MCID: CND004
MIFTS: 55

Candidiasis malady

Infectious category

Summaries for Candidiasis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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Disease Ontology:8 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.

MalaCards: Candidiasis, also known as systemic candidiasis, is related to oral candidiasis and chronic mucocutaneous candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Immune System and Lymphocyte Signaling. The drug flucytosine and the compounds dexamethasone and anti-fungal have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Photomicrograph of the fungus Candida albicans

Wikipedia:64 Candidiasis or thrush is a fungal infection (mycosis) of any species from the genus Candida (one genus... more...

Aliases & Classifications for Candidiasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 43NIH Rare Diseases, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

candidiasis 8 10 45 61
systemic candidiasis 8 43 61
disseminated candidiasis 8 45
systemic candida infections 43


External Ids:

Disease Ontology8 DOID:1508
ICD9CM27 112.9, 112
MeSH35 D002177
NCIt40 C26711
ICD1025 B37, B37.9

Related Diseases for Candidiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Candidiasis family:

familial candidiasis 5 familial candidiasis 2
familial candidiasis 6 candidiasis, familial, 7
candidiasis, familial, 8 candidiasis, familial, 3

Diseases related to Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 293)
idRelated DiseaseScoreTop Affiliating Genes
1oral candidiasis31.7SKAP2, CD9, LTF, DEFB4A, HTN3
2chronic mucocutaneous candidiasis31.5IL10, AIRE
3bacterial vaginosis30.7MBL2, LTF
4aspergillosis30.5MBL2, CD79A
5acute leukemia30.4STAT1, MPO
6alopecia30.2AIRE
7asthma30.2MBL2, STAT1, MPO, DEFB1, DEFB4A, CD79A
8tuberculosis30.1MBL2, STAT1, DEFB4A, CD9, CD79A, IL10
9systemic lupus erythematosus30.1MBL2, STAT1, MPO, LTF, CD79A, IL10
10hepatitis c30.1STAT1, LTF, IL10, IL4
11alopecia areata30.1AIRE
12autoimmune polyendocrine syndrome30.1CARD9
13vasculitis29.9MBL2, MPO, SH2D1A, LTF, CD79A
14autoimmune hemolytic anemia29.9CD79A
15thyroiditis29.9MBL2, CD79A
16cystic fibrosis29.7MBL2, MPO, DEFB1, DEFB103B, LTF, DEFB4A
17sepsis29.7MBL2, MPO, DEFB1, DEFB4A, LTF, CD9
18arthritis29.7STAT1, MPO, LTF, IL10, IL4, IL17RA
19atopy29.7MPO, CD79A, IL10, IL4
20cryptosporidiosis29.7MBL2, CD79A
21lichen planus29.7DEFB4A
22vitiligo29.7AIRE
23deficiency anemia29.7CD79A
24churg-strauss syndrome29.7MPO, LTF
25toxoplasmosis29.7CD9, CD79A
26pemphigus29.7CD79A
27uveitis29.7IL4, IL10
28vulvovaginal candidiasis11.1
29esophageal candidiasis10.9
30neonatal candidiasis10.7
31trichomoniasis10.4
32leukoplakia10.4
33oral cancer10.4
34oral leukoplakia10.4
35candida glabrata10.4
36acquired immunodeficiency syndrome10.3
37thymoma10.3
38candidiasis, familial, 2, autosomal recessive10.3
39autoimmune polyendocrine syndrome type 110.3
40invasive aspergillosis10.2
41vaginitis10.2
42squamous cell carcinoma10.2
43familial candidiasis 610.2
44autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2
45candidal paronychia10.1
46hypoparathyroidism10.1
47vulvovaginitis10.1
48cryptococcosis10.1
49candidiasis familial chronic mucocutaneous, autosomal recessive10.1
50familial candidiasis 510.1

Graphical network of the top 20 diseases related to Candidiasis:



Diseases related to candidiasis

Clinical Features for Candidiasis

Drugs & Therapeutics for Candidiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Candidiasis

Drug clinical trials:

Search ClinicalTrials for Candidiasis

Search NIH Clinical Center for Candidiasis

Search CenterWatch for Candidiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Candidiasis

Anatomical Context for Candidiasis

Animal Models for Candidiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Candidiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7SKAP2, CARD9, MBL2, APCS, STAT1, MPO
2MP:000539710.6AIRE, SH2D1A, MPO, STAT1, APCS, MBL2
3MP:000301210.5IL17RA, AIRE, STAT1
4MP:000537610.4CARD9, MBL2, STAT1, MPO, SH2D1A, AIRE

Publications for Candidiasis

Sources:
51PubMed
See all sources

Articles related to Candidiasis:

(show top 50)    (show all 1555)
idTitleAuthorsYear
1
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
2
Ocular candidiasis complicated by branch retinal vein occlusion. (23335209)
2013
3
The IL-17-induced Lipocalin 2 is dispensable for immunity to oral candidiasis. (24343647)
2013
4
Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. (22934533)
2013
5
Human monoclonal antibody-based therapy in the treatment of invasive candidiasis. (23878583)
2013
6
Opportunistic yeast infections: candidiasis, cryptococcosis, trichosporonosis and geotrichosis. (23621330)
2013
7
Effect of erythrosine- and LED-mediated photodynamic therapy on buccal candidiasis infection of immunosuppressed mice and Candida albicans adherence to buccal epithelial cells. (22727094)
2012
8
N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. (21859389)
2012
9
Candida virulence properties and adverse clinical outcomes in neonatalA candidiasis. (22504098)
2012
10
Th1 immunity induction by ginsenoside Re involves in protection of mice against disseminated candidiasis due to Candida albicans. (22940185)
2012
11
Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis. (23144964)
2012
12
Invasive candidiasis: new insights presaging new therapeutic approaches? (22927458)
2012
13
Candidiasis (oropharyngeal). (22348417)
2012
14
Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. (21788462)
2011
15
Epidemiology and prevention of neonatal candidiasis: fluconazole for all neonates? (20204759)
2010
16
Risk factors for recurrent vulvovaginal candidiasis. (21061843)
2010
17
Treatment of gastric candidiasis in patients with gastric ulcer disease: are antifungal agents necessary? (20479898)
2009
18
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
19
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. (18957581)
2008
20
Vulvovaginal candidiasis. (16434042)
2006
21
Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. (15041994)
2004
22
Histopathologic and scanning electron microscope examination of the nail and hair in chronic mucocutaneous candidiasis. (12894108)
2003
23
Efficacy of human salivary mucin MUC7-derived peptide and histatin 5 in a murine model of candidiasis. (14659657)
2003
24
Lupus-like panniculitis in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (12951636)
2003
25
Vulvovaginal candidiasis. (12742894)
2003
26
Vulvovaginal candidiasis. (12228137)
2002
27
Nonspecific secretory immunity in HIV-infected patients with oral candidiasis. (12439202)
2002
28
The secreted aspartic proteinases as a new target in the therapy of candidiasis. (12182226)
2002
29
Characterization of the cellular immune function of patients with chronic mucocutaneous candidiasis. (11207655)
2001
30
Pseudotumoral hyperplastic form of oral candidiasis. (11507568)
2000
31
Treatment of recurrent vulvovaginal candidiasis. (10865926)
2000
32
Recurrent vulvovaginal candidiasis - allergy or immune deficiency? (10224442)
1999
33
Symptomatic eosinophilic esophagitis and esophageal candidiasis. (9772086)
1998
34
Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. (9797228)
1998
35
Oral candidiasis: clinical manifestations, diagnosis, and treatment. (9573835)
1997
36
Microanatomy of the dental enamel in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): report of three cases. (8872708)
1996
37
Opportunistic oral infections in the immunosuppressed patient: oral hairy leukoplakia and oral candidiasis. (8934929)
1996
38
Extensive esophageal candidiasis in the absence of oral lesions in pediatric AIDS. (8576800)
1995
39
Candida zeylanoides causing candidiasis as tinea cruris. (8243128)
1993
40
Acute oral candidiasis during febrile episodes in immunocompromised patients with haematologic malignancies. (2196672)
1990
41
Reduced CD4 + T cells and severe oral candidiasis in absence of HIV infection. (2564487)
1989
42
Papers selected from presentations given at the symposium "Vulvovaginal Candidiasis: Current Views". January 10-11, 1987. (3364510)
1988
43
Comparison of clotrimazole with nystatin in preventing oral candidiasis in neutropaenic patients. (3198184)
1988
44
Clinical diagnosis and treatment of oral candidiasis. (3858462)
1985
45
Treatment of chronic mucocutaneous candidiasis with 5-fluorocytosine. (6756218)
1982
46
Immunological investigation of patients with chronic mucocutaneous candidiasis. (399626)
1979
47
Intravenous miconazole in the treatment of chronic esophageal candidiasis. (830582)
1977
48
Effects of triamcinolone acetonide on experimental oral candidiasis in monkeys. (1056095)
1975
49
MONISTAT: a new fungicide for treatment of vulvovaginal candidiasis. (4429114)
1974
50
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4193722)
1970

Genetic Variations for Candidiasis

Expression for genes affiliated with Candidiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Candidiasis

Search GEO for disease gene expression data for Candidiasis.

Pathways for genes affiliated with Candidiasis

Sources:
54Reactome, 4Cell Signaling Technology, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 53R&D Systems
See all sources

Compounds for genes affiliated with Candidiasis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1114.1MBL2, STAT1, DEFB103B, IL4, IL10, CD79A
2anti-fungal4511.0DEFB103B, APCS, HTN3, MBL2, DEFB4A, LTF
3cysteine4511.0MBL2, HTN3, IL4, CD79A, CD9, LTF
4paraffin4511.0MBL2, CD79A, DEFB4A, IL4, IL10, MPO
5rantes4511.0IL17RA, IL4, CD9, DEFB4A, MBL2, STAT1
6neopterin4511.0LTF, CD9, CD79A, IL10, IL4, MBL2
7polymyxin b4511.0MBL2, IL4, DEFB1, LTF, IL10
8ribavirin45 50 1113.0LTF, STAT1, MBL2, IL4, IL10
9histamine45 29 2413.0DEFB4A, MPO, CD79A, IL10, IL4, LTF
10fluconazole45 1112.0SH2D1A, LTF, HTN3, CD79A
11vegf4511.0IL4, IL10, CD79A, LTF, MPO, STAT1
12pentoxifylline45 1112.0MPO, CD9, LTF, IL4
13mannose4511.0CD9, CD79A, DEFB4A, MBL2, LTF
14con a4511.0MBL2, IL4, IL10, CD79A
15methacholine45 1111.9IL4, MPO, LTF, CD79A
16hypothiocyanite45 2411.9LTF, CD79A, MPO
17acidophilus4510.9MPO, IL10, IL4
18thiocyanate45 2411.9MPO, LTF, CD79A
19n acetylcysteine4510.9CD79A, STAT1, MPO, IL4, LTF
20hbd24510.9DEFB103B, DEFB4A, DEFB1
21tuberculin4510.9MBL2, IL10, CD79A
22sb 20358045 6011.9DEFB4A, AIRE, IL10, IL4, STAT1
23cyclophosphamide45 50 1112.9MBL2
24praziquantel45 1111.9CD79A, IL10, IL4
25polyethylene glycol4510.9CD79A, IL4, CD9, MPO
26mdms4510.9IL10, CD9, STAT1
27pmma4510.9CD79A, LTF, HTN3
28azathioprine45 50 2 1113.9IL10, CD79A, IL4, LTF
29retinoic acid45 2411.9CD9, LTF, CD79A, DEFB4A, DEFB1, MPO
30zymosan4510.9MBL2, LTF, MPO
31biotin45 11 2412.9IL4, IL10, CD79A, STAT1
32prednisolone45 29 1112.9IL10, MBL2, MPO, CD79A
33indomethacin45 60 29 1113.9LTF
34monomethyl fumarate4510.8IL4, IL10
35okt34510.8IL4, IL10, CD79A
36saquinavir45 1111.8SKAP2, CD9, APCS
37budesonide45 50 1112.8IL4, MPO, LTF
38lipoteichoic acid4510.8IL10, MBL2, DEFB4A
39thyroxine45 2411.8CD79A, MBL2, IL10, IL4
40polyinosinic-polycytidylic acid4510.8STAT1, IL10, IL4
41endotoxin4510.8STAT1, DEFB4A, LTF
42cyclosporin a45 29 6012.7CD79A, LTF, STAT1
43rolipram45 60 2912.7CD9
44hypoxanthine45 11 2412.7MPO, IL4, LTF
45dmso4510.7MPO, HTN3, IL10, STAT1
46betaseron4510.6IL10, IL4
47dextran sulfate4510.5MPO, CD9, LTF
48naphthol as-d chloroacetate4510.5LTF, MPO
49nacl4510.4MBL2, DEFB1, DEFB4A, LTF
50peptidoglycan45 2911.2MBL2, IL10, DEFB4A

GO Terms for genes affiliated with Candidiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6MBL2, HTN3, APCS, DEFB1, DEFB4A, LTF
2extracellular spaceGO:00561510.3MBL2, APCS, MPO, IL10, IL17F, IL4

Biological processes related to Candidiasis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274210.8MBL2, DEFB1, DEFB4A, LTF, IL10, HTN3
2negative regulation of growth of symbiont in hostGO:04413010.8MPO, IL10, MBL2
3regulation of interleukin-2 biosynthetic processGO:04507610.7IL17F, CARD9
4regulation of isotype switchingGO:04519110.7IL4, IL10
5regulation of interleukin-6 biosynthetic processGO:04540810.7IL17F, CARD9
6humoral immune responseGO:00695910.7LTF, AIRE, SH2D1A
7type 2 immune responseGO:04209210.6IL10, IL4
8B cell differentiationGO:03018310.6IL10, CD79A, IL4
9positive regulation of cytokine production involved in inflammatory responseGO:190001710.5IL17RA, IL17F
10B cell proliferationGO:04210010.5IL10, CD79A
11positive regulation of MHC class II biosynthetic processGO:04534810.4IL10, IL4
12negative regulation of nitric oxide biosynthetic processGO:04501910.2IL10, IL4

Products for genes affiliated with Candidiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Candidiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet