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Candidiasis malady
2 drugs, 125 genes, 8 tissues, 693 related diseases, 17 phenotypes, 122 articles, clinical trials.

Summaries for Candidiasis

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6Disease Ontology, 2CDC, 44Wikipedia, 22MalaCards
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Disease Ontology: An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.6

MalaCards: Candidiasis, also known as systemic candidiasis, is related to vulvovaginal candidiasis and chronic mucocutaneous candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types and Th17 Differentiation. The drugs flucytosine and natamycin and the compounds cyclophosphamide and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and colon, and related mouse phenotypes are respiratory system and liver/biliary system.

CDC: Photomicrograph of the fungus Candida albicans. Credit: CDC/Dr. Godon Roberstad2

Wikipedia: Candidiasis or thrush is a fungal infection (mycosis) of any of the Candida species (all yeasts), of...44 more...

Aliases & Descriptions for Candidiasis

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2CDC, 6Disease Ontology, 7diseasecard, 8DISEASES, 32Novoseek , 43UMLS, 30NIH Rare Diseases, 40SNOMED-CT, 19ICD9CM, 24MeSH, 27NCIt
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Aliases & Descriptions:

candidiasis 6 7 8 32 43
systemic candidiasis 6 30 43
disseminated candidiasis 6 32
disseminated candidiasis (disorder) 6
systemic candida infections 30

External Ids:

ICD9CM19 112, 112.9
SNOMED-CT40 187478002, 187005005, 187024008 154403005, 78048006, more

Related Diseases for Candidiasis

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13GeneCards, 14GeneDecks
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Diseases related to candidiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 690)
idRelated DiseaseScoreTop Affiliating Genes
1vulvovaginal candidiasis34.8LAP3, CD79A, IL4, MBL2, F2, NLRP3
2chronic mucocutaneous candidiasis34.7CLEC6A, MPO, CD79A, CD86, CD83, IL10
3oral candidiasis34.2SH2D1A, MUC7, MT-CYB, B2M, MPO, CD9
4vulvovaginitis32.3LAP3, CD79A, IL10, IL13, IL4, IL5
5autoimmune polyendocrine syndrome type 132.2IL17A, AIRE, TPH1, CYP21A2, PFKL
6bacterial vaginosis30.0LAP3, IL10, IL4, MBL2, LTF, TLR2
7vaginitis28.5SH2D1A, BTD, LAP3, CD79A, CD9, INS
8hypothyroidism28.5IFNB1, TPO, TSHR, TG
9candida glabrata28.2APCS, HTN3, SKAP2, CSF2
10hypothyroidism, autoimmune27.5IL2RA, AIRE, TPO
11polyneuropathy27.4B2M, CD79A, CD4, CD40LG, INS, IL10
12cutaneous t cell lymphoma27.1IL2, IL2RA, IL4, IL5, IL7, IFNG
13oral lichen planus26.7CD83, MIF, FCGR2A, FCGR3B, IL10, IL18
14panniculitis26.6IL2RA, IGHE, IFNB1, IFNG, AIRE, CSF3
15autoimmune thyroiditis26.3IL2RA, IL4, IFNG, AIRE, TPO, PTPN22
16immunodeficiency26.0MOG, CD79A, CD4, CD40LG, MIF, INS
17herpes simplex25.7CD79A, CD86, CD4, CD40LG, CD83, MIF
18lichen planus25.3CD79A, CD4, CD83, MIF, INS, FCGR2A
19acute leukemia25.3B2M, MPO, CD79A, CD86, CD40LG, CD9
20atopy24.4MPO, CD79A, MIF, IL10, IL13, IL18
21duodenitis23.6MT-CYB, B2M, MPO, CD79A, CD40LG, MIF
22thyroiditis21.1MT-CYB, B2M, MPO, CD79A, CD86, CD4
23blindness20.3B2M, AVPR2, MPO, MOG, CD79A, CD40LG
24squamous cell carcinoma19.1B2M, MPO, CD79A, CD86, CD4, CD9
25diabetes mellitus19.0BTD, LAP3, B2M, MPO, CD79A, CD86
26leukemia18.2SH2D1A, BTD, CHIT1, MUC7, B2M, MPO
27hepatitis17.3RFX2, BTD, CLEC7A, LAP3, B2M, AVPR2
28carcinoma14.4BTD, RABAC1, MUC7, MT-CYB, LAP3, B2M
29primary systemic mycosis14.1CLEC7A, CD79A, IL10, IL4
30trachoma14.1CD79A, IL10, IL17A, IL4, MBL2
31primary sclerosing cholangitis14.0MPO, AIRE, LTF, SLPI, GGT1
32tonsillitis14.0CD79A, DEFB1, DEFB4A
33microsporidiosis14.0CNOT8, CD4, LTF, DEFB4A, DEFA5
34tuberculosis14.0IL10, IL4, MBL2, IFNG, TLR4, TIRAP
35extrapulmonary tuberculosis14.0IL10, MBL2, IFNG, TLR2, TIRAP
36lepromatous leprosy14.0IL10, IL2, IL4, IFNG, TLR2
37aids dementia complex14.0B2M, CD4, CD9, IL10, IFNG
38cystic fibrosis lung disease14.0MPO, IL10, IL17A, MBL2, TLR2
39periodontitis14.0MPO, FCGR3A, IL10, IL17A, LTF, TLR2
40hypersensitivity vasculitis14.0MPO, CD79A, FCGR3B
41intrauterine infections13.9IL10, IL4, IFNG, LTF
42herpes zoster13.9CD79A, CD4, CD9, FCGR3A, IL10, IL4
43coccidiosis13.9CD4, IL17D, IL2, IFNG
44opportunistic bacterial infectious disease13.9B2M, CD4, CD9, IL7, IFNG, DEFB4A
45multidrug-resistant tuberculosis13.9IL10, IL2, IL4, IFNG
46lymphatic system disease13.9CD79A, CD4, IL2, IFNG
47natural killer cell leukemia13.9MPO, CD79A, IL7, IFNG
48coccidioidomycosis13.9CLEC7A, CD4, IL10, MBL2, MAN1C1, IFNG
49neisseria meningitidis infection13.9FCGR2A, MBL2, TLR2, TLR4
50gaucher's disease13.9CHIT1, IL18, MBL2, F2, HSP90AA1, PSAP

Graphical network of the top 20 diseases related to candidiasis:



Graphical network of diseases related to candidiasis

Clinical Features for Candidiasis

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Drugs & Therapeutics for Candidiasis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 flucytosine, natamycin

Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

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22MalaCards
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MalaCards organs/tissues related to candidiasis:

22
Brain, Heart, Colon, Lung, Thyroid, Skin, T cells, Pituitary

Phenotypes for genes affiliated with Candidiasis

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25MGI
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MGI Mouse Phenotypes related to candidiasis:

25 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.1GAD2, GAD1, ELK3, CYBA, PTPN22, TPH1
2liver/biliary system phenotypeMP:00053709.7PSAP, TLR4, TLR2, NLRP3, PTPN22, AIRE
3endocrine/exocrine gland phenotypeMP:00053799.7GGT1, GAD2, PSAP, TLR3, TLR2, TMPO
4digestive/alimentary phenotypeMP:00053819.4AIRE, TMPO, CYP51A1, KRT17, TLR2, STAT1
5skeleton phenotypeMP:00053909.4STAT1, PSAP, CSF2, GAD1, CYP51A1, AKR1A1
6reproductive system phenotypeMP:00053899.3TSHR, TLR3, TLR4, PSAP, CSF2, NLRP3
7no phenotypic analysisMP:00030129.1IFNB1, AIRE, CYP51A1, CYP3A43, STAT1, IL23A
8tumorigenesisMP:00020068.9AIRE, TRIM24, CYP1B1, TLR2, TLR3, TLR4
9immune system phenotypeMP:00053878.7SH2D1A, F2, HSP90AA1, CASP12, AKR1A1, AIRE
10cellular phenotypeMP:00053846.6TMPO, TRIM24, AIRE, AKR1A1, CASP12, HSP90AA1
11hematopoietic system phenotypeMP:0005397INFIL5, APCS, APRT, IGHE, AKR1A1, TMPO
12homeostasis/metabolism phenotypeMP:0005376INFCCL3, CYP17A1, NLRP3, LTF, ELK3, TSHR
13mortality/agingMP:0010768INFTLR4, TLR2, TSHR, ELK3, KRT17, NLRP3
14growth/size phenotypeMP:0005378INFTLR4, TSHR, NLRP3, PTPN22, TPO, TG
15behavior/neurological phenotypeMP:0005386INFTLR2, TSHR, ELK3, CYP17A1, CYBA, TLR3
16renal/urinary system phenotypeMP:0005367INFGAPDH, PSAP, NLRP3, AKR1A1, APRT, APCS
17integument phenotypeMP:0010771INFTMPO, NLRP3, KRT17, TLR2, TLR4, PVRL1

Publications for genes affiliated with Candidiasis

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35PubMed
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Articles related to candidiasis:

(show top 50)    (show all 122)
idTitleAuthorsYearAffiliating Genes
1Clinical and microstructural aberrations of enamel of deciduous and permanent teeth in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. (19246027)Pavlic A.... Waltimo-SirAcn J.2009AIRE
2The autoimmune polyendocrinopathy-candidiasis-ectoder mal dystrophy or autoimmune polyglandular syndrome type 1. (19676003)Lankisch T.O.... Strassburg C.P.2009AIRE
3Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. (19254587)Lev-Sagie A.... Witkin S.S.2009NLRP3
4Chronic inflammatory demyelinating polyneuropathy as a possible novel component of autoimmune poly-endocrine-candidiasis-ectodermal dystrophy. (18461357)Valenzise M.... De Luca F.2009AIRE
5Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. (19196253)Hong M.... Lilic D.2009AIRE, PVRL1
6Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers. (18274776)De Luca F.... Betterle C.2008AIRE, TPH1
7A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. (18320920)Bhui R.D.... Nadeau K.C.2008AIRE
8Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients treated with radiotherapy for head and neck cancer. (18044772)Bensadoun R.J.... Attali P.2008MOG
9Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22. (18615114)Eyerich K.... Traidl-Hoffmann C.2008IL17A, IL22, IL17D
10Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. (17470593)Giraldo P.C.... Witkin S.S.2007MBL2
11Pituitary autoantibodies in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (17465338)O'Dwyer D.T.... Crock P.A.2007AIRE
12Altered, but not diminished specific T cell response in chronic mucocutaneous candidiasis patients. (17960405)Eyerich K.... Traidl-Hoffmann C.2007IFNG, IL10
13Single-dose fluconazole for vulvovaginal candidiasis: impact on prothrombin time in women taking warfarin. (16449117)Turrentine M.A.2006F2
14Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. (15825027)Babula O.... Witkin S.S.2005IL4, MBL2
15Association between atopy and recurrent vaginal candidiasis. (16178872)Neves N.A.... Carvalho E.M.2005IL5, IGHE
16NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis- ectodermal dystrophy (APECED) disease. (15649886)Bottomley M.J.... Musco G.2005AIRE
17Antifungal activity of human salivary mucin-derived peptide, MUC7 12-mer, in a murine model of oral candidiasis. (16650064)Muralidharan R.... Bobek L.A.2005MUC7
18Characterization of the humoral immune response to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and/or type 1 diabetes. (16322397)Ronkainen M.S.... Knip M.2005GAD2
19Chronic mucocutaneous candidiasis and primary hypothyroidism in two families. (15290270)Myhre A.G.... Husebye E.S.2004TPO
20Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies. (15378761)Pitarch A.... Gil C.2004AKR1A1
21Development of murine experimental model for candidiasis and its application (15550920)Abe S.2004LTF
22Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. (15039315)Chattopadhyay A.... Shugars D.C.2004SLPI
23Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria? (12843157)Buzi F.... Notarangelo L.D.2003INS
24A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1. (12774035)Mangino M.... Dallapiccola B.2003CANDN1
25Lupus-like panniculitis in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (12951636)FA1chtenbusch M.... Manns M.P.2003AIRE
26New sensitive method for the measurement of lysozyme and lactoferrin to explore mucosal innate immunity. Part II: time-resolved immunofluorometric assay used in HIV patients with oral candidiasis. (12666997)Laibe S.... Meillet D.2003LTF
27The syndrome of chronic mucocutaneous candidiasis with selective antibody deficiency. (12602677)Kalfa V.C.... Stiehm E.R.2003CD79A
28Reversible metaphyseal dysplasia, a novel bone phenotype, in two unrelated children with autoimmunepolyendocrinopathy-candidiasis-ectodermal dystrophy: clinical and molecular studies. (14557425)Harris M.... Walker J.2003AIRE
29Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects. (11807692)Cassone A.... Cauda R.2002SH2D1A
30Immunohistochemical study on expression of alpha-defensin and beta-defensin-2 in human buccal epithelia with candidiasis. (11936455)Sawaki K.... Sugahara T.2002DEFB4A
31Nonspecific secretory immunity in HIV-infected patients with oral candidiasis. (12439202)Bard E.... Meillet D.2002LTF
32A novel missense mutation of AIRE gene in a patient with autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED), accompanied with progressive muscular atrophy: case report and review of the literature in Japan. (12625412)Sato K.... Takano K.2002AIRE
33Familial chronic nail candidiasis with ICAM-1 deficiency: a new form of chronic mucocutaneous candidiasis. (12205111)Zuccarello D.... Dallapiccola B.2002CANDN1
34The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. (11992285)Netea M.G.... Kullberg B.J.2002TLR4
35New perspectives on the immunology of chronic mucocutaneous candidiasis. (11964914)Lilic D.2002IL10
36Characterization of the cellular immune function of patients with chronic mucocutaneous candidiasis. (11207655)de Moraes-Vasconcelos D.... Duarte A.J.2001MPO
37Antifungal antibodies: a new approach to the treatment of systemic candidiasis. (11566001)Matthews R.... Burnie J.2001HSP90AA1
38Oral pseudomembranous candidiasis, herpes simplex virus-1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte-macrophage colony-stimulating factor (GM-CSF) mouthwash. (11545238)Nicolatou-Galitis O.... Velegraki A.2001CSF2
39Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED). (11156688)Halonen M.... Kolmer M.2001AIRE
40A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis. (11600535)Cetani F.... Marcocci C.2001AIRE
41Autoimmunity to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (10691912)Klemetti P.... Vaarala O.2000GAD1
42Myeloperoxidase deficiency associated with atypical oral candidiasis: A clinical report. (10479248)Edgerton M.1999MPO
43Local production of chemokines during experimental vaginal candidiasis. (10531235)Saavedra M.... Fidel P.L.1999CCL5, CCL3, CXCL2
44In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis. (10225911)Naglik J.R.... Agabian N.1999DEFB4A
45Chronic vaginal candidiasis responsive to biotin therapy in a carrier of biotinidase deficiency. (9764646)Strom C.M.... Levine E.M.1998BTD, HLCS
46A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients. (9856486)Rosatelli M.C.... Antonarakis S.E.1998AIRE
47Enhanced IgE response to Candida albicans in postoperative invasive candidiasis. (8732243)Savolainen J.... Viander M.1996CD40LG
48Antifungal combination therapy with granulocyte colon y-stimulating factor and fluconazole in experimental disseminated candidiasis. (8565989)Graybill J.R.... Luther M.1995CSF3
49Immunohistochemical study of in vivo and in vitro IgA coating of candida species in vulvovaginal candidiasis. (8039782)Bohler K.... Reinthaller A.1994CD79A
50Invasive candidiasis during granulocytopenia. (8265854)Anaissie E.... Pinczowski H.1993IL3

Expression for genes affiliated with Candidiasis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Candidiasis

Pathways for genes affiliated with Candidiasis

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37R&D Systems, 20KEGG, 36QIAGEN, 38Reactome, 34PharmGKB, 41Thomson Reuters
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Pathways related to candidiasis according to GeneDecks:

(show top 50)    (show all 89)
idPathwayScoreTop Affiliating Genes
1IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types3710.6TLR4, TLR3, TLR2, IFNG, IL4, IL22
2Th17 Differentiation3710.5CD86, TLR4, TLR3, IL17A, IL23A, IL22
3Th1 Differentiation3710.5TLR3, IL10, TLR4, IL2, IL18, IFNG
4Tuberculosis2010.4IFNB1, TLR2, TLR4, TIRAP, STAT1, IFNG
5Leishmaniasis2010.3STAT1, TLR2, CYBA, IFNG, IL10, FCGR3B
6THC Differentiation Pathway3610.3IL2, IFNG, IL10, IL4, IL2RA, IL18
7OX40 Pathway3610.1IL13, IL4, IL5
8NOD-like receptor signaling pathway2010.1PSTPIP1, CXCL2, CARD9, HSP90AA1, IL18, CCL5
9Toll-like receptor signaling pathway2010.0CD86, IFNB1, TLR2, TLR3, TLR4, TIRAP
10Measles209.9IFNG, TLR4, IFNB1, IL4, TLR2, SH2D1A
11Cytokine Network369.9IFNG, IFNB1, IL5, IL4, IL3, IL2
12Rheumatoid arthritis209.9TLR4, IL18, IL17A, CD86, TLR2, IL23A
13Allograft rejection209.8IL5, IL4, IL2, IL10, CD40LG, CD86
14NFAT Signaling and Lymphocyte Interactions369.6IL2, CCL3, IL13, CD4, IL22, IL23A
15Immune System389.6CD79A, FCGR3A, IL18, IL3, IL5, IFNG
16Carbamazepine Pathway, Pharmacokinetics349.5CYP3A5, CYP2B6, CYP2A6, CYP3A4
17Akt Signaling369.5PFKL, HSP90AA1, CCL5, CSF2, CD4, IL10
18Cytokine production by Th17 cells in CF419.4IL23A, IL17F, CSF2, CSF3, IL17RA, TLR4
19PGC1Alpha Pathway369.4CCL5, IL18, CCL3, IL7, IL5, IL4
20Regulation of eIF4 and p70S6K369.4IL3, IL18, IL2, IL22, IL23A, CCL5
21Autoimmune thyroid disease209.3IL5, TG, TPO, IL4, IL2, IL10
22Cytokine production by Th17 cells in CF (Mouse model)419.2IL17F, IL17RA, IL23A, TLR4, CSF2, IL17A
23T cell receptor signaling pathway209.1CSF2, IL5, IL4, IL2, IL10, CD4
24Cyclophosphamide Pathway, Pharmacokinetics349.1CYP2C19, CYP2A6, CYP3A4, CYP2B6, CYP3A5
25Glucocorticoid Receptor Signaling369.1HSP90AA1, CCL5, CCL3, IL7, IL2RA, IL5
26Malaria209.0TLR4, CSF3, TLR2, CD40LG, IL10, IL18
27Asthma209.0IL3, CD40LG, IL10, IL13, IL4, IL5
28TGF-Beta Pathway369.0IL13, IL18, IL10, CD4, IL2, IL22
29JAK-STAT Pathway368.9IL22, IL2, IL23A, IL2RA, STAT1, F2
30MAPK Family Pathway368.9IL13, IL10, CD4, IL2, IL22, IL3
31SOCS Pathway368.8STAT1, CCL5, IL18, CD4, INS, IL10
32RAR-Gamma-RXR-Alpha Degradation368.8IL22, IL2, IL23A, IL3, IL7, CCL3
33Linoleic acid metabolism208.7PLB1, CYP2J2, CYP3A5, CYP2C19, CYP3A43, CYP3A4
34Biological oxidations388.7CYP2J2, CYP1B1, CYP3A4, CYP3A43, CYP2A6, CYP3A5
35Tec Kinases Signaling368.7IL2, IL10, CD4, TLR2, IL4, IL18
36Hematopoietic cell lineage208.5CSF2, CSF3, IL2RA, IL4, CD4, CD9
37Jak-STAT signaling pathway208.2IL10, IL7, IL13, IL2, IL22, IL23A
38all-trans-Retinoic Acid Signaling in Brain368.2IL5, IL7, CCL3, CCL5, CXCL2, CSF2
39PEDF Induced Signaling368.2IL2, IL22, IL23A, IL3, IL4, IL5
40IL-6 Pathway368.2IL10, CCL3, IL13, IL18, CSF3, CSF2
41Endothelin-1 Signaling Pathway368.1IL7, IL4, CXCL2, CSF2, CSF3, CCL5
42MIF Regulation of Innate Immune Cells368.1IL13, MIF, IL10, IL18, IL2, IL22
43MIF Mediated Glucocorticoid Regulation368.0CXCL2, CSF3, CSF2, TLR4, CCL5, MIF
44STAT3 Pathway367.8IL23A, IL7, IL18, CCL3, IL13, IL10
45ERK Signaling367.8STAT1, CSF3, IL4, IL5, IL7, CCL3
46PAK Pathway367.8IL7, IL3, CSF3, CSF2, CXCL2, CCL5
47p38 Signaling367.7CD4, IL10, CSF3, CXCL2, IL7, CCL5
48Antioxidant Action of Vitamin-C367.7IL22, IL23A, CXCL2, IL2RA, IL3, IL4
49Metabolic pathways207.4CYP17A1, CYP3A43, PFKL, CYP2A6, CYP2B6, CYP2C19
50Cytokine-cytokine receptor interaction207.2CD40LG, IL10, IL13, IL17A, IFNG, IFNB1

Compounds for genes affiliated with Candidiasis

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to candidiasis according to GeneDecks:

(show top 50)    (show all 426)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.9MBL2, LTF
2glucose32 10.6BTD, CLEC7A, MT-CYB, LAP3, MIF, TMPO
3polyinosinic-polycytidylic acid32 9.8CD83, IL10, IL18, IL2, IL4, IL5
4heparin32 9 18 9 12.6MPO, CD79A, CD4, FCGR2A, IL3, IL7
5pge232 9.6CD86, CD4, CD83, IL13, IL17A, IL23A
6ionomycin32 9.4IL3, IL5, IL7, CCL3, TSHR, CSF2
7endotoxin32 9.4CD86, MIF, IL18, CCL3, IFNB1, LTF
8mannose32 9.0CLEC7A, CHIT1, CD79A, CD86, CD4, CD83
9fluconazole32 9 9 10.9SH2D1A, CD79A, CDR1, IL3, HTN3, CYP51A1
10poly(i-c)32 8.9IL18, IL3, IL4, IL5, CCL3, CCL5
11il-1232 8.7CD86, CD40LG, IL10, IL13, IL18, IL2
12tarc32 8.6CD4, IL10, IL13, IL18, IL4, IL5
13methimazole32 9 9 10.4IL13, IL2RA, CYP3A4, CYP2A6, CYP2B6, CYP2C19
14fluticasone propionate32 42 9 9 11.4MPO, IL13, IL4, IL5, CCL5, IGHE
15il 1032 8.3IL10, IL13, IL18, IL2, IL2RA, IL3
16cholesterol32 9 18 9 11.2B2M, CD4, CD9, INS, FCGR2A, FCGR3A
17ribavirin32 34 9 9 11.2CD40LG, IL10, IL18, IL2, IL3, IL4
18gm-csf32 8.2IL10, IL13, IL18, IL2, IL3, IL4
19cysteine32 8.2BTD, MUC7, LAP3, CD79A, CD4, CD40LG
20nadph32 18 9.1FCGR3B, CYP51A1, CYP1B1, CYP3A4, CYP3A43, CYP2A6
21anti-fungal32 8.1MUC7, CD79A, CDR1, CD40LG, IL5, APCS
22amphotericin b32 8.0IL13, IL4, IL5, CCL5, IFNG, HTN3
23praziquantel32 9 9 10.0CD79A, CD40LG, IL10, IL13, IL4, IL5
24thyroxine32 18 8.9B2M, CD79A, CD40LG, INS, IL10, IL13
25indomethacin32 9 9 9.9B2M, MPO, CD79A, CD40LG, IL13, IL17A
26oxygen32 18 8.9MT-CYB, MPO, MOG, MIF, FCGR2A, FCGR3A
27vegf32 7.8LAP3, MPO, CD40LG, MIF, MBL2, CCL3
28calcitriol32 42 9 18 9 11.8B2M, CD83, IL13, IL2, IL2RA, IL3
29lipid32 7.8CHIT1, MT-CYB, LAP3, MOG, CD4, CD9
30histamine32 18 8.7MPO, CD79A, CD86, CD40LG, FCGR2A, IL10
31glutamate32 7.6LAP3, CD79A, CD4, INS, IL7, CCL3
32zidovudine32 9 9 9.5B2M, CD4, CD9, IL10, IL2, IL3
33formaldehyde32 18 8.4B2M, MPO, CD79A, CD4, CD40LG, IL2RA
34creatinine32 7.4MT-CYB, LAP3, B2M, MPO, CD79A, CD40LG
35estrogen32 7.4MIF, INS, IL18, IGHE, F2, HSP90AA1
36genistein32 9 18 9 10.3B2M, CD4, CD40LG, CD9, MIF, FCGR3B
37h2o232 7.1MT-CYB, LAP3, MPO, CD79A, MIF, FCGR2A
38tacrolimus32 34 9 9 10.1CD79A, CD86, INS, IL10, IL13, IL17A
39lactate32 6.8BTD, LAP3, B2M, MPO, CD79A, CD40LG
40rantes32 6.8CD4, CD40LG, CD9, MIF, IL10, IL13
41cycloheximide32 6.6MT-CYB, B2M, CD86, CD4, CD83, IL10
42prednisolone32 9 9 8.6MPO, CD79A, FCGR2A, FCGR3B, IL10, IL13
43hydrocortisone32 9 9 8.5MIF, INS, IL10, IL13, IL2, IL3
44cyclosporin a32 42 7.2B2M, CD86, CD83, IL10, IL13, IL17A
45serine32 5.8BTD, MUC7, MT-CYB, LAP3, B2M, MPO
46testosterone32 9 18 9 8.2B2M, CD79A, CD40LG, INS, IL18, IL2RA
47retinoic acid32 42 18 5.8MUC7, LAP3, B2M, MPO, CD79A, CD40LG
48dexamethasone32 42 34 9 9 7.4CLEC7A, CD79A, CD86, CD40LG, CD83, MIF
49alanine32 INFBTD, MT-CYB, LAP3, B2M, , CD79A
50tyrosine32 INFSH2D1A, BTD, CLEC7A, , CD86, CD4

GO Terms for genes affiliated with Candidiasis

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12Gene Ontology
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Cellular components related to candidiasis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.6DEFA5, DEFB4A, DEFB1, F2, INS, MUC7
2external side of plasma membraneGO:0098979.4IL13, IL17A, IL4, IFNG, TLR2, TLR4
3endoplasmic reticulum membraneGO:0057897.8CYP2J2, CYP3A5, CYP21A2, CYP17A1, CYP4X1, CYP2C19
4extracellular regionGO:0055767.1LTF, F2, HTN3, IFNG, IFNB1, CCL5
5extracellular spaceGO:0056156.5BTD, IL5, IL7, APCS, MBL2, CCL3

Biological processes related to candidiasis according to GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.8TIRAP, TLR2, IFNG, MBL2, IL10
2type 2 immune responseGO:04209210.7IL10, IL18, IL4
3defense response to bacteriumGO:04274210.7DEFA5, DEFB4A, DEFB1, TLR4, TLR3, LTF
4humoral immune responseGO:00695910.7LTF, AIRE, IFNG, IFNB1, IL7, CD83
5positive regulation of interleukin-8 productionGO:03275710.6TIRAP, TLR4, TLR3, TLR2, IL18
6positive regulation of activated T cell proliferationGO:04210410.6IL18, IL2, IL23A, IL4
7defense response to virusGO:05160710.6TLR3, NLRP3, CARD9, IFNG, IFNB1, CD86
8positive regulation of isotype switching to IgG isotypesGO:04830410.6IFNG, IL4, IL2
9positive regulation of chemokine productionGO:03272210.6TLR4, TLR3, TLR2, IL18
10positive regulation of cytokine production involved in inflammatory responseGO:190001710.6IL17RA, IL17F, IL17A
11positive regulation of tissue remodelingGO:03410510.5IL23A, IL2, IL18
12positive regulation of osteoclast differentiationGO:04567210.5IFNG, CCL5, IL23A, IL17A
13positive regulation of NF-kappaB import into nucleusGO:04234610.5TLR4, IL23A, TLR2, TLR3
14positive regulation of tumor necrosis factor productionGO:03276010.5TIRAP, TLR4, TLR3, TLR2, CARD9, IFNG
15cellular response to lipoteichoic acidGO:07122310.5TIRAP, TLR4, TLR2
16positive regulation of interleukin-23 productionGO:03274710.4CSF2, IFNG, IL17RA, IL17A
17positive regulation of inflammatory responseGO:05072910.4TLR4, TLR3, TLR2, CCL3, IL23A, IL2
18negative regulation of osteoclast differentiationGO:04567110.4CCL3, TLR3, TLR4, IL4
19lipopolysaccharide-mediated signaling pathwayGO:03166310.4STAT1, TLR4, TLR2, CCL5, CCL3, IL18
20positive regulation of MHC class II biosynthetic processGO:04534810.3TLR4, IFNG, IL4, IL10, CD40LG
21B cell proliferationGO:04210010.3CD79A, CD40LG, IL10, IFNB1
22positive regulation of interleukin-10 productionGO:03273310.3TLR4, IL4, IL23A, CD83, CD40LG
23innate immune responseGO:04508710.3TLR2, TLR3, TLR4, TIRAP, DEFB1, DEFB4A
24acute-phase responseGO:00695310.3F2, MBL2, APCS, IL22, INS
25negative regulation of interleukin-17 productionGO:03270010.3TLR4, TLR2, IFNG
26cellular response to interferon-gammaGO:07134610.2IL18, CCL3, CCL5, TLR3
27positive regulation of nitric oxide biosynthetic processGO:04542910.2TLR4, TLR2, HSP90AA1, IFNG, INS
28positive regulation of interferon-gamma productionGO:03272910.2TLR4, IL23A, IL2, IL18, CD40LG
29positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2CSF2, IL4, IL3, IL23A, IL2
30cell surface receptor signaling pathwayGO:00716610.1TIRAP, F2, IFNG, IFNB1, IL2RA, IL17RA
31positive regulation of interleukin-12 productionGO:03273510.1TIRAP, TLR4, TLR3, TLR2, IFNG, IL23A
32positive regulation of cytokine secretionGO:05071510.1TLR2, IL10, INS, MIF, CLEC6A
33B cell differentiationGO:03018310.1TSHR, IL4, IL10, CD40LG, CD79A
34response to drugGO:0424939.6GAD2, GAD1, CYP17A1, CARD9, IFNG, CCL5
35positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5TLR4, IL5, IL3, INS, MIF, CD4
36positive regulation of B cell proliferationGO:0308909.5TIRAP, TLR4, IL7, IL5, IL4, IL2
37exogenous drug catabolic processGO:0427389.4CYP3A4, CYP2A6, CYP2B6, CYP2C19
38cell-cell signalingGO:0072679.0IL22, IL3, IL7, CCL3, CCL5, TSHR
39inflammatory responseGO:0069548.9CXCL2, IL17F, IL17D, IL17A, IL13, IL10
40steroid metabolic processGO:0082028.9PLB1, CYP3A5, CYP21A2, CYP17A1, CYP2C19, CYP2B6
41oxidation-reduction processGO:0551148.9CYP2C19, CYP2B6, CYP3A4, CYP1B1, MPO, CYBA
42xenobiotic metabolic processGO:0068058.4CYP17A1, CYP21A2, CYP3A5, CYP2J2, GGT1, CYP2C19
43immune responseGO:0069557.8CSF3, CSF2, CXCL2, IL2, IL18, IL17A
44small molecule metabolic processGO:0442817.3CYP2C19, CYP17A1, CYP21A2, CYP3A5, CYP2J2, PLB1
45I-kappaB kinase/NF-kappaB cascadeGO:007249INFTIRAP, TLR4, TLR3, CARD9,
46positive regulation of cell proliferationGO:008284INFCSF3, CSF2, TSHR, F2, IL7, IL3

Molecular functions related to candidiasis according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1aromatase activityGO:0703309.8CYP2J2, CYP3A5, CYP4X1, CYP3A43, CYP1B1
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:0167129.3CYP2B6, CYP2A6, CYP3A4, CYP1B1
3steroid hydroxylase activityGO:0083959.0CYP21A2, CYP2C19, CYP3A4
4monooxygenase activityGO:0044978.8CYP3A5, CYP2C19, CYP2B6, CYP3A43, CYP3A4, CYP1B1
5oxygen bindingGO:0198258.8CYP3A5, CYP17A1, CYP2C19, CYP3A4, CYP1B1
6growth factor activityGO:0080838.5CSF3, CSF2, F2, IL7, IL5, IL4
7enzyme bindingGO:0198998.1CD4, CYP3A4, CYP2A6, CYP2C19, STAT1, CSF3
8heme bindingGO:0200378.1CYBA, CYP4X1, CYP17A1, CYP21A2, CYP3A5, CYP2J2
9iron ion bindingGO:0055068.1CYP2J2, CYP3A5, CYP21A2, CYP17A1, CYP4X1, CYP2C19
10electron carrier activityGO:0090558.0CYBA, CYP4X1, CYP17A1, CYP21A2, CYP3A5, CYP2J2
11cytokine activityGO:0051257.7CD40LG, IL3, IL4, IL5, IL7, IFNB1

Sources for Candidiasis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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