MCID: CLC006
MIFTS: 50

Calcinosis malady

Categories: Metabolic diseases

Aliases & Classifications for Calcinosis

Aliases & Descriptions for Calcinosis:

Name: Calcinosis 12 29 52 42 14 69
Pathologically Calcified Structure 12
Pathologic Calcification 12

Classifications:



External Ids:

Disease Ontology 12 DOID:182
MeSH 42 D002114
NCIt 47 C3672
UMLS 69 C0006663

Summaries for Calcinosis

Disease Ontology : 12 A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.

MalaCards based summary : Calcinosis, also known as pathologically calcified structure, is related to cole disease and tumoral calcinosis, hyperphosphatemic, familial. An important gene associated with Calcinosis is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways are Signaling by FGFR2 and Endochondral Ossification. The drugs Alendronate and Pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and skin, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 71 Calcinosis is the formation of calcium deposits in any soft... more...

Related Diseases for Calcinosis

Diseases related to Calcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
id Related Disease Score Top Affiliating Genes
1 cole disease 31.3 ENPP1 GALNT3 MGP
2 tumoral calcinosis, hyperphosphatemic, familial 12.4
3 tumoral calcinosis, familial, normophosphatemic 12.2
4 familial tumoral calcinosis 11.9
5 crest syndrome 11.7
6 hyperphosphatemic familial tumoral calcinosis, fgf23-related 11.7
7 hyperphosphatemic familial tumoral calcinosis, galnt3-related 11.7
8 hyperphosphatemic familial tumoral calcinosis, kl-related 11.7
9 mandibuloacral dysplasia 11.3
10 dermatomyositis 11.3
11 primary familial brain calcification 11.1
12 nephrocalcinosis 11.1
13 basal ganglia calcification, idiopathic, 1 10.9
14 reynolds syndrome 10.7
15 diffuse idiopathic skeletal hyperostosis 10.7
16 scleroderma, familial progressive 10.7
17 idiopathic basal ganglia calcification childhood-onset 10.7
18 oligospermia 10.3 FGF23 KL
19 wiedemann-steiner syndrome 10.3 FGF23 PHEX
20 lymphangioleiomyomatosis 10.2 FGF23 PHEX
21 orbit lymphoma 10.2 FGF23 GALNT3 KL
22 donnai-barrow syndrome 10.2 FGF23 GALNT3 KL
23 frozen shoulder 10.2 GALNT3 SPP1
24 peroxisome biogenesis disorder 2b 10.2 FGF23 GALNT3 PHEX
25 acute maxillary sinusitis 10.2 FGF23 PHEX
26 coffin-lowry syndrome 10.2 FGF23 KL PHEX
27 opthalmoplegia mental retardation lingua scrotalis 10.2 FGF23 PHEX
28 serous cystadenocarcinoma 10.1 SPARC SPP1
29 gastric antral vascular ectasia 10.1 FGF23 GALNT3 KL PHEX
30 maroteaux stanescu cousin syndrome 10.1 CALCA FGF23 PHEX
31 auditory system disease 10.1 KL LMNA
32 weill-marchesani syndrome 10.1 FGF23 GALNT3 KL MGP
33 cervicitis 10.1
34 post-traumatic stress disorder 10.1 ANKH FGF23 GALNT3
35 gonococcal seminal vesiculitis 10.1 CALCA GALNT3
36 pre-eclampsia 10.1 CALCA FGF23 PHEX
37 ischemic bone disease 10.1 CALCA FGF23 PHEX
38 subserous uterine fibroid 10.1 CALCA FGF23 PHEX
39 hyperphosphatemia 10.0
40 axial osteomalacia 10.0 CALCA FGF23 SPARC
41 myelophthisic anemia 10.0 KL MGP SPP1
42 myofascial pain syndrome 10.0 CALCA SPP1
43 long qt syndrome-11 10.0 CALCA GALNT3 RGL2 SAMD9
44 lupus erythematosus 10.0
45 familial atrial fibrillation 10.0 ENPP1 FGF23 PHEX
46 x-linked hereditary ataxia 10.0 ENPP1 FGF23 PHEX
47 childhood parosteal osteogenic sarcoma 10.0 ENPP1 SPP1
48 prostate cancer, hereditary, x-linked 2 10.0 ENPP1 FGF23 PHEX
49 opportunistic bacterial infectious disease 10.0 ENPP1 FGF23 PHEX
50 adult dermatomyositis 9.9

Graphical network of the top 20 diseases related to Calcinosis:



Diseases related to Calcinosis

Symptoms & Phenotypes for Calcinosis

MGI Mouse Phenotypes related to Calcinosis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 AHSG ANKH ENPP1 FGF23 GALNT3 KL
2 homeostasis/metabolism MP:0005376 10.17 FGF23 GALNT3 KL LMNA MGP PHEX
3 cardiovascular system MP:0005385 10.11 GALNT3 KL LMNA MGP SPP1 ANKH
4 immune system MP:0005387 10.06 ANKH ENPP1 FGF23 GALNT3 KL LMNA
5 craniofacial MP:0005382 9.97 ANKH GALNT3 LMNA PHEX SPARC SPP1
6 limbs/digits/tail MP:0005371 9.92 ANKH FGF23 GALNT3 KL LMNA PHEX
7 integument MP:0010771 9.91 ENPP1 FGF23 GALNT3 KL LMNA SPARC
8 hearing/vestibular/ear MP:0005377 9.85 AHSG ANKH ENPP1 LMNA PHEX
9 muscle MP:0005369 9.8 AHSG ANKH ENPP1 KL LMNA MGP
10 renal/urinary system MP:0005367 9.76 ENPP1 FGF23 GALNT3 KL LMNA MGP
11 respiratory system MP:0005388 9.43 ANKH FGF23 KL LMNA MGP SPP1
12 skeleton MP:0005390 9.36 AHSG ANKH ENPP1 FGF23 GALNT3 KL

Drugs & Therapeutics for Calcinosis

Drugs for Calcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 310)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4,Phase 2 121268-17-5, 66376-36-1 2088
2
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
3
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
4
Fluvastatin Approved Phase 4 93957-54-1 1548972
5
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3 122320-73-4 77999
6
Sevelamer Approved Phase 4,Phase 3,Phase 2 52757-95-6, 152751-57-0 3085017
7
Everolimus Approved Phase 4 159351-69-6 6442177
8
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
9
Calcium acetate Approved Phase 4 62-54-4
10
Dalteparin Approved Phase 4 9041-08-1
11
Methyltestosterone Approved Phase 4 58-18-4 6010
12
Testosterone Approved, Investigational Phase 4 58-22-0 6013
13
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
14
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
15
Mycophenolic acid Approved Phase 4 24280-93-1 446541
16
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
17
Apixaban Approved Phase 4 503612-47-3 10182969
18
Warfarin Approved Phase 4 81-81-2 6691 54678486
19
Adenosine Approved, Investigational Phase 4 58-61-7 60961
20
Regadenoson Approved Phase 4 313348-27-5 219024
21
Calcium carbonate Approved Phase 4,Phase 3,Phase 2,Phase 1 471-34-1
22
Simvastatin Approved Phase 4 79902-63-9 54454
23
Amlodipine Approved Phase 4 88150-42-9 2162
24
Phenprocoumon Approved Phase 4 435-97-2 9908 54680692
25
Rivaroxaban Approved Phase 4 366789-02-8
26
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
27
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
28
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
29
Denosumab Approved Phase 4,Phase 3,Phase 2 615258-40-7
30
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
31
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2 67-97-0 6221 10883523 5280795
32
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2 50-14-6 5280793
33
Menadione Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-27-5 4055
34
Phytonadione Approved, Nutraceutical Phase 4,Phase 3,Phase 2 84-80-0 4812 5284607
35
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 134070 5280453
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
37
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 59-67-6 938
38
Nicotinamide Approved, Nutraceutical Phase 4,Phase 3,Phase 2 98-92-0 936
39 Antifibrinolytic Agents Phase 4,Phase 3,Phase 2
40 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
42 Coagulants Phase 4,Phase 3,Phase 2
43 Ergocalciferols Phase 4,Phase 2
44 Hemostatics Phase 4,Phase 3,Phase 2
45 Micronutrients Phase 4,Phase 2,Phase 3
46 Trace Elements Phase 4,Phase 2,Phase 3
47 vitamin d Phase 4,Phase 3,Phase 2
48 Vitamin K 2 Phase 4,Phase 3,Phase 2
49 Vitamin MK 7 Phase 4,Phase 3,Phase 2
50 Vitamins Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 362)
id Name Status NCT ID Phase
1 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4
2 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4
3 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4
4 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4
5 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4
6 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4
7 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4
8 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4
9 TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography Unknown status NCT01972022 Phase 4
10 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4
11 The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers Unknown status NCT01526304 Phase 4
12 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4
13 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4
14 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4
15 Can Alendronate Suppress Calcification and Improve Bone Density in Chronic Peritoneal Dialysis Patients? Completed NCT00261625 Phase 4
16 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4
17 Apixaban Versus Warfarin in the Evaluation of Progression of Atherosclerotic Calcification and Vulnerable Plaque Completed NCT02090075 Phase 4
18 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4
19 Parathyroidectomy in Endstage Renal Disease Completed NCT00745719 Phase 4
20 Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients Completed NCT00745225 Phase 4
21 The XLIMUS-DES in Very Complex Lesions Completed NCT02360020 Phase 4
22 Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY) Completed NCT00295191 Phase 4
23 Sevelamer, Fetuin-A and Endothelial Dysfunction in CKD Completed NCT00486772 Phase 4
24 Sevelamer, FGF-23 and Endothelial Dysfunction in Chronic Kidney Disease (CKD) Completed NCT01135615 Phase 4
25 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4
26 Effect of Atorvastatin on Bone-vascular Axis Completed NCT02342015 Phase 4
27 Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol Completed NCT01748396 Phase 4
28 Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed NCT00471549 Phase 4
29 Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism Completed NCT01143987 Phase 4
30 Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure Completed NCT00124969 Phase 4
31 REmoval of Free Light Chains. A COmpaRison of Three Different dialyzERs Completed NCT02950389 Phase 4
32 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4
33 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4
34 Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level Completed NCT01101113 Phase 4
35 Efficacy and Safety of Paricalcitol in the Reduction of Secondary Hyperparathyroidism After Kidney Transplantation. Completed NCT01939977 Phase 4
36 Comparison of Four and Eight Hours Dialysis Sessions in Thrice Weekly Hemodialysis Completed NCT00413803 Phase 4
37 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Recruiting NCT02610933 Phase 4
38 Rivaroxaban Compared to Vitamin K Antagonist Upon Development of Cardiovascular Calcification Recruiting NCT02066662 Phase 4
39 Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation Recruiting NCT02161965 Phase 4
40 Effect of Vitamin D3 Supplementation on Arterial and Bone Remodeling in Chronic Kidney Disease Patients Recruiting NCT02999204 Phase 4
41 Assessment of Osteoblastic Activity With 18F-Fluoride in Aortic Bioprosthesis Structural Valve Dysfunction (SVD) Recruiting NCT03015818 Phase 4
42 Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium Recruiting NCT02376010 Phase 4
43 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Recruiting NCT02661295 Phase 4
44 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection Recruiting NCT02403856 Phase 4
45 Effect of 12 Weeks Treatment With Tadalafil vs Placebo on Lower Urinary Tract Symptoms Secondary to Prostatic Hyperplasia Recruiting NCT02252367 Phase 4
46 Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis Active, not recruiting NCT02598635 Phase 4
47 Intravenous Paricalcitol in Chronic Hemodialysis Patients Active, not recruiting NCT03023748 Phase 4
48 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Active, not recruiting NCT02366975 Phase 4
49 The PARTNER TRIAL - Post Approval Study Part II Active, not recruiting NCT02184442 Phase 4
50 EARly Prevention of aTHeroma Progression Active, not recruiting NCT02105623 Phase 4

Search NIH Clinical Center for Calcinosis

Cochrane evidence based reviews: calcinosis

Genetic Tests for Calcinosis

Genetic tests related to Calcinosis:

id Genetic test Affiliating Genes
1 Calcinosis 29

Anatomical Context for Calcinosis

MalaCards organs/tissues related to Calcinosis:

39
Brain, Bone, Skin, Breast, Kidney, Lung, Liver

Publications for Calcinosis

Articles related to Calcinosis:

(show top 50) (show all 689)
id Title Authors Year
1
Metastatic Calcinosis of Aortic Valve Secondary to Renal Failure Mimicking Infective Endocarditis. ( 27738529 )
2016
2
Progressive myelopathy in systemic sclerosis patient with cervical intraspinal calcinosis. ( 27177768 )
2016
3
Acro-osteolysis & calcinosis in scleroderma. ( 27834340 )
2016
4
Scintigraphic Images of Massive Tumoral Calcinosis. ( 26909717 )
2016
5
Nontraumatic tumoral calcinosis. ( 27663758 )
2016
6
Bilateral strio-pallido-dentate calcinosis (Fahr's disease): report of seven cases and revision of literature. ( 27608765 )
2016
7
Idiopathic tumoral calcinosis-like lesion in the lower cervical spine causing acute central cord syndrome: case report. ( 27611507 )
2016
8
Central cord syndrome in a patient with systemic sclerosis and cervical calcinosis: case report and review of literature. ( 28053731 )
2016
9
OsmoPrep-associated Gastritis: A Histopathologic Mimic of Iron Pill Gastritis and Mucosal Calcinosis. ( 27454942 )
2016
10
Calcinosis in poly-dermatomyositis: clinical and laboratory predictors and treatment options. ( 27908312 )
2016
11
Worsening of Calcinosis Cutis with Teriparatide treatment in two osteoporotic patients. ( 26992073 )
2016
12
Acro-osteolysis and calcinosis in patient with scleroderma: A case report. ( 28017514 )
2016
13
Pathomorphological features of calcinosis circumscripta in a dog. ( 27051446 )
2016
14
Extensive bilateral striopallidodentate calcinosis: a 50A years history of hypoparathyroidism presenting like a parkinsonian syndrome. ( 27485169 )
2016
15
Uraemic tumoural calcinosis. ( 26912772 )
2016
16
ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review. ( 27665458 )
2016
17
Assessment and Surgical Treatment of Calcinosis of the Shoulder Associated with CREST Syndrome. ( 27437158 )
2016
18
Safety and efficacy of extracorporeal shock wave therapy (ESWT) in calcinosis cutis associated with systemic sclerosis. ( 27494629 )
2016
19
Phenotypic and Genotypic Characterization and Treatment of a Cohort with Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome. ( 27164190 )
2016
20
Diffuse calcinosis cutis in systemic lupus erythematosus: an exceptional complication. ( 26873649 )
2016
21
Iatrogenic calcinosis cutis: A rare cytological diagnosis. ( 27756992 )
2016
22
A Novel Approach in the Treatment of Calcinosis Cutis. ( 27660938 )
2016
23
Laxative Related Primary Hyperphosphatemic Tumoral Calcinosis Identified by Bone Scintigraphy. ( 27651742 )
2016
24
Milia-like idiopathic calcinosis cutis in a child with Down syndrome. ( 27617523 )
2016
25
Systemic lupus erythematosus-related hypercalcemia with ectopic calcinosis. ( 27136920 )
2016
26
Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis. ( 27867679 )
2016
27
Topical Sodium thiosulfate: a treatment for calcifications in hyperphosphatemic familial tumoral calcinosis? ( 27163355 )
2016
28
Calcinosis cutis universalis. ( 27507016 )
2016
29
Idiopathic Scrotal Calcinosis. ( 27574356 )
2016
30
Calcinosis in juvenile dermatomyositis mimicking cold abscess. ( 27586213 )
2016
31
Universalis Calcinosis in Adult Dermatomyositis: An "Anti-NXP2 Syndrome". ( 27660942 )
2016
32
The erbium:YAG Laser: a new technique for the treatment of scrotal calcinosis. ( 27606883 )
2016
33
A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report. ( 27088846 )
2016
34
Calcinosis is associated with digital ischaemia in systemic sclerosis-a longitudinal study. ( 27593964 )
2016
35
Iatrogenic Calcinosis Cutis of the Upper Limb Arising from the Extravasation of Intravenous Anticancer Drugs in a Patient with Acute Lymphoblastic Leukemia. ( 27019816 )
2016
36
Hartsfield syndrome associated with a novel heterozygous missense mutation in FGFR1 and incorporating tumoral calcinosis. ( 27170295 )
2016
37
Tumoral Calcinosis: An Uncommon Cause for a Mass in a Reconstructed Breast. ( 27579225 )
2016
38
Calcinosis in juvenile dermatomyositis: frequency, risk factors and outcome. ( 27007612 )
2016
39
Calcinosis Clues. ( 27464777 )
2016
40
Scrotal Calcinosis. ( 26921158 )
2016
41
Milia-like calcinosis cutis in a girl with Down syndrome. ( 27828644 )
2016
42
Severe dystrophic calcinosis cutis with tumor-like nodules. ( 26862141 )
2016
43
Intradural tumoral calcinosis of the foramen magnum region: A case report. ( 27728984 )
2016
44
Scrotal calcinosis. ( 27920100 )
2016
45
A case of a generalized symptomatic calcinosis in systemic sclerosis. ( 27833984 )
2016
46
Uremic tumoral calcinosis in the cervical spine: case report. ( 26943247 )
2016
47
Tumoral calcinosis of the cervical spine in a dialysis patient. Case report and review of the literature. ( 28012693 )
2016
48
Calcinosis circumscripta associated with osseous cranial thoracic stenotic myelopathy in a dog. ( 27593196 )
2016
49
Ultrasonographic findings in two sheep with enzootic calcinosis. ( 27934625 )
2016
50
Active subcutaneous calcinosis demonstrated by fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in a case of limited cutaneous systemic sclerosis. ( 27095870 )
2016

Variations for Calcinosis

Expression for Calcinosis

Search GEO for disease gene expression data for Calcinosis.

Pathways for Calcinosis

Pathways related to Calcinosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.42 FGF23 GALNT3 KL
2 10.61 ENPP1 MGP SPP1

GO Terms for Calcinosis

Cellular components related to Calcinosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 AHSG CALCA ENPP1 FGF23 KL MGP
2 extracellular space GO:0005615 9.17 AHSG CALCA ENPP1 FGF23 KL SPARC

Biological processes related to Calcinosis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.72 AHSG ANKH PHEX
2 ossification GO:0001503 9.67 AHSG MGP SPARC
3 cellular protein metabolic process GO:0044267 9.67 AHSG CALCA FGF23 SPP1
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.63 FGF23 GALNT3 KL
5 negative regulation of insulin receptor signaling pathway GO:0046627 9.56 AHSG ENPP1
6 phosphate-containing compound metabolic process GO:0006796 9.54 ENPP1 FGF23
7 response to vitamin D GO:0033280 9.52 PHEX SPP1
8 negative regulation of bone mineralization GO:0030502 9.51 AHSG FGF23
9 cellular response to vitamin D GO:0071305 9.48 FGF23 PHEX
10 cellular phosphate ion homeostasis GO:0030643 9.43 ENPP1 FGF23
11 cellular response to parathyroid hormone stimulus GO:0071374 9.4 FGF23 PHEX
12 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.32 FGF23 KL
13 inorganic diphosphate transport GO:0030505 9.26 ANKH ENPP1
14 response to sodium phosphate GO:1904383 9.16 FGF23 PHEX
15 biomineral tissue development GO:0031214 9.13 ENPP1 PHEX SPP1
16 regulation of bone mineralization GO:0030500 9.02 AHSG ANKH ENPP1 FGF23 MGP

Molecular functions related to Calcinosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.16 SPARC SPP1
2 fibroblast growth factor receptor binding GO:0005104 8.96 FGF23 KL
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 FGF23 KL RGL2

Sources for Calcinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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