MCID: CRB025
MIFTS: 37

Carbohydrate Metabolic Disorder malady

Summaries for Carbohydrate Metabolic Disorder

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates.

MalaCards: Carbohydrate Metabolic Disorder, also known as disorder of carbohydrate transport and metabolism, is related to pentosuria and pulmonary tuberculosis. An important gene associated with Carbohydrate Metabolic Disorder is INS (insulin), and among its related pathways are PPAR signaling pathway and Nuclear Receptor transcription pathway. The compounds actos and gi262570 have been mentioned in the context of this disorder. Related mouse phenotypes are integument and renal/urinary system.

Aliases & Classifications for Carbohydrate Metabolic Disorder

Sources:
8Disease Ontology, 61UMLS, 35MeSH
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Aliases & Descriptions:

carbohydrate metabolic disorder 8
disorder of carbohydrate transport and metabolism 8
inborn errors of carbohydrate metabolism 8
inborn carbohydrate metabolism disorder 8


External Ids:

Disease Ontology8 DOID:2978
MeSH35 D002239

Related Diseases for Carbohydrate Metabolic Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Carbohydrate Metabolic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1pentosuria10.4
2pulmonary tuberculosis10.1
3fructose-1,6-bisphosphatase deficiency10.1
4hyperinsulinemic hypoglycemia10.1
5n syndrome10.1
6thyroiditis10.1
7tuberculosis10.1
8morbid obesity10.0INS
9pancreatitis10.0INS
10maturity-onset diabetes of the young10.0INS
11blindness10.0INS
12vascular disease10.0HP
13arteriosclerosis10.0PPARG
14familial hyperlipidemia10.0INS
15hepatitis10.0HP
16endometriosis10.0HP
17diabetic retinopathy10.0INS
18hepatitis b10.0PPARA
19adenocarcinoma10.0PPARA
20pituitary tumors10.0PPARG
21osteoarthritis10.0PPARA
22psoriasis10.0PPARA
23batten disease10.0HP
24hyperandrogenism10.0INS, PPARG
25pneumonia10.0PPARA
26galactosemia10.0HP, INS
27essential hypertension10.0HP, INS
28prediabetes syndrome10.0INS, PPARG
29thyroid cancer10.0PPARG
30familial partial lipodystrophy10.0INS, PPARG
31congenital generalized lipodystrophy type 210.0INS, PPARG
32hypercholesterolemia10.0PPARA, INS
33cystic fibrosis10.0INS, HP
34metabolic syndrome x10.0PPARG, INS
35ischemia10.0HP, PPARA
36schizophrenia10.0PPARA, INS
37leiomyoma10.0IRS1
38familial combined hyperlipidemia10.0PPARA, INS
39rheumatoid arthritis10.0HP
40hepatitis c10.0HP, IRS1
41liver cirrhosis10.0HP, IRS1
42medulloblastoma10.0IRS1
43diabetes mellitus, noninsulin-dependent10.0IRS1, IRS2
44tangier disease10.0PPARA, PPARG
45rectum cancer10.0IRS2, IRS1
46idiopathic edema10.0INS, PPARA, PPARG
47hypertension10.0PPARA, PPARG, INS
48alzheimer's disease10.0PPARG, INS, PPARA
49adenoma10.0PPARG, INS, PPARA
50glioblastoma multiforme10.0PPARA, PPARG

Graphical network of the top 20 diseases related to Carbohydrate Metabolic Disorder:



Diseases related to carbohydrate metabolic disorder

Clinical Features for Carbohydrate Metabolic Disorder

Drugs & Therapeutics for Carbohydrate Metabolic Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Carbohydrate Metabolic Disorder

Drug clinical trials:

Search ClinicalTrials for Carbohydrate Metabolic Disorder

Search NIH Clinical Center for Carbohydrate Metabolic Disorder

Search CenterWatch for Carbohydrate Metabolic Disorder

Genetic Tests for Carbohydrate Metabolic Disorder

Anatomical Context for Carbohydrate Metabolic Disorder

Animal Models for Carbohydrate Metabolic Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Carbohydrate Metabolic Disorder

Sources:
51PubMed
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Articles related to Carbohydrate Metabolic Disorder:

idTitleAuthorsYear
1
Protective effects of vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats. (23819528)
2013
2
Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy. (23633838)
2013
3
Screening using serum percentage of carbohydrate-deficient transferrin for congenital disorders of glycosylation in children with suspected metabolic disease. (18024528)
2008
4
Characteristics of lipid profile in blood plasma of patients with metabolic syndrome and manifest disorder of carbohydrate metabolism]. (14669600)
2003
5
Carbohydrate metabolic disorder in women with a neuroendocrine syndrome]. (8017575)
1994
6
Glycosylated proteins and the rheological properties of the erythrocytes in carbohydrate metabolic disorders]. (1803588)
1991
7
Autotransplantation of pancreatic tail tissue to prevent carbohydrate metabolic disorder following total pancreatectomy. A case report with preliminary experience. (6816515)
1982

Genetic Variations for Carbohydrate Metabolic Disorder

Expression for genes affiliated with Carbohydrate Metabolic Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carbohydrate Metabolic Disorder

Search GEO for disease gene expression data for Carbohydrate Metabolic Disorder.

Pathways for genes affiliated with Carbohydrate Metabolic Disorder

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 52QIAGEN, 50PharmGKB, 4Cell Signaling Technology
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Pathways related to Carbohydrate Metabolic Disorder according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PPARG, PPARA
2
Hide members
9.3PPARA, PPARG
39.3PPARA, PPARG
49.3PPARA, PPARG
59.2INS, IRS1
69.2IRS1, INS
79.2IRS1, INS
89.2INS, IRS1
9
Development EPO-induced Jak-STAT pathway
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9.2IRS1, IRS2
10
Development Leptin signaling via PI3K-dependent pathway
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9.2IRS1, IRS2
11
Hide members
9.2IRS2, IRS1
129.2IRS2, IRS1
139.2IRS1, IRS2
149.2IRS1, IRS2
159.2IRS1, IRS2
16
Hide members
9.2IRS1, IRS2
179.2IRS1, IRS2
18
Hide members
8.8IRS2, IRS1, INS
19
Development Prolactin receptor signaling
Hide members
8.8INS, IRS1, IRS2
20
Hide members
8.8INS, IRS1, IRS2
218.8INS, IRS1, IRS2
22
Translation Insulin regulation of translation
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8.8IRS2, IRS1, INS
23
Hide members
8.8INS, IRS1, IRS2
24
Hide members
8.8INS, IRS1, IRS2
25
Hide members
8.8IRS2, IRS1, INS
26
Hide members
8.8IRS2, IRS1, INS
278.6IRS2, IRS1, PPARA
28
Development Ligand-independent activation of ESR1 and ESR2
Hide members
8.5IRS1, PPARA, PPARG
298.3INS, PPARG, IRS1, IRS2
307.6INS, PPARG, PPARA, IRS1, IRS2
31
Hide members
7.6IRS2, IRS1, PPARA, PPARG, INS

Compounds for genes affiliated with Carbohydrate Metabolic Disorder

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Carbohydrate Metabolic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1actos459.9INS, PPARG
2gi262570459.7PPARA, PPARG
3gw 1929459.7PPARA, PPARG
4ragaglitazar45 2910.7PPARG, PPARA
5ly-510929299.7PPARA, PPARG
6mono(2-ethylhexyl)phthalate459.7PPARG, PPARA
7ly-465608299.7PPARG, PPARA
8hbig459.7INS, PPARG
9mk-0767299.7PPARA, PPARG
10reglitazar299.7PPARG, PPARA
11tzd18299.7PPARA, PPARG
12farglitazar299.7PPARA, PPARG
13ad-5061299.7PPARA, PPARG
14gw409544299.7PPARA, PPARG
15tetradecylthioacetic acid459.6PPARG, PPARA
16gw 764745 6010.6PPARG, PPARA
17bisphenol a diglycidyl ether459.6PPARA, PPARG
18ALEGLITAZAR 119.6PPARG, PPARA
19gw9578299.6PPARA, PPARG
20mitiglinide45 1110.5INS, PPARG
213-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid119.4PPARA, PPARG
22gw50151645 2910.4PPARG, PPARA
23acarbose45 1110.4PPARG, PPARA, INS
24telmisartan45 29 1111.3INS, PPARG, PPARA
25gemfibrozil45 29 1111.3INS, PPARG, PPARA
26bezafibrate45 29 1111.3PPARG, INS, PPARA
27tesaglitazar459.2PPARG, PPARA
28fenofibrate45 50 1111.2INS, PPARG, PPARA
29glucose459.1IRS2, PPARG, IRS1
30dexamethasone45 50 29 1112.1IRS1, INS, PPARA
31ritonavir45 50 1111.0IRS1, PPARG, INS
32prostaglandin j2459.0PPARA, PPARG
33carnitine458.9PPARG, INS, PPARA
342-deoxyglucose45 119.9IRS1, PPARG, INS
35niacin45 119.8HP, PPARG, PPARA, INS
36thiazolidinedione458.5PPARA, INS, PPARG, IRS1
37pioglitazone45 50 29 1111.5IRS1, PPARA, INS, PPARG
38palmitate458.5PPARG, IRS1, PPARA, INS
39ibmx45 29 6010.5PPARA, IRS1, PPARG, INS
40rapamycin458.5IRS2, IRS1, INS, PPARG
41fatty acid458.5IRS2, IRS1, PPARG, PPARA
42ly294002458.5IRS1, PPARG, IRS2, INS
43sterol458.5IRS1, PPARG, IRS2, PPARA
44aspirin45 50 29 2411.4HP, PPARG, PPARA, IRS1
45metformin45 50 1110.1PPARA, PPARG, INS, IRS2, IRS1
46rosiglitazone45 50 29 11 2412.1IRS1, PPARA, PPARG, INS, IRS2
47troglitazone45 29 60 1111.1PPARG, INS, PPARA, IRS1, IRS2
48testosterone45 60 11 2411.0HP, INS, PPARG, IRS1, PPARA
49alanine457.6INS, IRS2, IRS1, PPARA, HP, PPARG
50lipid457.5IRS2, IRS1, PPARA, PPARG, INS, HP

GO Terms for genes affiliated with Carbohydrate Metabolic Disorder

Sources:
16Gene Ontology
See all sources

Biological processes related to Carbohydrate Metabolic Disorder according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:0026749.8PPARG, INS
2lipid homeostasisGO:0550889.7PPARG, IRS2
3negative regulation of receptor biosynthetic processGO:0108719.7PPARA, PPARG
4positive regulation of fatty acid oxidationGO:0463219.6PPARA, PPARG
5negative regulation of sequestering of triglycerideGO:0108919.6PPARA, PPARG
6negative regulation of cholesterol storageGO:0108879.6PPARG, PPARA
7acute-phase responseGO:0069539.5INS, HP
8negative regulation of macrophage derived foam cell differentiationGO:0107459.5PPARG, PPARA
9positive regulation of insulin receptor signaling pathwayGO:0466289.5IRS1, INS
10positive regulation of glucose metabolic processGO:0109079.5IRS1, IRS2
11wound healingGO:0420609.4INS, PPARA
12mammary gland developmentGO:0308799.3IRS2, IRS1
13JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.3IRS1, IRS2
14positive regulation of mesenchymal cell proliferationGO:0020539.3IRS1, IRS2
15positive regulation of glycogen biosynthetic processGO:0457259.1INS, IRS1, IRS2
16positive regulation of glucose importGO:0463269.1IRS2, IRS1, INS
17glucose homeostasisGO:0425939.0INS, PPARG, IRS1
18positive regulation of cell migrationGO:0303359.0INS, IRS1, IRS2
19cellular response to insulin stimulusGO:0328699.0PPARG, IRS1, IRS2
20insulin receptor signaling pathwayGO:0082869.0IRS2, IRS1, INS
21response to insulin stimulusGO:0328688.9IRS1, PPARA
22positive regulation of fatty acid beta-oxidationGO:0320008.9PPARA, IRS1, IRS2
23positive regulation of cell proliferationGO:0082848.5INS, IRS1, IRS2

Molecular functions related to Carbohydrate Metabolic Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.4INS, IRS1
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.3PPARG, PPARA
3drug bindingGO:0081449.3PPARG, PPARA
4phosphatidylinositol 3-kinase bindingGO:0435489.3IRS2, IRS1
5steroid hormone receptor activityGO:0037079.2PPARG, PPARA
6insulin receptor bindingGO:0051588.9INS, IRS1, IRS2
7protein bindingGO:0055156.8HP, PPARG, PPARA, IRS1, IRS2, INS

Products for genes affiliated with Carbohydrate Metabolic Disorder

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  • Proteins
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Sources for Carbohydrate Metabolic Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet