MCID: CNN001
MIFTS: 38

Cannabis Dependence malady

Mental diseases category

Summaries for Cannabis Dependence

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A drug dependence that involves the continued use of cannabis despite despite problems related to use of the substance.

MalaCards: Cannabis Dependence is related to schizophrenia and anxiety disorder. An important gene associated with Cannabis Dependence is CNR1 (cannabinoid receptor 1 (brain)), and among its related pathways is Circadian entrainment. The compounds methanandamide and am251 have been mentioned in the context of this disorder. Affiliated tissues include amygdala, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Wikipedia:66 Cannabis dependence is defined in the fifth revision of the Diagnostic and Statistical Manual of Mental... more...

Aliases & Classifications for Cannabis Dependence

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

cannabis dependence 9 11 46 63


External Ids:

Disease Ontology9 DOID:1849
NCIt41 C34445
ICD9CM28 304.3
MeSH36 D002189

Related Diseases for Cannabis Dependence

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to cannabis dependence

Symptoms for Cannabis Dependence

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Drugs & Therapeutics for Cannabis Dependence

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cannabis Dependence

Drug clinical trials:

Search ClinicalTrials for Cannabis Dependence

Search NIH Clinical Center for Cannabis Dependence

Search CenterWatch for Cannabis Dependence

Genetic Tests for Cannabis Dependence

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Anatomical Context for Cannabis Dependence

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Sources:
34MalaCards
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MalaCards organs/tissues related to Cannabis Dependence:

34
Amygdala

Animal Models for Cannabis Dependence or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Cannabis Dependence:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ABCB1, HCRT, CHRM5, FAAH, COMT, CNR1
2MP:00053767.8HCRT, CHRM5, FAAH, COMT, CNR1, PCTP
3MP:00036317.6GABRA2, ABCB1, HCRT, CHRM5, FAAH, COMT

Publications for Cannabis Dependence

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Sources:
53PubMed
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Articles related to Cannabis Dependence:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings. (23140805)
2013
2
Facilitators and barriers in treatment seeking for cannabis dependence. (24035185)
2013
3
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. (22948261)
2013
4
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. (23896215)
2013
5
Predicting the transition from frequent cannabis use to cannabis dependence: a three-year prospective study. (23886472)
2013
6
Cognitive behavioral therapy and the nicotine transdermal patch for dual nicotine and cannabis dependence: a pilot study. (23617864)
2013
7
Reliability and validity of the Severity of Dependence Scale for detecting cannabis dependence in frequent cannabis users. (23670783)
2013
8
Taking note of over-the-counter remedies for adolescents with cannabis dependence. (22854924)
2012
9
State of the art treatments for cannabis dependence. (22640758)
2012
10
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. (22745721)
2012
11
Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. (22404223)
2012
12
A genome-wide association study of DSM-IV cannabis dependence. (21668797)
2011
13
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
14
Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. (20627470)
2011
15
The Dutch Cannabis Dependence (CanDep) study on the course of frequent cannabis use and dependence: objectives, methods and sample characteristics. (21815231)
2011
16
Baclofen in cannabis dependence syndrome. (20494335)
2010
17
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. (19937978)
2010
18
Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. (20189314)
2010
19
Evidence of persistent executive function deficits in cannabis dependence after one month of abstinence. (21308273)
2010
20
Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. (19818563)
2010
21
Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. (19413562)
2009
22
The endocannabinoid system as a target for the treatment of cannabis dependence. (18691603)
2009
23
Pharmacotherapy for cannabis dependence: how close are we? (19552483)
2009
24
Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. (19002671)
2009
25
Antisocial behavioral syndromes in cocaine and cannabis dependence. (18584570)
2008
26
The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence. (19259017)
2008
27
Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence. (17320907)
2008
28
Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. (18270689)
2008
29
Smoking tobacco along with marijuana increases symptoms of cannabis dependence. (18339491)
2008
30
Use of dronabinol for cannabis dependence: two case reports and review. (18393061)
2008
31
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. (17169504)
2007
32
Factors associated with remission from cannabis dependence in southwest California Indians. (18032229)
2007
33
Assessing cannabis dependence in community surveys: methodological issues. (17623384)
2007
34
Parental alcoholism predicts suicidal behavior in adolescents and young adults with cannabis dependence. (17458326)
2007
35
Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence. (18058411)
2007
36
Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. (17088227)
2006
37
Pothead or pot smoker? A taxometric investigation of cannabis dependence. (16901347)
2006
38
Cannabis dependence and mental health perception amongst people diverted by police after arrest for cannabis-related offending behaviour in Australia. (16575846)
2005
39
Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies. (15899556)
2005
40
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. (15466676)
2004
41
Cannabis dependence and psychotic symptoms in young people. (12537032)
2003
42
Adolescent precursors of cannabis dependence: findings from the Victorian Adolescent Health Cohort Study. (12668409)
2003
43
Tailoring cannabis dependence treatment for a diverse population. (12460135)
2002
44
Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. (11871371)
2002
45
Early clinical manifestations of cannabis dependence in a community sample. (11543982)
2001
46
One year follow-up of cannabis dependence among long-term users in Sydney, Australia. (10812291)
2000
47
Help seeking among a sample entering treatment for cannabis dependence. (10399384)
1999
48
A 12-step treatment approach for marijuana (Cannabis) dependence. (2687482)
1989
49
Personality correlates of cannabis dependence. (525504)
1979
50
The problem of cannabis dependence. (5636685)
1968

Variations for Cannabis Dependence

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Expression for genes affiliated with Cannabis Dependence

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cannabis Dependence

Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for genes affiliated with Cannabis Dependence

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Sources:
51PathCards, 31KEGG
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Pathways related to Cannabis Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9GABRA2, CNR1, COMT, FAAH, CHRM5

Compounds for genes affiliated with Cannabis Dependence

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 12DrugBank, 52PharmGKB, 3BitterDB
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Compounds related to Cannabis Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1methanandamide4610.5CNR1, FAAH
2am25146 3011.5CNR1, FAAH
3marijuana4610.5FAAH, CNR1
4palmitoylethanolamide46 30 6212.5FAAH, CNR1
5oleamide46 30 2512.5CNR1, FAAH
62-arachidonoylglycerol46 3011.5FAAH, CNR1
7mafp4610.5FAAH, CNR1
8delta9-tetrahydrocannabinol4610.5FAAH, CNR1
9ethanolamine46 25 1212.4FAAH, CNR1
10methylphenidate46 52 1212.4COMT, HCRT
11amantadine46 1211.4ABCB1, COMT
12ether46 5211.3FAAH, CNR1
13rimonabant46 30 1212.3CNR1, FAAH, HCRT
14fesoterodine52 1211.3CHRM5, ABCB1
15fluvoxamine46 52 1212.3ABCB1, COMT
16lapatinib46 52 1212.3ABCB1, NRG1
17monoacylglycerol4610.2FAAH, CNR1
18conjugated estrogens52 1211.2ABCB1, COMT
19promethazine46 1211.2CHRM5, ABCB1
20clomipramine46 52 1212.2ABCB1, HCRT
21maprotiline46 52 1212.2ABCB1, CHRM5
22risperidone46 52 30 62 25 1215.2COMT, FAAH, ABCB1
23haloperidol46 52 30 3 1214.2ABCB1, HCRT, FAAH
24venlafaxine46 52 25 1213.2ABCB1, COMT
25scopolamine46 30 25 1213.2CHRM5, ABCB1
26morphine46 52 30 1213.2CNR1, COMT, ABCB1
27cocaine46 1211.2CNR1, COMT, HCRT
285-hydroxytryptamine4610.2HCRT, COMT, CNR1
29desipramine46 52 1212.1ABCB1, CHRM5, CNR1
30quetiapine46 52 30 25 1214.1FAAH, CHRM5, ABCB1
31thiopental46 1211.1GABRA2, FAAH
32pentobarbital46 1211.0HCRT, GABRA2
33paroxetine46 52 30 1213.0COMT, CHRM5, ABCB1
34nitrazepam46 1211.0ABCB1, GABRA2
35selegiline46 1211.0ABCB1, COMT
36nicotine46 30 52 1213.0HCRT, COMT, CNR1
37nmda46 3011.0HCRT, COMT, CNR1, NRG1
38doxepin46 30 52 1213.0CHRM5, ABCB1
39heroin46 52 1211.9COMT, CNR1
40flurazepam46 1210.9ABCB1, GABRA2
41aripiprazole30 46 52 25 1213.9FAAH, CHRM5
42proline469.9FAAH, CBLB, COMT, NRG1
43carbachol46 30 1211.9HCRT, CHRM5, CNR1, NRG1
44acetylcholine46 52 30 25 1213.8NRG1, CNR1, CHRM5, HCRT
45muscimol46 62 3011.8HCRT, GABRA2
46olanzapine46 52 30 25 1213.7CNR1, COMT, FAAH, CHRM5, ABCB1
47clozapine46 30 52 1212.7ABCB1, CHRM5, FAAH, COMT, CNR1
48dopamine46 30 25 1212.6HCRT, CHRM5, COMT, CNR1, NRG1
49nortriptyline52 46 30 1212.5CHRM5, ABCB1
50lipid469.3NRG1, PCTP, CNR1, CBLB, FAAH, HCRT

GO Terms for genes affiliated with Cannabis Dependence

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Products for genes affiliated with Cannabis Dependence

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  • Antibodies
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  • Lysates
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Sources for Cannabis Dependence

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet