MCID: CNC007
MIFTS: 32

Cancer Progression/metastasis malady

Cancer category

Summaries for Cancer Progression/metastasis

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cancer Progression/metastasis is related to pancreatitis and rhabdomyosarcoma. An important gene associated with Cancer Progression/metastasis is FGFR4 (fibroblast growth factor receptor 4), and among its related pathways are Transcription Androgen Receptor nuclear signaling and MicroRNAs in cancer. The compounds estrogen and phosphotyrosine have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and lymph node, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Aliases & Classifications for Cancer Progression/metastasis

Sources:
47OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

cancer progression/metastasis 47


Related Diseases for Cancer Progression/metastasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Cancer Progression/metastasis:



Diseases related to cancer progression/metastasis

Clinical Features for Cancer Progression/metastasis

Drugs & Therapeutics for Cancer Progression/metastasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cancer Progression/metastasis

Drug clinical trials:

Search ClinicalTrials for Cancer Progression/metastasis

Search NIH Clinical Center for Cancer Progression/metastasis

Search CenterWatch for Cancer Progression/metastasis

Genetic Tests for Cancer Progression/metastasis

Anatomical Context for Cancer Progression/metastasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cancer Progression/metastasis:

33
Liver, Tongue, Lymph node, Lung, Colon, Breast, Prostate

Animal Models for Cancer Progression/metastasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cancer Progression/metastasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.4FOXM1, SHC1, EPB41L3, EPHB2, HPN, IL6
2MP:00053848.6EPHB2, IL6, FGFR4, EPB41L3, SHC1, MTA2
3MP:00053788.6SPG7, KLF6, TKTL1, IL6, FGFR4, EZR

Publications for Cancer Progression/metastasis

Sources:
51PubMed
See all sources

Articles related to Cancer Progression/metastasis:

(show top 50)    (show all 83)
idTitleAuthorsYear
1
Prolyl-4-hydroxylase I+ subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. (24383403)
2014
2
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer. (24402692)
2014
3
FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk. (22733437)
2013
4
Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer. (24222325)
2013
5
The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis. (23136192)
2013
6
The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer. (23519840)
2013
7
Slow progression of calcified cerebellar metastasis from ovarian cancer: a case report and review of the literature. (24077275)
2013
8
Increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer. (22952619)
2012
9
Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence. (22659453)
2012
10
Metastasis-associated protein 1 nuclear expression is closely associated with tumor progression and angiogenesis in patients with esophageal squamous cell cancer. (22270988)
2012
11
Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. (22617157)
2012
12
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. (21980427)
2011
13
Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis. (21821008)
2011
14
Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. (21159887)
2011
15
Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer. (20661085)
2010
16
RGS16 and FosB underexpressed in pancreatic cancer with lymph node metastasis promote tumor progression. (20571966)
2010
17
p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis. (20111892)
2010
18
MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis. (20461754)
2010
19
Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. (20806969)
2010
20
Tumor-stroma co-evolution in prostate cancer progression and metastasis. (19948237)
2010
21
Megakaryoblastic leukemia protein-1 (MKL1): Increasing evidence for an involvement in cancer progression and metastasis. (20816842)
2010
22
Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis. (19048396)
2009
23
Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. (18561248)
2008
24
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. (18596922)
2008
25
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer. (18567796)
2008
26
Prognostic value of Her-2/neu and DNA index for progression, metastasis and prostate cancer-specific death in men with long-term follow-up after radical prostatectomy. (18767043)
2008
27
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. (18064531)
2008
28
Overexpression of c-Myc and Bcl-2 during progression and distant metastasis of hormone-treated breast cancer. (17046747)
2007
29
MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis. (16996781)
2007
30
Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis. (17264329)
2007
31
Protein 4.1B suppresses prostate cancer progression and metastasis. (17640904)
2007
32
Urokinase-receptor (u-PAR): an essential player in multiple games of cancer: a review on its role in tumor progression, invasion, metastasis, proliferation/dormancy, clinical outcome and minimal residual disease. (16931909)
2006
33
Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. (16533771)
2006
34
Effect of antisense hypoxia-inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. (16628086)
2006
35
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer. (16412380)
2006
36
Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression. (15534110)
2004
37
Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. (15375528)
2004
38
The role of metastasis-associated protein 1 in prostate cancer progression. (14871807)
2004
39
KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. (12684410)
2003
40
Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis. (11821468)
2002
41
Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis. (11735128)
2001
42
Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. (11744478)
2001
43
Hypermethylation of the CD44 gene is associated with progression and metastasis of human prostate cancer. (11582589)
2001
44
Suppression of primary tumor growth and the progression to metastasis with p53 adenovirus in human prostate cancer. (10953161)
2000
45
Involvement of galectin-3 expression in colorectal cancer progression and metastasis. (10375607)
1999
46
Cell proliferation in prostate cancer patients with lymph node metastasis: a marker for progression. (10537347)
1999
47
The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. (10533469)
1999
48
Breast cancer metastasis-associated genes: role in tumour progression to the metastatic state. (9513727)
1998
49
Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer. (9331564)
1997
50
Relationship of c-myc amplification to progression of breast cancer from in situ to invasive tumor and lymph node metastasis. (8492318)
1993

Genetic Variations for Cancer Progression/metastasis

Expression for genes affiliated with Cancer Progression/metastasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cancer Progression/metastasis

Search GEO for disease gene expression data for Cancer Progression/metastasis.

Pathways for genes affiliated with Cancer Progression/metastasis

Sources:
12EMD Millipore, 30KEGG
See all sources

Pathways related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Androgen Receptor nuclear signaling
Hide members
10.0IL6, EZR, SHC1
29.6FSCN1, EZR, MIR203, SHC1, RDX

Compounds for genes affiliated with Cancer Progression/metastasis

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen4510.4MTA2
2phosphotyrosine459.9RDX, SHC1, EZR, FGFR4
3cytochalasin d45 6010.9EZR, SHC1, LCP1
412-o-tetradecanoylphorbol 13-acetate459.7FOXM1, SHC1, EZR, FSCN1
5paraffin459.5MAGEA3, EZR, FGFR4, FSCN1
6serine459.3KLF6, LCP1, RDX, SHC1, EPHB2, HPN
7tyrosine459.3RDX, MTA1, SHC1, EPHB2, EZR, FGFR4
8calcium45 50 11 2412.0LCP1, RDX, SHC1, EPHB2, EZR, FSCN1

GO Terms for genes affiliated with Cancer Progression/metastasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic to membraneGO:01989810.1EZR, EPB41L3, RDX
2NuRD complexGO:01658110.0MTA2, MTA1
3filopodiumGO:03017510.0FSCN1, EZR, RDX
4cell-cell junctionGO:0059119.7FGFR4, HPN, EPB41L3
5nucleolusGO:0057309.1FOXM1, MTA1, MTA2, LIN28B, EZR, FGFR4

Biological processes related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletal anchoring at plasma membraneGO:00701610.1EZR, EPB41L3
2actin filament bundle assemblyGO:0510179.8FSCN1, EZR, LCP1
3regulation of cell shapeGO:0083609.6IL6, EZR, HPN, EPB41L3

Molecular functions related to Cancer Progression/metastasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II repressing transcription factor bindingGO:00110310.0MTA2, MTA1
2protein tyrosine kinase activityGO:0047139.9SHC1, EPHB2, FGFR4
3actin filament bindingGO:0510159.9FSCN1, EZR, LCP1
4actin bindingGO:0037799.4FSCN1, EPB41L3, RDX, LCP1
5protein bindingGO:0055158.2SPG7, FOXM1, RDX, MTA1, MTA2, SHC1

Products for genes affiliated with Cancer Progression/metastasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cancer Progression/metastasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet