MCID: CRD005
MIFTS: 53

Cardia Cancer malady

Cancer diseases, Gastrointestinal diseases categories

Summaries for Cardia Cancer

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32MalaCards
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MalaCards: Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to esophagitis and esophageal cancer. An important gene associated with Cardia Cancer is XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The compounds vincristine and egcg have been mentioned in the context of this disorder. Affiliated tissues include t cells, spleen and heart, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Cardia Cancer

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cardia cancer 8
malignant neoplasm of cardia of stomach 8
malignant neoplasm of cardia 60
ca cardia - stomach 8
cardiac carcinoma 60


External Ids:

Disease Ontology8 DOID:10548
ICD9CM27 151.0
ICD1025 C16.0

Related Diseases for Cardia Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cardia Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.0GAST
2esophageal cancer31.0MDM2, CDKN2A, CYP1A1, TP53, GSTP1
3gastric adenocarcinoma30.2GSTT1, GSTM1, CD44, TYMS, GAST
4adenocarcinoma30.2CDKN2A, TYMS, MDM2, GAST, XRCC1, CD44
5gastritis30.0TP53, GAST
6stomach cancer30.0GAST, TYMS, CDKN2A, CD44, TP53, GSTP1
7gastric cardia adenocarcinoma10.2
8esophageal disease10.0
9heart cancer10.0
10lipoma10.0
11lymph node cancer10.0
12spleen cancer10.0
13meningioma10.0GSTT1
14liver cirrhosis10.0CYP2E1
15hepatitis b10.0GSTT1
16galactosemia10.0CYP2E1
17glaucoma10.0GSTP1
18primary open angle glaucoma10.0GSTM1
19malignant pleural mesothelioma10.0TYMS
20motor neuron disease10.0GSTT1
21duodenitis10.0GAST
22fatty liver disease10.0CYP2E1
23hepatoblastoma10.0CYP2E1
24biliary tract neoplasm10.0TYMS
25multiple sclerosis10.0GSTM1
26cataract10.0GSTT1
27chondrosarcoma10.0MDM2
28schistosomiasis10.0GSTM1
29eclampsia10.0MTHFR
30hypertension10.0MTHFR
31fibrosarcoma10.0MDM2
32myeloid leukemia10.0PARP1
33ependymoma10.0MDM2
34schizophrenia10.0MTHFR
35gastroesophageal reflux disease10.0GAST
36pancreatitis10.0GSTP1, CYP2E1
37arthritis10.0CD44
38pancreas disease10.0GAST
39myelodysplastic syndromes10.0GSTT1, GSTM1
40gastroduodenitis10.0GAST
41cerebrovascular disease10.0MTHFR
42neutropenia10.0TYMS
43atopy10.0GSTP1, GSTT1
44lichen sclerosus10.0CD44
45stroke, ischemic10.0MTHFR
46infertility10.0CYP1A1, GSTT1
47deficiency anemia10.0TYMS, GSTM1
48asbestosis10.0GSTM1, GSTT1
49down syndrome10.0MTHFR, MTRR
50primary hyperoxaluria10.0CD44

Graphical network of the top 20 diseases related to Cardia Cancer:



Diseases related to cardia cancer

Clinical Features for Cardia Cancer

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Drugs & Therapeutics for Cardia Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cardia Cancer

Drug clinical trials:

Search ClinicalTrials for Cardia Cancer

Search NIH Clinical Center for Cardia Cancer

Search CenterWatch for Cardia Cancer

Genetic Tests for Cardia Cancer

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Anatomical Context for Cardia Cancer

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32MalaCards
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MalaCards organs/tissues related to Cardia Cancer:

32
T cells, Spleen, Heart, Lymph node

Animal Models for Cardia Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cardia Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CYP2E1, CDKN2A, MDM2, GAST
2MP:00053769.0XRCC1, GAST, MTRR, MTHFR, GSTT1
3MP:00030128.5MDM2, CDKN2A, CD44, CYP1A1, TP53
4MP:00107718.3MDM2, CDKN2A, PARP1, TP53, GSTP1
5MP:00053708.2TP53, CYP2E1, CYP1A1, CD44, CDKN2A, MDM2
6MP:00053787.1XRCC1, MDM2, MTRR, MTHFR, CDKN2A, CD44
7MP:00107685.8MDM2, GAST, XRCC1, DYNC1I2, MTHFR, CDKN2A

Publications for Cardia Cancer

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Sources:
50PubMed
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Articles related to Cardia Cancer:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Despite shared susceptibility loci, esophageal squamous cell carcinoma embraces more familial cancer than gastric cardia adenocarcinoma in the Taihang Mountains high-risk region of northern central China. (23286478)
2013
2
A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou. (23803050)
2013
3
Patrilineal background of esophageal cancer and gastric cardia cancer patients in a chaoshan high-risk area in china. (24339953)
2013
4
Nuclear Nano-architecture Markers of Gastric Cardia and Upper Squamous Esophagus Detect Esophageal Cancer "Field Effect". (24155774)
2013
5
Diverging trends in the incidence of reflux-related and Helicobacter pylori-related gastric cardia cancer. (22914345)
2013
6
Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer. (22580669)
2012
7
Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. (22317953)
2012
8
Is cardia cancer aetiologically different from distal stomach cancer? (21150780)
2011
9
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (22037551)
2011
10
The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer. (21792941)
2011
11
Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. (21184266)
2011
12
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. (20699381)
2010
13
En bloc resection of cardia cancer and lipoma with endoscopic submucosal dissection. (18657491)
2009
14
An orthotopic nude mouse model for preclinical research of gastric cardia cancer. (18825389)
2009
15
Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. (17965056)
2008
16
New design esophageal stents for the palliation of dysphagia from esophageal or gastric cardia cancer: a randomized trial. (17900325)
2008
17
Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. (18287862)
2008
18
Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction. (19120911)
2008
19
Patient demographics and lifestyle factors influencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden. (18434132)
2008
20
Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes. (17444864)
2007
21
Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer. (17383456)
2007
22
Ultrasound, computed tomography, or the combination for the detection of supraclavicular lymph nodes in patients with esophageal or gastric cardia cancer: a comparative study. (17455243)
2007
23
Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. (17638920)
2007
24
Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia. (17578895)
2007
25
Spleen preservation in radical surgery for gastric cardia cancer. (17265118)
2007
26
Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. (16890595)
2006
27
DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to cardia and non-cardia gastric cancer: a case-control study]. (16981340)
2006
28
Adjuvant therapy in gastric and cardia cancer: should we irradiate? (16721135)
2006
29
Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population. (16045580)
2005
30
Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer. (15793883)
2005
31
Influence of surgery-related factors on quality of life after esophageal or cardia cancer resection. (15951920)
2005
32
Cytokeratin phenotyping does not help in distinguishing oesophageal adenocarcinoma from cancer of the gastric cardia. (15976339)
2005
33
E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population. (15609397)
2005
34
Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. (14684401)
2004
35
Accuracy of linear-array EUS for preoperative staging of gastric cardia cancer. (15229425)
2004
36
Sentinel node detection in Barrett's and cardia cancer. (15023763)
2004
37
No changing trends in incidence of gastric cardia cancer in Korea. (12589087)
2003
38
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China. (14652285)
2003
39
Endoscopic mucosal resection for early cardia cancer by minimum laparotomy. (12620572)
2003
40
Inverse association between intake of cereal fiber and risk of gastric cardia cancer. (11665692)
2001
41
Involvement of cancer-activating genes on chromosomes 7 and 8 in esophageal (Barrett's) and gastric cardia adenocarcinoma. (11911252)
2001
42
Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. (10365894)
1999
43
Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (9973227)
1999
44
RESPONSE: re: evaluating gastric cancer misclassification: a potential explanation for the rise in cardia cancer incidence (10491440)
1999
45
Quantitative fluorescence image analysis of DNA content and nuclear morphology on esophageal balloon cytology smears and subsequent development of esophageal and gastric cardia cancer in Linxian, China. (9456244)
1998
46
Interobserver agreement in endoscopic ultrasonography staging of esophageal and cardia cancer. (8903812)
1996
47
Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. (7742727)
1995
48
Esophageal balloon cytology and subsequent risk of esophageal and gastric-cardia cancer in a high-risk Chinese population. (8206671)
1994
49
Diagnostic factors in gastric cardia cancer invading the esophagus. (8422621)
1993
50
Invisible cardia cancer metastasis to the diaphragm. (1405435)
1992

Genetic Variations for Cardia Cancer

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Expression for genes affiliated with Cardia Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardia Cancer

Search GEO for disease gene expression data for Cardia Cancer.

Pathways for genes affiliated with Cardia Cancer

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Cardia Cancer according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GSTP1, GSTT1
210.0GSTT1, GSTM1
39.7GSTM1, GSTT1, GSTP1
4
Glutathione metabolism
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9.7GSTM1, GSTT1, GSTP1
5
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9.7CDKN2A, MDM2
6
Hide members
9.7GSTP1, TP53
7
Hide members
9.7GSTP1, CYP2E1, CYP1A1
8
Acetaminophen metabolism
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9.7CYP1A1, CYP2E1, GSTP1
9
Hide members
9.7MDM2, TP53
10
Hide members
9.7DYNC1I2
11
Hide members
9.6TYMS, MTHFR, MTRR
12
Hide members
9.6MTRR, MTHFR, TYMS
13
Hide members
9.6MDM2, CYP1A1, CYP2E1
14
Hide members
9.4XRCC1, PARP1, PARP4
159.3TP53, TYMS, MTHFR
16
Hide members
9.3TP53, TYMS, MTHFR
17
Hide members
9.2XRCC1, MDM2, TYMS, CDKN2A
18
Transcription P53 signaling pathway
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9.2TP53, CDKN2A, MDM2
19
Hide members
9.2MDM2, CDKN2A, TP53
209.2TP53, CDKN2A, MDM2
219.2MDM2, CDKN2A, TP53
229.2MDM2, CDKN2A, TP53
239.2TP53, CDKN2A, MDM2
24
Naphthalene metabolism
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9.2GSTP1, GSTT1, GSTM1, CYP2E1, CYP1A1
25
Hide members
9.2CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
26
Hide members
9.0MTRR, CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
278.9GSTP1, TP53, CDKN2A, MDM2
28
Hide members
8.8TP53, CD44, CDKN2A, MDM2
298.8MDM2, CDKN2A, CD44, TP53
308.8MDM2, CDKN2A, CD44, TP53
31
Hide members
8.4PDHB, MTRR, MTHFR, TYMS, CD44, CYP1A1

Compounds for genes affiliated with Cardia Cancer

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Cardia Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.5GSTM1
2egcg4410.4CYP2E1
3resveratrol44 59 11 2413.1GAST
4bpde4410.0GSTP1, MDM2, CYP1A1
5s-phenylmercapturic acid449.9GSTM1, CYP2E1, GSTT1, GSTP1
6vinylchloride449.9GSTM1, XRCC1, CYP2E1, GSTT1
71,3-butadiene449.8GSTM1, GSTT1, GSTP1, CYP2E1
81-hydroxypyrene449.8CYP2E1, CYP1A1, GSTM1, GSTT1
9methylchloride449.7GSTT1, GSTP1, GSTM1
10styrene449.7CYP2E1, GSTT1, GSTP1, GSTM1
11trichloroethylene449.6GSTM1, GSTP1, CYP2E1, GSTT1
12dichloromethane449.6TYMS, CYP2E1, GSTP1, GSTT1
13acetone449.5GSTP1, GSTT1, CYP2E1, CYP1A1, GSTM1
14mspi449.5XRCC1, CYP1A1, GSTT1, CYP2E1, GSTM1
15ifosfamide44 1110.5TYMS, MDM2, GSTT1, GSTP1, GSTM1
16h2o2449.4PARP1, CYP1A1, CDKN2A, CYP2E1
17chi 2449.4GSTT1, GSTM1, MTHFR, MDM2
18epoxide449.4GSTP1, GSTT1, GSTM1, CYP2E1, XRCC1, CYP1A1
19isoniazid49 44 1111.3CDKN2A, CD44, CYP2E1, GSTM1, GSTT1
20fluorouracil49 1110.2GSTP1, XRCC1, MTHFR, TYMS, TP53
21etoposide44 49 59 1112.2CD44, GSTP1, XRCC1, MDM2, TYMS, CYP2E1
22p003449.2XRCC1, MDM2, CD44, GSTM1, GSTT1, MTRR
23betacarotene449.1GSTM1, CYP2E1, XRCC1, MTHFR, CYP1A1
24aflatoxin b144 2410.1TP53, MDM2, GSTM1, CDKN2A, GSTT1
25gsts449.1GSTM1, CYP1A1, CYP2E1, XRCC1, GSTT1, GSTP1
26hydrochloric acid44 2410.0GSTP1, GSTT1, GAST, GSTM1
27bcnu449.0TP53, GSTT1, GSTP1, CDKN2A, PARP1
28p002449.0XRCC1, GSTT1, CD44, MTHFR, MDM2, GSTM1
29benzo(a)pyrene448.8GSTP1, GSTT1, GSTM1, CYP1A1, MDM2, XRCC1
30methotrexate44 49 1110.7GSTP1, TYMS, MDM2, GSTM1, MTHFR, MTRR
31ascorbic acid44 249.7GSTT1, GSTM1, CYP2E1, CYP1A1, MTHFR, XRCC1
32creatinine448.6XRCC1, GAST, TYMS, CDKN2A, CYP2E1, GSTM1
33docetaxel44 49 59 1111.5CDKN2A, TYMS, PARP1, TP53, MDM2, GSTP1
34adriamycin448.5GSTP1, CD44, TYMS, MDM2, CDKN2A, TP53
35camptothecin44 59 1110.5CDKN2A, TYMS, MDM2, XRCC1, PARP1, TP53
36valine448.4CYP1A1, CDKN2A, TYMS, MTHFR, MDM2, GSTM1
37oxaliplatin44 49 1110.3CYP1A1, TYMS, MTHFR, XRCC1, CYP2E1, TP53
38paclitaxel44 49 1110.3MDM2, TYMS, GSTP1, CD44, TP53, PARP1
395fluorouracil448.3GSTM1, TP53, CDKN2A, TYMS, XRCC1, MDM2
40irinotecan44 49 1110.2GSTP1, XRCC1, MDM2, MTHFR, TYMS, CDKN2A
41thymidylate448.1TP53, CDKN2A, TYMS, MTHFR, MTRR, MDM2
42folate448.0GSTP1, GSTT1, GSTM1, XRCC1, GAST, MTRR
43cyclophosphamide44 49 119.8MTHFR, XRCC1, MDM2, GSTM1, TP53, CYP2E1
44doxorubicin44 49 119.8GSTP1, GSTM1, TP53, PARP1, CD44, CDKN2A
45carboplatin44 49 119.7GSTP1, GSTT1, GSTM1, XRCC1, MDM2, MTHFR
46arginine447.6CDKN2A, TP53, CYP1A1, XRCC1, GSTT1, MDM2
47testosterone44 59 11 2410.6GSTM1, GAST, CYP1A1, MDM2, MTHFR, CYP2E1
48actinomycin d447.5TP53, PARP1, GSTP1, CYP1A1, CDKN2A, MDM2
49vegf447.1GSTP1, CDKN2A, PARP1, GAST, MDM2, TYMS
50cisplatin44 49 59 119.3GSTP1, MDM2, GSTT1, GSTM1, TP53, PARP1

GO Terms for genes affiliated with Cardia Cancer

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16Gene Ontology
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Cellular components related to Cardia Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.1MDM2, CDKN2A, TP53
2mitochondrionGO:0057398.4GSTP1, TP53, CYP2E1, CYP1A1, CDKN2A, TYMS
3nucleoplasmGO:0056548.0XRCC1, MDM2, TYMS, CDKN2A, PARP1, TP53
4cytosolGO:0058296.8GSTP1, DYNC1I2, MDM2, MTRR, MTHFR, TYMS

Biological processes related to Cardia Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1methionine biosynthetic processGO:00908610.0MTRR, MTHFR
2glutathione derivative biosynthetic processGO:19016879.9GSTM1, GSTT1, GSTP1
3response to vitamin AGO:0331899.9CYP1A1, TYMS
4glutathione metabolic processGO:0067499.8GSTP1, GSTT1, GSTM1
5base-excision repairGO:0062849.5XRCC1, PARP1, TP53
6response to antibioticGO:0466779.5TP53, CYP1A1, MDM2
7negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435189.5MDM2, CD44
8replicative senescenceGO:0903999.4CDKN2A, TP53
9xenobiotic metabolic processGO:0068059.2MTRR, CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
10DNA repairGO:0062819.1PARP4, PARP1, TYMS, XRCC1
11response to drugGO:0424938.6GSTT1, XRCC1, MDM2, TYMS, CYP1A1, CYP2E1
12small molecule metabolic processGO:0442817.9PDHB, MTRR, MTHFR, TYMS, CD44, CYP1A1

Molecular functions related to Cardia Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, andGO:01670910.0CYP2E1, MTRR
2glutathione transferase activityGO:0043649.7GSTM1, GSTT1, GSTP1
3MDM2/MDM4 family protein bindingGO:0973719.2TP53, CDKN2A
4p53 bindingGO:0020399.1TP53, CDKN2A, MDM2
5enzyme bindingGO:0198998.4GSTM1, TP53, PARP4, CYP2E1, CYP1A1, MDM2

Products for genes affiliated with Cardia Cancer

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  • Antibodies
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Sources for Cardia Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet