MCID: CNN001
MIFTS: 39

Cannabis Dependence malady

Summaries for Cannabis Dependence

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A drug dependence that involves the continued use of cannabis despite despite problems related to use of the substance.

MalaCards: Cannabis Dependence is related to alcohol dependence and nicotine dependence. An important gene associated with Cannabis Dependence is CNR1 (cannabinoid receptor 1 (brain)), and among its related pathways are Circadian entrainment and Class A/1 (Rhodopsin-like receptors). The compounds methanandamide and am251 have been mentioned in the context of this disorder. Affiliated tissues include amygdala, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:63 Cannabis dependence or cannabis use disorder is defined in the fifth revision of the Diagnostic and... more...

Aliases & Classifications for Cannabis Dependence

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

cannabis dependence 8 10 44 60


External Ids:

Disease Ontology8 DOID:1849
MeSH34 D002189
NCIt39 C34445
ICD9CM27 304.3

Related Diseases for Cannabis Dependence

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cannabis Dependence:



Diseases related to cannabis dependence

Clinical Features for Cannabis Dependence

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Drugs & Therapeutics for Cannabis Dependence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cannabis Dependence

Drug clinical trials:

Search ClinicalTrials for Cannabis Dependence

Search NIH Clinical Center for Cannabis Dependence

Search CenterWatch for Cannabis Dependence

Genetic Tests for Cannabis Dependence

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Anatomical Context for Cannabis Dependence

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Sources:
32MalaCards
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MalaCards organs/tissues related to Cannabis Dependence:

32
Amygdala

Animal Models for Cannabis Dependence or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cannabis Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.3PENK, COMT, FAAH, GABRA2, CHRM5, CHRNA5
2MP:00036318.2UCHL5, FAAH, GABRA2, CHRM5, CHRNA5, HCRT

Publications for Cannabis Dependence

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Sources:
50PubMed
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Articles related to Cannabis Dependence:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Predicting the transition from frequent cannabis use to cannabis dependence: a three-year prospective study. (23886472)
2013
2
Posttraumatic stress disorder and cannabis use characteristics among military veterans with cannabis dependence. (23617872)
2013
3
A multi-center, randomized controlled trial of a group psychological intervention for psychosis with comorbid cannabis dependence over the early course of illness. (23187069)
2013
4
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
5
Taking note of over-the-counter remedies for adolescents with cannabis dependence. (22854924)
2012
6
State of the art treatments for cannabis dependence. (22640758)
2012
7
Two Sides of the Same Coin: Cannabis Dependence and Mental Health Problems in Help-Seeking Adolescent and Young Adult Outpatients. (23243411)
2012
8
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. (22520967)
2012
9
The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators. (21205060)
2011
10
A genome-wide association study of DSM-IV cannabis dependence. (21668797)
2011
11
Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins. (21507586)
2011
12
Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. (20627470)
2011
13
Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial. (21310551)
2011
14
Cannabis use patterns and their association with DSM-IV cannabis dependence and gender. (22042220)
2011
15
Are the effects of cannabis dependence on glucose metabolism similar to schizophrenia? An FDG PET understanding. (21431002)
2011
16
Cannabis dependence: Effects of cannabis consumption on inter-regional cerebral metabolic relationships in an Indian population. (21180408)
2010
17
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. (19937978)
2010
18
Evidence of persistent executive function deficits in cannabis dependence after one month of abstinence. (21308273)
2010
19
Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability. (19818563)
2010
20
Generalizability of clinical trials for cannabis dependence to community samples. (20537813)
2010
21
From child maltreatment to adolescent cannabis abuse and dependence: a developmental cascade model. (20883588)
2010
22
Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. (19016476)
2009
23
The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. (19443135)
2009
24
A preliminary trial: double-blind comparison of nefazodone, bupropion-SR, and placebo in the treatment of cannabis dependence. (19219666)
2009
25
Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. (19625010)
2009
26
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. (18176333)
2008
27
The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design. (18482422)
2008
28
Are diagnostic orphans at risk of developing cannabis abuse or dependence? Four-year follow-up of young adult cannabis users not meeting diagnostic criteria. (17716830)
2008
29
Use of dronabinol for cannabis dependence: two case reports and review. (18393061)
2008
30
Prospective assessment of cannabis withdrawal in adolescents with cannabis dependence: a pilot study. (18176332)
2008
31
Factors associated with remission from cannabis dependence in southwest California Indians. (18032229)
2007
32
Assessing cannabis dependence in community surveys: methodological issues. (17623384)
2007
33
Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence. (18058411)
2007
34
Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence. (17984400)
2007
35
The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians. (17290447)
2007
36
Pothead or pot smoker? A taxometric investigation of cannabis dependence. (16901347)
2006
37
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. (15466676)
2004
38
Predictors of treatment contact among individuals with cannabis dependence. (15083557)
2004
39
Cannabis dependence and psychotic symptoms in young people. (12537032)
2003
40
Adolescent precursors of cannabis dependence: findings from the Victorian Adolescent Health Cohort Study. (12668409)
2003
41
Tailoring cannabis dependence treatment for a diverse population. (12460135)
2002
42
Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. (11871371)
2002
43
Early clinical manifestations of cannabis dependence in a community sample. (11543982)
2001
44
Patterns and correlates of cannabis dependence among long-term users in an Australian rural area. (9813896)
1998
45
The relationship between cannabis use and DSM-IV cannabis abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. (10689658)
1998
46
The prevalence of marijuana (cannabis) use and dependence in cocaine dependence. (2234615)
1990
47
The diagnosis of alcohol and cannabis dependence (addiction) in cocaine dependence (addiction). (2272719)
1990
48
The diagnosis of alcohol and cannabis dependence in cocaine dependence. (2343796)
1990
49
Cannabis dependence and tolerance production. (2165734)
1990
50
Aversion therapy of cannabis dependence in Nigeria. (6606553)
1983

Genetic Variations for Cannabis Dependence

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Expression for genes affiliated with Cannabis Dependence

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cannabis Dependence

Search GEO for disease gene expression data for Cannabis Dependence.

Pathways for genes affiliated with Cannabis Dependence

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Cannabis Dependence

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Cannabis Dependence according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1methanandamide4410.5CNR1, FAAH
2am25128 4411.5CNR1, FAAH
3marijuana4410.5CNR1, FAAH
4palmitoylethanolamide28 44 5912.5CNR1, FAAH
5oleamide44 28 2412.5CNR1, FAAH
6mafp4410.5FAAH, CNR1
72-arachidonoylglycerol44 2811.4FAAH, CNR1
8Dronabinol1110.4ABCB1, CNR1
9delta9-tetrahydrocannabinol4410.4FAAH, CNR1
10ethanolamine44 11 2412.4FAAH, CNR1
11Fesoterodine1110.4ABCB1, CHRM5
12Meprobamate1110.3GABRA2, ABCB1
13rimonabant44 28 1112.3CNR1, HCRT, FAAH
14heroin44 49 1112.3PENK, CNR1, COMT
15methylphenidate44 49 1112.3HCRT, COMT
16Chlorprothixene1110.3ABCB1, CHRM5
17amantadine44 1111.3COMT, ABCB1
18naloxone44 49 28 1113.3CNR1, ABCB1, PENK
19promethazine44 1111.3ABCB1, CHRM5
20maprotiline44 1111.3CHRM5, ABCB1
21desipramine44 49 1112.2ABCB1, CNR1, CHRM5
22scopolamine44 28 11 2413.2CHRM5, ABCB1
23ether4410.2CNR1, FAAH
24thiopental44 1111.2FAAH, GABRA2
25paroxetine44 49 28 1113.2COMT, CHRM5, ABCB1
26pentobarbital44 1111.2GABRA2, HCRT
27olanzapine49 44 28 11 2414.2COMT, CHRM5, ABCB1
28clozapine44 28 49 1113.1ABCB1, CHRM5, COMT
29morphine44 49 28 1113.1COMT, CNR1, ABCB1, PENK
30nicotine44 49 28 1113.1COMT, CHRNA5, HCRT, CNR1
31cocaine44 1111.1CNR1, HCRT, COMT
32clomipramine44 49 1112.1HCRT, ABCB1
33nmda44 2811.0COMT, HCRT, CNR1, PENK
34naltrexone44 49 28 1113.0PENK, ABCB1
35carbachol44 28 1111.9CHRM5, HCRT, CNR1
365-hydroxytryptamine449.9CNR1, HCRT, COMT
37dopamine44 28 11 2412.8COMT, CHRM5, HCRT, CNR1, PENK
38nitrazepam44 1110.7GABRA2, ABCB1

GO Terms for genes affiliated with Cannabis Dependence

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16Gene Ontology
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Cellular components related to Cannabis Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:0300549.6HCRT, CHRNA5, CHRM5, GABRA2

Biological processes related to Cannabis Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.6HCRT, CHRNA5, GABRA2, COMT
2neuropeptide signaling pathwayGO:0072189.5ELTD1, PENK, HCRT

Products for genes affiliated with Cannabis Dependence

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Sources for Cannabis Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet