Summaries for Cannabis Abuse

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Disease Ontology:9 A substance abuse that involves the recurring use of cannabis despite negative consequences.

MalaCards based summary: Cannabis Abuse, also known as marijuana abuse, is related to schizophrenia and cocaine dependence. An important gene associated with Cannabis Abuse is BDNF (brain-derived neurotrophic factor), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds cerebrolysin and ana 12 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid.

Aliases & Classifications for Cannabis Abuse

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Cannabis Abuse, Aliases & Descriptions:

Name: Cannabis Abuse 9 11 43 60
 
Marijuana Abuse 9 43 60


External Ids:

Disease Ontology9 DOID:9505
MeSH33 D002189
SNOMED-CT55 37344009, 268769003
ICD9CM27 305.2

Related Diseases for Cannabis Abuse

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Graphical network of the top 20 diseases related to Cannabis Abuse:



Diseases related to cannabis abuse

Symptoms for Cannabis Abuse

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Drugs & Therapeutics for Cannabis Abuse

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Drug clinical trials:

Search ClinicalTrials for Cannabis Abuse

Search NIH Clinical Center for Cannabis Abuse

Genetic Tests for Cannabis Abuse

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Anatomical Context for Cannabis Abuse

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MalaCards organs/tissues related to Cannabis Abuse:

31
Testes, Brain, Thyroid

Animal Models for Cannabis Abuse or affiliated genes

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Publications for Cannabis Abuse

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Articles related to Cannabis Abuse:

(show top 50)    (show all 87)
idTitleAuthorsYear
1
Methamphetamine and cannabis abuse in adolescence: a quasi-experimental study on specific and long-term neurocognitive effects. (25636791)
2015
2
Cannabis abuse effects on prepulse inhibition in patients with first episode psychosis in schizophrenia. (25716487)
2015
3
Parental Cannabis Abuse and Accidental Intoxications in Children: Prevention by Detecting Neglectful Situations and At-Risk Families. (25407034)
2014
4
The association between cannabis abuse and subsequent schizophrenia: a Swedish national co-relative control study. (24990397)
2014
5
Long-term cannabis abuse and early-onset cannabis use increase the severity of cocaine withdrawal during detoxification and rehospitalization rates due to cocaine dependence. (25262527)
2014
6
Cannabis abuse and age at onset in schizophrenia patients with large, rare copy number variants. (24685822)
2014
7
Functioning of Cannabis Abuse and Dependence Criteria Across Two Different Countries: The United States and The Netherlands. (25363693)
2014
8
Cannabinoid hyperemesis should be recognised as an effect of chronic cannabis abuse. (25120899)
2014
9
Cannabis abuse in adolescence and the risk of psychosis: A brief review of the preclinical evidence. (23916409)
2013
10
Monitoring of chronic Cannabis abuse: an LC-MS/MS method for hair analysis. (23305934)
2013
11
Adolescent ischemic stroke associated with anabolic steroid and cannabis abuse. (23382306)
2013
12
Pathways to Psychosis in Cannabis Abuse. (23491968)
2013
13
Cannabis abuse is associated with better emotional memory in schizophrenia: a functional magnetic resonance imaging study. (23906663)
2013
14
A validation of the Cannabis Abuse Screening Test (CAST) using a latent class analysis of the DSM-IV among adolescents. (23519957)
2013
15
Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence. (22907121)
2013
16
Psychometric Properties of the Cannabis Abuse Screening Test in Hungarian Samples of Adolescents and Young Adults. (24217457)
2013
17
Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. (24028906)
2013
18
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
19
Validation of the Cannabis Abuse Screening Test in a sample of cannabis inpatients. (22472963)
2012
20
Cannabis abuse and vulnerability to psychosis: targeting preventive services. (22239586)
2012
21
The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators. (21205060)
2011
22
Psychometric properties of the Cannabis Abuse Screening Test (CAST) in a French sample of adolescents. (20869178)
2011
23
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology. (21534646)
2011
24
Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. (21507586)
2011
25
Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse. (19997844)
2010
26
Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. (20600341)
2010
27
Cannabis abuse and severity of psychotic and affective disorders in Israeli psychiatric inpatients. (19932824)
2010
28
Cannabis abuse and addiction: a contemporary literature review. (19630315)
2009
29
Design paper: The CapOpus trial: a randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis. (18620563)
2008
30
Cyclic vomiting and compulsive bathing with chronic cannabis abuse. (18456571)
2008
31
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. (18176333)
2008
32
The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design. (18482422)
2008
33
Cannabis abuse is associated with decision-making impairment among first-episode patients with schizophrenia-spectrum psychosis. (18005495)
2008
34
Are diagnostic orphans at risk of developing cannabis abuse or dependence? Four-year follow-up of young adult cannabis users not meeting diagnostic criteria. (17716830)
2008
35
Cannabis abuse and risk for psychosis in a prodromal sample. (17383738)
2007
36
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions. (17084563)
2007
37
Cannabis abuse in patients with schizophrenia: pattern and effects on symptomatology. (17374302)
2007
38
Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction. (16806837)
2006
39
Cannabis abuse is not a risk factor for treatment outcome in methadone maintenance treatment: a 1-year prospective study in an Israeli clinic. (14731193)
2004
40
Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. (15500971)
2004
41
Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse. (15479672)
2004
42
Cannabis abuse in Iran. (12760467)
2003
43
Cannabis abuse and oral health care: review and suggestions for management. (14596260)
2003
44
Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. (14870957)
2003
45
Cannabis abuse as a risk factor for depressive symptoms. (11729021)
2001
46
Cannabis abuse and serious suicide attempts. (10615730)
1999
47
Carbamazepine as an adjunct in the treatment of schizophrenia-like psychosis related to cannabis abuse. (10221641)
1999
48
Shared paranoid disorder preceded by cannabis abuse: case report. (3493059)
1987
49
Psychosis after cannabis abuse. (6423193)
1984
50
Cases of cannabis abuse detected by analysis of body fluids. (6971915)
1981

Variations for Cannabis Abuse

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Expression for genes affiliated with Cannabis Abuse

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Search GEO for disease gene expression data for Cannabis Abuse.

Pathways for genes affiliated with Cannabis Abuse

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Pathways related to Cannabis Abuse according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.3BDNF, NGF
2
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3BDNF, NGF
3
Show member pathways
MAPK signaling pathway36
9.3BDNF, NGF
49.3NGF, BDNF
5
Show member pathways
9.3BDNF, NGF
6
Show member pathways
9.3BDNF, NGF
79.3BDNF, NGF
8
Show member pathways
9.3BDNF, NGF

Compounds for genes affiliated with Cannabis Abuse

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Compounds related to Cannabis Abuse according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cerebrolysin439.7BDNF, NGF
2ana 12599.7NGF, BDNF
3tlqp 21599.7NGF, BDNF
4bdnf (human)599.7NGF, BDNF
5gnf 5837599.7NGF, BDNF
67,8-dihydroxyflavone59 4310.7NGF, BDNF
7oseltamivir43 1210.7BDNF, NGF
8rasagiline43 1210.7BDNF, NGF
9hcec439.7NGF, BDNF
10selegiline43 1210.7BDNF, NGF
11methadone49 43 1211.7BDNF, NGF
12k252a439.7BDNF, NGF
13desipramine43 49 1211.7NGF, BDNF
146-hydroxydopamine439.7BDNF, NGF
15fluoxetine43 49 28 1212.7BDNF, NGF
16mptp439.6BDNF, NGF
17capsaicin43 2810.6NGF, BDNF
18dbc-amp439.6BDNF, NGF
19anisomycin43 1210.6BDNF, NGF
20levodopa43 1210.6BDNF, NGF
21camptothecin43 59 1211.6NGF, BDNF
22nifedipine43 28 49 1212.6NGF, BDNF
23cocaine43 1210.6BDNF, NGF
24carbachol43 28 1211.5BDNF, NGF
25choline43 24 1211.5NGF, BDNF
26thapsigargin43 5910.5BDNF, NGF
27valine439.4BDNF, NGF
28gnrh439.4BDNF, NGF
29matrigel439.3NGF, BDNF
30nmda43 2810.3BDNF, NGF
31epinephrine43 24 1211.2BDNF, NGF
32indomethacin43 28 59 1212.0BDNF, NGF

GO Terms for genes affiliated with Cannabis Abuse

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Biological processes related to Cannabis Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.3BDNF, NGF
2positive regulation of neuron differentiationGO:00456669.0BDNF, NGF

Molecular functions related to Cannabis Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.3BDNF, NGF

Products for genes affiliated with Cannabis Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Cannabis Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet