue phenotype	MP:0005375	9.1	PHEX, TNF, GNAS, ALPL, ENPP1, FBN1
7	hearing/vestibular/ear phenotype	MP:0005377	8.9	KITLG, LMNA, ENPP1, ANKH, GNAS, CALCA
8	reproductive system phenotype	MP:0005389	8.6	GALNT3, SLC6A3, SPP1, TNF, ALPP, ALPL
9	limbs/digits/tail phenotype	MP:0005371	8.5	GNAS, PTH, PHEX, TGFB3, GALNT3, ALPL
10	hematopoietic system phenotype	MP:0005397	8.4	SPARC, PTH, HLA-DQB1, HLA-DQA1, CASR, ALPL
11	craniofacial phenotype	MP:0005382	8.3	TNF, PTH, PHEX, DSPP, TGFB3, GNAS
12	digestive/alimentary phenotype	MP:0005381	7.7	TGFB3, PHEX, TNF, HLA-DQB1, CASR, ALPL
13	integument phenotype	MP:0010771	7.6	CASR, CALCA, TNF, SPP1, EGR1, SLC6A3
14	immune system phenotype	MP:0005387	7.5	GNAS, HLA-DQA1, HLA-DQB1, TNF, PTH, SPARC
15	muscle phenotype	MP:0005369	7.2	CASR, HLA-DQB1, TNF, SPP1, AHSG, SLC6A3
16	skeleton phenotype	MP:0005390	7.1	KITLG, CALCA, PTH, SPP1, SPARC, PHEX
17	cardiovascular system phenotype	MP:0005385	7.1	CALCA, HLA-DQB1, TNF, PTH, SPP1, EGR1
18	growth/size phenotype	MP:0005378	6.8	ALPP, GNAS, PTH, SPP1, PHEX, EGR1
19	nervous system phenotype	MP:0003631	6.4	TNF, SPP1, PHEX, EGR1, TGFB3, SLC6A3
20	cellular phenotype	MP:0005384	6.3	HLA-DQB1, TNF, SPP1, PHEX, EGR1, TGFB3
21	behavior/neurological phenotype	MP:0005386	6.3	HLA-DQB1, TNF, SPP1, SPARC, PHEX, EGR1
22	mortality/aging	MP:0010768	6.1	GNAS, CASR, HLA-DQB1, PTH, PHEX, EGR1
23	homeostasis/metabolism phenotype	MP:0005376	5.5	HLA-DQB1, TNF, SPP1, SPARC, PHEX, EGR1

Articles related to calcinosis:

(show all 47)

id	Title	Authors	Year	Affiliating Genes
1	Functional characterization of SAMD9, a protein defic ient in normophosphatemic familial tumoral calcinosis. (21160498)	Hershkovitz D.... Sprecher E.	2011	EGR1, RGL2, SAMD9
2	Familial tumoral calcinosis and hyperostosis-hyperpho sphataemia syndrome are different manifestations of the same disease: novel mis sense mutations in GALNT3. (19830424)	Joseph L.... Delaney D.	2010	GALNT3
3	Familial tumoral calcinosis: from characterization of a rare phenotype to the pathogenesis of ectopic calcification. (19865099)	Sprecher E.	2010	GALNT3
4	Clinical variability of familial tumoral calcinosis c aused by novel GALNT3 mutations. (20358599)	Ichikawa S.... Econs M.J.	2010	GALNT3, FGF23
5	A novel recessive mutation of fibroblast growth factor-23 in tumoral calcinosis. (19411468)	Masi L.... Brandi M.L.	2009	GALNT3, FGF23
6	Familial tumoral calcinosis: a forty-year follow-up on one family. (19255228)	Carmichael K.D.... Evans E.B.	2009	GALNT3
7	Familial tumoral calcinosis and the role of O-glycosy lation in the maintenance of phosphate homeostasis. (19013236)	Chefetz I.... Sprecher E.	2009	GALNT3
8	Defective O-glycosylation due to a novel homozygous S 129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis. (19837926)	Bergwitz C.... JA1ppner H.	2009	FGF23
9	Dopamine transporter SPECT/CT and perfusion brain SPE CT imaging in idiopathic basal ganglia calcinosis. (19542944)	Paschali A.... Vassilakos P.	2009	SLC6A3
10	Familial tumoral calcinosis caused by a novel FGF23 mutation: response to induction of tubular renal acidosis with acetazolamide and the non-calcium phosphate binder sevelamer. (19188744)	Lammoglia J.J.... Mericq V.	2009	KL, GALNT3, FGF23
11	GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. (18976705)	Chefetz I.... Sprecher E.	2009	GALNT3
12	Autoantibodies to a 140-kd protein in juvenile dermat omyositis are associated with calcinosis. (19479859)	Gunawardena H.... McHugh N.J.	2009	HLA-DQA1, HLA-DQB1, HLA-DRB1
13	A case of familial tumoral calcinosis/hyperostosis-hy perphosphatemia syndrome due to a compound heterozygous mutation in GALNT3 demo nstrating new phenotypic features. (18982401)	Dumitrescu C.E.... Collins M.T.	2009	GALNT3
14	Calcinosis in juvenile dermatomyositis: a possible role for the vitamin K-dependent protein matrix Gla protein. (18234711)	van Summeren M.J.... Schurgers L.J.	2008	MGP
15	Risk factors associated with calcinosis of juvenile d ermatomyositis. (18185899)	Sallum A.M.... Silva C.A.	2008	GPT
16	Tumoral calcinosis due to GALNT3 C.516-2A >T mutation in a black African family. (18618993)	Laleye A.... Arveiler B.	2008	GALNT3, FGF23
17	Molecular genetic and biochemical analyses of FGF23 mutations in familial tumoral calcinosis. (18682534)	Garringer H.J.... White K.E.	2008	FGF23
18	Normophosphatemic familial tumoral calcinosis is caused by deleterious mutations in SAMD9, encoding a TNF-alpha responsive protein. (18094730)	Chefetz I.... Sprecher E.	2008	TNF, SAMD9
19	Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis. (18448482)	Marhaug G.... Brogan P.A.	2008	SPP1
20	Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. (17898038)	Mo L.... Wu X.R.	2007	SPP1
21	Two novel GALNT3 mutations in familial tumoral calcinosis. (17853462)	Garringer H.J.... White K.E.	2007	GALNT3
22	A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. (17710231)	Ichikawa S.... Econs M.J.	2007	KL, KITLG, GALNT3
23	Tumoral calcinosis (17507846)	Douira L.... Mansouri F.	2007	GALNT3, FGF23
24	SAMD9 mutation in normophosphatemic familial tumoral calcinosis (17507861)	Dereure O.	2007	SAMD9
25	Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis. (17351710)	Barbieri A.M.... Beck-Peccoz P.	2007	GALNT3
26	Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene. (16940445)	Ichikawa S.... Econs M.J.	2006	GALNT3
27	A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis. (16960814)	Topaz O.... Sprecher E.	2006	GALNT3, SAMD9
28	A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. (16278265)	Van Esch H.... Garg A.	2006	LMNA, ZMPSTE24
29	The role of mutant UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 in regulating serum intact fibroblast growth factor 23 and matrix extracellular phosphoglycoprotein in heritable tumoral calcinosis. (16868048)	Garringer H.J.... White K.E.	2006	GALNT3, MEPE
30	Familial tumoral calcinosis and testicular microlithiasis associated with a new mutation of GALNT3 in a white family. (16567474)	Campagnoli M.F.... Ramenghi U.	2006	GALNT3
31	Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis. (17050587)	Davies C.A.... Herrick A.L.	2006	SPARC, MGP
32	Familial tumoral calcinosis with hyperphosphatemia is heterogeneous and associated with mutations in GALNT3 or FGF-23 (16733465)	Dereure O.	2006	GALNT3, FGF23
33	Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. (16638743)	Kato K.... Clausen H.	2006	GALNT3, FGF23
34	Hyperphosphatemic familial tumoral calcinosis caused by a mutation in GALNT3 in a European kindred. (16528452)	Specktor P.... Sprecher E.	2006	GALNT3
35	A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis. (16030159)	Araya K.... Fujita T.	2005	FGF23
36	A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: evidence that the disorder is autosomal recessive. (15687324)	Ichikawa S.... Econs M.J.	2005	GALNT3
37	Early manifestation of calcinosis cutis in pseudohypoparathyroidism type Ia associated with a novel mutation in the GNAS gene. (15817905)	Riepe F.G.... Partsch C.-J.	2005	GNAS
38	Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed. (15961556)	Larsson T.... White K.E.	2005	FGF23
39	A novel recessive mutation in fibroblast growth facto r-23 causes familial tumoral calcinosis. (15687325)	Larsson T.... White K.E.	2005	FGF23
40	An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. (15590700)	Benet-Pages A.... Lorenz-Depiereux B.	2005	GALNT3, FGF23
41	Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders. (15599692)	Frishberg Y.... Sprecher E.	2005	GALNT3, GTDC2
42	Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. (15133511)	Topaz O.... Sprecher E.	2004	GALNT3
43	Resolution of massive uremic tumoral calcinosis with daily nocturnal home hemodialysis. (12613005)	Kim S.J.... Pierratos A.	2003	PTH
44	Immunohistochemical expression of transforming growth factor beta3 in calcinosis in a patient with systemic sclerosis and CREST syndrome. (11069531)	Kawakami T.... Saito R.	2000	TGFB3
45	Uremic tumoral calcinosis: preliminary observations s uggesting an association with aberrant vitamin D homeostasis. (1962658)	Quarles L.D.... Lyles K.W.	1991	CALCA
46	A case of idiopathic vulvar calcinosis: the first in Japan. (1800536)	Fukaya Y.... Ueda H.	1991	CEACAM3
47	Dental lesions in tumoral calcinosis. (2066872)	Burkes E.J.... Hanker J.	1991	DSPP

Genes related to calcinosis according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	FGF23	fibroblast growth factor 23	11.1	Summaries, Publications
2	SAMD9	sterile alpha motif domain containing 9	11.1	Summaries, Publications
3	GALNT3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	11.0	Publications
4	KL	klotho	11.0	Publications
5	RGL2	ral guanine nucleotide dissociation stimulator-like 2	11.0	Publications
6	EGR1	early growth response 1	11.0	Publications
7	TNF	tumor necrosis factor	11.0	Publications
8	CENPB	centromere protein B, 80kDa	11.0
9	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
10	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0
11	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0
12	LMNA	lamin A/C	11.0	Publications
13	ANKH	ankylosis, progressive homolog (mouse)	11.0
14	SPP1	secreted phosphoprotein 1	11.0	Publications
15	FBN1	fibrillin 1	11.0
16	GNAS	GNAS complex locus	11.0	Publications
17	APITD1	apoptosis-inducing, TAF9-like domain 1	11.0
18	SAMD9L	sterile alpha motif domain containing 9-like	11.0
19	MGP	matrix Gla protein	11.0	Publications
20	MEPE	matrix extracellular phosphoglycoprotein	11.0	Publications
21	EMP1	epithelial membrane protein 1	11.0
22	ZMPSTE24	zinc metallopeptidase STE24 homolog (S. cerevisiae)	11.0	Publications
23	KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	11.0	Publications
24	ALPPL2	alkaline phosphatase, placental-like 2	11.0
25	AHSG	alpha-2-HS-glycoprotein	11.0
26	PTH	parathyroid hormone	11.0	Publications
27	TGFB3	transforming growth factor, beta 3	11.0	Publications
28	ALPL	alkaline phosphatase, liver/bone/kidney	11.0
29	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
30	GTDC2	glycosyltransferase-like domain containing 2	11.0	Publications, Disorders
31	ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	11.0
32	DSPP	dentin sialophosphoprotein	11.0	Publications
33	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
34	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.0
35	KITLG	KIT ligand	11.0	Publications
36	CASR	calcium-sensing receptor	11.0
37	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
38	ALPP	alkaline phosphatase, placental	11.0
39	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
40	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
41	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
42	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications

Pathways related to calcinosis according to GeneDecks:

(show all 30)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.4	KIR3DL2, HLA-DQA1
2	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.2	GNAS, PTH, SPP1, EGR1
3	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.2	EGR1, SPP1, PTH, GNAS
4	Immune response Antigen presentation by MHC class II10	10.1	HLA-DQA1
5	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.9	SPP1, PTH, TNF, CALCA
6	Dilated cardiomyopathy20	9.9	LMNA, GNAS, TNF, TGFB3
7	Folate biosynthesis20	9.9	ALPL, ALPP, ALPPL2
8	PTEN Pathway36	9.9	FBN1, MEPE, FGF23, KITLG
9	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.9	SPP1, PTH, TNF, CALCA
10	NAD metabolism41	9.8	ALPPL2, ALPP, ALPL, ENPP1
11	NAD metabolism10	9.8	ALPPL2, ALPP, ALPL, ENPP1
12	ILK Signaling36	9.5	TGFB3, SPP1, TNF, FBN1, MEPE, FGF23
13	Inhibition of Angiogenesis by TSP136	9.5	TGFB3, SPP1, FBN1, MEPE
14	MAPK Signaling36	9.5	TGFB3, SPP1, TNF, FBN1, MEPE, FGF23
15	Rho Family GTPases36	9.3	TGFB3, SPP1, TNF, FBN1, MEPE, FGF23
16	Asthma20	9.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
17	Allograft rejection20	9.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
18	THC Differentiation Pathway36	9.1	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
19	Type I diabetes mellitus20	9.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
20	MHC class II antigen presentation38	9.1	HLA-DQA1, HLA-DQB1, HLA-DRB1
21	G-protein signaling N-RAS regulation pathway10	9.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, RGL2
22	G-protein signaling_N-RAS regulation pathway41	9.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, RGL2
23	Antigen processing and presentation20	8.9	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, KIR3DL2
24	Leishmaniasis20	8.9	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, TGFB3
25	Rheumatoid arthritis20	8.9	TGFB3, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
26	ICos-ICosL Pathway in T-Helper Cell36	8.9	PIK3C2A, HLA-DQA1, HLA-DQB1, HLA-DRB1
27	Toxoplasmosis20	8.8	TGFB3, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
28	CD28 Signaling in T-Helper Cell36	8.7	PIK3C2A, HLA-DQA1, HLA-DQB1, HLA-DRB1
29	Tuberculosis20	8.6	TGFB3, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
30	NFAT in Immune Response36	8.4	TGFB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, FGF23, KITLG

Compounds related to calcinosis according to GeneDecks:

(show top 50)    (show all 87)

id	Compound	Score	Top Affiliating Genes
1	methylmethacrylate32	10.2	DSPP, SPARC, SPP1
2	pge232	10.0	EGR1, CASR, GNAS, SPP1, SPARC
3	glucose32	9.9	AHSG, SPARC, PTH, CASR
4	amifostine32 9 9	11.9	ALPL, ENPP1, KITLG, ALPPL2
5	alizarin32	9.9	ALPL, SPARC, SPP1, ALPP
6	7,8-dihydroneopterin32 18	10.8	ALPL, ALPPL2, ALPP
7	dihydroxyacetone32 18	10.8	ALPL, ALPP, ALPPL2
8	levamisole32 9 9	11.8	SPP1, ALPPL2, ALPP, ALPL
9	dihydroneopterin triphosphate32 18	10.8	ALPL, ALPP, ALPPL2
10	tgf beta132	9.7	KITLG, TGFB3, SPP1, TNF, FBN1, SPARC
11	procollagen32	9.6	ZMPSTE24, ALPP, PTH, SPARC, SPP1
12	calcium carbonate32	9.5	ALPP, CALCA, PTH, DSPP
13	creatinine32	9.4	CEACAM3, LMNA, SPP1, PTH, KITLG, FGF23
14	pamidronate32 9 9	11.4	CASR, CALCA, PTH, ALPP
15	hydroxyproline32 18	10.4	PTH, AHSG, FBN1, CALCA, ALPP, SPARC
16	alendronate32 9 9	11.3	CALCA, PTH, DSPP, ALPP
17	fibrinogen32	9.3	SPP1, SPARC, EGR1, TNF, GPT, CEACAM3
18	pyrophosphate32 18	10.2	PIK3C2A, MGP, ANKH, ALPL, ALPP, SPP1
19	25-hydroxyvitamin d32	9.2	FGF23, ALPP, PTH, CALCA, SPP1, CASR
20	ribonucleic acid32	9.2	SPP1, EGR1, TGFB3, PTH, CASR, GNAS
21	ethanol32 34 9 18 9	13.1	EGR1, ALPL, SPARC, ALPPL2, GPT, KITLG
22	thymidine32 18	9.8	SPARC, EGR1, CEACAM3, PTH, TNF, GNAS
23	heparin32 9 18 9	11.8	SPARC, SPP1, ALPP, FBN1, GTDC2, KITLG
24	1,25 dihydroxy vitamin d332	8.8	CASR, EGR1, PHEX, SPP1, CALCA, FGF23
25	thyroxine32 18	9.8	CALCA, GPT, ALPP, CEACAM3, PIK3C2A, PTH
26	isoflurane32 9 9	10.7	CALCA, SLC6A3, PIK3C2A, GPT, ALPP
27	cysteine32	8.7	CASR, ALPL, AHSG, FBN1, GTDC2, ALPP
28	dexamethasone32 42 34 9 9	12.7	TGFB3, ENPP1, ALPP, PTH, TNF, SPP1
29	paraffin32	8.5	DSPP, SPARC, TGFB3, HLA-DQA1, ALPPL2, ALPP
30	testosterone32 9 18 9	11.4	PTH, SPP1, SPARC, KITLG, CALCA, ALPP
31	retinoic acid32 42 18	10.4	SPP1, LMNA, MGP, TNF, ALPP, ALPL
32	methotrexate32 34 42 9 9	12.3	PIK3C2A, KITLG, CEACAM3, GPT, HLA-DRB1, TNF
33	glutamate32	8.3	DSPP, MGP, GPT, ALPP, CASR, GNAS
34	vegf32	8.3	TNF, PTH, SPP1, SPARC, KL, EGR1
35	phosphorus32	8.3	PTH, SPP1, PHEX, CASR, CALCA, ALPP
36	norepinephrine32 9 18 9	11.3	ALPP, KITLG, PIK3C2A, GNAS, CALCA, EGR1
37	cyclosporin a32 42	9.2	SPP1, TNF, ALPP, GPT, EGR1, PIK3C2A
38	hydroxyapatite32	8.2	CASR, SPP1, SPARC, EGR1, DSPP, ENPP1
39	lactate32	8.1	SPARC, CEACAM3, SPP1, TNF, ALPP, CALCA
40	cholesterol32 9 18 9	11.1	LMNA, ZMPSTE24, GPT, CEACAM3, MGP, ALPP
41	oligonucleotide32	8.1	EGR1, SPARC, SPP1, CENPB, HLA-DQA1, ALPL
42	aspartate32	8.0	PIK3C2A, ALPL, HLA-DQA1, HLA-DQB1, CEACAM3, DSPP
43	calcitriol32 42 9 18 9	11.6	DSPP, PHEX, SPARC, TNF, KITLG, MGP
44	estrogen32	7.5	EGR1, DSPP, KITLG, MGP, FBN1, SPP1
45	vitamin d32	7.3	ALPL, ALPP, GPT, FBN1, FGF23, MGP
46	serine32	7.0	SLC6A3, ALPP, ABO, KITLG, LMNA, ZMPSTE24
47	tyrosine32	6.9	HLA-DQB1, PTH, HLA-DRB1, SPARC, EGR1, AHSG
48	arginine32	6.6	GNAS, ALPP, GPT, FBN1, FGF23, ABO
49	alanine32	6.4	FBN1, SPP1, ABO, DSPP, SLC6A3, EMP1
50	calcium32 9 18 9	9.3	ALPP, GNAS, SPARC, CASR, CALCA, PTH

Cellular components related to calcinosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	9.5	MGP, MEPE, FBN1, SPARC, DSPP
2	MHC class II protein complex	GO:042613	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1
3	clathrin-coated endocytic vesicle membrane	GO:030669	8.9	HLA-DQA1, HLA-DQB1, HLA-DRB1
4	trans-Golgi network membrane	GO:032588	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, GNAS
5	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1
6	ER to Golgi transport vesicle membrane	GO:012507	8.8	HLA-DQA1, HLA-DQB1, HLA-DRB1
7	transport vesicle membrane	GO:030658	8.5	HLA-DRB1, HLA-DQB1, HLA-DQA1
8	extracellular space	GO:005615	8.1	KL, TGFB3, AHSG, SPARC, SPP1, PTH
9	extracellular region	GO:005576	8.0	SPP1, SPARC, ABO, AHSG, TGFB3, PTH
10	plasma membrane	GO:005886	5.2	HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, PHEX, TGFB3

Biological processes related to calcinosis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequestering of triglyceride	GO:030730	10.1	TNF, ENPP1
2	negative regulation of bone mineralization	GO:030502	10.0	FGF23, MEPE, AHSG
3	regulation of bone mineralization	GO:030500	10.0	MGP, ENPP1, ANKH, AHSG
4	positive regulation of bone mineralization	GO:030501	9.9	TGFB3, PTH, KL
5	biomineral tissue development	GO:031214	9.6	DSPP, PHEX, SPP1, ENPP1, MEPE
6	ossification	GO:001503	9.4	DSPP, AHSG, SPARC, CASR, MGP
7	skeletal system development	GO:001501	9.0	MEPE, DSPP, AHSG, PHEX, PTH, ALPL
8	aging	GO:007568	8.8	TGFB3, CALCA, KL, SLC6A3

Molecular functions related to calcinosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:005201	9.7	MGP, MEPE, FBN1, DSPP
2	alkaline phosphatase activity	GO:004035	9.5	ALPL, ALPP, ALPPL2
3	MHC class II receptor activity	GO:032395	8.5	HLA-DRB1, HLA-DQB1, HLA-DQA1