MCID: CNN002
MIFTS: 35

Cannabis Abuse malady

Summaries for Cannabis Abuse

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

MalaCards: Cannabis Abuse, also known as marijuana abuse, is related to bipolar disorder and cannabis dependence. An important gene associated with Cannabis Abuse is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are p75(NTR)-mediated signaling and Development MAG-dependent inhibition of neurite outgrowth. The compounds tlqp 21 and cerebrolysin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid.

Disease Ontology:8 A substance abuse that involves the recurring use of cannabis despite negative consequences.

Aliases & Classifications for Cannabis Abuse

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

cannabis abuse 8 10 44 60
marijuana abuse 8 44 60


External Ids:

Disease Ontology8 DOID:9505
ICD9CM27 305.2
SNOMED-CT56 37344009, 268769003
MeSH34 D002189

Related Diseases for Cannabis Abuse

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cannabis Abuse:



Diseases related to cannabis abuse

Clinical Features for Cannabis Abuse

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Drugs & Therapeutics for Cannabis Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cannabis Abuse

Drug clinical trials:

Search ClinicalTrials for Cannabis Abuse

Search NIH Clinical Center for Cannabis Abuse

Search CenterWatch for Cannabis Abuse

Genetic Tests for Cannabis Abuse

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Anatomical Context for Cannabis Abuse

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Sources:
32MalaCards
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MalaCards organs/tissues related to Cannabis Abuse:

32
Testes, Brain, Thyroid

Animal Models for Cannabis Abuse or affiliated genes

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Publications for Cannabis Abuse

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Sources:
50PubMed
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Articles related to Cannabis Abuse:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Pathways to Psychosis in Cannabis Abuse. (23491968)
2013
2
Cannabis abuse is associated with better emotional memory in schizophrenia: a functional magnetic resonance imaging study. (23906663)
2013
3
Psychometric Properties of the Cannabis Abuse Screening Test in Hungarian Samples of Adolescents and Young Adults. (24217457)
2013
4
Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. (24028906)
2013
5
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
6
Cannabis abuse and vulnerability to psychosis: targeting preventive services. (22239586)
2012
7
Neurological soft signs in patients with psychosis and cannabis abuse: a systematic review and meta-analysis of paradox. (22716154)
2012
8
The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators. (21205060)
2011
9
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology. (21534646)
2011
10
Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. (21507586)
2011
11
Effects of handedness (left vs right) and cannabis abuse on intermanual coordination and negative symptoms in schizophrenic patients of the paranoid type. (21082479)
2011
12
Bilateral testicular self-castration due to cannabis abuse: a case report. (21861879)
2011
13
Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. (20600341)
2010
14
Cannabis abuse and addiction: a contemporary literature review. (19630315)
2009
15
Pathways to cannabis abuse: a multi-stage model from cannabis availability, cannabis initiation and progression to abuse. (19207351)
2009
16
Design paper: The CapOpus trial: a randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis. (18620563)
2008
17
Cyclic vomiting and compulsive bathing with chronic cannabis abuse. (18456571)
2008
18
The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design. (18482422)
2008
19
Are diagnostic orphans at risk of developing cannabis abuse or dependence? Four-year follow-up of young adult cannabis users not meeting diagnostic criteria. (17716830)
2008
20
The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings. (18753288)
2008
21
The effects of cannabis abuse on the symptoms of schizophrenia: patient perspectives. (18666905)
2008
22
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions. (17084563)
2007
23
Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse. (17522306)
2007
24
Schizophrenia and comorbid self reported cannabis abuse: impact on course, functioning and services use. (17370785)
2007
25
Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction. (16806837)
2006
26
Adequate antipsychotic treatment normalizes serum nerve growth factor concentrations in schizophrenia with and without cannabis or additional substance abuse. (16540246)
2006
27
The stability and impact of environmental factors on substance use and problems after adolescent outpatient treatment for cannabis abuse or dependence. (15783279)
2005
28
Collisions and traffic violations of alcohol, cannabis and cocaine abuse clients before and after treatment. (15203356)
2004
29
Cannabis abuse is not a risk factor for treatment outcome in methadone maintenance treatment: a 1-year prospective study in an Israeli clinic. (14731193)
2004
30
Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. (15500971)
2004
31
Preliminary evidence of an association between childhood abuse and cannabis dependence among African American first-episode schizophrenia-spectrum disorder patients. (15561482)
2004
32
Driving behavior of alcohol, cannabis, and cocaine abuse treatment clients and population controls. (15230084)
2004
33
Cannabis abuse in Iran. (12760467)
2003
34
Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. (14870957)
2003
35
Cannabis abuse and anaesthesia. (14616609)
2003
36
Cannabis abuse and laryngospasm. (12071173)
2002
37
Cannabis abuse as a risk factor for depressive symptoms. (11729021)
2001
38
Cannabis abuse and serious suicide attempts. (10615730)
1999
39
Carbamazepine as an adjunct in the treatment of schizophrenia-like psychosis related to cannabis abuse. (10221641)
1999
40
Quantitative EEG findings associated with chronic stimulant and cannabis abuse and ADHD in an adult male substance use disorder population. (10513323)
1999
41
The relationship between cannabis use and DSM-IV cannabis abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. (10689658)
1998
42
Effects of cannabis abuse on people with serious mental health problems. (8704453)
1996
43
Psychosis and cannabis abuse in The Gambia. A case-control study. (8306122)
1993
44
An epidemiological study of cannabis abuse among college students of Varanasi. (8144224)
1993
45
Influence of cannabis abuse on schizophrenic psychopathology. (1543037)
1992
46
Shared paranoid disorder preceded by cannabis abuse: case report. (3493059)
1987
47
Confirmation of cannabis abuse by the determination of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine with high-performance liquid chromatography and electrochemical detection. (3033002)
1987
48
Psychosis after cannabis abuse. (6424863)
1984
49
Cases of cannabis abuse detected by analysis of body fluids. (6971915)
1981
50
Psychotic symptoms due to cannabis abuse; (a survey of newly admitted mental patients). (5438330)
1970

Genetic Variations for Cannabis Abuse

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Expression for genes affiliated with Cannabis Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cannabis Abuse

Search GEO for disease gene expression data for Cannabis Abuse.

Pathways for genes affiliated with Cannabis Abuse

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Sources:
37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Cannabis Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NGF, BDNF
29.5NGF, BDNF
39.5NGF, BDNF

Compounds for genes affiliated with Cannabis Abuse

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Cannabis Abuse according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1tlqp 21599.8NGF, BDNF
2cerebrolysin449.8BDNF, NGF
3gnf 5837599.8NGF, BDNF
4bdnf (human)599.8NGF, BDNF
5ana 12599.8NGF, BDNF
67,8-dihydroxyflavone44 5910.8BDNF, NGF
7oseltamivir44 1110.8NGF, BDNF
8rasagiline44 1110.8BDNF, NGF
9hcec449.8BDNF, NGF
10selegiline44 1110.8NGF, BDNF
11methadone44 49 1111.7BDNF, NGF
12k252a449.7BDNF, NGF
13desipramine44 49 1111.7BDNF, NGF
14fluoxetine49 44 28 1112.6NGF, BDNF
15mecamylamine28 44 1111.6BDNF, CHRNA3
166-hydroxydopamine449.6NGF, BDNF
17mptp449.6BDNF, NGF
18capsaicin44 2810.5BDNF, NGF
19levodopa44 1110.5NGF, BDNF
20dbc-amp449.4BDNF, NGF
21anisomycin44 1110.2NGF, BDNF
22acetylcholine44 49 28 11 2413.1BDNF, NGF, CHRNA3

GO Terms for genes affiliated with Cannabis Abuse

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Sources:
16Gene Ontology
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Biological processes related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.5NGF, BDNF
2regulation of excitatory postsynaptic membrane potentialGO:0600799.2CHRNA3, BDNF
3positive regulation of neuron differentiationGO:0456669.2NGF, BDNF

Products for genes affiliated with Cannabis Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cannabis Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet