MCID: CNN002
MIFTS: 37

Cannabis Abuse malady

Mental diseases category
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Summaries for Cannabis Abuse

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Fully expand this MalaCard
Wikipedia:65 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

MalaCards based summary: Cannabis Abuse, also known as marijuana abuse, is related to schizophrenia and cocaine dependence. An important gene associated with Cannabis Abuse is BDNF (brain-derived neurotrophic factor), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds cerebrolysin and ana 12 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid.

Disease Ontology:8 A substance abuse that involves the recurring use of cannabis despite negative consequences.

Aliases & Classifications for Cannabis Abuse

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Cannabis Abuse, Aliases & Descriptions:

Name: Cannabis Abuse 8 10 44 62
 
Marijuana Abuse 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:9505
MeSH34 D002189
SNOMED-CT57 268769003, 37344009
ICD9CM27 305.2

Related Diseases for Cannabis Abuse

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Graphical network of the top 20 diseases related to Cannabis Abuse:



Diseases related to cannabis abuse

Symptoms for Cannabis Abuse

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Drugs & Therapeutics for Cannabis Abuse

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Drug clinical trials:

Search ClinicalTrials for Cannabis Abuse

Search NIH Clinical Center for Cannabis Abuse

Genetic Tests for Cannabis Abuse

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Anatomical Context for Cannabis Abuse

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MalaCards organs/tissues related to Cannabis Abuse:

32
Testes, Brain, Thyroid

Animal Models for Cannabis Abuse or affiliated genes

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Publications for Cannabis Abuse

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Articles related to Cannabis Abuse:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Parental Cannabis Abuse and Accidental Intoxications in Children: Prevention by Detecting Neglectful Situations and At-Risk Families. (25407034)
2014
2
The association between cannabis abuse and subsequent schizophrenia: a Swedish national co-relative control study. (24990397)
2014
3
Long-term cannabis abuse and early-onset cannabis use increase the severity of cocaine withdrawal during detoxification and rehospitalization rates due to cocaine dependence. (25262527)
2014
4
Cannabis abuse and age at onset in schizophrenia patients with large, rare copy number variants. (24685822)
2014
5
Functioning of Cannabis Abuse and Dependence Criteria Across Two Different Countries: The United States and The Netherlands. (25363693)
2014
6
Cannabinoid hyperemesis should be recognised as an effect of chronic cannabis abuse. (25120899)
2014
7
Cannabis abuse in adolescence and the risk of psychosis: A brief review of the preclinical evidence. (23916409)
2013
8
Monitoring of chronic Cannabis abuse: an LC-MS/MS method for hair analysis. (23305934)
2013
9
Adolescent ischemic stroke associated with anabolic steroid and cannabis abuse. (23382306)
2013
10
Pathways to Psychosis in Cannabis Abuse. (23491968)
2013
11
Cannabis abuse is associated with better emotional memory in schizophrenia: a functional magnetic resonance imaging study. (23906663)
2013
12
A validation of the Cannabis Abuse Screening Test (CAST) using a latent class analysis of the DSM-IV among adolescents. (23519957)
2013
13
Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence. (22907121)
2013
14
Psychometric Properties of the Cannabis Abuse Screening Test in Hungarian Samples of Adolescents and Young Adults. (24217457)
2013
15
Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. (24028906)
2013
16
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
17
Validation of the Cannabis Abuse Screening Test in a sample of cannabis inpatients. (22472963)
2012
18
Cannabis abuse and vulnerability to psychosis: targeting preventive services. (22239586)
2012
19
The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators. (21205060)
2011
20
Psychometric properties of the Cannabis Abuse Screening Test (CAST) in a French sample of adolescents. (20869178)
2011
21
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology. (21534646)
2011
22
Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. (21507586)
2011
23
Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse. (19997844)
2010
24
Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. (20600341)
2010
25
Cannabis abuse and severity of psychotic and affective disorders in Israeli psychiatric inpatients. (19932824)
2010
26
Cannabis abuse and addiction: a contemporary literature review. (19630315)
2009
27
Design paper: The CapOpus trial: a randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis. (18620563)
2008
28
Cyclic vomiting and compulsive bathing with chronic cannabis abuse. (18456571)
2008
29
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. (18176333)
2008
30
The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design. (18482422)
2008
31
Cannabis abuse is associated with decision-making impairment among first-episode patients with schizophrenia-spectrum psychosis. (18005495)
2008
32
Are diagnostic orphans at risk of developing cannabis abuse or dependence? Four-year follow-up of young adult cannabis users not meeting diagnostic criteria. (17716830)
2008
33
The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings. (18753288)
2008
34
Cannabis abuse and risk for psychosis in a prodromal sample. (17383738)
2007
35
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions. (17084563)
2007
36
Cannabis abuse in patients with schizophrenia: pattern and effects on symptomatology. (17374302)
2007
37
Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction. (16806837)
2006
38
Cannabis abuse is not a risk factor for treatment outcome in methadone maintenance treatment: a 1-year prospective study in an Israeli clinic. (14731193)
2004
39
Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. (15500971)
2004
40
Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse. (15479672)
2004
41
Cannabis abuse in Iran. (12760467)
2003
42
Cannabis abuse and oral health care: review and suggestions for management. (14596260)
2003
43
Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. (14870957)
2003
44
Cannabis abuse as a risk factor for depressive symptoms. (11729021)
2001
45
Cannabis abuse and serious suicide attempts. (10615730)
1999
46
Carbamazepine as an adjunct in the treatment of schizophrenia-like psychosis related to cannabis abuse. (10221641)
1999
47
Effects of cannabis abuse on people with serious mental health problems. (8704453)
1996
48
Shared paranoid disorder preceded by cannabis abuse: case report. (3493059)
1987
49
Psychosis after cannabis abuse. (6423193)
1984
50
Cases of cannabis abuse detected by analysis of body fluids. (6971915)
1981

Variations for Cannabis Abuse

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Expression for genes affiliated with Cannabis Abuse

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Expression patterns in normal tissues for genes affiliated with Cannabis Abuse

Search GEO for disease gene expression data for Cannabis Abuse.

Pathways for genes affiliated with Cannabis Abuse

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Pathways related to Cannabis Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.3BDNF, NGF
2
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3NGF, BDNF
3
Show member pathways
MAPK signaling pathway37
9.3NGF, BDNF
49.3NGF, BDNF
5
Show member pathways
9.3BDNF, NGF
6
Show member pathways
9.3NGF, BDNF
79.3NGF, BDNF
8
Show member pathways
9.3BDNF, NGF

Compounds for genes affiliated with Cannabis Abuse

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Compounds related to Cannabis Abuse according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cerebrolysin449.7BDNF, NGF
2ana 12619.7NGF, BDNF
3tlqp 21619.7NGF, BDNF
4bdnf (human)619.7NGF, BDNF
5gnf 5837619.7NGF, BDNF
67,8-dihydroxyflavone61 4410.7NGF, BDNF
7oseltamivir44 1110.7BDNF, NGF
8rasagiline44 1110.7BDNF, NGF
9hcec449.7NGF, BDNF
10selegiline44 1110.7BDNF, NGF
11methadone50 44 1111.7BDNF, NGF
12k252a449.7BDNF, NGF
13desipramine44 50 1111.7NGF, BDNF
146-hydroxydopamine449.7BDNF, NGF
15fluoxetine44 50 28 1112.7BDNF, NGF
16mptp449.6BDNF, NGF
17capsaicin44 2810.6NGF, BDNF
18dbc-amp449.6BDNF, NGF
19anisomycin44 1110.6BDNF, NGF
20levodopa44 1110.6BDNF, NGF
21camptothecin44 61 1111.6NGF, BDNF
22nifedipine44 28 50 1112.6NGF, BDNF
23cocaine44 1110.6BDNF, NGF
24carbachol44 28 1111.5BDNF, NGF
25choline44 24 1111.5NGF, BDNF
26thapsigargin44 6110.5BDNF, NGF
27valine449.4BDNF, NGF
28gnrh449.4BDNF, NGF
29matrigel449.3NGF, BDNF
30nmda44 2810.3BDNF, NGF
31epinephrine44 24 1111.2BDNF, NGF
32indomethacin44 28 61 1112.0BDNF, NGF

GO Terms for genes affiliated with Cannabis Abuse

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Biological processes related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3BDNF, NGF
2positive regulation of neuron differentiationGO:0456669.0BDNF, NGF

Molecular functions related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3BDNF, NGF

Products for genes affiliated with Cannabis Abuse

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cannabis Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet