MCID: CRD016
MIFTS: 41

Cardiac Rupture malady

Rare diseases category

Summaries for Cardiac Rupture

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66Wikipedia, 34MalaCards
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Wikipedia:66 Myocardial rupture (or heart rupture) is a laceration or tearing of the walls of the ventricles or atria... more...

MalaCards: Cardiac Rupture, also known as myocardial rupture, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Cardiac Rupture is CHKB (choline kinase beta), and among its related pathways are Selenium Pathway and Cell adhesion ECM remodeling. The compounds thallium and enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are cellular and behavior/neurological.

Aliases & Classifications for Cardiac Rupture

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Sources:
44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

cardiac rupture 44 46
myocardial rupture 63


Related Diseases for Cardiac Rupture

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18GeneCards, 19GeneDecks
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Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.4PLAT, CHKB, CRP, NPPB
2acute myocardial infarction31.0MMP9, NPPB, CRP, PLAT, CHKB
3pericardial effusion30.1CHKB
4coronary artery disease30.1PLAT, CRP, CHKB, NPPB
5ischemia29.9NPPB, PLAT, CHKB
6hemopericardium10.4
7aneurysm10.3
8cardiac tamponade10.3
9angiosarcoma10.2
10aortic valve stenosis10.2
11artery disease10.1
12ventricular septal defect10.1
13neuroleptic malignant syndrome10.1CHKB
14cholesteatoma10.1MMP9
15endophthalmitis10.1PLAT, PRF1
16limb-girdle muscular dystrophy10.1CHKB, FLNC
17middle ear cholesteatoma10.1CHKB, MMP9
18aortic aneurysm10.1CRP
19bacteriuria10.1CRP
20cardiogenic shock10.0NPPB, PLAT
21synovitis10.0CRP
22muscular dystrophy10.0CHKB, FLNC
23pulmonary embolism10.0NPPB, PLAT
24skin disease10.0MMP9, PRF1
25myocarditis10.0PRF1, CHKB, NPPB
26congestive heart failure10.0CHKB, NPPB
27hyperhomocysteinemia10.0PLAT, CRP
28carotid stenosis10.0CRP, MMP9
29noonan syndrome10.0NPPB, CHKB, FLNC
30pulmonary disease, chronic obstructive10.0MMP9, CRP
31periodontal disease10.0CRP, MMP9
32myopathy10.0CHKB, CRP, FLNC
33stroke, ischemic10.0MMP9, CRP, PLAT
34amyloidosis10.0CRP, NPPB
35vascular disease10.0CRP, MMP9, PLAT
36meningitis10.0CRP, MMP9, PRF1
37asthma10.0CHKB, MMP9, FLNC
38factor xiii deficiency10.0
39tetralogy of fallot10.0
40hypertrophic cardiomyopathy10.0
41cerebritis10.0
42systemic lupus erythematosus10.0
43congenital disorder of glycosylation10.0
44lung cancer10.0
45lupus erythematosus10.0
46mediastinitis10.0
47pericarditis10.0
48thromboembolism10.0
49septic shock10.0NPPB, CRP
50melanoma10.0MMP9, CHKB, PRF1, FLNC

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to cardiac rupture

Symptoms for Cardiac Rupture

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Drugs & Therapeutics for Cardiac Rupture

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cardiac Rupture

Drug clinical trials:

Search ClinicalTrials for Cardiac Rupture

Search NIH Clinical Center for Cardiac Rupture

Search CenterWatch for Cardiac Rupture

Genetic Tests for Cardiac Rupture

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Anatomical Context for Cardiac Rupture

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34MalaCards
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MalaCards organs/tissues related to Cardiac Rupture:

34
Heart, Testes, Brain, Liver, Lung

Animal Models for Cardiac Rupture or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Cardiac Rupture:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.0TRIM54, PLAT, PRF1, MMP9, PMM2
2MP:00053867.6FLNC, MMP9, CHKB, PRF1, PLAT, TRIM54
3MP:00053697.5FLNC, MMP9, CHKB, PLAT, NPPB, TRIM54
4MP:00107687.2PMM2, FLNC, MMP9, PRF1, PLAT, TRIM54
5MP:00053856.8TRIM54, PMM2, FLNC, MMP9, PLAT, CRP

Publications for Cardiac Rupture

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53PubMed
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Articles related to Cardiac Rupture:

(show top 50)    (show all 296)
idTitleAuthorsYear
1
Cardiac rupture. (22305150)
2013
2
Sutureless repair for postinfarction cardiac rupture: a simple approach with a tissue-adhering patch. (22999512)
2013
3
Blunt cardiac rupture in the setting of previous sternotomy. (22579894)
2012
4
Acute myocardial infarction and swinging heart: not always a cardiac rupture--haemopericardium due to infiltrative lung cancer. (22645189)
2012
5
Administration of intrapericardial tissue adhesive after cardiac rupture and cardiac tamponade. (19201492)
2011
6
Survival of blunt cardiac rupture after asystolic arrest: a case report. (19359944)
2009
7
Cardiac rupture or pericardial effusion? (17692412)
2008
8
Five cases of blunt traumatic cardiac rupture: success and failure in surgical management. (17554994)
2007
9
Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice. (16533502)
2006
10
Cardiac rupture after minor blunt chest injury as a result of occult recent myocardial infarction. (16129541)
2005
11
Usefulness of delayed enhancement magnetic resonance imaging for detecting cardiac rupture caused by small myocardial infarction in a case of cardiac tamponade. (16308508)
2005
12
Effect of reperfusion therapy on cardiac rupture after myocardial infarction in Japanese. (15118282)
2004
13
Three-dimensional echocardiography of post-myocardial infarction cardiac rupture. (15053793)
2004
14
Cardiac rupture in acute myocardial infarction: a reassessment. (11953501)
2002
15
Endoventricular circular patch plasty with aortic valve replacement for post-infarction cardiac rupture complicated with aortic valve stenosis: case report. (12381096)
2002
16
Renin-angiotensin system and cardiac rupture after myocardial infarction. (12390941)
2002
17
Primary coronary angioplasty in acute myocardial infarction: is it possible to prevent postinfarction cardiac rupture? (10929740)
2000
18
Blunt cardiac rupture: the utility of emergency department ultrasound. (10355395)
1999
19
Diagnosis and treatment of blunt cardiac rupture. (9090319)
1997
20
Cardiac rupture with dobutamine stress echocardiography. (9440077)
1997
21
Cardiac rupture due to blunt trauma. (9225900)
1997
22
C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction. (8615301)
1996
23
A rare case of coronary artery perforation by a PTCA guide wire complicating with postinfarction cardiac rupture after thrombolytic therapy]. (7594850)
1995
24
Treatment of acute cardiac rupture by autologous pericardial patch without infarctectomy. (8054736)
1994
25
Clinico-pathological study of the role of infarct expansion in patients with cardiac rupture following acute myocardial infarction. (7966995)
1994
26
Survival after postinfarction cardiac rupture in severe aortic valve stenosis. (8174576)
1994
27
Cardiac rupture, a clinically predictable complication of acute myocardial infarction: report of 70 cases with clinicopathologic correlations. (8354804)
1993
28
Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium. (8431074)
1993
29
Intramyocardial dissecting hematoma: an unusual form of subacute cardiac rupture. (8286867)
1993
30
A partial defect in technetium-99m pyrophosphate image suggesting cardiac rupture following acute myocardial infarction. (1533369)
1992
31
The use of echocardiography in the emergency management of nonpenetrating traumatic cardiac rupture. (1952316)
1991
32
Cardiac rupture due to severe fatty infiltration in the right ventricular wall. (1919483)
1991
33
Cardiac rupture secondary to blunt trauma: a rapidly diagnosable entity with two-dimensional echocardiography. (1854076)
1991
34
Delayed cardiac rupture due to blunt chest trauma. (1882780)
1991
35
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
36
Sutureless repair of postinfarction cardiac rupture. (2980052)
1988
37
Pseudoaneurysm--a treatable form of cardiac rupture. (3202017)
1988
38
Left ventricular pseudopseudoaneurysm: angiographic features and surgical treatment of impending cardiac rupture. (3414499)
1988
39
Cardiac rupture secondary to isolated midcircumflex artery obstruction. (3480457)
1987
40
Cardiac rupture, abdominal aneurysmal rupture and dissecting aortic rupture: a preventive trio. (3962881)
1986
41
Association of eosinophils with cardiac rupture. (3997134)
1985
42
Surgical repair of acute postinfarction cardiac rupture. (3979071)
1985
43
Acute cardiac rupture and tamponade: angiographic appearance. (3969907)
1985
44
Vasopressors and cardiac rupture. (7223670)
1981
45
Anatomic, clinical, and therapeutic features of acute cardiac rupture. Successful surgical management fourteen hours after myocardial infarction. (661371)
1978
46
Postinfarction cardiac rupture. (5285998)
1971
47
Sudden death due to cardiac rupture in myocardial ischemia and infarction. Causes, mechanism, and possible prevention. (5252737)
1969
48
FACTORS IN CARDIAC RUPTURE. (14055888)
1963
49
The influence of anticoagulant therapy on the occurrence of cardiac rupture and hemopericardium following heart infarction. I. A study of 89 cases of hemopericardium (81 of them cardiac ruptures). (13545172)
1958
50
Spontaneous Cardiac Rupture. (20322160)
1941

Variations for Cardiac Rupture

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Expression for genes affiliated with Cardiac Rupture

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for genes affiliated with Cardiac Rupture

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 13EMD Millipore, 55R&D Systems
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Pathways related to Cardiac Rupture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway39
9.5CRP, PLAT
2
Show member pathways
9.3MMP9, PLAT
39.3MMP9, PLAT
49.3MMP9, PLAT
59.3PLAT, MMP9

Compounds for genes affiliated with Cardiac Rupture

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Cardiac Rupture according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1thallium4610.0NPPB, CHKB
2enalaprilat469.8PLAT, NPPB
3dobutamine46 30 52 1212.7NPPB, PLAT, CHKB
4quinapril46 52 1211.7PLAT, CRP
5ptca469.7NPPB, PLAT, CHKB
6ceftriaxone46 1210.7CRP, PLAT
7spec-t469.7NPPB, PLAT, CHKB
8trapidil469.7PLAT, MMP9
9abciximab46 1210.6CHKB, PLAT, CRP
10omapatrilat469.6MMP9, PLAT
11clopidogrel46 52 25 1212.6CHKB, PLAT, CRP
12thyroxine46 2510.5NPPB, PLAT, CHKB
13tirofiban46 1210.4NPPB, CRP, PLAT
14perindopril46 52 1211.4PLAT, CRP, NPPB
15p005469.4NPPB, CRP, PLAT
16uric acid46 2510.4NPPB, CRP, CHKB
17pravastatin46 52 30 25 1213.4NPPB, CRP, CHKB
18losartan46 52 30 1212.4NPPB, CRP, PLAT
19ramipril46 1210.3CRP, NPPB
20valsartan46 62 30 1212.3NPPB, CRP
21p003469.3PLAT, CRP, NPPB
22prednisolone46 30 1211.3CHKB, CRP, NPPB
23homocysteine46 2510.3NPPB, CRP, PLAT
24phosphorylcholine46 2510.2CRP, CHKB
25aprotinin46 1210.2MMP9, PLAT, NPPB
26nacl469.2NPPB, PRF1, CHKB
27gabexate mesilate469.1MMP9, PLAT, CRP
28nitroglycerin46 1210.1CHKB, PLAT, CRP, NPPB
29prostacyclin469.1NPPB, CRP, PLAT
30aspirin46 52 30 2512.1CHKB, PLAT, CRP, NPPB
31alpha tocopherol469.1CRP, CHKB, MMP9
32fosinopril46 1210.0NPPB, CRP, MMP9
338-isoprostane468.9NPPB, CRP, MMP9
34pioglitazone30 46 52 1211.9MMP9, CRP, NPPB
35cholesterol46 30 25 1211.9CHKB, PRF1, PLAT, CRP
36cyclosporin a46 30 6210.8MMP9, CHKB, PLAT, NPPB
37fluvastatin46 52 30 1211.8MMP9, CHKB, PLAT, CRP
38simvastatin46 52 62 30 25 1213.8CRP, PLAT, CHKB, MMP9
39rosiglitazone30 46 52 25 1212.8NPPB, CRP, MMP9
40fibrinogen468.8MMP9, CHKB, PLAT, CRP
41cyclophosphamide46 52 1210.7NPPB, CRP, MMP9
42aspartate468.7MMP9, CHKB, PLAT, CRP
43p002468.6NPPB, CRP, PLAT, MMP9
44norepinephrine46 25 1210.6MMP9, CHKB, CRP, NPPB
45cycloheximide468.6MMP9, PRF1, PLAT, CRP
46lactate468.5MMP9, CHKB, CRP, NPPB
47testosterone46 62 25 1211.3MMP9, CHKB, CRP, NPPB
48atorvastatin46 52 30 25 1212.3NPPB, CRP, PLAT, CHKB, MMP9
49creatinine468.3MMP9, CHKB, PLAT, CRP, NPPB
50calcium46 52 25 1210.7FLNC, MMP9, CHKB, PRF1, CRP, NPPB

GO Terms for genes affiliated with Cardiac Rupture

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17Gene Ontology
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Cellular components related to Cardiac Rupture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2NPPB, CRP, PLAT, MMP9
2extracellular regionGO:0055767.5NPPB, CRP, PLAT, PRF1, MMP9

Products for genes affiliated with Cardiac Rupture

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiac Rupture

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet