MCID: CRD003
MIFTS: 42

Cardiac Sarcoidosis malady

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

Aliases & Descriptions for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 47 C35589
SNOMED-CT 64 75403004
UMLS 69 C0392077

Summaries for Cardiac Sarcoidosis

MalaCards based summary : Cardiac Sarcoidosis is related to pneumoconiosis and aseptic meningitis. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Benzocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and lymph node, and related phenotypes are hematopoietic system and immune system

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
id Related Disease Score Top Affiliating Genes
1 pneumoconiosis 10.2 TNC TNF
2 aseptic meningitis 10.2 TAP2 TNF
3 pseudo-meigs syndrome 10.2 PSMB9 TNF
4 aortic atherosclerosis 10.2 IL5 TNF
5 urethral intrinsic sphincter deficiency 10.1 IL5 TNF
6 cardiomyopathy 10.1
7 bile duct signet ring cell carcinoma 10.1 IL5 TNF
8 intussusception 10.1 IL1B TNF
9 tau syndrome 10.1 IL1B TNF
10 brown shrimp allergy 10.1 IL5 LGALS3
11 stocco dos santos syndrome 10.1 IL1B TNF
12 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B TNF
13 twin-to-twin transfusion syndrome 10.1 IL1B TNF
14 warthin tumor 10.1 IL1B TNF
15 anal paget's disease 10.1 IL1B TNF
16 cataract 10.1 IL1B TNF
17 bipolar i disorder 10.1 IL1B TNF
18 human immunodeficiency virus infectious disease 10.1 IL1B TNF
19 cerebellar disease 10.1 IL1B TNF
20 hyperparathyroidism 10.1 IL5 LGALS3
21 tinea capitis 10.1 IL1B TNF
22 amyotrophic lateral sclerosis type 14 10.1 IL1B TNF
23 atrioventricular block 10.1
24 measles 10.1 IL1B TNF
25 parkinson disease 11 10.1 IL1B TNF
26 dextrocardia 10.1 IL1B TNF
27 meier-gorlin syndrome 3 10.1 IL1B TNF
28 hypoparathyroidism-retardation-dysmorphism syndrome 10.0 IL1B TNF
29 gastroduodenal crohn's disease 10.0 IL1B TNF
30 childhood endodermal sinus tumor 10.0 IL1B TNF
31 steroid dehydrogenase deficiency dental anomalies 10.0 IL1B TNF
32 mikulicz disease 10.0 IL1B TNF
33 senile reticular retinal degeneration 10.0 IL1B TNF
34 acquired thrombocytopenia 10.0 IL1B TNF
35 benign neonatal seizures 10.0 IL1B TNF
36 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.0 IL1B TNF
37 gonococcal endophthalmia 10.0 IL1B TNF
38 idiopathic corneal edema 10.0 IL1B TNC
39 ectodermal dysplasia bartalos type 10.0 IL1B TNF
40 pyloric stenosis, infantile hypertrophic, 2 10.0 IL1B TNF
41 mineral metabolism disease 10.0 IL1B TNF
42 common peroneal nerve lesion 10.0 IL1B IL5
43 migraine with aura 9.9 IL1B TNF
44 astrocytoma 9.9 IL5 TNF
45 histoplasmosis retinitis 9.9 IL1B IL5
46 aneurysm 9.9
47 rickettsialpox 9.9 IL1B TNF
48 autosomal recessive type iv ehlers-danlos syndrome 9.9 IL1B TNF
49 neuropathy 9.9 IL1B TNF
50 aortic aneurysm, familial thoracic 6 9.9 IL1B TNC TNF

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 IL1B IL5 LGALS3 PSMB8 PSMB9 TAP2
2 immune system MP:0005387 9.5 IL1B IL5 LGALS3 PSMB8 PSMB9 TAP2
3 neoplasm MP:0002006 9.1 IL1B IL5 LGALS3 PSMB8 PSMB9 TNF

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
4 tannic acid Approved, Nutraceutical Phase 4
5 Anesthetics Phase 4
6 Anesthetics, General Phase 4
7 Anesthetics, Intravenous Phase 4
8 Central Nervous System Depressants Phase 4
9 Hypnotics and Sedatives Phase 4
10 Anti-Inflammatory Agents Phase 4,Phase 2
11 Antineoplastic Agents, Hormonal Phase 4,Phase 2
12 glucocorticoids Phase 4,Phase 2
13 Hormone Antagonists Phase 4,Phase 2
14 Hormones Phase 4,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
16 Omega 3 Fatty Acid Nutraceutical Phase 4
17
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
18
Bosentan Approved, Investigational Phase 2, Phase 3 147536-97-8 104865
19 Ferrosoferric Oxide Phase 2, Phase 3
20 Hematinics Phase 2, Phase 3
21 Parenteral Nutrition Solutions Phase 2, Phase 3
22 Pharmaceutical Solutions Phase 2, Phase 3
23 Adrenergic Agents Phase 2, Phase 3,Phase 1
24 Adrenergic Antagonists Phase 2, Phase 3,Phase 1
25 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
26 Adrenergic beta-Antagonists Phase 2, Phase 3,Phase 1
27 Anti-Arrhythmia Agents Phase 2, Phase 3,Phase 1
28 Antihypertensive Agents Phase 2, Phase 3, Phase 1
29 Autonomic Agents Phase 2, Phase 3
30 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
31 Peripheral Nervous System Agents Phase 2, Phase 3
32 Sympatholytics Phase 2, Phase 3
33 Endothelin Receptor Antagonists Phase 2, Phase 3
34 Bone Density Conservation Agents Phase 2, Phase 3
35 Calcium, Dietary Phase 2, Phase 3
36
Nitric Oxide Approved Phase 2 10102-43-9 145068
37
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
38
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
39
Dapsone Approved, Investigational Phase 2 80-08-0 2955
40
Azithromycin Approved Phase 2 83905-01-5 55185 53477736 447043
41
Ethambutol Approved Phase 2 74-55-5 3279 14052
42
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
43
Ofloxacin Approved Phase 2 82419-36-1 4583
44
Rifabutin Approved Phase 2 72559-06-9 6323490
45
Rifampin Approved Phase 2 13292-46-1 5458213 5381226
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
47
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
48
Riboflavin Approved, Nutraceutical, Vet_approved Phase 2 83-88-5 493570
49 Anticholesteremic Agents Phase 2
50 Antimetabolites Phase 2

Interventional clinical trials:

(show all 45)
id Name Status NCT ID Phase
1 Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy Completed NCT02246023 Phase 4
2 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
3 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4
4 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3
5 Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) Completed NCT01052428 Phase 2, Phase 3
6 Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary Hypertension Completed NCT00581607 Phase 2, Phase 3
7 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
8 Atorvastatin to Treat Pulmonary Sarcoidosis Completed NCT00279708 Phase 2
9 Treatment of Pulmonary Sarcoidosis With Pentoxifylline Completed NCT00001877 Phase 2
10 Diffuse Fibrotic Lung Disease Completed NCT00000596 Phase 2
11 A Clinical Study to Assess the Safety, Tolerability, and Activity of Oral SRT2104 Capsules Administered for 28 Days to Subjects With Type 2 Diabetes Mellitus Completed NCT01018017 Phase 2
12 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Recruiting NCT03048097 Phase 2
13 Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis Recruiting NCT02024555 Phase 2
14 PET/MR Imaging of Cardiac Sarcoidosis or Inflammation Not yet recruiting NCT03103490 Phase 2
15 Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability Suspended NCT01615484 Phase 2
16 Hematopoietic Stem Cell Support in Patients With Refractory Sarcoidosis Terminated NCT00282438 Phase 1, Phase 2
17 Safety, Pharmacokinetic and Pharmacodynamic Study of COR-1, an Anti-ß1 Receptor Antibody Cyclopeptide Completed NCT01043146 Phase 1
18 Effects of Propranolol (vs. Placebo) on Information Processing During Presentation of Emotionally Arousing Pictures Completed NCT02509559 Phase 1
19 Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study Unknown status NCT01384123
20 Cardiac Sarcoidosis: FDG PET vs. Ga-DOTANOC PET Completed NCT01729169
21 Cardiac Sarcoidosis and FDG-PET Completed NCT00958087
22 Genomic Research in Sarcoidosis Completed NCT01831739
23 A Case Controlled Etiologic Study of Sarcoidosis (ACCESS) Completed NCT00005276
24 Genetic Epidemiology of Sarcoidosis Completed NCT00005531
25 Sarcoid Genetic Analysis (SAGA) Completed NCT00005542
26 Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases Completed NCT00366509
27 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
28 Pathogen Specific Immunity in Patients With Sarcoidosis Completed NCT00217789
29 Genomic Research in Alpha-1 Antitrypsin Deficiency Completed NCT01832220
30 A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma Completed NCT01097954
31 Breath Test for Early Detection of Lung Cancer Completed NCT00639067
32 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Recruiting NCT02812849
33 Cardiac Sarcoidosis Multi-Center Prospective Cohort Recruiting NCT01477359
34 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Recruiting NCT02546388
35 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
36 Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis Recruiting NCT01745237
37 Role of Genetic Factors in the Development of Lung Disease Recruiting NCT00001532
38 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416
39 Non-Invasive Characterization in Cardiac Sarcoidosis Active, not recruiting NCT02017522
40 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Active, not recruiting NCT01648933
41 Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Enrolling by invitation NCT01013311
42 Cohort Description of Younger With AV-block Not yet recruiting NCT03024047
43 18F-FDG PET Imaging in Cardiac Sarcoidosis No longer available NCT01764191
44 Treatment of Renal Sarcoidosis by Methylprednisolone Bolus Terminated NCT01652417
45 Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability Terminated NCT01241942

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

39
Heart, Monocytes, Lymph Node, T Cells, Testes, Myeloid, Brain

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 465)
id Title Authors Year
1
Serial FDG-PET scans help to identify steroid resistance in cardiac sarcoidosis. ( 27886616 )
2017
2
The role of serial FDG PET for assessing therapeutic response in patients with cardiac sarcoidosis. ( 27813028 )
2017
3
A complete heart block in a young male: a case report and review of literature of cardiac sarcoidosis. ( 27817119 )
2017
4
Impact of early initiation of corticosteroid therapy on cardiac function and rhythm in patients with cardiac sarcoidosis. ( 27836297 )
2017
5
Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis. ( 27922863 )
2017
6
Multimodality imaging in the diagnosis and management of cardiac sarcoidosis. ( 27837455 )
2017
7
Spontaneous regression of cardiac sarcoidosis resulting in total occlusion of coronary artery and ventricular aneurysm. ( 28063417 )
2017
8
Cardiac sarcoidosis resembling panic disorder: a case report. ( 28086847 )
2017
9
Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy. ( 28438355 )
2017
10
Presence of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Among Patients With Suspected Cardiac Sarcoidosis Is Associated With Adverse Cardiovascular Prognosis: A Systematic Review and Meta-Analysis. ( 27621357 )
2016
11
Cholesterol metabolism in cardiac sarcoidosis. ( 27035112 )
2016
12
Detecting Cardiac Sarcoidosis with a Right Atrial Mass Using Transthoracic Echocardiography. ( 26875960 )
2016
13
Steroid Therapy Ameliorated Myocardial Fatty Acid Metabolism With Recovery of Complete Atrioventricular Block in Cardiac Sarcoidosis. ( 26973088 )
2016
14
Cardiac sarcoidosis: An important niche for PET, but a journey just begun. ( 27506701 )
2016
15
FDG PET/CT Evidence of Effective Treatment of Cardiac Sarcoidosis With Adalimumab. ( 26828145 )
2016
16
Electron Microscopy of Contact Between a Monocyte and a Multinucleated Giant Cell in Cardiac Sarcoidosis. ( 27133542 )
2016
17
Seeing Beyond the Obvious: Subclinical Cardiac Sarcoidosis Revealed by Cardiovascular Magnetic Resonance Mapping. ( 27903542 )
2016
18
Regional myocardial damage and active inflammation in patients with cardiac sarcoidosis detected by non-invasive multi-modal imaging. ( 27804054 )
2016
19
Diagnosis, therapeutic response assessment, and detection of disease recurrence in cardiac sarcoidosis: Integral role of cardiac PET. ( 26809438 )
2016
20
Time Course and Factors Correlating With Ventricular Tachyarrhythmias After Introduction of Steroid Therapy in Cardiac Sarcoidosis. ( 27301264 )
2016
21
Cardiac Sarcoidosis and Arrhythmogenic Right Ventricular Cardiomyopathy -Potential Differential Diagnoses for Arrhythmogenic Ventricular Cardiomyopathy. ( 27150851 )
2016
22
Magnetic resonance imaging of cardiac sarcoidosis: an evaluation of the cardiac segments and layers that exhibit late gadolinium enhancement. ( 28008199 )
2016
23
Image fusion between 18F-FDG PET and MRI inA cardiac sarcoidosis: A case series. ( 27604109 )
2016
24
Prevalence of cardiac sarcoidosis in white population: a case-control study: Proposal for a novel risk index based on commonly available tests. ( 27512871 )
2016
25
A Diagnostic and Therapeutic Approach to Arrhythmias in Cardiac Sarcoidosis. ( 26874704 )
2016
26
Fulminant isolated cardiac sarcoidosis with pericardial effusion and acute heart failure: Challenging aspects of diagnosis and treatment. ( 26989672 )
2016
27
Primary Cardiac Sarcoidosis with Syncope and Refractory Atrial Arrhythmia: A Case Report and Review of the Literature. ( 27303240 )
2016
28
Evaluation of Known or Suspected Cardiac Sarcoidosis. ( 26926267 )
2016
29
Long-Term Outcomes of Catheter Ablation of Ventricular Tachycardia in Patients With Cardiac Sarcoidosis. ( 27516457 )
2016
30
Prevention of sudden cardiac death by the wearable cardioverter defibrillator in a young patient with cardiac sarcoidosis. ( 27920335 )
2016
31
An oxidative stress biomarker, urinary 8-hydroxy-2'-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis. ( 27043062 )
2016
32
A dual tracer (68)Ga-DOTANOC PET/CT and (18)F-FDG PET/CT pilot study for detection of cardiac sarcoidosis. ( 27316444 )
2016
33
Accurate diagnosis of cardiac sarcoidosis needs a multidisciplinary approach. ( 27828754 )
2016
34
Cardiac sarcoidosis-state of the art review. ( 26885492 )
2016
35
(18)F-fluoromisonidazole (FMISO) PET may have the potential to detect cardiac sarcoidosis. ( 27071998 )
2016
36
Risk stratification for major adverse cardiac events and ventricular tachyarrhythmias by cardiac MRI in patients with cardiac sarcoidosis. ( 27547432 )
2016
37
Prognostic Value of Myocardial Scarring on CMR in Patients With Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis. ( 27450877 )
2016
38
CMR imaging for follow up of isolated cardiac sarcoidosis with extensive biventricular involvement. ( 27428321 )
2016
39
The response of FDG uptake to immunosuppressive treatment on FDG PET/CT imaging for cardiac sarcoidosis. ( 27457527 )
2016
40
Diagnostic value of speckle-tracking echocardiography in confirmed cardiac sarcoidosis. ( 27270760 )
2016
41
Isolated cardiac sarcoidosis: A focused review of an under-recognized entity. ( 27613395 )
2016
42
Outcome of Patients With Cardiac Sarcoidosis Who Received Cardiac Resynchronization Therapy: Comparison With Dilated Cardiomyopathy Patients. ( 27862596 )
2016
43
Cardiac sarcoidosis: a diagnostic puzzle. ( 27828751 )
2016
44
Diagnosed late cardiac sarcoidosis in a patient with atrioventricular block. ( 27828755 )
2016
45
Myocardial Immunocompetent Cells and Macrophage Phenotypes asA Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese. ( 27856486 )
2016
46
T wave amplitude in lead aVR as a novel diagnostic marker for cardiac sarcoidosis. ( 27465594 )
2016
47
Magnetic Resonance Imaging as a Predictor of Survival Free of Life-Threatening Arrhythmias and Transplantation in Cardiac Sarcoidosis. ( 27139734 )
2016
48
Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction. ( 27867531 )
2016
49
Cardiac sarcoidosis. ( 27037900 )
2016
50
F-18 sodium fluoride PET/CT does not effectively image myocardial inflammation due to suspected cardiac sarcoidosis. ( 27197820 )
2016

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

Pathways related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 IL1B IL5 LGALS3 PSMB8 PSMB9 TAP2
2
Show member pathways
13.29 IL1B IL5 PSMB8 PSMB9 TNF
3
Show member pathways
13.03 IL1B IL5 PSMB8 PSMB9 TNF
4
Show member pathways
12.54 IL1B IL5 TAP2 TNF
5
Show member pathways
12.25 PSMB8 PSMB9 TAP2
6
Show member pathways
12.2 IL1B PSMB8 PSMB9
7
Show member pathways
12.19 IL1B IL5 TNF
8
Show member pathways
12.07 IL1B IL5 TNF
9
Show member pathways
12.01 PSMB8 PSMB9 TNF
10 11.69 IL1B LGALS3 TNF
11 11.57 IL1B IL5 TNF
12 11.52 IL1B LGALS3 PSMB8 TAP2 TNF
13
Show member pathways
11.47 IL1B IL5 PSMB8 TNF
14 11.45 IL1B IL5 TNF
15 11.34 IL1B TNF
16 11.34 IL1B TNF
17 11.33 IL1B TNF
18 11.32 IL1B IL5
19 11.32 IL1B TNF
20 11.3 IL1B IL5 TNF
21 11.29 IL1B TNF
22
Show member pathways
11.26 IL1B TNF
23 11.21 LGALS3 TNC
24 11.17 IL1B PSMB9
25 11.14 IL1B TNF
26 11.13 IL1B TNF
27 11.06 IL1B TNF
28 10.95 IL1B IL5 TNF
29 10.94 IL1B IL5 TNF
30 10.85 IL1B TNF
31 10.81 IL1B IL5 TNF
32 10.68 IL1B TNF
33 10.63 IL1B IL5

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 IL1B IL5 LGALS3 TNC TNF
2 proteasome core complex GO:0005839 8.96 PSMB8 PSMB9
3 spermatoproteasome complex GO:1990111 8.62 PSMB8 PSMB9

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.83 LGALS3 PSMB8 PSMB9 TAP2
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.69 PSMB8 PSMB9 TNF
3 positive regulation of interferon-gamma production GO:0032729 9.62 IL1B TNF
4 positive regulation of interleukin-6 production GO:0032755 9.62 IL1B TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 IL1B TNF
6 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.61 IL1B TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.61 IL1B IL5 TNF
8 protein kinase B signaling GO:0043491 9.6 IL1B TNF
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.59 IL1B TNF
10 positive regulation of phagocytosis GO:0050766 9.58 IL1B TNF
11 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TNF
12 positive regulation of NF-kappaB import into nucleus GO:0042346 9.57 IL1B TNF
13 negative regulation of lipid catabolic process GO:0050995 9.56 IL1B TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IL1B TNF
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.54 IL1B TNF
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.54 PSMB8 PSMB9 TAP2
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL1B TNF
18 positive regulation of podosome assembly GO:0071803 9.48 IL5 TNF
19 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.4 IL1B TNF
21 positive regulation of fever generation GO:0031622 9.32 IL1B TNF
22 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
23 positive regulation of mononuclear cell migration GO:0071677 9.16 LGALS3 TNF
24 MAPK cascade GO:0000165 9.02 IL1B IL5 PSMB8 PSMB9 TNF
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL5 TNF
2 threonine-type endopeptidase activity GO:0004298 8.62 PSMB8 PSMB9

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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