MCID: CRD016
MIFTS: 27

Cardiac Rupture malady

Summaries for Cardiac Rupture

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myocardial rupture (or heart rupture) is a laceration or tearing of the walls of the ventricles or atria... more...

MalaCards: Cardiac Rupture, also known as myocardial rupture, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Cardiac Rupture is CHKB (choline kinase beta), and among its related pathways is A-beta Plaque Formation & APP Metabolism . The compounds norepinephrine and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are behavior/neurological and muscle.

Aliases & Classifications for Cardiac Rupture

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

cardiac rupture 42 44
myocardial rupture 60


Related Diseases for Cardiac Rupture

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17GeneCards, 18GeneDecks
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Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.4CHKB, CRP, PLAT, NPPB
2acute myocardial infarction31.1MMP9, CRP, CHKB, NPPB, PLAT
3coronary artery disease30.1PLAT, CRP, CHKB, MMP9, NPPB
4endocarditis29.9PRF1
5stroke, ischemic29.9PLAT
6abdominal aortic aneurysm29.9MMP9
7aortic aneurysm29.9CRP
8systemic lupus erythematosus29.9CRP
9ischemia29.9NPPB, PLAT, CHKB
10cardiac tamponade10.4
11hemopericardium10.3
12angiosarcoma10.2
13aortic valve stenosis10.2
14septal myocardial infarction10.1
15ventricular septal defect10.1
16inferior myocardial infarction10.0
17addison's disease10.0
18infective endocarditis10.0
19myositis10.0CHKB
20sleep disorder10.0CHKB
21thromboembolism10.0PLAT
22antiphospholipid syndrome10.0PLAT
23neuroleptic malignant syndrome10.0CHKB
24brain edema10.0MMP9
25hypersensitivity reaction type ii disease10.0PRF1
26sinusitis10.0FLNC
27interstitial lung disease10.0MMP9
28carotid artery disease10.0PLAT
29cystic fibrosis10.0FLNC
30periodontitis10.0MMP9
31hemiplegia10.0PLAT
32age related macular degeneration10.0PLAT
33pelvic inflammatory disease10.0CRP
34hypertensive heart disease10.0NPPB
35periodontal disease10.0CRP
36obesity10.0CRP
37peritonitis10.0CRP
38polycystic ovary syndrome10.0CRP
39galactosemia10.0CRP
40hyperglycemia10.0CRP
41respiratory failure10.0CRP
42endophthalmitis10.0PRF1, PLAT
43hypothyroidism10.0CHKB
44middle ear cholesteatoma10.0CHKB, MMP9
45dilated cardiomyopathy10.0CHKB, NPPB
46ulcerative colitis10.0CRP
47cardiogenic shock10.0PLAT, NPPB
48pulmonary embolism10.0NPPB, PLAT
49limb-girdle muscular dystrophy10.0FLNC, CHKB
50bacteriuria10.0CRP

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to cardiac rupture

Clinical Features for Cardiac Rupture

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Drugs & Therapeutics for Cardiac Rupture

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Cardiac Rupture

Search CenterWatch for Cardiac Rupture

Genetic Tests for Cardiac Rupture

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Anatomical Context for Cardiac Rupture

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32MalaCards
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MalaCards organs/tissues related to Cardiac Rupture:

32
Heart

Animal Models for Cardiac Rupture or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cardiac Rupture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.6PLAT, MMP9, TRIM54, CHKB, PRF1, FLNC
2MP:00053697.2NPPB, FLNC, CHKB, TRIM54, MMP9, PLAT
3MP:00053856.7PLAT, PMM2, NPPB, CRP, FLNC, TRIM54

Publications for Cardiac Rupture

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Genetic Variations for Cardiac Rupture

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Expression for genes affiliated with Cardiac Rupture

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiac Rupture

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Pathways for genes affiliated with Cardiac Rupture

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52R&D Systems
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Pathways related to Cardiac Rupture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PLAT, MMP9

Compounds for genes affiliated with Cardiac Rupture

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Cardiac Rupture according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.6CHKB
2alpha tocopherol4410.5CHKB
3thallium4410.0CHKB, NPPB
4aprotinin44 1111.0NPPB, PLAT
5p0034410.0PLAT, NPPB
6enalaprilat449.9PLAT, NPPB
7quinapril44 1110.8CRP, PLAT
8ceftriaxone44 1110.8PLAT, CRP
9dobutamine44 28 1111.7NPPB, CHKB, PLAT
10ptca449.7CHKB, PLAT, NPPB
11spec-t449.7NPPB, CHKB, PLAT
12trapidil449.7MMP9, PLAT
13phosphorylcholine44 2410.7CRP, CHKB
14omapatrilat449.7MMP9, PLAT
15abciximab44 1110.6PLAT, CHKB, CRP
16clopidogrel49 44 11 2412.6CRP, PLAT, CHKB
17ramipril44 1110.6NPPB, CRP
18thyroxine44 2410.5CHKB, NPPB, PLAT
19atenolol44 28 49 11 2413.4CRP, NPPB
20tirofiban44 1110.4CRP, NPPB, PLAT
21perindopril44 49 1111.4NPPB, PLAT, CRP
22valsartan44 59 28 1112.4CRP, NPPB
23pravastatin44 49 28 11 2413.4CRP, CHKB, NPPB
24uric acid44 2410.4NPPB, CRP, CHKB
25losartan44 49 28 1112.4CRP, NPPB, PLAT
26prednisolone44 28 1111.3CHKB, CRP, NPPB
27homocysteine44 2410.3NPPB, CRP, PLAT
28telmisartan44 28 1111.2CRP, NPPB
29prostacyclin449.2PLAT, CRP, NPPB
30gabexate mesilate449.1PLAT, CRP, MMP9
31nitroglycerin44 1110.1CHKB, CRP, NPPB, PLAT
32aspirin44 49 28 2412.1CHKB, CRP, NPPB, PLAT
33nacl449.0NPPB, PRF1, CHKB
34fosinopril44 1110.0NPPB, CRP, MMP9
358-isoprostane448.9CRP, MMP9, NPPB
36pioglitazone44 49 28 1111.9MMP9, NPPB, CRP
37cyclosporin a44 28 5910.8NPPB, CHKB, MMP9, PLAT
38rosiglitazone44 49 28 11 2412.8CRP, NPPB, MMP9
39cholesterol44 28 11 2411.8CHKB, PLAT, PRF1, CRP
40fluvastatin44 49 28 1111.8MMP9, CHKB, PLAT, CRP
41simvastatin44 49 59 28 11 2413.8CRP, PLAT, MMP9, CHKB
42cyclophosphamide44 49 1110.8MMP9, CRP, NPPB
43fibrinogen448.8PLAT, MMP9, CHKB, CRP
44aspartate448.7PLAT, MMP9, CHKB, CRP
45p002448.6NPPB, CRP, MMP9, PLAT
46lactate448.5MMP9, CHKB, NPPB, CRP
47atorvastatin44 49 28 11 2412.3CHKB, NPPB, PLAT, CRP, MMP9
48creatinine448.3PLAT, MMP9, CHKB, NPPB, CRP
49testosterone44 59 11 2411.2CHKB, MMP9, CRP, NPPB
50calcium44 49 11 2410.6NPPB, MMP9, CRP, CHKB, PRF1, FLNC

GO Terms for genes affiliated with Cardiac Rupture

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16Gene Ontology
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Cellular components related to Cardiac Rupture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2PLAT, MMP9, CRP, NPPB
2extracellular regionGO:0055767.5PLAT, MMP9, PRF1, CRP, NPPB

Products for genes affiliated with Cardiac Rupture

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  • Antibodies
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Sources for Cardiac Rupture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet