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Cardiac Sarcoidosis malady
18 genes, 6 tissues, 174 related diseases, clinical trials.

Summaries for Cardiac Sarcoidosis

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32MalaCards
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MalaCards: Cardiac Sarcoidosis is related to sarcoidosis and myocarditis. An important gene associated with Cardiac Sarcoidosis is AURKC (aurora kinase C), and among its related pathways are Cytokines and Inflammatory Response and Interleukin-1 processing. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Cardiac Sarcoidosis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

cardiac sarcoidosis 8 60


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Disease Ontology8 DOID:13405
SNOMED-CT56 75403004
NCIt39 C35589

Related Diseases for Cardiac Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.7ACE, TAP2, TAP1, IL1B, IL1A, IL12B
2myocarditis30.4NPPB
3dilated cardiomyopathy30.3NPPB, HLA-DQB1, ACE
4pulmonary sarcoidosis30.1IFNG, TNF, LTA, IL12B, ACE
5myocardial infarction29.9ACE, NPPB
6pulmonary tuberculosis29.9IL12B, HLA-DQB1, IFNG
7coronary artery disease29.9S100A8, NPPB, IL15, ACE
8tuberculosis29.9IFNG, TNF, HLA-DQB1, IL12B, IL1B
9atrioventricular block10.5
10arrhythmogenic right ventricular dysplasia10.3
11hypertrophic cardiomyopathy10.2
12bronchiectasis10.0TAP2
13herpes simplex10.0IL12B
14histiocytosis10.0S100A9
15esophagitis10.0S100A8
16hyperuricemia10.0TAP1
17hepatitis10.0LTA
18panniculitis10.0PSMB8
19duodenitis10.0S100A8
20glioblastoma multiforme10.0LTA
21peptic ulcer10.0S100A8
22pemphigus vulgaris10.0IL1A
23lipodystrophy10.0PSMB8
24silicosis10.0IL1A
25lupus nephritis10.0LTA
26myeloid leukemia10.0LTA
27adenoma10.0S100A8
28dengue hemorrhagic fever10.0LTA
29kawasaki disease10.0NPPB
30chagas disease10.0NPPB
31measles10.0HLA-DMA, IL12B
32hypertriglyceridemia10.0LTA
33crohn's disease10.0TNF
34optic neuritis10.0LTA
35hyperglycemia10.0ACE
36nephrotic syndrome10.0ACE
37deficiency anemia10.0ACE
38connective tissue disease10.0TNF
39myositis10.0IL1A
40cor pulmonale10.0NPPB
41diabetic retinopathy10.0ACE
42urticaria10.0ACE
43osteosarcoma10.0IL1A
44adenocarcinoma10.0S100A9, S100A8
45pulmonary fibrosis10.0IL1B
46colon cancer10.0TAP1, IL15
47pancreatitis10.0IL1B
48glomerulonephritis10.0IL1B
49cerebrovascular disease10.0ACE
50degenerative disc disease10.0IL1B

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to cardiac sarcoidosis

Clinical Features for Cardiac Sarcoidosis

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Drugs & Therapeutics for Cardiac Sarcoidosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cardiac Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Cardiac Sarcoidosis

Search NIH Clinical Center for Cardiac Sarcoidosis

Search CenterWatch for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

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Anatomical Context for Cardiac Sarcoidosis

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32MalaCards
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MalaCards organs/tissues related to Cardiac Sarcoidosis:

32
Heart, Bone, Brain, Myeloid, T cells, Lymph node

Animal Models for Cardiac Sarcoidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
tumorigenesis
MP:00020068.8IFNG, TNF, IL12B, IL1B, TAP1
2
cardiovascular system phenotype
MP:00053857.2TNF, NPPB, HLA-DQB1, LTA, IL15, IL1A
3
cellular phenotype
MP:00053846.2IFNG, S100A9, TNF, HLA-DMA, HLA-DQB1, LTA
4
hematopoietic system phenotype
MP:00053975.9HLA-DMA, PSMB8, TNF, S100A9, IFNG, HLA-DQB1
5
immune system phenotype
MP:00053875.6ACE, IFNG, S100A9, TNF, PSMB8, HLA-DMA
6
mortality/aging
MP:00107685.1HLA-DMA, TNF, S100A8, S100A9, IFNG, HLA-DQB1

Publications for Cardiac Sarcoidosis

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50PubMed
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Articles related to Cardiac Sarcoidosis:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography. (24429936)
2014
2
Cardiac Sarcoidosis: Electrophysiological Outcomes on Long-Term Follow-Up and the Role of the Implantable Cardioverter-Defibrillator. (24433308)
2013
3
Utility of cardiac magnetic resonance in assessing right-sided heart failure in sarcoidosis. (23311586)
2013
4
Clinical utility of a magnetic resonance-conditional pacemaker in a patient with cardiac sarcoidosis. (23774544)
2013
5
Electrophysiologic manifestations of cardiac sarcoidosis. (23880704)
2013
6
Isolated cardiac sarcoidosis: case experience in heart transplantation. (24016616)
2013
7
Correlation of late gadolinium enhancement MRI and quantitative T2 measurement in cardiac sarcoidosis. (23720077)
2013
8
Severe myocardial fibrosis in a patient with cardiac sarcoidosis. (23705573)
2013
9
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia with high defibrillation threshold requiring subcutaneous shocking coil implantation. (21982156)
2012
10
Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (22944174)
2012
11
Arrhythmias in cardiac sarcoidosis: diagnosis and treatment. (22186166)
2012
12
Temporal changes in echocardiographic findings in cardiac and non-cardiac sarcoidosis patients. (23124141)
2012
13
Electrophysiological features of atrial flutter in cardiac sarcoidosis: a report of two cases. (23233762)
2012
14
Serial measurement of high-sensitivity cardiac troponin I and N-terminal proB-type natriuretic peptide in a patient presenting with cardiac sarcoidosis. (23257523)
2012
15
Cardiac Sarcoidosis - Arrhythmias, Inflammation and Anti-inflammatory Drug Therapy. (23233756)
2012
16
Cardiac sarcoidosis mimicking non-ST-elevation myocardial infarction. (20508527)
2012
17
Diagnosis of cardiac sarcoidosis through mismatched defects seen on N-13 NH3/F-18 FDG cardiac PET. (22064101)
2011
18
Prevalence of echocardiographic features suggesting cardiac sarcoidosis in patients with pacemaker or implantable cardiac defibrillator. (21779284)
2011
19
Atrial fibrillation as the initial clinical manifestation of cardiac sarcoidosis: a case report and review of the literature. (21252695)
2011
20
Ventricular tachycardia in cardiac sarcoidosis controlled by radiofrequency catheter ablation. (21628935)
2011
21
Cardiac sarcoidosis: oldies but not goodies. (21779280)
2011
22
Diagnosing cardiac sarcoidosis clinically without tissue confirmation. (19633746)
2009
23
Cardiac sarcoidosis. (19081391)
2009
24
Cardiac sarcoidosis: a case report. (19044177)
2008
25
Case report: Cardiac sarcoidosis presenting with ventricular arrhythmias: case report and review of the literature. (17588690)
2007
26
Usefulness of 67Ga SPECT and integrated low-dose CT scanning (SPECT/CT) in the diagnosis of cardiac sarcoidosis. (18092130)
2007
27
Cardiac sarcoidosis responding to monotherapy with infliximab. (17394036)
2007
28
Elevated plasma brain natriuretic peptide level in cardiac sarcoidosis patients with preserved ejection fraction. (16954683)
2007
29
Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia. (16763884)
2006
30
Right ventricle-dominant cardiac sarcoidosis with sparing of the left ventricle. (16563981)
2006
31
Combination of 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in assessing cardiac sarcoidosis. (16315788)
2005
32
Images in cardiovascular medicine. Follow-up of cardiac sarcoidosis by magnetic resonance imaging. (15781746)
2005
33
Images in cardiovascular medicine. Reversible right ventricular hypertrophy due to cardiac sarcoidosis. (15956140)
2005
34
Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis. (15619415)
2005
35
Effectiveness of delayed enhanced MRI for identification of cardiac sarcoidosis: comparison with radionuclide imaging. (15972409)
2005
36
Ventricular tachycardia with figure eight pattern originating from the right ventricle in a patient with cardiac sarcoidosis. (15078419)
2004
37
Cardiac sarcoidosis: a retrospective study of 41 cases. (15525844)
2004
38
Identification of cardiac sarcoidosis with (13)N-NH(3)/(18)F-FDG PET. (12843216)
2003
39
Matrix metalloproteinases and their tissue inhibitors in the lesions of cardiac and pulmonary sarcoidosis: an immunohistochemical study. (12514782)
2002
40
Cardiac sarcoidosis &hypen; the value of magnetic resonance imaging. (11447482)
2000
41
Successfully treated complete atrioventricular block with corticosteroid in a patient with cardiac sarcoidosis: usefulness of gallium-67 and thallium-201 scintigraphy. (10772129)
2000
42
Genetic polymorphisms at the tumour necrosis factor loci (TNFA and TNFB) in cardiac sarcoidosis. (10488747)
1999
43
A case of cardiac sarcoidosis: significance of ventricular tachycardia originating from the septum. (9652324)
1998
44
Cardiac sarcoidosis--an occult cause of sudden death: a case report and literature review. (9608713)
1998
45
Indium-111-labelled antimyosin antibody imaging in a patient with cardiac sarcoidosis. (8420786)
1993
46
Antiarrhythmic therapy guided by programmed electrical stimulation in cardiac sarcoidosis with ventricular tachycardia. (1990769)
1991
47
Cardiac sarcoidosis: two cases with ventricular tachycardia and review of cardiac involvement in sarcoid. (15226999)
1985
48
Cardiac sarcoidosis. (638574)
1978
49
Development of ventricular aneurysm in cardiac sarcoidosis. (869289)
1977
50
A case of cardiac sarcoidosis manifested uncontrollable ventricular tachycardia. Review of cardiac manifestations in sixteen cases of sarcoidosis. (13983692)
1962

Genetic Variations for Cardiac Sarcoidosis

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Expression for genes affiliated with Cardiac Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for genes affiliated with Cardiac Sarcoidosis

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 52R&D Systems
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Pathways related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cytokines and Inflammatory Response37
10.2IL12B
2
Interleukin-1 processing53
9.8IL1A, IL1B
3
Immune response Antigen presentation by MHC class I12
9.8PSMB8, TAP1, TAP2
4
B cell receptor signaling pathway29
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9.8IFNG, IL1A
5
TGF-Beta Pathway51
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9.7IL12B, LTA, PSMB8
6
PEDF Induced Signaling51
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9.7IL1A, IL15
7
Type II interferon signaling (IFNG)37
9.5TAP1, IL1B, IFNG
8
Transcription NF-kB signaling pathway12
9.5IL1A, LTA, TNF
9
Immune response IL-12-induced IFN-gamma production12
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9.5IL1B, IL12B, IFNG
10
PAK Pathway51
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9.4LTA, IL15, IL12B
11
Rheumatoid arthritis29
9.4HLA-DMA, IL15
12
Immune response IL-22 signaling pathway12
9.4HLA-DMA, HLA-DQB1, IL12B
13
Salmonella infection29
9.4IFNG, IL1A, IL1B
14
Legionellosis29
9.4TNF, IL12B, IL1B
15
NF-kappa B signaling pathway29
9.4IL1B, LTA, TNF
16
Hematopoietic cell lineage29
9.4TNF, IL1A, IL1B
17
IL-10 Pathway51
9.4TNF, IL1A, IL1B
18
Spinal Cord Injury37
9.4IL1B, IL1A, TNF
19
RIP-mediated NFkB activation via ZBP153
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9.3IFNG, TNF, LTA
20
Rho Family GTPases51
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9.2AURKC, LTA, IL15, IL12B
21
Selenium Pathway37
9.2IFNG, TNF, IL1B
22
Phagosome29
9.2TAP2, TAP1, HLA-DQB1, HLA-DMA
23
HTLV-I infection29
9.1IL15, HLA-DQB1, HLA-DMA
24
Leishmaniasis29
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9.1IL1A, IL12B, HLA-DQB1, HLA-DMA
25
Pertussis29
9.1TNF, IL12B, IL1A, IL1B
26
14-3-3 Induced Apoptosis51
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9.1TNF, LTA, IL1A, IL1B
27
NF-KappaB Family Pathway51
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9.1IL1B, IL1A, LTA, TNF
28
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types52
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9.1IFNG, TNF, IL15
29
Amoebiasis29
9.0IL1B, IL12B, TNF, IFNG
30
Development PDGF signaling via STATs and NF-kB
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9.0IL1B, IL12B, TNF, IFNG
31
MSP-RON Signaling51
9.0IL1B, IL12B, TNF, IFNG
32
African trypanosomiasis29
9.0IFNG, TNF, IL12B, IL1B
33
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0IFNG, TNF, IL1A, IL1B
34
Osteoclast differentiation29
9.0IFNG, TNF, IL1A, IL1B
35
Immune response Bacterial infections in normal airways
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9.0IFNG, TNF, IL1A, IL1B
36
Toll Comparative Pathway51
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9.0IFNG, TNF, IL1A, IL1B
37
CDK-mediated phosphorylation and removal of Cdc653
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8.9TAP2, TAP1, PSMB8, TNF, IFNG
38
Interferon Signaling53
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8.9IFNG, PSMB8, HLA-DQB1, IL1A, IL1B
39
TNF signaling pathway29
8.9TNF, LTA, IL15, IL1B
40
TRAF Pathway51
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8.9TNF, LTA, IL12B, IL1A, IL1B
41
Alcoholism29
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8.8HLA-DQB1, HLA-DMA, TNF, IFNG
42
IL27-mediated signaling events37
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8.7IFNG, TNF, LTA, IL12B, IL1B
43
Tuberculosis29
8.7TNF, HLA-DMA, HLA-DQB1, IL12B, IL1A
44
Toll-like receptor signaling pathway37
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8.6ACE, IL1B, IL12B, TNF, IFNG
45
Akt Signaling51
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8.3TNF, LTA, IL15, IL12B, IL1A, IL1B
46
ErbB4 Pathway51
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8.1IFNG, TNF, HLA-DMA, HLA-DQB1, IL1A, IL1B
47
Immune System53
Hide members
7.9IFNG, PSMB8, HLA-DMA, HLA-DQB1, IL1A, IL1B
48
Cytokine Network51
7.9IFNG, TNF, LTA, IL15, IL12B, IL1A
49
Allograft rejection29
Hide members
7.1IFNG, TNF, HLA-DMA, HLA-DQB1, LTA, IL15
50
Influenza A29
Hide members
6.7TAP2, IFNG, TNF, HLA-DMA, TAP1, IL1B

Compounds for genes affiliated with Cardiac Sarcoidosis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6LTA
2indomethacin44 59 28 1113.5NPPB
3tenidap44 2811.5IL1A
4pentoxifylline44 1111.1NPPB, LTA, IL12B
5gm-csf44 2811.0TNF, IFNG
6fmlp449.8IL1A, S100A9
7lipoteichoic acid449.5TNF, LTA, IL12B, IL1B
8endotoxin449.5S100A8, S100A9
9sulfasalazine44 28 49 1112.5TNF, IL12B, IL1A, IL1B
10p005449.5S100A8, IL15
11imiquimod44 28 59 1112.5IFNG, TNF, IL12B, IL1A
12taurine chloramine449.4IFNG, TNF, IL1B
13vesnarinone449.4IFNG, TNF, IL1B
14gold sodium thiomalate449.4IL1B, IL1A, TNF, IFNG
15polymyxin b449.3IL1B, IL1A, TNF, IFNG
16toxin-1449.3TNF, LTA, IL1B
17l-nmma449.2IFNG, TNF, NPPB, IL1B
18okt3449.2IFNG, TNF, LTA, IL15
19peptidoglycan44 2810.1TNF, IL15, IL12B, IL1B
20ivig449.1IFNG, TNF, LTA, IL1A, IL1B
21neopterin449.1IFNG, TNF, LTA, IL1A, IL1B
22herbimycin a44 5910.0IFNG, TNF, LTA, IL1A, IL1B
23dexamethasone44 49 28 1112.0IL15, LTA, NPPB, S100A8
24cyclosporin a44 28 5911.0IL15, LTA, NPPB, IFNG
25monosodium urate448.9S100A9, S100A8, IL1B
26il-12448.9IFNG, TNF, IL15, IL12B, IL1B
27prostacyclin448.9TNF, NPPB, IL1A, IL1B, ACE
28poly(i-c)448.9IFNG, TNF, IL15, IL12B, IL1B
29etanercept44 49 1110.9IFNG, TNF, LTA, IL15, IL1B
30infliximab44 49 1110.9IFNG, TNF, LTA, IL15, IL1B
31ccl344 289.8IFNG, TNF, IL15, IL1A, IL1B
32pirfenidone44 599.8S100A9, S100A8, IL1A, IL1B
33ionomycin448.8IL1A, IL15, LTA, TNF, IFNG
344-ipp598.8S100A9, S100A8, IL1A, IL1B
35git 27598.8S100A9, S100A8, IL1A, IL1B
36as 10159 449.8IL1B, IL1A, S100A8, S100A9
37sb 20358044 599.8IFNG, TNF, NPPB, IL12B, IL1A, IL1B
38actinomycin d448.7IFNG, TNF, NPPB, LTA, IL1A, IL1B
39polyinosinic-polycytidylic acid448.6IFNG, TNF, IL15, IL12B, IL1A, IL1B
40il 10448.4IL1B, IL1A, IL12B, IL15, LTA, TNF
41thalidomide44 49 59 1110.9IFNG, S100A9, S100A8, TNF, IL1A, IL1B
42histamine44 28 249.9IFNG, S100A8, TNF, NPPB, IL15, IL1B
43vegf447.8TNF, NPPB, LTA, IL15, IL1A, IL1B
44arachidonic acid44 28 11 2410.8S100A9, S100A8, TNF, LTA, IL1A, IL1B
45calcitriol44 59 11 2410.7IFNG, S100A9, S100A8, TNF, LTA, IL1A
46oligonucleotide447.7S100A8, HLA-DMA, HLA-DQB1, LTA, IL15, TAP1
47rantes447.5IFNG, S100A8, TNF, LTA, IL15, IL12B
48methotrexate44 49 119.4IL1B, IL15, TNF, S100A8, S100A9
49retinoic acid44 248.0IFNG, S100A9, S100A8, TNF, LTA, IL15
50nitric oxide44 11 248.3IFNG, S100A9, S100A8, TNF, NPPB, LTA

GO Terms for genes affiliated with Cardiac Sarcoidosis

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Sources:
16Gene Ontology
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Cellular components related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.7TAP1, TAP2
2external side of plasma membraneGO:0098979.0SEMA7A, ACE, TNF, IFNG
3extracellular regionGO:0055766.2IFNG, S100A9, S100A8, TNF, NPPB, IL15
4extracellular spaceGO:0056155.8ACE, IFNG, S100A9, S100A8, TNF, NPPB

Biological processes related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.4TAP1, TAP2
2intracellular transport of viral proteins in host cellGO:01906010.4TAP2, TAP1
3peptide transportGO:01583310.3TAP1, TAP2
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.2TAP1, TAP2
5positive regulation of T cell mediated cytotoxicityGO:00191610.2IL12B, TAP1, TAP2
6fever generationGO:00166010.2IL1A, IL1B
7positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL12B, IL1B
8positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.1TNF, LTA
9positive regulation of smooth muscle cell apoptotic processGO:03439310.0IFNG, IL12B
10positive regulation of natural killer cell proliferationGO:03281910.0IL12B, IL15
11positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0LTA, TNF
12positive regulation of tissue remodelingGO:03410510.0IL12B, IL15
13positive regulation of vitamin D biosynthetic processGO:06055710.0TNF, IFNG
14sequestering of triglycerideGO:03073010.0IL1B, TNF
15negative regulation of interleukin-17 productionGO:03270010.0IL12B, IFNG
16positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
17positive regulation of fever generationGO:03162210.0IL1B, TNF
18positive regulation of interleukin-6 biosynthetic processGO:0454109.9IFNG, IL1B
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.9TAP2, TAP1, PSMB8
20positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, IL12B, TNF
21positive regulation of osteoclast differentiationGO:0456729.8IL12B, TNF, IFNG
22negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8TNF, IL1A, IL1B
23positive regulation of mitosisGO:0458409.8IL1B, IL1A, TNF
24negative regulation of smooth muscle cell proliferationGO:0486629.7IL12B, IL15, IFNG
25antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.7PSMB8, TAP1, TAP2
26humoral immune responseGO:0069599.7LTA, TNF, IFNG
27positive regulation of immune responseGO:0507789.7HLA-DMA, IL15
28positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IL1B, TNF, IFNG
29positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, TNF, IFNG
30positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF, IL1B
31regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.6IL1B, TNF
32positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF, IL1B
33positive regulation of interferon-gamma productionGO:0327299.6TNF, LTA, IL12B, IL1B
34negative regulation of growth of symbiont in hostGO:0441309.6IL12B, LTA, TNF, IFNG
35neutrophil aggregationGO:0704889.4S100A8, S100A9
36chemokine productionGO:0326029.4S100A9, S100A8
37sequestering of zinc ionGO:0321199.4S100A9, S100A8
38positive regulation of T cell proliferationGO:0421029.4IFNG, IL15, IL12B, IL1B
39cytokine-mediated signaling pathwayGO:0192219.3IFNG, PSMB8, HLA-DQB1, IL1A, IL1B
40leukocyte migration involved in inflammatory responseGO:0025239.3S100A8, S100A9
41regulation of insulin secretionGO:0507969.2IFNG, TNF, IL1B
42immune responseGO:0069559.1HLA-DQB1, IL15, IL1A, IL1B, SEMA7A
43chronic inflammatory responseGO:0025449.1S100A9, S100A8
44cell-cell signalingGO:0072678.8S100A9, LTA, IL15, IL1B
45apoptotic processGO:0069158.8IL1B, IL1A, LTA, PSMB8, TNF, IFNG
46positive regulation of inflammatory responseGO:0507298.7S100A9, S100A8, IL15, IL12B
47neutrophil chemotaxisGO:0305938.7IL1B, S100A8, S100A9, IFNG
48positive regulation of NF-kappaB transcription factor activityGO:0510928.6S100A9, S100A8, TNF, IL1B
49activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.3S100A9, S100A8, TNF
50inflammatory responseGO:0069547.6S100A9, S100A8, TNF, IL15, IL1A, IL1B

Molecular functions related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.3TAP1, TAP2
2peptide transporter activityGO:01519710.2TAP1, TAP2
3TAP2 bindingGO:04697910.2TAP1, TAP2
4TAP1 bindingGO:04697810.2TAP1, TAP2
5oligopeptide-transporting ATPase activityGO:01542110.1TAP1, TAP2
6MHC class I protein bindingGO:04228810.0TAP2, TAP1
7interleukin-1 receptor bindingGO:0051499.5IL1B, IL1A
8Toll-like receptor 4 bindingGO:0356629.1S100A9, S100A8
9arachidonic acid bindingGO:0505449.0S100A8, S100A9
10RAGE receptor bindingGO:0507868.9S100A9, S100A8
11cytokine activityGO:0051258.2IL1B, IL1A, IL12B, IL15, LTA, TNF

Products for genes affiliated with Cardiac Sarcoidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiac Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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