Aliases & Classifications for Campylobacteriosis

MalaCards integrated aliases for Campylobacteriosis:

Name: Campylobacteriosis 12 72 3 14
Enteric Campylobacteriosis 69
Campylobacter Infections 41
Campylobacter Infection 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13622
MeSH 41 D002169
SNOMED-CT 64 86500004

Summaries for Campylobacteriosis

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in intestine, has material basis in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has symptom diarrhea or has symptom dysentery, has symptom abdominal cramps and pain, and has symptom fever.

MalaCards based summary : Campylobacteriosis, also known as enteric campylobacteriosis, is related to brucellosis and q fever, and has symptoms including diarrhea or has_symptom dysentery, abdominal cramps and fever. An important gene associated with Campylobacteriosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are IL-2 Pathway and Toll-Like receptor Signaling Pathways. The drugs Rifaximin and rifamycin SV have been mentioned in the context of this disorder. Affiliated tissues include intestine, liver and bone, and related phenotypes are growth/size/body region and cardiovascular system

CDC : 3 Learn more about the multistate outbreak of multidrug-resistant Campylobacter infections linked to pet store puppies

Wikipedia : 72 Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among... more...

Related Diseases for Campylobacteriosis

Diseases related to Campylobacteriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 brucellosis 29.8 IFNG SLC11A1 TLR4
2 q fever 29.6 IFNG IL1B TLR4
3 toxoplasmosis 29.6 IFNG IL1B TLR4
4 chlamydia 29.6 IFNG IL1B TLR4
5 gastrointestinal system disease 29.6 IFNG IL1B TLR4
6 salmonellosis 28.5 IFNG IL1B JUN SLC11A1 STAT1 TLR4
7 inflammatory bowel disease 27.7 IFNG IL1B JUN SLC11A1 STAT1 TLR4
8 prosthetic joint infection 10.4 IL1B TLR4
9 suppurative otitis media 10.4 IL1B TLR4
10 endometrial disease 10.4 IL1B TLR4
11 cysticercosis 10.4 IL1B TLR4
12 scrub typhus 10.3 IL1B TLR4
13 middle ear disease 10.3 IL1B TLR4
14 hemorrhagic cystitis 10.3 JUN TLR4
15 enterobiasis 10.3 SLC11A1 TLR4
16 perinatal necrotizing enterocolitis 10.3 IL1B TLR4
17 spondylosis 10.3 IL1B VDR
18 coccidioidomycosis 10.3 STAT1 TLR4
19 multidrug-resistant tuberculosis 10.3 SLC11A1 VDR
20 variola major 10.2 IFNG TLR4
21 idiopathic hypercalciuria 10.2 IL1B VDR
22 uterine anomalies 10.2 IL1B TLR4
23 staphylococcal toxic shock syndrome 10.2 IFNG IL1B
24 myositis fibrosa 10.2 IFNG TLR4
25 ascaris lumbricoides infection 10.2 IFNG IL1B
26 keratoconjunctivitis sicca 10.2 IL1B TLR4
27 crohn's colitis 10.2 IFNG IL1B
28 central nervous system tuberculosis 10.2 IL1B STAT1
29 central nervous system vasculitis 10.2 IFNG IL1B
30 fascioliasis 10.1 IFNG IL1B
31 bacterial vaginosis 10.1 IL1B TLR4
32 buruli ulcer 10.1 IFNG SLC11A1
33 eales disease 10.1 IFNG IL1B
34 aseptic meningitis 10.1 IFNG IL1B
35 eumycotic mycetoma 10.1 IFNG IL1B
36 aging 10.1
37 hand, foot and mouth disease 10.1 IFNG VDR
38 idiopathic neutropenia 10.1 IL1B TLR4
39 pertussis 10.1 IL1B JUN TLR4
40 glanders 10.1 HCFC1 TLR4
41 trichomoniasis 10.1
42 human t-cell leukemia virus type 2 10.0 IFNG STAT1
43 invasive aspergillosis 10.0 IFNG TLR4
44 histoplasmosis 10.0 IFNG STAT1
45 lepromatous leprosy 10.0 IFNG VDR
46 diarrhea 10.0
47 autoinflammation, lipodystrophy, and dermatosis syndrome 10.0 IFNG IL1B TLR4
48 toxic shock syndrome 10.0 IFNG IL1B TLR4
49 intestinal disease 10.0 IFNG IL1B TLR4
50 respiratory system disease 10.0 IFNG IL1B TLR4

Comorbidity relations with Campylobacteriosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Campylobacteriosis:



Diseases related to Campylobacteriosis

Symptoms & Phenotypes for Campylobacteriosis

Symptoms:

12
  • diarrhea or has_symptom dysentery
  • abdominal cramps
  • fever

UMLS symptoms related to Campylobacteriosis:


pruritus, fever

MGI Mouse Phenotypes related to Campylobacteriosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.98 JUN HCFC1 IFNG STAT1 IL1B TLR4
2 cardiovascular system MP:0005385 9.95 TLR4 JUN IFNG STAT1 IL1B VDR
3 hematopoietic system MP:0005397 9.95 SLC11A1 IFNG STAT1 IL1B TLR4 JUN
4 immune system MP:0005387 9.91 SLC11A1 IFNG STAT1 IL1B TLR4 JUN
5 digestive/alimentary MP:0005381 9.85 SLC11A1 IFNG STAT1 TLR4 VDR
6 integument MP:0010771 9.8 VDR IFNG STAT1 IL1B TLR4 JUN
7 mortality/aging MP:0010768 9.76 VDR HCFC1 SLC11A1 IFNG STAT1 IL1B
8 liver/biliary system MP:0005370 9.65 JUN HCFC1 IFNG STAT1 TLR4
9 neoplasm MP:0002006 9.35 SLC11A1 IFNG STAT1 IL1B TLR4
10 skeleton MP:0005390 9.1 JUN IFNG STAT1 IL1B TLR4 VDR

Drugs & Therapeutics for Campylobacteriosis

Drugs for Campylobacteriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173
2 rifamycin SV Phase 2, Phase 3
3 Rifamycins Phase 2, Phase 3
4 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
5 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Anti-Infective Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9
Aluminum hydroxide Approved, Investigational Phase 2,Phase 1 21645-51-2
10 Vaccines Phase 2,Phase 1
11
Aluminum sulfate Approved Phase 1 10043-01-3
12 Adjuvants, Immunologic Phase 1
13 Antacids Phase 1
14 Anti-Ulcer Agents Phase 1
15
Formaldehyde Approved, Vet_approved 50-00-0 712
16 Ether
17 Disinfectants
18 Antitubercular Agents
19 Cola Nutraceutical

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Efficacy of Rifaximin in Preventing Campylobacteriosis Completed NCT02280044 Phase 2, Phase 3
2 ACE393-103 Vaccination Challenge Study Unknown status NCT00859716 Phase 2
3 Campylobacter Jejuni Challenge Model Development: Dose Ranging Study Unknown status NCT00434798 Phase 1
4 Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection Unknown status NCT01048112 Phase 1
5 Safety Study of a Capsule-Conjugate Vaccine to Prevent Campylobacter-Caused Diarrhea Completed NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
6 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
7 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
8 Mucosal and Microbiota Changes During Acute Campylobacteriosis Recruiting NCT03223077
9 Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders Recruiting NCT03266068
10 Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota Active, not recruiting NCT02040922
11 Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates Terminated NCT02232373

Search NIH Clinical Center for Campylobacteriosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: campylobacter infections

Genetic Tests for Campylobacteriosis

Anatomical Context for Campylobacteriosis

The Foundational Model of Anatomy Ontology organs/tissues related to Campylobacteriosis:

18
Intestine

MalaCards organs/tissues related to Campylobacteriosis:

38
Liver, Bone, Testes

Publications for Campylobacteriosis

Articles related to Campylobacteriosis:

(show top 50) (show all 252)
# Title Authors Year
1
Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice. ( 29408609 )
2018
2
Outbreak of Campylobacteriosis Following a Dairy Farm Visit: Confirmation by Genotyping. ( 28350214 )
2017
3
A systematic review and meta-analysis on the incubation period of Campylobacteriosis. ( 28669361 )
2017
4
Occupational Distribution of Campylobacteriosis and Salmonellosis Cases - Maryland, Ohio, and Virginia, 2014. ( 28817554 )
2017
5
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
6
Occupational Animal Exposure Among Persons with Campylobacteriosis and Cryptosporidiosis - Nebraska, 2005-2015. ( 28910275 )
2017
7
Pet-associated Campylobacteriosis: A persisting public health concern. ( 28834267 )
2017
8
Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. ( 29268955 )
2017
9
MLST genotypes of Campylobacter jejuni isolated from broiler products, dairy cattle and human campylobacteriosis cases in Lithuania. ( 28619013 )
2017
10
Rifaximin fails to prevent campylobacteriosis in the human challenge model: a randomized, double-blind, placebo-controlled trial. ( 29145631 )
2017
11
Source attribution of human campylobacteriosis at the point of exposure by combining comparative exposure assessment and subtype comparison based on comparative genomic fingerprinting. ( 28837643 )
2017
12
Epidemiology of campylobacteriosis in Denmark 2000-2015. ( 28597535 )
2017
13
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
14
The recurrent campylobacteriosis epidemic over Christmas and New Year in European countries, 2006-2014. ( 28693589 )
2017
15
Spatio-temporal outbreaks of campylobacteriosis and the role of fresh-milk vending machines in the Czech Republic: A methodological study. ( 29239559 )
2017
16
Acute Gastroenteritis and Campylobacteriosis in Swiss Primary Care: The Viewpoint of General Practitioners. ( 27603141 )
2016
17
A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health. ( 26679515 )
2016
18
Filling gaps in notification data: a model-based approach applied to travel related campylobacteriosis cases in New Zealand. ( 27600394 )
2016
19
Estimating healthcare costs of acute gastroenteritis and human campylobacteriosis in Switzerland. ( 27513710 )
2016
20
The campylobacteriosis conundrum - examining the incidence of infection with Campylobacter sp. in Australia, 1998-2013. ( 27938447 )
2016
21
Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver PActAc Using PFGE and WGS. ( 27334628 )
2016
22
Campylobacteriosis: the role of poultry meat. ( 26686808 )
2016
23
Campylobacteriosis in Poland in 2013 and 2014 ( 27779836 )
2016
24
Factors associated with increasing campylobacteriosis incidence in Michigan, 2004-2013. ( 27488877 )
2016
25
Association between community socioeconomic factors, animal feeding operations, and campylobacteriosis incidence rates: Foodborne Diseases Active Surveillance Network (FoodNet), 2004-2010. ( 27450432 )
2016
26
Outbreak of Campylobacteriosis Associated with Raccoon Contact at a Wildlife Rehabilitation Centre, Minnesota, 2013. ( 27576067 )
2016
27
Combining QMRA and Epidemiology to Estimate Campylobacteriosis Incidence. ( 26889674 )
2016
28
Non food-related risk factors of campylobacteriosis in Canada: a matched case-control study. ( 27677338 )
2016
29
Campylobacteriosis in the South Bohemian RegionA - aA Recurrent Problem. ( 27690477 )
2016
30
Human Campylobacteriosis in Luxembourg, 2010-2013: A Case-Control Study Combined with Multilocus Sequence Typing for Source Attribution and Risk Factor Analysis. ( 26860258 )
2016
31
Trends in the Epidemiology of Campylobacteriosis in Israel (1999-2012). ( 27203409 )
2016
32
Extreme precipitation events and increased risk of campylobacteriosis in Maryland, U.S.A. ( 27214137 )
2016
33
Using geovisual analytics in Google Earth to understand disease distribution: a case study of campylobacteriosis in the Czech Republic (2008-2012). ( 25628063 )
2015
34
Temporal patterns of Campylobacter contamination on chicken and their relationship to campylobacteriosis cases in the United States. ( 26065728 )
2015
35
Effect of Antimicrobial Use in Agricultural Animals on Drug-resistant Foodborne Campylobacteriosis in Humans: A Systematic Literature Review. ( 26580432 )
2015
36
Seasonality of Campylobacter jejuni isolates associated with human campylobacteriosis in the Manawatu region, New Zealand. ( 26344515 )
2015
37
Community Incidence of Campylobacteriosis and Nontyphoidal Salmonellosis, France, 2008-2013. ( 26193045 )
2015
38
Calling all Campy - how routine investigation and molecular characterization impacts the understanding of campylobacteriosis epidemiology - Alaska, United States, 2004-2013. ( 26119636 )
2015
39
Human campylobacteriosis related to the consumption of raw milk sold by vending machines in Italy: Quantitative risk assessment based on official controls over four years. ( 26142145 )
2015
40
Notes from the field: campylobacteriosis outbreak associated with consuming undercooked chicken liver pActAc - ohio and Oregon, december 2013-january 2014. ( 25879900 )
2015
41
Prevalence and risk factors associated with bovine genital campylobacteriosis and bovine trichomonosis in the state of Pernambuco, Brazil. ( 25633914 )
2015
42
Brucellosis, genital campylobacteriosis and other factors affecting calving rate of cattle in three states of Northern Nigeria. ( 25601264 )
2015
43
A waterborne outbreak of campylobacteriosis in the South Island of New Zealand due to a failure to implement a multi-barrier approach. ( 25252359 )
2014
44
Campylobacteriosis outbreak associated with consumption of undercooked chicken liver pActAc in the East of England, September 2011: identification of a dose-response risk. ( 23711104 )
2014
45
Campylobacteriosis - an overview. ( 24584395 )
2014
46
Potential association between the recent increase in campylobacteriosis incidence in the Netherlands and proton-pump inhibitor use - an ecological study. ( 25139075 )
2014
47
Seroprevalence of campylobacteriosis and relevant post-infectious sequelae. ( 24413899 )
2014
48
Determining the health benefits of poultry industry compliance measures: the case of campylobacteriosis regulation in New Zealand. ( 24732250 )
2014
49
The association between campylobacteriosis, agriculture and drinking water: a case-case study in a region of British Columbia, Canada, 2005-2009. ( 24892423 )
2014
50
Estimated community costs of an outbreak of campylobacteriosis resulting from contamination of a public water supply in Darfield, New Zealand. ( 24732249 )
2014

Variations for Campylobacteriosis

Expression for Campylobacteriosis

Search GEO for disease gene expression data for Campylobacteriosis.

Pathways for Campylobacteriosis

Pathways related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 IFNG IL1B JUN STAT1 TLR4
2
Show member pathways
12.82 IL1B JUN STAT1 TLR4
3
Show member pathways
12.57 HCFC1 IFNG IL1B JUN STAT1 TLR4
4
Show member pathways
12.54 IFNG IL1B JUN STAT1
5
Show member pathways
12.46 IFNG IL1B JUN STAT1 TLR4
6
Show member pathways
12.38 IFNG IL1B JUN STAT1 TLR4
7
Show member pathways
12.29 IFNG IL1B JUN
8
Show member pathways
12.21 JUN STAT1 TLR4
9
Show member pathways
12.2 IFNG IL1B JUN
10
Show member pathways
12.11 IFNG IL1B STAT1 TLR4
11 12.06 IFNG STAT1 TLR4
12
Show member pathways
12.04 IFNG IL1B STAT1
13
Show member pathways
12.04 IFNG IL1B JUN STAT1 TLR4
14 11.98 IFNG IL1B JUN
15 11.97 IFNG IL1B STAT1 TLR4 VDR
16
Show member pathways
11.96 IFNG JUN STAT1
17 11.96 IFNG IL1B JUN STAT1
18
Show member pathways
11.95 IFNG IL1B JUN STAT1 TLR4
19
Show member pathways
11.93 IL1B JUN STAT1 TLR4
20 11.91 IFNG IL1B TLR4
21
Show member pathways
11.86 IFNG IL1B JUN STAT1
22 11.84 IFNG IL1B JUN
23 11.8 IL1B JUN STAT1
24 11.79 IFNG IL1B TLR4
25
Show member pathways
11.77 IFNG IL1B JUN STAT1 TLR4
26
Show member pathways
11.76 IFNG IL1B STAT1
27
Show member pathways
11.74 IFNG IL1B STAT1 TLR4
28 11.71 IFNG JUN STAT1
29 11.71 IFNG IL1B JUN TLR4
30 11.67 IL1B JUN TLR4
31 11.67 IFNG IL1B JUN TLR4
32
Show member pathways
11.59 IFNG IL1B JUN
33 11.54 IFNG JUN STAT1
34 11.46 IFNG IL1B TLR4
35 11.45 IFNG IL1B JUN
36 11.44 IFNG IL1B TLR4
37 11.3 IFNG IL1B STAT1
38 11.25 IFNG IL1B
39 11.24 IL1B TLR4
40 11.2 IFNG IL1B
41 11.16 IFNG IL1B
42 11.13 IFNG JUN
43 11.1 IFNG JUN
44 11.08 IFNG IL1B
45 11.07 IFNG JUN
46
Show member pathways
11.04 IFNG IL1B JUN STAT1 TLR4
47 11.01 IFNG JUN
48 10.91 IFNG IL1B JUN VDR
49 10.73 JUN TLR4

GO Terms for Campylobacteriosis

Biological processes related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 HCFC1 IFNG STAT1 VDR
2 positive regulation of cell proliferation GO:0008284 9.85 IFNG IL1B JUN STAT1
3 immune response GO:0006955 9.84 IFNG IL1B SLC11A1 TLR4
4 response to lipopolysaccharide GO:0032496 9.62 IL1B JUN SLC11A1 TLR4
5 positive regulation of epithelial cell migration GO:0010634 9.61 IFNG JUN
6 response to bacterium GO:0009617 9.6 SLC11A1 TLR4
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.59 IL1B TLR4
8 positive regulation of phagocytosis GO:0050766 9.58 IL1B SLC11A1
9 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TLR4
10 cellular response to organic cyclic compound GO:0071407 9.58 HCFC1 IL1B STAT1
11 positive regulation of interleukin-12 production GO:0032735 9.57 IFNG TLR4
12 positive regulation of NF-kappaB import into nucleus GO:0042346 9.56 IL1B TLR4
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 IFNG IL1B
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 STAT1 TLR4
15 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 HCFC1 IL1B JUN SLC11A1 STAT1 TLR4
16 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 IFNG STAT1
17 positive regulation of interferon-alpha production GO:0032727 9.48 STAT1 TLR4
18 negative regulation of interleukin-17 production GO:0032700 9.46 IFNG TLR4
19 macrophage activation GO:0042116 9.43 SLC11A1 TLR4
20 positive regulation of interferon-gamma production GO:0032729 9.43 IL1B SLC11A1 TLR4
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG IL1B
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 IFNG IL1B TLR4
23 positive regulation of gene expression GO:0010628 9.1 HCFC1 IFNG IL1B SLC11A1 TLR4 VDR

Molecular functions related to Campylobacteriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activating transcription factor binding GO:0033613 8.62 HCFC1 JUN

Sources for Campylobacteriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....