MCID: CRC006
MIFTS: 62

Carcinoid Syndrome malady

Rare diseases, Endocrine diseases, Neuronal diseases, Cancer diseases categories

Summaries for Carcinoid Syndrome

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NIH Rare Diseases:43 A carcinoid tumor is a rare, slow-growing cancer that usually starts in the lining of the digestive tract (appendix, stomach, small intestine, colon, rectum) or in the lungs but may occur elsewhere. because carcinoid tumors grow slowly and don't produce symptoms in the early stages, affected individuals may have the tumor for years before being diagnosed. in later stages the tumor sometimes produces hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for a carcinoid tumor. if it does not spread to other parts of the body, surgery can typically cure the cancer. last updated: 4/9/2012

MalaCards based summary: Carcinoid Syndrome, also known as carcinoid tumors, is related to apudoma and diarrhea. An important gene associated with Carcinoid Syndrome is SST (somatostatin), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and SIDS Susceptibility Pathways. The drug interferon alfa-2b and the compounds 111in-pentetreotide and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and colon, and related mouse phenotypes are adipose tissue and tumorigenesis.

MedlinePlus:34 Carcinoid tumors are rare, slow-growing cancers. they usually start in the lining of the digestive tract or in the lungs. they grow slowly and don't produce symptoms in the early stages. as a result, the average age of people diagnosed with digestive or lung carcinoids is about 60. in later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for carcinoid tumors. if they haven't spread to other parts of the body, surgery can cure the cancer.

Wikipedia:65 Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. The... more...

Aliases & Classifications for Carcinoid Syndrome

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Carcinoid Syndrome, Aliases & Descriptions:

Name: Carcinoid Syndrome 43
Carcinoid Tumors 34 62
Carcinoid Tumor 43 62
Malignant Carcinoid Syndrome 62
Carcinoid Tumor Syndrome 43
 
Neuroendocrine Tumor 43
Endocrine Tumor 43
Carcinoid 45
Apudoma 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases, Neuronal diseases


External Ids:

ICD1027 E34.0

Related Diseases for Carcinoid Syndrome

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Diseases related to Carcinoid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 436)
idRelated DiseaseScoreTop Affiliating Genes
1apudoma31.3SST, CALCA
2diarrhea30.6PYY, UGT1A1, CHGA, SST, HTR3A, CALCA
3adenoma30.5GAST, CALCA, SYP, GHRH, NTS, MEN1
4prostate cancer30.4ENO2, GHRH, NTS, CHGA, IGF1
5neuroendocrine tumor30.3CALCA, GHRH, SST, CHGA
6zollinger-ellison syndrome30.3GAST, GHRH, MEN1, SST, CHGA
7granular cell tumor30.3SYP, ENO2
8constipation30.3PYY, HTR3A
9pituitary adenoma30.3IGF1, CHGA, SST, MEN1, NTS, GHRH
10acinar cell carcinoma30.3GAST, CHGA
11pancreatic cancer30.2PYY, SST, NTS, GAST
12von hippel-lindau syndrome30.2VEGFA, MEN1, NPY
13neuroblastoma30.2NTS, SYP, KNG1, ENO2
14multiple endocrine neoplasia30.2CHGA, MEN1, CALCA, GAST
15acromegaly30.2GHRH, MEN1, SST, IGF1
16glioblastoma30.2VEGFA, GHRH, KNG1, TKT
17neurofibromatosis30.1SST, MEN1, ENO2
18endocrine gland cancer30.1CHGA, SST, SYP, GAST
19hyperparathyroidism30.1CHGA, MEN1, CALCA, GAST
20hypoglycemia30.1IGF1, CHGA, SST, GHRH, GAST, NPY
21thyroid cancer30.1CHGA, SST, CALCA, TKT
22cholelithiasis30.1UGT1A1, SST
23sertoli cell tumor30.1SYP, ENO2
24prolactinoma30.1IGF1, CHGA, SST, MEN1
25pernicious anemia30.1GAST
26tubular adenocarcinoma30.1CHGA, SYP, ENO2
27ganglioneuroblastoma30.1SYP, ENO2, NPY
28hypopituitarism30.0IGF1, SST, GHRH
29ependymoma30.0MEN1, SYP, ENO2
30cushing's syndrome30.0SST, GHRH
31hemangioma30.0IFNA2, MEN1, VEGFA
32esophagitis30.0NTS, GAST
33phaeochromocytoma30.0CHGA, CALCA, NPY
34pheochromocytoma30.0MEN1, SST, CHGA, PYY, NPY, ENO2
35glucagonoma30.0CHGA, SST, MEN1, GHRH, GAST, ENO2
36vipoma30.0SST, CALCA
37lung cancer30.0VEGFA, CHGA, SYP, ENO2
38bipolar disorder30.0HTR3A, NPY
39gastritis30.0CHGA, SST, NTS, GAST
40osteoporosis29.9NPY, CALCA, IGF1
41somatostatinoma29.9GAST, CALCA, GHRH, SST, CHGA
42hyperinsulinism29.9NPY, SST, IGF1
43islet cell tumor29.9SST, GAST
44dementia29.9KNG1, SYP, HTR3A
45hyperinsulinemic hypoglycemia29.9SST, GAST
46merkel cell carcinoma29.9CHGA, SYP, ENO2
47duodenal ulcer29.9SST, GAST
48parathyroid adenoma29.9CHGA, MEN1, CALCA
49atrophic gastritis29.9CHGA, SST, MEN1, GAST
50multiple endocrine neoplasia 129.9CHGA, SST, MEN1, GAST

Graphical network of the top 20 diseases related to Carcinoid Syndrome:



Diseases related to carcinoid syndrome

Symptoms for Carcinoid Syndrome

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Drugs & Therapeutics for Carcinoid Syndrome

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Drug clinical trials:

Search ClinicalTrials for Carcinoid Syndrome

Search NIH Clinical Center for Carcinoid Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Carcinoid Syndrome

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Anatomical Context for Carcinoid Syndrome

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MalaCards organs/tissues related to Carcinoid Syndrome:

33
Lung, Heart, Colon, Small intestine, Appendix, Liver, Skin, Testes, Pituitary, Bone, Ovary, Testis, Cervix, Thymus, Pancreas, Prostate

Animal Models for Carcinoid Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Carcinoid Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3PYY, IGF1, NTS, NPY, TKT
2MP:00020068.2GAST, CALCA, MEN1, VEGFA, IGF1
3MP:00028737.9PYY, IGF1, VEGFA, SST, SYP, CALCA
4MP:00053897.8IGF1, VEGFA, CHGA, MEN1, HTR3A, GHRH
5MP:00053677.8IGF1, VEGFA, CHGA, HTR3A, CALCA, NPY
6MP:00053797.6IGF1, VEGFA, CHGA, MEN1, HTR3A, GHRH
7MP:00053787.0PYY, IGF1, VEGFA, CHGA, SST, MEN1
8MP:00053866.9PYY, VEGFA, SST, HTR3A, NTS, CALCA
9MP:00053766.1SST, CHGA, VEGFA, IGF1, PYY, MEN1
10MP:00036315.8TKT, PYY, IGF1, VEGFA, SST, MEN1

Publications for Carcinoid Syndrome

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Articles related to Carcinoid Syndrome:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide. (25012985)
2014
2
Cutaneous scleroderma and malignant carcinoid syndrome. (23517363)
2013
3
Primary neuroendocrine mediastinal tumor presenting with carcinoid syndrome and left supraclavicular lymphadenopathy: clinico-radiological and pathological features. (23771374)
2013
4
Carcinoid syndrome diagnosed by echocardiography. (19217173)
2011
5
Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome. (17011239)
2007
6
Carcinoid tumor and carcinoid syndrome. (17021482)
2003
7
(131)I-MIBG radionuclide therapy is safe and cost-effective in the control of symptoms of the carcinoid syndrome. (11417988)
2001
8
Prognostic value of heart rate variability analysis in patients with carcinoid syndrome. (11173898)
2001
9
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
10
Anesthesia for patients with carcinoid syndrome. (9444534)
1997
11
Obstructive sleep apnoea syndrome (OSAS) as a complication of carcinoid syndrome treated successfully by hepatic artery embolization. (9058639)
1997
12
Update on carcinoid syndrome. (9233098)
1997
13
Octreotide treatment of carcinoid syndrome: analysis of published dose-titration data. (8527614)
1995
14
Response to increasing doses of octreotide in a patient with carcinoid syndrome. (7509166)
1993
15
Carcinoid syndrome due to a primary ovarian carcinoid tumour. (8258808)
1993
16
Treatment of carcinoid syndrome with a somatostatin analogue]. (1372969)
1992
17
Chemotherapy responses in carcinoid syndrome. (1827797)
1991
18
Management of carcinoid syndrome. (1924020)
1991
19
POEMS syndrome with idiopathic flushing mimicking carcinoid syndrome. (2029023)
1991
20
Epidural anaesthesia for transurethral resection of the prostate in a patient with carcinoid syndrome. (2322971)
1990
21
Carcinoid syndrome without liver metastasis. (2602263)
1989
22
The carcinoid syndrome. (2457717)
1988
23
Carcinoids and carcinoid syndrome. (2884878)
1987
24
Use of a somatostatin analogue in association with surgery and hepatic arterial embolisation in the treatment of the carcinoid syndrome. (2893640)
1987
25
Somatostatin, anaesthesia, and the carcinoid syndrome. Peri-operative administration of a somatostatin analogue to suppress carcinoid tumour activity. (2887127)
1987
26
The carcinoid syndrome. (2875390)
1986
27
The carcinoid syndrome: palliation by hepatic artery embolization. (2424291)
1986
28
Carcinoid syndrome. Radiology. (3527315)
1986
29
The pentagastrin test in the diagnosis of the carcinoid syndrome. (2412067)
1985
30
On the mode of action of the pentagastrin test in the carcinoid syndrome. (4023617)
1985
31
Carcinoid tumors and carcinoid syndrome. (6592877)
1984
32
Carcinoid syndrome from gastrointestinal carcinoids without liver metastasis. (7092350)
1982
33
Anaesthesia and the carcinoid syndrome. (517724)
1979
34
Carcinoid syndrome and anaesthetic management. (509352)
1979
35
Carcinoid syndrome treated by hepatic embolization. (99001)
1978
36
Use of novel pharmacological agents in carcinoid syndrome: case report. (414163)
1977
37
Unilateral hypoperfusion of the lung and carcinoid syndrome due to bronchial carcinoid tumor. (842945)
1977
38
Blood prostaglandin activity associated with noradrenaline-provoked flush in the carcinoid syndrome. (4833791)
1974
39
Airways obstruction in the carcinoid syndrome. A study of the effect of drugs and other factors. I. Clinical and laboratory findings. (5041785)
1972
40
Cause of flushing in carcinoid syndrome. (4106630)
1971
41
Chest pain in the carcinoid syndrome. (4193351)
1970
42
Alterations of platelet ultrastructure in patients with carcinoid syndrome. (5822315)
1969
43
Gangrene of the small intestine in carcinoid syndrome. (5233491)
1967
44
Carcinoid syndrome associated with psychosis. (5827675)
1965
45
THE MALIGNANT CARCINOID SYNDROME. SYMPTOMS DUE TO HYPERSECRETION OF SEROTONIN. REPORT OF TWO CASES, ONE TREATED BY HEPATIC ARTERY PERFUSION. (14254630)
1965
46
APPENDICEAL CARCINOID WITH CARCINOID SYNDROME. (14166209)
1964
47
THE CARCINOID SYNDROME. (14267547)
1964
48
A malignant bronchial adenoma presenting as a carcinoid syndrome. (13994698)
1963
49
Carcinoid syndrome and hypertension. A case report. (13913540)
1962
50
Serotonin production by bronchial adenomas without the carcinoid syndrome. (14005020)
1961

Variations for Carcinoid Syndrome

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Expression for genes affiliated with Carcinoid Syndrome

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Search GEO for disease gene expression data for Carcinoid Syndrome.

Pathways for genes affiliated with Carcinoid Syndrome

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Compounds for genes affiliated with Carcinoid Syndrome

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Compounds related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide459.7CALCA, SYP, SST, CHGA
2streptozotocin459.3SST, NPY, SYP, IFNA2, CHGA
3lanreotide45 3010.2GHRH, IGF1, CHGA, SST
4haloperidol45 51 30 3 1313.1NPY, SYP, CHGA, NTS, HTR3A, PYY
5yohimbine45 3 30 1312.0PYY, HTR3A, NTS, GAST, NPY
6oxyntomodulin45 6110.0NPY, GAST, NTS, SST, CHGA, PYY
7c-peptide458.8NTS, IGF1, PYY, SST, CHGA, GAST
8propranolol45 30 51 26 1312.8SST, HTR3A, GHRH, CALCA, GAST, CHGA
95-hydroxyindoleacetic acid45 269.7GAST, ENO2, HTR3A, SST, CHGA
10epinephrine45 26 1310.6CHGA, IFNA2, NPY, CALCA, NTS, SST
11mibg458.6CHGA, SST, CALCA, ENO2
12prostaglandin f2alpha458.6IGF1, NPY, CALCA, KNG1, SST
13carbachol45 30 1310.5SST, NTS, NPY, KNG1, GAST, CHGA
14clonidine45 51 30 1311.5NPY, CALCA, GHRH, PYY, IGF1, CHGA
15tetrodotoxin45 61 3010.4NTS, ENO2, NPY, CALCA, HTR3A, PYY
16gnrh458.3PYY, GAST, CHGA, SST, NTS, GHRH
17atropine45 30 1310.3NPY, GAST, CALCA, GHRH, NTS, SST
18nifedipine45 30 51 1311.2NPY, KNG1, NTS, GAST, TKT, GHRH
19isoproterenol45 139.2SST, NPY, GAST, KNG1, CHGA, NTS
20cyclic amp45 269.2CHGA, NTS, GHRH, SYP, CALCA, KNG1
21guanine45 26 1310.2SYP, UGT1A1, CALCA, NTS, CHGA, ENO2
22tamoxifen45 51 30 1311.1CHGA, IGF1, UGT1A1, VEGFA, IFNA2, GHRH
23thyroxine45 269.0UGT1A1, IGF1, SST, IFNA2, NTS, GHRH
24etoposide45 51 61 1311.0IFNA2, CHGA, ENO2, TKT, SYP, UGT1A1
25arginine457.9NPY, SST, CHGA, IGF1, UGT1A1, PYY
26indomethacin45 30 61 1310.9ENO2, NPY, KNG1, UGT1A1, IFNA2, NTS
27amine457.9UGT1A1, PYY, CHGA, HTR3A, NTS, ENO2
28forskolin45 51 139.8GHRH, NTS, CHGA, ENO2, SYP, CALCA
29paraffin457.5NPY, VEGFA, CHGA, NTS, SYP, ENO2
30histamine45 30 269.4CALCA, PYY, KNG1, GAST, NPY, SYP
31thymidine45 268.3GAST, ENO2, TKT, NTS, PYY, UGT1A1
32creatinine457.2IGF1, CHGA, SYP, CALCA, GAST, TKT
33gaba457.2TKT, PYY, CHGA, SST, HTR3A, NTS
34glutamate457.2GHRH, TKT, CHGA, NTS, SYP, GAST
35retinoic acid45 268.2CHGA, IGF1, UGT1A1, SST, IFNA2, SYP
36glucose457.2SST, GAST, NTS, NPY, PYY, ENO2
37cisplatin45 51 61 1310.1IFNA2, TKT, CHGA, HTR3A, VEGFA, UGT1A1
38acth457.0PYY, IGF1, SYP, GHRH, NTS, IFNA2
395-hydroxytryptamine456.9NPY, PYY, CHGA, SST, HTR3A, NTS
40acetylcholine45 51 30 26 1310.8SST, HTR3A, NTS, SYP, CALCA, KNG1
41adenylate456.8TKT, NPY, ENO2, GAST, KNG1, CALCA
42dexamethasone45 51 30 139.6SST, GAST, GHRH, HTR3A, CHGA, VEGFA
43vegf456.4TKT, CHGA, SYP, SST, IFNA2, MEN1
44testosterone45 61 26 139.4ENO2, NPY, TKT, GAST, UGT1A1, IGF1
45dopamine45 30 26 139.3PYY, IGF1, SST, ENO2, GAST, CALCA
46octreotide45 61 30 139.3NPY, ENO2, GAST, CALCA, GHRH, NTS
47calcium45 51 26 139.3GAST, ENO2, NPY, TKT, SYP, PYY
48norepinephrine45 26 138.2CHGA, PYY, SST, HTR3A, NTS, TKT
49estrogen455.5UGT1A1, IGF1, VEGFA, CHGA, MEN1, IFNA2
50tyrosine455.4IFNA2, GAST, KNG1, SYP, NTS, ENO2

GO Terms for genes affiliated with Carcinoid Syndrome

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Cellular components related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310938.9KNG1, VEGFA, IGF1
2extracellular spaceGO:00056156.6PYY, IGF1, VEGFA, SST, IFNA2, GHRH
3extracellular regionGO:00055766.1NPY, PYY, IGF1, VEGFA, CHGA, SST

Biological processes related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00082179.7CHGA, CALCA, NPY
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.6IGF1, GHRH
3feeding behaviorGO:00076319.6NPY, CALCA, PYY
4activation of protein kinase activityGO:00321479.5CALCA, VEGFA
5cell-cell signalingGO:00072679.4PYY, SST, IFNA2, GHRH, CALCA
6cellular component movementGO:00069289.3NPY, IGF1, PYY
7digestionGO:00075869.2NPY, HTR3A, SST, UGT1A1, PYY
8platelet degranulationGO:00025768.9KNG1, VEGFA, IGF1
9blood coagulationGO:00075968.3KNG1, IFNA2, VEGFA, IGF1

Molecular functions related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.6NPY, NTS, PYY
2hormone activityGO:00051798.3GAST, CALCA, SST, IGF1, PYY

Products for genes affiliated with Carcinoid Syndrome

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Sources for Carcinoid Syndrome

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet