MCID: CPL006
MIFTS: 58

Capillary Hemangioma malady

Cancer diseases, Skin diseases, Cardiovascular diseases categories
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Summaries for Capillary Hemangioma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A capillary hemangioma (also known as an \"Infantile hemangioma,\" \"Strawberry hemangioma\", and... more...

MalaCards: Capillary Hemangioma, also known as strawberry nevus of skin, is related to hemangioma and pyogenic granuloma. An important gene associated with Capillary Hemangioma is TEK (TEK tyrosine kinase, endothelial), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and African trypanosomiasis. The compounds ponatinib and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and spinal cord, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Capillary Hemangioma

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8Disease Ontology, 10DISEASES, 62UMLS, 45Novoseek, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Cardiovascular diseases


Aliases & Descriptions:

capillary hemangioma 8 10
strawberry nevus of skin 8 62
cellular hemangioma of infancy 8
congenital vascular hamartoma 8
congenital vascular naevus 8
strawberry haemangioma 8
infantile hemangioma 8
hemangioma capillary 45
juvenile hemangioma 8
strawberry nevus 8


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Disease Ontology8 DOID:2725
NCIt40 C6645
MeSH35 D018324

Related Diseases for Capillary Hemangioma

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17GeneCards, 18GeneDecks
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Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.6TEK, VEGFA, HBA1, HBA2, KDR, CD34
2pyogenic granuloma31.0SLC2A1, CD34, TEK
3meningioma30.1SLC2A1, CD34
4hemangioblastoma30.0SLC2A1, KDR, VEGFA
5kaposi's sarcoma30.0TEK, VEGFA, KDR, CD34
6retinitis10.8
7von hippel-lindau disease10.6
8breast capillary hemangioma10.3
9retinal detachment10.3
10phace syndrome10.3
11endotheliitis10.3
12klippel-trenaunay syndrome10.2
13astigmatism10.2
14cavernous hemangioma10.2
15cervicitis10.2
16mediastinitis10.2
17renal cell carcinoma10.2
18tufted angioma10.2
19hemangioma, capillary infantile10.2
20hemangioma, capillary infantile, somatic10.2
21capillary malformations, congenital, 1, somatic, mosaic10.2
22melorheostosis with osteopoikilosis10.2
23dental caries10.2
24giant infantile hemangioma10.2
25hemoglobin h disease, nondeletional10.1HBA1, HBA2
26epithelioid sarcoma10.1HBA2, HBA1
27kidney cancer10.1VEGFA
28cardiac tamponade10.1
29klinefelter's syndrome10.1
30rubinstein-taybi syndrome10.1
31williams-beuren syndrome10.1
32gastric antral vascular ectasia10.1
33angiodysplasia10.1
34exophthalmos10.1
35hyperandrogenism10.1
36patau syndrome10.1
37angioma serpiginosum10.1
38beckwith-wiedemann syndrome10.1
39syringocystadenoma papilliferum10.1
40roberts syndrome10.1
41ollier disease10.1
42incontinentia pigmenti achromians10.1
43cryptorchidism10.1
44radiculopathy10.1
45tuberous sclerosis10.1
46wolf-hirschhorn syndrome10.1
47branchiooculofacial syndrome10.1
48bannayan-riley-ruvalcaba syndrome10.1
49poems syndrome10.1
50otospondylomegaepiphyseal dysplasia10.1

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to capillary hemangioma

Symptoms for Capillary Hemangioma

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Drugs & Therapeutics for Capillary Hemangioma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Capillary Hemangioma

Search NIH Clinical Center for Capillary Hemangioma

Genetic Tests for Capillary Hemangioma

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Anatomical Context for Capillary Hemangioma

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33MalaCards
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MalaCards organs/tissues related to Capillary Hemangioma:

33
Skin, Lung, Spinal cord, Testis, Bone, Liver, Retina, Endothelial, Trachea, Kidney, Cervix, Tongue, Spleen, Prostate, Brain, Breast, Salivary gland, Heart, Small intestine

Animal Models for Capillary Hemangioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Capillary Hemangioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3KDR, HBA2, VEGFA, TEK
2MP:00107717.6VEGFA, HBA2, KDR, TAP1, CD34
3MP:00053977.4TEK, VEGFA, HBA2, KDR, TAP1, CD34
4MP:00036317.1TEK, TYMP, VEGFA, KDR, TAP1, SLC2A1
5MP:00107687.1TEK, VEGFA, HBA1, HBA2, KDR, TAP1
6MP:00053846.9SLC2A1, TEK, TYMP, VEGFA, HBA2, KDR
7MP:00053766.9TEK, TYMP, VEGFA, HBA2, KDR, CD34

Publications for Capillary Hemangioma

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52PubMed
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Articles related to Capillary Hemangioma:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Nasal lobular capillary hemangioma. (24228209)
2013
2
A suspicious breast lesion detected by dynamic contrast-enhanced MRI and pathologically confirmed as capillary hemangioma: a case report and literature review. (24265560)
2013
3
Strawberries on the brain-intracranial capillary hemangioma: two case reports and systematic literature review in children and adults. (23247022)
2013
4
Intravenous Lobular Capillary Hemangioma Occurring after Needle Insertion during Routine Health Checkup. (23641295)
2013
5
Purely Cutaneous Rosai-Dorfman disease (CRDD) co-existed with capillary hemangioma successfully treated with intralesional corticosteroid. (24164002)
2013
6
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
7
Capillary hemangioma treatment. (22944499)
2012
8
Rapid regrowth of a capillary hemangioma of the thoracic spinal cord. (23006883)
2012
9
Capillary hemangioma masquerading as a renal artery pseudoaneurysm. (22342407)
2012
10
Aortic coarctation in the presence of capillary hemangioma. (21764546)
2011
11
Incidentally discovered capillary hemangioma of the prostate. (22018156)
2011
12
Capillary hemangioma in a rib presenting as large pleural effusion. (21440110)
2011
13
Reduction in astigmatism using propranolol as first-line therapy for periocular capillary hemangioma. (20970771)
2011
14
Simultaneous massive low gastrointestinal bleeding and hemoperitoneum caused by a capillary hemangioma in ileocecal valve. (21302118)
2011
15
Lobular capillary hemangioma in the soft tissue of the finger: sonographic findings. (20428860)
2010
16
Intravenous lobular capillary hemangioma. (20494549)
2010
17
Jejunal capillary hemangioma treated by using double-balloon endoscopy (with video). (20546731)
2010
18
Pyogenic granuloma: lobular capillary hemangioma in the upper lip of a 24-month-old child: case report. (19941768)
2009
19
A rare vascular tumor of the external auditory canal: the capillary hemangioma. (19860637)
2009
20
Intradural capillary hemangioma of the cauda equina. (18663441)
2008
21
Congenital enormous high flow capillary hemangioma of forearm. (18309319)
2008
22
A case of cerebellar capillary hemangioma with multiple cysts. (18552520)
2008
23
Optic disc hemangioblastoma (capillary hemangioma) with ipsilateral oculodermal melanocytosis. (18661277)
2008
24
Ovarian capillary hemangioma presenting as pseudo-Meigs' syndrome: a case report. (17478373)
2007
25
Unusual location of a capillary hemangioma: inguinal location. (17576501)
2007
26
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
27
Capillary hemangioma of the tympanic membrane. (16137537)
2005
28
Retinal capillary hemangioma in von Hippel-Lindau disease. (16049535)
2005
29
Capillary hemangioma of the endometrium: a case report and review of the literature. (16196525)
2005
30
Lobular capillary hemangioma of the nasal cavity. (16089224)
2005
31
Thoracic intradural extramedullary capillary hemangioma. (15313728)
2004
32
Childhood capillary hemangioma presenting as infantile perianal protrusion. (14657638)
2003
33
Capillary hemangioma of the calvaria. (12845203)
2003
34
Lobular capillary hemangioma of the oral mucosa: clinicopathological study of 43 cases with a special reference to immunohistochemical characterization of the vascular elements. (12558863)
2003
35
Treatment of retinal capillary hemangioma. (12359597)
2002
36
Spinal intradural extramedullary capillary hemangioma: MR imaging findings. (11290503)
2001
37
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
38
Ruthenium-106 brachytherapy for peripheral retinal capillary hemangioma. (9709747)
1998
39
Neurologic toxicity associated with interferon alfa treatment of capillary hemangioma. (10532761)
1997
40
Capillary hemangioma--report of a case. (9522754)
1996
41
Capillary hemangioma of the vocal cord. (7628325)
1995
42
Nasal glioma masquerading as a capillary hemangioma. (8323905)
1993
43
Capillary hemangioma of the optic disc associated with a total retinal detachment. (8259247)
1993
44
Treatment of a massive orbital-capillary hemangioma with interferon alfa-2b: short-term results. (1417530)
1992
45
Capillary hemangioma in the cauda equina: neuroradiological findings. (1749484)
1991
46
Pathologic quiz case 2. Intramuscular capillary hemangioma. (3790291)
1987
47
Intraosseous capillary hemangioma of the frontal bone. (3591881)
1987
48
Intralesional corticosteroid injection for capillary hemangioma of the eyelid. (3765021)
1986
49
Ossifying capillary hemangioma of the maxillary and ethmoid sinuses - a case report. (6801269)
1981
50
Ultrastructural study of hemangiomas. 1. Capillary hemangioma of the skin. (7234415)
1981

Variations for Capillary Hemangioma

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Expression for genes affiliated with Capillary Hemangioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for genes affiliated with Capillary Hemangioma

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Sources:
50PathCards, 55Reactome, 30KEGG, 54R&D Systems, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters, 51PharmGKB, 57SinoBiological
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Pathways related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HBA2, HBA1
29.6HBA2, HBA1
39.6HBA1, HBA2
4
Show member pathways
9.6HBA1, HBA2
59.5KDR, TEK
69.1SLC2A1, VEGFA
79.1VEGFA, SLC2A1
89.1TEK, TYMP, KDR
99.0KDR, VEGFA
109.0KDR, VEGFA
11
Show member pathways
9.0KDR, VEGFA
12
Show member pathways
VEGFR1 specific signals38
9.0KDR, VEGFA
13
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.0VEGFA, KDR
14
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.0KDR, VEGFA
159.0VEGFA, KDR
169.0KDR, VEGFA
17
Show member pathways
9.0VEGFA, KDR
189.0KDR, VEGFA
198.8SLC2A1, VEGFA, TEK
20
Show member pathways
8.7TEK, VEGFA, KDR
218.7TEK, VEGFA, KDR
22
Show member pathways
Angiogenesis38
8.7KDR, VEGFA, TEK
238.5SLC2A1, KDR, VEGFA

Compounds for genes affiliated with Capillary Hemangioma

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51PharmGKB, 11DrugBank, 45Novoseek, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1ponatinib51 1110.9KDR, TEK
2capecitabine45 51 1111.6TYMP, VEGFA
3vinorelbine45 51 1111.6VEGFA, TYMP
4fluorouracil51 1110.5VEGFA, TYMP
5cobalt chloride459.5SLC2A1, VEGFA
6azd 2171459.5KDR, VEGFA
7ptk787459.4VEGFA, KDR
8su6668459.4VEGFA, KDR
9zd6474459.4VEGFA, KDR
10ifn-alpha459.4TAP1, TYMP
11axitinib61 45 1111.4KDR, VEGFA
12su5416459.4VEGFA, KDR
13sunitinib45 51 1111.4VEGFA, KDR
14marimastat45 61 1111.3KDR, VEGFA
15infliximab45 51 1111.3VEGFA, TEK
16cetuximab45 51 1111.3VEGFA, KDR
17vandetanib51 1110.2KDR, VEGFA, TEK
18regorafenib51 1110.1TEK, VEGFA, KDR
19agar459.1SLC2A1, CD34, KDR
20oxaliplatin45 51 1111.1VEGFA, TYMP
21wortmannin459.1TYMP, KDR, SLC2A1
22sorafenib45 51 1111.1VEGFA, KDR
23taxane459.1TYMP, VEGFA, KDR
24erlotinib45 51 1111.1KDR, VEGFA, TYMP
25leucovorin45 51 1111.0TYMP, VEGFA, KDR
26trastuzumab45 51 1111.0KDR, VEGFA
27gemcitabine45 51 1111.0KDR, VEGFA, TYMP
28docetaxel45 51 61 1112.0KDR, VEGFA, TYMP
29atp45 2910.0TYMP, HBA2, TAP1, SLC2A1
30cyclophosphamide45 51 1111.0KDR, VEGFA, TYMP
31prostacyclin459.0KDR, VEGFA, TYMP
32tamoxifen45 51 29 1111.9KDR, VEGFA, TYMP
33paclitaxel45 51 1110.9KDR, VEGFA, TYMP
34egcg458.9VEGFA, KDR, SLC2A1
35actinomycin d458.9TYMP, VEGFA, SLC2A1
36cysteine458.8TEK, TYMP, KDR, SLC2A1
37oxygen45 249.8TEK, TYMP, HBA1, HBA2, SLC2A1
38doxorubicin45 51 1110.8KDR, VEGFA, TYMP
39rapamycin458.8SLC2A1, KDR, VEGFA
40matrigel458.7TEK, TYMP, VEGFA, KDR
41genistein45 29 61 3 24 1113.6SLC2A1, KDR, VEGFA
42thymidine45 249.6TEK, TYMP, HBA2, KDR, CD34
435fluorouracil458.5TYMP, VEGFA, KDR, SLC2A1
44ly294002458.5SLC2A1, KDR, VEGFA, TYMP
45cisplatin45 51 61 1111.5TYMP, VEGFA, KDR, SLC2A1
46estrogen458.0SLC2A1, CD34, KDR, VEGFA, TYMP
47paraffin457.7SLC2A1, CD34, KDR, VEGFA, TYMP, TEK
48vegf457.7TEK, TYMP, VEGFA, KDR, CD34, SLC2A1
49tyrosine457.2TEK, TYMP, VEGFA, HBA2, KDR, CD34

GO Terms for genes affiliated with Capillary Hemangioma

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16Gene Ontology
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Cellular components related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:0099259.6CD34, TEK

Biological processes related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1endothelial cell proliferationGO:0019359.9CD34, TEK
2negative regulation of endothelial cell apoptotic processGO:20003529.8KDR, TEK
3endothelium developmentGO:0031589.7CD34, KDR
4positive regulation of intracellular signal transductionGO:19025339.7VEGFA, TEK
5positive regulation of vasculogenesisGO:20012149.6CD34, KDR
6positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6KDR, TEK
7surfactant homeostasisGO:0431299.3KDR, VEGFA
8positive regulation of peptidyl-serine phosphorylationGO:0331389.3VEGFA, TEK
9positive regulation of positive chemotaxisGO:0509279.3VEGFA, KDR
10cell migration involved in sprouting angiogenesisGO:0020429.3KDR, VEGFA
11cellular response to vascular endothelial growth factor stimulusGO:0359249.3VEGFA, KDR
12vascular endothelial growth factor receptor signaling pathwayGO:0480109.3KDR, VEGFA
13transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.2KDR, TEK
14branching morphogenesis of an epithelial tubeGO:0487549.2KDR, VEGFA
15positive regulation of mesenchymal cell proliferationGO:0020539.2KDR, VEGFA
16cell maturationGO:0484699.2VEGFA, KDR
17ovarian follicle developmentGO:0015419.1KDR, VEGFA
18positive regulation of focal adhesion assemblyGO:0518949.1KDR, VEGFA, TEK
19positive regulation of endothelial cell migrationGO:0105959.1TEK, VEGFA, KDR
20positive regulation of endothelial cell proliferationGO:0019389.1TEK, VEGFA, KDR
21positive regulation of protein phosphorylationGO:0019349.0TEK, VEGFA, KDR
22vasculogenesisGO:0015708.9VEGFA, KDR
23negative regulation of apoptotic processGO:0430668.7KDR, VEGFA, TEK
24angiogenesisGO:0015258.7KDR, VEGFA, TYMP, TEK
25positive regulation of angiogenesisGO:0457668.6CD34, KDR, VEGFA, TEK

Molecular functions related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.5KDR, TEK
2growth factor bindingGO:0198389.2KDR, TEK
3platelet-derived growth factor receptor bindingGO:0051619.1VEGFA, TYMP

Products for genes affiliated with Capillary Hemangioma

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Sources for Capillary Hemangioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet