Cancer Progression/metastasis malady

MalaCards: Cancer Progression/metastasis, also known as cancer progression, is related to breast cancer and prostate cancer, progression of. An important gene associated with Cancer Progression/metastasis is EPHB2 (EPH receptor B2), and among its related pathways are Development FGF-family signaling and Transcription_Sin3 and NuRD in transcription regulation. The compounds pd 161570 and threonine have been mentioned in the context of this disorder. Affiliated tissues include breast and prostate, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

cancer progression/metastasis 33 cancer progression 43

Diseases related to cancer progression/metastasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 220)

id	Related Disease	Score	Top Affiliating Genes
1	breast cancer	33.4	MMP2, MMP9, FGFR2, IL6, TGFB1, STK11
2	prostate cancer, progression of	32.7	KLF6, RDX, LGALS3, MTA1, MMP2, MMP9
3	prostate cancer, progression and metastasis of	30.6	KLF6, RDX, IL6, EZR, HPN, EPB41L3
4	prostatitis	28.8	KLF6, RDX, LGALS3, LCP1, MTA1, FSCN1
5	cervical cancer	27.8	MMP2, MMP9, FN1, FGFR2, IL6, HPN
6	oral cancer	26.7	MMP2, MMP9, FN1, IL6, TGFB1
7	colorectal cancer	26.5	KLF6, LGALS3, LCP1, MTA1, FSCN1, MMP2
8	pancreatic cancer	26.4	KLF6, RDX, LGALS3, MTA1, FSCN1, MMP2
9	gastric cancer	26.4	KLF6, LGALS3, FSCN1, MMP2, MMP9, FN1
10	renal cell carcinoma	26.3	FSCN1, MMP2, MMP9, FGFR2, EZR, HPN
11	urinary bladder cancer	26.3	LCP1, MMP2, MMP9, FN1, TGFB1
12	cervicitis	26.1	LGALS3, MTA1, FSCN1, MMP2, MMP9, FN1
13	colon cancer	25.6	KLF6, LGALS3, LCP1, MTA1, FSCN1, MMP2
14	hypoxia	25.5	LGALS3, MTA1, MMP2, MMP9, FN1, IL6
15	retinoblastoma	25.4	KLF6, LCP1, MMP2, MMP9, FGFR2, IL6
16	pancreatitis	25.3	KLF6, RDX, LGALS3, MTA1, FSCN1, MMP2
17	epithelial ovarian cancer	25.3	MMP2, MMP9, FN1, FGFR2, IL6, TGFB1
18	thyroid cancer	25.0	LGALS3, MMP2, MMP9, FN1, FGFR2, FGFR4
19	laryngeal cancer	25.0	LGALS3, MMP2, MMP9, TGFB1
20	lung adenocarcinoma	24.7	KLF6, MMP2, MMP9, FGFR4, TGFB1, STK11
21	polyposis	24.6	KLF6, MMP2, MMP9, IL6, TGFB1, STK11
22	colon adenocarcinoma	24.5	LGALS3, FSCN1, MMP2, MMP9, EZR, TGFB1
23	ovarian cancer	24.5	KLF6, LCP1, MTA1, MTA3, FSCN1, MMP2
24	skin cancer	24.4	LGALS3, MMP2, MMP9, FGFR2, SHC1
25	nasopharyngitis	24.1	KLF6, LCP1, FSCN1, MMP2, MMP9, IL6
26	esophageal cancer	24.0	MTA1, MMP2, MMP9, FGFR2, IL6, MAGEA3
27	esophagitis	23.7	KLF6, LGALS3, MTA1, FSCN1, MMP2, MMP9
28	esophageal squamous cell carcinoma	23.7	LGALS3, MTA1, FSCN1, MMP2, MMP9, IL6
29	adenoma	23.6	LGALS3, FSCN1, MMP2, MMP9, FN1, FGFR2
30	laryngitis	23.1	LGALS3, MTA1, FSCN1, MMP2, MMP9, FN1
31	thyroiditis	22.8	LGALS3, FSCN1, MMP2, MMP9, FN1, FGFR2
32	carcinoma	22.6	KLF6, RDX, LGALS3, LCP1, MTA2, MTA1
33	adenocarcinoma	22.2	KLF6, RDX, LGALS3, MTA1, MTA3, FSCN1
34	melanoma	21.5	KLF6, LGALS3, LCP1, MTA1, FSCN1, MMP2
35	squamous cell carcinoma	21.0	KLF6, LGALS3, MTA1, FSCN1, MMP2, MMP9
36	breast carcinoma	20.6	RDX, LGALS3, LCP1, MTA1, FSCN1, MMP2
37	leukemia	19.6	KLF6, LGALS3, LCP1, MMP2, MMP9, FN1
38	castleman's disease	13.5	FSCN1, IL6
39	bile duct cancer	13.4	FSCN1, IL6, MAGEA3
40	mesangial proliferative glomerulonephritis	13.2	FN1, IL6
41	brain cancer	13.2	KLF6, MAGEA3, EZR, EPB41L3, EPHB2
42	hip dysplasia	13.1	IL6, TGFB1
43	achondroplasia	13.0	FGFR2, FGFR4, TKTL1
44	neuroma	13.0	RDX, IL6, EZR, TGFB1
45	proliferative glomerulonephritis	13.0	IL6, SPG7, TGFB1
46	diastrophic dysplasia	13.0	FN1, IL6, TGFB1
47	intraocular melanoma	12.9	MMP2, MAGEA3, EZR
48	neurofibromatosis	12.8	RDX, IL6, EZR, TGFB1, EPB41L3
49	pneumoconiosis	12.8	FN1, IL6, TGFB1
50	non-small cell lung carcinoma	12.7	LGALS3, FN1, STK11, EPB41L3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cancer progression/metastasis:

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MGI Mouse Phenotypes related to cancer progression/metastasis:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.9	GLI2
2	endocrine/exocrine gland phenotype	MP:0005379	9.0	MKL1, FGFR2, GLI2, EPB41L3, SHC1
3	integument phenotype	MP:0010771	8.5	STK11, SHC1, GLI2, FGFR2, MKL1, MTA2
4	immune system phenotype	MP:0005387	8.0	SHC1, IL6, FGFR2, FN1, LGALS3, MTA2
5	mortality/aging	MP:0010768	7.5	EPB41L3, STK11, SHC1, GLI2, EZR, IL6
6	renal/urinary system phenotype	MP:0005367	7.3	LGALS3, EPHB2, STK11, TGFB1, IL6, FGFR2
7	digestive/alimentary phenotype	MP:0005381	7.2	EZR, TGFB1, GLI2, EPHB2, LGALS3, MMP9
8	skeleton phenotype	MP:0005390	7.0	FGFR2, LGALS3, MMP2, MMP9, FN1, IL6
9	vision/eye phenotype	MP:0005391	7.0	MTA1, MMP9, FGFR2, IL6, GLI2, TGFB1
10	reproductive system phenotype	MP:0005389	7.0	KLF6, IL6, EPB41L3, TGFB1, SHC1, GLI2
11	hematopoietic system phenotype	MP:0005397	6.6	LGALS3, MTA2, MMP9, FN1, FGFR2, IL6
12	tumorigenesis	MP:0002006	6.6	EPB41L3, FGFR4, FGFR2, MMP2, MMP9, FN1
13	behavior/neurological phenotype	MP:0005386	6.5	EPB41L3, MMP9, EPHB2, TGFB1, SHC1, SPG7
14	muscle phenotype	MP:0005369	6.2	STK11, FGFR2, TGFB1, SHC1, GLI2, IL6
15	cardiovascular system phenotype	MP:0005385	5.9	SHC1, STK11, IL6, KLF6, LGALS3, MMP2
16	cellular phenotype	MP:0005384	5.2	MMP9, FSCN1, MTA1, FGFR2, MTA2, LGALS3
17	nervous system phenotype	MP:0003631	5.1	FN1, FGFR2, IL6, GLI2, HPN, SPG7
18	growth/size phenotype	MP:0005378	5.1	TGFB1, FN1, EPHB2, FGFR2, FGFR4, STK11
19	homeostasis/metabolism phenotype	MP:0005376	5.0	LGALS3, STK11, SHC1, MTA2, RDX, MMP2

Articles related to cancer progression/metastasis:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	TGF-I^/SMAD/GLI2 signaling axis in cancer progression and metastasis. (21862631)	Javelaud D.... Mauviel A.	2011	TGFB1, GLI2
2	Transketolase-like 1 expression is modulated during c olorectal cancer progression and metastasis formation. (21980427)	Diaz-Moralli S.... Cascante M.	2011	TKTL1
3	Megakaryoblastic leukemia protein-1 (MKL1): Increasin g evidence for an involvement in cancer progression and metastasis. (20816842)	Scharenberg M.A.... Asparuhova M.B.	2010	MKL1
4	p66Shc--a longevity redox protein in human prostate c ancer progression and metastasis : p66Shc in cancer progression and metastasis. (20111892)	Rajendran M.... Lin M.F.	2010	SHC1
5	KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. (18596922)	Narla G.... Martignetti J.A.	2008	KLF6
6	The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. (18829569)	Liu W.... Ezzat S.	2008	FGFR2, FN1, MAGEA3
7	Protein 4.1B suppresses prostate cancer progression and metastasis. (17640904)	Wong S.Y.... Hynes R.O.	2007	RDX, EZR, EPB41L3
8	Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. (18081427)	Crawford N.P.... Hunter K.W.	2007	RRP1B
9	Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. (16533771)	Zhang H.... Kumar R.	2006	MTA1, SPG7, MTA2
10	Hepsin promotes prostate cancer progression and metastasis. (15324701)	Klezovitch O.... Vasioukhin V.	2004	HPN
11	The role of gelatinases in colorectal cancer progression and metastasis. (15588763)	Mook O.R.... Van Noorden C.J.	2004	MMP2, MMP9
12	Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis. (11735128)	Otsuka M.... Seki N.	2001	LCP1, FSCN1, RPS23
13	Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. (11744478)	Shariat S.F.... Slawin K.M.	2001	IL6
14	Involvement of galectin-3 expression in colorectal cancer progression and metastasis. (10375607)	Nakamura M.... Yasutomi M.	1999	LGALS3

Genes related to cancer progression/metastasis according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	EPHB2	EPH receptor B2	11.0
2	HPN	hepsin	11.0	Publications
3	KLF6	Kruppel-like factor 6	11.0	Publications
4	EZR	ezrin	11.0	Publications
5	RDX	radixin	11.0	Publications
6	EPB41L3	erythrocyte membrane protein band 4.1-like 3	11.0	Publications
7	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
8	RPS23	ribosomal protein S23	11.0	Publications
9	RRP1B	ribosomal RNA processing 1 homolog B (S. cerevisiae)	11.0	Publications
10	TKTL1	transketolase-like 1	11.0	Publications
11	MAGEA3	melanoma antigen family A, 3	11.0	Publications
12	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
13	MTA2	metastasis associated 1 family, member 2	11.0	Publications
14	MTA3	metastasis associated 1 family, member 3	11.0	Publications
15	SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	11.0	Publications
16	STK11	serine/threonine kinase 11	11.0
17	MTA1	metastasis associated 1	11.0	Publications
18	FGFR4	fibroblast growth factor receptor 4	11.0
19	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	11.0	Publications
20	GLI2	GLI family zinc finger 2	11.0	Publications
21	SHC1	SHC (Src homology 2 domain containing) transforming protein 1	11.0	Publications
22	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
23	MKL1	megakaryoblastic leukemia (translocation) 1	11.0	Publications
24	FN1	fibronectin 1	11.0	Publications
25	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
26	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
27	TGFB1	transforming growth factor, beta 1	11.0	Publications
28	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications

Pathways related to cancer progression/metastasis according to GeneDecks:

(show all 34)

id	Pathway	Score	Top Affiliating Genes
1	Development FGF-family signaling10	10.0	SHC1, FGFR2
2	Transcription_Sin3 and NuRD in transcription regulation41	9.9	MTA3, MTA1, MTA2
3	Paxillin Interactions36	9.9	FGFR2, EPHB2, FGFR4
4	Ras Pathway36	9.9	FGFR2, FGFR4, EPHB2
5	Transcription Sin3 and NuRD in transcription regulation10	9.8	MTA3, MTA1, MTA2
6	PTEN Pathway36	9.5	FGFR2, FGFR4, FN1
7	Development_FGF-family signaling41	9.4	SHC1, FGFR4, FGFR2
8	Regulation of actin cytoskeleton20	9.3	EZR, FGFR4, RDX, FN1, FGFR2
9	Cell adhesion ECM remodeling10	9.1	EZR, MMP9, MMP2, FN1
10	Cell adhesion_ECM remodeling41	9.1	FN1, MMP9, MMP2, EZR
11	14-3-3 Induced Intracellular Signaling36	9.1	FGFR4, FGFR2, TGFB1, EPHB2
12	Apoptotic Pathways in Synovial Fibroblasts36	9.0	FGFR4, FGFR2, IL6, TGFB1
13	Nanog in Mammalian ESC Pluripotency36	8.9	EPHB2, TGFB1, IL6, FGFR2, FGFR4
14	p53 Mediated Apoptosis36	8.9	IL6, FGFR4, FGFR2, TGFB1
15	Metalloproteases in connective tissue degradation10	8.9	MMP9, MMP2, FN1
16	eNOS Signaling36	8.9	FGFR2, EPHB2, FGFR4, TGFB1, IL6
17	NFAT in Immune Response36	8.8	EPHB2, TGFB1, IL6, FGFR4, FGFR2
18	JNK Pathway36	8.8	IL6, FGFR2, TGFB1, FGFR4
19	Estrogen Pathway36	8.8	FGFR4, EPHB2, IL6, TGFB1, FGFR2
20	GPCR Pathway36	8.8	FGFR2, FGFR4, TGFB1, EPHB2, IL6
21	GSK3 Signaling36	8.8	TGFB1, IL6, FGFR4, FGFR2, EPHB2
22	Transcription_Androgen Receptor nuclear signaling41	8.8	MMP2, EZR, SHC1, IL6, TGFB1
23	Transcription Androgen Receptor nuclear signaling10	8.8	TGFB1, MMP2, EZR, SHC1, IL6
24	Colorectal Cancer Metastasis36	8.6	MMP2, TGFB1, IL6, MMP9
25	Glioma Invasiveness36	8.4	MMP2, MMP9, IL6, TGFB1
26	ILK Signaling36	8.4	FN1, FGFR2, FGFR4, IL6, TGFB1, EPHB2
27	MAPK Signaling36	8.4	FGFR4, FGFR2, FN1, EPHB2, TGFB1, IL6
28	Telomerase Components in Cell Signaling36	8.4	TGFB1, IL6, FGFR4, FGFR2
29	Rho Family GTPases36	8.3	IL6, RDX, TGFB1, FN1, FGFR4, EPHB2
30	Molecular Mechanisms of Cancer36	8.1	EPHB2, STK11, TGFB1, IL6, FGFR4, FGFR2
31	Angiogenesis3	8.1	MMP2, MMP9, FGFR4, TGFB1, FGFR2
32	Pathways in cancer20	8.1	MMP2, TGFB1, GLI2, FGFR2, MMP9
33	ERK Signaling36	8.0	EPHB2, TGFB1, IL6, FGFR4, FN1, FGFR2
34	Pancreatic Adenocarcinoma36	7.8	TGFB1, MMP9, FGFR2, IL6, MMP2, FGFR4

Compounds related to cancer progression/metastasis according to GeneDecks:

(show top 50)    (show all 60)

id	Compound	Score	Top Affiliating Genes
1	pd 16157042	9.9	FGFR4, FGFR2
2	threonine32	9.9	SHC1, FGFR2, RDX
3	su 540242	9.7	FGFR4, FGFR2
4	cgs-27023a32	9.6	MMP2, MMP9
5	flavanol32	9.6	MMP9, MMP2
6	tgf beta132	9.6	MMP2, FN1, IL6
7	col 332	9.5	MMP2, MMP9
8	methyl selenol32	9.5	MMP2, MMP9
9	zoledronic acid32	9.4	IL6, MMP2, MMP9
10	pmma32	9.4	TGFB1, IL6, FN1
11	ns 39832 42	10.4	TGFB1
12	pioglitazone32 9 9	11.2	FN1, MMP9, MMP2
13	ciglitazone32	9.2	MMP9, IL6, MMP2
14	aprotinin32 9 9	11.2	FN1, MMP9, MMP2
15	8-isoprostane32	9.1	IL6, MMP9, MMP2
16	phosphotyrosine32	9.0	FN1, FGFR4, EZR, SHC1, FGFR2, RDX
17	agar32	9.0	LGALS3, FGFR2, FN1, HPN, SHC1
18	tranilast32	8.9	MMP2, MMP9, TGFB1
19	phorbol32	8.8	MMP9, FN1, SHC1, MMP2
20	herbimycin a32 42	9.7	MMP2, IL6, MMP9, FN1, SHC1
21	pdtc32	8.7	TGFB1, MMP2, IL6, MMP9
22	n acetylcysteine32	8.5	MMP9, MMP2, SHC1, FGFR2, IL6
23	rosiglitazone32 9 18 9	11.4	MMP9, MMP2, IL6, TGFB1
24	erythromycin32 9 9	10.4	MMP9, MMP2, FGFR2, TGFB1
25	wortmannin32 42	9.4	SHC1, EZR, FN1, LGALS3, MMP2, MMP9
26	troglitazone32 42 9 9	11.3	MMP9, FN1, IL6, TGFB1, MMP2
27	proline32	8.3	LGALS3, MMP2, MMP9, FGFR2, EZR, SHC1
28	vitamin d32	8.3	SPG7, IL6, FN1, LGALS3, TGFB1, FGFR2
29	progesterone32 42 9 18 9	12.2	EPB41L3, SHC1, MTA1, MMP2, LCP1, LGALS3
30	thymidine32 18	9.1	FGFR2, EPB41L3, SHC1, IL6, FN1, TGFB1
31	sb 20358032 42	9.1	MMP9, FN1, IL6, TGFB1, EPHB2, MMP2
32	ribonucleic acid32	8.1	MMP9, MMP2, TGFB1, FGFR2, KLF6
33	genistein32 9 18 9	11.1	FN1, MMP9, FGFR2, IL6, EZR, SHC1
34	hyaluronic acid32 18	9.0	MMP2, MMP9, FN1, IL6, RDX, EZR
35	ly29400232	8.0	MMP2, MMP9, IL6, FN1, SHC1, TGFB1
36	lactate32	7.8	IL6, TGFB1, MMP9, FN1, MMP2, LGALS3
37	12-o-tetradecanoylphorbol 13-acetate32	7.7	MMP9, FGFR2, FSCN1, EZR, SHC1, TGFB1
38	cytochalasin d32 42	8.7	EZR, LCP1, MMP2, MMP9, SHC1, FN1
39	creatinine32	7.6	IL6, MMP2, MMP9, FN1, SPG7, TGFB1
40	matrigel32	7.6	TGFB1, SHC1, FN1, MMP9, LGALS3, EZR
41	phosphatidylinositol32	7.3	RDX, LGALS3, MMP2, MMP9, FN1, FGFR2
42	pd 98,05932	7.3	MMP2, TGFB1, SHC1, IL6, FGFR2, FN1
43	alanine32	7.2	IL6, FN1, MMP2, EZR, STK11, SHC1
44	calcium32 9 18 9	9.8	EZR, RDX, MMP9, MMP2, FSCN1, LCP1
45	retinoic acid32 42 18	8.7	IL6, FGFR2, FN1, MMP9, MMP2, FSCN1
46	tyrosine32	6.7	LGALS3, EZR, MMP9, FGFR2, FGFR4, IL6
47	vegf32	6.5	LGALS3, STK11, TGFB1, SHC1, IL6, FGFR4
48	paraffin32	6.5	MMP2, MMP9, FN1, FGFR2, FGFR4, MAGEA3
49	serine32	5.7	MMP9, STK11, TGFB1, SHC1, HPN, EZR
50	estrogen32	5.6	KLF6, TGFB1, SHC1, EZR, IL6, FGFR2

Cellular components related to cancer progression/metastasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extrinsic to membrane	GO:019898	9.9	RDX, EZR, EPB41L3
2	filopodium	GO:030175	9.6	RDX, FSCN1, EZR
3	proteinaceous extracellular matrix	GO:005578	7.7	LGALS3, MMP2, MMP9, FN1, TGFB1
4	cytoplasm	GO:005737	6.1	MKL1, KLF6, LGALS3, LCP1, MTA1, MTA3

Biological processes related to cancer progression/metastasis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	actin filament bundle assembly	GO:051017	9.9	FSCN1, LCP1, EZR
2	peptidyl-tyrosine phosphorylation	GO:018108	9.4	FGFR4, FGFR2, EPHB2
3	insulin receptor signaling pathway	GO:008286	9.1	STK11, SHC1, FGFR4, FGFR2
4	organ regeneration	GO:031100	8.7	TGFB1, LCP1, SHC1
5	angiogenesis	GO:001525	8.5	MMP2, FN1, FGFR2, SHC1, EPHB2
6	positive regulation of cell proliferation	GO:008284	8.3	IL6, TGFB1, FGFR4, FGFR2, SHC1
7	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	KLF6, MTA2, MKL1, FGFR2, IL6, GLI2

Molecular functions related to cancer progression/metastasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor-activated receptor activity	GO:005007	9.7	FGFR2, FGFR4
2	protein tyrosine kinase activity	GO:004713	8.9	FGFR4, SHC1, EPHB2, FGFR2
3	protein binding	GO:005515	4.0	EPB41L3, FGFR2, MAGEA3, EZR, GLI2, HPN