Aliases & Classifications for Candida Glabrata

MalaCards integrated aliases for Candida Glabrata:

Name: Candida Glabrata 49

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to candidiasis and vaginitis. An important gene associated with Candida Glabrata is CSF2 (Colony Stimulating Factor 2), and among its related pathways/superpathways are Th2 Differentiation Pathway and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and neutrophil, and related phenotypes are immune system and mortality/aging

Wikipedia : 72 Candida glabrata is a haploid yeast of the genus Candida, previously known as Torulopsis glabrata. This... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 candidiasis 29.6 APCS HTN3 IFNG SKAP2
2 vaginitis 10.4
3 vulvovaginitis 10.3
4 trichosporonosis 10.3 CSF2 IFNG
5 cyclic neutropenia 10.3 CSF2 IFNG
6 carotid artery thrombosis 10.3 CSF2 IFNG
7 human t-cell leukemia virus type 2 10.3 CSF2 IFNG
8 meconium aspiration syndrome 10.2 CSF2 IFNG
9 cytomegalovirus retinitis 10.2 CSF2 IFNG
10 cryptococcal meningitis 10.2 CSF2 IFNG
11 vulvovaginal candidiasis 10.2
12 endocarditis 10.2
13 endophthalmitis 10.2
14 smallpox 10.1 CSF2 IFNG
15 chorioamnionitis 10.1
16 langerhans cell histiocytosis 10.1 CSF2 IFNG
17 aging 10.1
18 osteomyelitis 10.1
19 pneumonia 10.1
20 endotheliitis 10.1
21 parasitic protozoa infectious disease 10.0 DHFR IFNG
22 keratitis, hereditary 10.0
23 hematopoietic stem cell transplantation 10.0
24 esophagitis 10.0
25 cholecystitis 10.0
26 peritonitis 10.0
27 oral candidiasis 9.9 HTN3 SKAP2
28 pulmonary sarcoidosis 9.9 CSF2 IFNG
29 angel-shaped phalangoepiphyseal dysplasia 9.8
30 polykaryocytosis inducer 9.8
31 amyotrophic lateral sclerosis 3 9.8
32 pulmonary disease, chronic obstructive 9.8
33 leukemia, chronic myeloid 9.8
34 polyarteritis nodosa, childhood-onset 9.8
35 arthritis 9.8
36 chronic granulomatous disease 9.8
37 diabetes mellitus 9.8
38 leukemia 9.8
39 spinal cord injury 9.8
40 aspiration pneumonia 9.8
41 infective endocarditis 9.8
42 colitis 9.8
43 cutaneous candidiasis 9.8
44 mucositis 9.8
45 malignant otitis externa 9.8
46 epidural abscess 9.8
47 heart disease 9.8
48 constrictive pericarditis 9.8
49 nephrotic syndrome 9.8
50 denture stomatitis 9.8

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 APCS CSF2 DHFR IFNG RBPJ RIF1
2 mortality/aging MP:0010768 9.28 APCS CSF2 DHFR IFNG LSS RBPJ

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
5
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
6
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
7 Steroid Synthesis Inhibitors Phase 4
8 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
9 Cytochrome P-450 CYP3A Inhibitors Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Echinocandins Phase 4
15 Anti-Infective Agents Phase 4
16 Antifungal Agents Phase 4
17
Mechlorethamine Approved, Investigational 51-75-2 4033
18 Sodium hypochlorite
19 chloramine-T
20 Disinfectants
21 Pharmaceutical Solutions
22 Eusol
23 Anti-Infective Agents, Local
24 Castor Nutraceutical
25 Brewer's Yeast Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins Completed NCT00839540 Phase 4 micafungin;Micafungin;Caspofungin
2 Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis Completed NCT00496197 Phase 4 Eraxis (anidulafungin);Diflucan (fluconazole);Vfend (voriconazole)
3 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319
4 Clinical and Laboratorial Evaluation of the Desinfection Solutions in Candida Species From Total Prostheses and Palate of Total Edentulous. Completed NCT03203551
5 Effect of Saccharomyces Cerevisiae on Vulvo-vaginal Candidiasis Recruiting NCT02859493

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

38
Testes, Colon, Neutrophil, Monocytes, Endothelial, Myeloid, Nk Cells

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 663)
# Title Authors Year
1
Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor. ( 29363861 )
2018
2
Comparative Study of the Effects of Fluconazole and Voriconazole on Candida glabrata, Candida parapsilosis and Candida rugosa Biofilms. ( 29380188 )
2018
3
Activity and expression of Candida glabrata vacuolar proteases in autophagy-like conditions. ( 29385574 )
2018
4
Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans. ( 29249661 )
2018
5
Mutant prevention concentration and mutant selection window of micafungin and anidulafungin in clinical<i>Candida glabrata</i>isolates. ( 29311063 )
2018
6
Relative abundance of<i>Candida albicans</i>and<i>Candida glabrata</i>in<i>in vitro</i>co-culture biofilms impacts biofilm structure and formation. ( 29427422 )
2018
7
Deletion of<i>ADA2</i>increases antifungal drug susceptibility and virulence in<i>Candida glabrata</i>. ( 29311082 )
2018
8
Characterisation of an ABC transporter of a resistant Candida glabrata clinical isolate. ( 29412345 )
2018
9
Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata. ( 29248112 )
2018
10
Amphotericin B loaded sulfonated chitosan nanoparticles for targeting macrophages to treat intracellular Candida glabrata infections. ( 29339278 )
2018
11
Enhanced Efflux Pump Activity in Old<i>Candida glabrata</i>. ( 29311061 )
2018
12
A rare case of Candida glabrata spondylodiscitis: case report and literature review. ( 29339229 )
2018
13
Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant<i>Candida tropicalis</i>and<i>Candida glabrata</i>isolates with delineation of their resistance mechanisms. ( 29416360 )
2018
14
Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates. ( 28663342 )
2017
15
Dectin-1 embraces Candida glabrata. ( 28727942 )
2017
16
The phosphorelay signal transduction system in Candida glabrata: an in silico analysis. ( 29248994 )
2017
17
Emergence of Candida glabrata in vulvovaginal candidiasis should be attributed to selective pressure or virulence ability? ( 28730269 )
2017
18
Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata. ( 28831086 )
2017
19
Azole Resistance Caused by Increased Drug Efflux in<i>Candida glabrata</i>Isolated from the Urinary Tract of a Dog with Diabetes Mellitus. ( 29371812 )
2017
20
Galleria mellonella as a host model to study Candida glabrata virulence and antifungal efficacy. ( 28658597 )
2017
21
Interactions between Candida albicans and Candida glabrata in biofilms: Influence of the strain type, culture medium and glucose supplementation. ( 29274093 )
2017
22
Quantification of CDR1 Gene Expression in Fluconazole Resistant Candida Glabrata Strains Using Real-time PCR. ( 28894714 )
2017
23
Candida glabrata Biofilms: How Far Have We Come? ( 29371530 )
2017
24
The Fungal Pathogen Candida glabrata Does Not Depend on Surface Ferric Reductases for Iron Acquisition. ( 28642757 )
2017
25
Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature. ( 29272049 )
2017
26
Fungicidal effect of thymoquinone involves generation of oxidative stress in Candida glabrata. ( 28024529 )
2017
27
De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance. ( 28630180 )
2017
28
CgMED3 Changes Membrane Sterol Composition To Help Candida glabrata Tolerate Low-pH Stress. ( 28667115 )
2017
29
Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata. ( 29228268 )
2017
30
Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. ( 28710262 )
2017
31
Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. ( 28814823 )
2017
32
Genome mining, in silico validation and phase selection of a novel aldo-keto reductase from Candida glabrata for biotransformation. ( 28644714 )
2017
33
Fungicidal activity of copper-sputtered flexible surfaces under dark and actinic light against azole-resistant Candida albicans and Candida glabrata. ( 28802173 )
2017
34
Enantioselective bioreduction of benzo-fused cyclic ketones with engineered Candida glabrata ketoreductase 1 - a promising synthetic route to ladostigil (TV3326). ( 28848953 )
2017
35
Functional analysis of selected deletion mutants in Candida glabrata under hypoxia. ( 28664376 )
2017
36
Lumbar Spinal Candida Glabrata Treated Without Surgical Intervention: A Case Report. ( 28744418 )
2017
37
Differentiation of Candida albicans, Candida glabrata, and Candida krusei by FT-IR and chemometrics by CHROMagara8c Candida. ( 28822772 )
2017
38
Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species. ( 28700656 )
2017
39
Repeated applications of photodynamic therapy on Candida glabrata biofilms formed in acrylic resin polymerized. ( 28091850 )
2017
40
Dectin-1 plays an important role in host defense against systemic Candida glabrata infection. ( 28658592 )
2017
41
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance. ( 29364212 )
2017
42
The CgHaa1-Regulon Mediates Response and Tolerance to Acetic Acid Stress in the Human Pathogen Candida glabrata. ( 27815348 )
2017
43
In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes Echinocandin Resistance in Candida glabrata Isolates. ( 27872063 )
2017
44
NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7. ( 27736647 )
2016
45
Opportunistic fungal pathogen Candida glabrata circulates between humans and yellow-legged gulls. ( 27782182 )
2016
46
Multiplex PCR designed to differentiate species within the Candida glabrata complex. ( 27810263 )
2016
47
Fluconazole and Echinocandin Resistance of Candida glabrata Correlates Better with Antifungal Drug Exposure Rather than with MSH2 Mutator Genotype in a French Cohort of Patients Harboring Low Rates of Resistance. ( 28066361 )
2016
48
Fungal CYP51 Inhibitors VT-1161 and VT-1129 exhibit strong in vitro activity against Candida glabrata and C. krusei isolates clinically resistant to azole and echinocandin antifungal compounds. ( 27956419 )
2016
49
Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeast Candida glabrata. ( 27347716 )
2016
50
Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor. ( 27449515 )
2016

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 IFNG RBPJ
2
Show member pathways
10.51 CSF2 IFNG
3 10.1 CSF2 IFNG

GO Terms for Candida Glabrata

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.54 HTN1 HTN3 RBPJ
2 antimicrobial humoral response GO:0019730 9.46 HTN1 HTN3
3 cholesterol biosynthetic process GO:0006695 9.43 LSS SQLE
4 killing of cells of other organism GO:0031640 9.4 HTN1 HTN3
5 biomineral tissue development GO:0031214 9.32 HTN1 HTN3
6 regulation of cholesterol biosynthetic process GO:0045540 9.26 LSS SQLE
7 defense response to fungus GO:0050832 9.16 HTN1 HTN3
8 myeloid dendritic cell differentiation GO:0043011 8.96 CSF2 RBPJ
9 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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