Cardiac Rupture malady

Wikipedia: Myocardial rupture (or heart rupture) is a laceration or tearing of the walls of the ventricles or atria...⁴⁴ more...

MalaCards: Cardiac Rupture, also known as myocardial rupture, is related to acute myocardial infarction and myocardial infarction. An important gene associated with Cardiac Rupture is CHKB (choline kinase beta), and among its related pathways are Cell adhesion_ECM remodeling and Cell adhesion ECM remodeling. The compounds p005 and thallium have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related mouse phenotype muscle.

cardiac rupture 30 32 myocardial rupture 43

Diseases related to cardiac rupture by text searches and GeneDecks gene sharing:

(show top 50)    (show all 187)

id	Related Disease	Score	Top Affiliating Genes
1	acute myocardial infarction	28.6	MMP9, CHKB, NPPB, PLAT, CRP
2	myocardial infarction	28.6	NPPB, CRP, CHKB, PLAT, MMP9
3	aortic valve stenosis	26.6	PLAT, NPPB, MMP9, CRP
4	achenbach syndrome	13.0	CHKB, PLAT
5	neuroleptic malignant syndrome	13.0	CHKB, NPPB
6	inferior myocardial infarction	13.0	PLAT, NPPB
7	catecholaminergic polymorphic ventricular tachycardia	12.9	CHKB, NPPB
8	viral pneumonia	12.9	CRP, CHKB
9	polyarteritis nodosa	12.9	CHKB, CRP
10	meningoencephalitis	12.9	CHKB, CRP
11	diabetic ketoacidosis	12.9	CRP, CHKB
12	thrombophlebitis	12.8	PLAT, CRP
13	coronary restenosis	12.8	PLAT, CRP
14	systolic heart failure	12.8	NPPB, CRP
15	carotid artery disease	12.8	PLAT, CRP
16	portal vein thrombosis	12.8	PLAT, CRP
17	coronary stenosis	12.8	CRP, NPPB
18	cryoglobulinemia	12.8	PLAT, NPPB
19	pericarditis	12.8	NPPB, CRP
20	venous insufficiency	12.8	PLAT, CRP
21	autonomic dysfunction	12.8	CRP, NPPB
22	retinal vein occlusion	12.8	CRP, PLAT
23	peripheral vascular disease	12.7	CRP, PLAT
24	arterial occlusive disease	12.7	PLAT, CRP
25	sleep disorder	12.7	NPPB, CRP
26	status asthmaticus	12.7	MMP9, CHKB
27	primary pulmonary hypertension	12.7	NPPB, PLAT
28	actinic cheilitis	12.7	CHKB, MMP9
29	fabry disease	12.7	CRP, NPPB
30	cheilitis	12.7	MMP9, CHKB
31	systemic lupus erythematosus, association with	12.7	CRP, PLAT
32	deep vein thrombosis	12.7	PLAT, CRP
33	toxic epidermal necrolysis	12.7	CHKB, MMP9
34	hellp syndrome	12.7	CRP, PLAT
35	hypertensive heart disease	12.6	MMP9, NPPB
36	diastolic heart failure	12.6	NPPB, MMP9
37	subacute sclerosing panencephalitis	12.6	CHKB, MMP9
38	chronic venous leg ulcers	12.6	MMP9, PLAT
39	middle ear cholesteatoma	12.6	MMP9, CHKB
40	pulmonary edema	12.6	CRP, NPPB
41	back pain	12.6	PLAT, MMP9
42	end stage renal failure	12.6	CRP, NPPB
43	parotitis	12.5	CRP, MMP9
44	diabetic foot ulcers	12.5	MMP9, CRP
45	cerebral amyloid angiopathy	12.5	MMP9, PLAT
46	septic arthritis	12.5	MMP9, CRP
47	diabetes insipidus	12.5	CRP, PLAT
48	acute pyelonephritis	12.5	CRP, MMP9
49	klebsiella	12.5	PLAT, MMP9
50	alcoholic hepatitis	12.5	PLAT, CRP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cardiac rupture:

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MGI Mouse Phenotypes related to cardiac rupture:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	8.2	CHKB, MMP9, PLAT, NPPB

Articles related to cardiac rupture:

id	Title	Authors	Year	Affiliating Genes
1	Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture. (16723786)	Kameda K.... Okumura K.	2006	MMP9
2	Postinfarction cardiac rupture despite immediate reperfusion therapy in a patient with severe aortic valve stenosis. (16440151)	Tanaka M.... Nonogi H.	2006	PLAT
3	Brain natriuretic peptide and cardiac rupture after acute myocardial infarction. (11310490)	Arakawa N.... Hiramori K.	2001	NPPB
4	C-reactive protein as a predictor of infarct expansion and cardiac rupture after a first Q-wave acute myocardial infarction. (9264482)	Anzai T.... Ogawa S.	1997	CRP
5	C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction. (8615301)	Ueda S.... Shimada K.	1996	CRP
6	A rare case of coronary artery perforation by a PTCA guide wire complicating with postinfarction cardiac rupture after thrombolytic therapy (7594850)	Ogino H.... Sakai T.	1995	PLAT

Genes related to cardiac rupture according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CHKB	choline kinase beta	11.0
2	PLAT	plasminogen activator, tissue	11.0	Publications
3	CRP	C-reactive protein, pentraxin-related	11.0	Publications
4	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
5	NPPB	natriuretic peptide B	11.0	Publications

Pathways related to cardiac rupture according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_ECM remodeling41	9.1	MMP9, PLAT
2	Cell adhesion ECM remodeling10	8.8	MMP9, PLAT

Compounds related to cardiac rupture according to GeneDecks:

(show top 50)    (show all 79)

id	Compound	Score	Top Affiliating Genes
1	p00532	10.3	CRP
2	thallium32	9.9	NPPB, CHKB
3	enalaprilat32	9.7	NPPB, PLAT
4	quinapril32 9 9	11.6	CRP, PLAT
5	ceftriaxone32 9 9	11.6	PLAT, CRP
6	trapidil32	9.5	PLAT, MMP9
7	ramipril32 9 9	11.5	CRP, NPPB
8	phosphorylcholine32 18	10.5	CRP, CHKB
9	omapatrilat32	9.4	MMP9, PLAT
10	dobutamine32 9 9	11.4	CHKB, NPPB, PLAT
11	ptca32	9.4	CHKB, NPPB, PLAT
12	spec-t32	9.4	PLAT, CHKB, NPPB
13	valsartan32 42 9 9	12.3	CRP, NPPB
14	abciximab32 9 9	11.3	CRP, CHKB, PLAT
15	pravastatin32 34 9 18 9	13.3	NPPB, CRP, CHKB
16	thyroxine32 18	10.3	CHKB, NPPB, PLAT
17	tirofiban32 9 9	11.2	NPPB, PLAT, CRP
18	uric acid32 18	10.2	CHKB, CRP, NPPB
19	perindopril32 34 9 9	12.2	NPPB, PLAT, CRP
20	telmisartan32 9 9	11.2	CRP, NPPB
21	losartan32 34 9 9	12.2	CRP, NPPB, PLAT
22	prednisolone32 9 9	11.2	CHKB, CRP, NPPB
23	p00332	9.2	NPPB, CRP, PLAT
24	homocysteine32 18	10.1	NPPB, PLAT, CRP
25	prostacyclin32	9.0	NPPB, CRP, PLAT
26	aprotinin32 9 9	11.0	MMP9, PLAT, NPPB
27	fosinopril32 9 9	11.0	NPPB, CRP, MMP9
28	gabexate mesilate32	9.0	PLAT, CRP, MMP9
29	alpha tocopherol32	8.9	MMP9, CHKB, CRP
30	8-isoprostane32	8.9	NPPB, MMP9, CRP
31	pioglitazone32 9 9	10.9	NPPB, MMP9, CRP
32	rosiglitazone32 9 18 9	11.8	NPPB, MMP9, CRP
33	cyclophosphamide32 34 9 9	11.8	CRP, MMP9, NPPB
34	aspirin32 34 18	10.8	NPPB, CHKB, PLAT, CRP
35	methotrexate32 34 42 9 9	12.8	CRP, MMP9, CHKB
36	chloramphenicol32 9 9	10.6	CRP, MMP9, PLAT
37	n acetylcysteine32	8.6	MMP9, CRP, CHKB
38	cyclosporin a32 42	9.6	NPPB, PLAT, MMP9, CHKB
39	fluvastatin32 34 9 9	11.5	MMP9, CRP, PLAT, CHKB
40	simvastatin32 34 42 9 18 9	13.5	MMP9, CHKB, CRP, PLAT
41	fibrinogen32	8.5	CHKB, MMP9, PLAT, CRP
42	norepinephrine32 9 18 9	11.5	MMP9, NPPB, CRP, CHKB
43	p00232	8.4	NPPB, PLAT, CRP, MMP9
44	lactate32	8.4	CHKB, MMP9, CRP, NPPB
45	aspartate32	8.4	CHKB, CRP, PLAT, MMP9
46	epinephrine32 9 18 9	11.4	MMP9, CHKB, NPPB
47	testosterone32 9 18 9	11.4	MMP9, CRP, CHKB, NPPB
48	vegf32	8.3	CRP, MMP9, CHKB, NPPB
49	atorvastatin32 34 9 18 9	12.0	NPPB, PLAT, CRP, MMP9, CHKB
50	creatinine32	8.0	NPPB, PLAT, CRP, MMP9, CHKB

Cellular components related to cardiac rupture according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	8.0	MMP9, CRP, PLAT, NPPB
2	extracellular space	GO:005615	7.7	MMP9, CRP, PLAT, NPPB

Biological processes related to cardiac rupture according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	response to peptide hormone stimulus	GO:043434	9.4	PLAT, NPPB
2	response to hypoxia	GO:001666	7.7	MMP9, CRP, PLAT, NPPB