MCID: CPL003
MIFTS: 44

Capillary Leak Syndrome

Categories: Rare diseases, Bone diseases, Cardiovascular diseases

Aliases & Classifications for Capillary Leak Syndrome

MalaCards integrated aliases for Capillary Leak Syndrome:

Name: Capillary Leak Syndrome 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14400
MeSH 41 D019559
NCIt 46 C62578
SNOMED-CT 64 87730004
UMLS 69 C0343084

Summaries for Capillary Leak Syndrome

MalaCards based summary : Capillary Leak Syndrome is related to hydrops, lactic acidosis, and sideroblastic anemia and perinatal necrotizing enterocolitis. An important gene associated with Capillary Leak Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Aldesleukin and Isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and bone marrow, and related phenotype is neoplasm.

Related Diseases for Capillary Leak Syndrome

Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 hydrops, lactic acidosis, and sideroblastic anemia 30.2 ALB C1S
2 perinatal necrotizing enterocolitis 30.0 CXCL8 IL6
3 brucellosis 29.8 CXCL8 IL2 IL6
4 peritonitis 29.8 ALB CXCL8 IL6
5 kawasaki disease 29.6 ALB ELANE IL6
6 hereditary angioedema 29.6 C1S C4A
7 psoriasis 29.5 CXCL8 ELANE IL2 IL6
8 adult respiratory distress syndrome 29.2 C4A CXCL8 ELANE IL6
9 myeloma, multiple 28.9 ALB CSF2 CXCL8 IL6
10 systemic capillary leak syndrome 12.7
11 dengue disease 11.0
12 pyuria 10.4 ALB CXCL8
13 noma 10.4 ALB CXCL8
14 euthyroid sick syndrome 10.4 ALB IL6
15 transient arthritis 10.3 ALB IL6
16 recurrent corneal erosion 10.3 CXCL8 IL6
17 bagassosis 10.3 CXCL8 IL6
18 acute transverse myelitis 10.3 CXCL8 IL6
19 pasteurellosis 10.3 ALB ELANE
20 hemorrhagic fever 10.3 ALB IL6
21 denture stomatitis 10.3 CXCL8 IL6
22 compartment syndrome 10.3
23 papillary conjunctivitis 10.3 CXCL8 IL6
24 funisitis 10.3 CXCL8 IL6
25 hand, foot and mouth disease 10.3 C4A IL6
26 prediabetes syndrome 10.3 ALB IL6
27 chronic ulcer of skin 10.3 ALB ELANE
28 hydrarthrosis 10.3 C4A IL6
29 vaginal disease 10.3 CXCL8 IL6
30 louse-borne relapsing fever 10.3 CXCL8 IL6
31 vaginitis 10.3 CXCL8 IL6
32 membranoproliferative glomerulonephritis 10.3 ALB C4A
33 toxicodendron dermatitis 10.3 CXCL8 IL2
34 preterm premature rupture of the membranes 10.3 CXCL8 IL6
35 endometrial disease 10.3 CXCL8 IL6
36 transverse myelitis 10.3 CXCL8 IL6
37 endotheliitis 10.3
38 pure red-cell aplasia 10.3 ALB IL2
39 cowpox 10.3 CXCL8 IL6
40 bacteriuria 10.3 CXCL8 IL6
41 trichomoniasis 10.3 CXCL8 IL2
42 hemorrhagic fever with renal syndrome 10.3 ALB IL6
43 pulpitis 10.3 CXCL8 IL6
44 protein-energy malnutrition 10.3 ALB IL6
45 cardiac rupture 10.3 CXCL8 ELANE
46 clonorchiasis 10.3 CXCL8 IL2
47 retinitis pigmentosa 44 10.3 CXCL8 IL2
48 cytomegalovirus infection 10.2 CXCL8 IL6
49 crohn's colitis 10.2 CXCL8 IL2
50 meningoencephalitis 10.2 ALB IL6

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to Capillary Leak Syndrome

Symptoms & Phenotypes for Capillary Leak Syndrome

MGI Mouse Phenotypes related to Capillary Leak Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 ELANE IL2 IL6 ALB CSF2

Drugs & Therapeutics for Capillary Leak Syndrome

Drugs for Capillary Leak Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aldesleukin Approved Phase 3,Phase 2 110942-02-4, 85898-30-2
2
Isotretinoin Approved Phase 3,Phase 2 4759-48-2 5282379 5538
3
Acetaminophen Approved Phase 3 103-90-2 1983
4
Codeine Approved, Illicit Phase 3 76-57-3 5284371
5
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
6
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
7
Ibuprofen Approved Phase 3 15687-27-1 3672
8
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 5538
11
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
12 Analgesics Phase 3,Phase 2
13 Analgesics, Non-Narcotic Phase 3,Phase 2
14 Antibodies Phase 3,Phase 2
15 Antibodies, Monoclonal Phase 3
16 Anti-HIV Agents Phase 3,Phase 2
17 Anti-Infective Agents Phase 3,Phase 2
18 Anti-Retroviral Agents Phase 3,Phase 2
19 Antiviral Agents Phase 3,Phase 2
20 Dermatologic Agents Phase 3,Phase 2
21 Immunoglobulins Phase 3,Phase 2
22 Interleukin-2 Phase 3,Phase 2
23 Keratolytic Agents Phase 3,Phase 2
24 Peripheral Nervous System Agents Phase 3,Phase 2
25 Retinol palmitate Phase 3
26 Vitamins Phase 3
27 Analgesics, Opioid Phase 3
28 Anti-Anxiety Agents Phase 3
29 Antiemetics Phase 3
30 Anti-Inflammatory Agents Phase 3
31 Anti-Inflammatory Agents, Non-Steroidal Phase 3
32 Antipruritics Phase 3
33 Antipsychotic Agents Phase 3
34 Antipyretics Phase 3
35 Antirheumatic Agents Phase 3
36 Antitussive Agents Phase 3
37 Autonomic Agents Phase 3
38 Central Nervous System Depressants Phase 3
39 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
40 Cyclooxygenase Inhibitors Phase 3
41 Dopamine Agents Phase 3
42 Dopamine Antagonists Phase 3
43 Dopamine D2 Receptor Antagonists Phase 3
44 Gastrointestinal Agents Phase 3
45 Narcotics Phase 3
46 Neurotransmitter Agents Phase 3
47 Psychotropic Drugs Phase 3
48 Respiratory System Agents Phase 3
49
Serotonin Phase 3 50-67-9 5202
50 Serotonin Agents Phase 3

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Completed NCT01041638 Phase 3 Isotretinoin
2 Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy Terminated NCT00147355 Phase 3 ondansetron, ibuprofen, paracetamol;Ondansetron, ibuprofen, paracetamol;metoclopramide, ibuprofen, paracetamol;Metoclopramide, codeine phosphate, ibuprofen, paracetamol
3 NB2013-HR German (GPOH) / Dutch (DCOG) Trial Terminated NCT02641782 Phase 2 antibody ch14.18;GM-CSF;IL-2 i.v.;IL-2 s.c.;Retinoic acid
4 DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma Completed NCT00889408 Phase 1
5 CAT-8015 in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma Completed NCT00659425 Phase 1 CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox)
6 Human Leukocyte Antigen (HLA) Class I Haplotype Mismatched Natural Killer Cell Infusions Completed NCT00660166 Phase 1
7 Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients Completed NCT03410771 Monitor antibiotic exposure (PK profile)
8 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Completed NCT03135496
9 Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia Completed NCT00167167
10 Studies in the Pathogenesis of Systemic Capillary Leak Syndrome Recruiting NCT00936325
11 Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery Recruiting NCT02853682
12 Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass Not yet recruiting NCT02965339

Search NIH Clinical Center for Capillary Leak Syndrome

Cochrane evidence based reviews: capillary leak syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

MalaCards organs/tissues related to Capillary Leak Syndrome:

38
Endothelial, Bone, Bone Marrow, T Cells, Lung, Breast, B Cells

Publications for Capillary Leak Syndrome

Articles related to Capillary Leak Syndrome:

(show top 50) (show all 242)
# Title Authors Year
1
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease). ( 29360169 )
2018
2
Raised Serum Levels of Syndecan-1 (CD138), in a Case of Acute Idiopathic Systemic Capillary Leak Syndrome (SCLS) (Clarkson's Disease). ( 29449526 )
2018
3
Capillary leak syndrome as a complication of antibody-mediated rejection treatment: a case report. ( 29344912 )
2018
4
Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. ( 28602874 )
2017
5
Life-threatening systemic capillary leak syndrome in juvenile dermatomyositis. ( 28957546 )
2017
6
Gemcitabine-induced chronic systemic capillary leak syndrome. ( 28855215 )
2017
7
Mimicker of hereditary angioedema: Idiopathic systemic capillary leak syndrome successfully treated with intravenous immunoglobulin. ( 28377172 )
2017
8
Capillary leak syndrome: etiologies, pathophysiology, and management. ( 28318633 )
2017
9
Clinical Presentation, Management, and Prognostic Factors of Idiopathic Systemic Capillary Leak Syndrome: A Systematic Review. ( 28939140 )
2017
10
How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis? ( 29364440 )
2017
11
Distributive Shock in the Emergency Department: Sepsis, Anaphylaxis, or Capillary Leak Syndrome? ( 28238385 )
2017
12
The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission. ( 28622216 )
2017
13
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. ( 28122158 )
2017
14
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome. ( 29097442 )
2017
15
Capillary leak syndrome in neuromyelitis optica treated with rituximab. ( 28755680 )
2017
16
Capillary Leak Syndrome Following Snakebite Envenomation. ( 29142382 )
2017
17
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. ( 28182327 )
2017
18
Rhabdomyolysis and capillary leak syndrome in a patient treated with topical imiquimod. ( 27061736 )
2016
19
Severe cerebral involvement due to idiopathic systemic capillary leak syndrome. ( 27099745 )
2016
20
Scrub typhus presenting as capillary leak syndrome. ( 27728427 )
2016
21
Idiopathic Systemic Capillary Leak Syndrome: A Case Report. ( 27195144 )
2016
22
Idiopathic systemic capillary leak syndrome (Clarkson disease). ( 28012935 )
2016
23
Subcutaneous Immunoglobulin Therapy Prevents Systemic Capillary Leak Syndrome Attack. ( 27059380 )
2016
24
Systemic capillary leak syndrome and autoimmune diseases: A case series. ( 27637319 )
2016
25
Compartment Syndrome as a Result of Systemic Capillary Leak Syndrome. ( 27688917 )
2016
26
Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate. ( 27338086 )
2016
27
A Case of Refractory Systemic Capillary Leak Syndrome (Clarkson's Disease) during Pregnancy. ( 28003676 )
2016
28
Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single-center cohort study. ( 27734564 )
2016
29
A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting. ( 27069700 )
2016
30
Sudden cardiac arrest in a 73-year-old woman caused by systemic capillary leak syndrome. ( 27056382 )
2016
31
Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. ( 27386947 )
2016
32
Fatal Primary Capillary Leak Syndrome in a Late Preterm Newborn. ( 27142601 )
2016
33
Microangiopathic Hemolytic Anemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. ( 27622772 )
2016
34
Endothelial Expression of Endothelin Receptor A in the Systemic Capillary Leak Syndrome. ( 26176954 )
2015
35
Influenza A virus infection is associated with systemic capillary leak syndrome: case report and systematic review of the literature. ( 26330157 )
2015
36
Systemic capillary leak syndrome in a patient receiving adjuvant oxaliplatin for locally advanced colon cancer. ( 26071595 )
2015
37
Interleukin-11-induced capillary leak syndrome companied with abdominal chylous leakage in primary sigmoid carcinoma patients with thrombocytopenia. ( 26881585 )
2015
38
A fatal case of acute progression of generalized edema and simultaneous flash pulmonary edema in a patient with idiopathic systemic capillary leak syndrome: a case report. ( 25928289 )
2015
39
Clinical and pathological findings of a fatal systemic capillary leak syndrome (Clarkson disease): a case report. ( 25738482 )
2015
40
1222: SUCCESSFUL MANAGEMENT OF RECURRENT IDIOPATHIC SYSTEMIC CAPILLARY LEAK SYNDROME IN A 4-YEAR OLD GIRL. ( 26570883 )
2015
41
97: PEDIATRIC SYSTEMIC CAPILLARY LEAK SYNDROME ENDOTHELIAL CELLS ARE HYPERSENSITIVE TO TNF-I9 AND LPS. ( 26569758 )
2015
42
Spinal Anesthesia in a Patient With a History of Systemic Capillary Leak Syndrome (Clarkson Disease). ( 26237002 )
2015
43
Recurrent undifferentiated shock: Idiopathic Systemic Capillary Leak Syndrome. ( 26273434 )
2015
44
In vitro Study of the Antagonistic Effect of Low-dose Liquiritigenin on Gemcitabine-induced Capillary Leak Syndrome in Pancreatic Adenocarcinoma via Inhibiting ROS- Mediated Signalling Pathways. ( 26028101 )
2015
45
Systemic Capillary Leak Syndrome after Influenza Vaccination in a Peritoneal Dialysis Patient. ( 26703855 )
2015
46
Systemic capillary leak syndrome: a case-report. ( 26117513 )
2015
47
Multiglandular hormone deficiency in a patient with systemic capillary leak syndrome. ( 25685157 )
2015
48
1197: ACUTE THERAPY WITH IVIG IN A PEDIATRIC PATIENT WITH IDIOPATHIC SYSTEMIC CAPILLARY LEAK SYNDROME. ( 26570858 )
2015
49
Clofarabine associated capillary leak syndrome in a child with lymphoma successfully treated with intravenous immunoglobulin. ( 26458636 )
2015
50
Metabolic Serum Profiles for Patients Receiving Allogeneic Stem Cell Transplantation: The Pretransplant Profile Differs for Patients with and without Posttransplant Capillary Leak Syndrome. ( 26609191 )
2015

Variations for Capillary Leak Syndrome

Expression for Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for Capillary Leak Syndrome

Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 C1S C4A CSF2 CXCL8 ELANE IL2
2
Show member pathways
12.62 C4A CXCL8 IL2 IL6
3
Show member pathways
12.32 CXCL8 IL2 IL6
4
Show member pathways
12.23 CSF2 IL2 IL6
5 12.22 CSF2 IL2 IL6
6
Show member pathways
12.16 CSF2 IL2 IL6
7
Show member pathways
12.13 ALB IL2 IL6
8
Show member pathways
12.13 CSF2 CXCL8 IL6
9 11.97 C4A CXCL8 IL6
10
Show member pathways
11.95 CXCL8 IL2 IL6
11 11.89 CSF2 CXCL8 ELANE IL6
12 11.81 CXCL8 IL2 IL6
13 11.79 CSF2 IL2 IL6
14 11.69 CSF2 CXCL8 IL6
15
Show member pathways
11.67 CSF2 CXCL8 IL6
16 11.64 CSF2 CXCL8 IL6
17 11.61 CSF2 CXCL8 IL6
18
Show member pathways
11.53 CSF2 CXCL8 IL2
19 11.5 CSF2 IL2 IL6
20 11.41 CSF2 CXCL8 IL6
21 11.37 CSF2 CXCL8 IL2 IL6
22 11.35 CXCL8 IL6
23 11.34 ELANE IL6
24 11.33 CSF2 IL6
25 11.27 CSF2 CXCL8 IL6
26
Show member pathways
11.19 CSF2 IL2
27 11.16 CXCL8 IL6
28 11.15 CSF2 CXCL8
29 11.14 C1S C4A CXCL8 IL6
30 10.91 CSF2 IL2 IL6
31 10.9 CSF2 CXCL8 IL2 IL6
32 10.87 CXCL8 IL6
33 10.8 CSF2 CXCL8 IL2 IL6
34
Show member pathways
10.72 CSF2 CXCL8 IL2 IL6

GO Terms for Capillary Leak Syndrome

Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB C4A CSF2 CXCL8 ELANE IL2
2 endoplasmic reticulum lumen GO:0005788 9.43 ALB C4A IL6
3 blood microparticle GO:0072562 9.33 ALB C1S C4A
4 extracellular region GO:0005576 9.23 ALB C1S C4A CSF2 CXCL8 ELANE

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 CSF2 CXCL8 IL2 IL6
2 regulation of receptor activity GO:0010469 9.62 CSF2 CXCL8 IL2 IL6
3 cellular protein metabolic process GO:0044267 9.58 ALB C4A IL6
4 cellular response to lipopolysaccharide GO:0071222 9.43 CSF2 CXCL8 IL6
5 positive regulation of immunoglobulin secretion GO:0051024 9.16 IL2 IL6
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 CSF2 IL2 IL6
7 negative regulation of chemokine biosynthetic process GO:0045079 8.62 ELANE IL6

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 C1S C4A ELANE
2 growth factor activity GO:0008083 9.13 CSF2 IL2 IL6
3 cytokine activity GO:0005125 8.92 CSF2 CXCL8 IL2 IL6

Sources for Capillary Leak Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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