MCID: CNN002
MIFTS: 37

Cannabis Abuse malady

Mental diseases category
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Summaries for Cannabis Abuse

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Fully expand this MalaCard
Wikipedia:65 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

MalaCards: Cannabis Abuse, also known as marijuana abuse, is related to schizophrenia and membranous glomerulonephritis. An important gene associated with Cannabis Abuse is BDNF (brain-derived neurotrophic factor), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds cerebrolysin and ana 12 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid.

Disease Ontology:8 A substance abuse that involves the recurring use of cannabis despite negative consequences.

Aliases & Classifications for Cannabis Abuse

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

cannabis abuse 8 10 45 62
marijuana abuse 8 45 62


External Ids:

Disease Ontology8 DOID:9505
ICD9CM27 305.2
SNOMED-CT58 268769003, 37344009
MeSH35 D002189

Related Diseases for Cannabis Abuse

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cannabis Abuse:



Diseases related to cannabis abuse

Symptoms for Cannabis Abuse

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Drugs & Therapeutics for Cannabis Abuse

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cannabis Abuse

Search NIH Clinical Center for Cannabis Abuse

Genetic Tests for Cannabis Abuse

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Anatomical Context for Cannabis Abuse

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Sources:
33MalaCards
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MalaCards organs/tissues related to Cannabis Abuse:

33
Testes, Brain, Thyroid

Animal Models for Cannabis Abuse or affiliated genes

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Publications for Cannabis Abuse

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Sources:
52PubMed
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Articles related to Cannabis Abuse:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Cannabis abuse in adolescence and the risk of psychosis: A brief review of the preclinical evidence. (23916409)
2013
2
Monitoring of chronic Cannabis abuse: an LC-MS/MS method for hair analysis. (23305934)
2013
3
Pathways to Psychosis in Cannabis Abuse. (23491968)
2013
4
Cannabis abuse is associated with better emotional memory in schizophrenia: a functional magnetic resonance imaging study. (23906663)
2013
5
A validation of the Cannabis Abuse Screening Test (CAST) using a latent class analysis of the DSM-IV among adolescents. (23519957)
2013
6
Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence. (22907121)
2013
7
Psychometric Properties of the Cannabis Abuse Screening Test in Hungarian Samples of Adolescents and Young Adults. (24217457)
2013
8
Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. (24028906)
2013
9
Contributions of ethnicity to differential item functioning of cannabis abuse and dependence symptoms. (23384380)
2013
10
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
11
Validation of the Cannabis Abuse Screening Test in a sample of cannabis inpatients. (22472963)
2012
12
Cannabis abuse and vulnerability to psychosis: targeting preventive services. (22239586)
2012
13
The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators. (21205060)
2011
14
Psychometric properties of the Cannabis Abuse Screening Test (CAST) in a French sample of adolescents. (20869178)
2011
15
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology. (21534646)
2011
16
Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. (21507586)
2011
17
Effects of handedness (left vs right) and cannabis abuse on intermanual coordination and negative symptoms in schizophrenic patients of the paranoid type. (21082479)
2011
18
Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse. (19997844)
2010
19
Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. (20600341)
2010
20
Cannabis abuse and severity of psychotic and affective disorders in Israeli psychiatric inpatients. (19932824)
2010
21
Cannabis abuse and addiction: a contemporary literature review. (19630315)
2009
22
Design paper: The CapOpus trial: a randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis. (18620563)
2008
23
Cyclic vomiting and compulsive bathing with chronic cannabis abuse. (18456571)
2008
24
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. (18176333)
2008
25
The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design. (18482422)
2008
26
Cannabis abuse is associated with decision-making impairment among first-episode patients with schizophrenia-spectrum psychosis. (18005495)
2008
27
Are diagnostic orphans at risk of developing cannabis abuse or dependence? Four-year follow-up of young adult cannabis users not meeting diagnostic criteria. (17716830)
2008
28
The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings. (18753288)
2008
29
The effects of cannabis abuse on the symptoms of schizophrenia: patient perspectives. (18666905)
2008
30
Cannabis abuse and risk for psychosis in a prodromal sample. (17383738)
2007
31
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions. (17084563)
2007
32
Cannabis abuse in patients with schizophrenia: pattern and effects on symptomatology. (17374302)
2007
33
Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction. (16806837)
2006
34
Self-change: A pathway to cannabis abuse resolution. (15967588)
2006
35
Cannabis abuse is not a risk factor for treatment outcome in methadone maintenance treatment: a 1-year prospective study in an Israeli clinic. (14731193)
2004
36
Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. (15500971)
2004
37
Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse. (15479672)
2004
38
A response to 'Cannabis abuse and anaesthesia', Mills P M and Penfold N, Anaesthesia 2003; 58: 1125. (15096263)
2004
39
Cannabis abuse in Iran. (12760467)
2003
40
Cannabis abuse and oral health care: review and suggestions for management. (14596260)
2003
41
Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. (14870957)
2003
42
Psychiatric morbidity of cannabis abuse. (21206852)
2003
43
Cannabis abuse as a risk factor for depressive symptoms. (11729021)
2001
44
Cannabis abuse and serious suicide attempts. (10615730)
1999
45
Carbamazepine as an adjunct in the treatment of schizophrenia-like psychosis related to cannabis abuse. (10221641)
1999
46
Effects of cannabis abuse on people with serious mental health problems. (8704453)
1996
47
A clinical sign for persistent harmful cannabis abuse?: a pilot study. (8756056)
1996
48
Shared paranoid disorder preceded by cannabis abuse: case report. (3493059)
1987
49
Psychosis after cannabis abuse. (6423193)
1984
50
Cases of cannabis abuse detected by analysis of body fluids. (6971915)
1981

Variations for Cannabis Abuse

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Expression for genes affiliated with Cannabis Abuse

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cannabis Abuse

Search GEO for disease gene expression data for Cannabis Abuse.

Pathways for genes affiliated with Cannabis Abuse

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 57SinoBiological, 54R&D Systems, 55Reactome
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Pathways related to Cannabis Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.3BDNF, NGF
2
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3BDNF, NGF
3
Show member pathways
MAPK signaling pathway38
9.3BDNF, NGF
49.3NGF, BDNF
5
Show member pathways
9.3BDNF, NGF
6
Show member pathways
9.3BDNF, NGF
79.3BDNF, NGF
8
Show member pathways
9.3BDNF, NGF

Compounds for genes affiliated with Cannabis Abuse

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Cannabis Abuse according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cerebrolysin459.7BDNF, NGF
2ana 12619.7NGF, BDNF
3tlqp 21619.7NGF, BDNF
4bdnf (human)619.7NGF, BDNF
5gnf 5837619.7NGF, BDNF
67,8-dihydroxyflavone61 4510.7NGF, BDNF
7oseltamivir45 1110.7BDNF, NGF
8rasagiline45 1110.7BDNF, NGF
9hcec459.7NGF, BDNF
10selegiline45 1110.7BDNF, NGF
11methadone51 45 1111.7BDNF, NGF
12k252a459.7BDNF, NGF
13desipramine45 51 1111.7NGF, BDNF
146-hydroxydopamine459.7BDNF, NGF
15fluoxetine45 51 29 1112.7BDNF, NGF
16mptp459.6BDNF, NGF
17capsaicin45 2910.6NGF, BDNF
18dbc-amp459.6BDNF, NGF
19anisomycin45 1110.6BDNF, NGF
20levodopa45 1110.6BDNF, NGF
21camptothecin45 61 1111.6NGF, BDNF
22nifedipine45 29 51 1112.6NGF, BDNF
23cocaine45 1110.6BDNF, NGF
24carbachol45 29 1111.5BDNF, NGF
25choline45 24 1111.5NGF, BDNF
26thapsigargin45 6110.5BDNF, NGF
27valine459.4BDNF, NGF
28gnrh459.4BDNF, NGF
29matrigel459.3NGF, BDNF
30nmda45 2910.3BDNF, NGF
31epinephrine45 24 1111.2BDNF, NGF
32indomethacin45 29 61 1112.0BDNF, NGF

GO Terms for genes affiliated with Cannabis Abuse

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Sources:
16Gene Ontology
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Biological processes related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3BDNF, NGF
2positive regulation of neuron differentiationGO:0456669.0BDNF, NGF

Molecular functions related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3BDNF, NGF

Products for genes affiliated with Cannabis Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cannabis Abuse

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet