MCID: CND004
MIFTS: 62

Candidiasis malady

Genetic diseases, Rare diseases, Infectious diseases categories
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Summaries for Candidiasis

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Disease Ontology:8 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.

MalaCards based summary: Candidiasis, also known as disseminated candidiasis, is related to chronic mucocutaneous candidiasis and oral candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Cytokine production by Th17 cells in CF and IL-17 Family Signaling Pathways. The drug flucytosine and the compounds flagellin and zymosan have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and skin, and related mouse phenotypes are digestive/alimentary and respiratory system.

CDC:3 Photomicrograph of the fungus Candida albicans

Wikipedia:65 Candidiasis, thrush, or yeast infection is a fungal infection (mycosis) of any species from the genus... more...

Aliases & Classifications for Candidiasis

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Candidiasis, Aliases & Descriptions:

Name: Candidiasis 8 10 44 62
Disseminated Candidiasis 8 44 62
 
Systemic Candidiasis 8 42 62
Systemic Candida Infections 42 62


Classifications:



External Ids:

Disease Ontology8 DOID:1508
ICD9CM27 112.9, 112
NCIt39 C26711
MeSH34 D002177
ICD1025 B37, B37.9

Related Diseases for Candidiasis

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Diseases in the Candidiasis family:

Familial Candidiasis 5 Familial Candidiasis 2
Familial Candidiasis 6 Candidiasis, Familial, 7
Candidiasis, Familial, 8 Candidiasis, Familial, 3

Diseases related to Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1chronic mucocutaneous candidiasis32.3STAT1
2oral candidiasis31.6LTF, DEFB4A, HTN3
3autoimmune polyendocrine syndrome30.7CARD9
4coccidioidomycosis30.4CLEC7A
5hepatitis30.2LTF, STAT1
6pneumonia30.2IL17F, DEFB1, DEFB4A
7primary sclerosing cholangitis30.0AIRE, LTF
8tuberculosis30.0DEFB4A, CLEC7A, STAT1
9vasculitis29.9LTF, SH2D1A
10asthma29.8DEFB4A, STAT1, IL17F, DEFB1
11arthritis29.6IL17RA, LTF, STAT1
12sepsis29.4DEFB4A, DEFB1, LTF
13cystic fibrosis29.3LTF, DEFB4A, DEFB1
14vulvovaginal candidiasis11.1
15vulvovaginitis11.1
16esophageal candidiasis10.9
17esophagitis10.9
18vaginitis10.8
19neonatal candidiasis10.7
20bacterial vaginosis10.5
21trichomoniasis10.4
22leukoplakia10.4
23candida glabrata10.4
24blindness10.4
25leukemia10.4
26aspergillosis10.4
27thymoma10.4
28hiv/aids10.3
29acquired immunodeficiency syndrome10.3
30autoimmune polyendocrine syndrome type 110.3
31diabetes mellitus10.3
32invasive aspergillosis10.3
33candidal paronychia10.3
34acute leukemia10.2
35meningitis10.2
36candidiasis, familial, 4, autosomal recessive10.2
37ulcerative colitis10.2LTF
38herpes simplex10.2
39laryngitis10.2
40autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2
41alopecia10.1
42systemic lupus erythematosus10.1
43cryptococcosis10.1
44hypoparathyroidism10.1
45dermatophytosis10.1
46histoplasmosis10.1
47hypothyroidism10.1
48keratitis10.1
49lupus erythematosus10.1
50candidiasis familial chronic mucocutaneous, autosomal recessive10.1

Graphical network of the top 20 diseases related to Candidiasis:



Diseases related to candidiasis

Symptoms for Candidiasis

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Drugs & Therapeutics for Candidiasis

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Drug clinical trials:

Search ClinicalTrials for Candidiasis

Search NIH Clinical Center for Candidiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

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MalaCards organs/tissues related to Candidiasis:

32
Brain, Lung, Skin, Heart, T cells, Colon, Testes, Kidney, Neutrophil, Liver, Tongue, Bone, Monocytes, Bone marrow, Thyroid, Thymus, Myeloid, B cells, Small intestine, Pituitary

Animal Models for Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1STAT1, CLEC7A, AIRE, IL17F
2MP:00053888.7AIRE, IL17RA, IL17F, CLEC7A
3MP:00053767.5LTF, CARD9, IL17RA, STAT1, CLEC7A, SH2D1A
4MP:00053977.3LTF, CARD9, IL17RA, IL17F, STAT1, CLEC7A
5MP:00053876.5CARD9, IL17RA, IL17F, STAT1, CLEC7A, SH2D1A

Publications for Candidiasis

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Articles related to Candidiasis:

(show top 50)    (show all 1601)
idTitleAuthorsYear
1
Comment on "Vulvovaginal Candidiasis as a Chronic Disease: Diagnostic Criteria and Definition" (24769654)
2014
2
Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis. (25143944)
2014
3
Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis. (25315503)
2014
4
I^-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Necessity is the mother of invention. (24180439)
2013
5
Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. (24152852)
2013
6
Management of candidaemia and invasive candidiasis in critically ill patients. (23664579)
2013
7
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
8
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
9
Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs. (23738751)
2013
10
Distribution of Candida species among HIV-positive patients with oropharyngeal candidiasis in Accra, Ghana. (23324819)
2013
11
Biochemical analysis and application of molecular display technology on Candida albicans for diagnosing and preventing candidiasis. (24189555)
2013
12
Invasive candidiasis as a cause of sepsis in the critically ill patient. (24157707)
2013
13
Cutaneous candidiasis caused by Candida glabrata in a HIV/AIDS patient. (23970580)
2013
14
Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis. (22052380)
2012
15
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
16
Clinical heterogeneity and diagnostic delay of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. (21295522)
2011
17
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
18
New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome. (21346738)
2011
19
Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans. (21502632)
2011
20
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. (20876174)
2010
21
Oral mucous squamous cell carcinoma-an anticipated consequence of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (20304522)
2010
22
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. (20123958)
2010
23
Challenging issues in neonatal candidiasis. (20513206)
2010
24
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
25
Brain stem candidiasis mimicking cerebellopontine angle tumor. (18313733)
2008
26
An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis. (17409603)
2007
27
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
28
Oral candidiasis infections with limited clinical findings. (16884077)
2006
29
Molecular evidence of congenital candidiasis associated with maternal candidal vaginitis. (16804443)
2006
30
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
31
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
32
Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients. (16110781)
2005
33
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
34
Esophageal candidiasis. (16408552)
2005
35
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
36
Vulvovaginal candidiasis. (12228137)
2002
37
Identification of a novel mutation in the autoimmune regulator (AIRE- 1) gene in a French family with autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy. (11275943)
2001
38
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
39
Novel mutations of the autoimmune regulator gene in two siblings with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. (10946904)
2000
40
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
41
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
42
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
43
Refractory esophageal candidiasis associated with a low molecular weight plasma inhibitor of T-lymphocyte function. (3487248)
1986
44
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment. (3917209)
1985
45
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
46
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
47
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
48
Clotrimazole: intermittent therapy in chronic mucocutaneous candidiasis. (842517)
1977
49
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
50
Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. (4604245)
1974

Variations for Candidiasis

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Expression for genes affiliated with Candidiasis

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Expression patterns in normal tissues for genes affiliated with Candidiasis

Search GEO for disease gene expression data for Candidiasis.

Pathways for genes affiliated with Candidiasis

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Compounds for genes affiliated with Candidiasis

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Compounds related to Candidiasis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1flagellin44 2811.0DEFB4A, STAT1
2zymosan449.6CLEC7A, LTF
3pmma449.6HTN3, LTF
4sb 20358044 6110.6DEFB4A, STAT1, AIRE
5hbd2449.5DEFB4A, DEFB1
6deferoxamine44 1110.5STAT1, LTF
7ribavirin44 50 1111.5STAT1, LTF
8endotoxin449.4LTF, STAT1, DEFB4A
9mannose449.3DEFB4A, CLEC7A, LTF
10anti-fungal449.2LTF, HTN3, DEFB4A
11ciprofloxacin44 50 1111.2DEFB1, LTF
12polymyxin b449.2DEFB1, LTF
13fluconazole44 1110.1SH2D1A, LTF, HTN3
14nacl448.9DEFB4A, DEFB1, LTF
15rantes448.8DEFB4A, DEFB1, IL17RA, STAT1
16tyrosine448.5SH2D1A, DEFB4A, CLEC7A, AIRE, STAT1
17cysteine448.3LTF, HTN3, STAT1, DEFB4A
18retinoic acid44 249.2LTF, STAT1, DEFB4A, DEFB1
19dexamethasone44 50 28 1111.1CLEC7A, DEFB1, DEFB4A, STAT1, LTF

GO Terms for genes affiliated with Candidiasis

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Cellular components related to Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.4LTF, IL17RA, IL17F, HTN3, DEFB1, DEFB4A

Biological processes related to Candidiasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-2 biosynthetic processGO:04507610.1CARD9, IL17F
2regulation of interleukin-6 biosynthetic processGO:04540810.1IL17F, CARD9
3positive regulation of cytokine production involved in inflammatory responseGO:19000179.9IL17F, IL17RA
4response to exogenous dsRNAGO:0433309.8STAT1, CARD9
5negative regulation of angiogenesisGO:0165259.8STAT1, IL17F
6positive regulation of tumor necrosis factor productionGO:0327609.6CARD9, CLEC7A
7humoral immune responseGO:0069599.2AIRE, LTF, SH2D1A
8defense response to bacteriumGO:0427428.8DEFB4A, DEFB1, HTN3
9immune responseGO:0069558.7AIRE, DEFB4A, DEFB1
10innate immune responseGO:0450878.6DEFB4A, DEFB1, CLEC7A, CARD9

Products for genes affiliated with Candidiasis

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Sources for Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet