MCID: CPL006
MIFTS: 57

Capillary Hemangioma malady

Skin diseases, Cardiovascular diseases categories

Summaries for Capillary Hemangioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A capillary hemangioma (also known as an \"Infantile hemangioma,\" \"Strawberry hemangioma\", and... more...

MalaCards: Capillary Hemangioma, also known as strawberry nevus of skin, is related to hemangioma and retinal disease. An important gene associated with Capillary Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are Tyrosine Kinases / Adaptors and Akt Signaling Pathway . The compounds estrogen and vegfc have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and spinal cord, and related mouse phenotypes are nervous system and integument.

Aliases & Classifications for Capillary Hemangioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Cardiovascular diseases


Aliases & Descriptions:

capillary hemangioma 8 10
strawberry nevus of skin 8 60
cellular hemangioma of infancy 8
congenital vascular hamartoma 8
congenital vascular naevus 8
strawberry haemangioma 8
infantile hemangioma 8
hemangioma capillary 44
juvenile hemangioma 8
strawberry nevus 8


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Disease Ontology8 DOID:2725
MeSH34 D018324
NCIt39 C6645

Related Diseases for Capillary Hemangioma

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17GeneCards, 18GeneDecks
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Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.8TEK, SLC2A1, KDR, HBA1, HBA2, CD34
2retinal disease30.8F8, VEGFA, KDR, SLC2A1, TEK
3hemangioma, capillary infantile30.2FLT4, KDR
4hemangioma, capillary infantile, somatic30.2FLT4, KDR
5klippel-trenaunay syndrome30.2FLT4
6pyogenic granuloma30.2FLT4, CD34, SLC2A1, TEK
7hepatitis30.0TYMP, F8
8hemangioblastoma30.0VEGFA, KDR, SLC2A1
9renal clear cell carcinoma30.0SLC2A1, KDR, VEGFA
10meningioma30.0CD34, SLC2A1
11kaposi's sarcoma30.0FLT4, VEGFA, CD34, KDR, TEK
12retinopathy of prematurity30.0VEGFA
13retinoblastoma29.9PROM1, FLT4
14retinitis10.8
15capillary disease10.6
16von hippel-lindau disease10.6
17hemangioma of orbit10.5
18cavernous hemangioma10.5
19acquired hemangioma10.4
20hemangioma of lung10.4
21hemangioma of liver10.3
22breast capillary hemangioma10.3
23giant hemangioma10.3
24central nervous system hemangioma10.3
25retinal detachment10.3
26skin hemangioma10.3
27intramuscular hemangioma10.2
28astigmatism10.2
29cervicitis10.2
30mediastinitis10.2
31renal cell carcinoma10.2
32sclerosing hemangioma10.2
33capillary malformations, congenital, 1, somatic, mosaic10.2
34melorheostosis with osteopoikilosis10.2
35dental caries10.1
36giant infantile hemangioma10.1
37hemangioma of subcutaneous tissue10.0
38thrombocytopenia-absent radius syndrome10.0
39smith-lemli-opitz syndrome10.0
40cardiac tamponade10.0
41williams-beuren syndrome10.0
42rubinstein-taybi syndrome10.0
43gastric hemangioma10.0
44klinefelter's syndrome10.0
45hemangioma of spleen10.0
46bannayan-riley-ruvalcaba syndrome10.0
47nasal cavity inverting papilloma10.0
48incontinentia pigmenti achromians10.0
49cryptorchidism10.0
50radiculopathy10.0

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to capillary hemangioma

Clinical Features for Capillary Hemangioma

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Drugs & Therapeutics for Capillary Hemangioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Capillary Hemangioma

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Anatomical Context for Capillary Hemangioma

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32MalaCards
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MalaCards organs/tissues related to Capillary Hemangioma:

32
Skin, Lung, Spinal cord, Liver, Endothelial, Testis, Retina, Bone, Cervix, Trachea, Lymph node, Kidney, Spleen, Tongue, Prostate, Salivary gland, Small intestine, Brain, Breast, Heart

Animal Models for Capillary Hemangioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Capillary Hemangioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.6PROX1, TYMP, TAP1, SLC2A1
2MP:00107718.5VEGFA, CD34, TAP1, KDR
3MP:00030128.4SLC2A1, KDR, VEGFA, PROM1, FLT4
4MP:00053768.3F8, PROX1, CD34, HBA2
5MP:00053876.9F8, FLT4, PROX1, VEGFA, TYMP, CD34
6MP:00053976.9F8, PROX1, VEGFA, CD34, HBA2, TAP1
7MP:00053786.8FLT4, PROM1, PROX1, VEGFA, HBA2, KDR
8MP:00053846.3TYMP, VEGFA, PROX1, PROM1, CD34, HBA2
9MP:00107686.0TEK, F8, FLT4, PROM1, PROX1, VEGFA

Publications for Capillary Hemangioma

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50PubMed
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Articles related to Capillary Hemangioma:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Spinal lobular capillary hemangioma with an intramedullary component. (23924752)
2014
2
Nasal lobular capillary hemangioma. (24228209)
2013
3
Primary Surgical Excision for Pediatric Orbital Capillary Hemangioma. (24117453)
2013
4
Treatment of infantile capillary hemangioma of the eyelid with systemic propranolol. (22967870)
2013
5
Capillary cavernous hemangioma of the lymph node. (23696945)
2013
6
A case of capillary hemangioma of lingular segmental bronchus in adult. (23946758)
2013
7
Testicular capillary hemangioma presenting as an incidental contralateral lesion in a child with cryptorchidism. (22990059)
2012
8
Intracranial capillary hemangioma: a description of four cases. (22120265)
2012
9
Lobular capillary hemangioma in the posterior trachea: a rare cause of hemoptysis. (23227409)
2012
10
Capillary hemangioma of the middle ear: one case report and review of the literature. (22953107)
2012
11
Multifocal capillary hemangioma (hemangiomatosis) of the spleen. (22495727)
2012
12
Adult capillary hemangioma. (22893069)
2012
13
Aortic coarctation in the presence of capillary hemangioma. (21764546)
2011
14
Antenatal ultrasonographic features of fetal capillary hemangioma in the posterior fossa. (21040213)
2011
15
Evaluation of intralesional propranolol for periocular capillary hemangioma. (21887095)
2011
16
Jejunal capillary hemangioma treated by using double-balloon endoscopy (with video). (20546731)
2010
17
Lobular capillary hemangioma of the trachea: the second case. (23168891)
2010
18
Does hepatic adult capillary hemangioma exist? (20037850)
2010
19
Atypical lymphoid proliferation in capillary hemangioma: a finding related to bacterial infection? (19922482)
2010
20
Acute postpartum paraplegia caused by spinal extradural capillary hemangioma. (19782976)
2010
21
Morning glory disk anomaly with ipsilateral capillary hemangioma, agenesis of the internal carotid artery, and Horner syndrome: a variant of PHACES syndrome? (18620881)
2008
22
Clinical challenges and images in GI. Capillary hemangioma of small intestine. (17484862)
2007
23
Capillary hemangioma of the middle ear. (17418272)
2007
24
Retinal capillary hemangioma treated with verteporfin photodynamic therapy and intravitreal triamcinolone acetonide. (17804927)
2007
25
Spinal intradural capillary hemangioma. (16876637)
2006
26
Capillary hemangioma of the endometrium: a case report and review of the literature. (16196525)
2005
27
Agenesis of bilateral internal carotid arteries and posterior fossa abnormality in a patient with facial capillary hemangioma: presumed incomplete phenotypic expression of PHACE syndrome. (16286414)
2005
28
Lobular capillary hemangioma of the nasal cavity in child. (15917177)
2005
29
Clinical case report: capillary hemangioma. (15833013)
2005
30
Disseminated lobular capillary hemangioma: two case reports. (16471465)
2005
31
Capillary hemangioma of the calvaria. (12845203)
2003
32
Solitary retinal capillary hemangioma: lack of genetic evidence for von Hippel-Lindau disease. (11910555)
2002
33
Hemangioma of the testis: report of unusual occurrences of cavernous hemangioma in a fetus and capillary hemangioma in an older man. (11294992)
2001
34
Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ. (9446823)
1998
35
Ruthenium-106 brachytherapy for peripheral retinal capillary hemangioma. (9709747)
1998
36
Testicular capillary hemangioma: an unusual diagnosis suggested by duplex color flow ultrasound findings. (9120981)
1997
37
Treatment of periocular capillary hemangioma with topical clobetasol propionate. (9098309)
1995
38
Treatment of a massive orbital-capillary hemangioma with interferon alfa-2b: short-term results. (1417530)
1992
39
Congenital oculomotor nerve palsy, cerebellar hypoplasia, and facial capillary hemangioma. (1575222)
1992
40
Capillary hemangioma of the maxilla. A report of two cases in which angiography and embolization were used. (2216353)
1990
41
Capillary hemangioma (strawberry mark) of infancy: comparison of argon and Nd:YAG laser treatment. (2734405)
1989
42
Pathologic quiz case 2. Intramuscular capillary hemangioma. (3790291)
1987
43
Visceral intravascular capillary hemangioma. (3827549)
1987
44
Intralesional corticosteroid injection for capillary hemangioma of the eyelid. (3765021)
1986
45
Capillary hemangioma of the sphenoid bone. (6701543)
1984
46
Lobular capillary hemangioma of the esophagus. A case report and review of the literature. (6670559)
1983
47
Subcutaneous granuloma pyogenicum. Lobular capillary hemangioma. (7059197)
1982
48
Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. (7435775)
1980
49
XXY Klinefelter's syndrome with bilateral cryptochidism, obesity, multiple capillary hemangiomas and telangiectasia. (23441)
1978
50
Conservative management of cutaneous capillary hemangioma. (13943117)
1963

Genetic Variations for Capillary Hemangioma

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Expression for genes affiliated with Capillary Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for genes affiliated with Capillary Hemangioma

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4Cell Signaling Technology, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 49PharmGKB, 55SinoBiological, 53Reactome, 29KEGG
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Compounds for genes affiliated with Capillary Hemangioma

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4F8
2vegfc2810.3KDR, FLT4
3vegfe2810.3KDR, FLT4
4Pazopanib1110.1KDR, FLT4
5Ponatinib 1110.0TEK, KDR
6Regorafenib1110.0TEK, KDR, FLT4
7su6668449.9VEGFA, KDR
8ptk787449.9VEGFA, KDR
9Vandetanib119.8TEK, VEGFA
10capecitabine44 49 1111.8TYMP, VEGFA
11taxane449.7VEGFA, TYMP, KDR
12erlotinib44 49 1111.7KDR, TYMP, VEGFA
13leucovorin44 49 1111.7VEGFA, TYMP, KDR
14azd 2171449.7FLT4, VEGFA, KDR
15zd6474449.7FLT4, VEGFA, KDR
16axitinib44 59 1111.7KDR, VEGFA, FLT4
17su5416449.7KDR, VEGFA, FLT4
18sunitinib44 49 1111.7KDR, VEGFA, FLT4
19gemcitabine44 49 1111.6VEGFA, TYMP, KDR
20cobalt chloride449.6VEGFA, SLC2A1
21sorafenib44 49 1111.6KDR, VEGFA, FLT4
22docetaxel44 49 59 1112.6KDR, TYMP, VEGFA
23vinorelbine44 1110.6TYMP, VEGFA
24cyclophosphamide44 49 1111.6F8, TYMP, KDR
25progestin449.4KDR, VEGFA, F8
26paclitaxel44 49 1111.3FLT4, VEGFA, TYMP, KDR
275fluorouracil449.2VEGFA, TYMP, KDR, SLC2A1
28xbai449.2SLC2A1, F8
29prostacyclin449.2F8, VEGFA, TYMP, KDR
30rapamycin449.1FLT4, VEGFA, KDR, SLC2A1
31matrigel449.1FLT4, VEGFA, TYMP, KDR, TEK
32thymidine44 2410.1TYMP, CD34, HBA2, KDR, TEK
33cisplatin44 49 59 1112.1SLC2A1, KDR, TYMP, VEGFA
34dexamethasone44 49 28 1111.9SLC2A1, KDR, VEGFA, F8
35ly294002448.9FLT4, VEGFA, TYMP, KDR, SLC2A1
36heparin44 28 11 2411.8SLC2A1, VEGFA, F8
37oxygen44 249.7TEK, SLC2A1, HBA1, HBA2, TYMP, FLT4
38cysteine448.7F8, TYMP, KDR, SLC2A1, TEK
39atp44 289.7F8, TYMP, HBA2, TAP1, SLC2A1
40paraffin448.1FLT4, VEGFA, TYMP, CD34, KDR, SLC2A1
41tyrosine447.2F8, FLT4, VEGFA, TYMP, CD34, HBA2
42vegf446.8TEK, F8, FLT4, PROX1, VEGFA, TYMP

GO Terms for genes affiliated with Capillary Hemangioma

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16Gene Ontology
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Cellular components related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.7TEK, KDR, CD34, PROM1, FLT4
2extracellular regionGO:0055767.9TEK, F8, FLT4, VEGFA, HBA2, KDR
3plasma membraneGO:0058867.1F8, FLT4, PROM1, CD34, TAP1, KDR

Biological processes related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:00194510.1FLT4, KDR
2negative regulation of endothelial cell apoptotic processGO:200035210.1KDR, TEK
3endothelium developmentGO:00315810.0KDR, CD34
4positive regulation of vasculogenesisGO:200121410.0CD34, KDR
5peptidyl-tyrosine phosphorylationGO:0181089.9TEK, KDR, FLT4
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.9FLT4, KDR, TEK
7positive regulation of intracellular protein kinase cascadeGO:0107409.9VEGFA, TEK
8positive regulation of positive chemotaxisGO:0509279.9VEGFA, KDR
9surfactant homeostasisGO:0431299.8VEGFA, KDR
10sprouting angiogenesisGO:0020409.8FLT4, TEK
11endothelial cell proliferationGO:0019359.8CD34, TEK
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TEK, KDR, FLT4
13positive regulation of protein kinase C signaling cascadeGO:0900379.8FLT4, VEGFA
14cell migration involved in sprouting angiogenesisGO:0020429.7KDR, VEGFA
15positive regulation of focal adhesion assemblyGO:0518949.7TEK, KDR, VEGFA
16cellular response to vascular endothelial growth factor stimulusGO:0359249.6KDR, VEGFA, FLT4
17vascular endothelial growth factor receptor signaling pathwayGO:0480109.6FLT4, VEGFA, KDR
18branching morphogenesis of an epithelial tubeGO:0487549.6KDR, VEGFA
19retina morphogenesis in camera-type eyeGO:0600429.6PROM1, PROX1
20lymphangiogenesisGO:0019469.5PROX1, FLT4
21protein autophosphorylationGO:0467779.5TEK, KDR, FLT4
22angiogenesisGO:0015259.4VEGFA, TYMP, KDR, TEK
23positive regulation of protein phosphorylationGO:0019349.3FLT4, VEGFA, KDR, TEK
24positive regulation of angiogenesisGO:0457669.1VEGFA, CD34, KDR, TEK
25negative regulation of apoptotic processGO:0430668.7FLT4, VEGFA, KDR, TEK
26positive regulation of endothelial cell migrationGO:0105958.5TEK, KDR, VEGFA, PROX1, FLT4
27positive regulation of endothelial cell proliferationGO:0019388.5FLT4, PROX1, VEGFA, KDR, TEK
28positive regulation of cell proliferationGO:0082848.5KDR, VEGFA, PROX1, FLT4

Molecular functions related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.9KDR, FLT4
2growth factor bindingGO:0198389.9KDR, FLT4
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6TEK, KDR, FLT4
4platelet-derived growth factor receptor bindingGO:0051619.3VEGFA, TYMP
5protein bindingGO:0055156.0VEGFA, PROX1, PROM1, FLT4, F8, HBA2

Products for genes affiliated with Capillary Hemangioma

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Sources for Capillary Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet