MCID: CPL003
MIFTS: 41

Capillary Leak Syndrome malady

Categories: Cardiovascular diseases, Rare diseases, Bone diseases

Aliases & Classifications for Capillary Leak Syndrome

Aliases & Descriptions for Capillary Leak Syndrome:

Name: Capillary Leak Syndrome 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14400
MeSH 42 D019559
NCIt 47 C62578
SNOMED-CT 64 87730004
UMLS 69 C0343084

Summaries for Capillary Leak Syndrome

MalaCards based summary : Capillary Leak Syndrome is related to hepatitis and nasopharyngitis. An important gene associated with Capillary Leak Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and bone marrow.

Wikipedia : 71 Capillary leak syndrome (also known as systemic capillary leak syndrome, SCLS, or Clarkson’s disease)... more...

Related Diseases for Capillary Leak Syndrome

Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.9 IL2 IL6
2 nasopharyngitis 29.5 CXCL8 IL2 IL6
3 systemic capillary leak syndrome 12.6
4 compartment syndrome 10.2
5 shoulder impingement syndrome 10.2 ALB IL6
6 bacterial conjunctivitis 10.2 ALB CXCL8
7 inner ear disease 10.2 ALB IL6
8 dermatomycosis 10.2 ALB C4A
9 glucosephosphate dehydrogenase deficiency 10.2 ALB IL6
10 oculomotor nerve paralysis 10.2 CXCL8 IL6
11 endotheliitis 10.2
12 common peroneal nerve lesion 10.2 CXCL8 IL6
13 krauss herman holmes syndrome 10.2 ALB EDNRA
14 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL6
15 psychotic disorder 10.2 CXCL8 IL6
16 kidney leiomyosarcoma 10.2 C4A IL6
17 schwannoma of ureter 10.2 CXCL8 IL6
18 retinal vascular disease 10.2 CXCL8 IL6
19 childhood electroclinical syndrome 10.2 CXCL8 IL6
20 cataract 10.2 ALB CSF2
21 lepromatous leprosy 10.2 C4A IL6
22 exudative vitreoretinopathy 2, x-linked 10.2 ALB CSF2
23 necrotizing gastritis 10.2 ALB CSF2
24 larynx carcinoma in situ 10.2 CXCL8 IL6
25 mikulicz disease 10.2 ALB IL6
26 bullous retinoschisis 10.2 CXCL8 IL6
27 carbuncle 10.2 CXCL8 IL6
28 vitreoretinopathy, neovascular inflammatory 10.2 CXCL8 IL6
29 immunodeficiency by defective expression of hla class 1 10.2 EDNRA IL6
30 larynx leiomyoma 10.2 CXCL8 IL6
31 neutrophilia, hereditary 10.2 CSF2 IL6
32 trichomalacia 10.2 CXCL8 IL6
33 chromophobe adenoma 10.1 CXCL8 IL2
34 cicatricial lagophthalmos 10.1 CXCL8 IL6
35 lateral cystocele 10.1 CXCL8 IL6
36 hereditary alpha tryptasemia syndrome 10.1 ALB IL6
37 cerebral sarcoidosis 10.1 ALB IL2
38 gastric dilatation 10.1 CXCL8 IL6
39 acquired thrombocytopenia 10.1 CXCL8 IL6
40 fallopian tube carcinoma 10.1 CXCL8 IL2
41 plantar wart 10.1 CXCL8 IL2
42 acute allergic sanguinous otitis media 10.1 IL2 IL6
43 amyotrophic lateral sclerosis type 14 10.1 CXCL8 IL2
44 lymphoma 10.1
45 hidradenitis 10.1 CSF2 CXCL8
46 laryngotracheoesophageal cleft type 2 10.1 IL2 IL6
47 sarcoma 10.1 CSF2 IL2
48 tinea capitis 10.1 IL2 IL6
49 clostridium difficile colitis 10.1 IL2 IL6
50 autosomal recessive type iv ehlers-danlos syndrome 10.1 CXCL8 IL6

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to Capillary Leak Syndrome

Symptoms & Phenotypes for Capillary Leak Syndrome

Drugs & Therapeutics for Capillary Leak Syndrome

Drugs for Capillary Leak Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
2
Dalteparin Approved Phase 3 9041-08-1
3
Isotretinoin Approved Phase 3,Phase 2 4759-48-2 5538 5282379
4
Aldesleukin Approved Phase 3,Phase 2 85898-30-2, 110942-02-4
5
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
6
Acetaminophen Approved Phase 3 103-90-2 1983
7
Ibuprofen Approved Phase 3 15687-27-1 3672
8
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Codeine Approved, Illicit Phase 3 76-57-3 5284371
11
Guaifenesin Approved, Vet_approved Phase 3 93-14-1 3516
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
13
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 5538
14 calcium heparin Phase 3
15 Heparin, Low-Molecular-Weight Phase 3
16 Vasoconstrictor Agents Phase 3
17 Pharmaceutical Solutions Phase 3,Phase 1
18 Interleukin-2 Phase 3,Phase 2
19 Analgesics Phase 3,Phase 2
20 Analgesics, Non-Narcotic Phase 3,Phase 2
21 Dermatologic Agents Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 3,Phase 2
23 Vitamins Phase 3
24 Immunoglobulins Phase 3,Phase 2
25 Anti-HIV Agents Phase 3,Phase 2
26 Anti-Infective Agents Phase 3,Phase 2
27 Antibodies, Monoclonal Phase 3
28 Keratolytic Agents Phase 3,Phase 2
29 Anti-Retroviral Agents Phase 3,Phase 2
30 Retinol palmitate Phase 3
31 Antibodies Phase 3,Phase 2
32 Antiviral Agents Phase 3,Phase 2
33 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
34
Serotonin Phase 3 50-67-9 5202
35 Serotonin Agents Phase 3
36 Serotonin Antagonists Phase 3
37 Narcotics Phase 3
38 Gastrointestinal Agents Phase 3
39 Neurotransmitter Agents Phase 3
40 Cyclooxygenase Inhibitors Phase 3
41 Analgesics, Opioid Phase 3
42 Tranquilizing Agents Phase 3
43 Dopamine Agents Phase 3
44 Dopamine Antagonists Phase 3
45 Dopamine D2 Receptor Antagonists Phase 3
46 Anti-Anxiety Agents Phase 3
47 Antiemetics Phase 3
48 Anti-Inflammatory Agents Phase 3
49 Psychotropic Drugs Phase 3
50 Anti-Inflammatory Agents, Non-Steroidal Phase 3

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function Unknown status NCT01077895 Phase 3
2 Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Completed NCT01041638 Phase 3
3 Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy Terminated NCT00147355 Phase 3
4 NB2013-HR German (GPOH) / Dutch (DCOG) Trial Terminated NCT02641782 Phase 2
5 DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma Completed NCT00889408 Phase 1
6 Human Leukocyte Antigen (HLA) Class I Haplotype Mismatched Natural Killer Cell Infusions Completed NCT00660166 Phase 1
7 Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia Completed NCT00167167
8 A Clinical Study of Fundus Findings in Toxaemia of Pregnancy Completed NCT03076619
9 An Observational Study of the Role of Intra-abdominal Pressure Monitoring in Patients With Acute Pancreatitis Completed NCT01611532
10 Studies in the Pathogenesis of Systemic Capillary Leak Syndrome Recruiting NCT00936325
11 Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery Recruiting NCT02853682
12 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
13 Measurement of Extravascular Lung Water to Detect and Predict Primary Graft Dysfunction Following Lung Transplant Recruiting NCT01605214
14 Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass Not yet recruiting NCT02965339

Search NIH Clinical Center for Capillary Leak Syndrome

Cochrane evidence based reviews: capillary leak syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

MalaCards organs/tissues related to Capillary Leak Syndrome:

39
Endothelial, Bone, Bone Marrow, Lung, T Cells, Breast, B Cells

Publications for Capillary Leak Syndrome

Articles related to Capillary Leak Syndrome:

(show top 50) (show all 225)
id Title Authors Year
1
A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting. ( 27069700 )
2016
2
Subcutaneous Immunoglobulin Therapy Prevents Systemic Capillary Leak Syndrome Attack. ( 27059380 )
2016
3
Idiopathic Systemic Capillary Leak Syndrome: A Case Report. ( 27195144 )
2016
4
Sudden cardiac arrest in a 73-year-old woman caused by systemic capillary leak syndrome. ( 27056382 )
2016
5
A Case of Refractory Systemic Capillary Leak Syndrome (Clarkson's Disease) during Pregnancy. ( 28003676 )
2016
6
Fatal Primary Capillary Leak Syndrome in a Late Preterm Newborn. ( 27142601 )
2016
7
Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single-center cohort study. ( 27734564 )
2016
8
Compartment Syndrome as a Result of Systemic Capillary Leak Syndrome. ( 27688917 )
2016
9
Microangiopathic Hemolytic Anemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. ( 27622772 )
2016
10
Scrub typhus presenting as capillary leak syndrome. ( 27728427 )
2016
11
Idiopathic systemic capillary leak syndrome (Clarkson disease). ( 28012935 )
2016
12
Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate. ( 27338086 )
2016
13
Rhabdomyolysis and capillary leak syndrome in a patient treated with topical imiquimod. ( 27061736 )
2016
14
Systemic capillary leak syndrome and autoimmune diseases: A case series. ( 27637319 )
2016
15
Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. ( 27386947 )
2016
16
Severe cerebral involvement due to idiopathic systemic capillary leak syndrome. ( 27099745 )
2016
17
97: PEDIATRIC SYSTEMIC CAPILLARY LEAK SYNDROME ENDOTHELIAL CELLS ARE HYPERSENSITIVE TO TNF-I9 AND LPS. ( 26569758 )
2015
18
Recurrent undifferentiated shock: Idiopathic Systemic Capillary Leak Syndrome. ( 26273434 )
2015
19
Metabolic Serum Profiles for Patients Receiving Allogeneic Stem Cell Transplantation: The Pretransplant Profile Differs for Patients with and without Posttransplant Capillary Leak Syndrome. ( 26609191 )
2015
20
Systemic capillary leak syndrome in a patient receiving adjuvant oxaliplatin for locally advanced colon cancer. ( 26071595 )
2015
21
Endothelial Expression of Endothelin Receptor A in the Systemic Capillary Leak Syndrome. ( 26176954 )
2015
22
Increased myocardial extracellular volume in active idiopathic systemic capillary leak syndrome. ( 26310790 )
2015
23
Multiglandular hormone deficiency in a patient with systemic capillary leak syndrome. ( 25685157 )
2015
24
1197: ACUTE THERAPY WITH IVIG IN A PEDIATRIC PATIENT WITH IDIOPATHIC SYSTEMIC CAPILLARY LEAK SYNDROME. ( 26570858 )
2015
25
1222: SUCCESSFUL MANAGEMENT OF RECURRENT IDIOPATHIC SYSTEMIC CAPILLARY LEAK SYNDROME IN A 4-YEAR OLD GIRL. ( 26570883 )
2015
26
Clinical and pathological findings of a fatal systemic capillary leak syndrome (Clarkson disease): a case report. ( 25738482 )
2015
27
Influenza A virus infection is associated with systemic capillary leak syndrome: case report and systematic review of the literature. ( 26330157 )
2015
28
Spinal Anesthesia in a Patient With a History of Systemic Capillary Leak Syndrome (Clarkson Disease). ( 26237002 )
2015
29
A fatal case of acute progression of generalized edema and simultaneous flash pulmonary edema in a patient with idiopathic systemic capillary leak syndrome: a case report. ( 25928289 )
2015
30
Interleukin-11-induced capillary leak syndrome companied with abdominal chylous leakage in primary sigmoid carcinoma patients with thrombocytopenia. ( 26881585 )
2015
31
Systemic Capillary Leak Syndrome after Influenza Vaccination in a Peritoneal Dialysis Patient. ( 26703855 )
2015
32
Clofarabine associated capillary leak syndrome in a child with lymphoma successfully treated with intravenous immunoglobulin. ( 26458636 )
2015
33
An uncommon cause of distributive shock: Lessons from two consecutive cases of idiopathic systemic capillary leak syndrome (Clarkson's disease). ( 26300309 )
2015
34
Idiopathic systemic capillary leak syndrome in children. ( 25713284 )
2015
35
A case report of idiopathic systemic capillary leak syndrome that occurred during the postoperative period of abdominoperineal resection for colorectal cancer. ( 25594640 )
2015
36
Correction: Endothelial Expression of Endothelin Receptor A in the Systemic Capillary Leak Syndrome. ( 26325591 )
2015
37
In vitro Study of the Antagonistic Effect of Low-dose Liquiritigenin on Gemcitabine-induced Capillary Leak Syndrome in Pancreatic Adenocarcinoma via Inhibiting ROS- Mediated Signalling Pathways. ( 26028101 )
2015
38
Systemic capillary leak syndrome: a case-report. ( 26117513 )
2015
39
Intravenous immunoglobulin in systemic capillary leak syndrome: a case report and review of literature. ( 24490827 )
2014
40
Fulminant systemic capillary leak syndrome due to C1 inhibitor deficiency complicating acute dermatomyositis: a case report. ( 24467750 )
2014
41
Systemic capillary leak syndrome revealing a diffuse large B-cell lymphoma. ( 24942976 )
2014
42
Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome. ( 24859554 )
2014
43
Systemic capillary leak syndrome under general anesthesia: a case report. ( 25006371 )
2014
44
Systemic capillary leak syndrome associated with a rare abdominal and four-limb compartment syndrome: a case report. ( 24934689 )
2014
45
High dose intravenous immunoglobulin therapy of the Systemic Capillary Leak Syndrome (Clarkson disease). ( 25193271 )
2014
46
"Grastims" and fatal capillary leak syndrome. ( 24678521 )
2014
47
10-year-old girl with life-threatening idiopathic systemic capillary leak syndrome: a case report. ( 24885961 )
2014
48
Two Episodes of Systemic Capillary Leak Syndrome in an 8-year-old Boy, Following Influenza A Virus Infection. ( 23995592 )
2014
49
Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease). ( 25405070 )
2014
50
Systemic capillary leak syndrome: is methylene blue the silver bullet? ( 25544902 )
2014

Variations for Capillary Leak Syndrome

Expression for Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for Capillary Leak Syndrome

Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 C4A CXCL8 IL2 IL6
2
Show member pathways
12.22 CSF2 IL2 IL6
3 12.21 CSF2 IL2 IL6
4
Show member pathways
12.12 ALB IL2 IL6
5
Show member pathways
12.11 CSF2 CXCL8 IL6
6 12.03 CSF2 CXCL8 IL6
7
Show member pathways
12.01 CSF2 IL2 IL6
8 11.97 C4A CXCL8 IL6
9
Show member pathways
11.94 CXCL8 IL2 IL6
10 11.8 CXCL8 IL2 IL6
11 11.78 CSF2 IL2 IL6
12 11.68 CSF2 CXCL8 IL6
13
Show member pathways
11.65 CSF2 CXCL8 IL6
14 11.63 CSF2 CXCL8 IL6
15 11.59 CSF2 CXCL8 IL6
16
Show member pathways
11.51 CSF2 CXCL8 IL2
17 11.49 CSF2 IL2 IL6
18 11.38 CSF2 CXCL8 IL6
19 11.37 CSF2 CXCL8 IL2 IL6
20 11.34 CXCL8 IL6
21 11.32 CSF2 IL6
22
Show member pathways
11.24 CSF2 IL2
23 11.23 CSF2 CXCL8 IL6
24 11.15 CXCL8 IL6
25 11.14 CSF2 CXCL8
26 11.14 C1S C4A CXCL8 IL6
27 10.91 CSF2 IL2 IL6
28 10.85 CXCL8 IL6
29 10.85 CSF2 CXCL8 IL2 IL6
30
Show member pathways
10.72 CSF2 CXCL8 IL2 IL6

GO Terms for Capillary Leak Syndrome

Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB C4A IL6
2 extracellular space GO:0005615 9.43 ALB C4A CSF2 CXCL8 IL2 IL6
3 blood microparticle GO:0072562 9.33 ALB C1S C4A
4 extracellular region GO:0005576 9.17 ALB C1S C4A CSF2 CXCL8 IL2

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 CSF2 CXCL8 IL2 IL6
2 cellular protein metabolic process GO:0044267 9.54 ALB C4A IL6
3 positive regulation of DNA replication GO:0045740 9.4 CSF2 IL6
4 cellular response to lipopolysaccharide GO:0071222 9.33 CSF2 CXCL8 IL6
5 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.32 CSF2 IL2
6 positive regulation of immunoglobulin secretion GO:0051024 8.96 IL2 IL6
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.8 CSF2 IL2 IL6

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CSF2 IL2 IL6
2 cytokine activity GO:0005125 8.92 CSF2 CXCL8 IL2 IL6

Sources for Capillary Leak Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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