MCID: CRD016
MIFTS: 41

Cardiac Rupture malady

Rare diseases category
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Summaries for Cardiac Rupture

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Wikipedia:65 Myocardial rupture (or heart rupture) is a laceration or tearing of the walls of the ventricles or atria... more...

MalaCards based summary: Cardiac Rupture, also known as myocardial rupture, is related to myocardial infarction and pericardial effusion. An important gene associated with Cardiac Rupture is CHKB (choline kinase beta), and among its related pathways are Selenium Pathway and Cell adhesion ECM remodeling. The compounds thallium and enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are cellular and behavior/neurological.

Aliases & Classifications for Cardiac Rupture

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
See all sources

Cardiac Rupture, Aliases & Descriptions:

Name: Cardiac Rupture 42 44
 
Myocardial Rupture 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Cardiac Rupture

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Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.1PLAT, CHKB, CRP, NPPB
2pericardial effusion30.7CHKB
3acute myocardial infarction30.5MMP9, NPPB, CRP, PLAT, CHKB
4ischemia30.0NPPB, PLAT, CHKB
5neuroleptic malignant syndrome10.5CHKB
6hemopericardium10.4
7cholesteatoma10.4MMP9
8aneurysm10.3
9endophthalmitis10.3PLAT, PRF1
10cardiac tamponade10.3
11limb-girdle muscular dystrophy10.3CHKB, FLNC
12middle ear cholesteatoma10.3CHKB, MMP9
13aortic aneurysm10.3CRP
14bacteriuria10.3CRP
15cardiogenic shock10.2NPPB, PLAT
16angiosarcoma10.2
17aortic valve stenosis10.2
18synovitis10.2CRP
19muscular dystrophy10.2CHKB, FLNC
20pulmonary embolism10.2NPPB, PLAT
21skin disease10.2MMP9, PRF1
22artery disease10.1
23ventricular septal defect10.1
24myocarditis10.1PRF1, CHKB, NPPB
25congestive heart failure10.1CHKB, NPPB
26hyperhomocysteinemia10.1PLAT, CRP
27carotid stenosis10.0CRP, MMP9
28noonan syndrome10.0NPPB, CHKB, FLNC
29chronic obstructive pulmonary disease10.0MMP9, CRP
30systemic lupus erythematosus10.0
31factor xiii deficiency10.0
32tetralogy of fallot10.0
33hypertrophic cardiomyopathy10.0
34cerebritis10.0
35congenital disorder of glycosylation10.0
36lung cancer10.0
37lupus erythematosus10.0
38mediastinitis10.0
39pericarditis10.0
40thromboembolism10.0
41periodontal disease9.9CRP, MMP9
42myopathy9.9CHKB, CRP, FLNC
43stroke, ischemic9.9MMP9, CRP, PLAT
44amyloidosis9.9CRP, NPPB
45vascular disease9.9CRP, MMP9, PLAT
46meningitis9.9CRP, MMP9, PRF1
47asthma9.9CHKB, MMP9, FLNC
48septic shock9.8NPPB, CRP
49melanoma9.8MMP9, CHKB, PRF1, FLNC
50cerebrovascular disease9.8PLAT, NPPB, CRP

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to cardiac rupture

Symptoms for Cardiac Rupture

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Drugs & Therapeutics for Cardiac Rupture

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Drug clinical trials:

Search ClinicalTrials for Cardiac Rupture

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

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Anatomical Context for Cardiac Rupture

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MalaCards organs/tissues related to Cardiac Rupture:

32
Heart, Testes, Brain, Liver, Lung

Animal Models for Cardiac Rupture or affiliated genes

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MGI Mouse Phenotypes related to Cardiac Rupture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.0TRIM54, PLAT, PRF1, MMP9, PMM2
2MP:00053867.6FLNC, MMP9, CHKB, PRF1, PLAT, TRIM54
3MP:00053697.5FLNC, MMP9, CHKB, PLAT, NPPB, TRIM54
4MP:00107687.2PMM2, FLNC, MMP9, PRF1, PLAT, TRIM54
5MP:00053856.8TRIM54, PMM2, FLNC, MMP9, PLAT, CRP

Publications for Cardiac Rupture

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Articles related to Cardiac Rupture:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
Thymosin-I^4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. (25015963)
2014
2
Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years. (25332178)
2014
3
Cardiac rupture. (22305150)
2013
4
Extracorporeal life support in a severe blunt chest trauma with cardiac rupture. (24829813)
2013
5
Sutureless repair for postinfarction cardiac rupture: a simple approach with a tissue-adhering patch. (22999512)
2013
6
Blunt cardiac rupture in the setting of previous sternotomy. (22579894)
2012
7
Acute myocardial infarction and swinging heart: not always a cardiac rupture--haemopericardium due to infiltrative lung cancer. (22645189)
2012
8
Administration of intrapericardial tissue adhesive after cardiac rupture and cardiac tamponade. (19201492)
2011
9
Survival of blunt cardiac rupture after asystolic arrest: a case report. (19359944)
2009
10
Cardiac rupture or pericardial effusion? (17692412)
2008
11
Five cases of blunt traumatic cardiac rupture: success and failure in surgical management. (17554994)
2007
12
Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice. (16533502)
2006
13
Cardiac rupture after minor blunt chest injury as a result of occult recent myocardial infarction. (16129541)
2005
14
Usefulness of delayed enhancement magnetic resonance imaging for detecting cardiac rupture caused by small myocardial infarction in a case of cardiac tamponade. (16308508)
2005
15
Effect of reperfusion therapy on cardiac rupture after myocardial infarction in Japanese. (15118282)
2004
16
Three-dimensional echocardiography of post-myocardial infarction cardiac rupture. (15053793)
2004
17
Cardiac rupture in acute myocardial infarction: a reassessment. (11953501)
2002
18
Endoventricular circular patch plasty with aortic valve replacement for post-infarction cardiac rupture complicated with aortic valve stenosis: case report. (12381096)
2002
19
Renin-angiotensin system and cardiac rupture after myocardial infarction. (12390941)
2002
20
Primary coronary angioplasty in acute myocardial infarction: is it possible to prevent postinfarction cardiac rupture? (10929740)
2000
21
Blunt cardiac rupture: the utility of emergency department ultrasound. (10355395)
1999
22
Diagnosis and treatment of blunt cardiac rupture. (9090319)
1997
23
Cardiac rupture with dobutamine stress echocardiography. (9440077)
1997
24
Cardiac rupture due to blunt trauma. (9225900)
1997
25
C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction. (8615301)
1996
26
A rare case of coronary artery perforation by a PTCA guide wire complicating with postinfarction cardiac rupture after thrombolytic therapy]. (7594850)
1995
27
Treatment of acute cardiac rupture by autologous pericardial patch without infarctectomy. (8054736)
1994
28
Clinico-pathological study of the role of infarct expansion in patients with cardiac rupture following acute myocardial infarction. (7966995)
1994
29
Survival after postinfarction cardiac rupture in severe aortic valve stenosis. (8174576)
1994
30
Cardiac rupture, a clinically predictable complication of acute myocardial infarction: report of 70 cases with clinicopathologic correlations. (8354804)
1993
31
Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium. (8431074)
1993
32
A partial defect in technetium-99m pyrophosphate image suggesting cardiac rupture following acute myocardial infarction. (1533369)
1992
33
The use of echocardiography in the emergency management of nonpenetrating traumatic cardiac rupture. (1952316)
1991
34
Cardiac rupture due to severe fatty infiltration in the right ventricular wall. (1919483)
1991
35
Cardiac rupture secondary to blunt trauma: a rapidly diagnosable entity with two-dimensional echocardiography. (1854076)
1991
36
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
37
Sutureless repair of postinfarction cardiac rupture. (2980052)
1988
38
Pseudoaneurysm--a treatable form of cardiac rupture. (3202017)
1988
39
Cardiac rupture secondary to isolated midcircumflex artery obstruction. (3480457)
1987
40
Cardiac rupture, abdominal aneurysmal rupture and dissecting aortic rupture: a preventive trio. (3962881)
1986
41
Association of eosinophils with cardiac rupture. (3997134)
1985
42
Surgical repair of acute postinfarction cardiac rupture. (3979071)
1985
43
Acute cardiac rupture and tamponade: angiographic appearance. (3969907)
1985
44
Vasopressors and cardiac rupture. (7223670)
1981
45
Anatomic, clinical, and therapeutic features of acute cardiac rupture. Successful surgical management fourteen hours after myocardial infarction. (661371)
1978
46
Postinfarction cardiac rupture. (5285998)
1971
47
Sudden death due to cardiac rupture in myocardial ischemia and infarction. Causes, mechanism, and possible prevention. (5252737)
1969
48
FACTORS IN CARDIAC RUPTURE. (14055888)
1963
49
The influence of anticoagulant therapy on the occurrence of cardiac rupture and hemopericardium following heart infarction. I. A study of 89 cases of hemopericardium (81 of them cardiac ruptures). (13545172)
1958
50
Spontaneous Cardiac Rupture. (20322160)
1941

Variations for Cardiac Rupture

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Expression for genes affiliated with Cardiac Rupture

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Expression patterns in normal tissues for genes affiliated with Cardiac Rupture

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Pathways for genes affiliated with Cardiac Rupture

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Pathways related to Cardiac Rupture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway37
9.5CRP, PLAT
2
Show member pathways
9.3PLAT, MMP9
39.3MMP9, PLAT
49.3PLAT, MMP9
59.3PLAT, MMP9

Compounds for genes affiliated with Cardiac Rupture

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Compounds related to Cardiac Rupture according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1thallium4410.0CHKB, NPPB
2enalaprilat449.8PLAT, NPPB
3quinapril44 50 1111.7PLAT, CRP
4dobutamine44 28 50 1112.7NPPB, CHKB, PLAT
5ptca449.7PLAT, CHKB, NPPB
6ceftriaxone44 1110.7CRP, PLAT
7spec-t449.7PLAT, CHKB, NPPB
8trapidil449.7PLAT, MMP9
9abciximab44 1110.6CHKB, PLAT, CRP
10omapatrilat449.6MMP9, PLAT
11clopidogrel44 50 24 1112.6CRP, PLAT, CHKB
12thyroxine44 2410.5NPPB, PLAT, CHKB
13tirofiban44 1110.4PLAT, CRP, NPPB
14perindopril44 50 1111.4PLAT, CRP, NPPB
15p005449.4CRP, PLAT, NPPB
16uric acid44 2410.4CRP, NPPB, CHKB
17pravastatin44 50 28 24 1113.4CHKB, CRP, NPPB
18losartan44 50 28 1112.4PLAT, CRP, NPPB
19ramipril44 1110.3NPPB, CRP
20valsartan44 61 28 1112.3CRP, NPPB
21prednisolone44 28 1111.3CRP, NPPB, CHKB
22p003449.3NPPB, CRP, PLAT
23homocysteine44 2410.3PLAT, CRP, NPPB
24phosphorylcholine44 2410.2CHKB, CRP
25aprotinin44 1110.2MMP9, PLAT, NPPB
26nacl449.2PRF1, CHKB, NPPB
27gabexate mesilate449.1MMP9, PLAT, CRP
28nitroglycerin44 1110.1NPPB, CRP, PLAT, CHKB
29prostacyclin449.1NPPB, PLAT, CRP
30aspirin44 50 28 2412.1CRP, NPPB, PLAT, CHKB
31alpha tocopherol449.1MMP9, CHKB, CRP
32fosinopril44 1110.0NPPB, CRP, MMP9
338-isoprostane448.9NPPB, CRP, MMP9
34pioglitazone28 44 50 1111.9CRP, NPPB, MMP9
35cholesterol44 28 24 1111.9PRF1, CRP, PLAT, CHKB
36cyclosporin a44 28 6110.8NPPB, PLAT, CHKB, MMP9
37fluvastatin44 50 28 1111.8PLAT, MMP9, CRP, CHKB
38simvastatin44 50 61 28 24 1113.8PLAT, CHKB, CRP, MMP9
39rosiglitazone28 44 50 24 1112.8NPPB, CRP, MMP9
40fibrinogen448.8MMP9, CHKB, CRP, PLAT
41cyclophosphamide44 50 1110.7MMP9, CRP, NPPB
42aspartate448.7MMP9, CHKB, CRP, PLAT
43p002448.6MMP9, PLAT, CRP, NPPB
44norepinephrine44 24 1110.6CHKB, MMP9, CRP, NPPB
45cycloheximide448.6CRP, PLAT, PRF1, MMP9
46lactate448.5CHKB, CRP, NPPB, MMP9
47testosterone44 61 24 1111.3MMP9, CRP, NPPB, CHKB
48atorvastatin44 50 28 24 1112.3CRP, CHKB, MMP9, PLAT, NPPB
49creatinine448.3CRP, PLAT, CHKB, MMP9, NPPB
50calcium44 50 24 1110.7PRF1, CHKB, MMP9, FLNC, NPPB, CRP

GO Terms for genes affiliated with Cardiac Rupture

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Cellular components related to Cardiac Rupture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2NPPB, CRP, PLAT, MMP9
2extracellular regionGO:0055767.5NPPB, CRP, PLAT, PRF1, MMP9

Products for genes affiliated with Cardiac Rupture

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  • Antibodies
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Sources for Cardiac Rupture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet