MCID: CRC006
MIFTS: 46

Carcinoid Syndrome malady

Endocrine diseases, Cancer diseases categories

Summaries for Carcinoid Syndrome

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A carcinoid tumor is a rare, slow-growing cancer that usually starts in the lining of the digestive tract (appendix, stomach, small intestine, colon, rectum) or in the lungs but may occur elsewhere. because carcinoid tumors grow slowly and don't produce symptoms in the early stages, affected individuals may have the tumor for years before being diagnosed. in later stages the tumor sometimes produces hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for a carcinoid tumor. if it does not spread to other parts of the body, surgery can typically cure the cancer. last updated: 4/9/2012

MalaCards: Carcinoid Syndrome, also known as carcinoid tumor, is related to hepatitis and adenoma. An important gene associated with Carcinoid Syndrome is SST (somatostatin), and among its related pathways are G alpha (q) signalling events and Class A/1 (Rhodopsin-like receptors). The drug interferon alfa-2b and the compounds estrogen and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and small intestine, and related mouse phenotypes are renal/urinary system and nervous system.

MedlinePlus:33 Carcinoid tumors are rare, slow-growing cancers. they usually start in the lining of the digestive tract or in the lungs. they grow slowly and don't produce symptoms in the early stages. as a result, the average age of people diagnosed with digestive or lung carcinoids is about 60. in later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. the syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing. surgery is the main treatment for carcinoid tumors. if they haven't spread to other parts of the body, surgery can cure the cancer.

Wikipedia:63 Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. The... more...

Aliases & Classifications for Carcinoid Syndrome

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Sources:
42NIH Rare Diseases, 60UMLS, 44Novoseek, 33MedlinePlus, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

carcinoid syndrome 42
carcinoid tumor 42 60
malignant carcinoid syndrome 60
carcinoid tumor syndrome 42
carcinoid tumors 33
carcinoid 44


External Ids:

ICD1025 E34.0

Related Diseases for Carcinoid Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Carcinoid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 386)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.9IFNA2, UGT1A1
2adenoma30.5CALCA, PYY, GAST, MEN1, GHRH, SYP
3pernicious anemia30.5GAST
4atrophic gastritis30.5MEN1, GAST, CHGA, SST
5thyroiditis30.4CALCA
6diarrhea30.4UGT1A1, MLN, CHGA, SST, TAC1, GAST
7pancreatitis30.3PPY, TAC1, SST
8lung cancer30.2ENO2, SYP, GHRH, CHGA
9neuroendocrine tumor30.2CALCA, PPY, GHRH, CHGA, SST
10zollinger-ellison syndrome30.2MEN1, SST, CHGA, GAST, GHRH
11von hippel-lindau disease30.1NPY, MEN1
12granular cell tumor30.1SYP, ENO2
13gallbladder disease30.1MLN, PYY
14hypercalcemia30.1MEN1, CHGA, GAST, CALCA
15constipation30.1PYY, HTR3A, MLN, TAC1
16thyroid medullary carcinoma30.1ENO2, CHGA, SST, NTS, MEN1, CALCA
17lung small cell carcinoma30.1ENO2, MEN1, CALCA, TAC1, GAST, SYP
18duodenitis30.0GAST
19acromegaly30.0MEN1, GHRH, SST
20hypertension30.0NPY, CALCA, TAC1
21hypoglycemia30.0MLN, SST, NPY, PPY, GAST, CHGA
22pheochromocytoma30.0CHGA, NPY, CALCA, PYY, MEN1, MLN
23large cell carcinoma30.0ENO2, SYP, CHGA
24phaeochromocytoma30.0NPY, CHGA, CALCA
25morbid obesity29.9PYY
26sarcoma29.9ENO2
27cholelithiasis29.9SST, UGT1A1
28deficiency anemia29.9IFNA2, GHRH
29islet cell tumor29.9SST, GAST
30tubular adenocarcinoma29.9SYP, CHGA, ENO2
31neurofibromatosis29.9MEN1, SST, ENO2
32prolactinoma29.9MEN1, SST, CHGA
33ganglioneuroblastoma29.9NPY, SYP, ENO2
34papillary carcinoma29.9CALCA, SYP, CHGA
35pancreatic cancer29.9PYY, GAST, NTS, SST
36primary hyperparathyroidism29.9CALCA, MEN1, CHGA, GAST
37hyperparathyroidism29.9GAST, CALCA, CHGA, MEN1
38obesity29.9NPY, MLN, PYY, NTS, GHRH
39gastrinoma29.9ENO2, SST, MEN1, GAST, CHGA, SYP
40non-small cell lung carcinoma29.9ENO2, UGT1A1, SYP, CHGA, NTS, TUSC2
41paraganglioma29.9MEN1, SST, SYP, GAST, CALCA, CHGA
42ovarian cancer29.8HTR3A
43pituitary adenoma29.8GHRH, SST, NTS, CHGA, SYP, MEN1
44dementia29.8HTR3A, SYP
45bipolar disorder29.8HTR3A
46hyperinsulinism29.8NPY, SST
47neuropathy29.8TAC1, CALCA
48glucose intolerance29.8PYY, GAST, MLN
49hepatocellular carcinoma29.8MEN1, UGT1A1, IFNA2
50somatostatinoma29.8CALCA, GHRH, CHGA, SST, GAST

Graphical network of the top 20 diseases related to Carcinoid Syndrome:



Diseases related to carcinoid syndrome

Clinical Features for Carcinoid Syndrome

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Drugs & Therapeutics for Carcinoid Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Carcinoid Syndrome

Drug clinical trials:

Search ClinicalTrials for Carcinoid Syndrome

Search NIH Clinical Center for Carcinoid Syndrome

Search CenterWatch for Carcinoid Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Carcinoid Syndrome

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Anatomical Context for Carcinoid Syndrome

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32MalaCards
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MalaCards organs/tissues related to Carcinoid Syndrome:

32
Lung, Heart, Small intestine, Colon, Appendix

Animal Models for Carcinoid Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Carcinoid Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0CALCA, HTR3A, NPY, CHGA, TAC1, TUSC2
2MP:00036318.1PYY, CALCA, HTR7, HTR3A, NPY, MEN1
3MP:00053787.9NPY, HTR3A, PYY, TUSC2, PPY, MEN1
4MP:00053867.9SMS, PYY, CALCA, HTR7, HTR3A, NPY
5MP:00053767.9HTR3A, HTR7, CALCA, PYY, TUSC2, NPY

Publications for Carcinoid Syndrome

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Genetic Variations for Carcinoid Syndrome

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Expression for genes affiliated with Carcinoid Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carcinoid Syndrome

Search GEO for disease gene expression data for Carcinoid Syndrome.

Pathways for genes affiliated with Carcinoid Syndrome

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Carcinoid Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5TAC1
2111in-pentetreotide4410.1CALCA, SST, CHGA, SYP
3streptozotocin4410.0IFNA2, SYP, CHGA, SST
4guanine44 11 2411.9UGT1A1, CALCA, NTS
5lafutidine449.8SST, MLN, GAST, CALCA
6mibg449.8SST, ENO2, CHGA, CALCA
7bethanechol44 28 1111.8NPY, SST, MLN, GAST
8omeprazole44 28 49 11 2413.7CHGA, SST, MLN, PYY, GAST
9sumatriptan44 28 59 49 11 2414.7HTR7, HTR3A, MLN, GHRH, CALCA
10i-app449.6GAST, PYY, TAC1, CALCA
115-hydroxyindoleacetic acid44 2410.6ENO2, HTR3A, CHGA, SST, GAST
12gnrh449.6HTR7, CHGA, PYY, GAST, GHRH, NTS
13amphetamine44 1110.5TAC1, SST, NTS, NPY, PYY
14forskolin44 49 1111.5CALCA, TAC1, NPY, ENO2, GHRH
15c-peptide449.4PYY, SST, NTS, GAST, CHGA
16yohimbine44 28 2 1112.4GAST, NPY, HTR3A, HTR7, NTS, PYY
17dexamethasone44 49 28 1112.4HTR3A, UGT1A1, GHRH, NTS, TAC1, ENO2
18oxyntomodulin44 5910.3SST, NTS, PYY, NPY, GAST, MLN
19glutamate449.3HTR7, TAC1, NTS, GHRH, GAST, NPY
20clonidine44 28 1111.2PYY, CALCA, GHRH, CHGA, NTS, SST
21carbachol44 28 1111.2NPY, GAST, CHGA, NTS, SST, PYY
22glucose449.1NPY, GHRH, GAST, MLN, NTS, IFNA2
23haloperidol44 28 2 49 1113.1HTR3A, PYY, TAC1, NTS, CHGA, SYP
24propranolol44 28 49 11 2413.1TAC1, GAST, SST, PYY, CALCA, HTR3A
25isoproterenol44 1110.0TAC1, NTS, SST, CHGA, NPY, CALCA
26indomethacin44 59 28 1112.0NPY, CALCA, UGT1A1, NTS, TAC1, ENO2
27nifedipine44 49 28 1112.0GHRH, NPY, GAST, MLN, TAC1, SST
28epinephrine44 11 2410.9CALCA, IFNA2, NPY, GAST, SST, TAC1
29ondansetron44 49 11 2411.9HTR3A, MLN, GAST, TAC1
30amine448.9ENO2, SYP, UGT1A1, GAST, HTR3A, HTR7
31atropine44 28 1110.9TAC1, PYY, CALCA, NPY, GAST, MLN
32nicotine44 49 28 1111.9NTS, GAST, UGT1A1, NPY, CHGA, TAC1
33thyroxine44 249.9GAST, IFNA2, MLN, CALCA, NTS, GHRH
34cyclic amp44 249.8SYP, TAC1, NPY, CHGA, CALCA, PYY
35tetrodotoxin44 59 2810.8TAC1, PYY, CALCA, MLN, NTS, NPY
36cisplatin44 49 59 1111.7ENO2, IFNA2, HTR3A, GAST, UGT1A1, SYP
37arginine448.7NPY, UGT1A1, MLN, SST, NTS, CHGA
38norepinephrine44 11 2410.6NTS, CHGA, SYP, GHRH, GAST, NPY
39gaba448.5CHGA, ENO2, TAC1, SST, NTS, SYP
40nitric oxide44 11 2410.4TAC1, CHGA, GHRH, NPY, CALCA, MLN
41octreotide44 59 28 1111.4PYY, CALCA, IFNA2, NPY, MLN, GAST
42testosterone44 59 11 2411.4CALCA, UGT1A1, GAST, GHRH, SYP, CHGA
43acth448.2PYY, CALCA, ENO2, IFNA2, NPY, GAST
44dopamine44 28 11 2411.2HTR7, CHGA, GHRH, MLN, GAST, NPY
45histamine44 28 2410.1SYP, MLN, GAST, NPY, HTR3A, IFNA2
46adenylate448.0HTR7, MLN, GHRH, CHGA, NPY, SST
47tyrosine447.9TAC1, NTS, CHGA, GAST, SYP, ENO2
485-hydroxytryptamine447.8HTR7, HTR3A, NPY, GAST, MLN, CALCA
49acetylcholine44 49 28 11 2411.8TAC1, ENO2, SST, NTS, CHGA, SYP
50calcium44 49 11 2410.7SYP, ENO2, TAC1, NTS, CHGA, NPY

GO Terms for genes affiliated with Carcinoid Syndrome

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16Gene Ontology
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Cellular components related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5TAC1, SST, HTR3A, CALCA
2extracellular spaceGO:0056158.6PYY, CALCA, IFNA2, NPY, GHRH, SST
3extracellular regionGO:0055767.6TAC1, PYY, CALCA, IFNA2, NPY, PPY

Biological processes related to Carcinoid Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.0HTR3A, HTR7
2feeding behaviorGO:0076319.9CALCA, NPY, PYY
3regulation of blood pressureGO:0082179.6CALCA, TAC1, CHGA, NPY
4neuropeptide signaling pathwayGO:0072189.5TAC1, NPY, CALCA
5G-protein coupled receptor signaling pathwayGO:0071869.5SST, MLN, GAST, PYY
6digestionGO:0075869.4SST, UGT1A1, PPY, NPY, HTR3A, PYY
7synaptic transmissionGO:0072689.3TAC1, SST, NPY, HTR3A, HTR7
8inflammatory responseGO:0069549.1IFNA2, CALCA, TUSC2, TAC1
9cell-cell signalingGO:0072678.8SST, GHRH, MLN, TAC1, CALCA, TUSC2

Molecular functions related to Carcinoid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6PYY, NPY, NTS
2receptor bindingGO:0051029.4MLN, PPY, NPY, CALCA
3hormone activityGO:0051798.9SST, MLN, GAST, PPY, CALCA, PYY

Products for genes affiliated with Carcinoid Syndrome

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  • Antibodies
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  • Antibodies

Sources for Carcinoid Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet