MCID: CPL003
MIFTS: 52

Capillary Leak Syndrome malady

Cardiovascular diseases, Rare diseases, Bone diseases categories

Summaries for Capillary Leak Syndrome

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66Wikipedia, 34MalaCards
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Wikipedia:66 Capillary leak syndrome (also known as systemic capillary leak syndrome, SCLS, or Clarkson?s disease) is... more...

MalaCards: Capillary Leak Syndrome is related to psoriasis and myeloma. An important gene associated with Capillary Leak Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Selected targets of C EBPalpha. The compounds pegfilgrastim and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone marrow and bone, and related mouse phenotypes are other and tumorigenesis.

Aliases & Classifications for Capillary Leak Syndrome

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Bone diseases


Aliases & Descriptions:

capillary leak syndrome 9 11 46 63


External Ids:

Disease Ontology9 DOID:14400
NCIt41 C62578
SNOMED-CT59 87730004
MeSH36 D019559

Related Diseases for Capillary Leak Syndrome

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18GeneCards, 19GeneDecks
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Diseases in the Systemic Capillary Leak Syndrome family:

capillary leak syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.7IL8, IL2, IL6, ELANE
2myeloma30.5ALB, CSF3, IL6, IL2, CSF2
3adult respiratory distress syndrome30.3IL8, ELANE
4pancytopenia30.3CSF3, CSF2
5pancreatitis30.3IL6, C1S, ELANE, ALB
6thrombocytopenia30.1IL2, IL6, CSF2, CSF3, ALB
7sepsis29.8IL6, C3, C1S, SERPING1, ELANE, IL8
8systemic capillary leak syndrome11.2
9compartment syndrome10.7
10endotheliitis10.6
11hepatitis10.4
12influenza10.4
13brucellosis10.3
14cutaneous t cell lymphoma10.3
15leukemia10.3
16generalized pustular psoriasis10.3
17hepatitis c10.2
18polycythemia vera10.2
19status epilepticus10.2
20nasopharyngitis10.2
21hemophagocytic lymphohistiocytosis10.2
22pulmonary edema10.2
23cerebritis10.2
24anaplastic large cell lymphoma10.2
25kawasaki disease10.2
26breast cancer10.2
27diarrhea10.2
28histiocytosis10.2
29hypertension10.2
30lymphoblastic leukemia10.2
31multiple myeloma10.2
32pancreatic cancer10.2
33polycythemia10.2
34renal cell carcinoma10.2
35blindness10.2
36alk-negative anaplastic large cell lymphoma10.2
37macroglossia10.1C1S
38pustulosis palmaris et plantaris10.1ELANE
39hepatopulmonary syndrome10.1ALB
40toxic shock syndrome10.1IL2
41c1 inhibitor deficiency10.1SERPING1
42malaria10.1ALB
43common cold10.1IL8
44t-cell large granular lymphocyte leukemia10.1IL2, CSF2
45periodontitis10.1IL8
46bronchiolitis10.1IL8
47hereditary angioedema10.1SERPING1, C1S
48pulmonary sarcoidosis10.1CSF2, IL2
49ulcerative colitis10.1ALB
50angioedema10.1C1S, SERPING1

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to capillary leak syndrome

Symptoms for Capillary Leak Syndrome

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Drugs & Therapeutics for Capillary Leak Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Capillary Leak Syndrome

Drug clinical trials:

Search ClinicalTrials for Capillary Leak Syndrome

Search NIH Clinical Center for Capillary Leak Syndrome

Search CenterWatch for Capillary Leak Syndrome

Genetic Tests for Capillary Leak Syndrome

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Anatomical Context for Capillary Leak Syndrome

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34MalaCards
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MalaCards organs/tissues related to Capillary Leak Syndrome:

34
Endothelial, Bone marrow, Bone, Lung, T cells, Breast, Heart, Skeletal muscle, Small intestine, Liver, Kidney

Animal Models for Capillary Leak Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Capillary Leak Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.4CSF2, C3, IL2
2MP:00020068.3IL6, IL2, ALB, ELANE, CSF2
3MP:00053677.9C3, CSF2, CSF3, ALB, IL6
4MP:00053797.9ALB, IL2, IL6, C3, CSF2
5MP:00053977.2ELANE, CSF3, C3, IL6, IL8, IL2
6MP:00053877.2C3, IL8, CSF3, ELANE, IL2, CSF2

Publications for Capillary Leak Syndrome

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Sources:
53PubMed
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Articles related to Capillary Leak Syndrome:

(show top 50)    (show all 172)
idTitleAuthorsYear
1
Two Episodes of Systemic Capillary Leak Syndrome in an 8-year-old Boy, Following Influenza A Virus Infection. (23995592)
2014
2
An unusual cause of secondary capillary leak syndrome in a child: rotavirus diarrhea. (23692840)
2013
3
Episodic idiopathic systemic capillary leak syndrome in a girl. (23910812)
2013
4
Systemic capillary leak syndrome: recognition prevents morbidity and mortality. (24134172)
2013
5
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma. (22953081)
2012
6
The systemic capillary leak syndrome: a scarcely known nephrological entity. (22135035)
2012
7
A case of brucellosis complicated with fatal capillary leak syndrome. (22897381)
2012
8
The systemic capillary leak syndrome: a case series of 28 patients from a European registry. (21464348)
2011
9
Idiopathic systemic capillary leak syndrome preceding diagnosis of infiltrating lobular carcinoma of the breast with quiescence during neoadjuvant chemotherapy. (21364118)
2011
10
Capillary leak syndrome: initial presentation in a patient with ALK+a88anaplastic large cell lymphoma associated with increased levels of serum cytokines. (21463119)
2011
11
Pulmonary capillary leak syndrome as a result of OKT-3 therapy. (21441802)
2011
12
Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab. (20360479)
2010
13
Neurologic involvement in a child with systemic capillary leak syndrome. (20123768)
2010
14
Idiopathic systemic capillary leak syndrome (Clarkson's disease): the Mayo clinic experience. (20634497)
2010
15
A case report of systemic capillary leak syndrome (Clarkson's disease). (20148770)
2010
16
Recurrent capillary leak syndrome following bortezomib therapy in a patient with relapsed myeloma. (20150504)
2010
17
The systemic capillary leak syndrome. (21135304)
2010
18
Four-limb compartment syndrome associated with the systemic capillary leak syndrome. (21119178)
2010
19
Systemic sclerosis, capillary leak syndrome and nasopharyngeal carcinoma: an unusual association or paraneoplastic manifestations? (19052056)
2009
20
Systemic capillary leak syndrome or Clarkson's disease: a case report. (19526356)
2009
21
Chronic systemic capillary leak syndrome: a case responding to prednisolone treatment. (20166237)
2009
22
High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome. (18552679)
2008
23
Systemic capillary leak syndrome associated with compartment syndrome. (17878647)
2007
24
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
25
Severe gemcitabine-induced capillary-leak syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease. (15630853)
2004
26
Intraperitoneal photodynamic therapy causes a capillary-leak syndrome. (12794017)
2003
27
An unusual evolution of the systemic capillary leak syndrome. (11865098)
2002
28
Systemic capillary leak syndrome. (12487153)
2002
29
Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome. (11591575)
2001
30
G-CSF related capillary leak syndrome in a child with leukemia. (11911434)
2001
31
Life-threatening capillary leak syndrome after G-CSF mobilization and collection of peripheral blood progenitor cells for allogeneic transplantation. (11536001)
2001
32
Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation. (10731056)
2000
33
Hypoalbuminemia, surgical leak, and clinical capillary leak syndrome. (10636355)
2000
34
Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes. (10328196)
1999
35
Capillary leak syndrome in a patient with septicemia and granulocyte-colony-stimulating factor (G-CSF)-induced accelerated granulopoiesis. (9680943)
1998
36
Multisystem organ failure and capillary leak syndrome in severe necrotizing enterocolitis of very low birth weight infants. (9537561)
1998
37
Granulocyte-macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature. (9489640)
1998
38
Systemic capillary leak syndrome: where does the fluid go? (9799931)
1998
39
Systemic capillary leak syndrome: report on 13 patients with special focus on course and treatment. (9428835)
1997
40
Pulmonary capillary leak syndrome associated with the use of intravenous cyclosporin. (8941609)
1996
41
Systemic capillary leak syndrome in a child. (7472826)
1995
42
Biclonal SAczary syndrome with capillary leak syndrome. (8136545)
1994
43
Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation. (8110879)
1994
44
Idiopathic capillary leak syndrome complicated by massive rhabdomyolysis. (8325053)
1993
45
Control of systemic capillary leak syndrome with aminophylline and terbutaline. (1580299)
1992
46
Pulmonary capillary leak syndrome complicating generalized pustular psoriasis: possible role of cytokines. (1751356)
1991
47
Muscle biopsy findings in systemic capillary leak syndrome. (2179110)
1990
48
Systemic capillary leak syndrome. (2563486)
1989
49
Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome. (3625226)
1987
50
Capillary leak syndrome with pulmonary edema. (5035983)
1972

Variations for Capillary Leak Syndrome

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Expression for genes affiliated with Capillary Leak Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for genes affiliated with Capillary Leak Syndrome

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Sources:
51PathCards, 55R&D Systems, 13EMD Millipore, 39NCBI BioSystems Database, 31KEGG, 56Reactome, 54QIAGEN, 61Thomson Reuters, 58SinoBiological
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Pathways related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CSF2, IL2
29.8ELANE, ALB
39.6CSF2, IL8
49.3IL6, ELANE
59.3C4A, C3, C1S
6
Show member pathways
9.3C1S, C3, C4A
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.2IL2, IL8, CSF2
89.0IL6, IL8
99.0IL6, IL8
10
Show member pathways
9.0IL2, IL6, CSF2
11
Show member pathways
9.0CSF2, IL6, IL2
12
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.0IL2, IL6, CSF2
139.0IL2, IL6, CSF2
14
Show member pathways
9.0C1S, ELANE, C3, C4A
15
Show member pathways
8.9C4A, IL6, IL2
16
Show member pathways
8.9C3, IL6, IL2
178.8CSF3, CSF2, IL6
18
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.8C4A, C3, SERPING1, C1S
19
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
8.8C1S, SERPING1, C3, C4A
20
Show member pathways
8.7CSF2, IL6, IL8
218.7CSF2, IL6, IL8
228.7IL8, IL6, CSF2
238.7IL2, IL8, IL6
248.7IL2, IL8, IL6
258.7IL6, IL8, IL2
268.6C4A, IL6, IL8
278.6IL8, IL6, C3
288.5IL8, IL6, CSF3
29
Show member pathways
Type III interferon signaling39
8.5IL2, IL6, CSF2, CSF3
308.5IL2, IL6, CSF2, CSF3
318.4CSF2, IL6, IL8, ELANE
328.4IL2, IL8, IL6, CSF2
33
Show member pathways
8.2IL2, IL8, IL6, C3
34
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.2IL2, IL8, IL6, C3
35
Show member pathways
8.2CSF3, CSF2, IL6, IL8
36
Show member pathways
7.9IL2, IL8, IL6, CSF2, CSF3
37
Show member pathways
7.9CSF3, CSF2, IL6, IL8, IL2
38
Show member pathways
7.9IL2, IL8, IL6, CSF2, CSF3
39
Show member pathways
7.9IL2, IL8, IL6, CSF2, CSF3
407.4C4A, C3, IL6, IL8, SERPING1, C1S

Compounds for genes affiliated with Capillary Leak Syndrome

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1pegfilgrastim46 1210.7CSF2, ELANE, CSF3
2molgramostim469.7CSF3, IL2, CSF2
3dacarbazine46 1210.6CSF3, IL2, CSF2
4bcnu469.5CSF3, IL2, CSF2
5salmeterol46 52 30 1212.5IL2, CSF2, IL8
6zidovudine46 52 1211.3CSF2, CSF3, ALB, IL2
7pixy321469.2IL6, CSF2, CSF3
8okt3469.2CSF2, IL6, IL2
9fluticasone propionate46 52 62 1212.1ELANE, IL8, CSF2
10sivelestat469.1IL6, ELANE, IL8
11olopatadine46 1210.1IL6, CSF2, IL8
12tepoxalin469.1IL8, IL2, IL6
13n-formylmethionyl-leucylphenylalanine469.1IL8, CSF2, CSF3, ELANE
14gabexate mesilate469.1IL6, IL8, ELANE
15taurine chloramine469.1IL6, IL8, IL2
16ulinastatin469.1IL6, ELANE, IL8
17mip 1alpha469.1IL6, CSF2, IL8
18imiquimod46 62 30 1212.0CSF2, IL6, IL8
19filgrastim46 129.9CSF3, CSF2, IL6, ELANE
20fmlp468.9ELANE, IL8, CSF2, CSF3
21groalpha468.9CSF2, IL8, IL6
22il-12468.8IL8, IL6, CSF2, IL2
23aprotinin46 129.8IL6, IL8, ELANE, C1S
24triptolide468.8IL2, IL6, IL8
25il 10468.8IL6, IL8, IL2, CSF2
26protamine468.8IL2, IL6, ELANE, IL8
27etanercept46 52 1210.7C1S, IL8, IL6
28leukotriene b446 62 2510.7IL6, ELANE, CSF2, IL8
29prednisolone46 30 1210.7IL6, CSF3, ALB, IL2
30rituximab46 52 1210.6CSF3, CSF2, IL6, IL2, C1S
31calcitriol46 62 25 1211.6ALB, IL2, IL6, CSF2
32herbimycin a46 629.6IL2, IL6, IL8, CSF2
33fibrinogen468.6C1S, ELANE, ALB, IL6, C3
34pentoxifylline46 129.5CSF2, IL6, IL8, IL2, ELANE
35hydrocortisone46 3 62 1211.5IL2, IL6, ELANE, IL8, CSF2
36hyaluronic acid46 259.5CSF2, IL6, ALB, IL8, ELANE
37polyinosinic-polycytidylic acid468.4IL8, IL6, IL2
38histamine46 30 2510.3IL8, IL2, IL6, CSF2, ALB
39pge2468.3IL6, CSF2, IL8, IL2, ELANE
40rantes468.3IL6, CSF3, CSF2, IL8, IL2
41neopterin468.1ELANE, IL2, IL8, IL6, C3, CSF2
42heparin46 30 25 1211.0C1S, SERPING1, ELANE, IL8, ALB, C3
43anaphylatoxin468.0C4A, ELANE, IL6, IL8, C3, CSF2
44gm-csf46 309.0IL2, IL8, IL6, CSF2, CSF3, ELANE
45lactate468.0IL6, ALB, CSF2, ELANE, IL8, C3
46cyclosporin a46 30 6210.0CSF3, ELANE, IL2, IL8, IL6, CSF2
47cycloheximide467.9IL8, CSF3, IL2, IL6, CSF2
48endotoxin467.9C4A, CSF3, IL6, IL8, ELANE, CSF2
49serine467.8C3, IL8, IL2, C4A, ELANE, SERPING1
50dexamethasone46 52 30 1210.7CSF2, C3, CSF3, IL6, IL2, IL8

GO Terms for genes affiliated with Capillary Leak Syndrome

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17Gene Ontology
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Cellular components related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6ALB, SERPING1
2blood microparticleGO:0725628.1SERPING1, C3, ALB, C4A, C1S
3extracellular spaceGO:0056156.4SERPING1, IL2, IL8, IL6, C3, CSF2
4extracellular regionGO:0055766.0C4A, C1S, SERPING1, ELANE, IL2, IL8

Biological processes related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9CSF2, IL2
2complement activationGO:0069569.6C1S, C3, C4A
3negative regulation of chemokine biosynthetic processGO:0450799.6IL6, ELANE
4regulation of complement activationGO:0304499.5C3, C4A
5positive regulation of immunoglobulin secretionGO:0510249.5IL2, IL6
6positive regulation of smooth muscle cell proliferationGO:0486619.3IL6, ELANE
7negative regulation of neuron deathGO:19012159.3CSF3, IL6
8cellular response to lipopolysaccharideGO:0712229.3CSF3, CSF2, IL8
9complement activation, classical pathwayGO:0069589.1C4A, C3, SERPING1, C1S
10positive regulation of DNA replicationGO:0457409.1CSF2, IL6
11innate immune responseGO:0450878.9C1S, SERPING1, C3, C4A
12platelet activationGO:0301688.8ALB, IL6, SERPING1
13positive regulation of cell proliferationGO:0082848.6IL2, IL6, CSF2, CSF3
14immune responseGO:0069558.5IL2, IL8, C3, CSF2, CSF3
15inflammatory responseGO:0069548.4IL8, IL6, C3, C4A

Molecular functions related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.6C3, C4A
2growth factor activityGO:0080838.5IL2, IL6, CSF3, CSF2
3cytokine activityGO:0051258.4IL2, IL6, CSF2, CSF3
4protein bindingGO:0055156.5C1S, SERPING1, ELANE, IL8, IL6, C3

Products for genes affiliated with Capillary Leak Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Capillary Leak Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet