MCID: CPL006
MIFTS: 57

Capillary Hemangioma malady

Skin diseases, Cardiovascular diseases categories

Summaries for Capillary Hemangioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A capillary hemangioma (also known as an \"Infantile hemangioma,\" \"Strawberry hemangioma\", and... more...

MalaCards: Capillary Hemangioma, also known as strawberry nevus of skin, is related to hemangioma and retinal disease. An important gene associated with Capillary Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are Tyrosine Kinases / Adaptors and Akt Signaling Pathway . The compounds estrogen and vegfc have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and spinal cord, and related mouse phenotypes are nervous system and integument.

Aliases & Classifications for Capillary Hemangioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Cardiovascular diseases


Aliases & Descriptions:

capillary hemangioma 8 10
strawberry nevus of skin 8 60
cellular hemangioma of infancy 8
congenital vascular hamartoma 8
congenital vascular naevus 8
strawberry haemangioma 8
infantile hemangioma 8
hemangioma capillary 44
juvenile hemangioma 8
strawberry nevus 8


External Ids:

Disease Ontology8 DOID:2725
MeSH34 D018324
NCIt39 C6645

Related Diseases for Capillary Hemangioma

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17GeneCards, 18GeneDecks
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Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.8TEK, SLC2A1, KDR, HBA1, HBA2, CD34
2retinal disease30.8F8, VEGFA, KDR, SLC2A1, TEK
3hemangioma, capillary infantile30.2FLT4, KDR
4hemangioma, capillary infantile, somatic30.2FLT4, KDR
5klippel-trenaunay syndrome30.2FLT4
6pyogenic granuloma30.2FLT4, CD34, SLC2A1, TEK
7hepatitis30.0TYMP, F8
8hemangioblastoma30.0VEGFA, KDR, SLC2A1
9renal clear cell carcinoma30.0SLC2A1, KDR, VEGFA
10meningioma30.0CD34, SLC2A1
11kaposi's sarcoma30.0FLT4, VEGFA, CD34, KDR, TEK
12retinopathy of prematurity30.0VEGFA
13retinoblastoma29.9PROM1, FLT4
14retinitis10.8
15capillary disease10.6
16von hippel-lindau disease10.6
17hemangioma of orbit10.5
18cavernous hemangioma10.5
19acquired hemangioma10.4
20hemangioma of lung10.4
21hemangioma of liver10.3
22breast capillary hemangioma10.3
23giant hemangioma10.3
24central nervous system hemangioma10.3
25retinal detachment10.3
26skin hemangioma10.3
27intramuscular hemangioma10.2
28astigmatism10.2
29cervicitis10.2
30mediastinitis10.2
31renal cell carcinoma10.2
32sclerosing hemangioma10.2
33capillary malformations, congenital, 1, somatic, mosaic10.2
34melorheostosis with osteopoikilosis10.2
35dental caries10.1
36giant infantile hemangioma10.1
37hemangioma of subcutaneous tissue10.0
38thrombocytopenia-absent radius syndrome10.0
39smith-lemli-opitz syndrome10.0
40cardiac tamponade10.0
41williams-beuren syndrome10.0
42rubinstein-taybi syndrome10.0
43gastric hemangioma10.0
44klinefelter's syndrome10.0
45hemangioma of spleen10.0
46bannayan-riley-ruvalcaba syndrome10.0
47nasal cavity inverting papilloma10.0
48incontinentia pigmenti achromians10.0
49cryptorchidism10.0
50radiculopathy10.0

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to capillary hemangioma

Clinical Features for Capillary Hemangioma

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Drugs & Therapeutics for Capillary Hemangioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Capillary Hemangioma

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Anatomical Context for Capillary Hemangioma

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32MalaCards
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MalaCards organs/tissues related to Capillary Hemangioma:

32
Skin, Lung, Spinal cord, Endothelial, Liver, Testis, Bone, Retina, Trachea, Kidney, Lymph node, Cervix, Tongue, Spleen, Prostate, Brain, Breast, Salivary gland, Heart, Small intestine

Animal Models for Capillary Hemangioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Capillary Hemangioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.6PROX1, TYMP, TAP1, SLC2A1
2MP:00107718.5VEGFA, CD34, TAP1, KDR
3MP:00030128.4SLC2A1, KDR, VEGFA, PROM1, FLT4
4MP:00053768.3F8, PROX1, CD34, HBA2
5MP:00053876.9F8, FLT4, PROX1, VEGFA, TYMP, CD34
6MP:00053976.9F8, PROX1, VEGFA, CD34, HBA2, TAP1
7MP:00053786.8FLT4, PROM1, PROX1, VEGFA, HBA2, KDR
8MP:00053846.3TYMP, VEGFA, PROX1, PROM1, CD34, HBA2
9MP:00107686.0TEK, F8, FLT4, PROM1, PROX1, VEGFA

Publications for Capillary Hemangioma

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50PubMed
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Articles related to Capillary Hemangioma:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Nasal lobular capillary hemangioma. (24228209)
2013
2
Strawberries on the brain-intracranial capillary hemangioma: two case reports and systematic literature review in children and adults. (23247022)
2013
3
Intravenous lobular capillary hemangioma occurring in the cephalic vein of a 39-year-old adult. (24151094)
2013
4
Sinonasal lobular capillary hemangioma: a clinicopathologic study of 34 cases characterizing potential for local recurrence. (23184353)
2013
5
Primary Surgical Excision for Pediatric Orbital Capillary Hemangioma. (24117453)
2013
6
A Resected Case of Solitary Pulmonary Capillary Hemangioma Showing Pure Ground Glass Opacity. (23518632)
2013
7
Ultrasonography in the management of a recurrent and eruptive lobular capillary hemangioma and resolution with intense pulsed light. (24195100)
2013
8
Capillary hemangioma masquerading as a renal artery pseudoaneurysm. (22342407)
2012
9
Pediatric nasal lobular capillary hemangioma. (22919398)
2012
10
Capillary hemangioma of the esophagus in a patient with systemic sclerosis and gastric antral vascular ectasia. (22817793)
2012
11
Antenatal ultrasonographic features of fetal capillary hemangioma in the posterior fossa. (21040213)
2011
12
Echographic evidence of regression of a periocular infantile capillary hemangioma treated with systemic propranolol. (21323190)
2011
13
Capillary hemangioma of the cervical intervertebral disc. (20490869)
2011
14
Jejunal capillary hemangioma treated by using double-balloon endoscopy (with video). (20546731)
2010
15
Combined capillary hemangioma and angiodysplasia of the ileum: an unusual cause of obscure gastrointestinal bleeding with preoperative localization by double-balloon endoscopy. (20385367)
2010
16
Optic disc hemangioblastoma (capillary hemangioma) with ipsilateral oculodermal melanocytosis. (18661277)
2008
17
Spinal capillary hemangioma in infants: report of two cases and review of the literature. (17337925)
2007
18
Large left ventricular capillary hemangioma with cavernous areas. (17420812)
2007
19
Answer to case of the month #122. Orbital capillary hemangioma with magnetic resonance interleaving artifact. (18186436)
2007
20
Proximal nerve root capillary hemangioma presenting as a lung mass with bandlike chest pain: case report and review of literature. (16720181)
2006
21
Capillary hemangioma of the fourth ventricle in an infant. Case report and review of the literature. (16572636)
2006
22
Deletion (21)(q21.2q22.12) as a sole clonal cytogenetic abnormality in a lobular capillary hemangioma of the nasal cavity. (16965959)
2006
23
Imaging of the natural history of an orbital capillary hemangioma. (16527782)
2006
24
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
25
Retinal capillary hemangioma in von Hippel-Lindau disease. (16049535)
2005
26
Capillary hemangioma of the central nervous system. (15255254)
2004
27
Retinal capillary hemangioma managed by transpupillary thermotherapy. (15580006)
2004
28
Tracheal lobular capillary hemangioma: a rare cause of recurrent hemoptysis. (12796203)
2003
29
Ovarian capillary hemangioma and stromal luteinization: a case study with hormonal receptor evaluation. (11766743)
2001
30
Ovarian capillary hemangioma presenting as an adnexal mass with massive ascites and elevated CA-125. (10620457)
2000
31
Spinal intradural capillary hemangioma: MR findings. (10815676)
2000
32
Bronchial capillary hemangioma in adults. (10491024)
1999
33
Lobular capillary hemangioma of the cauda equina. Case report. (10199255)
1999
34
Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ. (9446823)
1998
35
Ruthenium-106 brachytherapy for peripheral retinal capillary hemangioma. (9709747)
1998
36
No role for human herpes virus 8 in the etiology of infantile capillary hemangioma. (9237177)
1997
37
Capillary hemangioma--report of a case. (9522754)
1996
38
Topical treatment of periocular capillary hemangioma. (7931948)
1994
39
Capillary hemangioma of the optic disc associated with a total retinal detachment. (8259247)
1993
40
Retinal capillary hemangioma. (1813504)
1991
41
Giant congenital capillary hemangioma of pericranium--case report. (1714050)
1990
42
Disseminated lobular capillary hemangioma (pyogenic granuloma). A clinicopathologic study of two cases. (3777375)
1986
43
Superficial spreading capillary hemangioma. A peculiar type of capillary hemangioma. (3949054)
1986
44
Mixed cavernous and capillary hemangioma of the frontal bone. (4064976)
1985
45
Capillary hemangioma of the optic disc. (6238051)
1984
46
Capillary hemangioma of the tympanic membrane. (646727)
1978
47
Capillary hemangioma of the uterine cervix: an unusual cause of vaginal bleeding in a child. (1245982)
1976
48
Post-traumatic capillary hemangioma of the hand. A case report. (4434047)
1974
49
Unilateral mixed sclerosing bone dystrophy associated with unilateral lymphangiectasis and capillary hemangioma: a case report. (5055176)
1972
50
Concerning a case of capillary hemangioma of the lung. (13397449)
1957

Genetic Variations for Capillary Hemangioma

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Expression for genes affiliated with Capillary Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for genes affiliated with Capillary Hemangioma

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4Cell Signaling Technology, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 49PharmGKB, 55SinoBiological, 53Reactome, 29KEGG
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Compounds for genes affiliated with Capillary Hemangioma

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4F8
2vegfc2810.3KDR, FLT4
3vegfe2810.3KDR, FLT4
4Pazopanib1110.1KDR, FLT4
5Ponatinib 1110.0TEK, KDR
6Regorafenib1110.0TEK, KDR, FLT4
7su6668449.9VEGFA, KDR
8ptk787449.9VEGFA, KDR
9Vandetanib119.8TEK, VEGFA
10capecitabine44 49 1111.8TYMP, VEGFA
11taxane449.7VEGFA, TYMP, KDR
12erlotinib44 49 1111.7KDR, TYMP, VEGFA
13leucovorin44 49 1111.7VEGFA, TYMP, KDR
14azd 2171449.7FLT4, VEGFA, KDR
15zd6474449.7FLT4, VEGFA, KDR
16axitinib44 59 1111.7KDR, VEGFA, FLT4
17su5416449.7KDR, VEGFA, FLT4
18sunitinib44 49 1111.7KDR, VEGFA, FLT4
19gemcitabine44 49 1111.6VEGFA, TYMP, KDR
20cobalt chloride449.6VEGFA, SLC2A1
21sorafenib44 49 1111.6KDR, VEGFA, FLT4
22docetaxel44 49 59 1112.6KDR, TYMP, VEGFA
23vinorelbine44 1110.6TYMP, VEGFA
24cyclophosphamide44 49 1111.6F8, TYMP, KDR
25progestin449.4KDR, VEGFA, F8
26paclitaxel44 49 1111.3FLT4, VEGFA, TYMP, KDR
275fluorouracil449.2VEGFA, TYMP, KDR, SLC2A1
28xbai449.2SLC2A1, F8
29prostacyclin449.2F8, VEGFA, TYMP, KDR
30rapamycin449.1FLT4, VEGFA, KDR, SLC2A1
31matrigel449.1FLT4, VEGFA, TYMP, KDR, TEK
32thymidine44 2410.1TYMP, CD34, HBA2, KDR, TEK
33cisplatin44 49 59 1112.1SLC2A1, KDR, TYMP, VEGFA
34dexamethasone44 49 28 1111.9SLC2A1, KDR, VEGFA, F8
35ly294002448.9FLT4, VEGFA, TYMP, KDR, SLC2A1
36heparin44 28 11 2411.8SLC2A1, VEGFA, F8
37oxygen44 249.7TEK, SLC2A1, HBA1, HBA2, TYMP, FLT4
38cysteine448.7F8, TYMP, KDR, SLC2A1, TEK
39atp44 289.7F8, TYMP, HBA2, TAP1, SLC2A1
40paraffin448.1FLT4, VEGFA, TYMP, CD34, KDR, SLC2A1
41tyrosine447.2F8, FLT4, VEGFA, TYMP, CD34, HBA2
42vegf446.8TEK, F8, FLT4, PROX1, VEGFA, TYMP

GO Terms for genes affiliated with Capillary Hemangioma

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16Gene Ontology
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Cellular components related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.7TEK, KDR, CD34, PROM1, FLT4
2extracellular regionGO:0055767.9TEK, F8, FLT4, VEGFA, HBA2, KDR
3plasma membraneGO:0058867.1F8, FLT4, PROM1, CD34, TAP1, KDR

Biological processes related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:00194510.1FLT4, KDR
2negative regulation of endothelial cell apoptotic processGO:200035210.1KDR, TEK
3endothelium developmentGO:00315810.0KDR, CD34
4positive regulation of vasculogenesisGO:200121410.0CD34, KDR
5peptidyl-tyrosine phosphorylationGO:0181089.9TEK, KDR, FLT4
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.9FLT4, KDR, TEK
7positive regulation of intracellular protein kinase cascadeGO:0107409.9VEGFA, TEK
8positive regulation of positive chemotaxisGO:0509279.9VEGFA, KDR
9surfactant homeostasisGO:0431299.8VEGFA, KDR
10sprouting angiogenesisGO:0020409.8FLT4, TEK
11endothelial cell proliferationGO:0019359.8CD34, TEK
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TEK, KDR, FLT4
13positive regulation of protein kinase C signaling cascadeGO:0900379.8FLT4, VEGFA
14cell migration involved in sprouting angiogenesisGO:0020429.7KDR, VEGFA
15positive regulation of focal adhesion assemblyGO:0518949.7TEK, KDR, VEGFA
16cellular response to vascular endothelial growth factor stimulusGO:0359249.6KDR, VEGFA, FLT4
17vascular endothelial growth factor receptor signaling pathwayGO:0480109.6FLT4, VEGFA, KDR
18branching morphogenesis of an epithelial tubeGO:0487549.6KDR, VEGFA
19retina morphogenesis in camera-type eyeGO:0600429.6PROM1, PROX1
20lymphangiogenesisGO:0019469.5PROX1, FLT4
21protein autophosphorylationGO:0467779.5TEK, KDR, FLT4
22angiogenesisGO:0015259.4VEGFA, TYMP, KDR, TEK
23positive regulation of protein phosphorylationGO:0019349.3FLT4, VEGFA, KDR, TEK
24positive regulation of angiogenesisGO:0457669.1VEGFA, CD34, KDR, TEK
25negative regulation of apoptotic processGO:0430668.7FLT4, VEGFA, KDR, TEK
26positive regulation of endothelial cell migrationGO:0105958.5TEK, KDR, VEGFA, PROX1, FLT4
27positive regulation of endothelial cell proliferationGO:0019388.5FLT4, PROX1, VEGFA, KDR, TEK
28positive regulation of cell proliferationGO:0082848.5KDR, VEGFA, PROX1, FLT4

Molecular functions related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.9KDR, FLT4
2growth factor bindingGO:0198389.9KDR, FLT4
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6TEK, KDR, FLT4
4platelet-derived growth factor receptor bindingGO:0051619.3TYMP, VEGFA
5protein bindingGO:0055156.0PROX1, PROM1, FLT4, F8, VEGFA, HBA2

Products for genes affiliated with Capillary Hemangioma

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Sources for Capillary Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet