MCID: CPL005
MIFTS: 36

Capillary Disease malady

Categories: Cardiovascular diseases

Aliases & Classifications for Capillary Disease

Aliases & Descriptions for Capillary Disease:

Name: Capillary Disease 12 14
Disease of Capillaries 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1271
ICD10 33 I78 I78.9
ICD9CM 35 448
UMLS 69 C0155765

Summaries for Capillary Disease

Disease Ontology : 12 A vascular disease that is located in the capillaries.

MalaCards based summary : Capillary Disease, also known as disease of capillaries, is related to sarcoma and cataract. An important gene associated with Capillary Disease is IL2 (Interleukin 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Photodynamic therapy-induced NF-kB survival signaling. The drugs Bosentan and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include endothelial and the capillaries, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 71 Capillaries (/ˈkæpᵻlɛriz/ in US; /kəˈpɪləriz/ in UK) are the smallest of a body\'s blood... more...

Related Diseases for Capillary Disease

Diseases related to Capillary Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
id Related Disease Score Top Affiliating Genes
1 sarcoma 10.2 CSF2 IL2
2 cataract 10.2 ALB CSF2
3 exudative vitreoretinopathy 2, x-linked 10.2 ALB CSF2
4 necrotizing gastritis 10.2 ALB CSF2
5 cerebral sarcoidosis 10.1 ALB IL2
6 lung combined large cell neuroendocrine carcinoma 10.1 IL2 SERPING1
7 submucous uterine fibroid 10.1 ALB ANGPT2
8 charcot-marie-tooth disease 2a2b 10.1 ALB SERPING1
9 hypersensitivity syndrome, carbamazepine-induced 10.1 ALB ANGPT2
10 pharc syndrome 10.1 CSF2 IL2
11 labyrinthine bilateral reactive loss 10.1 ALB CSF2 IL2
12 anterior foramen magnum meningioma 10.1 ALB CSF2 IL2
13 fallopian tube endometriosis 10.1 ALB CSF2 IL2
14 membranoproliferative glomerulonephritis 10.1 ALB CSF2 IL2
15 dyskeratosis congenita 10.1 ALB IL36RN
16 mansonelliasis 10.0 ALB IL2
17 vascular disease 10.0 ALB ATP4A
18 pleomorphic rhabdomyosarcoma 10.0 ALB ATP4A
19 porencephaly, cerebellar hypoplasia, and internal malformations 10.0 ALB ATP4A
20 vernal conjunctivitis 10.0 ALB ANGPT2
21 retinal ischemia 10.0 CSF2 IL2
22 enamel erosion 10.0 ATP4A CTC1
23 inhalation anthrax 10.0 ALB ATP4A
24 angelucci's syndrome 10.0 ALB ATP4A
25 breast cystic hypersecretory carcinoma 9.9 ALB ATP4A
26 hereditary hemorrhagic telangiectasia 9.9
27 immunodeficiency due to defect in mapbp-interacting protein 9.8 ALB ANGPT2 CSF2 IL2
28 systemic capillary leak syndrome 9.7
29 chronic gonococcal salpingitis 8.8 ALB ANGPT2 ATP4A CSF2 CTC1 IL2

Graphical network of the top 20 diseases related to Capillary Disease:



Diseases related to Capillary Disease

Symptoms & Phenotypes for Capillary Disease

MGI Mouse Phenotypes related to Capillary Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ALB ANGPT2 ATP4A CSF2 CTC1 IL2
2 immune system MP:0005387 9.5 ANGPT2 ATP4A CSF2 CTC1 IL2 IL36RN
3 mortality/aging MP:0010768 9.23 ALB ANGPT2 ATP4A CSF2 CTC1 IL2

Drugs & Therapeutics for Capillary Disease

Drugs for Capillary Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 583)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 4,Phase 2 147536-97-8 104865
2
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
3
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
4
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
6
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 14219 4091
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 53-03-2 5865
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-24-8 5755
10
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
11
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
12
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
13
Insulin Lispro Approved Phase 4,Phase 3,Phase 2 133107-64-9
14
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
15
Artemether Approved Phase 4 71963-77-4 119380 68911
16
Lumefantrine Approved Phase 4 82186-77-4 6437380
17
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
18
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
19
Menthol Approved Phase 4,Phase 2,Phase 3,Early Phase 1 2216-51-5 16666
20
Nitric Oxide Approved Phase 4 10102-43-9 145068
21
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
22
Insulin Glargine Approved Phase 4,Phase 3,Phase 2 160337-95-1
23
Gliclazide Approved Phase 4,Phase 2 21187-98-4 3475
24
Liraglutide Approved Phase 4,Phase 2 204656-20-2
25
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
26
Dobutamine Approved Phase 4,Phase 2 34368-04-2 36811
27
Conivaptan Approved, Investigational Phase 4 210101-16-9 151171
28
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
29
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
30
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
31
Treprostinil Approved, Investigational Phase 4,Phase 2,Phase 3 81846-19-7 54786 6918140
32
Eplerenone Approved Phase 4,Phase 3 107724-20-9 150310 443872
33
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
34
Ciprofloxacin Approved, Investigational Phase 4,Phase 1 85721-33-1 2764
35
Insulin Detemir Approved Phase 4,Phase 3 169148-63-4 5311023
36
Dimenhydrinate Approved Phase 4 523-87-5 441281
37
Bisoprolol Approved Phase 4 66722-44-9 2405
38
Candesartan Approved Phase 4 139481-59-7 2541
39
Captopril Approved Phase 4 62571-86-2 44093
40
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
41
Cilazapril Approved Phase 4 88768-40-5, 92077-78-6 56329 56330
42
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
43
Enalaprilat Approved Phase 4 76420-72-9 6917719
44
Eprosartan Approved Phase 4 133040-01-4 5281037
45
Fosinopril Approved Phase 4 98048-97-6 55891
46
Lisinopril Approved, Investigational Phase 4 83915-83-7 5362119
47
Losartan Approved Phase 4 114798-26-4 3961
48
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
49
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
50
Quinapril Approved, Investigational Phase 4 85441-61-8 54892

Interventional clinical trials:

(show top 50) (show all 909)
id Name Status NCT ID Phase
1 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4
2 Microvascular Reperfusion Utilizing Sonothrombolysis in Acute Myocardial Infarction (MRUSMI TRIAL) Unknown status NCT02170103 Phase 4
3 Normoglycemia and Neurological Outcome Unknown status NCT01137773 Phase 4
4 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4
5 Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema Unknown status NCT02399657 Phase 4
6 Valsartan Optimal Therapy Against Elevated Home Blood Pressure Research(VOYAGER)Study Completed NCT00460213 Phase 4
7 Metformin in Chronic Obstructive Pulmonary Disease Completed NCT01247870 Phase 4
8 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
9 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4
10 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4
11 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
12 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4
13 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4
14 Glargine Versus NPH in Patients With Chronic Kidney Disease Completed NCT02451917 Phase 4
15 Antidiabetic Effects on Intrahepatic Fat Completed NCT03068065 Phase 4
16 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4
17 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4
18 Vascular Endothelial Growth Factor in Stage V ROP Completed NCT00500396 Phase 4
19 Estimated Echocardiographic Pulmonary Capillary Wedge Pressure in Heart Failure Completed NCT01738659 Phase 4
20 VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension Completed NCT01889966 Phase 4
21 An Open-Label Uncontrolled Study of the Safety and Efficacy of Ambrisentan in Participants With Exercise-Induced Pulmonary Arterial Hypertension (PAH) Completed NCT01338636 Phase 4
22 Efficacy and Safety of Treatment With Simdax® Versus Dobutrex® in Decompensated Heart Failure Patients. Completed NCT00219388 Phase 4
23 Effects on Exercise Hemodynamics of Vasopressin Blockade by Conivaptan Infusion in Heart Failure Patients Completed NCT01752543 Phase 4
24 Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH. Completed NCT01800292 Phase 4
25 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
26 Testing Ascensia Contour Glucometer for the Measurement of Blood Glucose Completed NCT00502359 Phase 4
27 Needle Length In Obese Insulin-Using Diabetic Subjects Completed NCT00541372 Phase 4
28 Telephone Based Management of Hyperlipidemia Completed NCT01212159 Phase 4
29 Effect of Short-Term Intensive Insulin Sequential Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients Completed NCT01776788 Phase 4
30 Emergency Department Rapid Intravenous Rehydration (RIVR) for Pediatric Gastroenteritis Completed NCT00392145 Phase 4
31 Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus. Completed NCT00770445 Phase 4
32 DPP IV Inhibition Facilitates Healing of Chronic Foot Ulcers in Type 2 Diabetes Completed NCT01472432 Phase 4
33 Safety and Tolerability of Rapid Dose Titration of Subcutaneous Remodulin® Therapy in PAH Subjects (RAPID) Completed NCT02847260 Phase 4
34 PRELIMINARY EVALUATION OF PHARMACOLOGICAL LOWERING OF AGEs Recruiting NCT02249897 Phase 4
35 NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients Recruiting NCT02817360 Phase 4
36 Immunomodulation With Romiplostim in Young Adults With ITP Recruiting NCT02760251 Phase 4
37 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Recruiting NCT02556814 Phase 4
38 Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS Recruiting NCT02574403 Phase 4
39 Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease Recruiting NCT02752191 Phase 4
40 Lumefantrine in Venous Plasma Versus Dried Capillary Blood Spot Recruiting NCT02742285 Phase 4
41 Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis. Recruiting NCT02618213 Phase 4
42 Aldosterone Antagonism and Microvascular Function Recruiting NCT01887119 Phase 4
43 Ramipril Treatment of Claudication Recruiting NCT02842424 Phase 4
44 Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS Recruiting NCT02276066 Phase 4
45 Renoprotective Effects of Dapagliflozin in Type 2 Diabetes Recruiting NCT02682563 Phase 4
46 Rituximab in Recurrent IgA Nephropathy Recruiting NCT02571842 Phase 4
47 Syringes Replacement for Insulin Application for Pens Device in a Population of Elderly Patients With Type 2 Diabetes: Multifactorial Intervention to Improve Glycemic Control Recruiting NCT02517242 Phase 4
48 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Recruiting NCT02967341 Phase 4
49 ß-Cell Function and Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients With Moderate Hyperglycemia Recruiting NCT01717911 Phase 4
50 Comparison of Two Titration Programs of Adding Insulin Detemir to OADs in Poorly Controlled Type 2 Diabetes Recruiting NCT01281605 Phase 4

Search NIH Clinical Center for Capillary Disease

Genetic Tests for Capillary Disease

Anatomical Context for Capillary Disease

MalaCards organs/tissues related to Capillary Disease:

39
Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Capillary Disease:

18
The Capillaries

Publications for Capillary Disease

Articles related to Capillary Disease:

id Title Authors Year
1
Growth hormone, sorbitol, and diabetic capillary disease. ( 4102056 )
1971
2
Growth hormone, sorbitol, and diabetic capillary disease. ( 4100908 )
1971

Variations for Capillary Disease

Expression for Capillary Disease

Search GEO for disease gene expression data for Capillary Disease.

Pathways for Capillary Disease

GO Terms for Capillary Disease

Cellular components related to Capillary Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ALB ANGPT2 CSF2 IL2 IL36RN SERPING1
2 extracellular space GO:0005615 9.17 ALB ANGPT2 ATP4A CSF2 IL2 IL36RN
3 platelet alpha granule lumen GO:0031093 9.16 ALB SERPING1

Biological processes related to Capillary Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 CSF2 IL2
2 positive regulation of DNA replication GO:0045740 8.96 CSF2 CTC1
3 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 8.62 CSF2 IL2

Molecular functions related to Capillary Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CSF2 IL2 IL36RN

Sources for Capillary Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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