MCID: CPL003
MIFTS: 44

Capillary Leak Syndrome malady

Summaries for Capillary Leak Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Capillary leak syndrome (usually Systemic Capillary Leak Syndrome, SCLS or Clarkson’s Disease) is an... more...

MalaCards: Capillary Leak Syndrome is related to hepatitis c and kawasaki disease. An important gene associated with Capillary Leak Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are Rho Family GTPases and Rheumatoid arthritis. The compounds gabexate mesilate and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and skeletal muscle, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Capillary Leak Syndrome

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

capillary leak syndrome 8 10 45 61


External Ids:

Disease Ontology8 DOID:14400
MeSH35 D019559
SNOMED-CT57 87730004
NCIt40 C62578

Related Diseases for Capillary Leak Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases in the systemic capillary leak syndrome family:

capillary leak syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c30.2ALB
2kawasaki disease30.2ELANE
3acute leukemia30.2IL2, CSF3, CSF2
4adult respiratory distress syndrome30.2ELANE, IL8
5thrombocytopenia30.2CSF2, CSF3, IL6, IL2, ALB
6vascular disease30.2IL8, IL6, IL2, C3, ELANE
7sepsis30.1CSF2, C1S, CSF3, C4A, IL8, ELANE
8systemic capillary leak syndrome11.2
9n syndrome10.7
10adult syndrome10.3
11mass syndrome10.3
12generalized pustular psoriasis10.3
13status epilepticus10.2
14polycythemia vera10.2
15hemophagocytic lymphohistiocytosis10.2
16pulmonary edema10.2
17pancytopenia10.2
18cardia cancer10.2
19anterior compartment syndrome10.2
20anaplastic large cell lymphoma10.2
21small intestine lymphoma10.2
22micro syndrome10.2
23engraftment syndrome10.2
24kid syndrome10.2
25lip disease10.2
26null syndrome10.2
27ischemia10.0C1S
28dermatitis10.0CSF2
29sarcoidosis10.0IL2
30aspergillosis10.0ELANE
31toxic shock syndrome10.0IL2
32gingivitis10.0ELANE
33leprosy10.0IL2
34malignant glioma10.0IL2
35neuropathy10.0ALB
36crohn's disease10.0ALB
37malaria10.0ALB
38hypereosinophilic syndrome10.0CSF2
39pulmonary alveolar proteinosis10.0CSF2
40cholangitis10.0ALB
41hypertension10.0ALB
42ovarian hyperstimulation syndrome10.0ALB
43lymphatic system disease10.0ALB
44nephrotic syndrome10.0ALB
45ulcerative colitis10.0ALB
46hypercalcemia10.0ALB
47hyperhomocysteinemia10.0ALB
48myasthenia gravis10.0IL2
49liver cirrhosis10.0ALB
50alpha 1-antitrypsin deficiency10.0ELANE

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to capillary leak syndrome

Clinical Features for Capillary Leak Syndrome

Drugs & Therapeutics for Capillary Leak Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Capillary Leak Syndrome

Drug clinical trials:

Search ClinicalTrials for Capillary Leak Syndrome

Search NIH Clinical Center for Capillary Leak Syndrome

Search CenterWatch for Capillary Leak Syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Capillary Leak Syndrome:

33
Bone marrow, Heart, Skeletal muscle, Small intestine, Kidney, Liver, Lung, Breast, T cells, Endothelial

Animal Models for Capillary Leak Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Capillary Leak Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1C3
2MP:00020068.8IL6, IL2, ALB, ELANE
3MP:00053977.5ELANE, C3, IL2, IL6, IL8, CSF3
4MP:00053877.2CSF2, CSF3, IL8, IL6, IL2, C3

Publications for Capillary Leak Syndrome

Sources:
51PubMed
See all sources

Articles related to Capillary Leak Syndrome:

(show top 50)    (show all 177)
idTitleAuthorsYear
1
Episodic idiopathic systemic capillary leak syndrome in a girl. (23910812)
2013
2
Separate episodes of capillary leak syndrome and pulmonary hypertension after adjuvant gemcitabine and three years later after nab-paclitaxel for metastatic disease. (24215543)
2013
3
Early prediction of capillary leak syndrome in infants after cardiopulmonary bypass. (23389476)
2013
4
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma. (22953081)
2012
5
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). (22411873)
2012
6
Capillary leak syndrome and abdominal compartment syndrome from occult rectal malignancy. (23089411)
2012
7
Capillary leak syndrome in trauma: what is it and what are the consequences? (22873043)
2012
8
The systemic capillary leak syndrome: a case series of 28 patients from a European registry. (21464348)
2011
9
Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome. (20603623)
2011
10
Idiopathic systemic capillary leak syndrome preceding diagnosis of infiltrating lobular carcinoma of the breast with quiescence during neoadjuvant chemotherapy. (21364118)
2011
11
High-dose intravenous immunoglobulins: a promising therapeutic approach for idiopathic systemic capillary leak syndrome. (22696704)
2011
12
Systemic capillary leak syndrome. (21738986)
2011
13
Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab. (20360479)
2010
14
Idiopathic systemic capillary leak syndrome (Clarkson's disease): the Mayo clinic experience. (20634497)
2010
15
Recurrent capillary leak syndrome following bortezomib therapy in a patient with relapsed myeloma. (20150504)
2010
16
Systemic capillary leak syndrome should be considered in the differential diagnosis of multi-organ failure and hypovolemic shock. (20508484)
2010
17
Systemic sclerosis, capillary leak syndrome and nasopharyngeal carcinoma: an unusual association or paraneoplastic manifestations? (19052056)
2009
18
Vascular endothelial growth factor in systemic capillary leak syndrome. (19486705)
2009
19
Beneficial effect of intravenous immunoglobulins on systemic capillary leak syndrome in patients with monoclonal gammopathy. (19325398)
2009
20
Abdominal compartment syndrome associated with capillary leak syndrome after liver transplantation. (19917414)
2009
21
High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome. (18552679)
2008
22
Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? (17897725)
2007
23
Acitretin induces capillary leak syndrome in a patient with pustular psoriasis. (17097361)
2007
24
Systemic capillary leak syndrome presenting as recurrent shock. (16738498)
2006
25
Severe gemcitabine-induced capillary-leak syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease. (15630853)
2004
26
Validation of C1-esterase inhibitor therapy in severe capillary leak syndrome by monitoring of extravascular lung water. (14727019)
2004
27
Capillary leak syndrome induced by acitretin. (14746632)
2004
28
Systemic capillary leak syndrome. (11929183)
2002
29
Plasma vascular endothelial growth factor level is a predictor of the severity of postoperative capillary leak syndrome in neonates undergoing cardiopulmonary bypass. (11793065)
2002
30
Hypoalbuminemia, surgical leak, and clinical capillary leak syndrome. (10636355)
2000
31
Capillary leak syndrome in a patient treated with interleukin 2 fusion toxin for cutaneous T-cell lymphoma. (10906662)
2000
32
Treatment of the systemic capillary leak syndrome with terbutaline and theophylline. A case series. (10375339)
1999
33
Soluble L-selectin plasma concentrations in infants undergoing heart surgery: no association with capillary leak syndrome or need for respiratory support. (9840246)
1998
34
Chronic systemic capillary leak syndrome not requiring treatment? (9809704)
1998
35
Systemic capillary leak syndrome: report on 13 patients with special focus on course and treatment. (9428835)
1997
36
C1 esterase inhibitor concentrate for capillary leakage syndrome following bone marrow transplantation. (9368478)
1997
37
A case of rapidly fatal systemic capillary leak syndrome in a kidney transplant recipient. (9489137)
1997
38
Systemic capillary leak syndrome in a child. (7472826)
1995
39
A fatal case of capillary leak syndrome in erythrodermic psoriasis. (7756137)
1995
40
Adult respiratory distress syndrome complicating a systemic capillary leak syndrome. (8046129)
1994
41
Systemic capillary leak syndrome. (8222853)
1993
42
The paraproteins in systemic capillary leak syndrome. (8370170)
1993
43
Control of systemic capillary leak syndrome with aminophylline and terbutaline. (1580299)
1992
44
Muscle biopsy findings in systemic capillary leak syndrome. (2179110)
1990
45
Histamine release in paediatric cardiopulmonary bypass--a possible role in the capillary leak syndrome. (2440282)
1987
46
Remission of SAczary's syndrome with cyclosporin A. Mild capillary leak syndrome as an unusual side effect. (2424226)
1986
47
Postpartum capillary leak syndrome. A case report. (7428393)
1980
48
Systemic capillary leak syndrome. Evaluation of single protein fractions in serum and in interstitial fluid. (496875)
1979
49
Systemic capillary leak syndrome with monoclonal IgG and complement alterations. A case report on an episodic syndrome. (525442)
1979
50
Systemic capillary leak syndrome and monoclonal IgG gammopathy; studies in a sixth patient and a review of the literature. (870792)
1977

Genetic Variations for Capillary Leak Syndrome

Expression for genes affiliated with Capillary Leak Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for genes affiliated with Capillary Leak Syndrome

Sources:
52QIAGEN, 30KEGG, 53R&D Systems, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 56SinoBiological
See all sources

Pathways related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CSF2
210.2CSF2
310.1C3
4
Hide members
9.9IL2, CSF2
59.7C4A, C3
6
Hide members
9.7CSF2, CSF3
7
Hide members
9.7CSF2, CSF3
89.5IL2, IL6
99.4C3, C1S, C4A
10
Hide members
9.4CSF2, IL8, IL2
11
Hide members
9.2IL6, IL2, CSF2
129.0IL8, CSF2, IL6
139.0CSF2, IL8, IL6
149.0CSF2, CSF3, IL6
159.0IL2, IL8, IL6
169.0IL2, IL8, IL6
17
Hide members
9.0C3, SERPING1, C4A, C1S
18
Immune response Lectin induced complement pathway
Hide members
9.0SERPING1, C1S, C4A, C3
19
Hide members
9.0C4A, SERPING1, C3, C1S
209.0C4A, IL8, IL6
218.9IL6, C3, IL8
228.7CSF2, IL8, IL6, ELANE
238.7CSF2, IL8, IL2, IL6
248.7IL2, CSF2, CSF3, IL6
25
Hide members
8.6C3, IL6, IL8, IL2
26
Hide members
8.6IL2, C3, IL6, IL8
27
Cytokine production by Th17 cells in CF (Mouse model)
8.5IL8, CSF2, CSF3, IL6
28
Hide members
8.2IL6, CSF2, CSF3, IL8, IL2
297.8C4A, IL8, IL6, SERPING1, C3, C1S
30
Hide members
7.8IL6, C4A, CSF2, POLR3G, IL2, C1S

Compounds for genes affiliated with Capillary Leak Syndrome

Sources:
45Novoseek, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1gabexate mesilate4510.6ELANE
2ulinastatin4510.6ELANE
3sivelestat sodium hydrate4510.4ELANE
4pentoxifylline45 1111.3CSF2, ELANE
5pge24510.1CSF2, IL2
6hydrocortisone45 2 60 1113.1IL8, ELANE
7cyclosporin a45 29 6012.1ELANE, CSF3
8endotoxin4510.0CSF3, C4A
9pegfilgrastim45 1110.8ELANE, CSF3, CSF2
10romurtide459.8CSF2, CSF3
11molgramostim459.8CSF2, CSF3, IL2
12dexamethasone45 50 29 1112.8IL6, C3
13aprotinin45 1110.8IL8, ELANE, C1S
14salmeterol45 50 29 1112.7CSF2, IL8, IL2
15dacarbazine45 1110.7CSF3, IL2, CSF2
16bcnu459.7IL2, CSF3, CSF2
17fmlp459.6ELANE, CSF3, CSF2
18fluticasone propionate45 50 60 1112.6ELANE, IL8, CSF2
19okt3459.5IL6, IL2, CSF2
20emedastine45 1110.5IL8, IL6
21sivelestat459.5IL8, IL6, ELANE
22anaphylatoxin459.4IL8, ELANE, C4A, CSF2
23pixy321459.4IL6, CSF3, CSF2
24tepoxalin459.4IL6, IL2, IL8
25olopatadine45 1110.4IL6, IL8, CSF2
26mip 1alpha459.4IL8, CSF2, IL6
27taurine chloramine459.4IL2, IL8, IL6
28zidovudine45 1110.4ALB, IL2, CSF3, CSF2
29imiquimod45 29 60 1112.4IL6, IL8, CSF2
30groalpha459.3CSF2, IL8, IL6
31mycophenolate mofetil45 50 1111.3IL2, CSF3, ALB
32n-formylmethionyl-leucylphenylalanine459.3CSF3, ELANE, IL8, CSF2
33triptolide459.3IL6, IL8, IL2
34filgrastim45 1110.2CSF2, ELANE, IL6, CSF3
35il-12459.2IL2, CSF2, IL6, IL8
36il 10459.1IL2, IL6, IL8, CSF2
37rantes459.1CSF2, IL2, IL6, CSF3
38leukotriene b445 60 2411.1ELANE, IL6, IL8, CSF2
39polyinosinic-polycytidylic acid459.1IL6, IL8, IL2
40etanercept45 50 1111.1IL6, IL8, C1S
41herbimycin a45 6010.0IL2, IL6, IL8, CSF2
42rituximab45 50 1110.9C1S, CSF2, IL2, IL6, CSF3
43fibrinogen458.9ALB, IL6, C1S, C3, ELANE
44hyaluronic acid45 249.8ALB, IL6, IL8, CSF2, ELANE
45calcitriol45 60 11 2411.8ALB, IL6, CSF2, IL2
46serine458.8SERPING1, IL8, C3
47histamine45 29 2410.7IL6, ALB, CSF2, IL8, IL2
48heparin45 29 11 2411.7IL8, ELANE, C1S, CSF2, C3, SERPING1
49neopterin458.5IL6, CSF2, IL2, C3, ELANE, IL8
50lactate458.4ELANE, IL6, IL8, CSF2, C3, ALB

GO Terms for genes affiliated with Capillary Leak Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.6C1S, CSF2, C4A, IL8, IL6, IL2
2extracellular spaceGO:0056156.3CSF2, CSF3, C4A, IL8, IL6, IL2

Biological processes related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:0450799.8IL6, ELANE
2regulation of complement activationGO:0304499.7C3, C4A
3complement activationGO:0069569.6C3, C4A, C1S
4positive regulation of immunoglobulin secretionGO:0510249.6IL2, IL6
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6IL2, CSF2
6negative regulation of neuron deathGO:19012159.4IL6, CSF3
7cellular response to lipopolysaccharideGO:0712229.3CSF2, CSF3, IL8
8complement activation, classical pathwayGO:0069589.2C3, SERPING1, C4A, C1S
9immune responseGO:0069558.7CSF2, CSF3, IL8, IL2, C3
10positive regulation of cell proliferationGO:0082848.6CSF2, CSF3, IL6, IL2
11inflammatory responseGO:0069548.6C4A, IL8, IL6, C3
12innate immune responseGO:0450878.3C1S, C4A, POLR3G, SERPING1, C3

Molecular functions related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7IL2, IL6, CSF3, CSF2
2growth factor activityGO:0080838.4IL2, IL6, CSF3, CSF2

Products for genes affiliated with Capillary Leak Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Capillary Leak Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet