MCID: CNN001
MIFTS: 33

Cannabis Dependence malady

Summaries for Cannabis Dependence

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Disease Ontology:9 A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.

MalaCards based summary: Cannabis Dependence is related to alcohol dependence and anxiety disorder. An important gene associated with Cannabis Dependence is CNR1 (cannabinoid receptor 1 (brain)), and among its related pathways is Circadian entrainment. The compounds methanandamide and am251 have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Wikipedia:63 Cannabis dependence or cannabis use disorder is defined in the fifth revision of the Diagnostic and... more...

Aliases & Classifications for Cannabis Dependence

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 27ICD9CM, 38NCIt, 55SNOMED-CT
See all sources

Cannabis Dependence, Aliases & Descriptions:

Name: Cannabis Dependence 9 11 43 60


External Ids:

Disease Ontology9 DOID:1849
MeSH33 D002189
ICD9CM27 304.3
NCIt38 C34445

Related Diseases for Cannabis Dependence

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Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to cannabis dependence

Symptoms for Cannabis Dependence

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Drugs & Therapeutics for Cannabis Dependence

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Drug clinical trials:

Search ClinicalTrials for Cannabis Dependence

Search NIH Clinical Center for Cannabis Dependence

Genetic Tests for Cannabis Dependence

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Anatomical Context for Cannabis Dependence

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MalaCards organs/tissues related to Cannabis Dependence:

31
Brain, Amygdala

Animal Models for Cannabis Dependence or affiliated genes

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MGI Mouse Phenotypes related to Cannabis Dependence:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ABCB1, HCRT, CHRM5, FAAH, COMT, CNR1
2MP:00053767.8HCRT, CHRM5, FAAH, COMT, CNR1, PCTP
3MP:00036317.6GABRA2, ABCB1, HCRT, CHRM5, FAAH, COMT

Publications for Cannabis Dependence

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Articles related to Cannabis Dependence:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
Associations between cigarette smoking and cannabis dependence: a longitudinal study of young cannabis users in the United Kingdom. (25622777)
2015
2
Impact of age at onset of cannabis use on cannabis dependence and driving under the influence in the United States. (25543035)
2015
3
Imaging dopamine transmission parameters in cannabis dependence. (24513022)
2014
4
Different dopaminergic abnormalities underlie cannabis dependence and cannabis-induced psychosis. (24560431)
2014
5
Reliability and validity of the Marijuana Motives Measure among young adult frequent cannabis users and associations with cannabis dependence. (25240105)
2014
6
Baclofen in the management of cannabis dependence syndrome. (24490032)
2014
7
Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: an exploratory study of relationships with abstinence during behavioral treatment. (24793365)
2014
8
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings. (23140805)
2013
9
Facilitators and barriers in treatment seeking for cannabis dependence. (24035185)
2013
10
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. (22948261)
2013
11
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. (23896215)
2013
12
Predicting the transition from frequent cannabis use to cannabis dependence: a three-year prospective study. (23886472)
2013
13
Taking note of over-the-counter remedies for adolescents with cannabis dependence. (22854924)
2012
14
State of the art treatments for cannabis dependence. (22640758)
2012
15
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. (22745721)
2012
16
A genome-wide association study of DSM-IV cannabis dependence. (21668797)
2011
17
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
18
Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. (20627470)
2011
19
Baclofen in cannabis dependence syndrome. (20494335)
2010
20
Cannabis dependence: Effects of cannabis consumption on inter-regional cerebral metabolic relationships in an Indian population. (21180408)
2010
21
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. (19937978)
2010
22
Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. (20189314)
2010
23
Evidence of persistent executive function deficits in cannabis dependence after one month of abstinence. (21308273)
2010
24
Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. (19818563)
2010
25
Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. (19413562)
2009
26
The endocannabinoid system as a target for the treatment of cannabis dependence. (18691603)
2009
27
Antisocial behavioral syndromes in cocaine and cannabis dependence. (18584570)
2008
28
The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence. (19259017)
2008
29
Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence. (17320907)
2008
30
Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. (18270689)
2008
31
Smoking tobacco along with marijuana increases symptoms of cannabis dependence. (18339491)
2008
32
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. (17169504)
2007
33
Factors associated with remission from cannabis dependence in southwest California Indians. (18032229)
2007
34
Assessing cannabis dependence in community surveys: methodological issues. (17623384)
2007
35
Parental alcoholism predicts suicidal behavior in adolescents and young adults with cannabis dependence. (17458326)
2007
36
Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence. (18058411)
2007
37
Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. (17088227)
2006
38
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. (15466676)
2004
39
Cannabis dependence and psychotic symptoms in young people. (12537032)
2003
40
Adolescent precursors of cannabis dependence: findings from the Victorian Adolescent Health Cohort Study. (12668409)
2003
41
Tailoring cannabis dependence treatment for a diverse population. (12460135)
2002
42
Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. (11871371)
2002
43
Cannabis dependence in young adults: an Australian population study. (11860390)
2002
44
Early clinical manifestations of cannabis dependence in a community sample. (11543982)
2001
45
One year follow-up of cannabis dependence among long-term users in Sydney, Australia. (10812291)
2000
46
Cannabis dependence and withdrawal. (10615714)
1999
47
Help seeking among a sample entering treatment for cannabis dependence. (10399384)
1999
48
A 12-step treatment approach for marijuana (Cannabis) dependence. (2687482)
1989
49
Personality correlates of cannabis dependence. (525504)
1979
50
The problem of cannabis dependence. (5636685)
1968

Variations for Cannabis Dependence

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Expression for genes affiliated with Cannabis Dependence

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Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for genes affiliated with Cannabis Dependence

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Pathways related to Cannabis Dependence according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9GABRA2, CNR1, COMT, FAAH, CHRM5

Compounds for genes affiliated with Cannabis Dependence

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Compounds related to Cannabis Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1methanandamide4310.5CNR1, FAAH
2am25143 2811.5CNR1, FAAH
3marijuana4310.5FAAH, CNR1
4palmitoylethanolamide43 28 5912.5FAAH, CNR1
5oleamide43 28 2412.5CNR1, FAAH
62-arachidonoylglycerol43 2811.5FAAH, CNR1
7mafp4310.5FAAH, CNR1
8delta9-tetrahydrocannabinol4310.5FAAH, CNR1
9ethanolamine43 24 1212.4FAAH, CNR1
10methylphenidate43 49 1212.4COMT, HCRT
11amantadine43 1211.4ABCB1, COMT
12ether43 4911.3FAAH, CNR1
13rimonabant43 28 1212.3CNR1, FAAH, HCRT
14fesoterodine49 1211.3CHRM5, ABCB1
15fluvoxamine43 49 1212.3ABCB1, COMT
16lapatinib43 49 1212.3ABCB1, NRG1
17monoacylglycerol4310.2FAAH, CNR1
18conjugated estrogens49 1211.2ABCB1, COMT
19promethazine43 1211.2CHRM5, ABCB1
20clomipramine43 49 1212.2ABCB1, HCRT
21maprotiline43 49 1212.2ABCB1, CHRM5
22risperidone43 49 28 59 24 1215.2COMT, FAAH, ABCB1
23haloperidol43 49 28 2 1214.2ABCB1, HCRT, FAAH
24venlafaxine43 49 24 1213.2ABCB1, COMT
25scopolamine43 28 24 1213.2CHRM5, ABCB1
26morphine43 49 28 1213.2CNR1, COMT, ABCB1
27cocaine43 1211.2CNR1, COMT, HCRT
285-hydroxytryptamine4310.2HCRT, COMT, CNR1
29desipramine43 49 1212.1ABCB1, CHRM5, CNR1
30quetiapine43 49 28 24 1214.1FAAH, CHRM5, ABCB1
31thiopental43 1211.1GABRA2, FAAH
32pentobarbital43 1211.0HCRT, GABRA2
33paroxetine43 49 28 1213.0COMT, CHRM5, ABCB1
34nitrazepam43 1211.0ABCB1, GABRA2
35selegiline43 1211.0ABCB1, COMT
36nicotine43 28 49 1213.0HCRT, COMT, CNR1
37nmda43 2811.0HCRT, COMT, CNR1, NRG1
38doxepin43 28 49 1213.0CHRM5, ABCB1
39heroin43 49 1211.9COMT, CNR1
40flurazepam43 1210.9ABCB1, GABRA2
41aripiprazole28 43 49 24 1213.9FAAH, CHRM5
42proline439.9FAAH, CBLB, COMT, NRG1
43carbachol43 28 1211.9HCRT, CHRM5, CNR1, NRG1
44acetylcholine43 49 28 24 1213.8NRG1, CNR1, CHRM5, HCRT
45muscimol43 59 2811.8HCRT, GABRA2
46olanzapine43 49 28 24 1213.7CNR1, COMT, FAAH, CHRM5, ABCB1
47clozapine43 28 49 1212.7ABCB1, CHRM5, FAAH, COMT, CNR1
48dopamine43 28 24 1212.6HCRT, CHRM5, COMT, CNR1, NRG1
49nortriptyline49 43 28 1212.5CHRM5, ABCB1
50lipid439.3NRG1, PCTP, CNR1, CBLB, FAAH, HCRT

GO Terms for genes affiliated with Cannabis Dependence

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Products for genes affiliated with Cannabis Dependence

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Sources for Cannabis Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet