MCID: CPL003
MIFTS: 51

Capillary Leak Syndrome malady

Rare diseases, Bone diseases categories

Summaries for Capillary Leak Syndrome

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Wikipedia:65 Capillary leak syndrome (also known as systemic capillary leak syndrome, SCLS, or Clarkson?s disease) is... more...

MalaCards based summary: Capillary Leak Syndrome is related to psoriasis and myeloma. An important gene associated with Capillary Leak Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Selected targets of C EBPalpha. The compounds pegfilgrastim and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone marrow and bone, and related mouse phenotypes are other and tumorigenesis.

Aliases & Classifications for Capillary Leak Syndrome

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Capillary Leak Syndrome, Aliases & Descriptions:

Name: Capillary Leak Syndrome 10 12 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology10 DOID:14400
NCIt40 C62578
SNOMED-CT57 87730004
MeSH35 D019559

Related Diseases for Capillary Leak Syndrome

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Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.8IL8, IL2, IL6, ELANE
2myeloma30.6ALB, CSF3, IL6, IL2, CSF2
3c1 inhibitor deficiency30.3SERPING1
4pancytopenia30.3CSF3, CSF2
5pancreatitis30.3IL6, C1S, ELANE, ALB
6thrombocytopenia30.2IL2, IL6, CSF2, CSF3, ALB
7systemic capillary leak syndrome11.2
8compartment syndrome10.7
9endotheliitis10.6
10hepatitis10.4
11influenza10.4
12leukemia10.3
13brucellosis10.3
14cutaneous t cell lymphoma10.3
15colorectal cancer10.2
16breast cancer10.2
17polycythemia vera10.2
18aspergillosis10.2
19nasopharyngeal carcinoma10.2
20pancreatic cancer10.2
21kawasaki disease10.2
22renal cell carcinoma10.2
23multiple myeloma10.2
24pulmonary hypertension10.2
25adult respiratory distress syndrome10.2
26anaplastic large cell lymphoma10.2
27b-cell lymphomas10.2
28diffuse large b-cell lymphoma10.2
29hemophagocytic lymphohistiocytosis10.2
30hepatitis c10.2
31status epilepticus10.2
32nasopharyngitis10.2
33pulmonary edema10.2
34cerebritis10.2
35dermatomyositis10.2
36diarrhea10.2
37histiocytosis10.2
38lymphoblastic leukemia10.2
39polycythemia10.2
40blindness10.2
41alk-negative anaplastic large cell lymphoma10.2
42macroglossia10.1C1S
43pustulosis palmaris et plantaris10.1ELANE
44hepatopulmonary syndrome10.1ALB
45toxic shock syndrome10.1IL2
46malaria10.0ALB
47common cold10.0IL8
48t-cell large granular lymphocyte leukemia10.0IL2, CSF2
49periodontitis10.0IL8
50bronchiolitis10.0IL8

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to capillary leak syndrome

Symptoms for Capillary Leak Syndrome

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Drugs & Therapeutics for Capillary Leak Syndrome

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Drug clinical trials:

Search ClinicalTrials for Capillary Leak Syndrome

Search NIH Clinical Center for Capillary Leak Syndrome

Genetic Tests for Capillary Leak Syndrome

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Anatomical Context for Capillary Leak Syndrome

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MalaCards organs/tissues related to Capillary Leak Syndrome:

33
Endothelial, Bone marrow, Bone, Lung, T cells, Breast, Heart, Skeletal muscle, Small intestine, Kidney, Liver, B cells

Animal Models for Capillary Leak Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Capillary Leak Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.4CSF2, C3, IL2
2MP:00020068.3ELANE, IL2, IL6, CSF2, ALB
3MP:00053677.9ALB, CSF3, CSF2, C3, IL6
4MP:00053797.9IL2, IL6, C3, CSF2, ALB
5MP:00053977.2CSF3, ELANE, IL2, IL8, IL6, C3
6MP:00053877.2ELANE, IL2, IL8, IL6, C3, CSF2

Publications for Capillary Leak Syndrome

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Articles related to Capillary Leak Syndrome:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Multiglandular hormone deficiency in a patient with systemic capillary leak syndrome. (25685157)
2015
2
Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome. (24859554)
2014
3
Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease). (25405070)
2014
4
Clarkson disease - systemic capillary leak syndrome in a 6-year-old girl: case report. (25311880)
2014
5
Intravenous immunoglobulin in systemic capillary leak syndrome: a case report and review of literature. (24490827)
2014
6
Systemic capillary leak syndrome associated with a rare abdominal and four-limb compartment syndrome: a case report. (24934689)
2014
7
An unusual cause of secondary capillary leak syndrome in a child: rotavirus diarrhea. (23692840)
2013
8
Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease). (24808988)
2013
9
Episodic idiopathic systemic capillary leak syndrome in a girl. (23910812)
2013
10
Systemic capillary leak syndrome: recognition prevents morbidity and mortality. (24134172)
2013
11
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma. (22953081)
2012
12
The systemic capillary leak syndrome: a scarcely known nephrological entity. (22135035)
2012
13
A case of brucellosis complicated with fatal capillary leak syndrome. (22897381)
2012
14
The systemic capillary leak syndrome: a case series of 28 patients from a European registry. (21464348)
2011
15
Idiopathic systemic capillary leak syndrome preceding diagnosis of infiltrating lobular carcinoma of the breast with quiescence during neoadjuvant chemotherapy. (21364118)
2011
16
Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab. (20360479)
2010
17
Neurologic involvement in a child with systemic capillary leak syndrome. (20123768)
2010
18
Idiopathic systemic capillary leak syndrome (Clarkson's disease): the Mayo clinic experience. (20634497)
2010
19
A case report of systemic capillary leak syndrome (Clarkson's disease). (20148770)
2010
20
Recurrent capillary leak syndrome following bortezomib therapy in a patient with relapsed myeloma. (20150504)
2010
21
The systemic capillary leak syndrome. (21135304)
2010
22
Systemic sclerosis, capillary leak syndrome and nasopharyngeal carcinoma: an unusual association or paraneoplastic manifestations? (19052056)
2009
23
Systemic capillary leak syndrome or Clarkson's disease: a case report. (19526356)
2009
24
Chronic systemic capillary leak syndrome: a case responding to prednisolone treatment. (20166237)
2009
25
High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome. (18552679)
2008
26
Systemic capillary leak syndrome associated with compartment syndrome and rhabdomyolysis. (16802499)
2006
27
Severe gemcitabine-induced capillary-leak syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease. (15630853)
2004
28
Intraperitoneal photodynamic therapy causes a capillary-leak syndrome. (12794017)
2003
29
An unusual evolution of the systemic capillary leak syndrome. (11865098)
2002
30
Systemic capillary leak syndrome. (12487153)
2002
31
Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome. (11591575)
2001
32
G-CSF related capillary leak syndrome in a child with leukemia. (11911434)
2001
33
Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation. (10731056)
2000
34
Hypoalbuminemia, surgical leak, and clinical capillary leak syndrome. (10636355)
2000
35
Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes. (10328196)
1999
36
Capillary leak syndrome in a patient with septicemia and granulocyte-colony-stimulating factor (G-CSF)-induced accelerated granulopoiesis. (9680943)
1998
37
Multisystem organ failure and capillary leak syndrome in severe necrotizing enterocolitis of very low birth weight infants. (9537561)
1998
38
Granulocyte-macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature. (9489640)
1998
39
Systemic capillary leak syndrome: where does the fluid go? (9799931)
1998
40
Systemic capillary leak syndrome: report on 13 patients with special focus on course and treatment. (9428835)
1997
41
Pulmonary capillary leak syndrome associated with the use of intravenous cyclosporin. (8941609)
1996
42
Biclonal SAczary syndrome with capillary leak syndrome. (8136545)
1994
43
Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation. (8110879)
1994
44
Idiopathic capillary leak syndrome complicated by massive rhabdomyolysis. (8325053)
1993
45
Control of systemic capillary leak syndrome with aminophylline and terbutaline. (1580299)
1992
46
Pulmonary capillary leak syndrome complicating generalized pustular psoriasis: possible role of cytokines. (1751356)
1991
47
Muscle biopsy findings in systemic capillary leak syndrome. (2179110)
1990
48
Systemic capillary leak syndrome. (2563486)
1989
49
Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome. (3625226)
1987
50
Capillary leak syndrome with pulmonary edema. (5035983)
1972

Variations for Capillary Leak Syndrome

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Expression for genes affiliated with Capillary Leak Syndrome

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Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for genes affiliated with Capillary Leak Syndrome

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Pathways related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CSF2, IL2
29.8ELANE, ALB
39.6CSF2, IL8
49.3IL6, ELANE
59.3C4A, C3, C1S
6
Show member pathways
9.3C1S, C3, C4A
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.2IL2, IL8, CSF2
89.0IL6, IL8
99.0IL6, IL8
10
Show member pathways
9.0IL2, IL6, CSF2
11
Show member pathways
9.0CSF2, IL6, IL2
12
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0IL2, IL6, CSF2
139.0IL2, IL6, CSF2
14
Show member pathways
9.0C1S, ELANE, C3, C4A
15
Show member pathways
8.9C4A, IL6, IL2
16
Show member pathways
8.9C3, IL6, IL2
178.8CSF3, CSF2, IL6
18
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.8C4A, C3, SERPING1, C1S
19
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
8.8C1S, SERPING1, C3, C4A
20
Show member pathways
8.7CSF2, IL6, IL8
218.7CSF2, IL6, IL8
228.7IL8, IL6, CSF2
238.7IL2, IL8, IL6
248.7IL2, IL8, IL6
258.7IL6, IL8, IL2
268.6C4A, IL6, IL8
278.6IL8, IL6, C3
288.5IL8, IL6, CSF3
29
Show member pathways
Type III interferon signaling38
8.5IL2, IL6, CSF2, CSF3
308.5IL2, IL6, CSF2, CSF3
318.4CSF2, IL6, IL8, ELANE
328.4IL2, IL8, IL6, CSF2
33
Show member pathways
8.2IL2, IL8, IL6, C3
34
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.2IL2, IL8, IL6, C3
35
Show member pathways
8.2CSF3, CSF2, IL6, IL8
36
Show member pathways
7.9IL2, IL8, IL6, CSF2, CSF3
37
Show member pathways
7.9CSF3, CSF2, IL6, IL8, IL2
38
Show member pathways
7.9IL2, IL8, IL6, CSF2, CSF3
39
Show member pathways
7.9IL2, IL8, IL6, CSF2, CSF3
407.4C4A, C3, IL6, IL8, SERPING1, C1S

Compounds for genes affiliated with Capillary Leak Syndrome

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Compounds related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1pegfilgrastim45 1310.7CSF2, ELANE, CSF3
2molgramostim459.7CSF3, IL2, CSF2
3dacarbazine45 1310.6CSF3, IL2, CSF2
4bcnu459.5CSF3, IL2, CSF2
5salmeterol45 51 30 1312.5IL2, CSF2, IL8
6zidovudine45 51 1311.3CSF2, CSF3, ALB, IL2
7pixy321459.2IL6, CSF2, CSF3
8okt3459.2CSF2, IL6, IL2
9fluticasone propionate45 51 61 1312.1ELANE, IL8, CSF2
10sivelestat459.1IL6, ELANE, IL8
11olopatadine45 1310.1IL6, CSF2, IL8
12tepoxalin459.1IL8, IL2, IL6
13n-formylmethionyl-leucylphenylalanine459.1IL8, CSF2, CSF3, ELANE
14gabexate mesilate459.1IL6, IL8, ELANE
15taurine chloramine459.1IL6, IL8, IL2
16ulinastatin459.1IL6, ELANE, IL8
17mip 1alpha459.1IL6, CSF2, IL8
18imiquimod45 61 30 1312.0CSF2, IL6, IL8
19filgrastim45 139.9CSF3, CSF2, IL6, ELANE
20fmlp458.9ELANE, IL8, CSF2, CSF3
21groalpha458.9CSF2, IL8, IL6
22il-12458.8IL8, IL6, CSF2, IL2
23aprotinin45 139.8IL6, IL8, ELANE, C1S
24triptolide458.8IL2, IL6, IL8
25il 10458.8IL6, IL8, IL2, CSF2
26protamine458.8IL2, IL6, ELANE, IL8
27etanercept45 51 1310.7C1S, IL8, IL6
28leukotriene b445 61 2610.7IL6, ELANE, CSF2, IL8
29prednisolone45 30 1310.7IL6, CSF3, ALB, IL2
30rituximab45 51 1310.6CSF3, CSF2, IL6, IL2, C1S
31calcitriol45 61 26 1311.6ALB, IL2, IL6, CSF2
32herbimycin a45 619.6IL2, IL6, IL8, CSF2
33fibrinogen458.6C1S, ELANE, ALB, IL6, C3
34pentoxifylline45 139.5CSF2, IL6, IL8, IL2, ELANE
35hydrocortisone45 3 61 1311.5IL2, IL6, ELANE, IL8, CSF2
36hyaluronic acid45 269.5CSF2, IL6, ALB, IL8, ELANE
37polyinosinic-polycytidylic acid458.4IL8, IL6, IL2
38histamine45 30 2610.3IL8, IL2, IL6, CSF2, ALB
39pge2458.3IL6, CSF2, IL8, IL2, ELANE
40rantes458.3IL6, CSF3, CSF2, IL8, IL2
41neopterin458.1ELANE, IL2, IL8, IL6, C3, CSF2
42heparin45 30 26 1311.0C1S, SERPING1, ELANE, IL8, ALB, C3
43anaphylatoxin458.0C4A, ELANE, IL6, IL8, C3, CSF2
44gm-csf45 309.0IL2, IL8, IL6, CSF2, CSF3, ELANE
45lactate458.0IL6, ALB, CSF2, ELANE, IL8, C3
46cyclosporin a45 30 6110.0CSF3, ELANE, IL2, IL8, IL6, CSF2
47cycloheximide457.9IL8, CSF3, IL2, IL6, CSF2
48endotoxin457.9C4A, CSF3, IL6, IL8, ELANE, CSF2
49serine457.8C3, IL8, IL2, C4A, ELANE, SERPING1
50dexamethasone45 51 30 1310.7CSF2, C3, CSF3, IL6, IL2, IL8

GO Terms for genes affiliated with Capillary Leak Syndrome

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Cellular components related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, SERPING1
2blood microparticleGO:00725628.1SERPING1, C3, ALB, C4A, C1S
3extracellular spaceGO:00056156.4SERPING1, IL2, IL8, IL6, C3, CSF2
4extracellular regionGO:00055766.0C4A, C1S, SERPING1, ELANE, IL2, IL8

Biological processes related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9CSF2, IL2
2complement activationGO:00069569.6C1S, C3, C4A
3negative regulation of chemokine biosynthetic processGO:00450799.6IL6, ELANE
4regulation of complement activationGO:00304499.5C3, C4A
5positive regulation of immunoglobulin secretionGO:00510249.5IL2, IL6
6positive regulation of smooth muscle cell proliferationGO:00486619.3IL6, ELANE
7negative regulation of neuron deathGO:019012159.3CSF3, IL6
8cellular response to lipopolysaccharideGO:00712229.3CSF3, CSF2, IL8
9complement activation, classical pathwayGO:00069589.1C4A, C3, SERPING1, C1S
10positive regulation of DNA replicationGO:00457409.1CSF2, IL6
11innate immune responseGO:00450878.9C1S, SERPING1, C3, C4A
12platelet activationGO:00301688.8ALB, IL6, SERPING1
13positive regulation of cell proliferationGO:00082848.6IL2, IL6, CSF2, CSF3
14immune responseGO:00069558.5IL2, IL8, C3, CSF2, CSF3
15inflammatory responseGO:00069548.4IL8, IL6, C3, C4A

Molecular functions related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.6C4A, C3
2growth factor activityGO:00080838.5CSF3, CSF2, IL6, IL2
3cytokine activityGO:00051258.4IL2, IL6, CSF2, CSF3
4protein bindingGO:00055156.5C1S, SERPING1, ELANE, IL8, IL6, C3

Products for genes affiliated with Capillary Leak Syndrome

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Sources for Capillary Leak Syndrome

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet