MCID: CNN002
MIFTS: 37

Cannabis Abuse malady

Mental diseases category

Summaries for Cannabis Abuse

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

MalaCards: Cannabis Abuse, also known as marijuana abuse, is related to schizophrenia and membranous glomerulonephritis. An important gene associated with Cannabis Abuse is BDNF (brain-derived neurotrophic factor), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds cerebrolysin and ana 12 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid.

Disease Ontology:9 A substance abuse that involves the recurring use of cannabis despite negative consequences.

Aliases & Classifications for Cannabis Abuse

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

cannabis abuse 9 11 46 63
marijuana abuse 9 46 63


External Ids:

Disease Ontology9 DOID:9505
ICD9CM28 305.2
SNOMED-CT59 268769003, 37344009
MeSH36 D002189

Related Diseases for Cannabis Abuse

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Cannabis Abuse:



Diseases related to cannabis abuse

Symptoms for Cannabis Abuse

About this section

Drugs & Therapeutics for Cannabis Abuse

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cannabis Abuse

Drug clinical trials:

Search ClinicalTrials for Cannabis Abuse

Search NIH Clinical Center for Cannabis Abuse

Search CenterWatch for Cannabis Abuse

Genetic Tests for Cannabis Abuse

About this section

Anatomical Context for Cannabis Abuse

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Cannabis Abuse:

34
Testes, Brain, Thyroid

Animal Models for Cannabis Abuse or affiliated genes

About this section

Publications for Cannabis Abuse

About this section
Sources:
53PubMed
See all sources

Articles related to Cannabis Abuse:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Cannabis abuse in adolescence and the risk of psychosis: A brief review of the preclinical evidence. (23916409)
2013
2
Monitoring of chronic Cannabis abuse: an LC-MS/MS method for hair analysis. (23305934)
2013
3
Pathways to Psychosis in Cannabis Abuse. (23491968)
2013
4
Cannabis abuse is associated with better emotional memory in schizophrenia: a functional magnetic resonance imaging study. (23906663)
2013
5
A validation of the Cannabis Abuse Screening Test (CAST) using a latent class analysis of the DSM-IV among adolescents. (23519957)
2013
6
Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence. (22907121)
2013
7
Psychometric Properties of the Cannabis Abuse Screening Test in Hungarian Samples of Adolescents and Young Adults. (24217457)
2013
8
Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. (24028906)
2013
9
Contributions of ethnicity to differential item functioning of cannabis abuse and dependence symptoms. (23384380)
2013
10
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
11
Validation of the Cannabis Abuse Screening Test in a sample of cannabis inpatients. (22472963)
2012
12
Cannabis abuse and vulnerability to psychosis: targeting preventive services. (22239586)
2012
13
The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators. (21205060)
2011
14
Psychometric properties of the Cannabis Abuse Screening Test (CAST) in a French sample of adolescents. (20869178)
2011
15
Developmental pathways to adolescent cannabis abuse and dependence: child maltreatment, emerging personality, and internalizing versus externalizing psychopathology. (21534646)
2011
16
Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. (21507586)
2011
17
Effects of handedness (left vs right) and cannabis abuse on intermanual coordination and negative symptoms in schizophrenic patients of the paranoid type. (21082479)
2011
18
Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse. (19997844)
2010
19
Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. (20600341)
2010
20
Cannabis abuse and severity of psychotic and affective disorders in Israeli psychiatric inpatients. (19932824)
2010
21
Cannabis abuse and addiction: a contemporary literature review. (19630315)
2009
22
Design paper: The CapOpus trial: a randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis. (18620563)
2008
23
Cyclic vomiting and compulsive bathing with chronic cannabis abuse. (18456571)
2008
24
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. (18176333)
2008
25
The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design. (18482422)
2008
26
Cannabis abuse is associated with decision-making impairment among first-episode patients with schizophrenia-spectrum psychosis. (18005495)
2008
27
Are diagnostic orphans at risk of developing cannabis abuse or dependence? Four-year follow-up of young adult cannabis users not meeting diagnostic criteria. (17716830)
2008
28
The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings. (18753288)
2008
29
The effects of cannabis abuse on the symptoms of schizophrenia: patient perspectives. (18666905)
2008
30
Cannabis abuse and risk for psychosis in a prodromal sample. (17383738)
2007
31
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions. (17084563)
2007
32
Cannabis abuse in patients with schizophrenia: pattern and effects on symptomatology. (17374302)
2007
33
Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction. (16806837)
2006
34
Self-change: A pathway to cannabis abuse resolution. (15967588)
2006
35
Cannabis abuse is not a risk factor for treatment outcome in methadone maintenance treatment: a 1-year prospective study in an Israeli clinic. (14731193)
2004
36
Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. (15500971)
2004
37
Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse. (15479672)
2004
38
A response to 'Cannabis abuse and anaesthesia', Mills P M and Penfold N, Anaesthesia 2003; 58: 1125. (15096263)
2004
39
Cannabis abuse in Iran. (12760467)
2003
40
Cannabis abuse and oral health care: review and suggestions for management. (14596260)
2003
41
Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients. (14870957)
2003
42
Psychiatric morbidity of cannabis abuse. (21206852)
2003
43
Cannabis abuse as a risk factor for depressive symptoms. (11729021)
2001
44
Cannabis abuse and serious suicide attempts. (10615730)
1999
45
Carbamazepine as an adjunct in the treatment of schizophrenia-like psychosis related to cannabis abuse. (10221641)
1999
46
Effects of cannabis abuse on people with serious mental health problems. (8704453)
1996
47
A clinical sign for persistent harmful cannabis abuse?: a pilot study. (8756056)
1996
48
Shared paranoid disorder preceded by cannabis abuse: case report. (3493059)
1987
49
Psychosis after cannabis abuse. (6423193)
1984
50
Cases of cannabis abuse detected by analysis of body fluids. (6971915)
1981

Variations for Cannabis Abuse

About this section

Expression for genes affiliated with Cannabis Abuse

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cannabis Abuse

Search GEO for disease gene expression data for Cannabis Abuse.

Pathways for genes affiliated with Cannabis Abuse

About this section
Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 58SinoBiological, 55R&D Systems, 56Reactome
See all sources

Pathways related to Cannabis Abuse according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
9.3BDNF, NGF
2
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.3BDNF, NGF
3
Show member pathways
MAPK signaling pathway39
9.3BDNF, NGF
49.3NGF, BDNF
5
Show member pathways
9.3BDNF, NGF
6
Show member pathways
9.3BDNF, NGF
79.3BDNF, NGF
8
Show member pathways
9.3BDNF, NGF

Compounds for genes affiliated with Cannabis Abuse

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB
See all sources

Compounds related to Cannabis Abuse according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cerebrolysin469.7BDNF, NGF
2ana 12629.7NGF, BDNF
3tlqp 21629.7NGF, BDNF
4bdnf (human)629.7NGF, BDNF
5gnf 5837629.7NGF, BDNF
67,8-dihydroxyflavone62 4610.7NGF, BDNF
7oseltamivir46 1210.7BDNF, NGF
8rasagiline46 1210.7BDNF, NGF
9hcec469.7NGF, BDNF
10selegiline46 1210.7BDNF, NGF
11methadone52 46 1211.7BDNF, NGF
12k252a469.7BDNF, NGF
13desipramine46 52 1211.7NGF, BDNF
146-hydroxydopamine469.7BDNF, NGF
15fluoxetine46 52 30 1212.7BDNF, NGF
16mptp469.6BDNF, NGF
17capsaicin46 3010.6NGF, BDNF
18dbc-amp469.6BDNF, NGF
19anisomycin46 1210.6BDNF, NGF
20levodopa46 1210.6BDNF, NGF
21camptothecin46 62 1211.6NGF, BDNF
22nifedipine46 30 52 1212.6NGF, BDNF
23cocaine46 1210.6BDNF, NGF
24carbachol46 30 1211.5BDNF, NGF
25choline46 25 1211.5NGF, BDNF
26thapsigargin46 6210.5BDNF, NGF
27valine469.4BDNF, NGF
28gnrh469.4BDNF, NGF
29matrigel469.3NGF, BDNF
30nmda46 3010.3BDNF, NGF
31epinephrine46 25 1211.2BDNF, NGF
32indomethacin46 30 62 1212.0BDNF, NGF

GO Terms for genes affiliated with Cannabis Abuse

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3BDNF, NGF
2positive regulation of neuron differentiationGO:0456669.0BDNF, NGF

Molecular functions related to Cannabis Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3BDNF, NGF

Products for genes affiliated with Cannabis Abuse

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cannabis Abuse

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet