MCID: CPL003
MIFTS: 47

Capillary Leak Syndrome malady

Summaries for Capillary Leak Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Capillary leak syndrome (usually Systemic Capillary Leak Syndrome, SCLS or Clarkson’s Disease) is an... more...

MalaCards: Capillary Leak Syndrome is related to psoriasis and myeloma. An important gene associated with Capillary Leak Syndrome is C1S (complement component 1, s subcomponent), and among its related pathways are Rho Family GTPases and Rheumatoid arthritis. The compounds gabexate mesilate and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone marrow and bone, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Capillary Leak Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

capillary leak syndrome 8 10 44 60


External Ids:

Disease Ontology8 DOID:14400
MeSH34 D019559
SNOMED-CT56 87730004
NCIt39 C62578

Related Diseases for Capillary Leak Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Systemic Capillary Leak Syndrome family:

capillary leak syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.7IL8, IL2, ELANE, IL6
2myeloma30.5IL6, IL2, CSF3, ALB, CSF2
3leukemia30.4IL6, CSF3, CSF2, IL2
4hepatitis c30.2ALB
5hypertension30.2ALB
6kawasaki disease30.2ELANE
7diarrhea30.2ALB, IL2
8pancreatic cancer30.2IL8
9acute leukemia30.1CSF2, CSF3, IL2
10adult respiratory distress syndrome30.1IL8, ELANE
11multiple myeloma30.1CSF3, IL6
12pancreatitis30.1ELANE, C1S, IL6, ALB
13thrombocytopenia30.1CSF2, ALB, IL6, CSF3, IL2
14vascular disease30.1ELANE, C3, IL2, IL6, IL8
15systemic capillary leak syndrome10.8
16compartment syndrome10.6
17capillary disease10.6
18hepatitis10.4
19influenza10.4
20adult syndrome10.3
21brucellosis10.3
22cutaneous t cell lymphoma10.3
23syndromic diarrhea10.1
24status epilepticus10.1
25polycythemia vera10.1
26hemophagocytic lymphohistiocytosis10.1
27pulmonary edema10.1
28cerebritis10.1
29pancytopenia10.1
30nasopharyngitis10.1
31anterior compartment syndrome10.1
32anaplastic large cell lymphoma10.1
33small intestine lymphoma10.1
34breast cancer10.1
35histiocytosis10.1
36lymphoblastic leukemia10.1
37polycythemia10.1
38renal cell carcinoma10.1
39ischemia10.0C1S
40dermatitis10.0CSF2
41aspergillosis10.0ELANE
42sarcoidosis10.0IL2
43toxic shock syndrome10.0IL2
44gingivitis10.0ELANE
45leprosy10.0IL2
46malignant glioma10.0IL2
47neuropathy10.0ALB
48crohn's disease10.0ALB
49malaria10.0ALB
50hypereosinophilic syndrome10.0CSF2

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to capillary leak syndrome

Clinical Features for Capillary Leak Syndrome

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Drugs & Therapeutics for Capillary Leak Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Capillary Leak Syndrome

Drug clinical trials:

Search ClinicalTrials for Capillary Leak Syndrome

Search NIH Clinical Center for Capillary Leak Syndrome

Search CenterWatch for Capillary Leak Syndrome

Genetic Tests for Capillary Leak Syndrome

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Anatomical Context for Capillary Leak Syndrome

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32MalaCards
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MalaCards organs/tissues related to Capillary Leak Syndrome:

32
Endothelial, Bone marrow, Bone, Lung, T cells, Breast, Heart, Skeletal muscle, Small intestine, Liver, Kidney

Animal Models for Capillary Leak Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Capillary Leak Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1C3
2MP:00020068.8ELANE, ALB, IL2, IL6
3MP:00053977.5IL2, IL8, C3, ELANE, CSF3, CSF2
4MP:00053877.2ELANE, CSF2, CSF3, IL8, IL6, IL2

Publications for Capillary Leak Syndrome

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50PubMed
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Articles related to Capillary Leak Syndrome:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
An unusual cause of secondary capillary leak syndrome in a child: rotavirus diarrhea. (23692840)
2013
2
Distributive shock due to systemic capillary leak syndrome treated with high-dose immunosuppression. (23576661)
2013
3
Malignant hemispheric cerebral infarction associated with idiopathic systemic capillary leak syndrome. (24163674)
2013
4
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma. (22953081)
2012
5
The systemic capillary leak syndrome: a scarcely known nephrological entity. (22135035)
2012
6
Myocardial involvement in systemic capillary leak syndrome: first demonstration by pathologic findings. (24062914)
2012
7
Idiopathic systemic capillary leak syndrome (Clarkson's disease): the Mayo clinic experience. (20634497)
2010
8
A case report of systemic capillary leak syndrome (Clarkson's disease). (20148770)
2010
9
The systemic capillary leak syndrome. (21135304)
2010
10
Immunoglobulins for treatment of systemic capillary leak syndrome. (20569743)
2010
11
Status epilepticus and capillary leak syndrome in a neonate related to perinatal hypoxic-ischemic encephalopathy. (20140779)
2010
12
Pulmonary capillary leak syndrome after influenza A (H1N1) virus infection. (20825864)
2010
13
Narrative review: the systemic capillary leak syndrome. (20643990)
2010
14
Chronic systemic capillary leak syndrome: a case responding to prednisolone treatment. (20166237)
2009
15
Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks. (19703708)
2009
16
Acute pulmonary capillary leak syndrome during elective surgery under general anesthesia. (18306021)
2008
17
The first documented case of brucellosis manifested with pancytopenia and capillary leak syndrome. (18451581)
2008
18
Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years. (17575386)
2007
19
Gemcitabine-induced chronic systemic capillary leak syndrome: a life-threatening disease. (16477934)
2006
20
Idiopathic systemic capillary leak syndrome misdiagnosed and treated as polycythemia vera. (15802896)
2005
21
Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass: a double-blind, randomised controlled study. (16099291)
2005
22
Idiopathic systemic capillary leak syndrome: cutaneous involvement can be misleading. (15539891)
2004
23
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF). (12692521)
2003
24
Systemic capillary leak syndrome. (12487166)
2002
25
Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome. (11591575)
2001
26
Systemic capillary leak syndrome preceding plasma cell leukaemia. (11713377)
2001
27
Capillary leak syndrome in a patient treated with interleukin 2 fusion toxin for cutaneous T-cell lymphoma. (11174402)
2001
28
Systemic capillary leak syndrome associated with rhabdomyolysis and compartment syndrome. (10597109)
1999
29
Capillary leak syndrome in a patient with septicemia and granulocyte-colony-stimulating factor (G-CSF)-induced accelerated granulopoiesis. (9680943)
1998
30
Systemic capillary leak syndrome. (9870846)
1998
31
Role of nitric oxide in IL-2 therapy-induced capillary leak syndrome. (9544428)
1998
32
Idiopathic capillary leak syndrome: evidence of CD8-positive lymphocytes surrounding damaged endothelial cells. (9058699)
1997
33
Fulminating systemic capillary leak syndrome with lymphocytosis and hypogammaglobulinemia. (8570875)
1995
34
Systemic capillary leak syndrome. (7829741)
1995
35
Postpartum systemic capillary leak syndrome: a possible etiology. (7778436)
1995
36
Biclonal SAczary syndrome with capillary leak syndrome. (8136545)
1994
37
Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation. (8110879)
1994
38
Capillary leak syndrome likely the result of granulocyte colony-stimulating factor after high-dose chemotherapy. (7517230)
1994
39
Capillary leak syndrome in patients with hemophagocytic lymphohistiocytosis. (7841719)
1994
40
Control of systemic capillary leak syndrome with aminophylline and terbutaline. (1580299)
1992
41
GM-CSF therapy and capillary-leak syndrome. (2031971)
1991
42
High urinary leukotriene E4 (LTE4) and thromboxane 2 (TXB2) levels are associated with capillary leak syndrome in bone marrow transplant patients. (1847564)
1991
43
Activation of the complement system during immunotherapy of cancer with interleukin-2: a possible explanation of the capillary leak syndrome. (2093734)
1990
44
Capillary leak syndrome during low dose granulocyte-macrophage colony-stimulating factor (rh GM-CSF) treatment of a patient in a continuous febrile state. (2224143)
1990
45
Systemic capillary leak syndrome. (2201996)
1990
46
Systemic capillary leak syndrome. (2563486)
1989
47
Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome. (3625226)
1987
48
Production of 5-lipoxygenase pathway metabolites by peripheral leucocytes in capillary leak syndrome (Clarkson disease). (3032644)
1987
49
Ultrastructure of the microvessels in skeletal muscle in a case of systemic capillary leak syndrome. (525443)
1979
50
Capillary leak syndrome with pulmonary edema. (5035983)
1972

Genetic Variations for Capillary Leak Syndrome

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Expression for genes affiliated with Capillary Leak Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for genes affiliated with Capillary Leak Syndrome

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51QIAGEN, 29KEGG, 52R&D Systems, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 55SinoBiological
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Pathways related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CSF2
210.2CSF2
310.1C3
4
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9.9IL2, CSF2
59.7C4A, C3
6
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9.7CSF2, CSF3
7
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9.7CSF3, CSF2
89.5IL2, IL6
99.4C3, C4A, C1S
10
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9.4CSF2, IL8, IL2
11
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9.2CSF2, IL6, IL2
129.0IL6, IL8, CSF2
139.0IL6, IL8, CSF2
149.0CSF2, CSF3, IL6
159.0IL8, IL6, IL2
169.0IL2, IL6, IL8
17
Immune response Lectin induced complement pathway
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9.0C3, SERPING1, C4A, C1S
18
Hide members
9.0C1S, C4A, SERPING1, C3
19
Hide members
9.0C1S, C4A, SERPING1, C3
209.0C4A, IL8, IL6
218.9C3, IL6, IL8
228.7ELANE, IL6, IL8, CSF2
238.7CSF2, IL8, IL6, IL2
248.7CSF2, CSF3, IL6, IL2
25
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8.6IL8, IL6, IL2, C3
26
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8.6C3, IL2, IL6, IL8
27
Cytokine production by Th17 cells in CF (Mouse model)
8.5CSF2, CSF3, IL8, IL6
28
Hide members
8.2CSF2, CSF3, IL8, IL6, IL2
297.8C3, SERPING1, IL6, IL8, C4A, C1S
30
Hide members
7.8C1S, CSF2, C4A, POLR3G, IL6, IL2

Compounds for genes affiliated with Capillary Leak Syndrome

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44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1gabexate mesilate4410.6ELANE
2ulinastatin4410.6ELANE
3sivelestat sodium hydrate4410.4ELANE
4pentoxifylline44 1111.3CSF2, ELANE
5pge24410.1CSF2, IL2
6hydrocortisone44 2 59 1113.1IL8, ELANE
7cyclosporin a44 28 5912.1ELANE, CSF3
8endotoxin4410.0CSF3, C4A
9pegfilgrastim44 1110.8ELANE, CSF3, CSF2
10romurtide449.8CSF2, CSF3
11molgramostim449.8CSF2, CSF3, IL2
12dexamethasone44 49 28 1112.8IL6, C3
13aprotinin44 1110.8IL8, ELANE, C1S
14salmeterol44 49 28 1112.7CSF2, IL8, IL2
15dacarbazine44 1110.7CSF3, IL2, CSF2
16bcnu449.7IL2, CSF3, CSF2
17fmlp449.6ELANE, CSF3, CSF2
18fluticasone propionate44 49 59 1112.6ELANE, IL8, CSF2
19okt3449.5IL6, IL2, CSF2
20emedastine44 1110.5IL8, IL6
21sivelestat449.5IL8, IL6, ELANE
22anaphylatoxin449.4IL8, ELANE, C4A, CSF2
23pixy321449.4IL6, CSF3, CSF2
24tepoxalin449.4IL6, IL2, IL8
25olopatadine44 1110.4IL6, IL8, CSF2
26mip 1alpha449.4IL8, CSF2, IL6
27taurine chloramine449.4IL2, IL8, IL6
28zidovudine44 1110.4ALB, IL2, CSF3, CSF2
29imiquimod44 28 59 1112.4IL6, IL8, CSF2
30groalpha449.3CSF2, IL8, IL6
31mycophenolate mofetil44 49 1111.3IL2, CSF3, ALB
32n-formylmethionyl-leucylphenylalanine449.3CSF3, ELANE, IL8, CSF2
33triptolide449.3IL6, IL8, IL2
34filgrastim44 1110.2CSF2, ELANE, IL6, CSF3
35il-12449.2IL2, CSF2, IL6, IL8
36il 10449.1IL2, IL6, IL8, CSF2
37rantes449.1CSF2, IL2, IL6, CSF3
38leukotriene b444 59 2411.1ELANE, IL6, IL8, CSF2
39polyinosinic-polycytidylic acid449.1IL6, IL8, IL2
40etanercept44 49 1111.1IL6, IL8, C1S
41herbimycin a44 5910.0IL2, IL6, IL8, CSF2
42rituximab44 49 1110.9C1S, CSF2, IL2, IL6, CSF3
43fibrinogen448.9ALB, IL6, C1S, C3, ELANE
44hyaluronic acid44 249.8ALB, IL6, IL8, CSF2, ELANE
45calcitriol44 59 11 2411.8ALB, IL6, CSF2, IL2
46serine448.8SERPING1, IL8, C3
47histamine44 28 2410.7IL6, ALB, CSF2, IL8, IL2
48heparin44 28 11 2411.7IL8, ELANE, C1S, CSF2, C3, SERPING1
49neopterin448.5IL6, CSF2, IL2, C3, ELANE, IL8
50lactate448.4ELANE, IL6, IL8, CSF2, C3, ALB

GO Terms for genes affiliated with Capillary Leak Syndrome

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16Gene Ontology
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Cellular components related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.6CSF2, C4A, IL8, IL6, IL2, SERPING1
2extracellular spaceGO:0056156.3ALB, CSF2, CSF3, C4A, IL8, IL6

Biological processes related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of chemokine biosynthetic processGO:0450799.8IL6, ELANE
2regulation of complement activationGO:0304499.7C3, C4A
3complement activationGO:0069569.6C3, C4A, C1S
4positive regulation of immunoglobulin secretionGO:0510249.6IL2, IL6
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6IL2, CSF2
6negative regulation of neuron deathGO:19012159.4IL6, CSF3
7cellular response to lipopolysaccharideGO:0712229.3CSF2, CSF3, IL8
8complement activation, classical pathwayGO:0069589.2C3, SERPING1, C4A, C1S
9immune responseGO:0069558.7CSF2, CSF3, IL8, IL2, C3
10positive regulation of cell proliferationGO:0082848.6CSF2, CSF3, IL6, IL2
11inflammatory responseGO:0069548.6C4A, IL8, IL6, C3
12innate immune responseGO:0450878.3C1S, C4A, POLR3G, SERPING1, C3

Molecular functions related to Capillary Leak Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7IL2, IL6, CSF3, CSF2
2growth factor activityGO:0080838.4IL2, IL6, CSF3, CSF2

Products for genes affiliated with Capillary Leak Syndrome

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  • Antibodies
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Sources for Capillary Leak Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet