Cardia Cancer malady

MalaCards: Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to tongue cancer and brain cancer. An important gene associated with Cardia Cancer is PDHB (pyruvate dehydrogenase (lipoamide) beta), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Glutathione metabolism. The compounds methylchloride and 1-hydroxypyrene have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Descriptions:

cardia cancer 6 8 malignant neoplasm of cardia of stomach 6 malignant neoplasm of cardia 43

malignant neoplasms 43 ca cardia - stomach 6 cardiac carcinoma 43

Diseases related to cardia cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 652)

id	Related Disease	Score	Top Affiliating Genes
1	tongue cancer	32.7	CDKN2A, CD44, TP53
2	brain cancer	30.6	CD44, MDM2
3	oral cavity cancer	30.4	PARP1, GSTM1, GSTT1, TP53, CYP1A1, CYP2E1
4	liver cancer	29.3	PARP1, CDKN2A, GSTP1, TP53, CYP1A1, CYP2E1
5	nasopharynx carcinoma	29.2	PARP1, XRCC1, CDKN2A, GSTM1, GSTT1, MDM2
6	bronchogenic carcinoma	29.0	CDKN2A, MDM2, TP53
7	kidney cancer	29.0	GSTM1, GSTP1, GSTT1, TP53
8	malignant peripheral nerve sheath tumor	28.0	CDKN2A, CD44, MDM2
9	cervix carcinoma	27.8	CDKN2A, CD44, TP53
10	diffuse gastric cancer	27.7	GSTM1, GSTP1, GSTT1
11	orolaryngeal cancer	27.2	CDKN2A, GSTM1
12	pancreatic ductal carcinoma	27.2	CDKN2A, CD44, GSTP1, MDM2, TP53, TYMS
13	oropharyngeal cancer, adult	26.8	CDKN2A, TP53
14	skin cancer	26.5	MTHFR, XRCC1, CDKN2A, CD44, GSTM1, GSTP1
15	familial colorectal cancer	26.4	CDKN2A, GSTM1, TP53
16	esophageal cancer	26.4	PARP1, MTHFR, XRCC1, CDKN2A, GSTM1, GSTP1
17	testicular cancer	26.3	GSTM1, GSTP1, GSTT1, MDM2, TP53
18	angiosarcoma	26.1	CDKN2A, MDM2, TP53
19	non-hodgkin lymphoma	26.1	CD44, GSTM1, GSTT1, MDM2, CYP1A1, CYP2E1
20	verrucous carcinoma	25.9	CDKN2A, CD44, MDM2, TP53
21	laryngeal carcinoma	25.6	XRCC1, CDKN2A, CD44, GSTM1, GSTP1, GSTT1
22	urinary bladder cancer	25.5	CDKN2A, GSTM1, GSTT1, MDM2, TP53
23	ductal carcinoma in situ	25.4	CDKN2A, CD44, GSTP1, MDM2, TP53
24	prostate cancer, progression of	25.4	CDKN2A, CD44, GSTP1, MDM2, TP53
25	thyroid cancer	24.8	CDKN2A, CD44, GSTM1, GSTP1, GSTT1, MDM2
26	esophagitis	24.6	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
27	myocardial infarction	24.6	PARP1, MTHFR, XRCC1, CDKN2A, GSTM1, GSTP1
28	pancreatic carcinoma	24.5	CDKN2A, CD44, MDM2, TP53, TYMS, GAST
29	stomach carcinoma	24.1	MTRR, MTHFR, XRCC1, CD44, GSTM1, GSTP1
30	esophageal carcinoma	24.0	CDKN2A, CD44, GSTM1, GSTP1, GSTT1, MDM2
31	acute lymphoblastic leukemia	23.9	MTHFR, XRCC1, CDKN2A, GSTM1, GSTP1, GSTT1
32	retinoblastoma	23.9	PARP1, MTHFR, CDKN2A, MDM2, TP53, TYMS
33	pancreatic cancer	23.7	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
34	carcinoma	23.6	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
35	lung carcinoma	23.4	PARP1, XRCC1, CDKN2A, CD44, GSTM1, GSTP1
36	breast cancer	23.3	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
37	atherosclerosis	23.2	MTRR, MTHFR, CDKN2A, CD44, GSTM1, GSTP1
38	ovarian cancer	23.2	PARP1, MTHFR, XRCC1, CDKN2A, CD44, GSTM1
39	osteosarcoma	23.0	PARP1, MTHFR, CDKN2A, CD44, GSTP1, MDM2
40	malignant mesothelioma	22.9	PARP1, XRCC1, CDKN2A, GSTM1, GSTT1, MDM2
41	gallbladder carcinoma	22.7	MTHFR, XRCC1, CDKN2A, CD44, GSTM1, GSTP1
42	leukemia	22.6	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
43	glioblastoma	22.1	PARP1, MTHFR, CDKN2A, CD44, GSTP1, MDM2
44	lymphoblastic leukemia	21.9	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
45	prostate carcinoma	21.9	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
46	thyroid carcinoma	21.9	PARP1, MTHFR, XRCC1, CDKN2A, CD44, GSTM1
47	cervical carcinoma	21.5	PARP1, MTRR, MTHFR, XRCC1, CDKN2A, CD44
48	hodgkin's lymphoma	20.9	PARP1, MTRR, MTHFR, CDKN2A, CD44, GSTM1
49	cervical cancer	20.9	PARP1, MTHFR, XRCC1, CDKN2A, CD44, GSTM1
50	gastric cancer	20.5	PARP1, MTHFR, XRCC1, CDKN2A, CD44, GSTM1

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to cardia cancer:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.2	CYP2E1, TP53
2	no phenotypic analysis	MP:0003012	7.9	PARP1, MTHFR, CD44, TP53, CYP1A1
3	mortality/aging	MP:0010768	7.6	GAST, CYP2E1, TP53, XRCC1, MTHFR, PARP1
4	tumorigenesis	MP:0002006	7.1	XRCC1, GAST, CYP2E1, TP53, MDM2, GSTP1
5	growth/size phenotype	MP:0005378	7.1	TP53, MDM2, GSTP1, CD44, XRCC1, MTHFR
6	integument phenotype	MP:0010771	7.0	TP53, MDM2, GSTP1, CD44, CDKN2A, MTHFR
7	homeostasis/metabolism phenotype	MP:0005376	5.9	GAST, CYP2E1, CYP1A1, TP53, GSTT1, GSTM1

Articles related to cardia cancer:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers. (21155014)	Ding G.C.... Wang L.D.	2010	CDKN2A
2	Genetic polymorphisms of glutathione S-transferase ge nes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers. (19618282)	Zendehdel K.... Ye W.	2009	GSTP1, GSTT1, GSTM1
3	Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. (17638920)	Yang M.... Lin D.	2007	MDM2, TP53
4	Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. (17317788)	Hansen S.... McColl K.E.	2007	GAST
5	Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. (16890595)	Miao X.... Lin D.	2006	PARP1, XRCC1
6	Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population. (16045580)	Wang L.D.... Li J.L.	2005	TYMS, MTHFR
7	Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer. (15793883)	Cai L.... Zhang Z.F.	2005	CYP2E1
8	Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes. (15801491)	Roth M.J.... Qiao Y.L.	2004	GSTP1, CYP1A1, GSTT1
9	Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer. (15533591)	Ratnasinghe L.D.... Taylor P.R.	2004	XRCC1
10	Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China. (14652285)	Stolzenberg-Solomon R.Z.... Mark S.D.	2003	MTHFR, MTRR
11	A favorable impact of preoperative FPLC chemotherapy on patients with gastric cardia cancer. (10671664)	Wang X.L.... Sun X.F.	2000	CD44

Genes related to cardia cancer according to GeneCards:

(show all 17)

id	Symbol	Description	Score	GeneCards Section Context
1	PDHB	pyruvate dehydrogenase (lipoamide) beta	11.0
2	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	11.0	Publications
3	DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	11.0
4	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
5	GSTP1	glutathione S-transferase pi 1	11.0	Publications
6	GSTT1	glutathione S-transferase theta 1	11.0	Publications
7	GSTM1	glutathione S-transferase mu 1	11.0	Publications
8	GAST	gastrin	11.0	Publications
9	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
10	PARP1	poly (ADP-ribose) polymerase 1	11.0	Publications
11	TYMS	thymidylate synthetase	11.0	Publications
12	CD44	CD44 molecule (Indian blood group)	11.0	Publications
13	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
14	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
15	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
16	TP53	tumor protein p53	11.0	Publications
17	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications

Pathways related to cardia cancer according to GeneDecks:

(show all 28)

id	Pathway	Score	Top Affiliating Genes
1	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	10.0	GSTT1, GSTP1, GSTM1
2	Glutathione metabolism10	10.0	GSTT1, GSTP1, GSTM1
3	Glutathione metabolism20	9.9	GSTT1, GSTP1, GSTM1
4	Acetaminophen metabolism41	9.8	CYP2E1, CYP1A1, GSTP1
5	Acetaminophen metabolism10	9.8	CYP2E1, CYP1A1, GSTP1
6	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	9.7	TYMS, MTHFR, MTRR
7	Drug metabolism - cytochrome P45020	9.7	CYP2E1, GSTT1, GSTP1, GSTM1
8	Benzo[a]pyrene metabolism41	9.7	CYP1A1, GSTP1
9	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	9.7	MTRR, MTHFR, TYMS
10	Benzo[a]pyrene metabolism10	9.5	CYP1A1, GSTP1
11	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	9.4	TYMS, GSTM1, MTHFR, MTRR
12	Transcription P53 signaling pathway10	9.3	CDKN2A, TP53
13	Naphthalene metabolism10	9.3	GSTM1, CYP2E1, CYP1A1, GSTT1, GSTP1
14	Naphthalene metabolism41	9.3	CYP2E1, CYP1A1, GSTT1, GSTP1, GSTM1
15	Metabolism of xenobiotics by cytochrome P45020	9.3	CYP2E1, CYP1A1, GSTT1, GSTP1, GSTM1
16	Fluoropyrimidine Pathway, Pharmacodynamics34	9.1	MTHFR, TP53, TYMS
17	Glioblastoma Multiforme36	9.0	MDM2, TP53
18	Inhibition of Ribosome Biogenesis by p14(ARF)36	8.8	TP53, MDM2, CDKN2A
19	Prostate cancer20	8.8	GSTP1, MDM2, TP53
20	Bladder cancer20	8.8	CDKN2A, MDM2, TP53
21	HIF1Alpha Pathway36	8.7	CDKN2A, MDM2, TP53
22	DNA Damage3	8.7	XRCC1, MDM2, TP53, TYMS
23	Transcription_P53 signaling pathway41	8.7	TP53, MDM2, CDKN2A
24	Glioma20	8.7	CDKN2A, MDM2, TP53
25	p53 signaling pathway20	8.7	TP53, MDM2, CDKN2A
26	Melanoma20	8.6	CDKN2A, MDM2, TP53
27	Chronic myeloid leukemia20	8.6	TP53, MDM2, CDKN2A
28	Cell Cycle / Checkpoint Control3	8.0	TYMS, TP53, MDM2, GSTP1, CDKN2A, XRCC1

Compounds related to cardia cancer according to GeneDecks:

(show top 50)    (show all 183)

id	Compound	Score	Top Affiliating Genes
1	methylchloride32	9.8	GSTT1, GSTM1, GSTP1
2	1-hydroxypyrene32	9.8	GSTM1, GSTP1, GSTT1, CYP2E1
3	s-phenylmercapturic acid32	9.8	CYP2E1, GSTT1, GSTM1, GSTP1
4	vinylchloride32	9.7	GSTM1, XRCC1, GSTT1, CYP2E1
5	1,3-butadiene32	9.7	CYP2E1, GSTT1, GSTM1, GSTP1
6	estrogen32	9.7	MTHFR, GAST, GSTP1
7	styrene32	9.6	GSTP1, GSTT1, CYP2E1, GSTM1
8	trichloroethylene32	9.6	GSTP1, GSTT1, CYP2E1, GSTM1
9	p00332	9.6	MTRR, MDM2, CD44
10	hydrochloric acid32 18	10.5	GAST, GSTT1, GSTP1, GSTM1
11	trans,trans-muconic acid32	9.5	GSTT1, CYP2E1, GSTM1
12	dichloromethane32	9.5	GSTP1, TYMS, CYP2E1, GSTT1
13	benzene32	9.4	XRCC1, CYP2E1, GSTM1, GSTT1
14	acetone32	9.3	GSTM1, CYP2E1, CYP1A1, GSTT1, GSTP1
15	mspi32	9.3	XRCC1, GSTM1, GSTT1, CYP1A1, CYP2E1
16	epoxide32	9.1	GSTT1, CYP1A1, CYP2E1, GSTP1, GSTM1, XRCC1
17	ifosfamide32 9 9	11.0	GSTM1, TYMS, GSTP1, GSTT1, MDM2
18	chi 232	9.0	GSTM1, GSTT1, MDM2, MTHFR
19	arginine32	8.9	CYP1A1, MDM2, GSTT1, XRCC1, CD44
20	betacarotene32	8.9	MTHFR, CYP2E1, CYP1A1, GSTM1, XRCC1
21	chlorambucil32 9 9	10.6	MDM2, GSTP1, TP53, GSTM1
22	bcnu32	8.6	GSTT1, GSTP1, CDKN2A, PARP1, TP53
23	gsts32	8.6	MTHFR, GSTT1, GSTM1, CYP1A1, CYP2E1, GSTP1
24	temozolomide32 9 9	10.5	XRCC1, TP53, CDKN2A, PARP1
25	p00232	8.4	MTHFR, XRCC1, CD44, GSTM1, GSTT1, MDM2
26	aflatoxin b132 18	9.4	TP53, MDM2, GSTM1, CDKN2A, GSTT1
27	ascorbic acid32 18	9.2	CYP1A1, GSTT1, CYP2E1, GAST, XRCC1, GSTP1
28	bpde32	8.2	GSTM1, CYP1A1, TP53, MDM2, GSTT1, GSTP1
29	doxorubicin32 34 9 9	11.2	GSTT1, GSTP1, MDM2, PARP1, TP53, CD44
30	bleomycin32 9 9	10.2	GSTM1, XRCC1, TP53, CD44, GSTP1
31	methotrexate32 34 42 9 9	12.0	CDKN2A, GSTM1, MTHFR, MTRR, GSTP1, MDM2
32	benzo(a)pyrene32	8.0	GSTT1, MDM2, GSTM1, TP53, GSTP1, XRCC1
33	folate32	7.9	CDKN2A, TYMS, GSTT1, GSTP1, GSTM1, GAST
34	resveratrol32 9 18 9	10.9	GAST, CYP2E1, CYP1A1, MDM2, TP53, PARP1
35	docetaxel32 34 9 9	10.9	TYMS, TP53, MDM2, GSTP1, CDKN2A, PARP1
36	etoposide32 42 9 9	10.9	TP53, CYP2E1, MDM2, GSTP1, XRCC1, PARP1
37	carboplatin32 34 9 9	10.8	TYMS, TP53, PARP1, MTHFR, CD44, MDM2
38	adriamycin32	7.8	CDKN2A, MDM2, TP53, TYMS, GSTP1, CD44
39	camptothecin32 42 9 9	10.7	XRCC1, CDKN2A, GSTP1, TP53, TYMS, MDM2
40	valine32	7.6	MDM2, CDKN2A, GSTT1, MTHFR, GSTM1, GSTP1
41	creatinine32	7.4	CD44, CDKN2A, XRCC1, MTHFR, GSTM1, GSTP1
42	oxaliplatin32 34 9 9	10.4	CYP2E1, MTHFR, XRCC1, TYMS, GSTM1, GSTP1
43	5fluorouracil32	7.3	GSTM1, MDM2, TYMS, MTHFR, CDKN2A, XRCC1
44	irinotecan32 34 9 9	10.2	PARP1, XRCC1, CDKN2A, GSTP1, MDM2, TP53
45	testosterone32 9 18 9	10.1	GAST, MTHFR, CD44, GSTM1, CYP2E1, CYP1A1
46	actinomycin d32	7.1	GSTP1, CDKN2A, CYP1A1, MDM2, CD44, PARP1
47	paclitaxel32 34 9 9	10.1	CYP1A1, TP53, MDM2, GSTP1, PARP1, CDKN2A
48	thymidylate32	7.1	CDKN2A, GSTM1, MTRR, MTHFR, XRCC1, MDM2
49	vegf32	6.6	CD44, PARP1, GAST, TYMS, CYP1A1, TP53
50	cisplatin32 34 9 9	9.1	TYMS, PARP1, MTHFR, GAST, XRCC1, CDKN2A

Cellular components related to cardia cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear body	GO:016604	8.2	TP53, MDM2, CDKN2A
2	nucleoplasm	GO:005654	7.5	PARP1, XRCC1, CDKN2A, MDM2, TP53, TYMS
3	cytosol	GO:005829	6.3	MTRR, TYMS, DYNC1I2, TP53, MDM2, GSTT1

Biological processes related to cardia cancer according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	methionine biosynthetic process	GO:009086	9.8	MTRR, MTHFR
2	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:043518	9.3	MDM2, CD44
3	xenobiotic metabolic process	GO:006805	9.3	CYP2E1, CYP1A1, GSTP1, GSTM1
4	base-excision repair	GO:006284	9.2	PARP1, XRCC1, TP53
5	replicative senescence	GO:090399	9.1	TP53, CDKN2A
6	rRNA transcription	GO:009303	9.1	CDKN2A, TP53
7	negative regulation of apoptotic process	GO:043066	8.1	CD44, GSTP1, MDM2, TP53
8	small molecule metabolic process	GO:044281	7.8	MTHFR, TYMS, PDHB, CYP2E1, CYP1A1, GSTP1

Molecular functions related to cardia cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutathione transferase activity	GO:004364	9.7	GSTM1, GSTP1, GSTT1