MCID: CRD016
MIFTS: 34

Cardiac Rupture malady

Categories: Rare diseases

Aliases & Classifications for Cardiac Rupture

Aliases & Descriptions for Cardiac Rupture:

Name: Cardiac Rupture 50 52
Myocardial Rupture 69

Classifications:



Summaries for Cardiac Rupture

MalaCards based summary : Cardiac Rupture, also known as myocardial rupture, is related to artery disease and lupus erythematosus. An important gene associated with Cardiac Rupture is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cell adhesion_ECM remodeling. The drugs Ramipril and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are cardiovascular system and muscle

Related Diseases for Cardiac Rupture

Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Related Disease Score Top Affiliating Genes
1 artery disease 29.6 CRP PRF1
2 lupus erythematosus 29.4 CRP PLAT
3 myocardial infarction 10.5
4 acute myocardial infarction 10.3
5 scleroderma, familial progressive 10.2 CXCL8 ELANE
6 infectious anterior uveitis 10.2 CXCL8 ELANE
7 omsk hemorrhagic fever 10.2 CXCL8 ELANE
8 unilateral multicystic dysplastic kidney 10.2 CRP PLAT
9 chronic fungal otitis externa 10.2 CRP PLAT
10 secretory diarrhea myopathy and deafness 10.2 CRP PLAT
11 subacute glomerulonephritis 10.2 CRP ELANE
12 sosby syndrome 10.2 CRP CXCL8
13 capillary leak syndrome 10.2 CRP CXCL8
14 inferolateral myocardial infarct 10.2 CHKB PLAT
15 umbilical hernia 10.2 CRP FLNC
16 cicatricial lagophthalmos 10.2 CRP CXCL8
17 tuberculous salpingitis 10.2 CRP FLNC
18 hidradenitis 10.2 CRP CXCL8
19 xerophthalmia 10.2 CRP PLAT
20 appendiceal l-cell glucagon-like peptide producing tumor 10.2 CRP CXCL8
21 fallopian tube serous adenocarcinoma 10.2 CRP CXCL8
22 bullous retinoschisis 10.2 CXCL8 PRF1
23 carbuncle 10.2 CXCL8 PRF1
24 calpainopathy 10.2 CXCL8 ELANE
25 prostate embryonal rhabdomyosarcoma 10.2 CRP FLNC
26 lateral cystocele 10.2 CXCL8 PRF1
27 neuropathy 10.2 CRP CXCL8
28 mixed mineral dust pneumoconiosis 10.1 CRP CXCL8
29 wilkes stevenson syndrome 10.1 CRP CXCL8
30 strawberry gallbladder 10.1 CRP CXCL8
31 allergic bronchopulmonary aspergillosis 10.1 CRP CXCL8
32 stenosis of lacrimal sac 10.1 CXCL8 ELANE PLAT
33 atrophy of prostate 10.1 CRP CXCL8
34 adnp syndrome 10.1 CXCL8 ELANE
35 inappropriate adh syndrome 10.1 CXCL8 PRF1
36 spontaneous ocular nystagmus 10.1 CXCL8 ELANE FLNC
37 asbestosis 10.1 CRP CXCL8 PLAT
38 myiasis 10.1 CRP CXCL8
39 alcoholic hepatitis 10.1 CXCL8 ELANE
40 retinitis pigmentosa 51 10.1 CRP CXCL8 ELANE
41 infancy electroclinical syndrome 10.1 CRP CXCL8 ELANE
42 bare lymphocyte syndrome, type i 10.1 CRP CXCL8 ELANE
43 lacrimal system cancer 10.1 CRP CXCL8 ELANE
44 histiocytosis 10.1 CRP CXCL8 ELANE
45 major depressive disorder and accelerated response to antidepressant drug treatment 10.1 CRP CXCL8 ELANE
46 rectum squamous cell carcinoma 10.1 CRP CXCL8 ELANE
47 sydenham chorea 10.0 CRP ELANE PLAT
48 urinary bladder posterior wall cancer 10.0 CHKB CRP
49 choroiditis 10.0 CRP CXCL8
50 adult t-cell leukemia 10.0 CHKB CRP PLAT

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to Cardiac Rupture

Symptoms & Phenotypes for Cardiac Rupture

MGI Mouse Phenotypes related to Cardiac Rupture:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 FLNC PLAT PMM2 PRF1 TRIM54 CRP
2 muscle MP:0005369 9.02 CHKB FLNC PLAT PMM2 TRIM54

Drugs & Therapeutics for Cardiac Rupture

Drugs for Cardiac Rupture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 222)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 4 87333-19-5 5362129
2
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
3
Pravastatin Approved Phase 4 81093-37-0 54687
4
Nebivolol Approved, Investigational Phase 4,Phase 3 152520-56-4, 99200-09-6, 118457-14-0 71301
5
Aspirin Approved, Vet_approved Phase 4,Phase 1 50-78-2 2244
6
Dinoprostone Approved Phase 4,Phase 3 363-24-6 5280360
7
Atenolol Approved Phase 4,Phase 2 29122-68-7 2249
8
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
10
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
11
Eptifibatide Approved, Investigational Phase 4,Phase 3 188627-80-7 123610
12
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
13
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
14 sodium fluoride Approved Phase 4 7681-49-4
15
Metformin Approved Phase 4 657-24-9 14219 4091
16
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
17 Angiotensin-Converting Enzyme Inhibitors Phase 4
18 Anticholesteremic Agents Phase 4,Phase 3
19 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Antimetabolites Phase 4,Phase 3,Phase 2
21 Calcium, Dietary Phase 4,Phase 3
22 HIV Protease Inhibitors Phase 4
23 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
24 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
25 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
26
protease inhibitors Phase 4
27 Rosuvastatin Calcium Phase 4 147098-20-2
28 Anticonvulsants Phase 4,Phase 3
29 Carbonic Anhydrase Inhibitors Phase 4
30 diuretics Phase 4,Phase 3,Phase 1,Phase 2
31 Natriuretic Agents Phase 4,Phase 1,Phase 2
32 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Adrenergic Agonists Phase 4,Phase 3,Phase 1
34 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 1
35 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 1
41 Oxytocics Phase 4,Phase 3
42 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
43 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 2
44 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1
45 Autonomic Agents Phase 4,Phase 2,Phase 1
46 Sympatholytics Phase 4,Phase 2,Phase 1
47 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
48 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
49 Antifungal Agents Phase 4,Phase 1,Phase 2
50 Immunosuppressive Agents Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 170)
id Name Status NCT ID Phase
1 Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD Unknown status NCT02008786 Phase 4
2 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4
3 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4
4 Laparascopy Versus Laparatomy in the Management of Ruptured Ectopic Pregnancy Unknown status NCT01932957 Phase 4
5 Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques Completed NCT01230892 Phase 4
6 Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty: The OCTAVIA Trial Completed NCT02577965 Phase 4
7 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
8 Clinical Effects of Eptifibatide Administration in High Risk Patients Presenting With Non-ST Segment Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Urgent Coronary Artery Bypass Graft Surgery in Short- and Long-Term Follow-up Completed NCT01863134 Phase 4
9 Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty. The OCTAVIA Trial Completed NCT01377207 Phase 4
10 Assessment of Translesional Markers and Metabolomics Completed NCT00321139 Phase 4
11 Comparison of Biomatrix Versus Gazelle in ST-Elevation Myocardial Infarction (STEMI) Completed NCT00962416 Phase 4
12 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4
13 Feasibility and Acceptability of the Combination of Propess and AN24 Monica for Outpatient Labour Induction (PRAM) Completed NCT01026948 Phase 4
14 MAPS Trial: Matrix And Platinum Science Completed NCT00396981 Phase 4
15 18F-fluoride (18F-NaF) PET for Identifying Coronary Atherosclerotic Plaques Recruiting NCT02607748 Phase 4
16 Study on the Effect of Influenza Vaccination After Heart Attack on Future Cardiovascular Prognosis Recruiting NCT02831608 Phase 4
17 Comparison of Outcomes Between the Use of Silverlon® Dressing and AQUACEL® AG Dressing Post Cardiac Device Implant Recruiting NCT02781779 Phase 4
18 Rosiglitazone and Metformin: Outcomes Trial in Nondiabetic Patients With Stable Coronary Syndromes (Romance) Pilot Study Terminated NCT00343395 Phase 4
19 The (PIVOTAL) Study Terminated NCT00444821 Phase 4
20 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
21 Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor Terminated NCT01519765 Phase 4
22 ImmeDiate Versus EArLy Invasive Approach in Non-ST-Elevation Myocardial Infarction (IDEAL NSTEMI) Withdrawn NCT00954668 Phase 4
23 Early Therapeutic Effects of Statins and Fibrates on Unstable Atherosclerotic Plaques Withdrawn NCT00243672 Phase 4
24 Non-Invasive Cardiac Screening in High Risk Patients -The GROUND Study Unknown status NCT00189111 Phase 3
25 Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients Unknown status NCT00683124 Phase 3
26 Safety and Efficacy Study of Eptifibatide in Primary Percutaneous Coronary Intervention (PCI) Completed NCT00251823 Phase 3
27 A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60) Completed NCT02145468 Phase 3
28 Impact of Clopidogrel Dose Adjustment According to Platelet Reactivity Monitoring in Patients With High on Treatment Platelet Reactivity Undergoing Percutaneous Coronary Intervention Completed NCT01505790 Phase 3
29 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
30 Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed NCT00731627 Phase 3
31 STRIPS: Shoulder Taping Reduces Injury and Pain in Stroke Completed NCT01062308 Phase 3
32 Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor Completed NCT00308711 Phase 3
33 Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Recruiting NCT02125890 Phase 3
34 Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies Recruiting NCT02907060 Phase 3
35 DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury Active, not recruiting NCT02110303 Phase 2, Phase 3
36 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Active, not recruiting NCT01371656 Phase 3
37 Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood Enrolling by invitation NCT02153515 Phase 3
38 Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure Terminated NCT00608140 Phase 3
39 Cerclage for Prevention on Preterm Birth in Women With Placenta Previa Withdrawn NCT01442207 Phase 3
40 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
41 Abdominal Aortic/Aorto-Iliac Aneurysm Endoluminal Graft Study Unknown status NCT00549354 Phase 2
42 Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis Unknown status NCT01221402 Phase 2
43 A Phase I - II Safety Study of Filgrastim (Neupogen) to Improve Left Ventricular Function After Severe Acute Myocardial Infarction Completed NCT00215124 Phase 1, Phase 2
44 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2
45 Effect of CER-001 on Atherosclerosis in Acute Coronary Syndrome (ACS) Patients - Efficacy and Safety: The CHI SQUARE Trial Completed NCT01201837 Phase 2
46 Losartan Versus Atenolol for the Treatment of Marfan Syndrome Completed NCT00593710 Phase 2
47 AMD3100 to Mobilize Stem Cells for Donation Completed NCT00075335 Phase 2
48 Losmapimod in Chronic Obstructive Pulmonary Disease Patients Stratified by Fibrinogen. Completed NCT01541852 Phase 2
49 Safety Study of Dantrolene in Subarachnoid Hemorrhage Completed NCT01024972 Phase 1, Phase 2
50 Controlled Level EVERolimus in Acute Coronary Syndromes Recruiting NCT01529554 Phase 1, Phase 2

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

MalaCards organs/tissues related to Cardiac Rupture:

39
Heart, Testes, Lung, Liver, Brain

Publications for Cardiac Rupture

Articles related to Cardiac Rupture:

(show top 50) (show all 328)
id Title Authors Year
1
Long-term outcome and risk prediction in patients suffering acute myocardial infarction complicated by post-infarction cardiac rupture. ( 27847155 )
2017
2
Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. ( 27769998 )
2016
3
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. ( 27342873 )
2016
4
Deletion of CD28 Co-stimulatory Signals Exacerbates Left Ventricular Remodeling and Increases Cardiac Rupture After Myocardial Infarction. ( 27396441 )
2016
5
Cardiac Rupture: New Features of the Old Disease. ( 26761195 )
2016
6
Cardiac rupture in takotsubo cardiomyopathy treated surgically. ( 27625696 )
2016
7
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. ( 27601324 )
2016
8
Successful surgical repair of a triple cardiac rupture using modified cohesive double patch technique. ( 27385145 )
2016
9
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. ( 27079251 )
2016
10
Blunt Cardiac Rupture: A Diagnostic Challenge. ( 28050441 )
2016
11
Blunt Traumatic Cardiac Rupture: Single-Institution Experiences over 14 Years. ( 27965920 )
2016
12
Echocardiography and Cardiac Rupture: Is Contrast Extravasation an Indication for Surgery? ( 26299914 )
2015
13
Commonalities of cardiac rupture (left ventricular free wall or ventricular septum or papillary muscle) during acute myocardial infarction secondary to atherosclerotic coronary artery disease. ( 25456862 )
2015
14
Cardiac rupture from blunt chest trauma diagnosed on transesophageal echocardiography. ( 25602449 )
2015
15
Cardiac rupture with giant left ventricular pseudoaneurysm following inferior wall myocardial infarction: A rare complication. ( 26458029 )
2015
16
Magnetic resonance imaging-based management of silent cardiac rupture. ( 25483899 )
2015
17
Cardiac rupture delayed for a week in an asymptomatic child following blunt trauma. ( 26311363 )
2015
18
Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture. ( 26511228 )
2015
19
Use of intra-aortic balloon pump support for oozing-type cardiac rupture after acute myocardial infarction. ( 26145582 )
2015
20
False negative pericardial Focused Assessment with Sonography for Trauma examination following cardiac rupture from blunt thoracic trauma: a case report. ( 26152189 )
2015
21
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. ( 25450231 )
2015
22
Cardiac rupture in a patient with Takotsubo syndrome triggered by acute myocardial infarction: two messages. ( 25499367 )
2014
23
Predictive factors of cardiac rupture in patients with ST-elevation myocardial infarction. ( 25471834 )
2014
24
Right massive haemothorax as the presentation of blunt cardiac rupture: the pitfall of coexisting pericardial laceration. ( 24218497 )
2014
25
Complete cardiac rupture associated with closed chest cardiac massage: case report and review of the literature. ( 24749147 )
2014
26
Triple cardiac rupture. ( 24876216 )
2014
27
Successful emergency department thoracotomy for traumatic cardiac rupture: effective utilization of a fret sternum saw. ( 24936846 )
2014
28
Thymosin-I^4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. ( 25015963 )
2014
29
Cardiac rupture due to blunt chest trauma: postmortem findings in two cases. ( 24887870 )
2014
30
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. ( 24130190 )
2014
31
Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years. ( 25332178 )
2014
32
Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53. ( 24749959 )
2014
33
Decreased myocardial dendritic cells is associated with impaired reparative fibrosis and development of cardiac rupture after myocardial infarction in Humans. ( 24895162 )
2014
34
Major cardiac rupture following surgical treatment for deep sternal wound infection. ( 23357524 )
2013
35
Sutureless repair for postinfarction cardiac rupture: a simple approach with a tissue-adhering patch. ( 22999512 )
2013
36
Contained cardiac rupture: an autopsy case. ( 24380225 )
2013
37
Extracorporeal life support in a severe blunt chest trauma with cardiac rupture. ( 24829813 )
2013
38
Cardiac rupture. ( 22305150 )
2013
39
Lack of Phospholipase A2 Receptor Increases Susceptibility to Cardiac Rupture after Myocardial Infarction. ( 24305469 )
2013
40
Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage. ( 23897793 )
2013
41
Intramyocardial dissecting hematoma and postinfarction cardiac rupture. ( 23167290 )
2013
42
A rare mimic of contained cardiac rupture: a diagnostic and therapeutic dilemma at a crucial time. ( 24336388 )
2013
43
Pathology findings mimicking acute myocardial infarction in a case of Takotsubo cardiomyopathy complicated by cardiac rupture. ( 22673027 )
2012
44
Multiple organ failure after a fall from heights complicated by cardiac rupture and subacute cardiac tamponade. ( 23110293 )
2012
45
Cardiac rupture in tako-tsubo cardiomyopathy with persistent ST-segment elevation. ( 22056476 )
2012
46
Cardiac rupture in a patient with an acute myocardial infarction and extensive fatty infiltration of the heart ("adipositas cordis"). ( 21719127 )
2012
47
Hypertrophic cardiomyopathy with cardiac rupture and tamponade caused by congenital disorder of glycosylation type Ia. ( 22374380 )
2012
48
Blunt cardiac rupture: a challenging diagnosis. ( 23265113 )
2012
49
Simple and quick repair of cardiac rupture due to blunt chest trauma. ( 22371946 )
2012
50
Glycogen synthase kinase-3I+ limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. ( 22086876 )
2012

Variations for Cardiac Rupture

Expression for Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for Cardiac Rupture

Pathways related to Cardiac Rupture according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.39 CXCL8 ELANE PLAT
2 11.04 CXCL8 PLAT
3 10.84 ELANE PLAT
4 9.9 CRP CXCL8

GO Terms for Cardiac Rupture

Sources for Cardiac Rupture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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