MCID: CRC006
MIFTS: 61

Carcinoid Syndrome malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Carcinoid Syndrome

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44NIH Rare Diseases, 35MedlinePlus, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 A carcinoid tumor is a rare, slow-growing cancer that usually starts in the lining of the digestive tract (appendix, stomach, small intestine, colon, rectum) or in the lungs but may occur elsewhere. because carcinoid tumors grow slowly and don't produce symptoms in the early stages, affected individuals may have the tumor for years before being diagnosed. in later stages the tumor sometimes produces hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for a carcinoid tumor. if it does not spread to other parts of the body, surgery can typically cure the cancer. last updated: 4/9/2012

MalaCards: Carcinoid Syndrome, also known as carcinoid tumor, is related to pernicious anemia and atrophic gastritis. An important gene associated with Carcinoid Syndrome is SST (somatostatin), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and SIDS Susceptibility Pathways. The drug interferon alfa-2b and the compounds 111in-pentetreotide and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and colon, and related mouse phenotypes are adipose tissue and tumorigenesis.

MedlinePlus:35 Carcinoid tumors are rare, slow-growing cancers. they usually start in the lining of the digestive tract or in the lungs. they grow slowly and don't produce symptoms in the early stages. as a result, the average age of people diagnosed with digestive or lung carcinoids is about 60. in later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for carcinoid tumors. if they haven't spread to other parts of the body, surgery can cure the cancer.

Wikipedia:66 Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. The... more...

Aliases & Classifications for Carcinoid Syndrome

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44NIH Rare Diseases, 63UMLS, 46Novoseek, 35MedlinePlus, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

carcinoid syndrome 44
carcinoid tumor 44 63
malignant carcinoid syndrome 63
carcinoid tumor syndrome 44
carcinoid tumors 35
carcinoid 46


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ICD1026 E34.0

Related Diseases for Carcinoid Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Carcinoid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 357)
idRelated DiseaseScoreTop Affiliating Genes
1pernicious anemia30.8GAST
2atrophic gastritis30.7CHGA, SST, MEN1, GAST
3neuroendocrine carcinoma30.6CHGA, SST, MEN1, SYP, ENO2, GAST
4diarrhea30.5UGT1A1, CHGA, HTR3A, PYY, CALCA, SST
5granular cell tumor30.4ENO2, SYP
6constipation30.3PYY, HTR3A
7zollinger-ellison syndrome30.3GAST, GHRH, MEN1, SST, CHGA
8apudoma30.3CALCA, SST
9adenoma30.3GHRH, SYP, SST, CHGA, IGF1, PYY
10von hippel-lindau disease30.3NPY, VEGFA, MEN1
11hypercalcemia30.3MEN1, CALCA, GAST, CHGA
12neuroendocrine tumor30.2CALCA, GHRH, CHGA, SST
13lung cancer30.2GHRH, ENO2, SYP, VEGFA, CHGA
14acromegaly30.2IGF1, SST
15multiple endocrine neoplasia30.2MEN1, CHGA, CALCA, GAST
16phaeochromocytoma30.1CHGA, NPY, CALCA
17islet cell tumor30.1GAST, SST
18cholelithiasis30.1UGT1A1, SST
19sertoli cell tumor30.1SYP, ENO2
20neurofibromatosis30.1MEN1, ENO2, SST
21tubular adenocarcinoma30.1SYP, CHGA, ENO2
22cushing's syndrome30.1SST, GHRH
23ganglioneuroblastoma30.1ENO2, NPY, SYP
24primary hyperparathyroidism30.1GAST, CALCA, MEN1, CHGA
25hyperparathyroidism30.0CALCA, CHGA, GAST, MEN1
26papillary thyroid carcinoma30.0TKT, MEN1, CALCA
27hypopituitarism30.0SST, IGF1, GHRH
28hypoglycemia30.0IGF1, NPY, GAST, SST, CHGA, GHRH
29hypertension30.0IGF1, NPY, KNG1, CALCA
30prolactinoma30.0SST, IGF1, CHGA, MEN1
31bipolar disorder30.0NPY, HTR3A
32gastritis30.0CHGA, SST, GAST, NTS
33gastrinoma30.0GAST, SYP, MEN1, SST, CHGA, ENO2
34somatostatinoma29.9GAST, CALCA, GHRH, SST, CHGA
35vipoma29.9SST, GAST, GHRH, MEN1, NTS, CHGA
36paraganglioma29.9ENO2, GAST, CALCA, SYP, MEN1, SST
37hyperinsulinism29.9SST, IGF1, NPY
38angiodysplasia29.9SST
39dementia29.9SYP, KNG1, HTR3A
40pheochromocytoma29.9SYP, NTS, MEN1, SST, CHGA, PYY
41pituitary adenoma29.8SYP, NTS, SST, CHGA, IGF1, MEN1
42serotonin syndrome29.8MEN1, PYY, CHGA, HTR3A, IFNA2, SST
43obesity29.8NTS, PYY, IGF1, GHRH, KNG1, NPY
44merkel cell carcinoma29.8SYP, ENO2, CHGA
45wermer syndrome29.8SST, MEN1, GAST, CHGA
46hyperglycemia29.8TKT, NPY, GHRH, SST, IGF1, PYY
47neuroblastoma29.7KNG1, ENO2, SYP, NTS
48hyperthyroidism29.7IGF1, GHRH, NTS, SST
49prader-willi syndrome29.7IGF1, NPY, PYY
50pituitary tumors29.7MEN1, GHRH, IGF1, CHGA, SST

Graphical network of the top 20 diseases related to Carcinoid Syndrome:



Diseases related to carcinoid syndrome

Symptoms for Carcinoid Syndrome

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Drugs & Therapeutics for Carcinoid Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Carcinoid Syndrome

Drug clinical trials:

Search ClinicalTrials for Carcinoid Syndrome

Search NIH Clinical Center for Carcinoid Syndrome

Search CenterWatch for Carcinoid Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Carcinoid Syndrome

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Anatomical Context for Carcinoid Syndrome

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34MalaCards
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MalaCards organs/tissues related to Carcinoid Syndrome:

34
Lung, Heart, Colon, Small intestine, Appendix, Liver, Testes, Pituitary, Skin, Ovary, Testis, Cervix, Bone, Prostate, Pancreas, Thymus

Animal Models for Carcinoid Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Carcinoid Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3PYY, IGF1, NTS, NPY, TKT
2MP:00020068.2GAST, CALCA, MEN1, VEGFA, IGF1
3MP:00028737.9PYY, IGF1, VEGFA, SST, SYP, CALCA
4MP:00053897.8IGF1, VEGFA, CHGA, MEN1, HTR3A, GHRH
5MP:00053677.8IGF1, VEGFA, CHGA, HTR3A, CALCA, NPY
6MP:00053797.6IGF1, VEGFA, CHGA, MEN1, HTR3A, GHRH
7MP:00053787.0PYY, IGF1, VEGFA, CHGA, SST, MEN1
8MP:00053866.9PYY, VEGFA, SST, HTR3A, NTS, CALCA
9MP:00053766.1SST, CHGA, VEGFA, IGF1, PYY, MEN1
10MP:00036315.8TKT, PYY, IGF1, VEGFA, SST, MEN1

Publications for Carcinoid Syndrome

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53PubMed
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Articles related to Carcinoid Syndrome:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Cutaneous scleroderma and malignant carcinoid syndrome. (23517363)
2013
2
Primary neuroendocrine mediastinal tumor presenting with carcinoid syndrome and left supraclavicular lymphadenopathy: clinico-radiological and pathological features. (23771374)
2013
3
Carcinoid syndrome diagnosed by echocardiography. (19217173)
2011
4
Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome. (17011239)
2007
5
Carcinoid tumor and carcinoid syndrome. (17021482)
2003
6
(131)I-MIBG radionuclide therapy is safe and cost-effective in the control of symptoms of the carcinoid syndrome. (11417988)
2001
7
Prognostic value of heart rate variability analysis in patients with carcinoid syndrome. (11173898)
2001
8
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
9
Anesthesia for patients with carcinoid syndrome. (9444534)
1997
10
Obstructive sleep apnoea syndrome (OSAS) as a complication of carcinoid syndrome treated successfully by hepatic artery embolization. (9058639)
1997
11
Update on carcinoid syndrome. (9233098)
1997
12
Octreotide treatment of carcinoid syndrome: analysis of published dose-titration data. (8527614)
1995
13
Response to increasing doses of octreotide in a patient with carcinoid syndrome. (7509166)
1993
14
Carcinoid syndrome due to a primary ovarian carcinoid tumour. (8258808)
1993
15
Treatment of carcinoid syndrome with a somatostatin analogue]. (1372969)
1992
16
Chemotherapy responses in carcinoid syndrome. (1827797)
1991
17
Management of carcinoid syndrome. (1924020)
1991
18
POEMS syndrome with idiopathic flushing mimicking carcinoid syndrome. (2029023)
1991
19
Epidural anaesthesia for transurethral resection of the prostate in a patient with carcinoid syndrome. (2322971)
1990
20
Carcinoid syndrome without liver metastasis. (2602263)
1989
21
The carcinoid syndrome. (2457717)
1988
22
Carcinoids and carcinoid syndrome. (2884878)
1987
23
Use of a somatostatin analogue in association with surgery and hepatic arterial embolisation in the treatment of the carcinoid syndrome. (2893640)
1987
24
Somatostatin, anaesthesia, and the carcinoid syndrome. Peri-operative administration of a somatostatin analogue to suppress carcinoid tumour activity. (2887127)
1987
25
The carcinoid syndrome. (2875390)
1986
26
The carcinoid syndrome: palliation by hepatic artery embolization. (2424291)
1986
27
Carcinoid syndrome. Radiology. (3527315)
1986
28
The pentagastrin test in the diagnosis of the carcinoid syndrome. (2412067)
1985
29
On the mode of action of the pentagastrin test in the carcinoid syndrome. (4023617)
1985
30
Carcinoid tumors and carcinoid syndrome. (6592877)
1984
31
Carcinoid syndrome from gastrointestinal carcinoids without liver metastasis. (7092350)
1982
32
Anaesthesia and the carcinoid syndrome. (517724)
1979
33
Carcinoid syndrome and anaesthetic management. (509352)
1979
34
Carcinoid syndrome treated by hepatic embolization. (99001)
1978
35
Use of novel pharmacological agents in carcinoid syndrome: case report. (414163)
1977
36
Unilateral hypoperfusion of the lung and carcinoid syndrome due to bronchial carcinoid tumor. (842945)
1977
37
Blood prostaglandin activity associated with noradrenaline-provoked flush in the carcinoid syndrome. (4833791)
1974
38
Airways obstruction in the carcinoid syndrome. A study of the effect of drugs and other factors. I. Clinical and laboratory findings. (5041785)
1972
39
Cause of flushing in carcinoid syndrome. (4106630)
1971
40
Chest pain in the carcinoid syndrome. (4193351)
1970
41
Alterations of platelet ultrastructure in patients with carcinoid syndrome. (5822315)
1969
42
Gangrene of the small intestine in carcinoid syndrome. (5233491)
1967
43
Spontaneous abortion in the carcinoid syndrome. (5905051)
1966
44
Carcinoid syndrome associated with psychosis. (5827675)
1965
45
THE MALIGNANT CARCINOID SYNDROME. SYMPTOMS DUE TO HYPERSECRETION OF SEROTONIN. REPORT OF TWO CASES, ONE TREATED BY HEPATIC ARTERY PERFUSION. (14254630)
1965
46
APPENDICEAL CARCINOID WITH CARCINOID SYNDROME. (14166209)
1964
47
THE CARCINOID SYNDROME. (14267547)
1964
48
A malignant bronchial adenoma presenting as a carcinoid syndrome. (13994698)
1963
49
Carcinoid syndrome and hypertension. A case report. (13913540)
1962
50
Serotonin production by bronchial adenomas without the carcinoid syndrome. (14005020)
1961

Variations for Carcinoid Syndrome

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Expression for genes affiliated with Carcinoid Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carcinoid Syndrome

Search GEO for disease gene expression data for Carcinoid Syndrome.

Pathways for genes affiliated with Carcinoid Syndrome

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Carcinoid Syndrome

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46Novoseek, 30IUPHAR, 52PharmGKB, 3BitterDB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide469.7CALCA, SYP, SST, CHGA
2streptozotocin469.3SST, NPY, SYP, IFNA2, CHGA
3lanreotide46 3010.2GHRH, IGF1, CHGA, SST
4haloperidol46 52 30 3 1213.1NPY, SYP, CHGA, NTS, HTR3A, PYY
5yohimbine46 3 30 1212.0PYY, HTR3A, NTS, GAST, NPY
6oxyntomodulin46 6210.0NPY, GAST, NTS, SST, CHGA, PYY
7c-peptide468.8NTS, IGF1, PYY, SST, CHGA, GAST
8propranolol46 30 52 25 1212.8SST, HTR3A, GHRH, CALCA, GAST, CHGA
95-hydroxyindoleacetic acid46 259.7GAST, ENO2, HTR3A, SST, CHGA
10epinephrine46 25 1210.6CHGA, IFNA2, NPY, CALCA, NTS, SST
11mibg468.6CHGA, SST, CALCA, ENO2
12prostaglandin f2alpha468.6IGF1, NPY, CALCA, KNG1, SST
13carbachol46 30 1210.5SST, NTS, NPY, KNG1, GAST, CHGA
14clonidine46 52 30 1211.5NPY, CALCA, GHRH, PYY, IGF1, CHGA
15tetrodotoxin46 62 3010.4NTS, ENO2, NPY, CALCA, HTR3A, PYY
16gnrh468.3PYY, GAST, CHGA, SST, NTS, GHRH
17atropine46 30 1210.3NPY, GAST, CALCA, GHRH, NTS, SST
18nifedipine46 30 52 1211.2NPY, KNG1, NTS, GAST, TKT, GHRH
19isoproterenol46 129.2SST, NPY, GAST, KNG1, CHGA, NTS
20cyclic amp46 259.2CHGA, NTS, GHRH, SYP, CALCA, KNG1
21guanine46 25 1210.2SYP, UGT1A1, CALCA, NTS, CHGA, ENO2
22tamoxifen46 52 30 1211.1CHGA, IGF1, UGT1A1, VEGFA, IFNA2, GHRH
23thyroxine46 259.0UGT1A1, IGF1, SST, IFNA2, NTS, GHRH
24etoposide46 52 62 1211.0IFNA2, CHGA, ENO2, TKT, SYP, UGT1A1
25arginine467.9NPY, SST, CHGA, IGF1, UGT1A1, PYY
26indomethacin46 30 62 1210.9ENO2, NPY, KNG1, UGT1A1, IFNA2, NTS
27amine467.9UGT1A1, PYY, CHGA, HTR3A, NTS, ENO2
28forskolin46 52 129.8GHRH, NTS, CHGA, ENO2, SYP, CALCA
29paraffin467.5NPY, VEGFA, CHGA, NTS, SYP, ENO2
30histamine46 30 259.4CALCA, PYY, KNG1, GAST, NPY, SYP
31thymidine46 258.3GAST, ENO2, TKT, NTS, PYY, UGT1A1
32creatinine467.2IGF1, CHGA, SYP, CALCA, GAST, TKT
33gaba467.2TKT, PYY, CHGA, SST, HTR3A, NTS
34glutamate467.2GHRH, TKT, CHGA, NTS, SYP, GAST
35retinoic acid46 258.2CHGA, IGF1, UGT1A1, SST, IFNA2, SYP
36glucose467.2SST, GAST, NTS, NPY, PYY, ENO2
37cisplatin46 52 62 1210.1IFNA2, TKT, CHGA, HTR3A, VEGFA, UGT1A1
38acth467.0PYY, IGF1, SYP, GHRH, NTS, IFNA2
395-hydroxytryptamine466.9NPY, PYY, CHGA, SST, HTR3A, NTS
40acetylcholine46 52 30 25 1210.8SST, HTR3A, NTS, SYP, CALCA, KNG1
41adenylate466.8TKT, NPY, ENO2, GAST, KNG1, CALCA
42dexamethasone46 52 30 129.6SST, GAST, GHRH, HTR3A, CHGA, VEGFA
43vegf466.4TKT, CHGA, SYP, SST, IFNA2, MEN1
44testosterone46 62 25 129.4ENO2, NPY, TKT, GAST, UGT1A1, IGF1
45dopamine46 30 25 129.3PYY, IGF1, SST, ENO2, GAST, CALCA
46octreotide46 62 30 129.3NPY, ENO2, GAST, CALCA, GHRH, NTS
47calcium46 52 25 129.3GAST, ENO2, NPY, TKT, SYP, PYY
48norepinephrine46 25 128.2CHGA, PYY, SST, HTR3A, NTS, TKT
49estrogen465.5UGT1A1, IGF1, VEGFA, CHGA, MEN1, IFNA2
50tyrosine465.4IFNA2, GAST, KNG1, SYP, NTS, ENO2

GO Terms for genes affiliated with Carcinoid Syndrome

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17Gene Ontology
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Cellular components related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.9KNG1, VEGFA, IGF1
2extracellular spaceGO:0056156.6PYY, IGF1, VEGFA, SST, IFNA2, GHRH
3extracellular regionGO:0055766.1NPY, PYY, IGF1, VEGFA, CHGA, SST

Biological processes related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.7CHGA, CALCA, NPY
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6IGF1, GHRH
3feeding behaviorGO:0076319.6NPY, CALCA, PYY
4activation of protein kinase activityGO:0321479.5CALCA, VEGFA
5cell-cell signalingGO:0072679.4PYY, SST, IFNA2, GHRH, CALCA
6cellular component movementGO:0069289.3NPY, IGF1, PYY
7digestionGO:0075869.2NPY, HTR3A, SST, UGT1A1, PYY
8platelet degranulationGO:0025768.9KNG1, VEGFA, IGF1
9blood coagulationGO:0075968.3KNG1, IFNA2, VEGFA, IGF1

Molecular functions related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6NPY, NTS, PYY
2hormone activityGO:0051798.3GAST, CALCA, SST, IGF1, PYY

Products for genes affiliated with Carcinoid Syndrome

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Sources for Carcinoid Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet