MCID: CNC007
MIFTS: 27

Cancer Progression/metastasis malady

Cancer diseases category

Summaries for Cancer Progression/metastasis

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32MalaCards
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MalaCards: Cancer Progression/metastasis is related to prostatitis and pancreatitis. An important gene associated with Cancer Progression/metastasis is FGFR4 (fibroblast growth factor receptor 4), and among its related pathways are Transcription Androgen Receptor nuclear signaling and MicroRNAs in cancer. The compounds estrogen and phosphotyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and cellular.

Aliases & Classifications for Cancer Progression/metastasis

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

cancer progression/metastasis 46


Related Diseases for Cancer Progression/metastasis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cancer Progression/metastasis:



Diseases related to cancer progression/metastasis

Clinical Features for Cancer Progression/metastasis

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Drugs & Therapeutics for Cancer Progression/metastasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cancer Progression/metastasis

Drug clinical trials:

Search ClinicalTrials for Cancer Progression/metastasis

Search NIH Clinical Center for Cancer Progression/metastasis

Search CenterWatch for Cancer Progression/metastasis

Genetic Tests for Cancer Progression/metastasis

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Anatomical Context for Cancer Progression/metastasis

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Animal Models for Cancer Progression/metastasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cancer Progression/metastasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.4FOXM1, SHC1, EPB41L3, EPHB2, HPN, IL6
2MP:00053848.6EPHB2, IL6, FGFR4, EPB41L3, SHC1, MTA2
3MP:00053788.6SPG7, KLF6, TKTL1, IL6, FGFR4, EZR

Publications for Cancer Progression/metastasis

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Genetic Variations for Cancer Progression/metastasis

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Expression for genes affiliated with Cancer Progression/metastasis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cancer Progression/metastasis

Search GEO for disease gene expression data for Cancer Progression/metastasis.

Pathways for genes affiliated with Cancer Progression/metastasis

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Sources:
12EMD Millipore, 29KEGG
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Pathways related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Androgen Receptor nuclear signaling
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10.0IL6, EZR, SHC1
29.6FSCN1, EZR, MIR203, SHC1, RDX

Compounds for genes affiliated with Cancer Progression/metastasis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen4410.4MTA2
2phosphotyrosine449.9RDX, SHC1, EZR, FGFR4
3cytochalasin d44 5910.9EZR, SHC1, LCP1
412-o-tetradecanoylphorbol 13-acetate449.7FOXM1, SHC1, EZR, FSCN1
5paraffin449.5MAGEA3, EZR, FGFR4, FSCN1
6serine449.3KLF6, LCP1, RDX, SHC1, EPHB2, HPN
7tyrosine449.3RDX, MTA1, SHC1, EPHB2, EZR, FGFR4
8calcium44 49 11 2412.0LCP1, RDX, SHC1, EPHB2, EZR, FSCN1

GO Terms for genes affiliated with Cancer Progression/metastasis

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Sources:
16Gene Ontology
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Cellular components related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic to membraneGO:01989810.1RDX, EPB41L3, EZR
2NuRD complexGO:01658110.0MTA1, MTA2
3filopodiumGO:03017510.0RDX, EZR, FSCN1
4cell-cell junctionGO:0059119.7FGFR4, HPN, EPB41L3
5nucleolusGO:0057309.1RRP1B, MTA1, FGFR4, FOXM1, EZR, LIN28B

Biological processes related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletal anchoring at plasma membraneGO:00701610.1EZR, EPB41L3
2actin filament bundle assemblyGO:0510179.8FSCN1, EZR, LCP1
3regulation of cell shapeGO:0083609.6IL6, EZR, HPN, EPB41L3

Molecular functions related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II repressing transcription factor bindingGO:00110310.0MTA2, MTA1
2protein tyrosine kinase activityGO:0047139.9SHC1, EPHB2, FGFR4
3actin filament bindingGO:0510159.9FSCN1, EZR, LCP1
4actin bindingGO:0037799.4FSCN1, EPB41L3, RDX, LCP1
5protein bindingGO:0055158.2SPG7, FOXM1, RDX, MTA1, MTA2, SHC1

Products for genes affiliated with Cancer Progression/metastasis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Cancer Progression/metastasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet