MCID: CRC006
MIFTS: 60

Carcinoid Syndrome malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Carcinoid Syndrome

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NIH Rare Diseases:42 A carcinoid tumor is a rare, slow-growing cancer that usually starts in the lining of the digestive tract (appendix, stomach, small intestine, colon, rectum) or in the lungs but may occur elsewhere. because carcinoid tumors grow slowly and don't produce symptoms in the early stages, affected individuals may have the tumor for years before being diagnosed. in later stages the tumor sometimes produces hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for a carcinoid tumor. if it does not spread to other parts of the body, surgery can typically cure the cancer. last updated: 4/9/2012

MalaCards based summary: Carcinoid Syndrome, also known as carcinoid tumors, is related to pernicious anemia and atrophic gastritis. An important gene associated with Carcinoid Syndrome is SST (somatostatin), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and SIDS Susceptibility Pathways. The drug interferon alfa-2b and the compounds 111in-pentetreotide and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and colon, and related mouse phenotypes are adipose tissue and tumorigenesis.

MedlinePlus:33 Carcinoid tumors are rare, slow-growing cancers. they usually start in the lining of the digestive tract or in the lungs. they grow slowly and don't produce symptoms in the early stages. as a result, the average age of people diagnosed with digestive or lung carcinoids is about 60. in later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for carcinoid tumors. if they haven't spread to other parts of the body, surgery can cure the cancer.

Wikipedia:64 Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. The... more...

Aliases & Classifications for Carcinoid Syndrome

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Carcinoid Syndrome, Aliases & Descriptions:

Name: Carcinoid Syndrome 42
Carcinoid Tumors 33 61
Carcinoid Tumor 42 61
 
Malignant Carcinoid Syndrome 61
Carcinoid Tumor Syndrome 42
Carcinoid 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


External Ids:

ICD1026 E34.0

Related Diseases for Carcinoid Syndrome

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Diseases related to Carcinoid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 366)
idRelated DiseaseScoreTop Affiliating Genes
1pernicious anemia31.4GAST
2atrophic gastritis31.0CHGA, SST, MEN1, GAST
3granular cell tumor30.8ENO2, SYP
4apudoma30.7CALCA, SST
5constipation30.7PYY, HTR3A
6cushing's syndrome30.7SST, GHRH
7neuroendocrine tumor30.7CALCA, GHRH, CHGA, SST
8angiodysplasia30.6SST
9cholelithiasis30.6UGT1A1, SST
10sertoli cell tumor30.6SYP, ENO2
11zollinger-ellison syndrome30.5GAST, GHRH, MEN1, SST, CHGA
12neurofibromatosis30.5MEN1, ENO2, SST
13tubular adenocarcinoma30.5SYP, CHGA, ENO2
14acromegaly30.5IGF1, SST
15von hippel-lindau disease30.5NPY, VEGFA, MEN1
16hypercalcemia30.5MEN1, CALCA, GAST, CHGA
17ependymoma30.5SYP, MEN1, ENO2
18phaeochromocytoma30.4CHGA, NPY, CALCA
19neuroendocrine carcinoma30.4CHGA, SST, MEN1, SYP, ENO2, GAST
20multiple endocrine neoplasia30.4MEN1, CHGA, CALCA, GAST
21ganglioneuroblastoma30.3ENO2, NPY, SYP
22bipolar disorder30.3NPY, HTR3A
23diarrhea30.3UGT1A1, CHGA, HTR3A, PYY, CALCA, SST
24gastritis30.3CHGA, SST, GAST, NTS
25primary hyperparathyroidism30.3GAST, CALCA, MEN1, CHGA
26hyperparathyroidism30.3CALCA, CHGA, GAST, MEN1
27papillary thyroid carcinoma30.2TKT, MEN1, CALCA
28hypopituitarism30.2SST, IGF1, GHRH
29merkel cell carcinoma30.2SYP, ENO2, CHGA
30wermer syndrome30.1SST, MEN1, GAST, CHGA
31prolactinoma30.1SST, IGF1, CHGA, MEN1
32somatostatinoma30.1GAST, CALCA, GHRH, SST, CHGA
33lung cancer30.0GHRH, ENO2, SYP, VEGFA, CHGA
34vipoma30.0SST, GAST, GHRH, MEN1, NTS, CHGA
35gastrinoma30.0GAST, SYP, MEN1, SST, CHGA, ENO2
36hyperinsulinism30.0SST, IGF1, NPY
37paraganglioma30.0ENO2, GAST, CALCA, SYP, MEN1, SST
38dementia29.9SYP, KNG1, HTR3A
39neuroblastoma29.8KNG1, ENO2, SYP, NTS
40hyperthyroidism29.8IGF1, GHRH, NTS, SST
41prader-willi syndrome29.7IGF1, NPY, PYY
42hypoglycemia29.7IGF1, NPY, GAST, SST, CHGA, GHRH
43pituitary tumors29.7MEN1, GHRH, IGF1, CHGA, SST
44hypertension29.7IGF1, NPY, KNG1, CALCA
45pituitary adenoma29.6SYP, NTS, SST, CHGA, IGF1, MEN1
46hyperglycemia29.4TKT, NPY, GHRH, SST, IGF1, PYY
47adenoma29.4GHRH, SYP, SST, CHGA, IGF1, PYY
48obesity29.3NTS, PYY, IGF1, GHRH, KNG1, NPY
49colorectal cancer29.1IFNA2, VEGFA, IGF1, NTS, UGT1A1, TKT
50pheochromocytoma29.1SYP, NTS, MEN1, SST, CHGA, PYY

Graphical network of the top 20 diseases related to Carcinoid Syndrome:



Diseases related to carcinoid syndrome

Symptoms for Carcinoid Syndrome

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Drugs & Therapeutics for Carcinoid Syndrome

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Drug clinical trials:

Search ClinicalTrials for Carcinoid Syndrome

Search NIH Clinical Center for Carcinoid Syndrome

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Carcinoid Syndrome

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Anatomical Context for Carcinoid Syndrome

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MalaCards organs/tissues related to Carcinoid Syndrome:

32
Lung, Heart, Colon, Small intestine, Appendix, Liver, Skin, Testes, Pituitary, Bone, Ovary, Testis, Cervix, Thymus, Pancreas, Prostate

Animal Models for Carcinoid Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Carcinoid Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3PYY, IGF1, NTS, NPY, TKT
2MP:00020068.2GAST, CALCA, MEN1, VEGFA, IGF1
3MP:00028737.9PYY, IGF1, VEGFA, SST, SYP, CALCA
4MP:00053897.8IGF1, VEGFA, CHGA, MEN1, HTR3A, GHRH
5MP:00053677.8IGF1, VEGFA, CHGA, HTR3A, CALCA, NPY
6MP:00053797.6IGF1, VEGFA, CHGA, MEN1, HTR3A, GHRH
7MP:00053787.0PYY, IGF1, VEGFA, CHGA, SST, MEN1
8MP:00053866.9PYY, VEGFA, SST, HTR3A, NTS, CALCA
9MP:00053766.1SST, CHGA, VEGFA, IGF1, PYY, MEN1
10MP:00036315.8TKT, PYY, IGF1, VEGFA, SST, MEN1

Publications for Carcinoid Syndrome

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Articles related to Carcinoid Syndrome:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide. (25012985)
2014
2
Cutaneous scleroderma and malignant carcinoid syndrome. (23517363)
2013
3
Primary neuroendocrine mediastinal tumor presenting with carcinoid syndrome and left supraclavicular lymphadenopathy: clinico-radiological and pathological features. (23771374)
2013
4
Carcinoid syndrome diagnosed by echocardiography. (19217173)
2011
5
Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome. (17011239)
2007
6
Carcinoid tumor and carcinoid syndrome. (17021482)
2003
7
(131)I-MIBG radionuclide therapy is safe and cost-effective in the control of symptoms of the carcinoid syndrome. (11417988)
2001
8
Prognostic value of heart rate variability analysis in patients with carcinoid syndrome. (11173898)
2001
9
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
10
Anesthesia for patients with carcinoid syndrome. (9444534)
1997
11
Obstructive sleep apnoea syndrome (OSAS) as a complication of carcinoid syndrome treated successfully by hepatic artery embolization. (9058639)
1997
12
Update on carcinoid syndrome. (9233098)
1997
13
Octreotide treatment of carcinoid syndrome: analysis of published dose-titration data. (8527614)
1995
14
Response to increasing doses of octreotide in a patient with carcinoid syndrome. (7509166)
1993
15
Carcinoid syndrome due to a primary ovarian carcinoid tumour. (8258808)
1993
16
Treatment of carcinoid syndrome with a somatostatin analogue]. (1372969)
1992
17
Chemotherapy responses in carcinoid syndrome. (1827797)
1991
18
Management of carcinoid syndrome. (1924020)
1991
19
POEMS syndrome with idiopathic flushing mimicking carcinoid syndrome. (2029023)
1991
20
Epidural anaesthesia for transurethral resection of the prostate in a patient with carcinoid syndrome. (2322971)
1990
21
Carcinoid syndrome without liver metastasis. (2602263)
1989
22
The carcinoid syndrome. (2457717)
1988
23
Carcinoids and carcinoid syndrome. (2884878)
1987
24
Use of a somatostatin analogue in association with surgery and hepatic arterial embolisation in the treatment of the carcinoid syndrome. (2893640)
1987
25
Somatostatin, anaesthesia, and the carcinoid syndrome. Peri-operative administration of a somatostatin analogue to suppress carcinoid tumour activity. (2887127)
1987
26
The carcinoid syndrome. (2875390)
1986
27
The carcinoid syndrome: palliation by hepatic artery embolization. (2424291)
1986
28
Carcinoid syndrome. Radiology. (3527315)
1986
29
The pentagastrin test in the diagnosis of the carcinoid syndrome. (2412067)
1985
30
On the mode of action of the pentagastrin test in the carcinoid syndrome. (4023617)
1985
31
Carcinoid tumors and carcinoid syndrome. (6592877)
1984
32
Carcinoid syndrome from gastrointestinal carcinoids without liver metastasis. (7092350)
1982
33
Anaesthesia and the carcinoid syndrome. (517724)
1979
34
Carcinoid syndrome and anaesthetic management. (509352)
1979
35
Carcinoid syndrome treated by hepatic embolization. (99001)
1978
36
Use of novel pharmacological agents in carcinoid syndrome: case report. (414163)
1977
37
Unilateral hypoperfusion of the lung and carcinoid syndrome due to bronchial carcinoid tumor. (842945)
1977
38
Blood prostaglandin activity associated with noradrenaline-provoked flush in the carcinoid syndrome. (4833791)
1974
39
Airways obstruction in the carcinoid syndrome. A study of the effect of drugs and other factors. I. Clinical and laboratory findings. (5041785)
1972
40
Cause of flushing in carcinoid syndrome. (4106630)
1971
41
Chest pain in the carcinoid syndrome. (4193351)
1970
42
Alterations of platelet ultrastructure in patients with carcinoid syndrome. (5822315)
1969
43
Gangrene of the small intestine in carcinoid syndrome. (5233491)
1967
44
Carcinoid syndrome associated with psychosis. (5827675)
1965
45
THE MALIGNANT CARCINOID SYNDROME. SYMPTOMS DUE TO HYPERSECRETION OF SEROTONIN. REPORT OF TWO CASES, ONE TREATED BY HEPATIC ARTERY PERFUSION. (14254630)
1965
46
APPENDICEAL CARCINOID WITH CARCINOID SYNDROME. (14166209)
1964
47
THE CARCINOID SYNDROME. (14267547)
1964
48
A malignant bronchial adenoma presenting as a carcinoid syndrome. (13994698)
1963
49
Carcinoid syndrome and hypertension. A case report. (13913540)
1962
50
Serotonin production by bronchial adenomas without the carcinoid syndrome. (14005020)
1961

Variations for Carcinoid Syndrome

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Expression for genes affiliated with Carcinoid Syndrome

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Expression patterns in normal tissues for genes affiliated with Carcinoid Syndrome

Search GEO for disease gene expression data for Carcinoid Syndrome.

Pathways for genes affiliated with Carcinoid Syndrome

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Compounds for genes affiliated with Carcinoid Syndrome

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Compounds related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide449.7CALCA, SYP, SST, CHGA
2streptozotocin449.3SST, NPY, SYP, IFNA2, CHGA
3lanreotide44 2910.2GHRH, IGF1, CHGA, SST
4haloperidol44 50 29 3 1213.1NPY, SYP, CHGA, NTS, HTR3A, PYY
5yohimbine44 3 29 1212.0PYY, HTR3A, NTS, GAST, NPY
6oxyntomodulin44 6010.0NPY, GAST, NTS, SST, CHGA, PYY
7c-peptide448.8NTS, IGF1, PYY, SST, CHGA, GAST
8propranolol44 29 50 25 1212.8SST, HTR3A, GHRH, CALCA, GAST, CHGA
95-hydroxyindoleacetic acid44 259.7GAST, ENO2, HTR3A, SST, CHGA
10epinephrine44 25 1210.6CHGA, IFNA2, NPY, CALCA, NTS, SST
11mibg448.6CHGA, SST, CALCA, ENO2
12prostaglandin f2alpha448.6IGF1, NPY, CALCA, KNG1, SST
13carbachol44 29 1210.5SST, NTS, NPY, KNG1, GAST, CHGA
14clonidine44 50 29 1211.5NPY, CALCA, GHRH, PYY, IGF1, CHGA
15tetrodotoxin44 60 2910.4NTS, ENO2, NPY, CALCA, HTR3A, PYY
16gnrh448.3PYY, GAST, CHGA, SST, NTS, GHRH
17atropine44 29 1210.3NPY, GAST, CALCA, GHRH, NTS, SST
18nifedipine44 29 50 1211.2NPY, KNG1, NTS, GAST, TKT, GHRH
19isoproterenol44 129.2SST, NPY, GAST, KNG1, CHGA, NTS
20cyclic amp44 259.2CHGA, NTS, GHRH, SYP, CALCA, KNG1
21guanine44 25 1210.2SYP, UGT1A1, CALCA, NTS, CHGA, ENO2
22tamoxifen44 50 29 1211.1CHGA, IGF1, UGT1A1, VEGFA, IFNA2, GHRH
23thyroxine44 259.0UGT1A1, IGF1, SST, IFNA2, NTS, GHRH
24etoposide44 50 60 1211.0IFNA2, CHGA, ENO2, TKT, SYP, UGT1A1
25arginine447.9NPY, SST, CHGA, IGF1, UGT1A1, PYY
26indomethacin44 29 60 1210.9ENO2, NPY, KNG1, UGT1A1, IFNA2, NTS
27amine447.9UGT1A1, PYY, CHGA, HTR3A, NTS, ENO2
28forskolin44 50 129.8GHRH, NTS, CHGA, ENO2, SYP, CALCA
29paraffin447.5NPY, VEGFA, CHGA, NTS, SYP, ENO2
30histamine44 29 259.4CALCA, PYY, KNG1, GAST, NPY, SYP
31thymidine44 258.3GAST, ENO2, TKT, NTS, PYY, UGT1A1
32creatinine447.2IGF1, CHGA, SYP, CALCA, GAST, TKT
33gaba447.2TKT, PYY, CHGA, SST, HTR3A, NTS
34glutamate447.2GHRH, TKT, CHGA, NTS, SYP, GAST
35retinoic acid44 258.2CHGA, IGF1, UGT1A1, SST, IFNA2, SYP
36glucose447.2SST, GAST, NTS, NPY, PYY, ENO2
37cisplatin44 50 60 1210.1IFNA2, TKT, CHGA, HTR3A, VEGFA, UGT1A1
38acth447.0PYY, IGF1, SYP, GHRH, NTS, IFNA2
395-hydroxytryptamine446.9NPY, PYY, CHGA, SST, HTR3A, NTS
40acetylcholine44 50 29 25 1210.8SST, HTR3A, NTS, SYP, CALCA, KNG1
41adenylate446.8TKT, NPY, ENO2, GAST, KNG1, CALCA
42dexamethasone44 50 29 129.6SST, GAST, GHRH, HTR3A, CHGA, VEGFA
43vegf446.4TKT, CHGA, SYP, SST, IFNA2, MEN1
44testosterone44 60 25 129.4ENO2, NPY, TKT, GAST, UGT1A1, IGF1
45dopamine44 29 25 129.3PYY, IGF1, SST, ENO2, GAST, CALCA
46octreotide44 60 29 129.3NPY, ENO2, GAST, CALCA, GHRH, NTS
47calcium44 50 25 129.3GAST, ENO2, NPY, TKT, SYP, PYY
48norepinephrine44 25 128.2CHGA, PYY, SST, HTR3A, NTS, TKT
49estrogen445.5UGT1A1, IGF1, VEGFA, CHGA, MEN1, IFNA2
50tyrosine445.4IFNA2, GAST, KNG1, SYP, NTS, ENO2

GO Terms for genes affiliated with Carcinoid Syndrome

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Cellular components related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.9KNG1, VEGFA, IGF1
2extracellular spaceGO:0056156.6PYY, IGF1, VEGFA, SST, IFNA2, GHRH
3extracellular regionGO:0055766.1NPY, PYY, IGF1, VEGFA, CHGA, SST

Biological processes related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.7CHGA, CALCA, NPY
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6IGF1, GHRH
3feeding behaviorGO:0076319.6NPY, CALCA, PYY
4activation of protein kinase activityGO:0321479.5CALCA, VEGFA
5cell-cell signalingGO:0072679.4PYY, SST, IFNA2, GHRH, CALCA
6cellular component movementGO:0069289.3NPY, IGF1, PYY
7digestionGO:0075869.2NPY, HTR3A, SST, UGT1A1, PYY
8platelet degranulationGO:0025768.9KNG1, VEGFA, IGF1
9blood coagulationGO:0075968.3KNG1, IFNA2, VEGFA, IGF1

Molecular functions related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6NPY, NTS, PYY
2hormone activityGO:0051798.3GAST, CALCA, SST, IGF1, PYY

Products for genes affiliated with Carcinoid Syndrome

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Sources for Carcinoid Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet