MCID: CRD016
MIFTS: 37

Cardiac Rupture malady

Summaries for Cardiac Rupture

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Myocardial rupture (or heart rupture) is a laceration or tearing of the walls of the ventricles or atria... more...

MalaCards: Cardiac Rupture, also known as myocardial rupture, is related to acute myocardial infarction and coronary artery disease,. An important gene associated with Cardiac Rupture is CHKB (choline kinase beta), and among its related pathways is A-beta Plaque Formation & APP Metabolism . The compounds norepinephrine and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are behavior/neurological and muscle.

Aliases & Classifications for Cardiac Rupture

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Aliases & Descriptions:

cardiac rupture 43 45
myocardial rupture 61


Related Diseases for Cardiac Rupture

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.1NPPB, CRP, CHKB, MMP9, PLAT
2coronary artery disease,30.1NPPB, CRP, CHKB, MMP9, PLAT
3thromboembolism29.9PLAT
4stroke, ischemic29.9PLAT
5abdominal aortic aneurysm29.9MMP9
6aortic aneurysm29.9CRP
7systemic lupus erythematosus29.9CRP
8coronary heart disease29.9PLAT, CHKB, CRP, NPPB
9cardiac tamponade10.4
10hemopericardium10.3
11angiosarcoma10.2
12aortic valve stenosis10.2
13left ventricular outflow tract obstruction10.2
14septal myocardial infarction10.1
15ventricular septal defect10.1
16inferior myocardial infarction10.0
17addison's disease10.0
18myositis10.0CHKB
19sleep disorder10.0CHKB
20antiphospholipid syndrome10.0PLAT
21neuroleptic malignant syndrome10.0CHKB
22brain edema10.0MMP9
23hypersensitivity reaction type ii disease10.0PRF1
24sinusitis10.0FLNC
25interstitial lung disease10.0MMP9
26carotid artery disease10.0PLAT
27endocarditis10.0PRF1
28cystic fibrosis10.0FLNC
29periodontitis10.0MMP9
30hemiplegia10.0PLAT
31age related macular degeneration10.0PLAT
32pelvic inflammatory disease10.0CRP
33hypertensive heart disease10.0NPPB
34periodontal disease10.0CRP
35obesity10.0CRP
36peritonitis10.0CRP
37polycystic ovary syndrome10.0CRP
38galactosemia10.0CRP
39hyperglycemia10.0CRP
40respiratory failure10.0CRP
41endophthalmitis10.0PLAT, PRF1
42hypothyroidism10.0CHKB
43middle ear cholesteatoma10.0MMP9, CHKB
44dilated cardiomyopathy10.0CHKB, NPPB
45ulcerative colitis10.0CRP
46cardiogenic shock10.0NPPB, PLAT
47pulmonary embolism10.0NPPB, PLAT
48limb-girdle muscular dystrophy10.0FLNC, CHKB
49bacteriuria10.0CRP
50essential hypertension10.0PLAT, NPPB

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to cardiac rupture

Clinical Features for Cardiac Rupture

Drugs & Therapeutics for Cardiac Rupture

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cardiac Rupture

Drug clinical trials:

Search ClinicalTrials for Cardiac Rupture

Search NIH Clinical Center for Cardiac Rupture

Search CenterWatch for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

Sources:
33MalaCards
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MalaCards organs/tissues related to Cardiac Rupture:

33
Liver, Brain, Lung, Heart

Animal Models for Cardiac Rupture or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cardiac Rupture:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.6FLNC, PRF1, CHKB, MMP9, PLAT, TRIM54
2MP:00053697.2FLNC, CHKB, TRIM54, MMP9, PLAT, NPPB
3MP:00053856.7PLAT, PMM2, NPPB, CRP, FLNC, TRIM54

Publications for Cardiac Rupture

Sources:
51PubMed
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Articles related to Cardiac Rupture:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Right massive haemothorax as the presentation of blunt cardiac rupture: the pitfall of coexisting pericardial laceration. (24218497)
2014
2
Acute myocardial infarction and swinging heart: not always a cardiac rupture--haemopericardium due to infiltrative lung cancer. (22645189)
2012
3
Simple and quick repair of cardiac rupture due to blunt chest trauma. (22371946)
2012
4
Glycogen synthase kinase-3I+ limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. (22086876)
2012
5
Blunt cardiac rupture: a challenging diagnosis. (23265113)
2012
6
Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. (21493899)
2011
7
Survival of blunt cardiac rupture after asystolic arrest: a case report. (19359944)
2009
8
Levosimendan in heart failure after surgical repair of cardiac rupture. (19202525)
2009
9
Cardiac tamponade due to rupture of coronary artery fistulas with a giant aneurysm containing a free floating ball thrombus: a case report. (17685030)
2007
10
Cardiac tamponade due to a ruptured solitary mediastinal varix: a case report. (17389211)
2007
11
Cardiac tamponade due to spontaneous rupture of large coronary artery aneurysm. (17005893)
2006
12
Cardiac rupture during stress echocardiography. (16308600)
2005
13
Cardiac rupture during contrast-enhanced dobutamine stress echocardiography. (15686792)
2005
14
Effect of reperfusion therapy on cardiac rupture after myocardial infarction in Japanese. (15118282)
2004
15
Cardiac rupture complicating acute myocardial infarction in the direct percutaneous coronary intervention reperfusion era. (12907544)
2003
16
Angiosarcoma causing cardiac rupture. (11552279)
2001
17
Traumatic cardiac rupture with acute ascites. (11030130)
2000
18
An occurrence of cardiac rupture in a capercaillie (Tetrao urogallus) probably induced by myocardial infarction. (10737669)
2000
19
Oozing type cardiac rupture repaired with percutaneous injection of fibrin-glue into the pericardial space: case report. (10783056)
2000
20
Diagnosis of cardiac rupture with the use of contrast-enhanced echocardiography. (10980090)
2000
21
Diagnosis and treatment of blunt cardiac rupture. (9090319)
1997
22
Cardiac rupture complicating cerebral intraarterial thrombolytic therapy. (9403446)
1997
23
Upper torso cyanosis: a marker for blunt cardiac rupture. (9148985)
1997
24
Postinfarction cardiac rupture and electromechanical dissociation. (9139518)
1997
25
Acute ascites with blunt cardiac rupture. (8595574)
1996
26
Blunt cardiac rupture. The Emanuel Trauma Center experience. (7632145)
1995
27
Role of stress concentration in the pathogenesis of cardiac rupture following acute myocardial infarction. (7585273)
1995
28
Adjunctive technique for control of hemorrhage during repair of cardiac rupture. (7598597)
1995
29
A partial defect in technetium-99m pyrophosphate image suggesting cardiac rupture following acute myocardial infarction. (1533369)
1992
30
Cardiac rupture from blunt trauma. (1610328)
1992
31
Delayed cardiac rupture due to blunt chest trauma. (1882780)
1991
32
Cardiac rupture in blunt trauma without external signs of chest injury. (2618043)
1989
33
Left ventricular pseudopseudoaneurysm: angiographic features and surgical treatment of impending cardiac rupture. (3414499)
1988
34
Postinfarction cardiac rupture: a challenge to try surgical reparation. (3609624)
1987
35
Association of eosinophils with cardiac rupture. (3997134)
1985
36
Aortic stenosis, myocardial infarction and cardiac rupture: an unusual triad. (15227103)
1984
37
Cardiac rupture following intracoronary streptokinase. (6883501)
1983
38
Cardiac sarcoidosis with spontaneous rupture of the right ventricle. (7118028)
1982
39
Cardiac rupture and ventricular septal defect in isolated right coronary artery disease. (7471868)
1981
40
Cardiac rupture complicating myocardial infarction. (7327001)
1981
41
Vasopressors and cardiac rupture. (7369139)
1980
42
Post-infarction cardiac rupture. (1018649)
1976
43
Cardiac rupture complicating acute myocardial infarction in presence of normal electrocardiogram. (1157545)
1975
44
Cardiac rupture. Three operations with two long-term survivals. (4565468)
1973
45
Postinfarction cardiac rupture. (5285998)
1971
46
Clinical and electrocardiographic features of cardiac rupture following acute myocardial infarction. (5089848)
1971
47
Clinical and pathologic features of postinfarction cardiac rupture. (5380841)
1969
48
Cardiac rupture in acute myocardial infarction. (5949810)
1966
49
The influence of anticoagulant therapy on the occurrence of cardiac rupture and hemopericardium following heart infarction. I. A study of 89 cases of hemopericardium (81 of them cardiac ruptures). (13545172)
1958
50
Rupture of cardiac muscle with recent coronary thrombosis: 1. Cardiac tamponade; 2. Interventricular septal perforation; 3. Ruptured papillary muscle of the mitral valve. (13117508)
1954

Genetic Variations for Cardiac Rupture

Expression for genes affiliated with Cardiac Rupture

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for genes affiliated with Cardiac Rupture

Sources:
53R&D Systems
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Pathways related to Cardiac Rupture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PLAT, MMP9

Compounds for genes affiliated with Cardiac Rupture

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Cardiac Rupture according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.6CHKB
2alpha tocopherol4510.5CHKB
3thallium4510.0CHKB, NPPB
4aprotinin45 1111.0PLAT, NPPB
5p0034510.0PLAT, NPPB
6enalaprilat459.9PLAT, NPPB
7quinapril45 1110.8PLAT, CRP
8ceftriaxone45 1110.8CRP, PLAT
9dobutamine45 29 1111.7PLAT, CHKB, NPPB
10ptca459.7NPPB, CHKB, PLAT
11spec-t459.7PLAT, CHKB, NPPB
12trapidil459.7PLAT, MMP9
13phosphorylcholine45 2410.7CRP, CHKB
14omapatrilat459.7PLAT, MMP9
15abciximab45 1110.6PLAT, CHKB, CRP
16clopidogrel50 45 11 2412.6CRP, CHKB, PLAT
17ramipril45 1110.6CRP, NPPB
18thyroxine45 2410.5NPPB, CHKB, PLAT
19atenolol45 29 50 11 2413.4NPPB, CRP
20tirofiban45 1110.4PLAT, CRP, NPPB
21perindopril45 50 1111.4PLAT, CRP, NPPB
22valsartan45 60 29 1112.4CRP, NPPB
23pravastatin45 50 29 11 2413.4NPPB, CRP, CHKB
24uric acid45 2410.4NPPB, CRP, CHKB
25losartan45 50 29 1112.4PLAT, CRP, NPPB
26prednisolone45 29 1111.3CHKB, CRP, NPPB
27homocysteine45 2410.3PLAT, CRP, NPPB
28telmisartan45 29 1111.2NPPB, CRP
29prostacyclin459.2PLAT, CRP, NPPB
30gabexate mesilate459.1PLAT, MMP9, CRP
31nitroglycerin45 1110.1NPPB, CRP, CHKB, PLAT
32aspirin45 50 29 2412.1NPPB, CRP, CHKB, PLAT
33nacl459.0CHKB, PRF1, NPPB
34fosinopril45 1110.0NPPB, CRP, MMP9
358-isoprostane458.9MMP9, CRP, NPPB
36pioglitazone45 50 29 1111.9NPPB, CRP, MMP9
37cyclosporin a45 29 6010.8PLAT, MMP9, CHKB, NPPB
38rosiglitazone45 50 29 11 2412.8NPPB, CRP, MMP9
39cholesterol45 29 11 2411.8PLAT, CHKB, PRF1, CRP
40fluvastatin45 50 29 1111.8CRP, CHKB, MMP9, PLAT
41simvastatin45 50 60 29 11 2413.8CRP, CHKB, MMP9, PLAT
42cyclophosphamide45 50 1110.8NPPB, CRP, MMP9
43fibrinogen458.8CRP, CHKB, MMP9, PLAT
44aspartate458.7CRP, CHKB, MMP9, PLAT
45p002458.6NPPB, CRP, MMP9, PLAT
46lactate458.5NPPB, CRP, CHKB, MMP9
47atorvastatin45 50 29 11 2412.3PLAT, MMP9, CHKB, CRP, NPPB
48creatinine458.3NPPB, CRP, CHKB, MMP9, PLAT
49testosterone45 60 11 2411.2MMP9, CHKB, CRP, NPPB
50calcium45 50 11 2410.6NPPB, CRP, FLNC, PRF1, CHKB, MMP9

GO Terms for genes affiliated with Cardiac Rupture

Sources:
16Gene Ontology
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Cellular components related to Cardiac Rupture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2PLAT, MMP9, CRP, NPPB
2extracellular regionGO:0055767.5PLAT, MMP9, PRF1, CRP, NPPB

Products for genes affiliated with Cardiac Rupture

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  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiac Rupture

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet