Summaries for Calcinosis

About this section


Wikipedia:63 Calcinosis is the formation of calcium deposits in any soft tissue. more...

MalaCards based summary: Calcinosis, also known as pathologically calcified structure, is related to familial tumoral calcinosis and tumoral calcinosis, hyperphosphatemic, familial. An important gene associated with Calcinosis is FGF23 (fibroblast growth factor 23), and among its related pathways are FGFR ligand binding and activation and Insulin receptor signalling cascade. The compounds 25-hydroxyvitamin d and phosphorus have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and skin, and related mouse phenotypes are other and limbs/digits/tail.

Disease Ontology:9 A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.

Aliases & Classifications for Calcinosis

About this section

Calcinosis, Aliases & Descriptions:

Name: Calcinosis 9 11 43 60
Pathologically Calcified Structure 9
 
Pathologic Calcification 9


External Ids:

Disease Ontology9 DOID:182
MeSH33 D002114

Related Diseases for Calcinosis

About this section

Diseases related to Calcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1familial tumoral calcinosis31.5FGF23, GALNT3
2tumoral calcinosis, hyperphosphatemic, familial31.3KL, FGF23
3hyperostosis30.8GALNT3, FGF23
4hyperparathyroidism30.6KL, FGF23
5hyperphosphatemia30.4SPP1, KL, GALNT3, FGF23
6hypervitaminosis d30.4FGF23, KL
7arthropathy30.2TNF, FGF23
8osteoporosis29.8FGF23, KL, SPP1
9primary hyperoxaluria29.5FGF23, ENPP1, SPP1
10atherosclerosis29.2SPP1, TNF, ENPP1, FGF23
11dermatomyositis10.8
12scleroderma10.5
13crest syndrome10.4
14cervicitis10.4
15rickets10.4FGF23
16coronary restenosis10.4SPP1
17tumoral calcinosis, familial, normophosphatemic10.3
18lupus erythematosus10.3
19adult dermatomyositis10.3
20arteriosclerosis10.3SPP1
21hypoparathyroidism10.3
22connective tissue disease10.3
23systemic lupus erythematosus10.3
24systemic scleroderma10.2
25limited scleroderma10.2
26calciphylaxis10.2
27myositis10.2
28peritonitis10.2
29pseudohypoparathyroidism10.2
30familial idiopathic basal ganglia calcification10.2
31pulmonary emphysema10.2FGF23, KL
32hypophosphatemia10.2FGF23, KL
33osteomalacia10.2FGF23, KL
34nephrolithiasis10.2SPP1, FGF23
35synovitis10.1TNF
36arthritis10.1
37burn scar10.1
38burns10.1
39leukemia10.1
40hypercalcemia10.1
41cerebritis10.1
42down syndrome10.1
43esophagitis10.1
44osteomyelitis10.1
45panniculitis10.1
46antisynthetase syndrome10.1
47chronic recurrent multifocal osteomyelitis10.1
48linear scleroderma10.1
49hyperphosphatemic familial tumoral calcinosis, galnt3-related10.1
50hyperphosphatemic familial tumoral calcinosis, fgf23-related10.1

Graphical network of the top 20 diseases related to Calcinosis:



Diseases related to calcinosis

Symptoms for Calcinosis

About this section

Drugs & Therapeutics for Calcinosis

About this section

Drug clinical trials:

Search ClinicalTrials for Calcinosis

Search NIH Clinical Center for Calcinosis

Genetic Tests for Calcinosis

About this section

Anatomical Context for Calcinosis

About this section

MalaCards organs/tissues related to Calcinosis:

31
Brain, Bone, Skin, Breast, Lung, Spinal cord, Heart, Kidney, Liver, Myeloid, T cells, Tongue

Animal Models for Calcinosis or affiliated genes

About this section

Publications for Calcinosis

About this section

Articles related to Calcinosis:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Calcinosis cutis presenting in the context of long-term therapy for chronic myeloid leukemia: a case report and review of the literature. (25785904)
2015
2
Dual-energy computed tomography for the evaluation of calcinosis in systemic sclerosis. (25641967)
2015
3
A unique association of unilateral idiopathic calcinosis cutis with ipsilateral porokeratotic eccrine ostial and dermal duct nevus. (25644046)
2015
4
Idiopathic calcinosis cutis. (24401976)
2014
5
Familial tumoral calcinosis. (25351424)
2014
6
Systemic sarcoidosis diagnosed by panniculitis mimicking olecranon bursitis associated to fingertip calcinosis cutis. (25484407)
2014
7
Normocalcemic primary hyperparathyroidism presenting as calcinosis cutis. (25160019)
2014
8
Atypical occipital calcinosis in a caucasian individual with probable diffuse neurofibrillary tangles with calcification. (25333560)
2014
9
Severe vascular calcification and tumoral calcinosis in a family with hyperphosphatemia: a fibroblast growth factor 23 mutation identified by exome sequencing. (25378588)
2014
10
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. (23426499)
2013
11
Gastric Mucosal Calcinosis: A Rare Cause of Bleeding. (24135468)
2013
12
Successful treatment of calcinosis with infliximab in a patient with systemic sclerosis/myositis overlap syndrome. (24255162)
2013
13
Idiopathic scrotal calcinosis: A rare entity and a review of the literature. (23826060)
2013
14
Cutaneous calcinosis in juvenile dermatomyositis. (23608558)
2013
15
Enzootic calcinosis caused by Nierembergia rivularis in sheep. (22379059)
2012
16
Calcinosis cutis in autoimmune connective tissue diseases. (22741938)
2012
17
Huge recurrent tumoral calcinosis needing extensive excision and reconstruction: report of a rare case and brief literature review. (22653143)
2012
18
Sporotrichoid-like calcinosis cutis and calcifications in vessel walls and eccrine sweat glands following intravenous infusion of calcium gluconate. (21967298)
2012
19
Metastatic calcinosis cutis in patients of end-stage renal disease. (22268796)
2012
20
Poikiloderma with neutropenia: report of three cases including one with calcinosis cutis. (21967010)
2012
21
Tumoral calcinosis--a pathogenetic overview: a histological and ultrastructural study with a report of two new cases, one in infancy. (22614164)
2012
22
Normophosphatemic type tumoral calcinosis associated with chronic recurrent multifocal osteomyelitis: a case report. (21610312)
2011
23
Idiopathic calcinosis cutis in a child: chemical composition of the calcified deposits. (21540566)
2011
24
Calcinosis cutis. (21813938)
2011
25
Thoracic outlet syndrome with involvement of the cervical sympathetics because of idiopathic tumoral calcinosis. (21389840)
2011
26
Miscellaneous non-inflammatory musculoskeletal conditions. Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and I+Klotho). (22142751)
2011
27
Tumoral calcinosis presenting as a deformity of the thoracic spine. (22132916)
2011
28
Metastatic calcinosis (including calcinosis cutis) in a young dog with multiple urinary tract abnormalities. (21410567)
2011
29
Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome. (20465653)
2010
30
GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. (18976705)
2009
31
A novel recessive mutation of fibroblast growth factor-23 in tumoral calcinosis. (19411468)
2009
32
Calcinosis cutis associated with amyopathic dermatomyositis: response to intravenous immunoglobulin. (19467386)
2009
33
Tumoral calcinosis of the hand. (19226078)
2008
34
Tumoral calcinosis with vitamin D deficiency. (18974584)
2008
35
Fine-needle aspiration biopsy cytology of cutaneous calcinosis in a 74-year-old woman with dermatomyositis on methotrexate therapy: a case report. (18702364)
2008
36
Calcinosis in juvenile dermatomyositis. (18820391)
2008
37
Treatment of Achilles tendon calcinosis in juvenile dermatomyositis with external ilizarov fixator. (18078630)
2007
38
Scrotal calcinosis: pathogenesis and case report. (16001101)
2005
39
Resolution of tumoral calcinosis in a hemodialysis patient using low calcium dialysate. (15681261)
2005
40
Calcinosis universalis in systemic sclerosis with limited scleroderma. (15789907)
2005
41
A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: evidence that the disorder is autosomal recessive. (15687324)
2005
42
A pilot study of acetic acid iontophoresis and ultrasound in the treatment of systemic sclerosis-related calcinosis. (15644389)
2005
43
Tumoral calcinosis with hyperphosphatemia. (16272668)
2005
44
A case of massive dystrophic cardiac calcinosis with increased bone resorption markers: a novel pathophysiologic link? (15476567)
2004
45
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
46
What's your diagnosis: Tumoral calcinosis. (17344714)
1998
47
Image of the month. CREST syndrome: calcinosis cutis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis. (9178667)
1997
48
Soft-tissue chondroma as a cause of calcinosis in a patient with CREST syndrome. (8457459)
1993
49
Uremic tumoral calcinosis: preliminary observations suggesting an association with aberrant vitamin D homeostasis. (1962658)
1991
50
Calcinosis in a burn scar. (21065273)
1946

Variations for Calcinosis

About this section

Expression for genes affiliated with Calcinosis

About this section
Search GEO for disease gene expression data for Calcinosis.

Pathways for genes affiliated with Calcinosis

About this section

Pathways related to Calcinosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6FGF23, KL
2
Show member pathways
9.6FGF23, KL
39.6SPP1, FGF23
49.3SPP1, TNF
59.3TNF, SPP1
6
Show member pathways
9.1ENPP1, KL
79.1ENPP1, SPP1
8
Show member pathways
9.1SPP1, KL, FGF23
9
Show member pathways
9.0FGF23, TNF, SPP1

Compounds for genes affiliated with Calcinosis

About this section

Compounds related to Calcinosis according to GeneCards Suite gene sharing:

(show all 14)
idCompoundScoreTop Affiliating Genes
125-hydroxyvitamin d439.8FGF23, SPP1
2phosphorus439.8SPP1, FGF23
31,25 dihydroxy vitamin d3439.6SPP1, FGF23
4mycophenolate mofetil43 49 1211.5TNF, SPP1
5infliximab43 49 1211.5SPP1, TNF
6glucosamine43 24 1211.5SPP1, TNF
7troglitazone43 28 59 1212.3TNF, SPP1
8calcitriol43 59 24 1212.2FGF23, TNF, SPP1
9hydroxyapatite439.0FGF23, ENPP1, SPP1
10vegf438.5KL, TNF, SPP1
11dexamethasone43 49 28 1211.4ENPP1, TNF, SPP1
12tyrosine438.3FGF23, ENPP1, KL, SPP1
13serine438.2SPP1, TNF, ENPP1, FGF23
14calcium43 49 24 1211.0SPP1, KL, GALNT3, ENPP1, FGF23

GO Terms for genes affiliated with Calcinosis

About this section

Cellular components related to Calcinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.4FGF23, KL, TNF, SPP1
2extracellular spaceGO:00056157.3FGF23, ENPP1, KL, TNF, SPP1

Biological processes related to Calcinosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:00900809.8KL, FGF23
2phosphatidylinositol-mediated signalingGO:00480159.6FGF23, KL
3negative regulation of osteoblast differentiationGO:00456689.5FGF23, TNF
4cellular phosphate ion homeostasisGO:00306439.5ENPP1, FGF23
5phosphate-containing compound metabolic processGO:00067969.4FGF23, ENPP1
6sequestering of triglycerideGO:00307309.3ENPP1, TNF
7biomineral tissue developmentGO:00312149.2SPP1, ENPP1
8positive regulation of ERK1 and ERK2 cascadeGO:00703749.2FGF23, TNF
9negative regulation of glucose importGO:00463259.2ENPP1, TNF
10negative regulation of fat cell differentiationGO:00455998.9ENPP1, TNF

Products for genes affiliated with Calcinosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Calcinosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet