Aliases & Classifications for Cardiac Rupture

MalaCards integrated aliases for Cardiac Rupture:

Name: Cardiac Rupture 49 51
Myocardial Rupture 69

Classifications:



External Ids:

UMLS 69 C0018813

Summaries for Cardiac Rupture

MalaCards based summary : Cardiac Rupture, also known as myocardial rupture, is related to acute myocardial infarction and pericardial effusion. An important gene associated with Cardiac Rupture is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Transcriptional misregulation in cancer and amb2 Integrin signaling. The drugs Lenograstim and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are cardiovascular system and muscle

Wikipedia : 72 Myocardial rupture is a laceration of the ventricles or atria of the heart, of the interatrial or... more...

Related Diseases for Cardiac Rupture

Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.7 CHKB CRP PLAT
2 pericardial effusion 29.5 CHKB CRP
3 periodontitis 29.5 CRP CXCL8 ELANE
4 myocardial infarction 10.6
5 cardiogenic shock 10.5 CRP PLAT
6 angina pectoris 10.5 CRP PLAT
7 ligneous conjunctivitis 10.4 ELANE PLAT
8 dressler's syndrome 10.4 CRP PLAT
9 intermediate coronary syndrome 10.4 CRP PLAT
10 rapidly progressive glomerulonephritis 10.4 CRP ELANE
11 dirofilariasis 10.4 CRP PLAT
12 slow-channel congenital myasthenic syndrome 10.4 CRP CXCL8
13 pyuria 10.4 CRP CXCL8
14 venous insufficiency 10.4 CRP PLAT
15 felty syndrome 10.4 CXCL8 ELANE
16 louse-borne relapsing fever 10.4 CRP CXCL8
17 cyclic neutropenia 10.4 CXCL8 ELANE
18 capillary leak syndrome 10.3 CXCL8 ELANE
19 lung abscess 10.3 CRP FLNC
20 status asthmaticus 10.3 CXCL8 ELANE
21 septic arthritis 10.3 CRP CXCL8
22 acute cystitis 10.3 CRP CXCL8
23 periodontosis 10.3 CXCL8 ELANE
24 pharyngitis 10.3 CRP CXCL8
25 wells syndrome 10.3 CRP CXCL8
26 pulmonary aspergilloma 10.3 CRP FLNC
27 acute pyelonephritis 10.3 CRP CXCL8
28 lipid pneumonia 10.3 CRP FLNC
29 anterolateral myocardial infarction 10.3 CHKB PLAT
30 perinatal necrotizing enterocolitis 10.3 CRP CXCL8
31 viral meningitis 10.3 CRP CXCL8
32 newborn respiratory distress syndrome 10.3 CXCL8 ELANE
33 pleurisy 10.3 CRP CXCL8
34 acute respiratory distress syndrome 10.3 CXCL8 ELANE
35 alpha-1-antitrypsin deficiency 10.3 CXCL8 ELANE
36 uterine anomalies 10.3 CRP CXCL8
37 bronchopulmonary dysplasia 10.2 CXCL8 ELANE
38 leptospirosis 10.2 CRP CXCL8
39 leukocyte disease 10.2 CRP ELANE
40 brucellosis 10.2 CRP CXCL8
41 pyelonephritis 10.2 CRP CXCL8
42 appendicitis 10.2 CRP CXCL8
43 adult respiratory distress syndrome 10.2 CXCL8 ELANE
44 gingivitis 10.2 CXCL8 ELANE PLAT
45 disseminated intravascular coagulation 10.2 ELANE PLAT
46 carotid stenosis 10.2 CRP CXCL8
47 pulmonary disease, chronic obstructive 10.1 CRP CXCL8 ELANE
48 chorioamnionitis 10.1 CRP CXCL8 ELANE
49 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 CRP CXCL8 ELANE
50 acute pancreatitis 10.1 CRP CXCL8 ELANE

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to Cardiac Rupture

Symptoms & Phenotypes for Cardiac Rupture

MGI Mouse Phenotypes related to Cardiac Rupture:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CRP FHL2 FLNC PLAT PMM2 PRF1
2 muscle MP:0005369 9.02 CHKB FLNC PLAT PMM2 TRIM54

Drugs & Therapeutics for Cardiac Rupture

Drugs for Cardiac Rupture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
2 Adjuvants, Immunologic Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
2 A Phase I - II Safety Study of Filgrastim (Neupogen) to Improve Left Ventricular Function After Severe Acute Myocardial Infarction Completed NCT00215124 Phase 1, Phase 2 Filgrastim
3 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
4 Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction Completed NCT02484326
5 Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy Not yet recruiting NCT02843464
6 Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy Not yet recruiting NCT03018873

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

MalaCards organs/tissues related to Cardiac Rupture:

38
Heart, Testes, Lung, Liver, Brain

Publications for Cardiac Rupture

Articles related to Cardiac Rupture:

(show top 50) (show all 342)
# Title Authors Year
1
Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction. ( 29364896 )
2018
2
Cardiac Rupture in a Young Male Cocaine User. ( 29326020 )
2018
3
Delayed Cardiac Rupture Induced by Traumatic Myocardial Infarction: Consequence of a 45-Magnum Blast Injury; A Comprehensive Case Review. ( 29379803 )
2018
4
Cardiac rupture during acute myocardial infarction diagnosed clinically. ( 29394186 )
2018
5
Association of the SYNTAX Score II with cardiac rupture in patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention. ( 29028739 )
2018
6
Long-term outcome and risk prediction in patients suffering acute myocardial infarction complicated by post-infarction cardiac rupture. ( 27847155 )
2017
7
Autotransplantation for Threatened Cardiac Rupture After Left Ventricular Repair. ( 28109380 )
2017
8
Intramyocardial contrast in a STEMI patient early direct evidence of cardiac rupture. ( 28967573 )
2017
9
Extracorporeal cardiopulmonary resuscitation for blunt cardiac rupture: A case report. ( 28801040 )
2017
10
Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials. ( 28109576 )
2017
11
Can takotsubo cardiomyopathy be diagnosed by autopsy? Report of a presumed case presenting as cardiac rupture. ( 28396614 )
2017
12
Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice. ( 29121663 )
2017
13
Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture. ( 28204966 )
2017
14
Development and validation of clinical risk score to predict the cardiac rupture in patients with STEMI. ( 28132793 )
2017
15
Late Cardiac Rupture after Amplatzer Septal Occluder Implantation. ( 28100979 )
2016
16
Cardiac rupture in takotsubo cardiomyopathy treated surgically. ( 27625696 )
2016
17
Blunt Cardiac Rupture: A Diagnostic Challenge. ( 28050441 )
2016
18
Cardiac Rupture: New Features of the Old Disease. ( 26761195 )
2016
19
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. ( 27601324 )
2016
20
Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. ( 27769998 )
2016
21
Deletion of CD28 Co-stimulatory Signals Exacerbates Left Ventricular Remodeling and Increases Cardiac Rupture After Myocardial Infarction. ( 27396441 )
2016
22
Blunt Traumatic Cardiac Rupture: Single-Institution Experiences over 14 Years. ( 27965920 )
2016
23
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. ( 27342873 )
2016
24
Successful surgical repair of a triple cardiac rupture using modified cohesive double patch technique. ( 27385145 )
2016
25
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. ( 27079251 )
2016
26
Cardiac rupture from blunt chest trauma diagnosed on transesophageal echocardiography. ( 25602449 )
2015
27
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. ( 25450231 )
2015
28
Use of intra-aortic balloon pump support for oozing-type cardiac rupture after acute myocardial infarction. ( 26145582 )
2015
29
Cardiac rupture with giant left ventricular pseudoaneurysm following inferior wall myocardial infarction: A rare complication. ( 26458029 )
2015
30
Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture. ( 26511228 )
2015
31
Cardiac rupture delayed for a week in an asymptomatic child following blunt trauma. ( 26311363 )
2015
32
Commonalities of cardiac rupture (left ventricular free wall or ventricular septum or papillary muscle) during acute myocardial infarction secondary to atherosclerotic coronary artery disease. ( 25456862 )
2015
33
Echocardiography and Cardiac Rupture: Is Contrast Extravasation an Indication for Surgery? ( 26299914 )
2015
34
False negative pericardial Focused Assessment with Sonography for Trauma examination following cardiac rupture from blunt thoracic trauma: a case report. ( 26152189 )
2015
35
Magnetic resonance imaging-based management of silent cardiac rupture. ( 25483899 )
2015
36
Right massive haemothorax as the presentation of blunt cardiac rupture: the pitfall of coexisting pericardial laceration. ( 24218497 )
2014
37
Complete cardiac rupture associated with closed chest cardiac massage: case report and review of the literature. ( 24749147 )
2014
38
Triple cardiac rupture. ( 24876216 )
2014
39
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. ( 24130190 )
2014
40
Cardiac rupture in a patient with Takotsubo syndrome triggered by acute myocardial infarction: two messages. ( 25499367 )
2014
41
Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years. ( 25332178 )
2014
42
Successful emergency department thoracotomy for traumatic cardiac rupture: effective utilization of a fret sternum saw. ( 24936846 )
2014
43
Decreased myocardial dendritic cells is associated with impaired reparative fibrosis and development of cardiac rupture after myocardial infarction in Humans. ( 24895162 )
2014
44
Predictive factors of cardiac rupture in patients with ST-elevation myocardial infarction. ( 25471834 )
2014
45
Thymosin-I^4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. ( 25015963 )
2014
46
Cardiac rupture due to blunt chest trauma: postmortem findings in two cases. ( 24887870 )
2014
47
Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53. ( 24749959 )
2014
48
Extracorporeal life support in a severe blunt chest trauma with cardiac rupture. ( 24829813 )
2013
49
Major cardiac rupture following surgical treatment for deep sternal wound infection. ( 23357524 )
2013
50
Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage. ( 23897793 )
2013

Variations for Cardiac Rupture

Expression for Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for Cardiac Rupture

Pathways related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CXCL8 ELANE PLAT
2 10.84 ELANE PLAT
3 9.9 CRP CXCL8

GO Terms for Cardiac Rupture

Cellular components related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 FHL2 FLNC TRIM54

Sources for Cardiac Rupture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....