MCID: CRC006
MIFTS: 55

Carcinoid Syndrome malady

Endocrine, Cancer categories

Summaries for Carcinoid Syndrome

Sources:
43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A carcinoid tumor is a rare, slow-growing cancer that usually starts in the lining of the digestive tract (appendix, stomach, small intestine, colon, rectum) or in the lungs but may occur elsewhere. because carcinoid tumors grow slowly and don't produce symptoms in the early stages, affected individuals may have the tumor for years before being diagnosed. in later stages the tumor sometimes produces hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for a carcinoid tumor. if it does not spread to other parts of the body, surgery can typically cure the cancer. last updated: 4/9/2012

MalaCards: Carcinoid Syndrome, also known as carcinoid tumor, is related to teratoma and serotonin syndrome. An important gene associated with Carcinoid Syndrome is SST (somatostatin), and among its related pathways are G alpha (q) signalling events and Class A/1 (Rhodopsin-like receptors). The drug interferon alfa-2b and the compounds estrogen and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are renal/urinary system and nervous system.

MedlinePlus:34 Carcinoid tumors are rare, slow-growing cancers. they usually start in the lining of the digestive tract or in the lungs. they grow slowly and don't produce symptoms in the early stages. as a result, the average age of people diagnosed with digestive or lung carcinoids is about 60. in later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for carcinoid tumors. if they haven't spread to other parts of the body, surgery can cure the cancer.

Wikipedia:64 Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. The... more...

Aliases & Classifications for Carcinoid Syndrome

Sources:
43NIH Rare Diseases, 61UMLS, 45Novoseek, 34MedlinePlus, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

carcinoid syndrome 43
carcinoid tumor 43 61
malignant carcinoid syndrome 61
carcinoid tumor syndrome 43
carcinoid tumors 34
carcinoid 45


External Ids:

ICD1025 E34.0

Related Diseases for Carcinoid Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Carcinoid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.9ENO2
2serotonin syndrome30.8TAC1, SST, CHGA, GHRH, MEN1, GAST
3adenoma30.6CALCA, GAST, MEN1, GHRH, SYP, CHGA
4pernicious anemia30.6GAST
5atrophic gastritis30.6GAST, MEN1, CHGA, SST
6zollinger-ellison syndrome30.2SST, CHGA, GHRH, MEN1, GAST
7granular cell tumor30.2ENO2, SYP
8hypercalcemia30.2CALCA, GAST, MEN1, CHGA
9thyroid medullary carcinoma30.1CALCA, GAST, MEN1, CHGA, NTS, SST
10apudoma30.1CALCA, SST
11gastric outlet obstruction30.1GAST, MLN
12acromegaly30.1SST, GHRH, MEN1
13multiple endocrine neoplasia30.1CALCA, GAST, MEN1, CHGA
14hypoglycemia30.1NPY, PPY, GAST, MLN, GHRH, CHGA
15pheochromocytoma30.0PYY, CALCA, NPY, MEN1, MLN, SYP
16pancreatic endocrine carcinoma30.0SST, GAST
17large cell carcinoma30.0SYP, CHGA, ENO2
18phaeochromocytoma30.0CALCA, NPY, CHGA
19morbid obesity29.9PYY
20thymic carcinoma29.9SYP
21cholelithiasis29.9SST, UGT1A1
22deficiency anemia29.9GHRH, IFNA2
23tubular adenocarcinoma29.9SYP, CHGA, ENO2
24neurofibromatosis29.9MEN1, SST, ENO2
25prolactinoma29.9MEN1, CHGA, SST
26pancreatitis, chronic29.9UGT1A1, NTS, SST
27papillary carcinoma29.9CALCA, SYP, CHGA
28primary hyperparathyroidism29.9CHGA, MEN1, GAST, CALCA
29gastrinoma29.9GAST, MEN1, SYP, CHGA, SST, ENO2
30paraganglioma29.9CALCA, GAST, MEN1, SYP, CHGA, SST
31bipolar disorder29.9HTR3A
32hyperinsulinism29.8NPY, SST
33glucose intolerance29.8MLN, GAST, PYY
34somatostatinoma29.8CALCA, GAST, SST, CHGA, GHRH
35vipoma29.8CHGA, GHRH, MEN1, GAST, NTS, SST
36cushing's syndrome29.8CALCA, NPY, MEN1, GHRH, SYP, CHGA
37neuroendocrine carcinoma29.8SST, CHGA, SYP, MEN1, GAST, CALCA
38adenocarcinoma29.8PYY, GAST, UGT1A1, MEN1, SYP, CHGA
39duodenitis29.7GAST
40ileus29.7MLN
41von hippel-lindau disease29.7MEN1, NPY
42prader-willi syndrome29.7PYY, NPY
43pituitary tumors29.7MEN1, GHRH, CHGA, SST
44merkel cell carcinoma29.7SYP, CHGA, SST, ENO2
45wermer syndrome29.7GAST, MEN1, GHRH, CHGA, SST
46colorectal cancer29.7IFNA2, GAST, UGT1A1, NTS
47insulinoma29.6CALCA, GAST, MEN1, GHRH, CHGA, NTS
48n syndrome10.6
49goblet cell carcinoid10.6
50somatostatin analog10.5

Graphical network of the top 20 diseases related to Carcinoid Syndrome:



Diseases related to carcinoid syndrome

Clinical Features for Carcinoid Syndrome

Drugs & Therapeutics for Carcinoid Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Carcinoid Syndrome

Drug clinical trials:

Search ClinicalTrials for Carcinoid Syndrome

Search NIH Clinical Center for Carcinoid Syndrome

Search CenterWatch for Carcinoid Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Carcinoid Syndrome

Anatomical Context for Carcinoid Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Carcinoid Syndrome:

33
Skin, Ovary, Liver, Lung, Thymus, Heart, Small intestine, Colon, Pancreas, Prostate, Testis, Cervix, T cells, Appendix, Pancreatic islet, Pituitary

Animal Models for Carcinoid Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Carcinoid Syndrome

Sources:
51PubMed
See all sources

Articles related to Carcinoid Syndrome:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Ectopic Cushing's syndrome secondary to pulmonary carcinoid tumor. (23608267)
2013
2
Long-term results of treatment of malignant carcinoid syndrome with prolonged release Lanreotide (Somatuline Autogel). (21585408)
2011
3
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. (22119496)
2011
4
Atypical thymic carcinoid associated with Cushing's syndrome. (21319031)
2010
5
Primary liver carcinoid tumour with a Zollinger Ellison syndrome - an unusual diagnosis: a case report. (19918579)
2009
6
Valvular heart disease caused by carcinoid syndrome: emphasis on the use of intraoperative transesophageal echocardiography. (18068066)
2007
7
Multiple endocrine neoplasia type I and Cushing's syndrome due to an aggressive ACTH producing thymic carcinoid. (16484744)
2006
8
Imaging findings of a primary bilateral testicular carcinoid tumor associated with carcinoid syndrome. (16495507)
2006
9
Pathognomonic echocardiographic features of carcinoid syndrome. (16596839)
2006
10
A case of Lambert-Eaton myasthenic syndrome associated with atypical bronchopulmonary carcinoid tumor. (15483357)
2004
11
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. (14671177)
2003
12
Carcinoid tumor and carcinoid syndrome. (17021482)
2003
13
Neuropsychological investigation into the carcinoid syndrome. (12695876)
2003
14
Diagnosis of non-Zollinger-Ellison syndrome, non-carcinoid syndrome, enteropancreatic neuroendocrine tumours. (10604121)
1999
15
Troponin I, troponin T, and creatine kinase-MB mass in patients with the carcinoid syndrome with and without heart failure. (10585378)
1999
16
Ectopic Cushing's syndrome and pulmonary carcinoid tumour identified by [111In-DTPA-D-Phe1]octreotide. (9616493)
1998
17
Anesthesia for patients with carcinoid syndrome. (9444534)
1997
18
Cryosurgical debulking of unresectable liver metastases for palliation of carcinoid syndrome. (9122880)
1997
19
Octreotide inhibition of flushing and colonic motor dysfunction in carcinoid syndrome. (9399764)
1997
20
Treatment of the carcinoid syndrome with a depot formulation of the somatostatin analogue lanreotide. (7833124)
1994
21
Side effects and complications after hepatic artery embolization in the carcinoid syndrome. (1871548)
1991
22
Clinical features of carcinoid syndrome and the use of somatostatin analogue in its management. (2663049)
1989
23
Clinical and echocardiographic comparison of patients with the carcinoid syndrome with and without carcinoid heart disease. (2464278)
1989
24
Zollinger-Ellison syndrome, duodenal carcinoid (gastrinoma), and hyperthyroidism. (2508315)
1989
25
Therapy of the malignant carcinoid syndrome. (2663485)
1989
26
Successful treatment with a long-acting somatostatin analogue (SMS201-995) in a patient with malignant carcinoid syndrome. (3193661)
1988
27
Inhibitory effects of ranitidine on flushing and serum serotonin concentrations in carcinoid syndrome. (3128368)
1988
28
Distinguishing features of idiopathic flushing and carcinoid syndrome. (2461688)
1988
29
Verapamil and diarrhoea in the carcinoid syndrome--clinical and experimental observations on serotonin release. (3741762)
1986
30
Treatment of the malignant carcinoid syndrome. Evaluation of a long-acting somatostatin analogue. (2427948)
1986
31
Eleven-year follow-up after tricuspid valve replacement and pulmonic valvulotomy in the carcinoid syndrome. (6695803)
1984
32
Serotonin depletion by fenfluramine in the carcinoid syndrome. (7057838)
1982
33
Tamoxifen in carcinoid syndrome. (7231519)
1981
34
Anesthesia and the malignant carcinoid syndrome. (6166145)
1981
35
Anaesthesia and the carcinoid syndrome. (517724)
1979
36
Carcinoid syndrome treated by hepatic embolization. (99001)
1978
37
Hepatic dearterialization for carcinoid syndrome due to liver metastases. (900958)
1977
38
Ultrastructural cytochemistry of platelets and megakaryocytes in the carcinoid syndrome. (183065)
1976
39
Studies of tryptophan and albumin metabolism in a patient with carcinoid syndrome, pellagra, and hypoproteinemia. (133045)
1976
40
Alterations of pituitary-gonadal function in the carcinoid syndrome. (4451197)
1974
41
Chest pain in the carcinoid syndrome. (4193351)
1970
42
Metastatic carcinoid syndrome treated with methysergide. (5763541)
1969
43
Carcinoid tumors and the carcinoid syndrome. (5801424)
1969
44
Carcinoid syndrome and carcinoid tumours of the rectum. (5763892)
1969
45
Adenocarcinoma of the bronchus with Cushing's syndrome, carcinoid syndrome, neuromyopathy and urticaria. (5654985)
1968
46
MANAGEMENT OF CARCINOID SYNDROME. (14280243)
1965
47
CARCINOID SYNDROME RESULTING FROM A PRIMARY ARGENTAFFINOMA OF THE OVARY. (14263725)
1965
48
Hyperkinemia and cardiac failure in the carcinoid syndrome. (13909647)
1962
49
Carcinoid syndrome associated with adrenal hyperplasia. (13883958)
1962
50
Metabolic studies in carcinoid syndrome: observations on use of alpha-methyl DOPA, isonicotinic acid hydrazide and selective tryptophan deficiency. (13883956)
1961

Genetic Variations for Carcinoid Syndrome

Expression for genes affiliated with Carcinoid Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carcinoid Syndrome

Search GEO for disease gene expression data for Carcinoid Syndrome.

Pathways for genes affiliated with Carcinoid Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Carcinoid Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5TAC1
2111in-pentetreotide4510.1CALCA, SST, CHGA, SYP
3streptozotocin4510.0IFNA2, SYP, CHGA, SST
4guanine45 11 2411.9UGT1A1, CALCA, NTS
5lafutidine459.8SST, MLN, GAST, CALCA
6mibg459.8SST, ENO2, CHGA, CALCA
7bethanechol45 29 1111.8NPY, SST, MLN, GAST
8omeprazole45 29 50 11 2413.7CHGA, SST, MLN, PYY, GAST
9sumatriptan45 29 60 50 11 2414.7HTR7, HTR3A, MLN, GHRH, CALCA
10i-app459.6GAST, PYY, TAC1, CALCA
115-hydroxyindoleacetic acid45 2410.6ENO2, HTR3A, CHGA, SST, GAST
12gnrh459.6HTR7, CHGA, PYY, GAST, GHRH, NTS
13amphetamine45 1110.5TAC1, SST, NTS, NPY, PYY
14forskolin45 50 1111.5CALCA, TAC1, NPY, ENO2, GHRH
15c-peptide459.4PYY, SST, NTS, GAST, CHGA
16yohimbine45 29 2 1112.4GAST, NPY, HTR3A, HTR7, NTS, PYY
17dexamethasone45 50 29 1112.4HTR3A, UGT1A1, GHRH, NTS, TAC1, ENO2
18oxyntomodulin45 6010.3SST, NTS, PYY, NPY, GAST, MLN
19glutamate459.3HTR7, TAC1, NTS, GHRH, GAST, NPY
20clonidine45 29 1111.2PYY, CALCA, GHRH, CHGA, NTS, SST
21carbachol45 29 1111.2NPY, GAST, CHGA, NTS, SST, PYY
22glucose459.1NPY, GHRH, GAST, MLN, NTS, IFNA2
23haloperidol45 29 2 50 1113.1HTR3A, PYY, TAC1, NTS, CHGA, SYP
24propranolol45 29 50 11 2413.1TAC1, GAST, SST, PYY, CALCA, HTR3A
25isoproterenol45 1110.0TAC1, NTS, SST, CHGA, NPY, CALCA
26indomethacin45 60 29 1112.0NPY, CALCA, UGT1A1, NTS, TAC1, ENO2
27nifedipine45 50 29 1112.0GHRH, NPY, GAST, MLN, TAC1, SST
28epinephrine45 11 2410.9CALCA, IFNA2, NPY, GAST, SST, TAC1
29ondansetron45 50 11 2411.9HTR3A, MLN, GAST, TAC1
30amine458.9ENO2, SYP, UGT1A1, GAST, HTR3A, HTR7
31atropine45 29 1110.9TAC1, PYY, CALCA, NPY, GAST, MLN
32nicotine45 50 29 1111.9NTS, GAST, UGT1A1, NPY, CHGA, TAC1
33thyroxine45 249.9GAST, IFNA2, MLN, CALCA, NTS, GHRH
34cyclic amp45 249.8SYP, TAC1, NPY, CHGA, CALCA, PYY
35tetrodotoxin45 60 2910.8TAC1, PYY, CALCA, MLN, NTS, NPY
36cisplatin45 50 60 1111.7ENO2, IFNA2, HTR3A, GAST, UGT1A1, SYP
37arginine458.7NPY, UGT1A1, MLN, SST, NTS, CHGA
38norepinephrine45 11 2410.6NTS, CHGA, SYP, GHRH, GAST, NPY
39gaba458.5CHGA, ENO2, TAC1, SST, NTS, SYP
40nitric oxide45 11 2410.4TAC1, CHGA, GHRH, NPY, CALCA, MLN
41octreotide45 60 29 1111.4PYY, CALCA, IFNA2, NPY, MLN, GAST
42testosterone45 60 11 2411.4CALCA, UGT1A1, GAST, GHRH, SYP, CHGA
43acth458.2PYY, CALCA, ENO2, IFNA2, NPY, GAST
44dopamine45 29 11 2411.2HTR7, CHGA, GHRH, MLN, GAST, NPY
45histamine45 29 2410.1SYP, MLN, GAST, NPY, HTR3A, IFNA2
46adenylate458.0HTR7, MLN, GHRH, CHGA, NPY, SST
47tyrosine457.9TAC1, NTS, CHGA, GAST, SYP, ENO2
485-hydroxytryptamine457.8HTR7, HTR3A, NPY, GAST, MLN, CALCA
49acetylcholine45 50 29 11 2411.8TAC1, ENO2, SST, NTS, CHGA, SYP
50calcium45 50 11 2410.7SYP, ENO2, TAC1, NTS, CHGA, NPY

GO Terms for genes affiliated with Carcinoid Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5TAC1, SST, HTR3A, CALCA
2extracellular spaceGO:0056158.6PYY, CALCA, IFNA2, NPY, GHRH, SST
3extracellular regionGO:0055767.6TAC1, PYY, CALCA, IFNA2, NPY, PPY

Biological processes related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.0HTR3A, HTR7
2feeding behaviorGO:0076319.9CALCA, NPY, PYY
3regulation of blood pressureGO:0082179.6CALCA, TAC1, CHGA, NPY
4neuropeptide signaling pathwayGO:0072189.5TAC1, NPY, CALCA
5G-protein coupled receptor signaling pathwayGO:0071869.5SST, MLN, GAST, PYY
6digestionGO:0075869.4SST, UGT1A1, PPY, NPY, HTR3A, PYY
7synaptic transmissionGO:0072689.3TAC1, SST, NPY, HTR3A, HTR7
8inflammatory responseGO:0069549.1IFNA2, CALCA, TUSC2, TAC1
9cell-cell signalingGO:0072678.8SST, GHRH, MLN, TAC1, CALCA, TUSC2

Molecular functions related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6NPY, NTS, PYY
2receptor bindingGO:0051029.4CALCA, NPY, PPY, MLN
3hormone activityGO:0051798.9GAST, PYY, SST, MLN, CALCA, PPY

Products for genes affiliated with Carcinoid Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carcinoid Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet