MCID: CPP003
MIFTS: 35

Cap Polyposis malady

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Cap Polyposis

Aliases & Descriptions for Cap Polyposis:

Name: Cap Polyposis 56
Inflammatory Myoglandular Polyps 56
Eroded Polypoid Hyperplasia 56
Cap Inflammatory Polyposis 56
Polypoid Prolapsing Folds 56

Characteristics:

Orphanet epidemiological data:

56
cap polyposis
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adolescent,Adult,Childhood,Elderly;

Classifications:



External Ids:

Orphanet 56 ORPHA160148
ICD10 via Orphanet 34 D12.6

Summaries for Cap Polyposis

MalaCards based summary : Cap Polyposis, also known as inflammatory myoglandular polyps, is related to choroid epithelioid cell melanoma and trophoblastic neoplasm, and has symptoms including colorectal polyposis, constipation and abdominal pain. An important gene associated with Cap Polyposis is ALB (Albumin), and among its related pathways/superpathways are HIV Life Cycle and CLEC7A (Dectin-1) signaling. The drugs Cola and Omega 3 Fatty Acid have been mentioned in the context of this disorder. Affiliated tissues include colon.

Related Diseases for Cap Polyposis

Diseases related to Cap Polyposis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 choroid epithelioid cell melanoma 10.1 MUC2 MUC5AC
2 trophoblastic neoplasm 10.1 MUC2 MUC5AC
3 strabismus 10.1 MUC2 MUC5AC
4 papillary adenofibroma 10.1 MUC2 MUC5AC
5 sagittal sinus thrombosis 10.1 MUC2 MUC5AC
6 myopathy, lactic acidosis, and sideroblastic anemia 2 10.1 MUC2 MUC5AC
7 lateral sinus thrombosis 10.1 MUC2 MUC5AC
8 retina lymphoma 10.1 MUC2 MUC5AC
9 pseudo-meigs syndrome 10.1 MUC2 MUC5AC
10 vaginal villous adenoma 10.1 MUC2 MUC5AC
11 prostate stromal sarcoma 10.1 MUC2 MUC5AC
12 lung clear cell carcinoma 10.1 MUC2 MUC5AC
13 solitary rectal ulcer syndrome 10.1
14 spastic diplegia infantile type 10.1 MUC2 MUC5AC
15 fallopian tube leiomyosarcoma 10.1 ALB MUC2
16 acute stress disorder 10.1 MUC2 MUC5AC
17 his bundle tachycardia 10.0 MUC2 MUC5AC
18 basophilic carcinoma 10.0 MUC2 MUC5AC
19 protein-losing enteropathy 10.0
20 colitis 10.0
21 spinal muscular atrophy with progressive myoclonic epilepsy 10.0 MUC2 MUC5AC
22 thymus mucoepidermoid carcinoma 10.0 MUC4 MUC5AC
23 acute chest syndrome 10.0 ALB MUC5AC
24 sarcomatoid mesothelioma 10.0 MUC2 MUC4
25 aicardi-goutieres syndrome 10.0 MUC2 MUC4
26 lymphedema 10.0 MUC4 MUC5AC
27 bladder colonic type adenocarcinoma 10.0 MUC2 MUC5AC
28 proctitis 9.9 ALB MUC2
29 ulcerative colitis 9.9
30 porencephaly, cerebellar hypoplasia, and internal malformations 9.9 ALB MUC2 MUC5AC
31 nephropathy with pretibial epidermolysis bullosa and deafness 9.9 ALB MUC2 MUC5AC
32 long bones of lower limb cancer 9.9 MUC4 MUC5AC
33 pituitary carcinoma 9.9 MUC2 MUC4
34 pearson syndrome 9.9 MUC4 MUC5AC
35 laryngeal mucoepidermoid carcinoma 9.8 MUC2 MUC4 MUC5AC
36 fibular collateral ligament bursitis 9.8 MUC2 MUC4 MUC5AC
37 refractory plasma cell neoplasm 9.8 MUC2 MUC4 MUC5AC
38 odontotrichoungual-digital-palmar syndrome 9.8 MUC2 MUC4 MUC5AC
39 retrograde amnesia 9.8 MUC2 MUC4 MUC5AC
40 gastroesophageal junction adenocarcinoma 9.8 MUC2 MUC4 MUC5AC
41 mucositis 9.7
42 rectal prolapse 9.7
43 crohn's disease 9.7
44 inflammatory bowel disease 9.7
45 membranoproliferative glomerulonephritis 9.7 ALB MUC2 MUC3A MUC5AC
46 brachydactyly, type b1 9.6 MUC2 MUC3A MUC4 MUC5AC
47 hyperlysinemia 9.5 MUC2 MUC3A MUC4 MUC5AC
48 basal cell carcinoma 7 9.5 MUC2 MUC4 MUC5AC
49 maternally-inherited cardiomyopathy and hearing loss 9.4 ALB MUC2 MUC3A MUC4 MUC5AC

Graphical network of the top 20 diseases related to Cap Polyposis:



Diseases related to Cap Polyposis

Symptoms & Phenotypes for Cap Polyposis

Human phenotypes related to Cap Polyposis:

56 32 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 colorectal polyposis 56 32 Obligate (100%) HP:0200063
2 constipation 56 32 Very frequent (99-80%) HP:0002019
3 abdominal pain 56 32 Very frequent (99-80%) HP:0002027
4 hematochezia 56 32 Very frequent (99-80%) HP:0002573
5 chronic atrophic gastritis 56 32 Very frequent (99-80%) HP:0002582
6 weight loss 56 32 Frequent (79-30%) HP:0001824
7 abdominal distention 56 32 Frequent (79-30%) HP:0003270
8 diarrhea 56 Frequent (79-30%)

Drugs & Therapeutics for Cap Polyposis

Drugs for Cap Polyposis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 2, Phase 3
2 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
3
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
4
Sulindac Approved Phase 2 38194-50-2 5352 1548887
5
Pramipexole Approved, Investigational Phase 2 104632-26-0 59868 119570
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
7
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
8 Analgesics Phase 2,Phase 1
9 Dopamine agonists Phase 2
10 Neurotransmitter Agents Phase 2
11 Cyclooxygenase Inhibitors Phase 2,Phase 1
12 Analgesics, Non-Narcotic Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 2,Phase 1
14 Dopamine Agents Phase 2
15 Protective Agents Phase 2
16 Protein Kinase Inhibitors Phase 2
17 Anti-Inflammatory Agents Phase 2,Phase 1
18 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1
19 Retinol palmitate Phase 2
20 Antirheumatic Agents Phase 2,Phase 1
21 Antioxidants Phase 2
22 Antiparkinson Agents Phase 2
23
Curcumin Phase 2 458-37-7 969516
24 Turmeric extract Phase 2
25 retinol Nutraceutical Phase 2
26 Turmeric Nutraceutical Phase 2
27
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
28 Cyclooxygenase 2 Inhibitors Phase 1
29
Secretin Approved, Investigational 108153-74-8
30
Pancrelipase Approved 53608-75-6
31 pancreatin
32 Gastrointestinal Agents
33 Hormone Antagonists
34 Hormones
35 Hormones, Hormone Substitutes, and Hormone Antagonists
36 serine Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA Completed NCT00510692 Phase 2, Phase 3
2 A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Completed NCT01187901 Phase 2
3 Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia Completed NCT02217332 Phase 2
4 Turmeric Supplementation on Polyp Number and Size in Patients With Familial Adenomatous Polyposis. Not yet recruiting NCT03061591 Phase 2
5 A Pilot Open-Label Crossover Bioavailability Study of Celecoxib in Healthy Volunteers Completed NCT00813241 Phase 1
6 Cancer of the Pancreas Screening Study (CAPS 3) Completed NCT00438906
7 Endocuff for Surveillance of Serrated Polyposis Syndrome Recruiting NCT02592603
8 Prevalence of Small Bowel Polyps in Patients With Sporadic Duodenal Adenomas Recruiting NCT02470416
9 The Cancer of the Pancreas Screening-5 CAPS5)Study Recruiting NCT02000089
10 SB3 Battery Life Observational Study Enrolling by invitation NCT02382705

Search NIH Clinical Center for Cap Polyposis

Genetic Tests for Cap Polyposis

Anatomical Context for Cap Polyposis

MalaCards organs/tissues related to Cap Polyposis:

39
Colon

Publications for Cap Polyposis

Articles related to Cap Polyposis:

(show all 40)
id Title Authors Year
1
Cap Polyposis Masquerading as Inflammatory Bowel Disease in a Child. ( 27437929 )
2016
2
Polypectomy to eradicate cap polyposis with protein-losing enteropathy. ( 25287098 )
2014
3
A case of cap polyposis remission by betamethasone enema after antibiotics therapy including Helicobacter pylori eradication. ( 24949613 )
2014
4
Nine-year follow-up from onset to spontaneous complete remission of cap polyposis. ( 23370743 )
2013
5
Cap-polyposis-like gastropathy with hypoproteinemia treated with H. pylori eradication. ( 24088754 )
2013
6
Cap polyposis mistaken for Crohn's disease: case report and review of literature. ( 22766527 )
2013
7
Rectal cap polyposis masquerading as ulcerative colitis with pseudopolyposis and presenting as chronic anemia: a case study with review of literature. ( 23828750 )
2013
8
Inflammatory cap polyposis in a 42-year-old male. ( 23416507 )
2013
9
Cap polyposis: a rare cause of rectal bleeding in children. ( 23864782 )
2013
10
Cap polyposis and colitis cystica profunda: a rare association. ( 24118052 )
2013
11
Long-term outcome of cap polyposis, with special reference to the effects of steroid therapy. ( 22078102 )
2012
12
Successful management of cap polyposis with eradication of Helicobacter pylori relapsing 15 years after remission on steroid therapy. ( 22333383 )
2012
13
Cap polyposis with protein-losing enteropathy. ( 21869875 )
2011
14
Unusual colon polyps. Diagnosis: Cap polyposis. ( 21878333 )
2011
15
Can the stomach be a target of cap polyposis? ( 20405375 )
2010
16
Remission of cap polyposis maintained for more than three years after infliximab treatment. ( 20431770 )
2009
17
Cap polyposis (CP) which relapsed after remission by avoiding straining at defecation, and was cured by Helicobacter pylori eradication therapy. ( 19952483 )
2009
18
Hypoalbuminaemia and colonic polyps: a case of protein-losing enteropathy with cap polyposis? ( 17847696 )
2007
19
Cap polyposis: an inflammatory disorder or a spectrum of mucosal prolapse syndrome? ( 16099801 )
2005
20
Confined progression of cap polyposis along the anastomotic line, implicating the role of inflammatory responses in the pathogenesis. ( 16111972 )
2005
21
Pedunculated cap polyps preceding the development of cap polyposis: case report. ( 15729261 )
2005
22
Rectal prolapse and cap polyposis: the missing link. ( 15785885 )
2005
23
Possible relationship between Helicobacter pylori infection and cap polyposis of the colon. ( 15610079 )
2004
24
Cap polyposis: further experience and review. ( 15164251 )
2004
25
Successful treatment of cap polyposis with infliximab. ( 15188181 )
2004
26
Spontaneous resolution of cap polyposis: case report. ( 12665781 )
2003
27
Gastrointestinal: cap polyposis. ( 12753160 )
2003
28
Cap polyposis cured by Helicobacter pylori eradication therapy. ( 12108681 )
2002
29
Does metronidazole cure cap polyposis by its antiinflammatory actions instead of by its antibiotic action? A case study. ( 12141801 )
2002
30
Asymptomatic cap polyposis from the sigmoid colon to the cecum. ( 11677493 )
2001
31
Cap polyposis of the colon and rectum: an analysis of endoscopic findings. ( 11293761 )
2001
32
Proximal extension of cap polyposis confirmed by colonoscopy. ( 11522989 )
2001
33
Features of cap polyposis by magnifying colonoscopy. ( 11115917 )
2000
34
A case of "cap polyposis"-like lesion associated with ulcerative colitis: is this a case of cap polyposis? ( 11095366 )
2000
35
Successful treatment of cap polyposis by avoidance of intraluminal trauma: clues to pathogenesis. ( 10950064 )
2000
36
A case of cap polyposis investigated by scintigraphy with human serum albumin labeled with Tc-99m DTPA. ( 9712385 )
1998
37
Abnormal mucus in cap polyposis. ( 9518233 )
1998
38
Protein-losing enteropathy from cap polyposis. ( 7491082 )
1995
39
Cap polyposis occurring in the postoperative course of pelvic surgery. ( 7828996 )
1994
40
Cap polyposis--an unusual cause of diarrhoea. ( 8491408 )
1993

Variations for Cap Polyposis

Expression for Cap Polyposis

Search GEO for disease gene expression data for Cap Polyposis.

Pathways for Cap Polyposis

GO Terms for Cap Polyposis

Cellular components related to Cap Polyposis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 ALB MUC3A MUC4 MUC5AC
2 Golgi lumen GO:0005796 8.92 MUC2 MUC3A MUC4 MUC5AC

Biological processes related to Cap Polyposis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC2 MUC3A MUC4 MUC5AC
2 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC4
3 O-glycan processing GO:0016266 8.92 MUC2 MUC3A MUC4 MUC5AC

Molecular functions related to Cap Polyposis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.96 MUC3A MUC5AC
2 extracellular matrix constituent, lubricant activity GO:0030197 8.62 MUC3A MUC4

Sources for Cap Polyposis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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