MCID: CND004
MIFTS: 54

Candidiasis malady

Genetic diseases, Rare diseases, Infectious diseases, Immune diseases categories

Summaries for Candidiasis

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Disease Ontology:9 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.

MalaCards based summary: Candidiasis, also known as systemic candidiasis, is related to chronic mucocutaneous candidiasis and oral candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Cytokine production by Th17 cells in CF and IL-17 Family Signaling Pathways. The drug flucytosine and the compounds flagellin and zymosan have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and lung, and related mouse phenotypes are digestive/alimentary and respiratory system.

CDC:3 Photomicrograph of the fungus Candida albicans

Wikipedia:63 Candidiasis is a fungal infection due to any types of Candida (a type of yeast). When it affects the... more...

Aliases & Classifications for Candidiasis

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Candidiasis, Aliases & Descriptions:

Name: Candidiasis 9 11 43 3 60
Systemic Candidiasis 9 41 60
 
Disseminated Candidiasis 9 43
Systemic Candida Infections 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Infectious diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:1508
ICD9CM27 112, 112.9
MeSH33 D002177
NCIt38 C26711
ICD1025 B37, B37.9

Related Diseases for Candidiasis

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Diseases in the Candidiasis family:

Candidiasis, Familial, 8 Candidiasis, Familial, 3
Candidiasis, Familial, 6, Autosomal Dominant Candidiasis, Familial, 2, Autosomal Recessive
Candidiasis, Familial, 4, Autosomal Recessive Candidiasis, Familial, 5, Autosomal Recessive

Diseases related to Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 214)
idRelated DiseaseScoreTop Affiliating Genes
1chronic mucocutaneous candidiasis32.3STAT1
2oral candidiasis31.6DEFB4A, HTN3, LTF
3autoimmune polyendocrine syndrome30.7CARD9
4coccidioidomycosis30.4CLEC7A
5hepatitis30.2LTF, STAT1
6pneumonia30.2IL17F, DEFB1, DEFB4A
7tuberculosis30.1DEFB4A, CLEC7A, STAT1
8vasculitis29.9LTF, SH2D1A
9acne29.9DEFB1, DEFB4A
10asthma29.8DEFB4A, DEFB1, STAT1, IL17F
11arthritis29.6LTF, IL17RA, STAT1
12cystic fibrosis29.3DEFB4A, DEFB1, LTF
13vulvovaginal candidiasis11.1
14vulvovaginitis11.1
15esophageal candidiasis10.9
16esophagitis10.9
17vaginitis10.8
18neonatal candidiasis10.7
19bacterial vaginosis10.5
20trichomoniasis10.5
21leukoplakia10.4
22blindness10.4
23candida glabrata10.4
24aspergillosis10.4
25leukemia10.4
26candidiasis, familial, 6, autosomal dominant10.4
27candidiasis, familial, 2, autosomal recessive10.3
28acquired immunodeficiency syndrome10.3
29thymoma10.3
30autoimmune polyendocrine syndrome type 110.3
31candidiasis, familial, 5, autosomal recessive10.3
32androgen insensitivity, partial, with or without breast cancer10.3
33invasive aspergillosis10.3
34oral hairy leukoplakia10.3
35candidal paronychia10.3
36acute leukemia10.2
37meningitis10.2
38ulcerative colitis10.2LTF
39candidiasis, familial, 810.2
40candidiasis, familial, 4, autosomal recessive10.2
41herpes simplex10.2
42laryngitis10.2
43cholangitis, primary sclerosing10.2AIRE, LTF
44systemic lupus erythematosus10.1
45candidiasis, familial, 310.1
46keratitis10.1
47immunodeficiency 31c, autosomal dominant10.1
48alopecia10.1
49hypoparathyroidism10.1
50cryptococcosis10.1

Graphical network of the top 20 diseases related to Candidiasis:



Diseases related to candidiasis

Symptoms for Candidiasis

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Drugs & Therapeutics for Candidiasis

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Drug clinical trials:

Search ClinicalTrials for Candidiasis

Search NIH Clinical Center for Candidiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

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MalaCards organs/tissues related to Candidiasis:

31
Tongue, Brain, Lung, Skin, Heart, T cells, Colon, Testes, Neutrophil, Kidney, Liver, Bone, Monocytes, Bone marrow, Thyroid, Thymus, Myeloid, B cells, Small intestine, Pituitary

Animal Models for Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Candidiasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1IL17F, STAT1, CLEC7A, AIRE
2MP:00053888.7AIRE, CLEC7A, IL17F, IL17RA
3MP:00053767.5AIRE, SH2D1A, CLEC7A, STAT1, IL17RA, CARD9
4MP:00053977.3AIRE, SH2D1A, CLEC7A, STAT1, IL17F, IL17RA
5MP:00053876.5LTF, AIRE, DEFB1, SH2D1A, CLEC7A, STAT1

Publications for Candidiasis

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Articles related to Candidiasis:

(show top 50)    (show all 1644)
idTitleAuthorsYear
1
Pseudomembranous Type of Oral Candidiasis is Associated with Decreased Salivary Flow Rate and Secretory Immunoglobulin A Levels. (25682023)
2015
2
Can intrauterine contraceptive devices lead to VulvoVaginal Candidiasis (VVC) andanemia in Iranian new users? (25637424)
2015
3
Signaling through IL-17C/IL-17RE Is Dispensable for Immunity to Systemic, Oral and Cutaneous Candidiasis. (25849644)
2015
4
Comment on "Vulvovaginal Candidiasis as a Chronic Disease: Diagnostic Criteria and Definition" (24769654)
2014
5
Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis. (25143944)
2014
6
Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis. (25315503)
2014
7
I^-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. Necessity is the mother of invention. (24180439)
2013
8
Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. (24152852)
2013
9
Management of candidaemia and invasive candidiasis in critically ill patients. (23664579)
2013
10
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
11
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
12
Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs. (23738751)
2013
13
Distribution of Candida species among HIV-positive patients with oropharyngeal candidiasis in Accra, Ghana. (23324819)
2013
14
Biochemical analysis and application of molecular display technology on Candida albicans for diagnosing and preventing candidiasis. (24189555)
2013
15
Invasive candidiasis as a cause of sepsis in the critically ill patient. (24157707)
2013
16
Cutaneous candidiasis caused by Candida glabrata in a HIV/AIDS patient. (23970580)
2013
17
Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis. (22052380)
2012
18
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
19
Clinical heterogeneity and diagnostic delay of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. (21295522)
2011
20
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. (21281464)
2011
21
New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome. (21346738)
2011
22
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. (20876174)
2010
23
Oral mucous squamous cell carcinoma-an anticipated consequence of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). (20304522)
2010
24
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. (20123958)
2010
25
Oral candidiasis in HIV+ patients under treatment with protease inhibitors. (19148395)
2008
26
Brain stem candidiasis mimicking cerebellopontine angle tumor. (18313733)
2008
27
An elderly case of type 2 diabetes which developed in association with oral and esophageal candidiasis. (17409603)
2007
28
Methylrosaniline chloride stained vaginal smears for the diagnosis of vulvovaginal candidiasis. (17904142)
2007
29
Oral candidiasis infections with limited clinical findings. (16884077)
2006
30
Molecular evidence of congenital candidiasis associated with maternal candidal vaginitis. (16804443)
2006
31
Oral candidiasis prevention in transplantation patients: a comparative study. (16824148)
2006
32
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis. (16741514)
2006
33
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome with renal failure: impact of posttransplant immunosuppression on disease activity. (16263818)
2006
34
Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients. (16110781)
2005
35
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
36
Management of patients with recurrent vulvovaginal candidiasis. (12749733)
2003
37
Vulvovaginal candidiasis. (12228137)
2002
38
Identification of a novel mutation in the autoimmune regulator (AIRE- 1) gene in a French family with autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy. (11275943)
2001
39
Plasma HIV-1 RNA and route of transmission in oral candidiasis and oral hairy leukoplakia. (10822365)
2000
40
Novel mutations of the autoimmune regulator gene in two siblings with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. (10946904)
2000
41
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. (10084319)
1999
42
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load. (10546876)
1999
43
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
44
Refractory esophageal candidiasis associated with a low molecular weight plasma inhibitor of T-lymphocyte function. (3487248)
1986
45
Vulvovaginal candidiasis: treatment and recurrence. (6963163)
1982
46
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
47
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
48
Clotrimazole: intermittent therapy in chronic mucocutaneous candidiasis. (842517)
1977
49
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
50
Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. (4604245)
1974

Variations for Candidiasis

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Expression for genes affiliated with Candidiasis

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Search GEO for disease gene expression data for Candidiasis.

Pathways for genes affiliated with Candidiasis

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Compounds for genes affiliated with Candidiasis

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Compounds related to Candidiasis according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1flagellin43 2811.0STAT1, DEFB4A
2zymosan439.6LTF, CLEC7A
3pmma439.6HTN3, LTF
4sb 20358043 5910.6STAT1, DEFB4A, AIRE
5hbd2439.5DEFB1, DEFB4A
6deferoxamine43 1210.5LTF, STAT1
7ribavirin43 49 1211.5LTF, STAT1
8endotoxin439.4DEFB4A, STAT1, LTF
9mannose439.3LTF, CLEC7A, DEFB4A
10anti-fungal439.2LTF, HTN3, DEFB4A
11ciprofloxacin43 49 1211.2LTF, DEFB1
12polymyxin b439.2DEFB1, LTF
13fluconazole43 1210.1LTF, HTN3, SH2D1A
14nacl438.9LTF, DEFB1, DEFB4A
15rantes438.8DEFB4A, DEFB1, STAT1, IL17RA
16tyrosine438.5AIRE, DEFB4A, SH2D1A, CLEC7A, STAT1
17cysteine438.3LTF, HTN3, STAT1, DEFB4A
18retinoic acid43 249.2DEFB4A, DEFB1, STAT1, LTF
19dexamethasone43 49 28 1211.1DEFB4A, DEFB1, CLEC7A, STAT1, LTF

GO Terms for genes affiliated with Candidiasis

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Cellular components related to Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.4LTF, IL17RA, IL17F, HTN3, DEFB1, DEFB4A

Biological processes related to Candidiasis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-2 biosynthetic processGO:004507610.1CARD9, IL17F
2regulation of interleukin-6 biosynthetic processGO:004540810.1CARD9, IL17F
3positive regulation of cytokine production involved in inflammatory responseGO:019000179.9IL17F, IL17RA
4response to exogenous dsRNAGO:00433309.8CARD9, STAT1
5negative regulation of angiogenesisGO:00165259.8IL17F, STAT1
6positive regulation of tumor necrosis factor productionGO:00327609.6CLEC7A, CARD9
7humoral immune responseGO:00069599.2LTF, SH2D1A, AIRE
8defense response to bacteriumGO:00427428.8HTN3, DEFB1, DEFB4A
9immune responseGO:00069558.7DEFB1, DEFB4A, AIRE
10innate immune responseGO:00450878.6DEFB4A, DEFB1, CLEC7A, CARD9

Products for genes affiliated with Candidiasis

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Sources for Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet