MCID: CNN001
MIFTS: 38

Cannabis Dependence malady

Categories: Mental diseases

Aliases & Classifications for Cannabis Dependence

Summaries for Cannabis Dependence

Disease Ontology : 12 A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.

MalaCards based summary : Cannabis Dependence, also known as marijuana abuse, is related to schizophrenia and personality disorder. An important gene associated with Cannabis Dependence is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are GABAergic synapse and Neuroscience. The drugs Ethanol and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Cannabis Dependence

Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to Cannabis Dependence

Symptoms & Phenotypes for Cannabis Dependence

MGI Mouse Phenotypes related to Cannabis Dependence:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 ABCB1 CNR1 COMT FAAH HCRT MGLL
2 homeostasis/metabolism MP:0005376 9.17 ABCB1 CNR1 COMT FAAH HCRT MGLL

Drugs & Therapeutics for Cannabis Dependence

Drugs for Cannabis Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
2
Dopamine Approved Phase 4,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Buspirone Approved, Investigational Phase 4,Phase 2 36505-84-7 2477
5
Nicotine Approved Phase 4,Phase 2,Phase 1,Early Phase 1 54-11-5 942 89594
6
Clozapine Approved Phase 4 5786-21-0 2818
7
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
8
Bupropion Approved Phase 4,Phase 2 34841-39-9, 34911-55-2 444
9
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
10
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
11 Antipsychotic Agents Phase 4,Phase 2
12 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
13 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
14 Quetiapine Fumarate Phase 4,Phase 2 111974-72-2
15 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Early Phase 1
16 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
17
Serotonin Phase 4,Phase 2 50-67-9 5202
18 Serotonin Agents Phase 4,Phase 2
19 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Central Nervous System Stimulants Phase 4,Phase 2,Phase 1
21 Cholinergic Agents Phase 4,Phase 2,Phase 1
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
23 Serotonin Antagonists Phase 4
24 Antidepressive Agents Phase 4,Phase 3,Phase 2
25 Antidepressive Agents, Second-Generation Phase 4,Phase 2
26 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Phase 1
27 Serotonin Uptake Inhibitors Phase 4,Phase 2
28 Dopamine Agents Phase 4,Phase 2,Phase 1,Early Phase 1
29 Dopamine Antagonists Phase 4
30 Anti-Anxiety Agents Phase 4,Phase 2,Phase 3,Early Phase 1
31 Nicotinic Agonists Phase 4,Phase 2,Phase 1
32 GABA Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 2
34 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
35 Dopamine Uptake Inhibitors Phase 4,Phase 2,Phase 1
36 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Atomoxetine Hydrochloride Phase 4,Phase 2
38 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
40 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
41 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
43 Progestins Phase 4
44
Acetylcysteine Approved, Investigational Phase 3,Phase 2,Phase 1 616-91-1 12035
45
Naltrexone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 16590-41-3 5360515
46
Clonidine Approved Phase 2, Phase 3 4205-90-7 2803
47
Dronabinol Approved, Illicit Phase 2, Phase 3, Phase 1, Early Phase 1 1972-08-3 16078 2978
48
Lofexidine Approved, Investigational Phase 2, Phase 3 31036-80-3 30668
49
Nabilone Approved, Investigational Phase 2, Phase 3 51022-71-0 5284592
50
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878

Interventional clinical trials:

(show top 50) (show all 138)
id Name Status NCT ID Phase
1 Improving Substance Use and Clinical Outcomes in Heavy Cannabis Users With Quetiapine Unknown status NCT01153490 Phase 4
2 Buspirone Treatment for Marijuana Dependence Completed NCT00875836 Phase 4
3 Nicotine Patch for Marijuana Withdrawal Completed NCT01400243 Phase 4
4 Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual Completed NCT00498550 Phase 4
5 Substance Dependent Teens - Impact of Treating Depression Study 1 - 1 Completed NCT00061113 Phase 4
6 Bupropion for ADHD in Adolescents With Substance Use Disorder Completed NCT00936299 Phase 4
7 Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) With Atomoxetine in Young Adults and Its Effects on Functional Outcomes Completed NCT00510276 Phase 4
8 Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics Completed NCT00290121 Phase 4
9 Progesterone and Brain Imaging Study Recruiting NCT01954966 Phase 4
10 Clozapine for Cannabis Use in Schizophrenia Active, not recruiting NCT01639872 Phase 4
11 A Comparison of Adolescent Group Therapy and Transitional Family Therapy for Adolescent Alcohol and Drug Abusers Unknown status NCT00484367 Phase 2, Phase 3
12 CANDIS-II: Evaluation of the Cognitive-behavioral Treatment Programme CANDIS Unknown status NCT00673647 Phase 3
13 Combined Pharmacotherapy for Cannabis Dependency Completed NCT01020019 Phase 2, Phase 3
14 Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment Completed NCT01675661 Phase 3
15 Nabilone & Marijuana Addiction Completed NCT01025700 Phase 2, Phase 3
16 Teen Marijuana Check-Up Completed NCT01109563 Phase 3
17 "Effectiveness of a Brief Intervention for Substances Consumption Linked to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): A Randomized Control Trial in Chilean Primary Care." Completed NCT01573416 Phase 3
18 Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling Completed NCT00221975 Phase 3
19 Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder Completed NCT00194129 Phase 3
20 Dronabinol Naltrexone Treatment for Opioid Dependence Completed NCT01024335 Phase 2, Phase 3
21 Nabilone for Cannabis Dependence: A Pilot Study Recruiting NCT01347762 Phase 2, Phase 3
22 Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia Recruiting NCT01598896 Phase 2, Phase 3
23 Facilitating the Behavioral Treatment of Cannabis Use Disorder Not yet recruiting NCT02946489 Phase 2, Phase 3
24 A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana Unknown status NCT01005810 Phase 2
25 Efficacy and Safety of the Hcoil Deep TMS for the Treatment of Cannabis Addiction Unknown status NCT00543036 Phase 1, Phase 2
26 Clinical Trial of N-acetylcysteine Versus Placebo Efficacy in the Cannabis Withdrawal Unknown status NCT01439828 Phase 2
27 CANDIS - Targeted Treatment for Cannabis Disorders Unknown status NCT00252980 Phase 2
28 Web-based vs In-person Personalized Feedback Intervention for Comorbid Substance Use and Disordered Gambling Unknown status NCT01529047 Phase 2
29 Project RAP: Reaching Adolescents for Prevention Unknown status NCT00183157 Phase 2
30 Study of Quetiapine Treatment for Cannabis Dependence Completed NCT00954681 Phase 2
31 Sativex and Behavioral-relapse Prevention Strategy in Cannabis Dependence Completed NCT01747850 Phase 2
32 Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence Completed NCT01292642 Phase 2
33 Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence Completed NCT02088177 Phase 1, Phase 2
34 Atomoxetine for the Treatment of Cannabis Dependence Completed NCT00167297 Phase 2
35 Gabapentin Treatment of Cannabis Dependence Completed NCT00974376 Phase 2
36 Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults Completed NCT00656487 Phase 2
37 Gabapentin Treatment of Cannabis Dependence Completed NCT00395044 Phase 2
38 Vilazodone Treatment for Marijuana Dependence Completed NCT01574183 Phase 2
39 Baclofen Effects on Marijuana Dependence Completed NCT02011516 Phase 2
40 Dronabinol Treatment for Marijuana Addiction Completed NCT00217971 Phase 2
41 Free Venlafaxine Treatment for Marijuana Addiction and Depression - 1 Completed NCT00131456 Phase 2
42 Effectiveness of Buspirone and Motivational Enhancement Therapy for the Treatment of Marijuana Dependence - 1 Completed NCT00149617 Phase 2
43 Atomoxetine Treatment for ADHD and Marijuana Dependence Completed NCT00360269 Phase 2
44 Treatment for Cannabis Withdrawal and Dependence Completed NCT01611948 Phase 2
45 Effectiveness of Selegiline in Treating Marijuana Dependent Individuals - 1 Completed NCT00218517 Phase 2
46 Pregnenolone and Marijuana Dependence Completed NCT02439814 Phase 2
47 A Placebo-Controlled Trial of Buspirone for Treatment of Marijuana Dependence Completed NCT00360191 Phase 2
48 Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence Completed NCT00149643 Phase 2
49 An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents Completed NCT00542750 Phase 1, Phase 2
50 Effect of Baclofen on Marijuana Withdrawal and Relapse Completed NCT00373295 Phase 2

Search NIH Clinical Center for Cannabis Dependence

Cochrane evidence based reviews: marijuana abuse

Genetic Tests for Cannabis Dependence

Anatomical Context for Cannabis Dependence

MalaCards organs/tissues related to Cannabis Dependence:

39
Amygdala, Brain

Publications for Cannabis Dependence

Articles related to Cannabis Dependence:

(show top 50) (show all 132)
id Title Authors Year
1
Treatment seeking in cannabis dependence: The role of social cognition. ( 27894043 )
2017
2
Social cognitive predictors of treatment outcome in cannabis dependence. ( 27883947 )
2017
3
Deficits in striatal dopamine release in cannabis dependence. ( 27001613 )
2016
4
Genome-wide Significant Associations for Cannabis Dependence Severity: Relevance to Psychiatric Disorders. ( 27027914 )
2016
5
Persistent cannabis dependence and alcohol dependence represent risks for midlife economic and social problems: A longitudinal cohort study. ( 28008372 )
2016
6
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. ( 27028160 )
2016
7
Vilazodone for cannabis dependence: A randomized, controlled pilot trial. ( 26685701 )
2016
8
Differential effects of cannabis dependence on cortical inhibition in patients with schizophrenia and non-psychiatric controls. ( 27964871 )
2016
9
Anxiety Sensitivity and Distress Intolerance as Predictors of Cannabis Dependence Symptoms, Problems, and Craving: The Mediating Role of Coping Motives. ( 27797690 )
2016
10
Sativex Associated With Behavioral-Relapse Prevention Strategy as Treatment for Cannabis Dependence: A Case Series. ( 27261670 )
2016
11
Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. ( 26213314 )
2015
12
Risk-taking in schizophrenia and controls with and without cannabis dependence. ( 25467541 )
2015
13
Impact of age at onset of cannabis use on cannabis dependence and driving under the influence in the United States. ( 25543035 )
2015
14
Concordance of Direct and Indirect Measures of Medication Adherence in A Treatment Trial for Cannabis Dependence. ( 26028133 )
2015
15
Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. ( 26595473 )
2015
16
Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial. ( 26386827 )
2015
17
Three-Year Course of Cannabis Dependence and Prediction of Persistence. ( 26044258 )
2015
18
Maintenance Check-ups Following Treatment for Cannabis Dependence. ( 25922136 )
2015
19
Psychosocial Determinants of Cannabis Dependence: A Systematic Review of the Literature. ( 26551358 )
2015
20
Associations between cigarette smoking and cannabis dependence: a longitudinal study of young cannabis users in the United Kingdom. ( 25622777 )
2015
21
Open-label pilot study of quetiapine treatment for cannabis dependence. ( 24963729 )
2014
22
The Moderating Role of Experiential Avoidance in the Relationship between Posttraumatic Stress Disorder Symptom Severity and Cannabis Dependence. ( 25478317 )
2014
23
Reliability and validity of the Marijuana Motives Measure among young adult frequent cannabis users and associations with cannabis dependence. ( 25240105 )
2014
24
Imaging dopamine transmission parameters in cannabis dependence. ( 24513022 )
2014
25
Cross-sectional and prospective relation of cannabis potency, dosing and smoking behaviour with cannabis dependence: an ecological study. ( 24628797 )
2014
26
Pharmacotherapies for cannabis dependence. ( 25515775 )
2014
27
Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: an exploratory study of relationships with abstinence during behavioral treatment. ( 24793365 )
2014
28
Different dopaminergic abnormalities underlie cannabis dependence and cannabis-induced psychosis. ( 24560431 )
2014
29
Potential use of Magnolia officinalis bark polyphenols in the treatment of cannabis dependence. ( 25459131 )
2014
30
Baclofen in the management of cannabis dependence syndrome. ( 24490032 )
2014
31
Treatment of cannabis dependence using escitalopram in combination with cognitive-behavior therapy: a double-blind placebo-controlled study. ( 24359507 )
2014
32
Predicting the transition from frequent cannabis use to cannabis dependence: a three-year prospective study. ( 23886472 )
2013
33
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. ( 22948261 )
2013
34
Reliability and validity of the Severity of Dependence Scale for detecting cannabis dependence in frequent cannabis users. ( 23670783 )
2013
35
A randomized double-blind, placebo-controlled trial of venlafaxine-extended release for co-occurring cannabis dependence and depressive disorders. ( 23297841 )
2013
36
Cognitive behavioral therapy and the nicotine transdermal patch for dual nicotine and cannabis dependence: a pilot study. ( 23617864 )
2013
37
A multi-center, randomized controlled trial of a group psychological intervention for psychosis with comorbid cannabis dependence over the early course of illness. ( 23187069 )
2013
38
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. ( 23896215 )
2013
39
Plasma Cannabinoid Concentrations During Dronabinol Pharmacotherapy for Cannabis Dependence. ( 24067260 )
2013
40
Posttraumatic stress disorder and cannabis use characteristics among military veterans with cannabis dependence. ( 23617872 )
2013
41
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings. ( 23140805 )
2013
42
Facilitators and barriers in treatment seeking for cannabis dependence. ( 24035185 )
2013
43
Cannabis dependence, cognitive control and attentional bias for cannabis words. ( 24018225 )
2013
44
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. ( 22745721 )
2012
45
Orexin A expression and promoter methylation in patients with cannabis dependence in comparison to nicotine-dependent cigarette smokers and nonsmokers. ( 22846875 )
2012
46
Delusional-like experiences are more common in those with cannabis dependence disorder, very early-onset alcohol use or dependence disorders, and daily smokers. ( 22466088 )
2012
47
Taking note of over-the-counter remedies for adolescents with cannabis dependence. ( 22854924 )
2012
48
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. ( 22520967 )
2012
49
State of the art treatments for cannabis dependence. ( 22640758 )
2012
50
Use of aripiprazole in treatment of cannabis dependence in a patient presenting with Borderline Personality Disorder. ( 22772696 )
2012

Variations for Cannabis Dependence

Expression for Cannabis Dependence

Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for Cannabis Dependence

GO Terms for Cannabis Dependence

Cellular components related to Cannabis Dependence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 COMT NRG1
2 dendrite GO:0030425 9.13 COMT NRG1 PENK
3 axon GO:0030424 8.92 CNR1 COMT NRG1 PENK

Biological processes related to Cannabis Dependence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 9.43 NRG1 PENK
2 sensory perception of pain GO:0019233 9.4 CNR1 PENK
3 response to nicotine GO:0035094 9.37 CNR1 PENK
4 response to lipopolysaccharide GO:0032496 9.33 CNR1 COMT PENK
5 response to morphine GO:0043278 9.32 CNR1 PENK
6 regulation of sensory perception of pain GO:0051930 9.26 COMT MGLL
7 arachidonic acid metabolic process GO:0019369 8.96 FAAH MGLL
8 startle response GO:0001964 8.62 NRG1 PENK

Molecular functions related to Cannabis Dependence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 HCRT PENK
2 acylglycerol lipase activity GO:0047372 8.62 FAAH MGLL

Sources for Cannabis Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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