MCID: CPL006
MIFTS: 49

Capillary Hemangioma malady

Summaries for Capillary Hemangioma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A capillary hemangioma (also known as an \"Infantile hemangioma,\" \"Strawberry hemangioma\", and... more...

MalaCards: Capillary Hemangioma, also known as strawberry nevus of skin, is related to pyogenic granuloma and hemangioma, capillary infantile. An important gene associated with Capillary Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are Tyrosine Kinases / Adaptors and Akt Signaling Pathway . The compounds estrogen and vegfe have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and integument.

Aliases & Classifications for Capillary Hemangioma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

capillary hemangioma 8 10
strawberry nevus of skin 8 61
cellular hemangioma of infancy 8
congenital vascular hamartoma 8
congenital vascular naevus 8
strawberry haemangioma 8
infantile hemangioma 8
hemangioma capillary 45
juvenile hemangioma 8
strawberry nevus 8


External Ids:

Disease Ontology8 DOID:2725
MeSH35 D018324
NCIt40 C6645

Related Diseases for Capillary Hemangioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1pyogenic granuloma31.0TEK, SLC2A1, CD34, FLT4
2hemangioma, capillary infantile30.8KDR, FLT4
3hemangioma, capillary infantile, somatic30.3FLT4, KDR
4klippel-trenaunay syndrome30.3FLT4
5renal clear cell carcinoma30.0VEGFA, KDR, SLC2A1
6hemangioendothelioma30.0FLT4, CD34
7acquired hemangioma10.5
8breast capillary hemangioma10.3
9tufted angioma10.3
10giant hemangioma10.3
11central nervous system hemangioma10.3
12phace syndrome10.3
13intramuscular hemangioma10.2
14n syndrome10.2
15astigmatism10.2
16internal carotid agenesis10.2
17castleman's disease10.2
18capillary malformations, congenital, 1, somatic, mosaic10.2
19melorheostosis with osteopoikilosis10.2
20giant infantile hemangioma10.2
21thrombocytopenia-absent radius syndrome10.0
22smith-lemli-opitz syndrome10.0
23cardiac tamponade10.0
24williams-beuren syndrome10.0
25rubinstein-taybi syndrome10.0
26gastric hemangioma10.0
27klinefelter's syndrome10.0
28bannayan-riley-ruvalcaba syndrome10.0
29nasal cavity inverting papilloma10.0
30incontinentia pigmenti achromians10.0
31cryptorchidism10.0
32radiculopathy10.0
33tuberous sclerosis10.0
34wolf-hirschhorn syndrome10.0
35branchiooculofacial syndrome10.0
36patau syndrome10.0
37hyperandrogenism10.0
38exophthalmos10.0
39gastric antral vascular ectasia10.0
40angiodysplasia10.0
41angioma serpiginosum10.0
42beckwith-wiedemann syndrome10.0
43syringocystadenoma papilliferum10.0
44roberts syndrome10.0
45stickler syndrome10.0
46otospondylomegaepiphyseal dysplasia10.0
47von hippel-lindau disease10.0
48poems syndrome10.0
49horner's syndrome10.0
50ollier disease10.0

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to capillary hemangioma

Clinical Features for Capillary Hemangioma

Drugs & Therapeutics for Capillary Hemangioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Capillary Hemangioma

Drug clinical trials:

Search ClinicalTrials for Capillary Hemangioma

Search NIH Clinical Center for Capillary Hemangioma

Search CenterWatch for Capillary Hemangioma

Genetic Tests for Capillary Hemangioma

Anatomical Context for Capillary Hemangioma

Animal Models for Capillary Hemangioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Capillary Hemangioma

Sources:
51PubMed
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Articles related to Capillary Hemangioma:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Imaging of intravenous lobular capillary hemangioma of azygos vein. (23877514)
2014
2
A suspicious breast lesion detected by dynamic contrast-enhanced MRI and pathologically confirmed as capillary hemangioma: a case report and literature review. (24265560)
2013
3
Purely Cutaneous Rosai-Dorfman disease (CRDD) co-existed with capillary hemangioma successfully treated with intralesional corticosteroid. (24164002)
2013
4
Routine and dynamic MR imaging study of lobular capillary hemangioma of the nasal cavity with comparison to inverting papilloma. (23703148)
2013
5
Primary Surgical Excision for Pediatric Orbital Capillary Hemangioma. (24117453)
2013
6
Rare case of multiple pulmonary artery aneurysms with mural thrombus and right ventricle capillary hemangioma. (23924481)
2013
7
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
8
Rapid regrowth of a capillary hemangioma of the thoracic spinal cord. (23006883)
2012
9
Testicular capillary hemangioma presenting as an incidental contralateral lesion in a child with cryptorchidism. (22990059)
2012
10
Lobular capillary hemangioma of middle turbinate literature survey and case report. (24303384)
2012
11
Changes in CT density of solitary capillary hemangioma of the lung upon varying patient position. (22875585)
2012
12
Intravitreal ranibizumab, photodynamic therapy, and vitreous surgery for the treatment of juxtapapillary retinal capillary hemangioma. (20676670)
2011
13
Intravenous lobular capillary hemangioma. (20494549)
2010
14
Recurrent pulmonary capillary hemangiomatosis after bilateral lung transplantation. (20445464)
2010
15
Lobular capillary hemangioma of the trachea: the second case. (23168891)
2010
16
Exudative retinal detachment following photodynamic therapy for retinal capillary hemangioma. (20436538)
2010
17
Capillary hemangioma of the thoracic spinal cord. (21082058)
2010
18
Radiology quiz case 2. Lobular capillary hemangioma (LCH). (21079173)
2010
19
Pulmonary capillary hemangiomatosis associated with CREST syndrome: a case report and review of the literature. (20453487)
2010
20
Acquired capillary hemangioma of the eyelid in a child. (19343976)
2009
21
Lobular capillary hemangioma of the liver. (19502177)
2009
22
Lumbar epidural capillary hemangioma presenting as lumbar disc herniation disease: case report. (18827685)
2008
23
Multiple capillary hemangiomas: a distinctive lesion of multicentric Castleman's disease and POEMS syndrome. (18797059)
2008
24
Clinical challenges and images in GI. Capillary hemangioma of small intestine. (17484862)
2007
25
A potential therapeutic strategy for capillary hemangioma with new anti-vascular endothelial growth factor (anti-VEGF) agents. (17408872)
2007
26
Lobular capillary hemangioma of the nasal cavity: A retrospective study on 40 patients. (16955784)
2006
27
Retinal capillary hemangiomas and von Hippel-Lindau disease. (16912012)
2006
28
Deletion (21)(q21.2q22.12) as a sole clonal cytogenetic abnormality in a lobular capillary hemangioma of the nasal cavity. (16965959)
2006
29
Capillary hemangioma of the cauda equina presenting with radiculopathy and papilledema. (16845308)
2006
30
Capillary hemangioma of the middle ear. (16929999)
2006
31
Unusual case of laryngeal tumor (capillary hemangioma) obturating the larynx. (16142096)
2005
32
Retinal capillary hemangioma in von Hippel–Lindau disease. (16116503)
2005
33
Retinal capillary hemangioma managed by transpupillary thermotherapy. (15580006)
2004
34
Pulmonary capillary hemangiomatosis associated with primary pulmonary hypertension: report of 2 new cases and review of 35 cases from the literature. (12441898)
2002
35
Retinal capillary hemangioma treated with verteporfin photodynamic therapy. (12429270)
2002
36
Pulmonary edema complicating prostacyclin therapy in pulmonary hypertension associated with scleroderma: a case of pulmonary capillary hemangiomatosis. (10728766)
2000
37
Pulmonary capillary hemangiomatosis in an asymptomatic elderly patient. (10408291)
1999
38
Testicular capillary hemangioma: an unusual diagnosis suggested by duplex color flow ultrasound findings. (9120981)
1997
39
Capillary hemangioma--report of a case. (9522754)
1996
40
Intramedullary disseminated capillary hemangioma with localized spinal cord swelling: case report. (8133997)
1993
41
Capillary hemangioma in the cauda equina: neuroradiological findings. (1749484)
1991
42
Splenic hamartoma and capillary hemangioma are distinct entities: immunohistochemical analysis of CD8 expression by endothelial cells. (1748432)
1991
43
Giant congenital capillary hemangioma of pericranium--case report. (1714050)
1990
44
Capillary hemangioma (strawberry mark) of infancy: comparison of argon and Nd:YAG laser treatment. (2734405)
1989
45
Capillary hemangioma of the kidney. Nephrectomy as consequence of a state of emergency. (3431894)
1987
46
Capillary hemangioma of the optic disc. (6238051)
1984
47
Subcutaneous granuloma pyogenicum. Lobular capillary hemangioma. (7059197)
1982
48
Capillary hemangioma of the lids and orbit: an analysis of the clinical features and therapeutic results in 101 cases. (545208)
1979
49
Conservative management of cutaneous capillary hemangioma. (13943117)
1963
50
Capillary hemangioma treated by radioactive P32. (14403640)
1960

Genetic Variations for Capillary Hemangioma

Expression for genes affiliated with Capillary Hemangioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for genes affiliated with Capillary Hemangioma

Sources:
4Cell Signaling Technology, 53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 50PharmGKB, 56SinoBiological, 54Reactome, 30KEGG
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Compounds for genes affiliated with Capillary Hemangioma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB
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Compounds related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1estrogen4510.4F8
2vegfe2910.3KDR, FLT4
3vegfc2910.3FLT4, KDR
4Pazopanib1110.1FLT4, KDR
5Ponatinib 1110.0KDR, TEK
6Regorafenib1110.0FLT4, KDR, TEK
7ptk787459.9KDR, VEGFA
8su6668459.9VEGFA, KDR
9Vandetanib119.8TEK, VEGFA
10capecitabine45 50 1111.8VEGFA, TYMP
11taxane459.7VEGFA, KDR, TYMP
12erlotinib45 50 1111.7KDR, TYMP, VEGFA
13leucovorin45 50 1111.7TYMP, KDR, VEGFA
14azd 2171459.7FLT4, VEGFA, KDR
15zd6474459.7KDR, FLT4, VEGFA
16axitinib45 60 1111.7FLT4, VEGFA, KDR
17su5416459.7KDR, VEGFA, FLT4
18sunitinib45 50 1111.7KDR, VEGFA, FLT4
19gemcitabine45 50 1111.6KDR, TYMP, VEGFA
20cobalt chloride459.6VEGFA, SLC2A1
21sorafenib45 50 1111.6VEGFA, KDR, FLT4
22docetaxel45 50 60 1112.6KDR, VEGFA, TYMP
23vinorelbine45 1110.6TYMP, VEGFA
24cyclophosphamide45 50 1111.6KDR, TYMP, F8
25progestin459.4F8, VEGFA, KDR
26paclitaxel45 50 1111.3TYMP, VEGFA, FLT4, KDR
275fluorouracil459.2SLC2A1, VEGFA, TYMP, KDR
28xbai459.2F8, SLC2A1
29prostacyclin459.2KDR, TYMP, VEGFA, F8
30rapamycin459.1FLT4, VEGFA, KDR, SLC2A1
31matrigel459.1VEGFA, FLT4, TEK, TYMP, KDR
32thymidine45 2410.1TYMP, CD34, TEK, HBA2, KDR
33cisplatin45 50 60 1112.1VEGFA, TYMP, KDR, SLC2A1
34dexamethasone45 50 29 1111.9F8, VEGFA, SLC2A1, KDR
35ly294002458.9SLC2A1, KDR, TYMP, VEGFA, FLT4
36heparin45 29 11 2411.8VEGFA, F8, SLC2A1
37oxygen45 249.7FLT4, TYMP, HBA1, SLC2A1, TEK, HBA2
38cysteine458.7SLC2A1, KDR, TYMP, F8, TEK
39atp45 299.7HBA2, TYMP, F8, SLC2A1, TAP1
40paraffin458.1TEK, SLC2A1, FLT4, KDR, VEGFA, TYMP
41tyrosine457.2FLT4, VEGFA, TYMP, CD34, HBA2, KDR
42vegf456.8FLT4, F8, PROX1, VEGFA, TYMP, CD34

GO Terms for genes affiliated with Capillary Hemangioma

Sources:
16Gene Ontology
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Cellular components related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.7TEK, KDR, CD34, PROM1, FLT4
2extracellular regionGO:0055767.9TEK, F8, FLT4, VEGFA, HBA2, KDR
3plasma membraneGO:0058867.1F8, FLT4, PROM1, CD34, TAP1, KDR

Biological processes related to Capillary Hemangioma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:00194510.1FLT4, KDR
2negative regulation of endothelial cell apoptotic processGO:200035210.1KDR, TEK
3endothelium developmentGO:00315810.0KDR, CD34
4positive regulation of vasculogenesisGO:200121410.0CD34, KDR
5peptidyl-tyrosine phosphorylationGO:0181089.9TEK, KDR, FLT4
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.9FLT4, KDR, TEK
7positive regulation of intracellular protein kinase cascadeGO:0107409.9VEGFA, TEK
8positive regulation of positive chemotaxisGO:0509279.9VEGFA, KDR
9surfactant homeostasisGO:0431299.8VEGFA, KDR
10sprouting angiogenesisGO:0020409.8FLT4, TEK
11endothelial cell proliferationGO:0019359.8CD34, TEK
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TEK, KDR, FLT4
13positive regulation of protein kinase C signaling cascadeGO:0900379.8FLT4, VEGFA
14cell migration involved in sprouting angiogenesisGO:0020429.7KDR, VEGFA
15positive regulation of focal adhesion assemblyGO:0518949.7TEK, KDR, VEGFA
16cellular response to vascular endothelial growth factor stimulusGO:0359249.6KDR, VEGFA, FLT4
17vascular endothelial growth factor receptor signaling pathwayGO:0480109.6FLT4, VEGFA, KDR
18branching morphogenesis of an epithelial tubeGO:0487549.6KDR, VEGFA
19retina morphogenesis in camera-type eyeGO:0600429.6PROM1, PROX1
20lymphangiogenesisGO:0019469.5PROX1, FLT4
21protein autophosphorylationGO:0467779.5TEK, KDR, FLT4
22angiogenesisGO:0015259.4VEGFA, TYMP, KDR, TEK
23positive regulation of protein phosphorylationGO:0019349.3FLT4, VEGFA, KDR, TEK
24positive regulation of angiogenesisGO:0457669.1VEGFA, CD34, KDR, TEK
25negative regulation of apoptotic processGO:0430668.7FLT4, VEGFA, KDR, TEK
26positive regulation of endothelial cell migrationGO:0105958.5TEK, KDR, VEGFA, PROX1, FLT4
27positive regulation of endothelial cell proliferationGO:0019388.5FLT4, PROX1, VEGFA, KDR, TEK
28positive regulation of cell proliferationGO:0082848.5KDR, VEGFA, PROX1, FLT4

Molecular functions related to Capillary Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.9KDR, FLT4
2growth factor bindingGO:0198389.9KDR, FLT4
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6TEK, KDR, FLT4
4platelet-derived growth factor receptor bindingGO:0051619.3TYMP, VEGFA
5protein bindingGO:0055156.0PROX1, PROM1, FLT4, F8, VEGFA, HBA2

Products for genes affiliated with Capillary Hemangioma

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Sources for Capillary Hemangioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet