MCID: CPL003
MIFTS: 47

Capillary Leak Syndrome malady

Summaries for Capillary Leak Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Capillary leak syndrome (usually Systemic Capillary Leak Syndrome, SCLS or Clarkson’s Disease) is an... more...

MalaCards: Capillary Leak Syndrome is related to psoriasis and myeloma. An important gene associated with Capillary Leak Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are Rho Family GTPases and Rheumatoid arthritis. The compounds gabexate mesilate and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone marrow and bone, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Capillary Leak Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

capillary leak syndrome 8 10 44 60


External Ids:

Disease Ontology8 DOID:14400
MeSH34 D019559
SNOMED-CT56 87730004
NCIt39 C62578

Related Diseases for Capillary Leak Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Systemic Capillary Leak Syndrome family:

capillary leak syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.7IL8, IL2, ELANE, IL6
2myeloma30.5IL6, IL2, CSF3, ALB, CSF2
3leukemia30.4IL6, CSF3, CSF2, IL2
4hepatitis c30.2ALB
5hypertension30.2ALB
6kawasaki disease30.2ELANE
7diarrhea30.2ALB, IL2
8pancreatic cancer30.2IL8
9acute leukemia30.1CSF2, CSF3, IL2
10adult respiratory distress syndrome30.1IL8, ELANE
11multiple myeloma30.1CSF3, IL6
12pancreatitis30.1ELANE, C1S, IL6, ALB
13thrombocytopenia30.1CSF2, ALB, IL6, CSF3, IL2
14vascular disease30.1ELANE, C3, IL2, IL6, IL8
15systemic capillary leak syndrome10.8
16compartment syndrome10.6
17capillary disease10.6
18hepatitis10.4
19influenza10.4
20adult syndrome10.3
21brucellosis10.3
22cutaneous t cell lymphoma10.3
23syndromic diarrhea10.1
24status epilepticus10.1
25polycythemia vera10.1
26hemophagocytic lymphohistiocytosis10.1
27pulmonary edema10.1
28cerebritis10.1
29pancytopenia10.1
30nasopharyngitis10.1
31anterior compartment syndrome10.1
32anaplastic large cell lymphoma10.1
33small intestine lymphoma10.1
34breast cancer10.1
35histiocytosis10.1
36lymphoblastic leukemia10.1
37polycythemia10.1
38renal cell carcinoma10.1
39ischemia10.0C1S
40dermatitis10.0CSF2
41aspergillosis10.0ELANE
42sarcoidosis10.0IL2
43toxic shock syndrome10.0IL2
44gingivitis10.0ELANE
45leprosy10.0IL2
46malignant glioma10.0IL2
47neuropathy10.0ALB
48crohn's disease10.0ALB
49malaria10.0ALB
50hypereosinophilic syndrome10.0CSF2

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to capillary leak syndrome

Clinical Features for Capillary Leak Syndrome

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Drugs & Therapeutics for Capillary Leak Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Capillary Leak Syndrome

Drug clinical trials:

Search ClinicalTrials for Capillary Leak Syndrome

Search NIH Clinical Center for Capillary Leak Syndrome

Search CenterWatch for Capillary Leak Syndrome

Genetic Tests for Capillary Leak Syndrome

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Anatomical Context for Capillary Leak Syndrome

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32MalaCards
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MalaCards organs/tissues related to Capillary Leak Syndrome:

32
Endothelial, Bone marrow, Bone, Lung, T cells, Breast, Heart, Skeletal muscle, Small intestine, Liver, Kidney

Animal Models for Capillary Leak Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Capillary Leak Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1C3
2MP:00020068.8IL6, IL2, ALB, ELANE
3MP:00053977.5ELANE, C3, IL2, IL6, IL8, CSF3
4MP:00053877.2CSF2, CSF3, IL8, IL6, IL2, C3

Publications for Capillary Leak Syndrome

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Sources:
50PubMed
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Articles related to Capillary Leak Syndrome:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
Two Episodes of Systemic Capillary Leak Syndrome in an 8-year-old Boy, Following Influenza A Virus Infection. (23995592)
2014
2
Trastuzumab-Induced Systemic Capillary Leak Syndrome in a Breast Cancer Patient. (24163290)
2013
3
Severe capillary leak syndrome after inner ear decompression sickness in a recreational scuba diver. (23602149)
2013
4
Secondary capillary leak syndrome related to pemetrexed exposure. (22444494)
2012
5
What dose of intravenous immunoglobulin should be administered in Kawasaki disease with suspected systemic capillary leak syndrome? Comment on: shock: an unusual presentation of Kawasaki disease (Eur J Pediatr. 2011 Jul; 170(7):941-3). (22037757)
2012
6
Capillary leak syndrome and abdominal compartment syndrome from occult rectal malignancy. (23089411)
2012
7
Capillary leak syndrome: initial presentation in a patient with ALK+a88anaplastic large cell lymphoma associated with increased levels of serum cytokines. (21463119)
2011
8
Pulmonary capillary leak syndrome as a result of OKT-3 therapy. (21441802)
2011
9
Systemic capillary leak syndrome caused by granulocyte colony-stimulating factor. (21963759)
2011
10
Compartment syndrome in all four extremities: a rare case associated with systemic capillary leak syndrome. (22379451)
2011
11
Systemic capillary leak syndrome. (21738986)
2011
12
Pulmonary capillary leak syndrome following influenza A (H1N1) virus infection in pregnant and postpartum women. (21672553)
2011
13
Four-limb compartment syndrome associated with the systemic capillary leak syndrome. (21119178)
2010
14
Impedance cardiography in the diagnosis of capillary leak syndrome caused by doxorubicin therapy in a patient with myeloma multiplex. (20104463)
2010
15
Clofarabine-induced capillary leak syndrome in a child with refractory acute lymphoblastic leukemia. (20057324)
2010
16
Systemic capillary leak syndrome should be considered in the differential diagnosis of multi-organ failure and hypovolemic shock. (20508484)
2010
17
Systemic capillary leak syndrome or Clarkson's disease: a case report. (19526356)
2009
18
Abdominal compartment syndrome associated with capillary leak syndrome after liver transplantation. (19917414)
2009
19
Systemic capillary leak syndrome resulting in compartment syndrome and the requirement for a surgical airway. (19453323)
2009
20
Systemic capillary leak syndrome associated with compartment syndrome. (17878647)
2007
21
Capillary leak syndrome in a 5-month-old infant associated with intractable diarrhoea. (17469737)
2007
22
Validation of C1-esterase inhibitor therapy in severe capillary leak syndrome by monitoring of extravascular lung water. (14727019)
2004
23
Capillary leak syndrome induced by acitretin. (14746632)
2004
24
Systemic capillary leak syndrome. (12487153)
2002
25
Plasma vascular endothelial growth factor level is a predictor of the severity of postoperative capillary leak syndrome in neonates undergoing cardiopulmonary bypass. (11793065)
2002
26
Capillary leak syndrome after interferon treatment for chronic hepatitis C. (11863486)
2002
27
G-CSF related capillary leak syndrome in a child with leukemia. (11911434)
2001
28
Capillary leak syndrome in children who undergo cardiopulmonary bypass: clinical outcome in comparison with complement activation and C1 inhibitor. (11280634)
2001
29
Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation. (10731056)
2000
30
Systemic capillary leak syndrome]. (10682651)
2000
31
Chronic systemic capillary leak syndrome. Report of a case and review of the literature. (10886496)
2000
32
Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes. (10328196)
1999
33
Acute reversible cardiac involvement associated with systemic capillary leak syndrome. (10229177)
1999
34
Lethal capillary leak syndrome after a single administration of interferon beta-1b. (10408566)
1999
35
Multisystem organ failure and capillary leak syndrome in severe necrotizing enterocolitis of very low birth weight infants. (9537561)
1998
36
Granulocyte-macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature. (9489640)
1998
37
Pulmonary capillary leak syndrome associated with the use of intravenous cyclosporin. (8941609)
1996
38
Transcapillary forces of the subcutaneous tissue in patients treated with interleukin-2 and alpha-interferon: no capillary protein leak syndrome? (9414399)
1996
39
NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, ameliorates interleukin-2-induced capillary leak syndrome in healthy mice. (8680649)
1995
40
Levels of the terminal complement complex, C3a-desArg and C1-inhibitor in adult patients with capillary leak syndrome following bone marrow transplantation. (8534757)
1995
41
Idiopathic capillary leak syndrome complicated by massive rhabdomyolysis. (8325053)
1993
42
C1-inhibitor concentrate for sepsis-related capillary leak syndrome. (1348818)
1992
43
Pulmonary capillary leak syndrome complicating generalized pustular psoriasis: possible role of cytokines. (1751356)
1991
44
The systemic capillary leak syndrome: appearance of interleukin-2-receptor-positive cells during attacks. (2386338)
1990
45
Treatment of systemic capillary leak syndrome. (2904614)
1988
46
Epoprostenol in systemic capillary leak syndrome. (2903357)
1988
47
Lymphokine activated killer (LAK) cell-mediated endothelial injury: a mechanism for capillary leak syndrome in patients treated with LAK cells and interleukin-2. (3502662)
1987
48
Disappearance of pulmonary capillary leak syndrome when intravenous cyclosporine is replaced by oral cyclosporine. (3554668)
1987
49
Postpartum capillary leak syndrome. A case report. (7428393)
1980
50
Capillary leak syndrome with massive intestinal edema after appendectomy. (4832143)
1974

Genetic Variations for Capillary Leak Syndrome

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Expression for genes affiliated with Capillary Leak Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Leak Syndrome

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Pathways for genes affiliated with Capillary Leak Syndrome

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51QIAGEN, 29KEGG, 52R&D Systems, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 55SinoBiological
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Pathways related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CSF2
210.2CSF2
310.1C3
4
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9.9IL2, CSF2
59.7C4A, C3
6
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9.7CSF2, CSF3
7
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9.7CSF3, CSF2
89.5IL2, IL6
99.4C3, C4A, C1S
10
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9.4CSF2, IL8, IL2
11
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9.2CSF2, IL6, IL2
129.0IL6, IL8, CSF2
139.0IL6, IL8, CSF2
149.0CSF2, CSF3, IL6
159.0IL8, IL6, IL2
169.0IL2, IL6, IL8
17
Immune response Lectin induced complement pathway
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9.0C3, SERPING1, C4A, C1S
18
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9.0C1S, C4A, SERPING1, C3
19
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9.0C1S, C4A, SERPING1, C3
209.0C4A, IL8, IL6
218.9C3, IL6, IL8
228.7ELANE, IL6, IL8, CSF2
238.7CSF2, IL8, IL6, IL2
248.7CSF2, CSF3, IL6, IL2
25
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8.6IL8, IL6, IL2, C3
26
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8.6C3, IL2, IL6, IL8
27
Cytokine production by Th17 cells in CF (Mouse model)
8.5CSF2, CSF3, IL8, IL6
28
Hide members
8.2CSF2, CSF3, IL8, IL6, IL2
297.8C3, SERPING1, IL6, IL8, C4A, C1S
30
Hide members
7.8C1S, CSF2, C4A, POLR3G, IL6, IL2

Compounds for genes affiliated with Capillary Leak Syndrome

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1gabexate mesilate4410.6ELANE
2ulinastatin4410.6ELANE
3sivelestat sodium hydrate4410.4ELANE
4pentoxifylline44 1111.3CSF2, ELANE
5pge24410.1CSF2, IL2
6hydrocortisone44 2 59 1113.1IL8, ELANE
7cyclosporin a44 28 5912.1ELANE, CSF3
8endotoxin4410.0CSF3, C4A
9pegfilgrastim44 1110.8ELANE, CSF3, CSF2
10romurtide449.8CSF2, CSF3
11molgramostim449.8CSF2, CSF3, IL2
12dexamethasone44 49 28 1112.8IL6, C3
13aprotinin44 1110.8IL8, ELANE, C1S
14salmeterol44 49 28 1112.7CSF2, IL8, IL2
15dacarbazine44 1110.7CSF3, IL2, CSF2
16bcnu449.7IL2, CSF3, CSF2
17fmlp449.6ELANE, CSF3, CSF2
18fluticasone propionate44 49 59 1112.6ELANE, IL8, CSF2
19okt3449.5IL6, IL2, CSF2
20emedastine44 1110.5IL8, IL6
21sivelestat449.5IL8, IL6, ELANE
22anaphylatoxin449.4IL8, ELANE, C4A, CSF2
23pixy321449.4IL6, CSF3, CSF2
24tepoxalin449.4IL6, IL2, IL8
25olopatadine44 1110.4IL6, IL8, CSF2
26mip 1alpha449.4IL8, CSF2, IL6
27taurine chloramine449.4IL2, IL8, IL6
28zidovudine44 1110.4ALB, IL2, CSF3, CSF2
29imiquimod44 28 59 1112.4IL6, IL8, CSF2
30groalpha449.3CSF2, IL8, IL6
31mycophenolate mofetil44 49 1111.3IL2, CSF3, ALB
32n-formylmethionyl-leucylphenylalanine449.3CSF3, ELANE, IL8, CSF2
33triptolide449.3IL6, IL8, IL2
34filgrastim44 1110.2CSF2, ELANE, IL6, CSF3
35il-12449.2IL2, CSF2, IL6, IL8
36il 10449.1IL2, IL6, IL8, CSF2
37rantes449.1CSF2, IL2, IL6, CSF3
38leukotriene b444 59 2411.1ELANE, IL6, IL8, CSF2
39polyinosinic-polycytidylic acid449.1IL6, IL8, IL2
40etanercept44 49 1111.1IL6, IL8, C1S
41herbimycin a44 5910.0IL2, IL6, IL8, CSF2
42rituximab44 49 1110.9C1S, CSF2, IL2, IL6, CSF3
43fibrinogen448.9ALB, IL6, C1S, C3, ELANE
44hyaluronic acid44 249.8ALB, IL6, IL8, CSF2, ELANE
45calcitriol44 59 11 2411.8ALB, IL6, CSF2, IL2
46serine448.8SERPING1, IL8, C3
47histamine44 28 2410.7IL6, ALB, CSF2, IL8, IL2
48heparin44 28 11 2411.7IL8, ELANE, C1S, CSF2, C3, SERPING1
49neopterin448.5IL6, CSF2, IL2, C3, ELANE, IL8
50lactate448.4ELANE, IL6, IL8, CSF2, C3, ALB

GO Terms for genes affiliated with Capillary Leak Syndrome

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16Gene Ontology
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Cellular components related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.6CSF2, C4A, IL8, IL6, IL2, SERPING1
2extracellular spaceGO:0056156.3ALB, CSF2, CSF3, C4A, IL8, IL6

Biological processes related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:0450799.8IL6, ELANE
2regulation of complement activationGO:0304499.7C3, C4A
3complement activationGO:0069569.6C3, C4A, C1S
4positive regulation of immunoglobulin secretionGO:0510249.6IL2, IL6
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6IL2, CSF2
6negative regulation of neuron deathGO:19012159.4IL6, CSF3
7cellular response to lipopolysaccharideGO:0712229.3CSF2, CSF3, IL8
8complement activation, classical pathwayGO:0069589.2C3, SERPING1, C4A, C1S
9immune responseGO:0069558.7CSF2, CSF3, IL8, IL2, C3
10positive regulation of cell proliferationGO:0082848.6CSF2, CSF3, IL6, IL2
11inflammatory responseGO:0069548.6C4A, IL8, IL6, C3
12innate immune responseGO:0450878.3C1S, C4A, POLR3G, SERPING1, C3

Molecular functions related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7IL2, IL6, CSF3, CSF2
2growth factor activityGO:0080838.4IL2, IL6, CSF3, CSF2

Products for genes affiliated with Capillary Leak Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Capillary Leak Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet