MCID: CND004
MIFTS: 61

Candidiasis malady

Genetic diseases, Rare diseases, Infectious diseases categories
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Summaries for Candidiasis

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.

MalaCards: Candidiasis, also known as systemic candidiasis, is related to chronic mucocutaneous candidiasis and oral candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Cytokine production by Th17 cells in CF and IL-17 Family Signaling Pathways. The drug flucytosine and the compounds flagellin and zymosan have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and brain, and related mouse phenotypes are digestive/alimentary and respiratory system.

CDC:4 Photomicrograph of the fungus Candida albicans

Wikipedia:65 Candidiasis, thrush or yeast infection is a fungal infection (mycosis) of any species from the genus... more...

Aliases & Classifications for Candidiasis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 43NIH Rare Diseases, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

candidiasis 8 10 45 62
systemic candidiasis 8 43 62
disseminated candidiasis 8 45
systemic candida infections 43


External Ids:

Disease Ontology8 DOID:1508
ICD9CM27 112, 112.9
NCIt40 C26711
MeSH35 D002177
ICD1025 B37, B37.9

Related Diseases for Candidiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Candidiasis family:

Familial Candidiasis 5 Familial Candidiasis 2
Familial Candidiasis 6 Candidiasis, Familial, 7
Candidiasis, Familial, 8 Candidiasis, Familial, 3

Diseases related to Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1chronic mucocutaneous candidiasis31.7STAT1
2oral candidiasis31.6DEFB4A, HTN3, LTF
3pneumonia30.3IL17F, DEFB1, DEFB4A
4hepatitis30.2LTF, STAT1
5autoimmune polyendocrine syndrome30.1CARD9
6asthma30.0DEFB4A, DEFB1, STAT1, IL17F
7tuberculosis30.0DEFB4A, CLEC7A, STAT1
8vasculitis29.9LTF, SH2D1A
9coccidioidomycosis29.9CLEC7A
10arthritis29.7LTF, IL17RA, STAT1
11sepsis29.6LTF, DEFB1, DEFB4A
12cystic fibrosis29.6DEFB4A, DEFB1, LTF
13vulvovaginal candidiasis11.1
14vulvovaginitis11.1
15esophageal candidiasis10.9
16esophagitis10.8
17vaginitis10.8
18neonatal candidiasis10.7
19bacterial vaginosis10.5
20trichomoniasis10.4
21leukoplakia10.4
22blindness10.4
23aspergillosis10.4
24candida glabrata10.4
25leukemia10.4
26thymoma10.3
27candidiasis, familial, 2, autosomal recessive10.3
28acquired immunodeficiency syndrome10.3
29autoimmune polyendocrine syndrome type 110.3
30hiv/aids10.3
31invasive aspergillosis10.2
32diabetes mellitus10.2
33acute leukemia10.2
34candidal paronychia10.2
35meningitis10.2
36alopecia10.2
37herpes simplex10.2
38laryngitis10.2
39familial candidiasis 610.2
40autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2
41hypoparathyroidism10.1
42cryptococcosis10.1
43dermatophytosis10.1
44histoplasmosis10.1
45hypothyroidism10.1
46keratitis10.1
47candidiasis familial chronic mucocutaneous, autosomal recessive10.1
48kid syndrome10.1
49familial candidiasis 510.1
50familial candidiasis 210.1

Graphical network of the top 20 diseases related to Candidiasis:



Diseases related to candidiasis

Symptoms for Candidiasis

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Drugs & Therapeutics for Candidiasis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Candidiasis

Search NIH Clinical Center for Candidiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

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33MalaCards
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MalaCards organs/tissues related to Candidiasis:

33
Lung, Skin, Brain, Heart, T cells, Colon, Testes, Tongue, Liver, Kidney, Bone, Monocytes, Thyroid, Bone marrow, Myeloid, B cells, Thymus, Small intestine, Pituitary

Animal Models for Candidiasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Candidiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1IL17F, STAT1, CLEC7A, AIRE
2MP:00053888.7AIRE, CLEC7A, IL17F, IL17RA
3MP:00053767.5AIRE, SH2D1A, CLEC7A, STAT1, IL17RA, CARD9
4MP:00053977.3AIRE, SH2D1A, CLEC7A, STAT1, IL17F, IL17RA
5MP:00053876.5LTF, AIRE, DEFB1, SH2D1A, CLEC7A, STAT1

Publications for Candidiasis

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52PubMed
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Articles related to Candidiasis:

(show top 50)    (show all 1541)
idTitleAuthorsYear
1
I^-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Necessity is the mother of invention. (24180439)
2013
2
Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. (24152852)
2013
3
Management of candidaemia and invasive candidiasis in critically ill patients. (23664579)
2013
4
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
5
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
6
Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs. (23738751)
2013
7
Distribution of Candida species among HIV-positive patients with oropharyngeal candidiasis in Accra, Ghana. (23324819)
2013
8
Biochemical analysis and application of molecular display technology on Candida albicans for diagnosing and preventing candidiasis. (24189555)
2013
9
Invasive candidiasis as a cause of sepsis in the critically ill patient. (24157707)
2013
10
Cutaneous candidiasis caused by Candida glabrata in a HIV/AIDS patient. (23970580)
2013
11
Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis. (23334938)
2013
12
Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis. (22052380)
2012
13
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
14
Clinical heterogeneity and diagnostic delay of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. (21295522)
2011
15
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
16
New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome. (21346738)
2011
17
Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans. (21502632)
2011
18
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. (20876174)
2010
19
Oral mucous squamous cell carcinoma-an anticipated consequence of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (20304522)
2010
20
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. (20123958)
2010
21
Challenging issues in neonatal candidiasis. (20513206)
2010
22
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
23
Brain stem candidiasis mimicking cerebellopontine angle tumor. (18313733)
2008
24
An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis. (17409603)
2007
25
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
26
Oral candidiasis infections with limited clinical findings. (16884077)
2006
27
Molecular evidence of congenital candidiasis associated with maternal candidal vaginitis. (16804443)
2006
28
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
29
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
30
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome with renal failure: impact of posttransplant immunosuppression on disease activity. (16263818)
2006
31
Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients. (16110781)
2005
32
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
33
Esophageal candidiasis. (16408552)
2005
34
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
35
Vulvovaginal candidiasis. (12228137)
2002
36
Pathogenesis of Recurrent Vulvovaginal Candidiasis. (12433327)
2002
37
Identification of a novel mutation in the autoimmune regulator (AIRE- 1) gene in a French family with autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy. (11275943)
2001
38
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
39
Novel mutations of the autoimmune regulator gene in two siblings with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. (10946904)
2000
40
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
41
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
42
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
43
Refractory esophageal candidiasis associated with a low molecular weight plasma inhibitor of T-lymphocyte function. (3487248)
1986
44
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment. (3917209)
1985
45
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
46
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
47
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
48
Clotrimazole: intermittent therapy in chronic mucocutaneous candidiasis. (842517)
1977
49
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
50
Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. (4604245)
1974

Variations for Candidiasis

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Expression for genes affiliated with Candidiasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Candidiasis

Search GEO for disease gene expression data for Candidiasis.

Pathways for genes affiliated with Candidiasis

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50PathCards, 60Thomson Reuters, 55Reactome, 54R&D Systems, 38NCBI BioSystems Database, 30KEGG, 5Cell Signaling Technology
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Compounds for genes affiliated with Candidiasis

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Candidiasis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1flagellin45 2911.0STAT1, DEFB4A
2zymosan459.6LTF, CLEC7A
3pmma459.6HTN3, LTF
4sb 20358045 6110.6STAT1, DEFB4A, AIRE
5hbd2459.5DEFB1, DEFB4A
6deferoxamine45 1110.5LTF, STAT1
7ribavirin45 51 1111.5LTF, STAT1
8endotoxin459.4DEFB4A, STAT1, LTF
9mannose459.3LTF, CLEC7A, DEFB4A
10anti-fungal459.2LTF, HTN3, DEFB4A
11ciprofloxacin45 51 1111.2LTF, DEFB1
12polymyxin b459.2DEFB1, LTF
13fluconazole45 1110.1LTF, HTN3, SH2D1A
14nacl458.9LTF, DEFB1, DEFB4A
15rantes458.8DEFB4A, DEFB1, STAT1, IL17RA
16tyrosine458.5AIRE, DEFB4A, SH2D1A, CLEC7A, STAT1
17cysteine458.3LTF, HTN3, STAT1, DEFB4A
18retinoic acid45 249.2DEFB4A, DEFB1, STAT1, LTF
19dexamethasone45 51 29 1111.1DEFB4A, DEFB1, CLEC7A, STAT1, LTF

GO Terms for genes affiliated with Candidiasis

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16Gene Ontology
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Cellular components related to Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.4LTF, IL17RA, IL17F, HTN3, DEFB1, DEFB4A

Biological processes related to Candidiasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-2 biosynthetic processGO:04507610.1CARD9, IL17F
2regulation of interleukin-6 biosynthetic processGO:04540810.1CARD9, IL17F
3positive regulation of cytokine production involved in inflammatory responseGO:19000179.9IL17F, IL17RA
4response to exogenous dsRNAGO:0433309.8CARD9, STAT1
5negative regulation of angiogenesisGO:0165259.8IL17F, STAT1
6positive regulation of tumor necrosis factor productionGO:0327609.6CLEC7A, CARD9
7humoral immune responseGO:0069599.2LTF, SH2D1A, AIRE
8defense response to bacteriumGO:0427428.8HTN3, DEFB1, DEFB4A
9immune responseGO:0069558.7DEFB1, DEFB4A, AIRE
10innate immune responseGO:0450878.6DEFB4A, DEFB1, CLEC7A, CARD9

Products for genes affiliated with Candidiasis

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Sources for Candidiasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet