MCID: CNN001
MIFTS: 38

Cannabis Dependence malady

Mental diseases category
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Summaries for Cannabis Dependence

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of cannabis despite despite problems related to use of the substance.

MalaCards: Cannabis Dependence is related to schizophrenia and anxiety disorder. An important gene associated with Cannabis Dependence is CNR1 (cannabinoid receptor 1 (brain)), and among its related pathways is Circadian entrainment. The compounds methanandamide and am251 have been mentioned in the context of this disorder. Affiliated tissues include amygdala, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Wikipedia:65 Cannabis dependence is defined in the fifth revision of the Diagnostic and Statistical Manual of Mental... more...

Aliases & Classifications for Cannabis Dependence

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

cannabis dependence 8 10 45 62


External Ids:

Disease Ontology8 DOID:1849
NCIt40 C34445
ICD9CM27 304.3
MeSH35 D002189

Related Diseases for Cannabis Dependence

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to cannabis dependence

Symptoms for Cannabis Dependence

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Drugs & Therapeutics for Cannabis Dependence

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cannabis Dependence

Search NIH Clinical Center for Cannabis Dependence

Genetic Tests for Cannabis Dependence

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Anatomical Context for Cannabis Dependence

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Sources:
33MalaCards
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MalaCards organs/tissues related to Cannabis Dependence:

33
Amygdala

Animal Models for Cannabis Dependence or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cannabis Dependence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ABCB1, HCRT, CHRM5, FAAH, COMT, CNR1
2MP:00053767.8HCRT, CHRM5, FAAH, COMT, CNR1, PCTP
3MP:00036317.6GABRA2, ABCB1, HCRT, CHRM5, FAAH, COMT

Publications for Cannabis Dependence

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Sources:
52PubMed
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Articles related to Cannabis Dependence:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings. (23140805)
2013
2
Facilitators and barriers in treatment seeking for cannabis dependence. (24035185)
2013
3
CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. (22948261)
2013
4
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. (23896215)
2013
5
Predicting the transition from frequent cannabis use to cannabis dependence: a three-year prospective study. (23886472)
2013
6
Cognitive behavioral therapy and the nicotine transdermal patch for dual nicotine and cannabis dependence: a pilot study. (23617864)
2013
7
Reliability and validity of the Severity of Dependence Scale for detecting cannabis dependence in frequent cannabis users. (23670783)
2013
8
Taking note of over-the-counter remedies for adolescents with cannabis dependence. (22854924)
2012
9
State of the art treatments for cannabis dependence. (22640758)
2012
10
Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. (22745721)
2012
11
Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. (22404223)
2012
12
A genome-wide association study of DSM-IV cannabis dependence. (21668797)
2011
13
Depression and psychological distress in tobacco smokers and people with cannabis dependence in the National Survey of Mental Health and Wellbeing. (21806512)
2011
14
Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. (20627470)
2011
15
The Dutch Cannabis Dependence (CanDep) study on the course of frequent cannabis use and dependence: objectives, methods and sample characteristics. (21815231)
2011
16
Baclofen in cannabis dependence syndrome. (20494335)
2010
17
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. (19937978)
2010
18
Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. (20189314)
2010
19
Evidence of persistent executive function deficits in cannabis dependence after one month of abstinence. (21308273)
2010
20
Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. (19818563)
2010
21
Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. (19413562)
2009
22
The endocannabinoid system as a target for the treatment of cannabis dependence. (18691603)
2009
23
Pharmacotherapy for cannabis dependence: how close are we? (19552483)
2009
24
Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. (19002671)
2009
25
Antisocial behavioral syndromes in cocaine and cannabis dependence. (18584570)
2008
26
The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence. (19259017)
2008
27
Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence. (17320907)
2008
28
Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. (18270689)
2008
29
Smoking tobacco along with marijuana increases symptoms of cannabis dependence. (18339491)
2008
30
Use of dronabinol for cannabis dependence: two case reports and review. (18393061)
2008
31
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. (17169504)
2007
32
Factors associated with remission from cannabis dependence in southwest California Indians. (18032229)
2007
33
Assessing cannabis dependence in community surveys: methodological issues. (17623384)
2007
34
Parental alcoholism predicts suicidal behavior in adolescents and young adults with cannabis dependence. (17458326)
2007
35
Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence. (18058411)
2007
36
Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. (17088227)
2006
37
Pothead or pot smoker? A taxometric investigation of cannabis dependence. (16901347)
2006
38
Cannabis dependence and mental health perception amongst people diverted by police after arrest for cannabis-related offending behaviour in Australia. (16575846)
2005
39
Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies. (15899556)
2005
40
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. (15466676)
2004
41
Cannabis dependence and psychotic symptoms in young people. (12537032)
2003
42
Adolescent precursors of cannabis dependence: findings from the Victorian Adolescent Health Cohort Study. (12668409)
2003
43
Tailoring cannabis dependence treatment for a diverse population. (12460135)
2002
44
Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. (11871371)
2002
45
Early clinical manifestations of cannabis dependence in a community sample. (11543982)
2001
46
One year follow-up of cannabis dependence among long-term users in Sydney, Australia. (10812291)
2000
47
Help seeking among a sample entering treatment for cannabis dependence. (10399384)
1999
48
A 12-step treatment approach for marijuana (Cannabis) dependence. (2687482)
1989
49
Personality correlates of cannabis dependence. (525504)
1979
50
The problem of cannabis dependence. (5636685)
1968

Variations for Cannabis Dependence

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Expression for genes affiliated with Cannabis Dependence

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cannabis Dependence

Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for genes affiliated with Cannabis Dependence

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Sources:
50PathCards, 30KEGG
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Pathways related to Cannabis Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9GABRA2, CNR1, COMT, FAAH, CHRM5

Compounds for genes affiliated with Cannabis Dependence

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Cannabis Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1methanandamide4510.5CNR1, FAAH
2am25145 2911.5CNR1, FAAH
3marijuana4510.5FAAH, CNR1
4palmitoylethanolamide45 29 6112.5FAAH, CNR1
5oleamide45 29 2412.5CNR1, FAAH
62-arachidonoylglycerol45 2911.5FAAH, CNR1
7mafp4510.5FAAH, CNR1
8delta9-tetrahydrocannabinol4510.5FAAH, CNR1
9ethanolamine45 24 1112.4FAAH, CNR1
10methylphenidate45 51 1112.4COMT, HCRT
11amantadine45 1111.4ABCB1, COMT
12ether45 5111.3FAAH, CNR1
13rimonabant45 29 1112.3CNR1, FAAH, HCRT
14fesoterodine51 1111.3CHRM5, ABCB1
15fluvoxamine45 51 1112.3ABCB1, COMT
16lapatinib45 51 1112.3ABCB1, NRG1
17monoacylglycerol4510.2FAAH, CNR1
18conjugated estrogens51 1111.2ABCB1, COMT
19promethazine45 1111.2CHRM5, ABCB1
20clomipramine45 51 1112.2ABCB1, HCRT
21maprotiline45 51 1112.2ABCB1, CHRM5
22risperidone45 51 29 61 24 1115.2COMT, FAAH, ABCB1
23haloperidol45 51 29 3 1114.2ABCB1, HCRT, FAAH
24venlafaxine45 51 24 1113.2ABCB1, COMT
25scopolamine45 29 24 1113.2CHRM5, ABCB1
26morphine45 51 29 1113.2CNR1, COMT, ABCB1
27cocaine45 1111.2CNR1, COMT, HCRT
285-hydroxytryptamine4510.2HCRT, COMT, CNR1
29desipramine45 51 1112.1ABCB1, CHRM5, CNR1
30quetiapine45 51 29 24 1114.1FAAH, CHRM5, ABCB1
31thiopental45 1111.1GABRA2, FAAH
32pentobarbital45 1111.0HCRT, GABRA2
33paroxetine45 51 29 1113.0COMT, CHRM5, ABCB1
34nitrazepam45 1111.0ABCB1, GABRA2
35selegiline45 1111.0ABCB1, COMT
36nicotine45 29 51 1113.0HCRT, COMT, CNR1
37nmda45 2911.0HCRT, COMT, CNR1, NRG1
38doxepin45 29 51 1113.0CHRM5, ABCB1
39heroin45 51 1111.9COMT, CNR1
40flurazepam45 1110.9ABCB1, GABRA2
41aripiprazole29 45 51 24 1113.9FAAH, CHRM5
42proline459.9FAAH, CBLB, COMT, NRG1
43carbachol45 29 1111.9HCRT, CHRM5, CNR1, NRG1
44acetylcholine45 51 29 24 1113.8NRG1, CNR1, CHRM5, HCRT
45muscimol45 61 2911.8HCRT, GABRA2
46olanzapine45 51 29 24 1113.7CNR1, COMT, FAAH, CHRM5, ABCB1
47clozapine45 29 51 1112.7ABCB1, CHRM5, FAAH, COMT, CNR1
48dopamine45 29 24 1112.6HCRT, CHRM5, COMT, CNR1, NRG1
49nortriptyline51 45 29 1112.5CHRM5, ABCB1
50lipid459.3NRG1, PCTP, CNR1, CBLB, FAAH, HCRT

GO Terms for genes affiliated with Cannabis Dependence

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Products for genes affiliated with Cannabis Dependence

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  • Antibodies
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Sources for Cannabis Dependence

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet