MCID: CND004
MIFTS: 63

Candidiasis malady

Infectious diseases category

Summaries for Candidiasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.

MalaCards: Candidiasis, also known as systemic candidiasis, is related to oral candidiasis and chronic mucocutaneous candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Immune System and Lymphocyte Signaling. The drug flucytosine and the compounds dexamethasone and anti-fungal have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and brain, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Photomicrograph of the fungus Candida albicans

Wikipedia:63 Candidiasis or thrush is a fungal infection (mycosis) of any species from the genus Candida (one genus... more...

Aliases & Classifications for Candidiasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

candidiasis 8 10 44 60
systemic candidiasis 8 42 60
disseminated candidiasis 8 44
systemic candida infections 42


External Ids:

Disease Ontology8 DOID:1508
ICD9CM27 112.9, 112
MeSH34 D002177
NCIt39 C26711
ICD1025 B37, B37.9

Related Diseases for Candidiasis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Candidiasis family:

Familial Candidiasis 5 Familial Candidiasis 2
Familial Candidiasis 6 Candidiasis, Familial, 7
Candidiasis, Familial, 8 Candidiasis, Familial, 3

Diseases related to Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1oral candidiasis31.6SKAP2, CD9, LTF, DEFB4A, HTN3
2chronic mucocutaneous candidiasis31.5IL10, AIRE
3bacterial vaginosis30.6MBL2, LTF
4aspergillosis30.5MBL2, CD79A
5leukemia30.5MBL2, STAT1, MPO, SH2D1A, CD9, CD79A
6acute leukemia30.4STAT1, MPO
7diabetes mellitus30.3CD79A, AIRE
8pneumonia30.2MBL2, MPO, DEFB1, DEFB4A, CD9, CD79A
9meningitis30.2CD79A, MBL2
10herpes simplex30.2CD79A, STAT1
11alopecia30.2AIRE
12hepatitis30.1STAT1, AIRE
13hypothyroidism30.1AIRE
14purpura30.1CD79A
15asthma30.0MBL2, STAT1, MPO, DEFB1, DEFB4A, CD79A
16tuberculosis30.0MBL2, STAT1, DEFB4A, CD9, CD79A, IL10
17systemic lupus erythematosus30.0MBL2, STAT1, MPO, LTF, CD79A, IL10
18peritonitis30.0MPO
19dermatitis30.0IL4, CD79A
20lupus erythematosus30.0CD79A
21alopecia areata30.0AIRE
22autoimmune polyendocrine syndrome30.0CARD9
23thyroiditis30.0MBL2, CD79A
24vasculitis29.9MBL2, MPO, SH2D1A, LTF, CD79A
25psoriasis29.9IL4, IL10, LTF, DEFB4A
26autoimmune hemolytic anemia29.9CD79A
27myasthenia gravis29.9IL4, IL10, AIRE
28cystic fibrosis29.7MBL2, MPO, DEFB1, DEFB103B, LTF, DEFB4A
29influenza29.7MBL2, STAT1, LTF, CD9, CD79A
30arthritis29.7STAT1, MPO, LTF, IL10, IL4, IL17RA
31eosinophilia29.7IL4, IL10, CD79A, MPO, STAT1, MBL2
32crohn's disease29.7LTF
33diarrhea29.7CD79A, LTF
34pancreatitis29.7MPO, LTF, IL10
35cryptosporidiosis29.7MBL2, CD79A
36lichen planus29.7DEFB4A
37neutropenia29.7MPO, MBL2
38vitiligo29.7AIRE
39deficiency anemia29.7CD79A
40churg-strauss syndrome29.7MPO, LTF
41toxoplasmosis29.7CD9, CD79A
42myeloma29.7IL4, CD79A, CD9, STAT1
43pemphigus29.7CD79A
44polyneuropathy29.7APCS, CD79A
45uveitis29.7IL4, IL10
46vulvovaginal candidiasis11.0
47vulvovaginitis11.0
48esophageal candidiasis10.8
49esophagitis10.8
50vaginitis10.8

Graphical network of the top 20 diseases related to Candidiasis:



Diseases related to candidiasis

Clinical Features for Candidiasis

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Drugs & Therapeutics for Candidiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Candidiasis

Drug clinical trials:

Search ClinicalTrials for Candidiasis

Search NIH Clinical Center for Candidiasis

Search CenterWatch for Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

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32MalaCards
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MalaCards organs/tissues related to Candidiasis:

32
Lung, Skin, Brain, Heart, T cells, Colon, Testes, Tongue, Liver, Kidney, Bone, Monocytes, Thyroid, Bone marrow, Myeloid, B cells, Thymus, Small intestine, Pituitary

Animal Models for Candidiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7SKAP2, CARD9, MBL2, APCS, STAT1, MPO
2MP:000539710.6AIRE, SH2D1A, MPO, STAT1, APCS, MBL2
3MP:000301210.5IL17RA, AIRE, STAT1
4MP:000537610.4CARD9, MBL2, STAT1, MPO, SH2D1A, AIRE

Publications for Candidiasis

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Sources:
50PubMed
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Articles related to Candidiasis:

(show top 50)    (show all 1555)
idTitleAuthorsYear
1
Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs. (23738751)
2013
2
Treatment of invasive candidiasis in neutropenic patients: systematic review of randomized controlled treatment trials. (23113686)
2013
3
Treatment of recurrent vulvo-vaginal candidiasis with sustained-released butoconazole pessary. (23268172)
2012
4
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity. (22024499)
2012
5
Anidulafungin for the treatment of candidaemia/invasive candidiasis in selected critically ill patients. (22404732)
2012
6
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis. (22543832)
2012
7
Non-invasive imaging of disseminated candidiasis in zebrafish larvae. (22872032)
2012
8
Treatment and prophylaxis of invasive candidiasis with anidulafungin, caspofungin and micafungin and its impact on use and costs: review of the literature. (21486732)
2011
9
Prediction of the clinical outcome in invasive candidiasis patients based on molecular fingerprints of five anti-Candida antibodies in serum. (20860995)
2011
10
Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. (21574164)
2011
11
Vulvovaginal Candidiasis Caused by Non-albicans Candida Species: New Insights. (21308556)
2010
12
Chronic mucocutaneous candidiasis and congenital susceptibility to Candida. (20859203)
2010
13
Miconazole (Oravig) for oropharyngeal candidiasis. (21116234)
2010
14
Incidence and anatomic localization of oral candidiasis in patients with AIDS hospitalized in a public hospital in Belo Horizonte, MG, Brazil. (19089255)
2008
15
Long-term use of fluconazole for verrucous plaques of cutaneous candidiasis in KID syndrome. (18573732)
2008
16
An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis. (17409603)
2007
17
Oral candidiasis and oral yeast carriage among institutionalised South African paediatric HIV/AIDS patients. (17295100)
2007
18
Risk indicators for HIV-associated jointly occurring oral candidiasis and oral hairy leukoplakia. (18240892)
2007
19
Review: inhaled corticosteroids increase risk of oral candidiasis, dysphonia, and pharyngitis in persistent asthma. (17905761)
2007
20
Oral candidiasis infections with limited clinical findings. (16884077)
2006
21
Probiotics for prevention of recurrent vulvovaginal candidiasis: a review. (16790461)
2006
22
Review: oral and intravaginal agents are equally effective for treatment of uncomplicated vulvovaginal candidiasis. (12093214)
2002
23
Delineation of the molecular defects in the AIRE gene in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients from Southern Italy. (11836330)
2002
24
Drugs for vulvovaginal candidiasis. (11151090)
2001
25
Immunology of chronic mucocutaneous candidiasis. (11215289)
2001
26
Pathogenesis, microbiological and clinical aspects of oral candidiasis (candidosis). (11791346)
2001
27
Liposomal amphotericin B (AmBisome) in the treatment of neonatal candidiasis in very low birth weight infants. (10961528)
2000
28
Cerebral vasculitis in chronic mucocutaneous candidiasis: autopsy case report. (11211056)
2000
29
Complete response of severe, refractory oral candidiasis to mouthwash containing lactoferrin and lysozyme. (11089630)
2000
30
Oropharyngeal candidiasis as a marker for esophageal candidiasis in patients with cancer. (9709877)
1998
31
Comparison of itraconazole and ketoconazole in HIV-positive patients with oropharyngeal or esophageal candidiasis. Human Immunodeficiency Virus Itraconazole Ketoconazole Project Group. (8874977)
1996
32
Vulvovaginal candidiasis: topical vs. oral therapy. (7754931)
1995
33
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. (8027327)
1994
34
Prevention of symptomatic recurrences of esophageal candidiasis in AIDS patients after the first episode: a prospective open study. (8122656)
1994
35
Vulvovaginal candidiasis refractory to treatment with fluconazole. (1587371)
1992
36
Esophageal candidiasis and immunodeficiency associated with acute HIV infection. (2905889)
1988
37
Chronic mucocutaneous candidiasis. (3334621)
1987
38
Rechallenge of patients who developed oral candidiasis or hoarseness with beclomethasone dipropionate. (3475563)
1987
39
Treatment of chronic atrophic oral candidiasis with ketoconazole (Nizoral): a case report. (3463686)
1986
40
Oral clotrimazole in the treatment of esophageal candidiasis. (7304661)
1981
41
Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis. (7383476)
1980
42
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
43
Topical clotrimazole treatment of chronic mucocutaneous candidiasis. (762637)
1979
44
Cimetidine in chronic mucocutaneous candidiasis. (507856)
1979
45
Vulvovaginal candidiasis treated with clotrimazole cream in seven days compared with fourteen-day treatment with miconazole cream. (360842)
1978
46
Chronic mucocutaneous candidiasis and alopecia areata. (4706468)
1973
47
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4192497)
1970
48
Esophageal candidiasis in a chimpanzee. (4916231)
1970
49
Hypersplenism due to disseminated candidiasis in a patient with acute leukemia. (5256261)
1969
50
Oral contraceptive medications and vulvovaginal candidiasis. (4185053)
1969

Genetic Variations for Candidiasis

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Expression for genes affiliated with Candidiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Candidiasis

Search GEO for disease gene expression data for Candidiasis.

Pathways for genes affiliated with Candidiasis

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53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Candidiasis

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.1MBL2, STAT1, DEFB103B, IL4, IL10, CD79A
2anti-fungal4411.0DEFB103B, APCS, HTN3, MBL2, DEFB4A, LTF
3cysteine4411.0MBL2, HTN3, IL4, CD79A, CD9, LTF
4paraffin4411.0MBL2, CD79A, DEFB4A, IL4, IL10, MPO
5rantes4411.0IL17RA, IL4, CD9, DEFB4A, MBL2, STAT1
6neopterin4411.0LTF, CD9, CD79A, IL10, IL4, MBL2
7polymyxin b4411.0MBL2, IL4, DEFB1, LTF, IL10
8ribavirin44 49 1113.0LTF, STAT1, MBL2, IL4, IL10
9histamine44 28 2413.0DEFB4A, MPO, CD79A, IL10, IL4, LTF
10fluconazole44 1112.0SH2D1A, LTF, HTN3, CD79A
11vegf4411.0IL4, IL10, CD79A, LTF, MPO, STAT1
12pentoxifylline44 1112.0MPO, CD9, LTF, IL4
13mannose4411.0CD9, CD79A, DEFB4A, MBL2, LTF
14con a4411.0MBL2, IL4, IL10, CD79A
15methacholine44 1111.9IL4, MPO, LTF, CD79A
16hypothiocyanite44 2411.9LTF, CD79A, MPO
17acidophilus4410.9MPO, IL10, IL4
18thiocyanate44 2411.9MPO, LTF, CD79A
19n acetylcysteine4410.9CD79A, STAT1, MPO, IL4, LTF
20hbd24410.9DEFB103B, DEFB4A, DEFB1
21tuberculin4410.9MBL2, IL10, CD79A
22sb 20358044 5911.9DEFB4A, AIRE, IL10, IL4, STAT1
23cyclophosphamide44 49 1112.9MBL2
24praziquantel44 1111.9CD79A, IL10, IL4
25polyethylene glycol4410.9CD79A, IL4, CD9, MPO
26mdms4410.9IL10, CD9, STAT1
27pmma4410.9CD79A, LTF, HTN3
28azathioprine44 49 2 1113.9IL10, CD79A, IL4, LTF
29retinoic acid44 2411.9CD9, LTF, CD79A, DEFB4A, DEFB1, MPO
30zymosan4410.9MBL2, LTF, MPO
31biotin44 11 2412.9IL4, IL10, CD79A, STAT1
32prednisolone44 28 1112.9IL10, MBL2, MPO, CD79A
33indomethacin44 59 28 1113.9LTF
34monomethyl fumarate4410.8IL4, IL10
35okt34410.8IL4, IL10, CD79A
36saquinavir44 1111.8SKAP2, CD9, APCS
37budesonide44 49 1112.8IL4, MPO, LTF
38lipoteichoic acid4410.8IL10, MBL2, DEFB4A
39thyroxine44 2411.8CD79A, MBL2, IL10, IL4
40polyinosinic-polycytidylic acid4410.8STAT1, IL10, IL4
41endotoxin4410.8STAT1, DEFB4A, LTF
42cyclosporin a44 28 5912.7CD79A, LTF, STAT1
43rolipram44 59 2812.7CD9
44hypoxanthine44 11 2412.7MPO, IL4, LTF
45dmso4410.7MPO, HTN3, IL10, STAT1
46betaseron4410.6IL10, IL4
47dextran sulfate4410.5MPO, CD9, LTF
48naphthol as-d chloroacetate4410.5LTF, MPO
49nacl4410.4MBL2, DEFB1, DEFB4A, LTF
50peptidoglycan44 2811.2MBL2, IL10, DEFB4A

GO Terms for genes affiliated with Candidiasis

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16Gene Ontology
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Cellular components related to Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6HTN3, APCS, DEFB1, DEFB4A, LTF, IL17F
2extracellular spaceGO:00561510.3IL4, IL17F, IL10, MPO, APCS, MBL2

Biological processes related to Candidiasis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274210.8IL10, LTF, DEFB4A, DEFB1, HTN3, MBL2
2negative regulation of growth of symbiont in hostGO:04413010.8MBL2, MPO, IL10
3regulation of interleukin-2 biosynthetic processGO:04507610.7IL17F, CARD9
4regulation of isotype switchingGO:04519110.7IL4, IL10
5regulation of interleukin-6 biosynthetic processGO:04540810.7IL17F, CARD9
6humoral immune responseGO:00695910.7SH2D1A, AIRE, LTF
7type 2 immune responseGO:04209210.6IL4, IL10
8B cell differentiationGO:03018310.6IL4, IL10, CD79A
9positive regulation of cytokine production involved in inflammatory responseGO:190001710.5IL17F, IL17RA
10B cell proliferationGO:04210010.5IL10, CD79A
11positive regulation of MHC class II biosynthetic processGO:04534810.4IL10, IL4
12negative regulation of nitric oxide biosynthetic processGO:04501910.2IL4, IL10

Products for genes affiliated with Candidiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet