MCID: CRD005
MIFTS: 48

Cardia Cancer malady

Cancer, Gastrointestinal categories

Summaries for Cardia Cancer

Sources:
33MalaCards
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MalaCards: Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to adenocarcinoma and stomach cancer. An important gene associated with Cardia Cancer is XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The compounds vincristine and egcg have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and brain, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Cardia Cancer

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Aliases & Descriptions:

cardia cancer 8
malignant neoplasm of cardia of stomach 8
malignant neoplasm of cardia 61
ca cardia - stomach 8
cardiac carcinoma 61


External Ids:

Disease Ontology8 DOID:10548
ICD9CM27 151.0
ICD1025 C16.0

Related Diseases for Cardia Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cardia Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2CDKN2A, TYMS, MDM2, GAST, XRCC1, CD44
2stomach cancer30.0GAST, TYMS, CDKN2A, CD44, TP53, GSTP1
3gastric cardia adenocarcinoma10.2
4dysphagia10.2
5h. pylori infection10.2
6spleen cancer10.1
7meningioma10.0GSTT1
8liver cirrhosis10.0CYP2E1
9esophagitis10.0GAST
10hepatitis b10.0GSTT1
11galactosemia10.0CYP2E1
12glaucoma10.0GSTP1
13primary open angle glaucoma10.0GSTM1
14malignant pleural mesothelioma10.0TYMS
15motor neuron disease10.0GSTT1
16duodenitis10.0GAST
17fatty liver disease10.0CYP2E1
18hepatoblastoma10.0CYP2E1
19biliary tract cancer10.0TYMS
20multiple sclerosis10.0GSTM1
21cataract10.0GSTT1
22chondrosarcoma10.0MDM2
23schistosomiasis10.0GSTM1
24eclampsia10.0MTHFR
25hypertension10.0MTHFR
26fibrosarcoma10.0MDM2
27myeloid leukemia10.0PARP1
28ependymoma10.0MDM2
29schizophrenia10.0MTHFR
30gastroesophageal reflux disease10.0GAST
31pancreatitis10.0GSTP1, CYP2E1
32arthritis10.0CD44
33pancreas disease10.0GAST
34myelodysplastic syndromes10.0GSTT1, GSTM1
35gastroduodenitis10.0GAST
36cerebrovascular disease10.0MTHFR
37neutropenia10.0TYMS
38atopy10.0GSTP1, GSTT1
39lichen sclerosus10.0CD44
40stroke, ischemic10.0MTHFR
41infertility10.0CYP1A1, GSTT1
42deficiency anemia10.0TYMS, GSTM1
43asbestosis10.0GSTM1, GSTT1
44down syndrome10.0MTHFR, MTRR
45primary hyperoxaluria10.0CD44
46thrombophilia10.0MTHFR
47coronary heart disease10.0GSTT1, MTHFR
48giant cell glioblastoma10.0MDM2
49myocardial infarction10.0MTHFR, GSTT1
50obesity10.0GSTM1, CYP2E1, XRCC1

Graphical network of the top 20 diseases related to Cardia Cancer:



Diseases related to cardia cancer

Clinical Features for Cardia Cancer

Drugs & Therapeutics for Cardia Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cardia Cancer

Drug clinical trials:

Search ClinicalTrials for Cardia Cancer

Search NIH Clinical Center for Cardia Cancer

Search CenterWatch for Cardia Cancer

Genetic Tests for Cardia Cancer

Anatomical Context for Cardia Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cardia Cancer:

33
Skin, Tongue, Brain, Kidney, Lymph node, Lung, Spleen, Heart, Small intestine, Breast, Prostate, T cells, B cells

Animal Models for Cardia Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cardia Cancer

Sources:
51PubMed
See all sources

Articles related to Cardia Cancer:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
De novo treatment of diffuse large B-cell lymphoma with rituximab, cyclophosphamide, vincristine, gemcitabine, and prednisolone in patients with cardiac comorbidity: a United kingdom national cancer research institute trial. (24220559)
2014
2
Comparison of cancer risk associated with low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction in women versus men. (23972348)
2013
3
Despite shared susceptibility loci, esophageal squamous cell carcinoma embraces more familial cancer than gastric cardia adenocarcinoma in the Taihang Mountains high-risk region of northern central China. (23286478)
2013
4
A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou. (23803050)
2013
5
Gene expression profiling for cardiac rejection surveillance is not predictive of post-transplantation skin cancer. (24090261)
2013
6
Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer. (23825906)
2013
7
Clinical outcomes and cardiac safety of continuous antiHer2 therapy in c-erbB2-positive metastatic breast cancer patients. (24392943)
2013
8
Consideration of cardia preserving proximal gastrectomy in early gastric cancer of upper body for prevention of gastroesophageal reflux disease and stenosis of anastomosis site. (23094231)
2012
9
Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea. (22967119)
2012
10
Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. (22317953)
2012
11
Inflammation in gastric adenocarcinoma of the cardia: how do EBV infection, Her2 amplification and cancer progression influence tumor-infiltrating lymphocytes? (21359545)
2011
12
Purulent pericarditis in patient with esophageal cancer presenting with cardiac tamponade. (19272728)
2011
13
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (22037551)
2011
14
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. (20699381)
2010
15
Metabolic targets of cardiac hormones' therapeutic anti-cancer effects. (20030620)
2010
16
HIF-1alpha and calcium signaling as targets for treatment of prostate cancer by cardiac glycosides. (20025575)
2009
17
Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer. (19455138)
2009
18
Pro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer. (19556815)
2009
19
Matters of the heart: cardiac toxicity of adjuvant systemic therapy for early-stage breast cancer. (18231644)
2008
20
Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. (17965056)
2008
21
Cardiac and kidney hormones cure up to 86% of human small-cell lung cancers in mice. (18717826)
2008
22
Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. (18287862)
2008
23
Radiologist experience and CT examination quality determine metastasis detection in patients with esophageal or gastric cardia cancer. (18523774)
2008
24
Risk factors for malnutrition after oesophageal and cardia cancer surgery. (18844265)
2008
25
GG genotype of cyclin D1 G870A polymorphism is associated with non-cardiac gastric cancer in a high-risk region of China. (18609126)
2008
26
Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction. (19120911)
2008
27
Patient demographics and lifestyle factors influencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden. (18434132)
2008
28
A rising trend of gastric cardia cancer in Gansu Province of China. (18501504)
2008
29
Cardiac toxicity in breast cancer survivors: review of potential cardiac problems. (18172247)
2008
30
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. (17671421)
2007
31
Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia. (17578895)
2007
32
An antireflux stent versus conventional stents for palliation of distal esophageal or cardia cancer: a randomized clinical study. (16960663)
2006
33
Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5. (16740726)
2006
34
Multimodal imaging of esophagus and cardia cancer before and after treatment. (16896560)
2006
35
Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population. (16045580)
2005
36
Five cardiac hormones decrease the number of human small-cell lung cancer cells. (15948900)
2005
37
Severe gemcitabine-induced capillary-leak syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease. (15630853)
2004
38
Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications. (14631371)
2004
39
Cardiac tamponade and superior vena cava syndrome in lung cancer--a case report. (15547656)
2004
40
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China. (14652285)
2003
41
Endoscopic mucosal resection for early cardia cancer by minimum laparotomy. (12620572)
2003
42
Inverse association between intake of cereal fiber and risk of gastric cardia cancer. (11159879)
2001
43
The p53 gene in patients under the age of 40 with gastric cancer: mutation rates are low but are associated with a cardiac location. (11040944)
2000
44
Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (9973227)
1999
45
Expression of nm23 in the primary tumor and the metastatic regional lymph nodes of patients with gastric cardiac cancer. (10430079)
1999
46
Surgery for esophageal and cardia cancer in Hungary: a nationwide retrospective five-year survey. (8726625)
1996
47
Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. (7742727)
1995
48
Cost of diseases in Brazil: breast cancer, enteritis, cardiac valve disease and bronchopneumonia. (8731274)
1995
49
Esophageal balloon cytology and subsequent risk of esophageal and gastric-cardia cancer in a high-risk Chinese population. (8206671)
1994
50
Evaluation of response to preoperative chemotherapy in esophageal and gastric cardia cancer using biphasic esophagrams and surgical-pathologic correlation. (3728374)
1986

Genetic Variations for Cardia Cancer

Expression for genes affiliated with Cardia Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cardia Cancer

Search GEO for disease gene expression data for Cardia Cancer.

Pathways for genes affiliated with Cardia Cancer

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Cardia Cancer according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GSTP1, GSTT1
210.0GSTT1, GSTM1
39.7GSTM1, GSTT1, GSTP1
4
Glutathione metabolism
Hide members
9.7GSTM1, GSTT1, GSTP1
5
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9.7CDKN2A, MDM2
6
Hide members
9.7GSTP1, TP53
7
Hide members
9.7GSTP1, CYP2E1, CYP1A1
8
Acetaminophen metabolism
Hide members
9.7CYP1A1, CYP2E1, GSTP1
9
Hide members
9.7MDM2, TP53
10
Hide members
9.7DYNC1I2
11
Hide members
9.6TYMS, MTHFR, MTRR
12
Hide members
9.6MTRR, MTHFR, TYMS
13
Hide members
9.6MDM2, CYP1A1, CYP2E1
14
Hide members
9.4XRCC1, PARP1, PARP4
159.3TP53, TYMS, MTHFR
16
Hide members
9.3TP53, TYMS, MTHFR
17
Hide members
9.2XRCC1, MDM2, TYMS, CDKN2A
18
Transcription P53 signaling pathway
Hide members
9.2TP53, CDKN2A, MDM2
19
Hide members
9.2MDM2, CDKN2A, TP53
209.2TP53, CDKN2A, MDM2
219.2MDM2, CDKN2A, TP53
229.2MDM2, CDKN2A, TP53
239.2TP53, CDKN2A, MDM2
24
Naphthalene metabolism
Hide members
9.2GSTP1, GSTT1, GSTM1, CYP2E1, CYP1A1
25
Hide members
9.2CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
26
Hide members
9.0MTRR, CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
278.9GSTP1, TP53, CDKN2A, MDM2
28
Hide members
8.8TP53, CD44, CDKN2A, MDM2
298.8MDM2, CDKN2A, CD44, TP53
308.8MDM2, CDKN2A, CD44, TP53
31
Hide members
8.4PDHB, MTRR, MTHFR, TYMS, CD44, CYP1A1

Compounds for genes affiliated with Cardia Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Cardia Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1vincristine45 50 1112.5GSTM1
2egcg4510.4CYP2E1
3resveratrol45 60 11 2413.1GAST
4bpde4510.0GSTP1, MDM2, CYP1A1
5s-phenylmercapturic acid459.9GSTM1, CYP2E1, GSTT1, GSTP1
6vinylchloride459.9GSTM1, XRCC1, CYP2E1, GSTT1
71,3-butadiene459.8GSTM1, GSTT1, GSTP1, CYP2E1
81-hydroxypyrene459.8CYP2E1, CYP1A1, GSTM1, GSTT1
9methylchloride459.7GSTT1, GSTP1, GSTM1
10styrene459.7CYP2E1, GSTT1, GSTP1, GSTM1
11trichloroethylene459.6GSTM1, GSTP1, CYP2E1, GSTT1
12dichloromethane459.6TYMS, CYP2E1, GSTP1, GSTT1
13acetone459.5GSTP1, GSTT1, CYP2E1, CYP1A1, GSTM1
14mspi459.5XRCC1, CYP1A1, GSTT1, CYP2E1, GSTM1
15ifosfamide45 1110.5TYMS, MDM2, GSTT1, GSTP1, GSTM1
16h2o2459.4PARP1, CYP1A1, CDKN2A, CYP2E1
17chi 2459.4GSTT1, GSTM1, MTHFR, MDM2
18epoxide459.4GSTP1, GSTT1, GSTM1, CYP2E1, XRCC1, CYP1A1
19isoniazid50 45 1111.3CDKN2A, CD44, CYP2E1, GSTM1, GSTT1
20fluorouracil50 1110.2GSTP1, XRCC1, MTHFR, TYMS, TP53
21etoposide45 50 60 1112.2CD44, GSTP1, XRCC1, MDM2, TYMS, CYP2E1
22p003459.2XRCC1, MDM2, CD44, GSTM1, GSTT1, MTRR
23betacarotene459.1GSTM1, CYP2E1, XRCC1, MTHFR, CYP1A1
24aflatoxin b145 2410.1TP53, MDM2, GSTM1, CDKN2A, GSTT1
25gsts459.1GSTM1, CYP1A1, CYP2E1, XRCC1, GSTT1, GSTP1
26hydrochloric acid45 2410.0GSTP1, GSTT1, GAST, GSTM1
27bcnu459.0TP53, GSTT1, GSTP1, CDKN2A, PARP1
28p002459.0XRCC1, GSTT1, CD44, MTHFR, MDM2, GSTM1
29benzo(a)pyrene458.8GSTP1, GSTT1, GSTM1, CYP1A1, MDM2, XRCC1
30methotrexate45 50 1110.7GSTP1, TYMS, MDM2, GSTM1, MTHFR, MTRR
31ascorbic acid45 249.7GSTT1, GSTM1, CYP2E1, CYP1A1, MTHFR, XRCC1
32creatinine458.6XRCC1, GAST, TYMS, CDKN2A, CYP2E1, GSTM1
33docetaxel45 50 60 1111.5CDKN2A, TYMS, PARP1, TP53, MDM2, GSTP1
34adriamycin458.5GSTP1, CD44, TYMS, MDM2, CDKN2A, TP53
35camptothecin45 60 1110.5CDKN2A, TYMS, MDM2, XRCC1, PARP1, TP53
36valine458.4CYP1A1, CDKN2A, TYMS, MTHFR, MDM2, GSTM1
37oxaliplatin45 50 1110.3CYP1A1, TYMS, MTHFR, XRCC1, CYP2E1, TP53
38paclitaxel45 50 1110.3MDM2, TYMS, GSTP1, CD44, TP53, PARP1
395fluorouracil458.3GSTM1, TP53, CDKN2A, TYMS, XRCC1, MDM2
40irinotecan45 50 1110.2GSTP1, XRCC1, MDM2, MTHFR, TYMS, CDKN2A
41thymidylate458.1TP53, CDKN2A, TYMS, MTHFR, MTRR, MDM2
42folate458.0GSTP1, GSTT1, GSTM1, XRCC1, GAST, MTRR
43cyclophosphamide45 50 119.8MTHFR, XRCC1, MDM2, GSTM1, TP53, CYP2E1
44doxorubicin45 50 119.8GSTP1, GSTM1, TP53, PARP1, CD44, CDKN2A
45carboplatin45 50 119.7GSTP1, GSTT1, GSTM1, XRCC1, MDM2, MTHFR
46arginine457.6CDKN2A, TP53, CYP1A1, XRCC1, GSTT1, MDM2
47testosterone45 60 11 2410.6GSTM1, GAST, CYP1A1, MDM2, MTHFR, CYP2E1
48actinomycin d457.5TP53, PARP1, GSTP1, CYP1A1, CDKN2A, MDM2
49vegf457.1GSTP1, CDKN2A, PARP1, GAST, MDM2, TYMS
50cisplatin45 50 60 119.3GSTP1, MDM2, GSTT1, GSTM1, TP53, PARP1

GO Terms for genes affiliated with Cardia Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Cardia Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.1MDM2, CDKN2A, TP53
2mitochondrionGO:0057398.4GSTP1, TP53, CYP2E1, CYP1A1, CDKN2A, TYMS
3nucleoplasmGO:0056548.0XRCC1, MDM2, TYMS, CDKN2A, PARP1, TP53
4cytosolGO:0058296.8GSTP1, DYNC1I2, MDM2, MTRR, MTHFR, TYMS

Biological processes related to Cardia Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1methionine biosynthetic processGO:00908610.0MTRR, MTHFR
2glutathione derivative biosynthetic processGO:19016879.9GSTM1, GSTT1, GSTP1
3response to vitamin AGO:0331899.9CYP1A1, TYMS
4glutathione metabolic processGO:0067499.8GSTP1, GSTT1, GSTM1
5base-excision repairGO:0062849.5XRCC1, PARP1, TP53
6response to antibioticGO:0466779.5TP53, CYP1A1, MDM2
7negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435189.5MDM2, CD44
8replicative senescenceGO:0903999.4CDKN2A, TP53
9xenobiotic metabolic processGO:0068059.2MTRR, CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
10DNA repairGO:0062819.1PARP4, PARP1, TYMS, XRCC1
11response to drugGO:0424938.6GSTT1, XRCC1, MDM2, TYMS, CYP1A1, CYP2E1
12small molecule metabolic processGO:0442817.9PDHB, MTRR, MTHFR, TYMS, CD44, CYP1A1

Molecular functions related to Cardia Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, andGO:01670910.0CYP2E1, MTRR
2glutathione transferase activityGO:0043649.7GSTM1, GSTT1, GSTP1
3MDM2/MDM4 family protein bindingGO:0973719.2TP53, CDKN2A
4p53 bindingGO:0020399.1TP53, CDKN2A, MDM2
5enzyme bindingGO:0198998.4GSTM1, TP53, PARP4, CYP2E1, CYP1A1, MDM2

Products for genes affiliated with Cardia Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardia Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet