Cardiac Sarcoidosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Cardiac Sarcoidosis

MalaCards based summary: Cardiac Sarcoidosis is related to dilated cardiomyopathy and pulmonary tuberculosis. An important gene associated with Cardiac Sarcoidosis is PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8), and among its related pathways are TRAF Pathway and IL12-mediated signaling events. The compounds lipoteichoic acid and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Cardiac Sarcoidosis

Sources:
⁹Disease Ontology, ⁶¹UMLS, ³⁹NCIt, ⁵⁶SNOMED-CT
See all sources

Cardiac Sarcoidosis, Aliases & Descriptions:

Name: Cardiac Sarcoidosis ⁹ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases

External Ids:

Disease Ontology⁹ DOID:13405

SNOMED-CT⁵⁶ 75403004

NCIt³⁹ C35589

UMLS⁶¹ C0392077

Related Diseases for Cardiac Sarcoidosis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 124)

id	Related Disease	Score	Top Affiliating Genes
1	dilated cardiomyopathy	30.4	ACE, HLA-DQB1, NPPB
2	pulmonary tuberculosis	30.1	IL12B, IFNG, HLA-DQB1
3	sarcoidosis	29.6	IFNG, TNF, LTA, TAP2, TAP1, S100A9
4	tuberculosis	29.4	HLA-DQB1, IL12B, TNF, IFNG, IL1B
5	atrioventricular block	10.5
6	degenerative disc disease	10.5	IL1B
7	pulpitis	10.5	IL1A
8	periodontal disease	10.4	TNF
9	celiac disease	10.4	HLA-DQB1, IL15
10	arrhythmogenic right ventricular cardiomyopathy	10.4
11	myocarditis	10.4
12	aneurysm	10.4
13	pleurisy	10.4	IL1B
14	oligohydramnios	10.3	ACE
15	mixed connective tissue disease	10.3	S100A8, S100A9
16	encephalitis	10.3	IL1B, IL12B
17	leishmaniasis	10.3	IFNG
18	giant cell myocarditis	10.3
19	asthma	10.3	IL12B, TNF
20	tonsillitis	10.3	LTA, IL1A
21	middle ear cholesteatoma	10.3	IL1A, S100A8
22	duodenal ulcer	10.3	S100A8, LTA
23	periodontitis	10.3	IL1B, IL1A
24	shigellosis	10.3	IL1B, LTA
25	skin disease	10.3	IL1B, IL1A
26	hypertrophic cardiomyopathy	10.2
27	dermatomyositis	10.2	IL1A, S100A9, S100A8
28	schizophrenia	10.2	LTA, TAP1, HLA-DQB1
29	bacterial vaginosis	10.2	IL1B, IL1A
30	spondylarthropathy	10.2	S100A8, TNF, S100A9
31	ankylosing spondylitis	10.2	TAP2, TAP1, TNF
32	sjogren's syndrome	10.2	TAP2, S100A9, S100A8, TAP1
33	lepromatous leprosy	10.2	IFNG, LTA
34	blau syndrome	10.2	IL1B, TNF
35	hypertensive heart disease	10.2	NPPB, ACE
36	aids dementia complex	10.2	TNF, IL1B
37	visceral leishmaniasis	10.2	IFNG, LTA
38	idiopathic edema	10.2	NPPB, ACE
39	alcoholic hepatitis	10.2	IL1A, TNF
40	gingival overgrowth	10.1	IL1B, IL1A
41	familial mediterranean fever	10.1	IL1B, TNF
42	gout	10.1	S100A9, IL1B
43	chorioamnionitis	10.1	TNF, IL1B
44	polymyositis	10.1	S100A9, S100A8, IL1A, IL15
45	gingivitis	10.1	IL1A, IL1B
46	adult respiratory distress syndrome	10.1	TNF, IL1B, LTA
47	tropical spastic paraparesis	10.1	IL15, IFNG
48	alopecia areata	10.1	IFNG, IL1A
49	autoimmune thyroiditis	10.1	IL12B, IFNG, PSMB8
50	bronchitis	10.1	S100A9, S100A8

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:

Symptoms for Cardiac Sarcoidosis

Drugs & Therapeutics for Cardiac Sarcoidosis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Cardiac Sarcoidosis

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Cardiac Sarcoidosis:

³²

Heart, Bone, Brain, Myeloid, T cells, Lymph node

Animal Models for Cardiac Sarcoidosis or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.7	LTA, ACE, IFNG, TNF, HLA-DQB1
2	tumorigenesis	MP:0002006	7.9	TNF, PSMB8, IFNG, ACE, IL12B, IL1B
3	cardiovascular system phenotype	MP:0005385	7.1	HLA-DQB1, TNF, IFNG, ACE, IL15, IL1B
4	homeostasis/metabolism phenotype	MP:0005376	6.9	HLA-DQB1, TNF, IFNG, ACE, IL12B, IL1B
5	hematopoietic system phenotype	MP:0005397	5.6	LTA, HLA-DMA, HLA-DQB1, TNF, PSMB8, IFNG
6	immune system phenotype	MP:0005387	5.5	ACE, IFNG, PSMB8, TNF, HLA-DQB1, HLA-DMA
7	mortality/aging	MP:0010768	5.4	ACE, IFNG, TNF, HLA-DQB1, HLA-DMA, IL15

Publications for Cardiac Sarcoidosis

Sources:
⁵¹PubMed
See all sources

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 357)

id	Title	Authors	Year
1	Cardiac sarcoidosis. (24969032)	Zipse M.M.... Sauer W.H.	2014
2	Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography. (24429936)	Hernandez Pampaloni M.... Botvinick E.	2014
3	Quantifying myocardial inflammation using F18-fluorodeoxyglucose positron emission tomography in cardiac sarcoidosis. (24942609)	Waller A.H.... Blankstein R.	2014
4	Visual findings of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with cardiac sarcoidosis. (25224185)	Ito K.... Hiroe M.	2014
5	The difficult diagnosis of isolated cardiac sarcoidosis: usefulness of an integrated MRI and PET approach. (23838000)	Galati G.... Rapezzi C.	2014
6	Cardiac Sarcoidosis: Electrophysiological Outcomes on Long-Term Follow-Up and the Role of the Implantable Cardioverter-Defibrillator. (24433308)	Mohsen A.... Saba Mbchb M.M.	2013
7	Efficacy of heparin loading during an 18F-FDG PET/CT examination to search for cardiac sarcoidosis activity. (23334129)	Ito K.... Hiroe M.	2013
8	The invisible made visible: multi-modality imaging in the evaluation of cardiac sarcoidosis. (23391582)	Joyce E.... Marsan N.A.	2013
9	Complete somatostatin-induced insulin suppression combined with heparin loading does not significantly suppress myocardial 18F-FDG uptake in patients with suspected cardiac sarcoidosis. (24132814)	Gormsen L.C.... Nielsen S.S.	2013
10	Malignant ventricular arrhythmia as the first manifestation of cardiac sarcoidosis. (24104986)	Alper A.T.... Erer H.B.	2013
11	Inactive cardiac sarcoidosis with characteristic findings on cardiac MRI. (24177462)	Hori Y.S.... Kanda J.	2013
12	Cardiac sarcoidosis. (23844704)	Zacek P.... Harrer J.	2013
13	Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia with high defibrillation threshold requiring subcutaneous shocking coil implantation. (21982156)	Mohsen A.... Jimenez A.	2012
14	Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (22944174)	Shafee M.A.... Shimokawa H.	2012
15	Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)	Birkenbach C.... Sperhake J.P.	2012
16	Cardiac sarcoidosis presenting with complete atrioventricular block and sustained monomorphic ventricular tachycardia. (22977456)	Lee J.M.... Choi D.J.	2012
17	Arrhythmias in cardiac sarcoidosis: diagnosis and treatment. (22186166)	Nery P.B.... Birnie D.H.	2012
18	Cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy. (21937273)	Chia P.L.... Walker B.	2012
19	Diagnosis of cardiac sarcoidosis through mismatched defects seen on N-13 NH3/F-18 FDG cardiac PET. (22064101)	Chen S.... Bokhari S.	2011
20	Cardiac sarcoidosis: a comprehensive review. (22291785)	Sekhri V.... Maguire G.P.	2011
21	Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)	Luk A.... Butany J.	2010
22	Cardiac sarcoidosis. (20665393)	Nunes H.... Valeyre D.	2010
23	Diagnosing cardiac sarcoidosis clinically without tissue confirmation. (19633746)	Sharma P.S.... Roberts W.C.	2009
24	Dual left ventricular restorations in a patient with cardiac sarcoidosis. (19380011)	Shimamoto T.... Komeda M.	2009
25	Multiple involvements of cardiac sarcoidosis in both left and right ventricles and papillary muscles detected by delayed-enhanced magnetic resonance imaging. (17689728)	Sato Y.... Hirayama A.	2008
26	Successful treatment of cardiac sarcoidosis with infliximab. (18671332)	Barnabe C.... Martin L.	2008
27	Exercise intolerance and multiple conduction abnormalities as first manifestation of cardiac sarcoidosis. (18791500)	Ruiz-Arango A.... Sharma G.K.	2008
28	Cardiac sarcoidosis: a case report. (19044177)	Silva J.R.... Santos O.	2008
29	An unappetizing dog bone: cardiac sarcoidosis presenting with heart block and unusual left ventricular bulging. (18065753)	Ghosh N.... Ross H.	2008
30	Complementary appearance of glucose and lipid metabolism in cardiac sarcoidosis. (16872698)	Wu Y.W.... Togashi K.	2007
31	Reversible exercise-induced advanced atrioventricular block due to cardiac sarcoidosis. (17199004)	RAPssig L.... Hohnloser S.H.	2007
32	Usefulness of late gadolinium enhancement combined with MRI and 67-Ga scintigraphy in the diagnosis of cardiac sarcoidosis and disease activity evaluation. (16868855)	Kiuchi S.... Yamashina A.	2007
33	Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis. (17895549)	Terasaki F.... Kitaura Y.	2007
34	Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)	Otsuka K.... Kitaura Y.	2007
35	The intricacies of cardiac sarcoidosis: a case report involving the coronary arteries and a review of the literature. (16844554)	Butany J.... Leong S.W.	2006
36	Images in cardiology. Biventricular involvement in cardiac sarcoidosis. (16230435)	Nakada Y.... Mochizuki S.	2005
37	Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis. (15881282)	Uemura A.... Hishida H.	2005
38	Cardiac sarcoidosis: there is no instant replay. (16002904)	Judson M.A.	2005
39	Diagnostic Value of PET in Cardiac Sarcoidosis. (15534072)	Smedema J.P.... Gorgels A.P.	2004
40	Cardiac sarcoidosis: two cases with autopsy findings. (16196153)	Wan Muhaizan W.M.... Daud M.S.	2004
41	Cardiac sarcoidosis detected by delayed-hyperenhancement magnetic resonance imaging. (15061637)	Nemeth M.A.... Flamm S.D.	2004
42	Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. (11577764)	Matsuo S.... Kinoshita M.	2001
43	Discrepancy between inducibility of ventricular tachycardia and activity of cardiac sarcoidosis. Requirement of defibrillator implantation for the inactive stage of cardiac sarcoidosis. (11518112)	Mezaki T.... Aizawa Y.	2001
44	HLA-DQB1*0601 is primarily associated with the susceptibility to cardiac sarcoidosis. (10958356)	Naruse T.K.... Inoko H.	2000
45	Incidence of cardiac sarcoidosis in Japanese patients with high-degree atrioventricular block. (9327691)	Yoshida Y.... Itoh T.	1997
46	Sudden death due to cardiac sarcoidosis in a case of suspected homicide. (8217872)	Ogbuihi S.... Brinkmann B.	1993
47	Cardiac sarcoidosis. (2355460)	Ueda M.... Ito T.	1990
48	Two dimensional echocardiography and left ventriculography in cardiac sarcoidosis. (2631668)	Bower S.P.... Thomson A.	1989
49	Cardiac sarcoidosis: two cases with ventricular tachycardia and review of cardiac involvement in sarcoid. (15227374)	Lam C.R.	1986
50	Cardiac sarcoidosis. Diagnosis with endomyocardial biopsy and treatment with corticosteroids. (677030)	Lorell B.... Mason J.W.	1978

Genes related to Cardiac Sarcoidosis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Cardiac Sarcoidosis:

(show all 16)

- Elite gene

id	Symbol	Description	Score	Implication
1	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8	20.61	GeneCards inferred via : Publications (show sections)
2	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	19.36	GeneCards inferred via : Publications (show sections)
3	LTA	lymphotoxin alpha	18.11	GeneCards inferred via : Publications (show sections)
4	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	16.86	GeneCards inferred via : Publications (show sections)
5	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	15.61	GeneCards inferred via : Publications (show sections)
6	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	14.36	GeneCards inferred via : Publications (show sections)
7	IL1A	interleukin 1, alpha	13.11	GeneCards inferred via : Publications (show sections)
8	NPPB	natriuretic peptide B	11.86	GeneCards inferred via : Publications (show sections)
9	IL1B	interleukin 1, beta	10.61	GeneCards inferred via : Publications (show sections)
10	ACE	angiotensin I converting enzyme	9.36	GeneCards inferred via : Publications (show sections)
11	IFNG	interferon, gamma	8.11	GeneCards inferred via : Publications (show sections)
12	TNF	tumor necrosis factor	6.86	GeneCards inferred via : Publications, Functions (show sections)
13	HLA-DMA	major histocompatibility complex, class II, DM alpha	5.61	GeneCards inferred via : Publications (show sections)
14	S100A9	S100 calcium binding protein A9	4.36	GeneCards inferred via : Publications (show sections)
15	S100A8	S100 calcium binding protein A8	3.11	GeneCards inferred via : Publications (show sections)
16	IL15	interleukin 15	1.86	GeneCards inferred via : Publications (show sections)

Products for genes related to Cardiac Sarcoidosis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	16	-	16	16
2	Novus Biologicals	16	15	16	-

Variations for Cardiac Sarcoidosis

Expression for genes affiliated with Cardiac Sarcoidosis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for genes affiliated with Cardiac Sarcoidosis

Sources:
⁴⁹PathCards, ⁵²QIAGEN, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters, ⁵³R&D Systems, ³⁰KEGG, ⁵⁴Reactome
See all sources

Pathways related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50) (show all 62)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	TRAF Pathway⁵² Show member pathways TNF Superfamily Pathway⁵² Toll-Like Receptors Pathway⁵²	9.5	IL12B, TNF, LTA
2	IL12-mediated signaling events³⁷ Show member pathways Immune response IL 12 induced IFN gamma production⁵⁹	9.5	IL1B, IFNG, IL12B
3	Th17 Differentiation⁵³ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³	9.5	IL12B, IFNG, IL1B
4	Type II interferon signaling (IFNG)³⁷	9.5	TAP1, IL1B, IFNG
5	Legionellosis³⁰	9.4	IL1B, IL12B, TNF
6	Immune response Antigen presentation by MHC class II⁵⁹ Show member pathways Immune response IL 22 signaling pathway⁵⁹ G protein signaling N RAS regulation pathway⁵⁹ IL-22 Pathway⁵²	9.4	HLA-DMA, HLA-DQB1, IL12B
7	NF-kappa B signaling pathway³⁰	9.4	IL1B, TNF, LTA
8	Salmonella infection³⁰ Show member pathways Shigellosis³⁰	9.4	IL1A, IFNG, IL1B
9	Senescence and Autophagy³⁷	9.4	IFNG, IL1A, IL1B
10	Hematopoietic cell lineage³⁰	9.4	TNF, IL1A, IL1B
11	IL-10 Pathway⁵²	9.4	TNF, IL1B, IL1A
12	Cellular Transformation by HTLV1⁵² Show member pathways Activation of NF-KappaB by PKR⁵²	9.4	IFNG, LTA, TNF
13	Malaria³⁰	9.3	TNF, IFNG, IL1B
14	Selenium Pathway³⁷ Show member pathways thioredoxin pathway³⁷	9.3	TNF, IL1B, IFNG
15	Phagosome³⁰	9.2	HLA-DMA, HLA-DQB1, TAP1, TAP2
16	Pertussis³⁰	9.1	IL1B, IL1A, IL12B, TNF
17	Apoptosis⁵⁴ Show member pathways 14-3-3 Induced Apoptosis⁵² Apoptosis³⁰	9.1	LTA, TNF, IL1A, IL1B
18	NF-KappaB Family Pathway⁵² Show member pathways NF-KappaB (p50-p65) Pathway⁵²	9.1	IL1A, IL1B, LTA, TNF
19	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³	9.1	TNF, IL15, IFNG
20	Immune response IL 23 signaling pathway⁵⁹ Show member pathways IL23-mediated signaling events³⁷ Angiopoietin-TIE2 Signaling⁵² Immune response IL 10 signaling pathway⁵⁹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development PDGF signaling via STATs and NF kB⁵⁹ Development Angiopoietin Tie2 signaling⁵⁹	9.0	IL1B, IL12B, IFNG, TNF
21	Amoebiasis³⁰	9.0	TNF, IFNG, IL1B, IL12B
22	African trypanosomiasis³⁰	9.0	IL1B, TNF, IFNG, IL12B
23	MSP-RON Signaling⁵²	9.0	TNF, IL1B, IL12B, IFNG
24	Osteoclast differentiation³⁰	9.0	TNF, IL1A, IFNG, IL1B
25	B Cell Receptor Signaling Pathway³⁷ Show member pathways B cell receptor signaling pathway³⁰ BCR signaling pathway³⁷ TCR Signaling Pathway³⁷ T cell receptor signaling pathway³⁰	9.0	IFNG, TNF, IL1A, IL1B
26	Spinal Cord Injury³⁷	9.0	IL1A, IFNG, TNF, IL1B
27	Transcription Role of VDR in regulation of genes involved in osteoporosis⁵⁹	9.0	TNF, IL1B, IL1A, IFNG
28	Toll Comparative Pathway⁵² Show member pathways Immune response MIF in innate immunity response⁵⁹ iNOS Signaling⁵² TLR-TRIF Pathway⁵² IL-1 Pathway⁵²	9.0	TNF, IL1B, IFNG, IL1A
29	Class I MHC mediated antigen processing and presentation⁵⁴ Show member pathways Ubiquitin mediated proteolysis³⁰ Antigen processing- Ubiquitination and Proteasome degradation⁵⁴ Adaptive Immune System⁵⁴	8.9	HLA-DMA, TAP1, HLA-DQB1, PSMB8, TAP2
30	Interferon Signaling⁵⁴ Show member pathways ISG15 antiviral mechanism⁵⁴ Cytokine Signaling in Immune system⁵⁴ Regulation of IFNG signaling⁵⁴ Interferon gamma signaling⁵⁴ Antiviral mechanism by IFN-stimulated genes⁵⁴	8.9	IFNG, IL1B, PSMB8, IL1A, HLA-DQB1
31	TNF signaling pathway³⁰	8.9	TNF, IL15, IL1B, LTA
32	CDK-mediated phosphorylation and removal of Cdc6⁵⁴ Show member pathways APC/C-mediated degradation of cell cycle proteins⁵⁴ Antigen processing-Cross presentation⁵⁴ Autodegradation of the E3 ubiquitin ligase COP1⁵⁴ Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)⁵⁴ SCF-beta-TrCP mediated degradation of Emi1⁵⁴ Regulation of Apoptosis⁵⁴ Regulation of PAK-2p34 activity by PS-GAP/RHG10⁵⁴ Destabilization of mRNA by KSRP⁵⁴ DNA Replication Pre-Initiation⁵⁴ Cross-presentation of particulate exogenous antigens (phagosomes)⁵⁴ Switching of origins to a post-replicative state⁵⁴ Proteasome Degradation³⁷ Regulation of mRNA Stability by Proteins that Bind AU-rich Elements⁵⁴ M/G1 Transition⁵⁴ Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase⁵⁴ CDC6 association with the ORC-origin complex⁵⁴ S Phase⁵⁴ Degradation of beta-catenin by the destruction complex⁵⁴ Immune response Antigen presentation by MHC class I⁵⁹ Phosphorylation of the APC/C⁵⁴ Regulation of mitotic cell cycle⁵⁴ Cyclin A-Cdk2-associated events at S phase entry⁵⁴ Regulation of APC/C activators between G1/S and early anaphase⁵⁴ APC/C-Cdc20 mediated degradation of mitotic proteins⁵⁴ Proteasome³⁰ Association of licensing factors with the pre-replicative complex⁵⁴ ER-Phagosome pathway⁵⁴ CDT1 association with the CDC6-ORC-origin complex⁵⁴ Cell Cycle Checkpoints⁵⁴ Cyclin E associated events during G1/S transition⁵⁴ Beta-catenin phosphorylation cascade⁵⁴ Parkinson's Disease Pathway⁵² APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1⁵⁴ APC/C-Cdc20 mediated degradation of Securin⁵⁴ Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins⁵⁴ Activation of NF-kappaB in B Cells⁵⁴ Vpu mediated degradation of CD4⁵⁴ Regulation of activated PAK-2p34 by proteasome mediated degradation⁵⁴ p53-Independent G1/S DNA damage checkpoint⁵⁴ Regulation of ornithine decarboxylase (ODC)⁵⁴ Stabilization of mRNA by HuR⁵⁴ WNT5A-dependent internalization of FZD4⁵⁴ Destabilization of mRNA by Tristetraprolin (TTP)⁵⁴ SCF(Skp2)-mediated degradation of p27/p21⁵⁴ Regulation of DNA replication⁵⁴ Role of DCC in regulating apoptosis⁵⁴ Ubiquitin-dependent degradation of Cyclin D⁵⁴ Ubiquitin Mediated Degradation of Phosphorylated Cdc25A⁵⁴ p53-Dependent G1/S DNA damage checkpoint⁵⁴ p53-Dependent G1 DNA Damage Response⁵⁴ Apoptosis⁵⁴ DNA Replication⁵⁴ Vif-mediated degradation of APOBEC3G⁵⁴ Destabilization of mRNA by AUF1 (hnRNP D0)⁵⁴ p53-Independent DNA Damage Response⁵⁴ Cross-presentation of soluble exogenous antigens (endosomes)⁵⁴ Removal of licensing factors from origins⁵⁴ Endosomal/Vacuolar pathway⁵⁴ Stabilization of p53⁵⁴ Assembly of the pre-replicative complex⁵⁴ Ubiquitin-dependent degradation of Cyclin D1⁵⁴ PCP/CE pathway⁵⁴ G1/S DNA Damage Checkpoints⁵⁴ Orc1 removal from chromatin⁵⁴ Asymmetric localization of PCP proteins⁵⁴ Autodegradation of Cdh1 by Cdh1-APC/C⁵⁴ Establishment of Sister Chromatid Cohesion⁵⁴ WNT5A-dependent internalization of FZD2, FZD5 and ROR2⁵⁴ Synthesis of DNA⁵⁴	8.9	PSMB8, IFNG, TNF, TAP1, TAP2
33	Th1 Differentiation⁵³ Show member pathways IL27-mediated signaling events³⁷	8.8	LTA, TNF, IFNG, IL12B, IL1B
34	Immune response Bacterial infections in normal airways⁵⁹ Show member pathways Transcription NF kB signaling pathway⁵⁹ Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response⁵⁹ Bacterial infections in CF airways⁵⁹ IL 1 beta dependent CFTR expression⁵⁹	8.7	IL1B, IFNG, TNF, IL1A, LTA
35	4-1BB Pathway⁵² Show member pathways CD40 Signaling⁵² PKR Pathway⁵² NF-kappaB Activation by Viruses⁵² CMV and MAPK Pathways⁵² SUMO Pathway⁵² NF-KappaB Activation by EBV⁵² TNFR2 Pathway⁵² CD27 Pathway⁵²	8.7	TNF, IL1A, IL1B, IFNG, LTA
36	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	8.7	ACE, IL1B, IL12B, TNF, IFNG
37	HTLV-I infection³⁰	8.5	HLA-DMA, HLA-DQB1, LTA, IL15, TNF
38	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.4	LTA, IL15, IL12B, IL1A, IL1B, TNF
39	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.4	IL1A, IL1B, LTA, TNF, IL12B, IL15
40	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	8.4	LTA, IL1A, IL1B, IL12B, IL15, TNF
41	Cytokines and Inflammatory Response³⁷	8.2	TNF, IL15, IL12B, IL1A, IFNG, IL1B
42	ErbB4 Pathway⁵² Show member pathways UVC-Induced MAPK Signaling⁵² FGF Pathway⁵² LPS Stimulated MAPK Signaling⁵² Growth Hormone Signaling⁵² HMGB1 Pathway⁵² PACAP Signaling⁵² IL-4 Pathway⁵² Prolactin Signaling⁵² Thrombopoietin Pathway⁵² ErbB2-ErbB3 Heterodimers⁵² IL-2 Pathway⁵² PI3K Signaling in B-Lymphocyte⁵² TREM1 Pathway⁵² ErbB Family Pathway⁵²	8.2	IFNG, HLA-DQB1, IL1B, TNF, IL1A, HLA-DMA
43	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.0	IL1B, LTA, IL1A, IL12B, IL15, TNF
44	Cytokine Network⁵²	8.0	LTA, IL1A, IL1B, IL12B, IL15, TNF
45	Leishmaniasis³⁰ Show member pathways Toxoplasmosis³⁰ Inflammatory bowel disease (IBD)³⁰	7.9	TNF, HLA-DMA, HLA-DQB1, IL1A, IL1B, IL12B
46	Tuberculosis³⁰	7.9	TNF, HLA-DMA, HLA-DQB1, IFNG, IL1A, IL12B
47	TGF-Beta Pathway⁵² Show member pathways SOCS Pathway⁵² JAK-STAT Pathway⁵² Regulation of eIF4 and p70S6K⁵² JNK Pathway⁵² MAPK Family Pathway⁵²	7.7	LTA, IL1A, IL1B, IL12B, IL15, IFNG
48	Rheumatoid arthritis³⁰	7.6	TNF, HLA-DMA, IL1A, IL1B, IL15, IFNG
49	Influenza A³⁰ Show member pathways Measles³⁰ Herpes simplex infection³⁰	6.6	TNF, HLA-DMA, HLA-DQB1, IFNG, IL15, LTA
50	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	6.6	IL15, HLA-DMA, HLA-DQB1, TNF, IFNG, IL12B

Compounds for genes affiliated with Cardiac Sarcoidosis

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ⁵⁰PharmGKB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ³BitterDB, ²⁵HMDB
See all sources

Compounds related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50) (show all 141)

id	Compound	Score	Top Affiliating Genes
1	lipoteichoic acid⁴⁴	9.5	LTA, TNF, IL12B, IL1B
2	sulfasalazine²⁹ ⁴⁴ ⁵⁰ ¹²	12.5	IL1A, IL12B, IL1B, TNF
3	imiquimod⁴⁴ ⁶⁰ ²⁹ ¹²	12.5	IL1A, IL12B, IFNG, TNF
4	gold sodium thiomalate⁴⁴	9.4	IL1B, IFNG, IL1A, TNF
5	polymyxin b⁴⁴	9.3	IL1B, TNF, IFNG, IL1A
6	tenidap⁴⁴ ²⁹	10.3	IL1B, TNF, IL1A
7	okt3⁴⁴	9.2	LTA, IL15, IFNG, TNF
8	ivig⁴⁴	9.1	LTA, IL1B, IL1A, TNF, IFNG
9	neopterin⁴⁴	9.1	LTA, IL1B, IFNG, TNF, IL1A
10	l-nmma⁴⁴	9.1	TNF, NPPB, IL1B, IFNG
11	herbimycin a⁴⁴ ⁶⁰	10.0	IL1A, IL1B, IFNG, LTA, TNF
12	il-12⁴⁴	8.9	IL1B, IL12B, IFNG, TNF, IL15
13	poly(i-c)⁴⁴	8.9	IL1B, IL15, IL12B, IFNG, TNF
14	peptidoglycan⁴⁴ ²⁹	9.9	TNF, IL15, IL12B, IL1B
15	etanercept⁴⁴ ⁵⁰ ¹²	10.9	TNF, IL15, LTA, IL1B, IFNG
16	infliximab⁴⁴ ⁵⁰ ¹²	10.9	LTA, IFNG, IL1B, IL15, TNF
17	prostacyclin⁴⁴	8.9	NPPB, IL1B, ACE, TNF, IL1A
18	gm-csf⁴⁴ ²⁹	9.9	IL1A, TNF, IL15, IFNG, IL1B
19	p005⁴⁴	8.9	S100A8, LTA, NPPB, IL15
20	ccl3⁴⁴ ²⁹	9.8	IL1B, IL15, IFNG, IL1A, TNF
21	ionomycin⁴⁴	8.8	IL15, LTA, IL1A, IFNG, TNF
22	git 27⁶⁰	8.8	S100A8, IL1A, IL1B, S100A9
23	4-ipp⁶⁰	8.8	S100A8, S100A9, IL1A, IL1B
24	sb 203580⁴⁴ ⁶⁰	9.8	IL12B, IL1A, NPPB, TNF, IFNG, IL1B
25	hydrocortisone⁴⁴ ³ ⁶⁰ ¹²	11.8	IL15, IL1B, IFNG, IL1A, TNF
26	indomethacin⁴⁴ ²⁹ ⁶⁰ ¹²	11.8	IL1B, NPPB, IL1A, IFNG, TNF, LTA
27	as 101⁴⁴ ⁶⁰	9.8	S100A8, IL1B, IL1A, S100A9
28	fmlp⁴⁴	8.7	TNF, IL1B, S100A9, LTA, IL1A
29	actinomycin d⁴⁴	8.7	IL1A, IFNG, TNF, IL1B, LTA, NPPB
30	polyinosinic-polycytidylic acid⁴⁴	8.7	IL12B, IL1B, IL1A, IL15, TNF, IFNG
31	pentoxifylline⁴⁴ ¹²	9.6	IFNG, TNF, IL12B, LTA, NPPB, IL1A
32	il 10⁴⁴	8.4	IL1B, IL12B, TNF, IFNG, IL15, IL1A
33	pirfenidone⁴⁴ ⁶⁰	9.4	IFNG, IL1A, S100A9, S100A8, IL1B
34	monosodium urate⁴⁴	8.4	IL1B, S100A8, S100A9
35	cyclosporin a⁴⁴ ²⁹ ⁶⁰	10.4	IL15, TNF, IFNG, IL1A, NPPB, LTA
36	cycloheximide⁴⁴	8.3	IL1A, IL12B, TNF, IFNG, LTA, IL1B
37	rantes⁴⁴	8.3	IL1B, IL1A, IL15, S100A8, IFNG, IL12B
38	thymidine⁴⁴ ²⁵	9.1	NPPB, IL15, IL1A, IL1B, IFNG, TNF
39	pge2⁴⁴	8.1	TNF, IFNG, IL15, IL12B, IL1A, NPPB
40	vegf⁴⁴	8.1	IFNG, IL15, TNF, IL1B, LTA, IL1A
41	thalidomide⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.9	IL1B, IL1A, IFNG, S100A8, S100A9, TNF
42	histamine⁴⁴ ²⁹ ²⁵	9.9	IL15, TNF, S100A8, IL1B, NPPB, IFNG
43	arachidonic acid⁴⁴ ²⁹ ²⁵ ¹²	10.9	IL1A, LTA, S100A8, S100A9, TNF, IL1B
44	oligonucleotide⁴⁴	7.8	HLA-DQB1, HLA-DMA, IL15, S100A8, TAP1, TAP2
45	calcitriol⁴⁴ ⁶⁰ ²⁵ ¹²	10.7	TNF, IFNG, LTA, S100A8, IL1A, IL1B
46	endotoxin⁴⁴	7.5	IL12B, IL1B, IL1A, S100A9, S100A8, LTA
47	retinoic acid⁴⁴ ²⁵	8.1	S100A8, IL15, IFNG, TNF, S100A9, IL1B
48	lipid⁴⁴	7.0	LTA, NPPB, S100A9, IL12B, IL15, ACE
49	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	9.9	TNF, NPPB, S100A9, S100A8, IL1A, IL1B
50	nitric oxide⁴⁴ ²⁵ ¹²	8.3	IFNG, ACE, IL15, IL12B, IL1A, S100A9

GO Terms for genes affiliated with Cardiac Sarcoidosis

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	TAP complex	GO:042825	9.9	TAP1, TAP2
2	MHC class II protein complex	GO:042613	9.4	HLA-DQB1, HLA-DMA
3	external side of plasma membrane	GO:009897	9.2	ACE, IFNG, TNF
4	extracellular region	GO:005576	6.3	TNF, IFNG, ACE, IL15, IL1B, IL1A
5	extracellular space	GO:005615	5.9	LTA, TNF, IFNG, ACE, IL15, IL12B

Biological processes related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50) (show all 71)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol to ER transport	GO:046967	10.3	TAP1, TAP2
2	oligopeptide transmembrane transport	GO:035672	10.3	TAP1, TAP2
3	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:019885	10.3	TAP1, TAP2
4	intracellular transport of viral protein in host cell	GO:019060	10.3	TAP1, TAP2
5	fever generation	GO:001660	10.2	IL1B, IL1A
6	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:032725	10.2	IL12B, IL1B
7	positive regulation of chronic inflammatory response to antigenic stimulus	GO:002876	10.2	TNF, LTA
8	positive regulation of T cell mediated cytotoxicity	GO:001916	10.1	TAP2, TAP1, IL12B
9	sequestering of triglyceride	GO:030730	10.0	TNF, IL1B
10	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO:002925	10.0	TNF, LTA
11	positive regulation of tissue remodeling	GO:034105	10.0	IL15, IL12B
12	peptide transport	GO:015833	10.0	TAP1, TAP2
13	positive regulation of natural killer cell proliferation	GO:032819	10.0	IL15, IL12B
14	positive regulation of heterotypic cell-cell adhesion	GO:034116	10.0	TNF, IL1B
15	positive regulation of fever generation	GO:031622	10.0	TNF, IL1B
16	positive regulation of vitamin D biosynthetic process	GO:060557	10.0	TNF, IFNG
17	ectopic germ cell programmed cell death	GO:035234	10.0	IL1B, IL1A
18	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.0	TAP2, TAP1, PSMB8
19	positive regulation of smooth muscle cell apoptotic process	GO:034393	9.9	IFNG, IL12B
20	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.9	IFNG, IL1B
21	positive regulation of NF-kappaB import into nucleus	GO:042346	9.9	TNF, IL12B, IL1B
22	positive regulation of osteoclast differentiation	GO:045672	9.8	TNF, IFNG, IL12B
23	positive regulation of mitosis	GO:045840	9.8	IL1A, IL1B, TNF
24	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.8	IL1A, IL1B, TNF
25	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	9.7	TAP2, TAP1, PSMB8
26	negative regulation of smooth muscle cell proliferation	GO:048662	9.7	IL12B, IL15, IFNG
27	humoral immune response	GO:006959	9.7	LTA, IFNG, TNF
28	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IFNG, IL1B
29	positive regulation of chemokine biosynthetic process	GO:045080	9.7	IL1B, IFNG, TNF
30	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.7	TNF, IFNG, IL1B
31	positive regulation of nitric oxide biosynthetic process	GO:045429	9.7	TNF, IFNG, IL1B
32	positive regulation of interferon-gamma production	GO:032729	9.6	LTA, IL1B, IL12B, TNF
33	positive regulation of immune response	GO:050778	9.6	HLA-DMA, IL15
34	negative regulation of growth of symbiont in host	GO:044130	9.6	LTA, IL12B, IFNG, TNF
35	negative regulation of interleukin-17 production	GO:032700	9.5	IL12B, IFNG
36	neutrophil aggregation	GO:070488	9.4	S100A9, S100A8
37	chemokine production	GO:032602	9.4	S100A9, S100A8
38	positive regulation of T cell proliferation	GO:042102	9.4	IL1B, IL12B, IL15, IFNG
39	sequestering of zinc ion	GO:032119	9.4	S100A9, S100A8
40	cytokine-mediated signaling pathway	GO:019221	9.3	HLA-DQB1, PSMB8, IFNG, IL1B, IL1A
41	leukocyte migration involved in inflammatory response	GO:002523	9.3	S100A9, S100A8
42	regulation of insulin secretion	GO:050796	9.2	TNF, IFNG, IL1B
43	cell-cell signaling	GO:007267	9.1	IL15, IL1B, S100A9, LTA
44	immune response	GO:006955	9.0	IL1A, IL1B, IL15, HLA-DQB1
45	apoptotic process	GO:006915	8.9	TNF, PSMB8, IFNG, IL1B, IL1A, LTA
46	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	8.8	TNF, S100A9, S100A8
47	neutrophil chemotaxis	GO:030593	8.7	IFNG, IL1B, S100A9, S100A8
48	positive regulation of inflammatory response	GO:050729	8.7	IL15, IL12B, S100A9, S100A8
49	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	TNF, IL1B, S100A9, S100A8
50	inflammatory response	GO:006954	7.9	TNF, IL15, IL1B, IL1A, S100A9, S100A8

Molecular functions related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	tapasin binding	GO:046980	10.2	TAP1, TAP2
2	MHC class Ib protein binding	GO:023029	10.2	TAP1, TAP2
3	peptide transporter activity	GO:015197	10.2	TAP1, TAP2
4	oligopeptide-transporting ATPase activity	GO:015421	10.2	TAP1, TAP2
5	TAP2 binding	GO:046979	10.1	TAP1, TAP2
6	TAP1 binding	GO:046978	10.1	TAP1, TAP2
7	peptide antigen binding	GO:042605	10.0	TAP2, TAP1
8	MHC class I protein binding	GO:042288	9.9	TAP2, TAP1
9	interleukin-1 receptor binding	GO:005149	9.8	IL1B, IL1A
10	tumor necrosis factor receptor binding	GO:005164	9.5	LTA, TNF
11	Toll-like receptor 4 binding	GO:035662	9.3	S100A9, S100A8
12	arachidonic acid binding	GO:050544	9.2	S100A9, S100A8
13	RAGE receptor binding	GO:050786	9.1	S100A8, S100A9
14	cytokine activity	GO:005125	8.3	LTA, TNF, IFNG, IL15, IL12B, IL1B
15	protein binding	GO:005515	6.5	IL15, ACE, PSMB8, TNF, IL12B, IL1A

Products for genes affiliated with Cardiac Sarcoidosis

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Kits and Assays

Sources for Cardiac Sarcoidosis

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: CRD003 MIFTS: 51	Cardiac Sarcoidosis malady Immune diseases category
16 genes, 6 tissues, 124 related diseases, clinical trials Download this MalaCard Expand all tables

Cardiac Sarcoidosis malady