MCID: CPL006
MIFTS: 59

Capillary Hemangioma malady

Genetic diseases, Skin diseases, Cardiovascular diseases, Eye diseases, Fetal diseases, Rare diseases categories

Summaries for Capillary Hemangioma

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Wikipedia:65 A capillary hemangioma (also known as an \"Infantile hemangioma,\" \"Strawberry hemangioma\", and... more...

MalaCards based summary: Capillary Hemangioma, also known as congenital vascular hamartoma, is related to hemangioma and pyogenic granuloma. An important gene associated with Capillary Hemangioma is TEK (TEK tyrosine kinase, endothelial), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and African trypanosomiasis. The compounds ponatinib and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and lung, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Capillary Hemangioma

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Sources:
10Disease Ontology, 12DISEASES, 62UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Capillary Hemangioma, Aliases & Descriptions:

Name: Capillary Hemangioma 10 12
Congenital Vascular Hamartoma 10 62
Congenital Vascular Naevus 10 62
Strawberry Nevus of Skin 10 62
Strawberry Haemangioma 10 62
 
Cellular Hemangioma of Infancy 10
Infantile Hemangioma 10
Hemangioma Capillary 45
Juvenile Hemangioma 10
Strawberry Nevus 10


Classifications:



External Ids:

Disease Ontology10 DOID:2725
MeSH35 D018324
NCIt40 C6645

Related Diseases for Capillary Hemangioma

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Diseases in the Capillary Hemangioma family:

Hemangioma, Capillary Infantile Familial Capillary Hemangioma

Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.8TEK, VEGFA, HBA1, HBA2, KDR, CD34
2pyogenic granuloma31.1SLC2A1, CD34, TEK
3renal cell carcinoma30.5VEGFA
4hemangioblastoma30.1SLC2A1, KDR, VEGFA
5congenital heart disease30.0VEGFA, HBA1, HBA2
6retinitis10.9
7retinal detachment10.4
8breast capillary hemangioma10.3
9phace syndrome10.3
10endotheliitis10.3
11hemangioma, capillary infantile10.2
12roberts syndrome10.2
13smith-lemli-opitz syndrome10.2
14craniolenticulosutural dysplasia10.2
15rubinstein-taybi syndrome10.2
16capillary malformations, congenital, 1, somatic, mosaic10.2
17astigmatism10.2
18cavernous hemangioma10.2
19cervicitis10.2
20mediastinitis10.2
21tufted angioma10.2
22familial capillary hemangioma10.2
23myofibroma10.2
24dental caries10.2
25thrombocytopenia-absent radius syndrome10.1
26gapo syndrome10.1
27asthma10.1
28multiple pterygium syndrome, lethal type10.1
29perlman syndrome10.1
30von hippel-lindau syndrome10.1
31robinow syndrome, autosomal dominant10.1
32c syndrome10.1
33kahrizi syndrome10.1
34parkes weber syndrome10.1
35capillary malformation-arteriovenous malformation10.1
36beckwith-wiedemann syndrome10.1
37branchiooculofacial syndrome10.1
38otospondylomegaepiphyseal dysplasia10.1
39pallister-hall syndrome10.1
40williams-beuren syndrome10.1
41sc phocomelia syndrome10.1
42klippel-trenaunay-weber syndrome10.1
43ritscher-schinzel syndrome10.1
44baller-gerold syndrome10.1
45robinow syndrome, autosomal recessive10.1
46bannayan-riley-ruvalcaba syndrome10.1
47omodysplasia 110.1
48congenital disorder of glycosylation, type iia10.1
49bohring-opitz syndrome10.1
50osseous heteroplasia, progressive10.1

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to capillary hemangioma

Symptoms for Capillary Hemangioma

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Drugs & Therapeutics for Capillary Hemangioma

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Drug clinical trials:

Search ClinicalTrials for Capillary Hemangioma

Search NIH Clinical Center for Capillary Hemangioma

Genetic Tests for Capillary Hemangioma

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Anatomical Context for Capillary Hemangioma

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MalaCards organs/tissues related to Capillary Hemangioma:

33
Skin, Spinal cord, Lung, Bone, Retina, Testis, Liver, Endothelial, Trachea, Spleen, Kidney, Cervix, Brain, Heart, Small intestine, Salivary gland, Breast, Prostate, Tongue

Animal Models for Capillary Hemangioma or affiliated genes

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MGI Mouse Phenotypes related to Capillary Hemangioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3KDR, HBA2, VEGFA, TEK
2MP:00107717.6VEGFA, HBA2, KDR, TAP1, CD34
3MP:00053977.4TEK, VEGFA, HBA2, KDR, TAP1, CD34
4MP:00036317.1TEK, TYMP, VEGFA, KDR, TAP1, SLC2A1
5MP:00107687.1TEK, VEGFA, HBA1, HBA2, KDR, TAP1
6MP:00053846.9SLC2A1, TEK, TYMP, VEGFA, HBA2, KDR
7MP:00053766.9TEK, TYMP, VEGFA, HBA2, KDR, CD34

Publications for Capillary Hemangioma

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Articles related to Capillary Hemangioma:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Lobular capillary hemangioma of the trachea. (25644803)
2015
2
Photodynamic therapy for juxtapapillary retinal capillary hemangioma. (24716060)
2014
3
Intradural extramedullary capillary hemangioma in the upper thoracic spine: a review of the literature. (25045565)
2014
4
Management of a bulky capillary hemangioma in the parapharyngeal space with minimally invasive surgery. (24481164)
2014
5
Nasal lobular capillary hemangioma. (24228209)
2013
6
A suspicious breast lesion detected by dynamic contrast-enhanced MRI and pathologically confirmed as capillary hemangioma: a case report and literature review. (24265560)
2013
7
Strawberries on the brain-intracranial capillary hemangioma: two case reports and systematic literature review in children and adults. (23247022)
2013
8
Intravenous lobular capillary hemangioma occurring in the cephalic vein of a 39-year-old adult. (24151094)
2013
9
Intraneural capillary hemangioma: a rare cause of proximal median neuropathy. (24441340)
2013
10
Intravenous Lobular Capillary Hemangioma Occurring after Needle Insertion during Routine Health Checkup. (23641295)
2013
11
Purely Cutaneous Rosai-Dorfman disease (CRDD) co-existed with capillary hemangioma successfully treated with intralesional corticosteroid. (24164002)
2013
12
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
13
Capillary hemangioma treatment. (22944499)
2012
14
Rapid regrowth of a capillary hemangioma of the thoracic spinal cord. (23006883)
2012
15
Aortic coarctation in the presence of capillary hemangioma. (21764546)
2011
16
Incidentally discovered capillary hemangioma of the prostate. (22018156)
2011
17
Capillary hemangioma in a rib presenting as large pleural effusion. (21440110)
2011
18
Reduction in astigmatism using propranolol as first-line therapy for periocular capillary hemangioma. (20970771)
2011
19
Lobular capillary hemangioma in the soft tissue of the finger: sonographic findings. (20428860)
2010
20
Intravenous lobular capillary hemangioma. (20494549)
2010
21
Jejunal capillary hemangioma treated by using double-balloon endoscopy (with video). (20546731)
2010
22
Pyogenic granuloma: lobular capillary hemangioma in the upper lip of a 24-month-old child: case report. (19941768)
2009
23
A rare vascular tumor of the external auditory canal: the capillary hemangioma. (19860637)
2009
24
Intradural capillary hemangioma of the cauda equina. (18663441)
2008
25
Congenital enormous high flow capillary hemangioma of forearm. (18309319)
2008
26
Ovarian capillary hemangioma presenting as pseudo-Meigs' syndrome: a case report. (17478373)
2007
27
Unusual location of a capillary hemangioma: inguinal location. (17576501)
2007
28
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
29
Capillary hemangioma of the tympanic membrane. (16137537)
2005
30
Retinal capillary hemangioma in von Hippel-Lindau disease. (16049535)
2005
31
Capillary hemangioma of the endometrium: a case report and review of the literature. (16196525)
2005
32
Lobular capillary hemangioma of the nasal cavity. (16089224)
2005
33
Thoracic intradural extramedullary capillary hemangioma. (15313728)
2004
34
Childhood capillary hemangioma presenting as infantile perianal protrusion. (14657638)
2003
35
Capillary hemangioma of the calvaria. (12845203)
2003
36
Lobular capillary hemangioma of the oral mucosa: clinicopathological study of 43 cases with a special reference to immunohistochemical characterization of the vascular elements. (12558863)
2003
37
Treatment of retinal capillary hemangioma. (12359597)
2002
38
Spinal intradural extramedullary capillary hemangioma: MR imaging findings. (11290503)
2001
39
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
40
Neurologic toxicity associated with interferon alfa treatment of capillary hemangioma. (10532761)
1997
41
Capillary hemangioma--report of a case. (9522754)
1996
42
Capillary hemangioma of the vocal cord. (7628325)
1995
43
Nasal glioma masquerading as a capillary hemangioma. (8323905)
1993
44
Capillary hemangioma of the optic disc associated with a total retinal detachment. (8259247)
1993
45
Treatment of a massive orbital-capillary hemangioma with interferon alfa-2b: short-term results. (1417530)
1992
46
Capillary hemangioma in the cauda equina: neuroradiological findings. (1749484)
1991
47
Treatment of a capillary hemangioma with the flashlamp pumped-dye laser. (2298954)
1990
48
Pathologic quiz case 2. Intramuscular capillary hemangioma. (3790291)
1987
49
Intraosseous capillary hemangioma of the frontal bone. (3591881)
1987
50
Intralesional corticosteroid injection for capillary hemangioma of the eyelid. (3765021)
1986

Variations for Capillary Hemangioma

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Expression for genes affiliated with Capillary Hemangioma

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Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for genes affiliated with Capillary Hemangioma

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Pathways related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HBA2, HBA1
29.6HBA2, HBA1
39.6HBA1, HBA2
4
Show member pathways
9.6HBA1, HBA2
59.5KDR, TEK
69.1SLC2A1, VEGFA
79.1VEGFA, SLC2A1
89.1TEK, TYMP, KDR
99.0KDR, VEGFA
109.0KDR, VEGFA
11
Show member pathways
9.0KDR, VEGFA
12
Show member pathways
VEGFR1 specific signals38
9.0KDR, VEGFA
13
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.0VEGFA, KDR
14
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.0KDR, VEGFA
159.0VEGFA, KDR
169.0KDR, VEGFA
17
Show member pathways
9.0VEGFA, KDR
189.0KDR, VEGFA
198.8SLC2A1, VEGFA, TEK
20
Show member pathways
8.7TEK, VEGFA, KDR
218.7TEK, VEGFA, KDR
22
Show member pathways
Angiogenesis38
8.7KDR, VEGFA, TEK
238.5SLC2A1, KDR, VEGFA

Compounds for genes affiliated with Capillary Hemangioma

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Compounds related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1ponatinib51 1310.9KDR, TEK
2capecitabine45 51 1311.6TYMP, VEGFA
3vinorelbine45 51 1311.6VEGFA, TYMP
4fluorouracil51 1310.5VEGFA, TYMP
5cobalt chloride459.5SLC2A1, VEGFA
6azd 2171459.5KDR, VEGFA
7ptk787459.4VEGFA, KDR
8su6668459.4VEGFA, KDR
9zd6474459.4VEGFA, KDR
10ifn-alpha459.4TAP1, TYMP
11axitinib61 45 1311.4KDR, VEGFA
12su5416459.4VEGFA, KDR
13sunitinib45 51 1311.4VEGFA, KDR
14marimastat45 61 1311.3KDR, VEGFA
15infliximab45 51 1311.3VEGFA, TEK
16cetuximab45 51 1311.3VEGFA, KDR
17vandetanib51 1310.2KDR, VEGFA, TEK
18regorafenib51 1310.1TEK, VEGFA, KDR
19agar459.1SLC2A1, CD34, KDR
20oxaliplatin45 51 1311.1VEGFA, TYMP
21wortmannin459.1TYMP, KDR, SLC2A1
22sorafenib45 51 1311.1VEGFA, KDR
23taxane459.1TYMP, VEGFA, KDR
24erlotinib45 51 1311.1KDR, VEGFA, TYMP
25leucovorin45 51 1311.0TYMP, VEGFA, KDR
26trastuzumab45 51 1311.0KDR, VEGFA
27gemcitabine45 51 1311.0KDR, VEGFA, TYMP
28docetaxel45 51 61 1312.0KDR, VEGFA, TYMP
29atp45 3010.0TYMP, HBA2, TAP1, SLC2A1
30cyclophosphamide45 51 1311.0KDR, VEGFA, TYMP
31prostacyclin459.0KDR, VEGFA, TYMP
32tamoxifen45 51 30 1311.9KDR, VEGFA, TYMP
33paclitaxel45 51 1310.9KDR, VEGFA, TYMP
34egcg458.9VEGFA, KDR, SLC2A1
35actinomycin d458.9TYMP, VEGFA, SLC2A1
36cysteine458.8TEK, TYMP, KDR, SLC2A1
37oxygen45 269.8TEK, TYMP, HBA1, HBA2, SLC2A1
38doxorubicin45 51 1310.8KDR, VEGFA, TYMP
39rapamycin458.8SLC2A1, KDR, VEGFA
40matrigel458.7TEK, TYMP, VEGFA, KDR
41genistein45 30 61 3 26 1313.6SLC2A1, KDR, VEGFA
42thymidine45 269.6TEK, TYMP, HBA2, KDR, CD34
435fluorouracil458.5TYMP, VEGFA, KDR, SLC2A1
44ly294002458.5SLC2A1, KDR, VEGFA, TYMP
45cisplatin45 51 61 1311.5TYMP, VEGFA, KDR, SLC2A1
46estrogen458.0SLC2A1, CD34, KDR, VEGFA, TYMP
47paraffin457.7SLC2A1, CD34, KDR, VEGFA, TYMP, TEK
48vegf457.7TEK, TYMP, VEGFA, KDR, CD34, SLC2A1
49tyrosine457.2TEK, TYMP, VEGFA, HBA2, KDR, CD34

GO Terms for genes affiliated with Capillary Hemangioma

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Cellular components related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:00099259.6CD34, TEK

Biological processes related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1endothelial cell proliferationGO:00019359.9CD34, TEK
2negative regulation of endothelial cell apoptotic processGO:020003529.8KDR, TEK
3endothelium developmentGO:00031589.7CD34, KDR
4positive regulation of intracellular signal transductionGO:019025339.7VEGFA, TEK
5positive regulation of vasculogenesisGO:020012149.6CD34, KDR
6positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6KDR, TEK
7surfactant homeostasisGO:00431299.3KDR, VEGFA
8positive regulation of peptidyl-serine phosphorylationGO:00331389.3VEGFA, TEK
9positive regulation of positive chemotaxisGO:00509279.3VEGFA, KDR
10cell migration involved in sprouting angiogenesisGO:00020429.3KDR, VEGFA
11cellular response to vascular endothelial growth factor stimulusGO:00359249.3VEGFA, KDR
12vascular endothelial growth factor receptor signaling pathwayGO:00480109.3KDR, VEGFA
13transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.2KDR, TEK
14branching morphogenesis of an epithelial tubeGO:00487549.2KDR, VEGFA
15positive regulation of mesenchymal cell proliferationGO:00020539.2KDR, VEGFA
16cell maturationGO:00484699.2VEGFA, KDR
17ovarian follicle developmentGO:00015419.1KDR, VEGFA
18positive regulation of focal adhesion assemblyGO:00518949.1KDR, VEGFA, TEK
19positive regulation of endothelial cell migrationGO:00105959.1TEK, VEGFA, KDR
20positive regulation of endothelial cell proliferationGO:00019389.1TEK, VEGFA, KDR
21positive regulation of protein phosphorylationGO:00019349.0TEK, VEGFA, KDR
22vasculogenesisGO:00015708.9VEGFA, KDR
23negative regulation of apoptotic processGO:00430668.7KDR, VEGFA, TEK
24angiogenesisGO:00015258.7KDR, VEGFA, TYMP, TEK
25positive regulation of angiogenesisGO:00457668.6CD34, KDR, VEGFA, TEK

Molecular functions related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.5KDR, TEK
2growth factor bindingGO:00198389.2KDR, TEK
3platelet-derived growth factor receptor bindingGO:00051619.1VEGFA, TYMP

Products for genes affiliated with Capillary Hemangioma

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Sources for Capillary Hemangioma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet