MCID: CNN001
MIFTS: 39

Cannabis Dependence malady

Mental diseases category
Download this MalaCard

Summaries for Cannabis Dependence

About this section


Fully expand this MalaCard
Disease Ontology:8 A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.

MalaCards based summary: Cannabis Dependence is related to anxiety disorder and psychotic disorder. An important gene associated with Cannabis Dependence is CNR1 (cannabinoid receptor 1 (brain)), and among its related pathways is Circadian entrainment. The compounds methanandamide and am251 have been mentioned in the context of this disorder. Affiliated tissues include amygdala, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Wikipedia:65 Cannabis dependence or cannabis use disorder is defined in the fifth revision of the Diagnostic and... more...

Aliases & Classifications for Cannabis Dependence

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
See all sources

Cannabis Dependence, Aliases & Descriptions:

Name: Cannabis Dependence 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:1849
NCIt39 C34445
MeSH34 D002189
ICD9CM27 304.3

Related Diseases for Cannabis Dependence

About this section

Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to cannabis dependence

Symptoms for Cannabis Dependence

About this section

Drugs & Therapeutics for Cannabis Dependence

About this section

Drug clinical trials:

Search ClinicalTrials for Cannabis Dependence

Search NIH Clinical Center for Cannabis Dependence

Genetic Tests for Cannabis Dependence

About this section

Anatomical Context for Cannabis Dependence

About this section

MalaCards organs/tissues related to Cannabis Dependence:

32
Amygdala

Animal Models for Cannabis Dependence or affiliated genes

About this section

MGI Mouse Phenotypes related to Cannabis Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ABCB1, HCRT, CHRM5, FAAH, COMT, CNR1
2MP:00053767.8NRG1, PCTP, CNR1, COMT, FAAH, CHRM5
3MP:00036317.6ABCB1, GABRA2, NRG1, UCHL5, CNR1, COMT

Publications for Cannabis Dependence

About this section

Articles related to Cannabis Dependence:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Imaging dopamine transmission parameters in cannabis dependence. (24513022)
2014
2
Different dopaminergic abnormalities underlie cannabis dependence and cannabis-induced psychosis. (24560431)
2014
3
Reliability and validity of the Marijuana Motives Measure among young adult frequent cannabis users and associations with cannabis dependence. (25240105)
2014
4
Baclofen in the management of cannabis dependence syndrome. (24490032)
2014
5
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings. (23140805)
2013
6
Facilitators and barriers in treatment seeking for cannabis dependence. (24035185)
2013
7
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. (22948261)
2013
8
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. (23896215)
2013
9
Predicting the transition from frequent cannabis use to cannabis dependence: a three-year prospective study. (23886472)
2013
10
Cognitive behavioral therapy and the nicotine transdermal patch for dual nicotine and cannabis dependence: a pilot study. (23617864)
2013
11
Taking note of over-the-counter remedies for adolescents with cannabis dependence. (22854924)
2012
12
State of the art treatments for cannabis dependence. (22640758)
2012
13
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. (22745721)
2012
14
Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. (22404223)
2012
15
A genome-wide association study of DSM-IV cannabis dependence. (21668797)
2011
16
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
17
Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. (20627470)
2011
18
Baclofen in cannabis dependence syndrome. (20494335)
2010
19
Cannabis dependence: Effects of cannabis consumption on inter-regional cerebral metabolic relationships in an Indian population. (21180408)
2010
20
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. (19937978)
2010
21
Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. (20189314)
2010
22
Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. (19818563)
2010
23
Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. (19413562)
2009
24
The endocannabinoid system as a target for the treatment of cannabis dependence. (18691603)
2009
25
Antisocial behavioral syndromes in cocaine and cannabis dependence. (18584570)
2008
26
The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence. (19259017)
2008
27
Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence. (17320907)
2008
28
Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. (18270689)
2008
29
Smoking tobacco along with marijuana increases symptoms of cannabis dependence. (18339491)
2008
30
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. (17169504)
2007
31
Factors associated with remission from cannabis dependence in southwest California Indians. (18032229)
2007
32
Assessing cannabis dependence in community surveys: methodological issues. (17623384)
2007
33
Parental alcoholism predicts suicidal behavior in adolescents and young adults with cannabis dependence. (17458326)
2007
34
Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence. (18058411)
2007
35
Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. (17088227)
2006
36
Cannabis dependence and mental health perception amongst people diverted by police after arrest for cannabis-related offending behaviour in Australia. (16575846)
2005
37
Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies. (15899556)
2005
38
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. (15466676)
2004
39
Cannabis dependence and psychotic symptoms in young people. (12537032)
2003
40
Adolescent precursors of cannabis dependence: findings from the Victorian Adolescent Health Cohort Study. (12668409)
2003
41
Tailoring cannabis dependence treatment for a diverse population. (12460135)
2002
42
Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. (11871371)
2002
43
Cannabis dependence in young adults: an Australian population study. (11860390)
2002
44
Early clinical manifestations of cannabis dependence in a community sample. (11543982)
2001
45
One year follow-up of cannabis dependence among long-term users in Sydney, Australia. (10812291)
2000
46
Cannabis dependence and withdrawal. (10615714)
1999
47
Help seeking among a sample entering treatment for cannabis dependence. (10399384)
1999
48
A 12-step treatment approach for marijuana (Cannabis) dependence. (2687482)
1989
49
Personality correlates of cannabis dependence. (525504)
1979
50
The problem of cannabis dependence. (5636685)
1968

Variations for Cannabis Dependence

About this section

Expression for genes affiliated with Cannabis Dependence

About this section
Expression patterns in normal tissues for genes affiliated with Cannabis Dependence

Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for genes affiliated with Cannabis Dependence

About this section

Pathways related to Cannabis Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9GABRA2, CNR1, COMT, FAAH, CHRM5

Compounds for genes affiliated with Cannabis Dependence

About this section

Compounds related to Cannabis Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1methanandamide4410.5CNR1, FAAH
2am25144 2811.5CNR1, FAAH
3marijuana4410.5FAAH, CNR1
4palmitoylethanolamide44 28 6112.5FAAH, CNR1
5oleamide44 28 2412.5CNR1, FAAH
62-arachidonoylglycerol44 2811.5FAAH, CNR1
7mafp4410.5FAAH, CNR1
8delta9-tetrahydrocannabinol4410.5FAAH, CNR1
9ethanolamine44 24 1112.4FAAH, CNR1
10methylphenidate44 50 1112.4COMT, HCRT
11amantadine44 1111.4ABCB1, COMT
12ether44 5011.3FAAH, CNR1
13rimonabant44 28 1112.3CNR1, FAAH, HCRT
14fesoterodine50 1111.3CHRM5, ABCB1
15fluvoxamine44 50 1112.3ABCB1, COMT
16lapatinib44 50 1112.3ABCB1, NRG1
17monoacylglycerol4410.2FAAH, CNR1
18conjugated estrogens50 1111.2ABCB1, COMT
19promethazine44 1111.2CHRM5, ABCB1
20clomipramine44 50 1112.2ABCB1, HCRT
21maprotiline44 50 1112.2ABCB1, CHRM5
22risperidone44 50 28 61 24 1115.2COMT, FAAH, ABCB1
23haloperidol44 50 28 2 1114.2ABCB1, HCRT, FAAH
24venlafaxine44 50 24 1113.2ABCB1, COMT
25scopolamine44 28 24 1113.2CHRM5, ABCB1
26morphine44 50 28 1113.2CNR1, COMT, ABCB1
27cocaine44 1111.2CNR1, COMT, HCRT
285-hydroxytryptamine4410.2HCRT, COMT, CNR1
29desipramine44 50 1112.1ABCB1, CHRM5, CNR1
30quetiapine44 50 28 24 1114.1FAAH, CHRM5, ABCB1
31thiopental44 1111.1GABRA2, FAAH
32pentobarbital44 1111.0HCRT, GABRA2
33paroxetine44 50 28 1113.0COMT, CHRM5, ABCB1
34nitrazepam44 1111.0ABCB1, GABRA2
35selegiline44 1111.0ABCB1, COMT
36nicotine44 28 50 1113.0HCRT, COMT, CNR1
37nmda44 2811.0HCRT, COMT, CNR1, NRG1
38doxepin44 28 50 1113.0CHRM5, ABCB1
39heroin44 50 1111.9COMT, CNR1
40flurazepam44 1110.9ABCB1, GABRA2
41aripiprazole28 44 50 24 1113.9FAAH, CHRM5
42proline449.9FAAH, CBLB, COMT, NRG1
43carbachol44 28 1111.9HCRT, CHRM5, CNR1, NRG1
44acetylcholine44 50 28 24 1113.8NRG1, CNR1, CHRM5, HCRT
45muscimol44 61 2811.8HCRT, GABRA2
46olanzapine44 50 28 24 1113.7CNR1, COMT, FAAH, CHRM5, ABCB1
47clozapine44 28 50 1112.7ABCB1, CHRM5, FAAH, COMT, CNR1
48dopamine44 28 24 1112.6HCRT, CHRM5, COMT, CNR1, NRG1
49nortriptyline50 44 28 1112.5CHRM5, ABCB1
50lipid449.3NRG1, PCTP, CNR1, CBLB, FAAH, HCRT

GO Terms for genes affiliated with Cannabis Dependence

About this section

Products for genes affiliated with Cannabis Dependence

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Cannabis Dependence

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet