MCID: CNN001
MIFTS: 39

Cannabis Dependence malady

Summaries for Cannabis Dependence

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of cannabis despite despite problems related to use of the substance.

MalaCards: Cannabis Dependence is related to alcohol dependence and nicotine dependence. An important gene associated with Cannabis Dependence is CNR1 (cannabinoid receptor 1 (brain)), and among its related pathways are Circadian entrainment and Class A/1 (Rhodopsin-like receptors). The compounds methanandamide and am251 have been mentioned in the context of this disorder. Affiliated tissues include amygdala, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:63 Cannabis dependence or cannabis use disorder is defined in the fifth revision of the Diagnostic and... more...

Aliases & Classifications for Cannabis Dependence

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

cannabis dependence 8 10 44 60


External Ids:

Disease Ontology8 DOID:1849
MeSH34 D002189
NCIt39 C34445
ICD9CM27 304.3

Related Diseases for Cannabis Dependence

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to cannabis dependence

Clinical Features for Cannabis Dependence

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Drugs & Therapeutics for Cannabis Dependence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cannabis Dependence

Drug clinical trials:

Search ClinicalTrials for Cannabis Dependence

Search NIH Clinical Center for Cannabis Dependence

Search CenterWatch for Cannabis Dependence

Genetic Tests for Cannabis Dependence

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Anatomical Context for Cannabis Dependence

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Sources:
32MalaCards
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MalaCards organs/tissues related to Cannabis Dependence:

32
Amygdala

Animal Models for Cannabis Dependence or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cannabis Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.3PENK, COMT, FAAH, GABRA2, CHRM5, CHRNA5
2MP:00036318.2UCHL5, FAAH, GABRA2, CHRM5, CHRNA5, HCRT

Publications for Cannabis Dependence

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Sources:
50PubMed
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Articles related to Cannabis Dependence:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings. (23140805)
2013
2
Facilitators and barriers in treatment seeking for cannabis dependence. (24035185)
2013
3
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. (23896215)
2013
4
Cognitive behavioral therapy and the nicotine transdermal patch for dual nicotine and cannabis dependence: a pilot study. (23617864)
2013
5
Reliability and validity of the Severity of Dependence Scale for detecting cannabis dependence in frequent cannabis users. (23670783)
2013
6
Contributions of ethnicity to differential item functioning of cannabis abuse and dependence symptoms. (23384380)
2013
7
Cannabis dependence, cognitive control and attentional bias for cannabis words. (24018225)
2013
8
A randomized double-blind, placebo-controlled trial of venlafaxine-extended release for co-occurring cannabis dependence and depressive disorders. (23297841)
2013
9
Plasma Cannabinoid Concentrations During Dronabinol Pharmacotherapy for Cannabis Dependence. (24067260)
2013
10
Prevalence and correlates of heavy smoking and nicotine dependence in adolescents with bipolar and cannabis use disorders. (23684537)
2013
11
WITHDRAWN: Psychotherapeutic interventions for cannabis abuse and/or dependence in outpatient settings. (23780682)
2013
12
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. (22745721)
2012
13
Use of aripiprazole in treatment of cannabis dependence in a patient presenting with Borderline Personality Disorder. (22772696)
2012
14
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
15
The Dutch Cannabis Dependence (CanDep) study on the course of frequent cannabis use and dependence: objectives, methods and sample characteristics. (21815231)
2011
16
Probability and predictors of remission from life-time nicotine, alcohol, cannabis or cocaine dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (21077975)
2011
17
Baclofen in cannabis dependence syndrome. (20494335)
2010
18
A comparison of psychosocial and cognitive functioning between depressed and non-depressed patients with cannabis dependence. (20635282)
2010
19
Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. (19413562)
2009
20
Pharmacotherapy for cannabis dependence: how close are we? (19552483)
2009
21
Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. (19002671)
2009
22
Cannabis dependence as a primary drug use-related problem: the case for harm reduction-oriented treatment options. (19938940)
2009
23
Antisocial behavioral syndromes in cocaine and cannabis dependence. (18584570)
2008
24
Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence. (17320907)
2008
25
Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. (18270689)
2008
26
Early cannabis use and DSM-IV nicotine dependence: a twin study. (19032539)
2008
27
Smoking tobacco along with marijuana increases symptoms of cannabis dependence. (18339491)
2008
28
Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. (18855830)
2008
29
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. (17169504)
2007
30
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions. (17084563)
2007
31
Parental alcoholism predicts suicidal behavior in adolescents and young adults with cannabis dependence. (17458326)
2007
32
The reliability and validity of the Severity of Dependence Scale for detecting cannabis dependence in psychosis. (17207121)
2007
33
Concurrent cannabis use during treatment for comorbid ADHD and cocaine dependence: effects on outcome. (17127551)
2006
34
Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. (17088227)
2006
35
Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. (16917946)
2006
36
Recent cannabis abuse decreased stress-induced BOLD signals in the frontal and cingulate cortices of cocaine dependent individuals. (16290108)
2005
37
The stability and impact of environmental factors on substance use and problems after adolescent outpatient treatment for cannabis abuse or dependence. (15783279)
2005
38
The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence. (16269317)
2005
39
Preliminary evidence of an association between childhood abuse and cannabis dependence among African American first-episode schizophrenia-spectrum disorder patients. (15561482)
2004
40
Brief treatments for cannabis dependence: findings from a randomized multisite trial. (15279529)
2004
41
Cannabis dependence in young adults: an Australian population study. (11860390)
2002
42
The structure of cannabis dependence in the community. (12393220)
2002
43
The respiratory effects of cannabis dependence in young adults. (11219370)
2000
44
Cannabis dependence and withdrawal. (10615714)
1999
45
Help seeking among a sample entering treatment for cannabis dependence. (10399384)
1999
46
Cannabis dependence, withdrawal, and reinforcing effects among adolescents with conduct symptoms and substance use disorders. (9589270)
1998
47
Lifetime DSM-IV diagnosis of alcohol, cannabis, cocaine and opiate dependence: six-month reliability in a multi-site clinical sample. (7987188)
1994
48
The diagnosis of marijuana (cannabis) dependence. (2677398)
1989
49
Personality correlates of cannabis dependence. (525504)
1979
50
The problem of cannabis dependence. (5636685)
1968

Genetic Variations for Cannabis Dependence

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Expression for genes affiliated with Cannabis Dependence

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cannabis Dependence

Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for genes affiliated with Cannabis Dependence

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Cannabis Dependence

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Cannabis Dependence according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1methanandamide4410.5CNR1, FAAH
2am25128 4411.5CNR1, FAAH
3marijuana4410.5CNR1, FAAH
4palmitoylethanolamide28 44 5912.5CNR1, FAAH
5oleamide44 28 2412.5CNR1, FAAH
6mafp4410.5FAAH, CNR1
72-arachidonoylglycerol44 2811.4FAAH, CNR1
8Dronabinol1110.4ABCB1, CNR1
9delta9-tetrahydrocannabinol4410.4FAAH, CNR1
10ethanolamine44 11 2412.4FAAH, CNR1
11Fesoterodine1110.4ABCB1, CHRM5
12Meprobamate1110.3GABRA2, ABCB1
13rimonabant44 28 1112.3CNR1, HCRT, FAAH
14heroin44 49 1112.3PENK, CNR1, COMT
15methylphenidate44 49 1112.3HCRT, COMT
16Chlorprothixene1110.3ABCB1, CHRM5
17amantadine44 1111.3COMT, ABCB1
18naloxone44 49 28 1113.3CNR1, ABCB1, PENK
19promethazine44 1111.3ABCB1, CHRM5
20maprotiline44 1111.3CHRM5, ABCB1
21desipramine44 49 1112.2ABCB1, CNR1, CHRM5
22scopolamine44 28 11 2413.2CHRM5, ABCB1
23ether4410.2CNR1, FAAH
24thiopental44 1111.2FAAH, GABRA2
25paroxetine44 49 28 1113.2COMT, CHRM5, ABCB1
26pentobarbital44 1111.2GABRA2, HCRT
27olanzapine49 44 28 11 2414.2COMT, CHRM5, ABCB1
28clozapine44 28 49 1113.1ABCB1, CHRM5, COMT
29morphine44 49 28 1113.1COMT, CNR1, ABCB1, PENK
30nicotine44 49 28 1113.1COMT, CHRNA5, HCRT, CNR1
31cocaine44 1111.1CNR1, HCRT, COMT
32clomipramine44 49 1112.1HCRT, ABCB1
33nmda44 2811.0COMT, HCRT, CNR1, PENK
34naltrexone44 49 28 1113.0PENK, ABCB1
35carbachol44 28 1111.9CHRM5, HCRT, CNR1
365-hydroxytryptamine449.9CNR1, HCRT, COMT
37dopamine44 28 11 2412.8COMT, CHRM5, HCRT, CNR1, PENK
38nitrazepam44 1110.7GABRA2, ABCB1

GO Terms for genes affiliated with Cannabis Dependence

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16Gene Ontology
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Cellular components related to Cannabis Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:0300549.6HCRT, CHRNA5, CHRM5, GABRA2

Biological processes related to Cannabis Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.6HCRT, CHRNA5, GABRA2, COMT
2neuropeptide signaling pathwayGO:0072189.5ELTD1, PENK, HCRT

Products for genes affiliated with Cannabis Dependence

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Sources for Cannabis Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet