MCID: CPL006
MIFTS: 51

Capillary Hemangioma malady

Categories: Cardiovascular diseases, Cancer diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Capillary Hemangioma

Aliases & Descriptions for Capillary Hemangioma:

Name: Capillary Hemangioma 12 14
Strawberry Nevus of Skin 12 69
Cellular Hemangioma of Infancy 12
Congenital Vascular Hamartoma 12
Congenital Vascular Naevus 12
Strawberry Haemangioma 12
Hemangioma, Cavernous 69
Hemangioma, Capillary 42
Infantile Hemangioma 12
Hemangioma Capillary 52
Juvenile Hemangioma 12
Strawberry Nevus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2725
ICD10 33 Q82.5
MeSH 42 D018324
NCIt 47 C6645
UMLS 69 C0206733

Summaries for Capillary Hemangioma

MalaCards based summary : Capillary Hemangioma, also known as strawberry nevus of skin, is related to breast capillary hemangioma and pyogenic granuloma. An important gene associated with Capillary Hemangioma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Ras signaling pathway and PI3K-Akt signaling pathway. The drugs Timolol and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and cardiovascular system

Wikipedia : 71 A capillary hemangioma (also known as an Infantile hemangioma,Strawberry hemangioma, and Strawberry... more...

Related Diseases for Capillary Hemangioma

Diseases in the Capillary Hemangioma family:

Hemangioma, Capillary Infantile

Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
id Related Disease Score Top Affiliating Genes
1 breast capillary hemangioma 12.0
2 pyogenic granuloma 11.7
3 hemangioma, capillary infantile 11.5
4 capillary malformations, congenital, 1, somatic, mosaic 11.1
5 angioma, tufted 10.9
6 cerebral cavernous malformations-1 10.9
7 hemangioma 10.9
8 retinitis 10.4
9 degenerative disc disease 10.2 TEK VEGFA
10 hand, foot and mouth disease 10.2 KDR VEGFA
11 pustulosis palmaris et plantaris 10.2 KDR PECAM1
12 radiation induced angiosarcoma of the breast 10.2 TEK VEGFA
13 cone-rod dystrophy 17 10.2 KDR VEGFA
14 arrhythmogenic right ventricular dysplasia 3 10.2 HBA1 KDR
15 pulmonary blastoma 10.2 KDR TEK
16 common variable immunodeficiency 10.2 TEK VEGFA
17 mucoepidermoid esophageal carcinoma 10.2 SLC2A1 TEK
18 thyroid angiosarcoma 10.2 HBA1 VEGFA
19 alcohol-induced mental disorder 10.2 HBA1 KDR
20 klatskin's tumor 10.2 SLC2A1 VEGFA
21 laryngeal adenoid cystic carcinoma 10.2 HBA1 VEGFA
22 biemond syndrome ii 10.2 KDR VEGFA
23 craniosynostosis, type 1 10.2 RASA1 VEGFA
24 retinal degeneration 10.1 TEK VEGFA
25 subdural empyema 10.1 KDR TEK VEGFA
26 oppositional defiant disorder 10.1 KDR TEK VEGFA
27 vulvitis 10.1 KDR TEK VEGFA
28 albinism, oculocutaneous, type ib 10.1 KDR TEK VEGFA
29 citrullinemia, type ii, neonatal-onset 10.1 KDR TEK VEGFA
30 neuropathy with hearing impairment 10.1 KDR PECAM1 VEGFA
31 benign idiopathic neonatal seizures 10.1 KDR PECAM1 VEGFA
32 lmna-related cardiocutaneous progeria syndrome 10.1 HBA1 RASA1
33 phlegmonous dacryocystitis 10.1 KDR VEGFA
34 charcot-marie-tooth disease, axonal, type 2f 10.1 KDR PECAM1
35 uterine benign neoplasm 10.1 HBA1 SLC2A1 TEK
36 conventional leiomyosarcoma 10.1 HBA1 SLC2A1 TEK
37 hyperpituitarism 10.1 HBA1 SLC2A1 TEK
38 neurilemmoma of the pleura 10.1 HBA1 KDR VEGFA
39 gapo syndrome 10.1 FLT4 KDR
40 eosinophilic pneumonia 10.1 FLT4 KDR
41 vernal conjunctivitis 10.1 HBA1 KDR VEGFA
42 corneal dystrophy 10.1 FLT4 SLC2A1
43 mucinous ovarian cystadenoma 10.1 KDR TEK VEGFA
44 mental retardation, autosomal recessive 27 10.0 KDR PROM1 VEGFA
45 heavy chain disease 10.0 HBA1 SLC2A1
46 ovarian disease 10.0 KDR VEGFA
47 pituitary infarct 10.0 RASA1 TEK VEGFA
48 intracranial cysts 10.0 FLT4 VEGFA
49 hyperbetaalaninemia 10.0 HBA1 RASA1
50 phencyclidine abuse 10.0 FLT4 HBA1

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to Capillary Hemangioma

Symptoms & Phenotypes for Capillary Hemangioma

GenomeRNAi Phenotypes related to Capillary Hemangioma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.28 SLC2A1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.28 EGFL7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.28 EGFL7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.28 HBA1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.28 SLC2A1 EGFL7 HBA1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.28 SLC2A1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.28 HBA1

MGI Mouse Phenotypes related to Capillary Hemangioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 EGFL7 FLT4 KDR PECAM1 PROM1 RASA1
2 mortality/aging MP:0010768 9.86 KDR PROM1 RASA1 SLC2A1 TEK VEGFA
3 embryo MP:0005380 9.8 FLT4 KDR RASA1 SLC2A1 TEK VEGFA
4 muscle MP:0005369 9.63 FLT4 KDR PECAM1 RASA1 TEK VEGFA
5 no phenotypic analysis MP:0003012 9.5 VEGFA EGFL7 FLT4 KDR PROM1 RASA1
6 normal MP:0002873 9.1 EGFL7 FLT4 KDR PROM1 TEK VEGFA

Drugs & Therapeutics for Capillary Hemangioma

Drugs for Capillary Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 3,Phase 2,Phase 1,Early Phase 1 26839-75-8 33624 5478
2
Ephedrine Approved Phase 3 299-42-3 9294
3
Pseudoephedrine Approved Phase 3 90-82-4 7028
4
Propranolol Approved, Investigational Phase 2, Phase 3, Phase 1 525-66-6 4946
5
Nadolol Approved Phase 3,Phase 2 42200-33-9 39147
6
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
7
Atenolol Approved Phase 3 29122-68-7 2249
8
Acebutolol Approved Phase 3 37517-30-9 1978
9 tannic acid Approved, Nutraceutical Phase 3
10
Maleic acid Experimental Phase 3,Phase 2,Phase 1 110-16-7 444266
11 Adrenergic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
12 Adrenergic Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
13 Adrenergic beta-Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
14 Anti-Arrhythmia Agents Phase 3,Phase 2,Phase 1,Early Phase 1
15 Antihypertensive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
16 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
17 Autonomic Agents Phase 3,Phase 2
18 Nasal Decongestants Phase 3
19 Ophthalmic Solutions Phase 3
20 Peripheral Nervous System Agents Phase 3,Phase 2
21 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
22 Respiratory System Agents Phase 3
23 Tetrahydrozoline Phase 3
24 Vasoconstrictor Agents Phase 3
25 Vasodilator Agents Phase 2, Phase 3, Phase 1
26 Sympatholytics Phase 3,Phase 2
27 Adrenergic beta-1 Receptor Antagonists Phase 3
28 Adrenergic Agonists Phase 3
29 Adrenergic alpha-2 Receptor Agonists Phase 3
30 Adrenergic alpha-Agonists Phase 3
31 Brimonidine Tartrate Phase 3 70359-46-5
32
Bosentan Approved, Investigational Phase 2 147536-97-8 104865
33
Imiquimod Approved, Investigational Phase 2 99011-02-6 57469
34
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
35
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
36
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
37
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
38
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
39
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
40
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
41
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
42
Bleomycin Approved Phase 2 11056-06-7 5360373
43
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
44
Ranitidine Approved Phase 2 66357-59-3, 66357-35-5 3001055
45
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
46
Pancrelipase Approved Phase 2 53608-75-6
47
Vatalanib Investigational Phase 2 212141-54-3 151194
48 Endothelin Receptor Antagonists Phase 2
49 Adjuvants, Immunologic Phase 2
50 Interferon Inducers Phase 2

Interventional clinical trials:

(show top 50) (show all 93)
id Name Status NCT ID Phase
1 A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain Not yet recruiting NCT03125057 Phase 4
2 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Not yet recruiting NCT03181984 Phase 4
3 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3
4 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3
5 Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Completed NCT01056341 Phase 2, Phase 3
6 Nadolol Versus Propranolol in Children With Infantile Hemangiomas Recruiting NCT02505971 Phase 3
7 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Recruiting NCT02342275 Phase 3
8 MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients Not yet recruiting NCT02962947 Phase 2, Phase 3
9 Onreltea (Brimonidine) Gel In Pediatric Patients With Capillary Malformations Not yet recruiting NCT02764411 Phase 3
10 Propranolol in Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3
11 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3
12 Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study Unknown status NCT02317679 Phase 2
13 Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo Completed NCT01512173 Phase 2
14 Nadolol for Proliferating Infantile Hemangiomas Completed NCT01010308 Phase 2
15 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2
16 The Effects of Aldara as an Adjunct to Laser Treatment Completed NCT00979550 Phase 2
17 Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma Completed NCT01072045 Phase 2
18 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2
19 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
20 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2
21 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2
22 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2
23 Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) Recruiting NCT02913612 Phase 2
24 Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Recruiting NCT02731287 Phase 2
25 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Recruiting NCT02859441 Phase 1, Phase 2
26 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2
27 Electrosclerotherapy for Capillary Malformations Not yet recruiting NCT02883023 Phase 2
28 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Tria Not yet recruiting NCT02732678 Phase 1, Phase 2
29 Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH) Terminated NCT01074437 Phase 2
30 Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas Terminated NCT00555464 Phase 2
31 Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow Terminated NCT00330564 Phase 2
32 Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks Withdrawn NCT00969397 Phase 1, Phase 2
33 Timolol Option for Ulcerated Hemangiomas (TOUCH Trial) Withdrawn NCT01408056 Phase 2
34 Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS) Withdrawn NCT01997255 Phase 2
35 A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks. Completed NCT00800722 Phase 1
36 Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks: Comparison of 577 nm Versus 595 nm Wavelengths Completed NCT00573729 Phase 1
37 A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks. Completed NCT00830466 Phase 1
38 Treatment of Vascular Lesions With a Tandem 532/1064 nm Laser Completed NCT00585338 Phase 1
39 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
40 Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples Recruiting NCT02051101 Phase 1
41 Combined Bipolar Radiofrequency&Pulsed Dye Laser Treatment Recruiting NCT01775722 Phase 1
42 Novel Treatment for Port Wine Stain Birthmarks Recruiting NCT01924273 Phase 1
43 Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only) Enrolling by invitation NCT02108002 Phase 1
44 Timolol for the Prevention of Proliferation of Infantile Hemangioma (TiPPIH Trial) Terminated NCT01434849 Phase 1
45 Combined Alexandrite and Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks Withdrawn NCT00580944 Phase 1
46 Combined Pulsed Dye Laser and Topical Ranibizumab for Treatment of Port Wine Stain Birthmarks Withdrawn NCT00667472 Phase 1
47 Pilot Study on the Use of the Matrix Radiofrequencyfor Treatment of Port Wine Stain Birthmarks Withdrawn NCT01166919 Phase 1
48 Topical Timolol 0.5% Solution for Proliferating Infantile Hemangiomas Unknown status NCT01147601 Early Phase 1
49 The Angioma's Treatment Evaluation With Laser Doppler Imaging (LDI) Unknown status NCT01759082
50 Evaluation and Optimization of the Technical and Clinical Performance of the Lumenis ONE Platform Unknown status NCT00247299

Search NIH Clinical Center for Capillary Hemangioma

Cochrane evidence based reviews: hemangioma, capillary

Genetic Tests for Capillary Hemangioma

Anatomical Context for Capillary Hemangioma

MalaCards organs/tissues related to Capillary Hemangioma:

39
Skin, Lung, Testis, Spinal Cord, Bone, Liver, Retina

Publications for Capillary Hemangioma

Articles related to Capillary Hemangioma:

(show top 50) (show all 409)
id Title Authors Year
1
A Case of Giant Intradural Extramedullary Capillary Hemangioma. ( 28091424 )
2017
2
Intracranial Capillary Hemangioma in the Posterior Fossa of an Adult Male. ( 27747124 )
2016
3
Juvenile capillary hemangioma. ( 27057499 )
2016
4
Capillary hemangioma or pyogenic granuloma. ( 27041829 )
2016
5
A case of giant fetal intracranial capillary hemangioma cured with propranolol. ( 26824594 )
2016
6
Intradural extramedullary capillary hemangioma: A case report and review of the literature. ( 27073572 )
2016
7
Pleural effusion caused by a capillary hemangioma in the pleural cavity. ( 27087237 )
2016
8
How to manage testicular capillary haemangioma: Editorial Comment on: W. BiaA8ek, S. Rudzki, L. Wroniecki: Capillary hemangioma of the testis. A case report of a rare benign tumor. ( 27104008 )
2016
9
Multiparametric sonographic imaging of a capillary hemangioma of the testis: appearances on gray-scale, color Doppler, contrast-enhanced ultrasound and strain elastography. ( 26941881 )
2016
10
Intracranial capillary hemangioma misdiagnosed as a meningioma. ( 27097011 )
2016
11
Lobular capillary hemangioma of the tracheobronchial tree: A case report and literature review. ( 27902613 )
2016
12
Capillary Hemangioma of the Breast-a Rare Type of benign Breast Tumor. ( 26687640 )
2016
13
Lobular Capillary Hemangioma Originating From the Posterior Portion of the Inferior Turbinate. ( 27483103 )
2016
14
Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia. ( 27403353 )
2016
15
Intravitreal bevacizumab and feeder vessel laser treatment for a posteriorly located retinal capillary hemangioma. ( 26815929 )
2016
16
Solitary Pulmonary Capillary Hemangioma of Adult Cases: Clinicopathologic Characteristics as an Unrecognized Entity. ( 27454944 )
2016
17
Case report of lumbar intradural capillary hemangioma. ( 27069745 )
2016
18
Intravascular Lobular Capillary Hemangioma in the Corpus Spongiosum. ( 26730699 )
2016
19
Intradural Extramedullary Capillary Hemangioma in the Upper Cervical Spine: First Report. ( 27185649 )
2016
20
Spinal Intradural Extramedulary Capillary Hemangioma Mimicking Meningioma. ( 27799982 )
2016
21
Capillary Hemangioma of the Fallopian Tube. ( 27190899 )
2016
22
Capillary hemangioma of the testis. A case report of a rare benign tumor. ( 27104006 )
2016
23
Lobular Capillary Hemangioma ("Pyogenic Granuloma") of the Trachea. ( 27014842 )
2016
24
Intravenous Lobular Capillary Hemangioma in the Subclavian Vein. ( 27772599 )
2016
25
Pediatric intranasal lobular capillary hemangioma: Report of two new cases and review of the literature. ( 27144115 )
2016
26
Tracheal lobular capillary hemangioma treated with laser photocoagulation. ( 26982046 )
2016
27
Intradural extramedullary capillary hemangioma of the cauda equina: Case report and literature review. ( 25949855 )
2015
28
Unusual intraosseous capillary hemangioma of the mandible. ( 26430377 )
2015
29
Posterior mediastinal capillary hemangioma misdiagnosed as neurofibromas: a rare case report and review of the literature. ( 25918608 )
2015
30
Lobular capillary hemangioma of the trachea. ( 25644803 )
2015
31
Massive exudative retinal detachment following photodynamic therapy and intravitreal bevacizumab injection in retinal capillary hemangioma. ( 25829835 )
2015
32
Worsening headache and nasal congestion. Lobular capillary hemangioma. ( 25611752 )
2015
33
Atypical Presentation of Capillary Hemangioma in Oral Cavity- A Case Report. ( 26557632 )
2015
34
Not just a capillary hemangioma. ( 26547209 )
2015
35
Capillary hemangioma of the testis: A rare benign tumour. ( 26085871 )
2015
36
Capillary hemangioma of the cauda equina. ( 26322243 )
2015
37
Lobular capillary hemangioma formation: An unusual complication of submucous resection with power instrumentation of the inferior turbinate. ( 26403945 )
2015
38
Effects of oral propranolol on a juxtapapillary capillary hemangioma: a single-subject pilot study. ( 25856826 )
2015
39
A case of cord capillary hemangioma of the spleen: A recently proven true neoplasm. ( 25727477 )
2015
40
Recurrent lobular capillary hemangiomas in a patient with neurofibromatosis type 1 (NF1) and von Hippel-Lindau syndrome (VHL). ( 27051783 )
2015
41
Pre-operative effects of the administration of systemic corticosteroids combined with antibiotics on a lobular capillary hemangioma in the nasal cavity. ( 26307659 )
2015
42
Dumbbell-Shaped Epidural Capillary Hemangioma Presenting as a Lung Mass: Case Report and Review of the Literature. ( 25946721 )
2015
43
Intracranial capillary hemangioma in an elderly patient. ( 26664868 )
2015
44
Synchronous Hepatoblastoma, Neuroblastoma and Cutaneous Capillary Hemangiomas: A Case Review. ( 26368548 )
2015
45
Internal jugular vein pyogenic capillary hemangioma: a case report. ( 25462549 )
2015
46
A Rare Subglottic Capillary Hemangioma. ( 26121568 )
2015
47
Propranolol therapy in a case of capillary hemangioma. ( 26903730 )
2015
48
Case study of a spinal epidural capillary hemangioma: a 4-year postoperative follow-up. ( 24494182 )
2014
49
Treatment process for capillary hemangioma. ( 25254092 )
2014
50
Extragingival pyogenic granuloma histologically mimicking capillary hemangioma. ( 25425828 )
2014

Variations for Capillary Hemangioma

Cosmic variations for Capillary Hemangioma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM584 NRAS soft tissue,skin,haemangioma,capillary c.182A>G p.Q61R 7
2 COSM516 KRAS soft tissue,skin,haemangioma,capillary c.34G>T p.G12C 7
3 COSM529 KRAS soft tissue,skin,haemangioma,capillary c.37G>C p.G13R 7
4 COSM486 HRAS soft tissue,skin,haemangioma,capillary c.37G>C p.G13R 7
5 COSM499 HRAS soft tissue,skin,haemangioma,capillary c.182A>G p.Q61R 7
6 COSM52975 GNAQ soft tissue,skin,haemangioma,capillary c.548G>A p.R183Q 7
7 COSM449 BRAF soft tissue,skin,haemangioma,capillary c.1391G>A p.G464E 7
8 COSM476 BRAF soft tissue,skin,haemangioma,capillary c.1799T>A p.V600E 7

Expression for Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for Capillary Hemangioma

Pathways related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 FLT4 KDR RASA1 TEK VEGFA
2 12.29 FLT4 KDR TEK VEGFA
3
Show member pathways
12.15 FLT4 KDR VEGFA
4
Show member pathways
12.14 KDR RASA1 VEGFA
5
Show member pathways
12.1 FLT4 KDR VEGFA
6
Show member pathways
11.93 FLT4 KDR TEK
7 11.85 FLT4 KDR TEK
8 11.83 KDR PECAM1 VEGFA
9 11.8 KDR PROM1 VEGFA
10
Show member pathways
11.71 KDR RASA1 VEGFA
11 11.6 SLC2A1 TEK VEGFA
12 11.48 PROM1 SLC2A1 VEGFA
13
Show member pathways
11.42 FLT4 KDR RASA1 VEGFA
14 11.26 KDR VEGFA
15
Show member pathways
11.21 KDR VEGFA
16 11.2 FLT4 KDR PECAM1 TEK
17 11.14 RASA1 TEK
18 11.13 SLC2A1 VEGFA
19 11.03 KDR SLC2A1 VEGFA
20 10.81 KDR TEK VEGFA
21
Show member pathways
10 FLT4 KDR VEGFA

GO Terms for Capillary Hemangioma

Cellular components related to Capillary Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 EGFL7 FLT4 HBA1 KDR TEK VEGFA
2 integral component of plasma membrane GO:0005887 9.35 FLT4 KDR PROM1 SLC2A1 TEK
3 membrane raft GO:0045121 8.92 KDR PECAM1 SLC2A1 TEK

Biological processes related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.83 FLT4 KDR RASA1 TEK VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 FLT4 KDR TEK
3 protein autophosphorylation GO:0046777 9.76 FLT4 KDR TEK
4 peptidyl-tyrosine phosphorylation GO:0018108 9.75 FLT4 KDR TEK
5 regulation of cell shape GO:0008360 9.74 KDR RASA1 VEGFA
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.72 FLT4 KDR TEK
7 positive regulation of angiogenesis GO:0045766 9.71 KDR TEK VEGFA
8 positive regulation of protein phosphorylation GO:0001934 9.71 FLT4 KDR TEK VEGFA
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.65 FLT4 KDR VEGFA
10 angiogenesis GO:0001525 9.65 EGFL7 FLT4 KDR TEK VEGFA
11 blood vessel morphogenesis GO:0048514 9.61 FLT4 RASA1
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 KDR TEK
13 sprouting angiogenesis GO:0002040 9.59 FLT4 TEK
14 cell migration involved in sprouting angiogenesis GO:0002042 9.56 KDR VEGFA
15 positive regulation of focal adhesion assembly GO:0051894 9.54 KDR TEK VEGFA
16 positive regulation of positive chemotaxis GO:0050927 9.52 KDR VEGFA
17 positive regulation of protein kinase C signaling GO:0090037 9.51 FLT4 VEGFA
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.5 FLT4 KDR VEGFA
19 vascular endothelial growth factor signaling pathway GO:0038084 9.49 FLT4 KDR
20 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.46 KDR VEGFA
21 vasculogenesis GO:0001570 9.46 EGFL7 KDR RASA1 VEGFA
22 positive regulation of endothelial cell migration GO:0010595 9.26 FLT4 KDR TEK VEGFA
23 positive regulation of endothelial cell proliferation GO:0001938 9.02 EGFL7 FLT4 KDR TEK VEGFA

Molecular functions related to Capillary Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 FLT4 KDR TEK
2 vascular endothelial growth factor-activated receptor activity GO:0005021 9.16 FLT4 KDR
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 FLT4 KDR TEK
4 growth factor binding GO:0019838 8.8 FLT4 KDR TEK

Sources for Capillary Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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