MCID: CND004
MIFTS: 63

Candidiasis malady

Infectious diseases category

Summaries for Candidiasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by candida species, of which candida albicans is the most common. systemic candida infections are usually confined to severely immunocompromised persons.

MalaCards: Candidiasis, also known as systemic candidiasis, is related to oral candidiasis and chronic mucocutaneous candidiasis. An important gene associated with Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Immune System and Lymphocyte Signaling. The drug flucytosine and the compounds dexamethasone and anti-fungal have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and brain, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Photomicrograph of the fungus Candida albicans

Wikipedia:63 Candidiasis or thrush is a fungal infection (mycosis) of any species from the genus Candida (one genus... more...

Aliases & Classifications for Candidiasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

candidiasis 8 10 44 60
systemic candidiasis 8 42 60
disseminated candidiasis 8 44
systemic candida infections 42


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Disease Ontology8 DOID:1508
ICD9CM27 112.9, 112
MeSH34 D002177
NCIt39 C26711
ICD1025 B37, B37.9

Related Diseases for Candidiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Candidiasis family:

Familial Candidiasis 5 Familial Candidiasis 2
Familial Candidiasis 6 Candidiasis, Familial, 7
Candidiasis, Familial, 8 Candidiasis, Familial, 3

Diseases related to Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1oral candidiasis31.6SKAP2, CD9, LTF, DEFB4A, HTN3
2chronic mucocutaneous candidiasis31.5IL10, AIRE
3bacterial vaginosis30.6MBL2, LTF
4aspergillosis30.5MBL2, CD79A
5leukemia30.5MBL2, STAT1, MPO, SH2D1A, CD9, CD79A
6acute leukemia30.4STAT1, MPO
7diabetes mellitus30.3CD79A, AIRE
8pneumonia30.2MBL2, MPO, DEFB1, DEFB4A, CD9, CD79A
9meningitis30.2CD79A, MBL2
10herpes simplex30.2CD79A, STAT1
11alopecia30.2AIRE
12hepatitis30.1STAT1, AIRE
13hypothyroidism30.1AIRE
14purpura30.1CD79A
15asthma30.0MBL2, STAT1, MPO, DEFB1, DEFB4A, CD79A
16tuberculosis30.0MBL2, STAT1, DEFB4A, CD9, CD79A, IL10
17systemic lupus erythematosus30.0MBL2, STAT1, MPO, LTF, CD79A, IL10
18peritonitis30.0MPO
19dermatitis30.0IL4, CD79A
20lupus erythematosus30.0CD79A
21alopecia areata30.0AIRE
22autoimmune polyendocrine syndrome30.0CARD9
23thyroiditis30.0MBL2, CD79A
24vasculitis29.9MBL2, MPO, SH2D1A, LTF, CD79A
25psoriasis29.9IL4, IL10, LTF, DEFB4A
26autoimmune hemolytic anemia29.9CD79A
27myasthenia gravis29.9IL4, IL10, AIRE
28cystic fibrosis29.7MBL2, MPO, DEFB1, DEFB103B, LTF, DEFB4A
29influenza29.7MBL2, STAT1, LTF, CD9, CD79A
30arthritis29.7STAT1, MPO, LTF, IL10, IL4, IL17RA
31eosinophilia29.7IL4, IL10, CD79A, MPO, STAT1, MBL2
32crohn's disease29.7LTF
33diarrhea29.7CD79A, LTF
34pancreatitis29.7MPO, LTF, IL10
35cryptosporidiosis29.7MBL2, CD79A
36lichen planus29.7DEFB4A
37neutropenia29.7MPO, MBL2
38vitiligo29.7AIRE
39deficiency anemia29.7CD79A
40churg-strauss syndrome29.7MPO, LTF
41toxoplasmosis29.7CD9, CD79A
42myeloma29.7IL4, CD79A, CD9, STAT1
43pemphigus29.7CD79A
44polyneuropathy29.7APCS, CD79A
45uveitis29.7IL4, IL10
46vulvovaginal candidiasis11.0
47vulvovaginitis11.0
48esophageal candidiasis10.8
49esophagitis10.8
50vaginitis10.8

Graphical network of the top 20 diseases related to Candidiasis:



Diseases related to candidiasis

Clinical Features for Candidiasis

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Drugs & Therapeutics for Candidiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Candidiasis

Drug clinical trials:

Search ClinicalTrials for Candidiasis

Search NIH Clinical Center for Candidiasis

Search CenterWatch for Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

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32MalaCards
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MalaCards organs/tissues related to Candidiasis:

32
Lung, Skin, Brain, Heart, T cells, Colon, Testes, Tongue, Liver, Kidney, Bone, Monocytes, Thyroid, Bone marrow, Myeloid, B cells, Thymus, Small intestine, Pituitary

Animal Models for Candidiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7SKAP2, CARD9, MBL2, APCS, STAT1, MPO
2MP:000539710.6AIRE, SH2D1A, MPO, STAT1, APCS, MBL2
3MP:000301210.5IL17RA, AIRE, STAT1
4MP:000537610.4CARD9, MBL2, STAT1, MPO, SH2D1A, AIRE

Publications for Candidiasis

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Sources:
50PubMed
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Articles related to Candidiasis:

(show top 50)    (show all 1555)
idTitleAuthorsYear
1
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India. (23537782)
2013
2
Invasive candidiasis as a cause of sepsis in the critically ill patient. (24157707)
2013
3
Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage. (23092606)
2013
4
Invasive candidiasis and oral manifestations in premature newborns. (23579747)
2013
5
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. (23791509)
2013
6
Candidiasis: An unusual cause of persistent high-grade fever in mid-pregnancy. (24404462)
2013
7
Direct extraction of DNA from positive transparent dressing and swab to identify Candida albicans infection in intertriginous Candidiasis in the inguinal region. (22772509)
2012
8
Comparison between Fluconazole with Oral Protexin Combination and Fluconazole in the Treatment of Vulvovaginal Candidiasis. (23119175)
2012
9
Mucocutaneous candidiasis in a mandrill (Mandrillus sphinx). (22300706)
2012
10
Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis. (22309657)
2012
11
Electromyography and vaginal pressure of the pelvic floor muscles in women with recurrent vulvovaginal candidiasis and vulvodynia. (22523874)
2012
12
An animal experiment about early pulmonary candidiasis in immunosuppressive rabbits: thin-section CT images dynamically observed and proved by histopathological results. (21508200)
2011
13
Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model. (21204918)
2011
14
The epidemiology of Candida species associated with vulvovaginal candidiasis in an Iranian patient population. (21194828)
2011
15
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. (21714643)
2011
16
Challenging issues in neonatal candidiasis. (20513206)
2010
17
Giardiasis diagnosed on esophageal brush smears in a case of chronic alcoholic liver disease with esophageal candidiasis. (18831025)
2008
18
Microbiological and immunological features of oral candidiasis. (17704633)
2007
19
Chronic mucocutaneous candidiasis with agammaglobulinaemia. (17567323)
2007
20
A murine model of esophageal candidiasis with local characteristic symptoms. (17579259)
2007
21
Vulvovaginal candidiasis from non-albicans species: retrospective study of recurrence rate after fluconazole therapy. (16846086)
2006
22
Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review. (16903322)
2006
23
Neonatal candidiasis. (16102651)
2005
24
Chronic mucocutaneous candidiasis; report of three cases with different phenotypes. (17301422)
2005
25
An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis. (15102806)
2004
26
Prevention and treatment of vulvovaginal candidiasis using exogenous Lactobacillus. (12774870)
2003
27
Prevalence of esophageal candidiasis among patients treated with inhaled fluticasone propionate. (14572559)
2003
28
AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype. (12050215)
2002
29
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). (11687165)
2001
30
Risk factors for esophageal candidiasis in a large cohort of HIV-infected patients treated with nucleoside analogues. (11453597)
2001
31
Recurrent vulvovaginal candidiasis. (12112949)
2001
32
Disseminated tuberculosis with ocular tuberculoma and disseminated candidiasis in acquired immunodeficiency syndrome. (11837479)
2001
33
Correlation between in vitro and in vivo antifungal activities in experimental fluconazole-resistant oropharyngeal and esophageal candidiasis. (10835005)
2000
34
The role of Candida dubliniensis in oral candidiasis in human immunodeficiency virus-infected individuals. (10782340)
2000
35
Determinants of incident vulvovaginal candidiasis in human immunodeficiency virus-positive women. (10968602)
2000
36
Fluconazole vs itraconazole-flucytosine association in the treatment of esophageal candidiasis in AIDS patients. A double-blind, multicenter placebo-controlled study. The Candida Esophagitis Multicenter Italian Study (CEMIS) Group. (8989069)
1996
37
Vaginal microbiological flora and sexually transmitted diseases in women with recurrent or current vulvovaginal candidiasis. (7622268)
1995
38
Esophageal candidiasis following omeprazole therapy: a report of two cases. (7797283)
1995
39
Azole-resistant oropharyngeal and esophageal candidiasis in patients with AIDS. (7639986)
1995
40
Oral fluconazole treatment of fungating candidiasis in the keratitis, ichthyosis and deafness (KID) syndrome. (7857850)
1994
41
Esophageal candidiasis in AIDS. Successful therapy with clotrimazole vaginal tablets taken by mouth. (1995261)
1991
42
Myeloperoxidase deficiency as a predisposing factor for deep mucocutaneous candidiasis: a case report. (1846651)
1991
43
Comparison of oral fluconazole and clotrimazole troches as treatment for oral candidiasis in patients infected with human immunodeficiency virus. (2073120)
1990
44
Refractory esophageal candidiasis in acquired immune deficiency syndrome (AIDS). (2327396)
1990
45
Oral candidiasis: forerunner of acquired immunodeficiency syndrome (AIDS)? (3864115)
1985
46
Oral candidiasis and AIDS. (6493294)
1984
47
Necrolytic migratory erythema, presenting as candidiasis, due to a pancreatic glucagonoma. (476569)
1979
48
Antenatal screening for candidiasis, trichomoniasis, and gonorrhoea. (805628)
1975
49
Comparison of clotrimazole cream, Whitfield's ointment and Nystatin ointment for the topical treatment of ringworm infections, pityriasis versicolor, erythrasma and candidiasis. (4582719)
1973
50
The effect of nystatin (mycostatin) on neonatal candidiasis (thrush): a method of eradicating thrush from hospital nurseries. (13608364)
1958

Genetic Variations for Candidiasis

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Expression for genes affiliated with Candidiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Candidiasis

Search GEO for disease gene expression data for Candidiasis.

Pathways for genes affiliated with Candidiasis

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53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Candidiasis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Candidiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.1MBL2, STAT1, DEFB103B, IL4, IL10, CD79A
2anti-fungal4411.0DEFB103B, APCS, HTN3, MBL2, DEFB4A, LTF
3cysteine4411.0MBL2, HTN3, IL4, CD79A, CD9, LTF
4paraffin4411.0MBL2, CD79A, DEFB4A, IL4, IL10, MPO
5rantes4411.0IL17RA, IL4, CD9, DEFB4A, MBL2, STAT1
6neopterin4411.0LTF, CD9, CD79A, IL10, IL4, MBL2
7polymyxin b4411.0MBL2, IL4, DEFB1, LTF, IL10
8ribavirin44 49 1113.0LTF, STAT1, MBL2, IL4, IL10
9histamine44 28 2413.0DEFB4A, MPO, CD79A, IL10, IL4, LTF
10fluconazole44 1112.0SH2D1A, LTF, HTN3, CD79A
11vegf4411.0IL4, IL10, CD79A, LTF, MPO, STAT1
12pentoxifylline44 1112.0MPO, CD9, LTF, IL4
13mannose4411.0CD9, CD79A, DEFB4A, MBL2, LTF
14con a4411.0MBL2, IL4, IL10, CD79A
15methacholine44 1111.9IL4, MPO, LTF, CD79A
16hypothiocyanite44 2411.9LTF, CD79A, MPO
17acidophilus4410.9MPO, IL10, IL4
18thiocyanate44 2411.9MPO, LTF, CD79A
19n acetylcysteine4410.9CD79A, STAT1, MPO, IL4, LTF
20hbd24410.9DEFB103B, DEFB4A, DEFB1
21tuberculin4410.9MBL2, IL10, CD79A
22sb 20358044 5911.9DEFB4A, AIRE, IL10, IL4, STAT1
23cyclophosphamide44 49 1112.9MBL2
24praziquantel44 1111.9CD79A, IL10, IL4
25polyethylene glycol4410.9CD79A, IL4, CD9, MPO
26mdms4410.9IL10, CD9, STAT1
27pmma4410.9CD79A, LTF, HTN3
28azathioprine44 49 2 1113.9IL10, CD79A, IL4, LTF
29retinoic acid44 2411.9CD9, LTF, CD79A, DEFB4A, DEFB1, MPO
30zymosan4410.9MBL2, LTF, MPO
31biotin44 11 2412.9IL4, IL10, CD79A, STAT1
32prednisolone44 28 1112.9IL10, MBL2, MPO, CD79A
33indomethacin44 59 28 1113.9LTF
34monomethyl fumarate4410.8IL4, IL10
35okt34410.8IL4, IL10, CD79A
36saquinavir44 1111.8SKAP2, CD9, APCS
37budesonide44 49 1112.8IL4, MPO, LTF
38lipoteichoic acid4410.8IL10, MBL2, DEFB4A
39thyroxine44 2411.8CD79A, MBL2, IL10, IL4
40polyinosinic-polycytidylic acid4410.8STAT1, IL10, IL4
41endotoxin4410.8STAT1, DEFB4A, LTF
42cyclosporin a44 28 5912.7CD79A, LTF, STAT1
43rolipram44 59 2812.7CD9
44hypoxanthine44 11 2412.7MPO, IL4, LTF
45dmso4410.7MPO, HTN3, IL10, STAT1
46betaseron4410.6IL10, IL4
47dextran sulfate4410.5MPO, CD9, LTF
48naphthol as-d chloroacetate4410.5LTF, MPO
49nacl4410.4MBL2, DEFB1, DEFB4A, LTF
50peptidoglycan44 2811.2MBL2, IL10, DEFB4A

GO Terms for genes affiliated with Candidiasis

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16Gene Ontology
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Cellular components related to Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6HTN3, APCS, DEFB1, DEFB4A, LTF, IL17F
2extracellular spaceGO:00561510.3IL4, IL17F, IL10, MPO, APCS, MBL2

Biological processes related to Candidiasis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274210.8IL10, LTF, DEFB4A, DEFB1, HTN3, MBL2
2negative regulation of growth of symbiont in hostGO:04413010.8MBL2, MPO, IL10
3regulation of interleukin-2 biosynthetic processGO:04507610.7IL17F, CARD9
4regulation of isotype switchingGO:04519110.7IL4, IL10
5regulation of interleukin-6 biosynthetic processGO:04540810.7IL17F, CARD9
6humoral immune responseGO:00695910.7SH2D1A, AIRE, LTF
7type 2 immune responseGO:04209210.6IL4, IL10
8B cell differentiationGO:03018310.6IL4, IL10, CD79A
9positive regulation of cytokine production involved in inflammatory responseGO:190001710.5IL17F, IL17RA
10B cell proliferationGO:04210010.5IL10, CD79A
11positive regulation of MHC class II biosynthetic processGO:04534810.4IL10, IL4
12negative regulation of nitric oxide biosynthetic processGO:04501910.2IL4, IL10

Products for genes affiliated with Candidiasis

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  • Antibodies
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Sources for Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet