MCID: CPL003
MIFTS: 45

Capillary Leak Syndrome malady

Rare diseases, Bone diseases categories

Aliases & Classifications for Capillary Leak Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH
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Capillary Leak Syndrome, Aliases & Descriptions:

Name: Capillary Leak Syndrome 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:14400
NCIt38 C62578
SNOMED-CT55 87730004
MeSH33 D019559

Summaries for Capillary Leak Syndrome

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Wikipedia:63 Capillary leak syndrome (also known as systemic capillary leak syndrome, SCLS, or Clarkson?s disease) is... more...

MalaCards based summary: Capillary Leak Syndrome is related to c1 inhibitor deficiency and psoriasis. An important gene associated with Capillary Leak Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Selected targets of C EBPalpha. The compounds pegfilgrastim and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone marrow and bone, and related mouse phenotypes are other and tumorigenesis.

Related Diseases for Capillary Leak Syndrome

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Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1c1 inhibitor deficiency30.9SERPING1
2psoriasis30.6ELANE, IL2, IL8, IL6
3pancytopenia30.5CSF2, CSF3
4pancreatitis30.3C1S, ELANE, IL6, ALB
5myeloma30.1ALB, CSF3, CSF2, IL6, IL2
6thrombocytopenia29.8IL2, IL6, CSF2, CSF3, ALB
7systemic capillary leak syndrome11.2
8compartment syndrome10.7
9endotheliitis10.6
10macroglossia10.5C1S
11pustulosis palmaris et plantaris10.5ELANE
12hepatopulmonary syndrome10.5ALB
13toxic shock syndrome10.5IL2
14malaria10.4ALB
15hepatitis10.4
16influenza10.4
17common cold10.4IL8
18t-cell large granular lymphocyte leukemia10.4CSF2, IL2
19periodontitis10.4IL8
20leukemia10.3
21brucellosis10.3
22cutaneous t cell lymphoma10.3
23bronchiolitis10.3IL8
24angioedema, hereditary, types i and ii10.3C1S, SERPING1
25pulmonary sarcoidosis10.3IL2, CSF2
26ulcerative colitis10.3ALB
27angioedema10.3C1S, SERPING1
28acute kidney failure10.3C1S, ALB
29acute respiratory distress syndrome10.2ELANE, IL8
30bronchopulmonary dysplasia10.2ELANE, IL8
31extrinsic allergic alveolitis10.2ELANE, IL8
32tetanus10.2IL2, CSF2, ALB
33pulmonary tuberculosis10.2C3, IL2
34bronchiectasis10.2ELANE, IL8
35alcoholic hepatitis10.2IL8, ALB
36bronchitis10.2IL8, ELANE
37mastitis10.2IL8, ALB
38periodontal disease10.2IL6, ELANE
39urticaria10.2C1S, SERPING1
40complement deficiency10.2C4A, C3, C1S
41alcoholic liver cirrhosis10.2IL8, ALB
42colorectal cancer10.2
43breast cancer10.2
44polycythemia vera10.2
45aspergillosis10.2
46nasopharyngeal carcinoma10.2
47pancreatic cancer10.2
48kawasaki disease10.2
49renal cell carcinoma10.2
50multiple myeloma10.2

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to capillary leak syndrome

Symptoms for Capillary Leak Syndrome

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Drugs & Therapeutics for Capillary Leak Syndrome

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Drug clinical trials:

Search ClinicalTrials for Capillary Leak Syndrome

Search NIH Clinical Center for Capillary Leak Syndrome

Genetic Tests for Capillary Leak Syndrome

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Anatomical Context for Capillary Leak Syndrome

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MalaCards organs/tissues related to Capillary Leak Syndrome:

31
Endothelial, Bone marrow, Bone, Lung, T cells, Breast, Heart, Skeletal muscle, Small intestine, Kidney, Liver, B cells

Animal Models for Capillary Leak Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Capillary Leak Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.4CSF2, C3, IL2
2MP:00020068.3IL6, IL2, ALB, ELANE, CSF2
3MP:00053677.9C3, CSF2, CSF3, ALB, IL6
4MP:00053797.9ALB, IL2, IL6, C3, CSF2
5MP:00053977.2ELANE, CSF3, C3, IL6, IL8, IL2
6MP:00053877.2C3, IL8, CSF3, ELANE, IL2, CSF2

Publications for Capillary Leak Syndrome

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Articles related to Capillary Leak Syndrome:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Multiglandular hormone deficiency in a patient with systemic capillary leak syndrome. (25685157)
2015
2
Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome. (24859554)
2014
3
Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease). (25405070)
2014
4
Clarkson disease - systemic capillary leak syndrome in a 6-year-old girl: case report. (25311880)
2014
5
Intravenous immunoglobulin in systemic capillary leak syndrome: a case report and review of literature. (24490827)
2014
6
Systemic capillary leak syndrome associated with a rare abdominal and four-limb compartment syndrome: a case report. (24934689)
2014
7
An unusual cause of secondary capillary leak syndrome in a child: rotavirus diarrhea. (23692840)
2013
8
Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease). (24808988)
2013
9
Episodic idiopathic systemic capillary leak syndrome in a girl. (23910812)
2013
10
Systemic capillary leak syndrome: recognition prevents morbidity and mortality. (24134172)
2013
11
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma. (22953081)
2012
12
The systemic capillary leak syndrome: a scarcely known nephrological entity. (22135035)
2012
13
A case of brucellosis complicated with fatal capillary leak syndrome. (22897381)
2012
14
The systemic capillary leak syndrome: a case series of 28 patients from a European registry. (21464348)
2011
15
Idiopathic systemic capillary leak syndrome preceding diagnosis of infiltrating lobular carcinoma of the breast with quiescence during neoadjuvant chemotherapy. (21364118)
2011
16
Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab. (20360479)
2010
17
Neurologic involvement in a child with systemic capillary leak syndrome. (20123768)
2010
18
Idiopathic systemic capillary leak syndrome (Clarkson's disease): the Mayo clinic experience. (20634497)
2010
19
A case report of systemic capillary leak syndrome (Clarkson's disease). (20148770)
2010
20
Recurrent capillary leak syndrome following bortezomib therapy in a patient with relapsed myeloma. (20150504)
2010
21
The systemic capillary leak syndrome. (21135304)
2010
22
Systemic sclerosis, capillary leak syndrome and nasopharyngeal carcinoma: an unusual association or paraneoplastic manifestations? (19052056)
2009
23
Systemic capillary leak syndrome or Clarkson's disease: a case report. (19526356)
2009
24
Chronic systemic capillary leak syndrome: a case responding to prednisolone treatment. (20166237)
2009
25
High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome. (18552679)
2008
26
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
27
Severe gemcitabine-induced capillary-leak syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease. (15630853)
2004
28
Intraperitoneal photodynamic therapy causes a capillary-leak syndrome. (12794017)
2003
29
An unusual evolution of the systemic capillary leak syndrome. (11865098)
2002
30
Systemic capillary leak syndrome. (12487153)
2002
31
Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome. (11591575)
2001
32
G-CSF related capillary leak syndrome in a child with leukemia. (11911434)
2001
33
Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation. (10731056)
2000
34
Hypoalbuminemia, surgical leak, and clinical capillary leak syndrome. (10636355)
2000
35
Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes. (10328196)
1999
36
Capillary leak syndrome in a patient with septicemia and granulocyte-colony-stimulating factor (G-CSF)-induced accelerated granulopoiesis. (9680943)
1998
37
Multisystem organ failure and capillary leak syndrome in severe necrotizing enterocolitis of very low birth weight infants. (9537561)
1998
38
Granulocyte-macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature. (9489640)
1998
39
Systemic capillary leak syndrome: where does the fluid go? (9799931)
1998
40
Systemic capillary leak syndrome: report on 13 patients with special focus on course and treatment. (9428835)
1997
41
Pulmonary capillary leak syndrome associated with the use of intravenous cyclosporin. (8941609)
1996
42
Biclonal SAczary syndrome with capillary leak syndrome. (8136545)
1994
43
Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation. (8110879)
1994
44
Idiopathic capillary leak syndrome complicated by massive rhabdomyolysis. (8325053)
1993
45
Control of systemic capillary leak syndrome with aminophylline and terbutaline. (1580299)
1992
46
Pulmonary capillary leak syndrome complicating generalized pustular psoriasis: possible role of cytokines. (1751356)
1991
47
Muscle biopsy findings in systemic capillary leak syndrome. (2179110)
1990
48
Systemic capillary leak syndrome. (2563486)
1989
49
Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome. (3625226)
1987
50
Capillary leak syndrome with pulmonary edema. (5035983)
1972

Variations for Capillary Leak Syndrome

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Expression for genes affiliated with Capillary Leak Syndrome

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Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for genes affiliated with Capillary Leak Syndrome

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Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CSF2, IL2
29.6IL8, CSF2
39.3ELANE, IL6
4
Show member pathways
9.3C4A, C3, C1S
59.3C1S, C3, C4A
6
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.2IL8, IL2, CSF2
79.0IL8, IL6
89.0IL6, IL8
9
Show member pathways
9.0CSF2, IL6, IL2
10
Show member pathways
9.0IL2, IL6, CSF2
11
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.0IL2, CSF2, IL6
129.0IL2, IL6, CSF2
13
Show member pathways
9.0C4A, ELANE, C1S, C3
14
Show member pathways
8.9IL2, IL6, C4A
15
Show member pathways
8.9IL6, C3, IL2
168.8IL6, CSF3, CSF2
17
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.8C1S, C3, SERPING1, C4A
18
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
8.8C1S, SERPING1, C3, C4A
19
Show member pathways
8.7IL6, IL8, CSF2
208.7IL8, IL6, CSF2
218.7IL6, IL8, CSF2
228.7IL2, IL6, IL8
238.7IL2, IL8, IL6
248.7IL6, IL8, IL2
258.6C4A, IL6, IL8
268.6C3, IL6, IL8
278.5IL8, CSF3, IL6
28
Show member pathways
Type III interferon signaling36
8.5CSF2, IL2, CSF3, IL6
298.5IL6, CSF3, IL2, CSF2
308.4ELANE, IL8, IL6, CSF2
318.4IL8, IL2, CSF2, IL6
32
Show member pathways
8.2C3, IL2, IL6, IL8
33
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.2C3, IL2, IL6, IL8
34
Show member pathways
8.2IL8, CSF3, CSF2, IL6
35
Show member pathways
7.9CSF2, CSF3, IL6, IL8, IL2
36
Show member pathways
7.9IL6, IL2, IL8, CSF2, CSF3
37
Show member pathways
7.9IL2, CSF2, IL8, IL6, CSF3
38
Show member pathways
7.9CSF3, IL6, IL8, IL2, CSF2
397.4C1S, IL6, C4A, C3, IL8, SERPING1

Compounds for genes affiliated with Capillary Leak Syndrome

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Compounds related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1pegfilgrastim43 1210.7CSF2, ELANE, CSF3
2molgramostim439.7CSF3, IL2, CSF2
3dacarbazine43 1210.6CSF3, IL2, CSF2
4bcnu439.5CSF3, IL2, CSF2
5salmeterol43 49 28 1212.5IL2, CSF2, IL8
6zidovudine43 49 1211.3CSF2, CSF3, ALB, IL2
7pixy321439.2IL6, CSF2, CSF3
8okt3439.2CSF2, IL6, IL2
9fluticasone propionate43 49 59 1212.1ELANE, IL8, CSF2
10sivelestat439.1IL6, ELANE, IL8
11olopatadine43 1210.1IL6, CSF2, IL8
12tepoxalin439.1IL8, IL2, IL6
13n-formylmethionyl-leucylphenylalanine439.1IL8, CSF2, CSF3, ELANE
14gabexate mesilate439.1IL6, IL8, ELANE
15taurine chloramine439.1IL6, IL8, IL2
16ulinastatin439.1IL6, ELANE, IL8
17mip 1alpha439.1IL6, CSF2, IL8
18imiquimod43 59 28 1212.0CSF2, IL6, IL8
19filgrastim43 129.9CSF3, CSF2, IL6, ELANE
20fmlp438.9ELANE, IL8, CSF2, CSF3
21groalpha438.9CSF2, IL8, IL6
22il-12438.8IL8, IL6, CSF2, IL2
23aprotinin43 129.8IL6, IL8, ELANE, C1S
24triptolide438.8IL2, IL6, IL8
25il 10438.8IL6, IL8, IL2, CSF2
26protamine438.8IL2, IL6, ELANE, IL8
27etanercept43 49 1210.7C1S, IL8, IL6
28leukotriene b443 59 2410.7IL6, ELANE, CSF2, IL8
29prednisolone43 28 1210.7IL6, CSF3, ALB, IL2
30rituximab43 49 1210.6CSF3, CSF2, IL6, IL2, C1S
31calcitriol43 59 24 1211.6ALB, IL2, IL6, CSF2
32herbimycin a43 599.6IL2, IL6, IL8, CSF2
33fibrinogen438.6C1S, ELANE, ALB, IL6, C3
34pentoxifylline43 129.5CSF2, IL6, IL8, IL2, ELANE
35hydrocortisone43 2 59 1211.5IL2, IL6, ELANE, IL8, CSF2
36hyaluronic acid43 249.5CSF2, IL6, ALB, IL8, ELANE
37polyinosinic-polycytidylic acid438.4IL8, IL6, IL2
38histamine43 28 2410.3IL8, IL2, IL6, CSF2, ALB
39pge2438.3IL6, CSF2, IL8, IL2, ELANE
40rantes438.3IL6, CSF3, CSF2, IL8, IL2
41neopterin438.1ELANE, IL2, IL8, IL6, C3, CSF2
42heparin43 28 24 1211.0C1S, SERPING1, ELANE, IL8, ALB, C3
43anaphylatoxin438.0C4A, ELANE, IL6, IL8, C3, CSF2
44gm-csf43 289.0IL2, IL8, IL6, CSF2, CSF3, ELANE
45lactate438.0IL6, ALB, CSF2, ELANE, IL8, C3
46cyclosporin a43 28 5910.0CSF3, ELANE, IL2, IL8, IL6, CSF2
47cycloheximide437.9IL8, CSF3, IL2, IL6, CSF2
48endotoxin437.9C4A, CSF3, IL6, IL8, ELANE, CSF2
49serine437.8C3, IL8, IL2, C4A, ELANE, SERPING1
50dexamethasone43 49 28 1210.7CSF2, C3, CSF3, IL6, IL2, IL8

GO Terms for genes affiliated with Capillary Leak Syndrome

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Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, SERPING1
2blood microparticleGO:00725628.1SERPING1, C3, ALB, C4A, C1S
3extracellular spaceGO:00056156.4SERPING1, IL2, IL8, IL6, C3, CSF2
4extracellular regionGO:00055766.0C4A, C1S, SERPING1, ELANE, IL2, IL8

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9CSF2, IL2
2complement activationGO:00069569.6C1S, C3, C4A
3negative regulation of chemokine biosynthetic processGO:00450799.6IL6, ELANE
4regulation of complement activationGO:00304499.5C3, C4A
5positive regulation of immunoglobulin secretionGO:00510249.5IL2, IL6
6positive regulation of smooth muscle cell proliferationGO:00486619.3IL6, ELANE
7negative regulation of neuron deathGO:019012159.3CSF3, IL6
8cellular response to lipopolysaccharideGO:00712229.3CSF3, CSF2, IL8
9complement activation, classical pathwayGO:00069589.1C4A, C3, SERPING1, C1S
10positive regulation of DNA replicationGO:00457409.1CSF2, IL6
11innate immune responseGO:00450878.9C1S, SERPING1, C3, C4A
12platelet activationGO:00301688.8ALB, IL6, SERPING1
13positive regulation of cell proliferationGO:00082848.6IL2, IL6, CSF2, CSF3
14immune responseGO:00069558.5IL2, IL8, C3, CSF2, CSF3
15inflammatory responseGO:00069548.4IL8, IL6, C3, C4A

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.6C4A, C3
2growth factor activityGO:00080838.5CSF3, CSF2, IL6, IL2
3cytokine activityGO:00051258.4IL2, IL6, CSF2, CSF3
4protein bindingGO:00055156.5C1S, SERPING1, ELANE, IL8, IL6, C3

Products for genes affiliated with Capillary Leak Syndrome

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Sources for Capillary Leak Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet