MCID: CRD005
MIFTS: 53

Cardia Cancer malady

Cancer diseases, Gastrointestinal diseases categories

Summaries for Cardia Cancer

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32MalaCards
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MalaCards: Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to esophagitis and esophageal cancer. An important gene associated with Cardia Cancer is XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The compounds vincristine and egcg have been mentioned in the context of this disorder. Affiliated tissues include t cells, spleen and heart, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Cardia Cancer

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

cardia cancer 8
malignant neoplasm of cardia of stomach 8
malignant neoplasm of cardia 60
ca cardia - stomach 8
cardiac carcinoma 60


External Ids:

Disease Ontology8 DOID:10548
ICD9CM27 151.0
ICD1025 C16.0

Related Diseases for Cardia Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cardia Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.0GAST
2esophageal cancer31.0MDM2, CDKN2A, CYP1A1, TP53, GSTP1
3gastric adenocarcinoma30.2GSTT1, GSTM1, CD44, TYMS, GAST
4adenocarcinoma30.2CDKN2A, TYMS, MDM2, GAST, XRCC1, CD44
5gastritis30.0TP53, GAST
6stomach cancer30.0GAST, TYMS, CDKN2A, CD44, TP53, GSTP1
7gastric cardia adenocarcinoma10.2
8esophageal disease10.0
9heart cancer10.0
10lipoma10.0
11lymph node cancer10.0
12spleen cancer10.0
13meningioma10.0GSTT1
14liver cirrhosis10.0CYP2E1
15hepatitis b10.0GSTT1
16galactosemia10.0CYP2E1
17glaucoma10.0GSTP1
18primary open angle glaucoma10.0GSTM1
19malignant pleural mesothelioma10.0TYMS
20motor neuron disease10.0GSTT1
21duodenitis10.0GAST
22fatty liver disease10.0CYP2E1
23hepatoblastoma10.0CYP2E1
24biliary tract neoplasm10.0TYMS
25multiple sclerosis10.0GSTM1
26cataract10.0GSTT1
27chondrosarcoma10.0MDM2
28schistosomiasis10.0GSTM1
29eclampsia10.0MTHFR
30hypertension10.0MTHFR
31fibrosarcoma10.0MDM2
32myeloid leukemia10.0PARP1
33ependymoma10.0MDM2
34schizophrenia10.0MTHFR
35gastroesophageal reflux disease10.0GAST
36pancreatitis10.0GSTP1, CYP2E1
37arthritis10.0CD44
38pancreas disease10.0GAST
39myelodysplastic syndromes10.0GSTT1, GSTM1
40gastroduodenitis10.0GAST
41cerebrovascular disease10.0MTHFR
42neutropenia10.0TYMS
43atopy10.0GSTP1, GSTT1
44lichen sclerosus10.0CD44
45stroke, ischemic10.0MTHFR
46infertility10.0CYP1A1, GSTT1
47deficiency anemia10.0TYMS, GSTM1
48asbestosis10.0GSTM1, GSTT1
49down syndrome10.0MTHFR, MTRR
50primary hyperoxaluria10.0CD44

Graphical network of the top 20 diseases related to Cardia Cancer:



Diseases related to cardia cancer

Clinical Features for Cardia Cancer

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Drugs & Therapeutics for Cardia Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cardia Cancer

Drug clinical trials:

Search ClinicalTrials for Cardia Cancer

Search NIH Clinical Center for Cardia Cancer

Search CenterWatch for Cardia Cancer

Genetic Tests for Cardia Cancer

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Anatomical Context for Cardia Cancer

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32MalaCards
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MalaCards organs/tissues related to Cardia Cancer:

32
T cells, Spleen, Heart, Lymph node

Animal Models for Cardia Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cardia Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CYP2E1, CDKN2A, MDM2, GAST
2MP:00053769.0XRCC1, GAST, MTRR, MTHFR, GSTT1
3MP:00030128.5MDM2, CDKN2A, CD44, CYP1A1, TP53
4MP:00107718.3MDM2, CDKN2A, PARP1, TP53, GSTP1
5MP:00053708.2TP53, CYP2E1, CYP1A1, CD44, CDKN2A, MDM2
6MP:00053787.1XRCC1, MDM2, MTRR, MTHFR, CDKN2A, CD44
7MP:00107685.8MDM2, GAST, XRCC1, DYNC1I2, MTHFR, CDKN2A

Publications for Cardia Cancer

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Sources:
50PubMed
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Articles related to Cardia Cancer:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou. (23803050)
2013
2
Trend breaks in incidence of non-cardia gastric cancer in the Netherlands. (24309073)
2013
3
Nuclear Nano-architecture Markers of Gastric Cardia and Upper Squamous Esophagus Detect Esophageal Cancer "Field Effect". (24155774)
2013
4
Consideration of cardia preserving proximal gastrectomy in early gastric cancer of upper body for prevention of gastroesophageal reflux disease and stenosis of anastomosis site. (23094231)
2012
5
Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer. (22580669)
2012
6
Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea. (22967119)
2012
7
Gastric cardia cancer: how much is it from fat? (22915196)
2012
8
Inflammation in gastric adenocarcinoma of the cardia: how do EBV infection, Her2 amplification and cancer progression influence tumor-infiltrating lymphocytes? (21359545)
2011
9
Impact of concentration of oesophageal and gastric cardia cancer surgery on long-term population-based survival. (21509748)
2011
10
Is cardia cancer aetiologically different from distal stomach cancer? (21150780)
2011
11
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (22037551)
2011
12
Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. (21184266)
2011
13
A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area. (20603233)
2010
14
Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers. (21155014)
2010
15
The prognosis of gastric cardia cancer after R0 resection. (19837398)
2010
16
Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers. (19618282)
2009
17
Nurse-led follow-up of patients after oesophageal or gastric cardia cancer surgery: a randomised trial. (19066612)
2009
18
En bloc resection of cardia cancer and lipoma with endoscopic submucosal dissection. (18657491)
2009
19
Video: minimally invasive Ivor-Lewis esophagogastrectomy for gastric cardia cancer. (19452220)
2009
20
Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer. (17492381)
2008
21
Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. (17965056)
2008
22
Radiologist experience and CT examination quality determine metastasis detection in patients with esophageal or gastric cardia cancer. (18523774)
2008
23
Risk factors for malnutrition after oesophageal and cardia cancer surgery. (18844265)
2008
24
Relationship between p53 expression and gastric cancers in cardia and antrum. (18759514)
2008
25
Patient demographics and lifestyle factors influencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden. (18434132)
2008
26
A rising trend of gastric cardia cancer in Gansu Province of China. (18501504)
2008
27
Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes. (17444864)
2007
28
Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer. (17383456)
2007
29
Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. (17638920)
2007
30
Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. (17317788)
2007
31
An antireflux stent versus conventional stents for palliation of distal esophageal or cardia cancer: a randomized clinical study. (16960663)
2006
32
Multimodal imaging of esophagus and cardia cancer before and after treatment. (16896560)
2006
33
Cytokeratin phenotyping does not help in distinguishing oesophageal adenocarcinoma from cancer of the gastric cardia. (15976339)
2005
34
Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer. (15533591)
2004
35
Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes. (15801491)
2004
36
Risk factors for the gastric cardia cancer: a case-control study in Fujian Province. (12532434)
2003
37
No changing trends in incidence of gastric cardia cancer in Korea. (12589087)
2003
38
Alterations of p53 and PCNA in cancer and adjacent tissues from concurrent carcinomas of the esophagus and gastric cardia in the same patient in Linzhou, a high incidence area for esophageal cancer in northern China. (12508343)
2003
39
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China. (14652285)
2003
40
Inverse association between intake of cereal fiber and risk of gastric cardia cancer. (11159879)
2001
41
A favorable impact of preoperative FPLC chemotherapy on patients with gastric cardia cancer. (10671664)
2000
42
Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden. (10861464)
2000
43
Double-stapled esophagogastric anastomosis for resection of esophagogastric or cardia cancer: new application for an old technique. (10488828)
1999
44
Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas. (9973227)
1999
45
Evaluating gastric cancer misclassification: a potential explanation for the rise in cardia cancer incidence. (10328109)
1999
46
Re: Evaluating gastric cancer misclassification: a potential explanation for the rise in cardia cancer incidence. (10491439)
1999
47
Surgery for esophageal and cardia cancer in Hungary: a nationwide retrospective five-year survey. (8726625)
1996
48
Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. (7742727)
1995
49
Inoperable oesophageal and cardia cancer. Benefits from Celestin intubation. (2438761)
1987
50
Evaluation of response to preoperative chemotherapy in esophageal and gastric cardia cancer using biphasic esophagrams and surgical-pathologic correlation. (3728374)
1986

Genetic Variations for Cardia Cancer

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Expression for genes affiliated with Cardia Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardia Cancer

Search GEO for disease gene expression data for Cardia Cancer.

Pathways for genes affiliated with Cardia Cancer

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Cardia Cancer according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GSTP1, GSTT1
210.0GSTT1, GSTM1
39.7GSTM1, GSTT1, GSTP1
4
Glutathione metabolism
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9.7GSTM1, GSTT1, GSTP1
5
Hide members
9.7CDKN2A, MDM2
6
Hide members
9.7GSTP1, TP53
7
Hide members
9.7GSTP1, CYP2E1, CYP1A1
8
Acetaminophen metabolism
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9.7CYP1A1, CYP2E1, GSTP1
9
Hide members
9.7MDM2, TP53
10
Hide members
9.7DYNC1I2
11
Hide members
9.6TYMS, MTHFR, MTRR
12
Hide members
9.6MTRR, MTHFR, TYMS
13
Hide members
9.6MDM2, CYP1A1, CYP2E1
14
Hide members
9.4XRCC1, PARP1, PARP4
159.3TP53, TYMS, MTHFR
16
Hide members
9.3TP53, TYMS, MTHFR
17
Hide members
9.2XRCC1, MDM2, TYMS, CDKN2A
18
Transcription P53 signaling pathway
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9.2TP53, CDKN2A, MDM2
19
Hide members
9.2MDM2, CDKN2A, TP53
209.2TP53, CDKN2A, MDM2
219.2MDM2, CDKN2A, TP53
229.2MDM2, CDKN2A, TP53
239.2TP53, CDKN2A, MDM2
24
Naphthalene metabolism
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9.2GSTP1, GSTT1, GSTM1, CYP2E1, CYP1A1
25
Hide members
9.2CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
26
Hide members
9.0MTRR, CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
278.9GSTP1, TP53, CDKN2A, MDM2
28
Hide members
8.8TP53, CD44, CDKN2A, MDM2
298.8MDM2, CDKN2A, CD44, TP53
308.8MDM2, CDKN2A, CD44, TP53
31
Hide members
8.4PDHB, MTRR, MTHFR, TYMS, CD44, CYP1A1

Compounds for genes affiliated with Cardia Cancer

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Cardia Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.5GSTM1
2egcg4410.4CYP2E1
3resveratrol44 59 11 2413.1GAST
4bpde4410.0GSTP1, MDM2, CYP1A1
5s-phenylmercapturic acid449.9GSTM1, CYP2E1, GSTT1, GSTP1
6vinylchloride449.9GSTM1, XRCC1, CYP2E1, GSTT1
71,3-butadiene449.8GSTM1, GSTT1, GSTP1, CYP2E1
81-hydroxypyrene449.8CYP2E1, CYP1A1, GSTM1, GSTT1
9methylchloride449.7GSTT1, GSTP1, GSTM1
10styrene449.7CYP2E1, GSTT1, GSTP1, GSTM1
11trichloroethylene449.6GSTM1, GSTP1, CYP2E1, GSTT1
12dichloromethane449.6TYMS, CYP2E1, GSTP1, GSTT1
13acetone449.5GSTP1, GSTT1, CYP2E1, CYP1A1, GSTM1
14mspi449.5XRCC1, CYP1A1, GSTT1, CYP2E1, GSTM1
15ifosfamide44 1110.5TYMS, MDM2, GSTT1, GSTP1, GSTM1
16h2o2449.4PARP1, CYP1A1, CDKN2A, CYP2E1
17chi 2449.4GSTT1, GSTM1, MTHFR, MDM2
18epoxide449.4GSTP1, GSTT1, GSTM1, CYP2E1, XRCC1, CYP1A1
19isoniazid49 44 1111.3CDKN2A, CD44, CYP2E1, GSTM1, GSTT1
20fluorouracil49 1110.2GSTP1, XRCC1, MTHFR, TYMS, TP53
21etoposide44 49 59 1112.2CD44, GSTP1, XRCC1, MDM2, TYMS, CYP2E1
22p003449.2XRCC1, MDM2, CD44, GSTM1, GSTT1, MTRR
23betacarotene449.1GSTM1, CYP2E1, XRCC1, MTHFR, CYP1A1
24aflatoxin b144 2410.1TP53, MDM2, GSTM1, CDKN2A, GSTT1
25gsts449.1GSTM1, CYP1A1, CYP2E1, XRCC1, GSTT1, GSTP1
26hydrochloric acid44 2410.0GSTP1, GSTT1, GAST, GSTM1
27bcnu449.0TP53, GSTT1, GSTP1, CDKN2A, PARP1
28p002449.0XRCC1, GSTT1, CD44, MTHFR, MDM2, GSTM1
29benzo(a)pyrene448.8GSTP1, GSTT1, GSTM1, CYP1A1, MDM2, XRCC1
30methotrexate44 49 1110.7GSTP1, TYMS, MDM2, GSTM1, MTHFR, MTRR
31ascorbic acid44 249.7GSTT1, GSTM1, CYP2E1, CYP1A1, MTHFR, XRCC1
32creatinine448.6XRCC1, GAST, TYMS, CDKN2A, CYP2E1, GSTM1
33docetaxel44 49 59 1111.5CDKN2A, TYMS, PARP1, TP53, MDM2, GSTP1
34adriamycin448.5GSTP1, CD44, TYMS, MDM2, CDKN2A, TP53
35camptothecin44 59 1110.5CDKN2A, TYMS, MDM2, XRCC1, PARP1, TP53
36valine448.4CYP1A1, CDKN2A, TYMS, MTHFR, MDM2, GSTM1
37oxaliplatin44 49 1110.3CYP1A1, TYMS, MTHFR, XRCC1, CYP2E1, TP53
38paclitaxel44 49 1110.3MDM2, TYMS, GSTP1, CD44, TP53, PARP1
395fluorouracil448.3GSTM1, TP53, CDKN2A, TYMS, XRCC1, MDM2
40irinotecan44 49 1110.2GSTP1, XRCC1, MDM2, MTHFR, TYMS, CDKN2A
41thymidylate448.1TP53, CDKN2A, TYMS, MTHFR, MTRR, MDM2
42folate448.0GSTP1, GSTT1, GSTM1, XRCC1, GAST, MTRR
43cyclophosphamide44 49 119.8MTHFR, XRCC1, MDM2, GSTM1, TP53, CYP2E1
44doxorubicin44 49 119.8GSTP1, GSTM1, TP53, PARP1, CD44, CDKN2A
45carboplatin44 49 119.7GSTP1, GSTT1, GSTM1, XRCC1, MDM2, MTHFR
46arginine447.6CDKN2A, TP53, CYP1A1, XRCC1, GSTT1, MDM2
47testosterone44 59 11 2410.6GSTM1, GAST, CYP1A1, MDM2, MTHFR, CYP2E1
48actinomycin d447.5TP53, PARP1, GSTP1, CYP1A1, CDKN2A, MDM2
49vegf447.1GSTP1, CDKN2A, PARP1, GAST, MDM2, TYMS
50cisplatin44 49 59 119.3GSTP1, MDM2, GSTT1, GSTM1, TP53, PARP1

GO Terms for genes affiliated with Cardia Cancer

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Sources:
16Gene Ontology
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Cellular components related to Cardia Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.1MDM2, CDKN2A, TP53
2mitochondrionGO:0057398.4GSTP1, TP53, CYP2E1, CYP1A1, CDKN2A, TYMS
3nucleoplasmGO:0056548.0XRCC1, MDM2, TYMS, CDKN2A, PARP1, TP53
4cytosolGO:0058296.8GSTP1, DYNC1I2, MDM2, MTRR, MTHFR, TYMS

Biological processes related to Cardia Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1methionine biosynthetic processGO:00908610.0MTRR, MTHFR
2glutathione derivative biosynthetic processGO:19016879.9GSTM1, GSTT1, GSTP1
3response to vitamin AGO:0331899.9CYP1A1, TYMS
4glutathione metabolic processGO:0067499.8GSTP1, GSTT1, GSTM1
5base-excision repairGO:0062849.5XRCC1, PARP1, TP53
6response to antibioticGO:0466779.5TP53, CYP1A1, MDM2
7negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435189.5MDM2, CD44
8replicative senescenceGO:0903999.4CDKN2A, TP53
9xenobiotic metabolic processGO:0068059.2MTRR, CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1
10DNA repairGO:0062819.1PARP4, PARP1, TYMS, XRCC1
11response to drugGO:0424938.6GSTT1, XRCC1, MDM2, TYMS, CYP1A1, CYP2E1
12small molecule metabolic processGO:0442817.9PDHB, MTRR, MTHFR, TYMS, CD44, CYP1A1

Molecular functions related to Cardia Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, andGO:01670910.0CYP2E1, MTRR
2glutathione transferase activityGO:0043649.7GSTM1, GSTT1, GSTP1
3MDM2/MDM4 family protein bindingGO:0973719.2TP53, CDKN2A
4p53 bindingGO:0020399.1TP53, CDKN2A, MDM2
5enzyme bindingGO:0198998.4GSTM1, TP53, PARP4, CYP2E1, CYP1A1, MDM2

Products for genes affiliated with Cardia Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardia Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet