MCID: CPL006
MIFTS: 51

Capillary Hemangioma malady

Genetic diseases, Skin diseases, Cardiovascular diseases, Eye diseases, Fetal diseases, Rare diseases categories

Aliases & Classifications for Capillary Hemangioma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt
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Aliases & Descriptions for Capillary Hemangioma:

Name: Capillary Hemangioma 8 10
Strawberry Nevus of Skin 8 61
Cellular Hemangioma of Infancy 8
Congenital Vascular Hamartoma 8
Congenital Vascular Naevus 8
Strawberry Haemangioma 8
 
Hemangioma, Cavernous 61
Infantile Hemangioma 8
Hemangioma Capillary 44
Juvenile Hemangioma 8
Strawberry Nevus 8


Classifications:



External Ids:

Disease Ontology8 DOID:2725
MeSH33 D018324
NCIt39 C6645

Summaries for Capillary Hemangioma

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Wikipedia:64 A capillary hemangioma (also known as an \"Infantile hemangioma,\" \"Strawberry hemangioma\", and... more...

MalaCards based summary: Capillary Hemangioma, also known as strawberry nevus of skin, is related to pyogenic granuloma and renal cell carcinoma. An important gene associated with Capillary Hemangioma is TEK (TEK tyrosine kinase, endothelial), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and African trypanosomiasis. The compounds ponatinib and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and lung, and related mouse phenotypes are muscle and integument.

Related Diseases for Capillary Hemangioma

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Diseases in the Capillary Hemangioma family:

Hemangioma, Capillary Infantile Familial Capillary Hemangioma

Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1pyogenic granuloma31.2SLC2A1, CD34, TEK
2renal cell carcinoma30.8VEGFA
3hemangioma30.7TEK, VEGFA, HBA1, HBA2, KDR, CD34
4congenital heart disease30.1VEGFA, HBA1, HBA2
5hemangioblastoma29.8SLC2A1, KDR, VEGFA
6retinitis10.9
7breast capillary hemangioma10.4
8retinal detachment10.4
9skin hemangioma10.3
10phace syndrome10.3
11endotheliitis10.3
12familial capillary hemangioma10.3
13hemoglobin h disease, nondeletional10.3HBA1, HBA2
14epithelioid sarcoma10.2HBA2, HBA1
15thalassemias, alpha-10.2HBA1, HBA2
16hemangioma, capillary infantile10.2
17roberts syndrome10.2
18smith-lemli-opitz syndrome10.2
19craniolenticulosutural dysplasia10.2
20rubinstein-taybi syndrome10.2
21capillary malformations, congenital, 1, somatic, mosaic10.2
22astigmatism10.2
23cavernous hemangioma10.2
24cervicitis10.2
25mediastinitis10.2
26tufted angioma10.2
27sickle cell anemia10.2HBA2, HBA1
28thalassemia10.2HBA1, HBA2
29myofibroma10.2
30dental caries10.2
31polycythemia10.2CD34, HBA2
32meningioma, familial10.2SLC2A1, CD34
33cerebral arteriovenous malformation10.1TEK, KDR
34malignant peripheral nerve sheath tumor10.1SLC2A1, CD34
35classic kaposi sarcoma10.1CD34, HBA2, HBA1
36grade iii astrocytoma10.1VEGFA, TYMP
37lymphangioma10.1CD34, HBA2, HBA1
38hemangiopericytoma10.1CD34, HBA2, HBA1
39thrombocytopenia-absent radius syndrome10.1
40gapo syndrome10.1
41asthma10.1
42multiple pterygium syndrome, lethal type10.1
43perlman syndrome10.1
44von hippel-lindau syndrome10.1
45robinow syndrome, autosomal dominant10.1
46c syndrome10.1
47kahrizi syndrome10.1
48parkes weber syndrome10.1
49capillary malformation-arteriovenous malformation10.1
50beckwith-wiedemann syndrome10.1

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to capillary hemangioma

Symptoms for Capillary Hemangioma

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Drugs & Therapeutics for Capillary Hemangioma

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Drug clinical trials:

Search ClinicalTrials for Capillary Hemangioma

Search NIH Clinical Center for Capillary Hemangioma

Genetic Tests for Capillary Hemangioma

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Anatomical Context for Capillary Hemangioma

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MalaCards organs/tissues related to Capillary Hemangioma:

31
Skin, Spinal cord, Lung, Bone, Retina, Testis, Liver, Endothelial, Trachea, Spleen, Kidney, Cervix, Brain, Heart, Small intestine, Salivary gland, Breast, Prostate, Tongue

Animal Models for Capillary Hemangioma or affiliated genes

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MGI Mouse Phenotypes related to Capillary Hemangioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3KDR, HBA2, VEGFA, TEK
2MP:00107717.6VEGFA, HBA2, KDR, TAP1, CD34
3MP:00053977.4TEK, VEGFA, HBA2, KDR, TAP1, CD34
4MP:00036317.1TEK, TYMP, VEGFA, KDR, TAP1, SLC2A1
5MP:00107687.1TEK, VEGFA, HBA1, HBA2, KDR, TAP1
6MP:00053846.9SLC2A1, TEK, TYMP, VEGFA, HBA2, KDR
7MP:00053766.9TEK, TYMP, VEGFA, HBA2, KDR, CD34

Publications for Capillary Hemangioma

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Articles related to Capillary Hemangioma:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Lobular capillary hemangioma of the trachea. (25644803)
2015
2
Photodynamic therapy for juxtapapillary retinal capillary hemangioma. (24716060)
2014
3
Intradural extramedullary capillary hemangioma in the upper thoracic spine: a review of the literature. (25045565)
2014
4
Management of a bulky capillary hemangioma in the parapharyngeal space with minimally invasive surgery. (24481164)
2014
5
Nasal lobular capillary hemangioma. (24228209)
2013
6
A suspicious breast lesion detected by dynamic contrast-enhanced MRI and pathologically confirmed as capillary hemangioma: a case report and literature review. (24265560)
2013
7
Strawberries on the brain-intracranial capillary hemangioma: two case reports and systematic literature review in children and adults. (23247022)
2013
8
Intravenous lobular capillary hemangioma occurring in the cephalic vein of a 39-year-old adult. (24151094)
2013
9
Intraneural capillary hemangioma: a rare cause of proximal median neuropathy. (24441340)
2013
10
Intravenous Lobular Capillary Hemangioma Occurring after Needle Insertion during Routine Health Checkup. (23641295)
2013
11
Purely Cutaneous Rosai-Dorfman disease (CRDD) co-existed with capillary hemangioma successfully treated with intralesional corticosteroid. (24164002)
2013
12
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
13
Capillary hemangioma treatment. (22944499)
2012
14
Rapid regrowth of a capillary hemangioma of the thoracic spinal cord. (23006883)
2012
15
Aortic coarctation in the presence of capillary hemangioma. (21764546)
2011
16
Incidentally discovered capillary hemangioma of the prostate. (22018156)
2011
17
Capillary hemangioma in a rib presenting as large pleural effusion. (21440110)
2011
18
Reduction in astigmatism using propranolol as first-line therapy for periocular capillary hemangioma. (20970771)
2011
19
Lobular capillary hemangioma in the soft tissue of the finger: sonographic findings. (20428860)
2010
20
Intravenous lobular capillary hemangioma. (20494549)
2010
21
Jejunal capillary hemangioma treated by using double-balloon endoscopy (with video). (20546731)
2010
22
Pyogenic granuloma: lobular capillary hemangioma in the upper lip of a 24-month-old child: case report. (19941768)
2009
23
A rare vascular tumor of the external auditory canal: the capillary hemangioma. (19860637)
2009
24
Intradural capillary hemangioma of the cauda equina. (18663441)
2008
25
Congenital enormous high flow capillary hemangioma of forearm. (18309319)
2008
26
Ovarian capillary hemangioma presenting as pseudo-Meigs' syndrome: a case report. (17478373)
2007
27
Unusual location of a capillary hemangioma: inguinal location. (17576501)
2007
28
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
29
Capillary hemangioma of the tympanic membrane. (16137537)
2005
30
Retinal capillary hemangioma in von Hippel-Lindau disease. (16049535)
2005
31
Capillary hemangioma of the endometrium: a case report and review of the literature. (16196525)
2005
32
Lobular capillary hemangioma of the nasal cavity. (16089224)
2005
33
Thoracic intradural extramedullary capillary hemangioma. (15313728)
2004
34
Childhood capillary hemangioma presenting as infantile perianal protrusion. (14657638)
2003
35
Capillary hemangioma of the calvaria. (12845203)
2003
36
Lobular capillary hemangioma of the oral mucosa: clinicopathological study of 43 cases with a special reference to immunohistochemical characterization of the vascular elements. (12558863)
2003
37
Treatment of retinal capillary hemangioma. (12359597)
2002
38
Spinal intradural extramedullary capillary hemangioma: MR imaging findings. (11290503)
2001
39
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
40
Neurologic toxicity associated with interferon alfa treatment of capillary hemangioma. (10532761)
1997
41
Capillary hemangioma--report of a case. (9522754)
1996
42
Capillary hemangioma of the vocal cord. (7628325)
1995
43
Nasal glioma masquerading as a capillary hemangioma. (8323905)
1993
44
Capillary hemangioma of the optic disc associated with a total retinal detachment. (8259247)
1993
45
Treatment of a massive orbital-capillary hemangioma with interferon alfa-2b: short-term results. (1417530)
1992
46
Capillary hemangioma in the cauda equina: neuroradiological findings. (1749484)
1991
47
Treatment of a capillary hemangioma with the flashlamp pumped-dye laser. (2298954)
1990
48
Pathologic quiz case 2. Intramuscular capillary hemangioma. (3790291)
1987
49
Intraosseous capillary hemangioma of the frontal bone. (3591881)
1987
50
Intralesional corticosteroid injection for capillary hemangioma of the eyelid. (3765021)
1986

Variations for Capillary Hemangioma

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Expression for genes affiliated with Capillary Hemangioma

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Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for genes affiliated with Capillary Hemangioma

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Pathways related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HBA2, HBA1
29.6HBA2, HBA1
39.6HBA1, HBA2
4
Show member pathways
9.6HBA1, HBA2
59.5KDR, TEK
69.1SLC2A1, VEGFA
79.1VEGFA, SLC2A1
89.1TEK, TYMP, KDR
99.0KDR, VEGFA
109.0KDR, VEGFA
11
Show member pathways
9.0KDR, VEGFA
12
Show member pathways
VEGFR1 specific signals36
9.0KDR, VEGFA
13
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
9.0VEGFA, KDR
14
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.0KDR, VEGFA
159.0VEGFA, KDR
169.0KDR, VEGFA
17
Show member pathways
9.0VEGFA, KDR
189.0KDR, VEGFA
198.8SLC2A1, VEGFA, TEK
20
Show member pathways
8.7TEK, VEGFA, KDR
218.7TEK, VEGFA, KDR
22
Show member pathways
Angiogenesis36
8.7KDR, VEGFA, TEK
238.5SLC2A1, KDR, VEGFA

Compounds for genes affiliated with Capillary Hemangioma

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Compounds related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1ponatinib50 1110.9KDR, TEK
2capecitabine44 50 1111.6VEGFA, TYMP
3vinorelbine44 50 1111.6TYMP, VEGFA
4fluorouracil50 1110.5TYMP, VEGFA
5cobalt chloride449.5VEGFA, SLC2A1
6azd 2171449.5VEGFA, KDR
7ptk787449.4VEGFA, KDR
8su6668449.4KDR, VEGFA
9zd6474449.4KDR, VEGFA
10ifn-alpha449.4TYMP, TAP1
11axitinib60 44 1111.4KDR, VEGFA
12su5416449.4VEGFA, KDR
13sunitinib44 50 1111.4VEGFA, KDR
14marimastat44 60 1111.3VEGFA, KDR
15infliximab44 50 1111.3TEK, VEGFA
16cetuximab44 50 1111.3KDR, VEGFA
17vandetanib50 1110.2TEK, VEGFA, KDR
18agar449.1KDR, CD34, SLC2A1
19regorafenib50 1110.1KDR, VEGFA, TEK
20oxaliplatin44 50 1111.1VEGFA, TYMP
21wortmannin449.1KDR, SLC2A1, TYMP
22sorafenib44 50 1111.1VEGFA, KDR
23taxane449.1KDR, VEGFA, TYMP
24erlotinib44 50 1111.1VEGFA, TYMP, KDR
25leucovorin44 50 1111.0VEGFA, KDR, TYMP
26trastuzumab44 50 1111.0VEGFA, KDR
27gemcitabine44 50 1111.0TYMP, KDR, VEGFA
28docetaxel44 50 60 1112.0KDR, VEGFA, TYMP
29atp44 2810.0TAP1, HBA2, TYMP, SLC2A1
30cyclophosphamide44 50 1111.0TYMP, VEGFA, KDR
31prostacyclin449.0TYMP, VEGFA, KDR
32tamoxifen44 50 28 1111.9VEGFA, KDR, TYMP
33paclitaxel44 50 1110.9VEGFA, KDR, TYMP
34egcg448.9VEGFA, KDR, SLC2A1
35actinomycin d448.9VEGFA, TYMP, SLC2A1
36cysteine448.8TYMP, TEK, SLC2A1, KDR
37oxygen44 249.8HBA1, HBA2, SLC2A1, TEK, TYMP
38doxorubicin44 50 1110.8VEGFA, KDR, TYMP
39rapamycin448.8VEGFA, SLC2A1, KDR
40matrigel448.7KDR, VEGFA, TEK, TYMP
41genistein44 28 60 1 24 1113.6SLC2A1, VEGFA, KDR
42thymidine44 249.6HBA2, KDR, CD34, TEK, TYMP
435fluorouracil448.5SLC2A1, TYMP, VEGFA, KDR
44ly294002448.5TYMP, SLC2A1, KDR, VEGFA
45cisplatin44 50 60 1111.5SLC2A1, KDR, VEGFA, TYMP
46estrogen448.0SLC2A1, CD34, TYMP, KDR, VEGFA
47paraffin447.7TEK, TYMP, VEGFA, SLC2A1, CD34, KDR
48vegf447.7TEK, TYMP, VEGFA, KDR, CD34, SLC2A1
49tyrosine447.2TYMP, SLC2A1, CD34, KDR, HBA2, VEGFA

GO Terms for genes affiliated with Capillary Hemangioma

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Cellular components related to Capillary Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:00099259.6CD34, TEK

Biological processes related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1endothelial cell proliferationGO:00019359.9CD34, TEK
2negative regulation of endothelial cell apoptotic processGO:020003529.8KDR, TEK
3endothelium developmentGO:00031589.7KDR, CD34
4positive regulation of intracellular signal transductionGO:019025339.7TEK, VEGFA
5positive regulation of vasculogenesisGO:020012149.6KDR, CD34
6positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6KDR, TEK
7surfactant homeostasisGO:00431299.3VEGFA, KDR
8positive regulation of peptidyl-serine phosphorylationGO:00331389.3TEK, VEGFA
9positive regulation of positive chemotaxisGO:00509279.3KDR, VEGFA
10cell migration involved in sprouting angiogenesisGO:00020429.3KDR, VEGFA
11cellular response to vascular endothelial growth factor stimulusGO:00359249.3KDR, VEGFA
12vascular endothelial growth factor receptor signaling pathwayGO:00480109.3VEGFA, KDR
13transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.2KDR, TEK
14branching morphogenesis of an epithelial tubeGO:00487549.2VEGFA, KDR
15positive regulation of mesenchymal cell proliferationGO:00020539.2KDR, VEGFA
16cell maturationGO:00484699.2VEGFA, KDR
17ovarian follicle developmentGO:00015419.1KDR, VEGFA
18positive regulation of focal adhesion assemblyGO:00518949.1KDR, VEGFA, TEK
19positive regulation of endothelial cell migrationGO:00105959.1TEK, KDR, VEGFA
20positive regulation of endothelial cell proliferationGO:00019389.1KDR, VEGFA, TEK
21positive regulation of protein phosphorylationGO:00019349.0TEK, KDR, VEGFA
22vasculogenesisGO:00015708.9KDR, VEGFA
23negative regulation of apoptotic processGO:00430668.7KDR, VEGFA, TEK
24angiogenesisGO:00015258.7KDR, VEGFA, TYMP, TEK
25positive regulation of angiogenesisGO:00457668.6VEGFA, CD34, KDR, TEK

Molecular functions related to Capillary Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.5KDR, TEK
2growth factor bindingGO:00198389.2KDR, TEK
3platelet-derived growth factor receptor bindingGO:00051619.1VEGFA, TYMP

Sources for Capillary Hemangioma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet