MCID: CND006
MIFTS: 34

Candida Glabrata malady

Categories: Rare diseases

Aliases & Classifications for Candida Glabrata

Aliases & Descriptions for Candida Glabrata:

Name: Candida Glabrata 50

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to candidiasis and vaginitis. An important gene associated with Candida Glabrata is CSF2 (Colony Stimulating Factor 2), and among its related pathways/superpathways are Th2 Differentiation Pathway and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. The drugs Miconazole and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and neutrophil, and related phenotype is mortality/aging.

Wikipedia : 71 Candida glabrata is a haploid yeast of the genus Candida, previously known as Torulopsis glabrata. This... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Related Disease Score Top Affiliating Genes
1 candidiasis 10.3
2 vaginitis 10.3
3 vulvovaginitis 10.2
4 aniseikonia 10.2 CSF2 IFNG
5 subclavian artery aneurysm 10.1 CSF2 IFNG
6 esophagus lymphoma 10.1 CSF2 IFNG
7 hutchinson incisors 10.1 CSF2 IFNG
8 endocarditis 10.1
9 vulvovaginal candidiasis 10.1
10 endophthalmitis 10.1
11 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 CSF2 IFNG
12 chorioamnionitis 10.0
13 otulipenia 10.0 CSF2 IFNG
14 pneumonia 10.0
15 endotheliitis 10.0
16 osteomyelitis 10.0
17 sclerosing cholangitis 9.9 HTN3 SKAP2
18 keratitis 9.9
19 hematopoietic stem cell transplantation 9.9
20 esophagitis 9.9
21 peritonitis 9.9
22 cholecystitis 9.9
23 malignant otitis externa 9.7
24 epidural abscess 9.7
25 orchitis 9.7
26 heart disease 9.7
27 bursitis 9.7
28 arthritis 9.7
29 constrictive pericarditis 9.7
30 thrombophlebitis 9.7
31 chronic granulomatous disease 9.7
32 nephrotic syndrome 9.7
33 denture stomatitis 9.7
34 leukemia 9.7
35 myocarditis 9.7
36 spinal cord injury 9.7
37 neurogenic bladder 9.7
38 aspiration pneumonia 9.7
39 olecranon bursitis 9.7
40 myeloid leukemia 9.7
41 chorioretinitis 9.7
42 infective endocarditis 9.7
43 cystitis 9.7
44 epididymo-orchitis 9.7
45 colitis 9.7
46 histoplasmosis 9.7
47 otitis externa 9.7
48 cutaneous candidiasis 9.7
49 pericarditis 9.7
50 stomatitis 9.7

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 RIF1 SKAP2 SQLE APCS CSF2 DHFR

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1 22916-47-8 4189
2
Fluconazole Approved Phase 4,Phase 1 86386-73-4 3365
3
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
4
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
5
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
6
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
7 Antifungal Agents Phase 4,Phase 1
8 Anti-Infective Agents Phase 4,Phase 1
9 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 1
10 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1
11 Hormone Antagonists Phase 4,Phase 1
12 Hormones Phase 4,Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1
14 Steroid Synthesis Inhibitors Phase 4,Phase 1
15 Echinocandins Phase 4
16 Cytochrome P-450 CYP3A Inhibitors Phase 4
17 Acidophilus Nutraceutical Phase 1
18 Brewer's Yeast Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins Completed NCT00839540 Phase 4
2 Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis Completed NCT00496197 Phase 4
3 Use of Oral Probiotics as an Adjunctive Therapy to Fluconazole in the Treatment of Yeast Vaginitis Unknown status NCT00479947 Phase 1
4 Effect of Saccharomyces Cerevisiae on Vulvo-vaginal Candidiasis Recruiting NCT02859493
5 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Recruiting NCT02581319

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

39
Testes, Colon, Neutrophil, Monocytes, Endothelial, Myeloid, Nk Cells

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 623)
id Title Authors Year
1
Repeated applications of photodynamic therapy on Candida glabrata biofilms formed in acrylic resin polymerized. ( 28091850 )
2017
2
The CgHaa1-Regulon Mediates Response and Tolerance to Acetic Acid Stress in the Human Pathogen Candida glabrata. ( 27815348 )
2017
3
Fungicidal effect of thymoquinone involves generation of oxidative stress in Candida glabrata. ( 28024529 )
2017
4
In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes Echinocandin Resistance in Candida glabrata Isolates. ( 27872063 )
2017
5
Fungal CYP51 Inhibitors VT-1161 and VT-1129 exhibit strong in vitro activity against Candida glabrata and C. krusei isolates clinically resistant to azole and echinocandin antifungal compounds. ( 27956419 )
2016
6
Candida glabrata Pneumonia in a Patient with Chronic Obstructive Pulmonary Disease. ( 27882253 )
2016
7
Time-to-reporting of blood culture positivity and central venous catheter-associated Candida glabrata fungemia in cancer patients. ( 27133559 )
2016
8
Interaction of human fibronectin with Candida glabrata epithelial adhesin 6 (Epa6). ( 27474404 )
2016
9
Two echinocandin-resistant Candida glabrata FKS mutants from South Africa. ( 27069849 )
2016
10
In Vitro Activities of Six Antifungal Drugs Against Candida glabrata Isolates: An Emerging Pathogen. ( 27540459 )
2016
11
Potassium Uptake Mediated by Trk1 Is Crucial for Candida glabrata Growth and Fitness. ( 27058598 )
2016
12
Genome engineering in the yeast pathogen Candida glabrata using the CRISPR-Cas9 system. ( 27767081 )
2016
13
The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata. ( 27780306 )
2016
14
Multilocus microsatellite analysis of European and African Candida glabrata isolates. ( 26946511 )
2016
15
Diversity and antifungal susceptibility of Norwegian Candida glabrata clinical isolates. ( 26861194 )
2016
16
Upregulation of the Adhesin Gene EPA1 Mediated by PDR1 in Candida glabrata Leads to Enhanced Host Colonization. ( 27303714 )
2016
17
Effects of Aspirin as an Anti-inflammatory Drug on Azole-resistant Candida glabrata In Vitro. ( 28028508 )
2016
18
Candida glabrata survives and replicates in human osteoblasts. ( 27073253 )
2016
19
Roles of vacuolar H+-ATPase in the oxidative stress response of Candida glabrata. ( 27370212 )
2016
20
Multiplex PCR designed to differentiate species within the Candida glabrata complex. ( 27810263 )
2016
21
Development of a Candida glabrata dominant nutritional transformation marker utilizing the Aspergillus nidulans acetamidase gene (amdS). ( 26975388 )
2016
22
Opportunistic fungal pathogen Candida glabrata circulates between humans and yellow-legged gulls. ( 27782182 )
2016
23
Heteroresistance to Fluconazole Is a Continuously Distributed Phenotype among Candida glabrata Clinical Strains Associated with In Vivo Persistence. ( 27486188 )
2016
24
Expression of Efflux Pumps and Fatty Acid Activator One Genes in Azole Resistant Candida Glabrata Isolated From Immunocompromised Patients. ( 27424018 )
2016
25
Candida glabrata encodes a longer variant of the mating type (MAT) alpha2 gene in the mating type-like MTL3 locus, which can form homodimers. ( 27650705 )
2016
26
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. ( 27020939 )
2016
27
Candida species isolated from different body sites and their antifungal susceptibility pattern: Cross-analysis of Candida albicans and Candida glabrata biofilms. ( 27915303 )
2016
28
Rapid detection of FKS-associated echinocandin resistance in Candida glabrata. ( 27550360 )
2016
29
Probiotic yeast Saccharomyces boulardii (nom. nud.) modulates adhesive properties of Candida glabrata. ( 27250926 )
2016
30
Propensity Score Analysis of the Role of Initial Antifungal Therapy in the Outcome of Candida glabrata Bloodstream Infections. ( 26976872 )
2016
31
Crz1p regulates pH homeostasis in Candida glabrata by altering membrane lipid composition. ( 27663025 )
2016
32
Gln3 is a main regulator of nitrogen assimilation in Candida glabrata. ( 27222014 )
2016
33
KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. ( 27548283 )
2016
34
Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata. ( 26976780 )
2016
35
Expression Patterns of ABC Transporter Genes in Fluconazole-Resistant Candida glabrata. ( 27744635 )
2016
36
A Murine Model of Candida glabrata Vaginitis Shows No Evidence of an Inflammatory Immunopathogenic Response. ( 26807975 )
2016
37
Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis. ( 27029023 )
2016
38
Reversal of fluconazole resistance induced by a synergistic effect with Acca sellowiana in Candida glabrata strains. ( 27050162 )
2016
39
Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. ( 27015653 )
2016
40
A Network of Paralogous Stress Response Transcription Factors in the Human Pathogen Candida glabrata. ( 27242683 )
2016
41
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria. ( 26806376 )
2016
42
Candida glabrata among Candida spp. from environmental health practitioners of a Brazilian Hospital. ( 26991302 )
2016
43
Fluconazole and Echinocandin Resistance of Candida glabrata Correlates Better with Antifungal Drug Exposure Rather than with MSH2 Mutator Genotype in a French Cohort of Patients Harboring Low Rates of Resistance. ( 28066361 )
2016
44
Micafungin versus caspofungin in the treatment of Candida glabrata infection: a case report. ( 27821139 )
2016
45
Recurrent episodes of Candidemia due to Candida glabrata, Candida tropicalis and Candida albicans with acquired echinocandin resistance. ( 27995055 )
2016
46
In vitro Synergistic Activity of Caspofungin Plus Polymyxin B Against Fluconazole-Resistant Candida glabrata. ( 26992255 )
2016
47
Genetic Drivers of Multidrug Resistance in Candida glabrata. ( 28018323 )
2016
48
Current trends in candidemia and species distribution among adults: Candida glabrata surpasses C. albicans in diabetic patients and abdominal sources. ( 27402377 )
2016
49
Identification of Components of the SUMOylation Machinery in Candida glabrata: ROLE OF THE DESUMOYLATION PEPTIDASE CgUlp2 IN VIRULENCE. ( 27382059 )
2016
50
Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeast Candida glabrata. ( 27347716 )
2016

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.83 IFNG RBPJ
2
Show member pathways
10.56 CSF2 IFNG
3 10.1 CSF2 IFNG

GO Terms for Candida Glabrata

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 CSF2 IFNG
2 cholesterol biosynthetic process GO:0006695 9.43 LSS SQLE
3 regulation of cholesterol biosynthetic process GO:0045540 9.4 LSS SQLE
4 biomineral tissue development GO:0031214 9.37 HTN1 HTN3
5 killing of cells of other organism GO:0031640 9.32 HTN1 HTN3
6 defense response to fungus GO:0050832 9.26 HTN1 HTN3
7 defense response to bacterium GO:0042742 9.26 HTN1 HTN3 IFNG RBPJ
8 myeloid dendritic cell differentiation GO:0043011 9.16 CSF2 RBPJ
9 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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