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MCID: CRD003
MIFTS: 46

Cardiac Sarcoidosis malady
18 genes, 6 tissues, 176 related diseases, clinical trials.

Summaries for Cardiac Sarcoidosis

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33MalaCards
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MalaCards: Cardiac Sarcoidosis is related to pulmonary sarcoidosis and coronary heart disease. An important gene associated with Cardiac Sarcoidosis is AURKC (aurora kinase C), and among its related pathways are Cytokines and Inflammatory Response and Interleukin-1 processing. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and heart, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Cardiac Sarcoidosis

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8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

cardiac sarcoidosis 8 61


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Disease Ontology8 DOID:13405
SNOMED-CT57 75403004
NCIt40 C35589

Related Diseases for Cardiac Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary sarcoidosis30.1IFNG, TNF, LTA, IL12B, ACE
2coronary heart disease29.9NPPB, LTA, ACE
3pulmonary tuberculosis29.9IL12B, HLA-DQB1, IFNG
4coronary artery disease,29.9S100A8, NPPB, IL15, ACE
5tuberculosis29.9IFNG, TNF, HLA-DQB1, IL12B, IL1B
6atrioventricular block10.5
7hypertrophic cardiomyopathy10.2
8giant cell myocarditis10.2
9sarcoidosis 210.1
10choroiditis10.0
11vasculitis10.0
12cardiac rupture10.0
13serpiginous choroiditis10.0
14splenomegaly10.0
15syncope10.0
16bronchiectasis10.0TAP2
17herpes simplex10.0IL12B
18histiocytosis10.0S100A9
19esophagitis10.0S100A8
20hyperuricemia10.0TAP1
21hepatitis10.0LTA
22panniculitis10.0PSMB8
23duodenitis10.0S100A8
24glioblastoma multiforme10.0LTA
25peptic ulcer10.0S100A8
26pemphigus vulgaris10.0IL1A
27lipodystrophy10.0PSMB8
28silicosis10.0IL1A
29lupus nephritis10.0LTA
30myeloid leukemia10.0LTA
31adenoma10.0S100A8
32dengue hemorrhagic fever10.0LTA
33kawasaki disease10.0NPPB
34chagas disease10.0NPPB
35measles10.0HLA-DMA, IL12B
36hypertriglyceridemia10.0LTA
37myocarditis10.0NPPB
38crohn's disease10.0TNF
39optic neuritis10.0LTA
40hyperglycemia10.0ACE
41nephrotic syndrome10.0ACE
42deficiency anemia10.0ACE
43connective tissue disease10.0TNF
44myositis10.0IL1A
45cor pulmonale10.0NPPB
46diabetic retinopathy10.0ACE
47urticaria10.0ACE
48osteosarcoma10.0IL1A
49adenocarcinoma10.0S100A9, S100A8
50pulmonary fibrosis10.0IL1B

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to cardiac sarcoidosis

Clinical Features for Cardiac Sarcoidosis

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Drugs & Therapeutics for Cardiac Sarcoidosis

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cardiac Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Cardiac Sarcoidosis

Search NIH Clinical Center for Cardiac Sarcoidosis

Search CenterWatch for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

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Anatomical Context for Cardiac Sarcoidosis

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33MalaCards
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MalaCards organs/tissues related to Cardiac Sarcoidosis:

33
Lymph node, Brain, Heart, Myeloid, T cells, Atrioventricular node

Animal Models for Cardiac Sarcoidosis or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
tumorigenesis
MP:00020068.8IFNG, TNF, IL12B, IL1B, TAP1
2
cardiovascular system phenotype
MP:00053857.2TNF, NPPB, HLA-DQB1, LTA, IL15, IL1A
3
cellular phenotype
MP:00053846.2IFNG, S100A9, TNF, HLA-DMA, HLA-DQB1, LTA
4
hematopoietic system phenotype
MP:00053975.9HLA-DMA, PSMB8, TNF, S100A9, IFNG, HLA-DQB1
5
immune system phenotype
MP:00053875.6ACE, IFNG, S100A9, TNF, PSMB8, HLA-DMA
6
mortality/aging
MP:00107685.1HLA-DMA, TNF, S100A8, S100A9, IFNG, HLA-DQB1

Publications for Cardiac Sarcoidosis

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51PubMed
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Articles related to Cardiac Sarcoidosis:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
The difficult diagnosis of isolated cardiac sarcoidosis: usefulness of an integrated MRI and PET approach. (23838000)
2014
2
Inactive cardiac sarcoidosis with characteristic findings on cardiac MRI. (24177462)
2013
3
Cardiac Positron Emission Tomography Enhances Prognostic Assessments of Patients with Suspected Cardiac Sarcoidosis. (24140661)
2013
4
Morphologic Features of Cardiac Sarcoidosis in Native Hearts of Patients Having Cardiac Transplantation. (24393258)
2013
5
Diagnosis of right ventricular cardiac sarcoidosis with cardiac magnetic resonance in a patient presenting with ventricular tachycardia. (23764336)
2013
6
Use of multimodality imaging to diagnose cardiac sarcoidosis as well as identify recurrence following heart transplantation. (23361861)
2013
7
Heart transplantation for end-stage heart failure due to cardiac sarcoidosis. (23953552)
2013
8
Capability of three-dimensional speckle tracking radial strain for identification of patients with cardiac sarcoidosis. (22850930)
2013
9
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
10
Diagnosis and monitoring of cardiac sarcoidosis with delayed-enhanced MRI and 18F-FDG PET-CT. (22466988)
2012
11
Interventricular septal mass in a patient with cardiac sarcoidosis. (22082075)
2012
12
Outcome of patients with cardiac sarcoidosis undergoing cardiac transplantation--single-center retrospective analysis. (22890069)
2012
13
Cardiac sarcoidosis presenting as an arrhythmogenic right ventricular cardiomyopathy. (22942296)
2012
14
Cardiac sarcoidosis with a rare initial manifestation: sustained monomorphic ventricular tachycardia. (21423476)
2011
15
Cardiac sarcoidosis: a review 2011. (21743332)
2011
16
Diagnostic utility of signal-averaged electrocardiography for detection of cardiac sarcoidosis. (21251137)
2011
17
Cardiac sarcoidosis evaluated by multimodality imaging. (20061038)
2011
18
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
19
Cardiac sarcoidosis: a pathology-focused review. (20586635)
2010
20
Second left ventricular aneurysm newly developed in a patient with untreated cardiac sarcoidosis. (20890051)
2010
21
Isolated primary cardiac sarcoidosis: MRI diagnosis and monitoring of treatment response with cardiac enzymes. (21081735)
2010
22
Severe ventricular arrhythmias in a patient with cardiac sarcoidosis: insights from MRI and PET imaging and importance of early corticosteroid therapy. (19854726)
2010
23
Left bundle branch block-type ventricular tachycardia originating from the left ventricular septum in a patient with cardiac sarcoidosis. (19621252)
2009
24
Cardiac sarcoidosis culminating in severe biventricular failure. (19746177)
2009
25
Cardiac sarcoidosis imitating arrhythmogenic right ventricular dysplasia. (18695196)
2008
26
Cardiac sarcoidosis concealed by arrhythmogenic right ventricular dysplasia/cardiomyopathy. (18301387)
2008
27
Usefulness of late gadolinium enhancement combined with MRI and 67-Ga scintigraphy in the diagnosis of cardiac sarcoidosis and disease activity evaluation. (16868855)
2007
28
Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis. (17895549)
2007
29
Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)
2007
30
Aortic saddle embolism caused by left ventricular thrombus in a patient with cardiac sarcoidosis. (17268134)
2007
31
Cardiac sarcoidosis presenting as mitral regurgitation. (17617323)
2007
32
Utility of endomyocardial biopsy guided by delayed enhancement areas on magnetic resonance imaging in the diagnosis of cardiac sarcoidosis. (17694383)
2007
33
Images in cardiovascular medicine. Multimodality imaging of cardiac sarcoidosis before and after steroid therapy. (16717157)
2006
34
Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis. (15881282)
2005
35
Usefulness of dual 67Ga and 99mTc-sestamibi single-photon-emission CT scanning in the diagnosis of cardiac sarcoidosis. (15486407)
2004
36
Images in cardiovascular medicine. Cardiac sarcoidosis evaluated by delayed-enhanced magnetic resonance imaging. (12777322)
2003
37
Cardiac sarcoidosis: cytokine patterns in the course of the disease. (12946220)
2003
38
Cardiac sarcoidosis: an elusive diagnosis. (16352118)
2003
39
Diagnosis of cardiac sarcoidosis: an imperfect science, a hesitant art. (12527597)
2003
40
Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. (11577764)
2001
41
Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. (11703997)
2001
42
Heart failure as a cardiac symptom of sarcoidosis. Successful treatment of heart failure with steroids, digitalis and an angiotensin-1-receptor antagonist in sarcoidosis]. (10771561)
2000
43
Cardiac sarcoidosis: diagnostic, prognostic, and therapeutic considerations. (8950063)
1996
44
Diagnosis of cardiac sarcoidosis aided by MRI. (8697868)
1996
45
Cardiac sarcoidosis. An unusual form of acute congestive cardiomyopathy. (7580367)
1995
46
Cardiac sarcoidosis: a new approach to treatment. (8049989)
1994
47
Cardiac sarcoidosis. (1669983)
1991
48
Cardiac sarcoidosis: two cases with ventricular tachycardia and review of cardiac involvement in sarcoid. (15227374)
1986
49
Cardiac sarcoidosis: reversion of myocardial perfusion abnormalities by dipyridamole. (4076228)
1985
50
Cardiac sarcoidosis. (6639253)
1983

Genetic Variations for Cardiac Sarcoidosis

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Expression for genes affiliated with Cardiac Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for genes affiliated with Cardiac Sarcoidosis

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38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG, 52QIAGEN, 53R&D Systems
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Pathways related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cytokines and Inflammatory Response38
10.2IL12B
2
Interleukin-1 processing54
9.8IL1A, IL1B
3
Immune response Antigen presentation by MHC class I12
9.8PSMB8, TAP1, TAP2
4
B cell receptor signaling pathway30
Hide members
9.8IFNG, IL1A
5
TGF-Beta Pathway52
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9.7IL12B, LTA, PSMB8
6
PEDF Induced Signaling52
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9.7IL1A, IL15
7
Type II interferon signaling (IFNG)38
9.5TAP1, IL1B, IFNG
8
Transcription NF-kB signaling pathway12
9.5IL1A, LTA, TNF
9
Immune response IL-12-induced IFN-gamma production12
Hide members
9.5IL1B, IL12B, IFNG
10
PAK Pathway52
Hide members
9.4LTA, IL15, IL12B
11
Rheumatoid arthritis30
9.4HLA-DMA, IL15
12
Immune response IL-22 signaling pathway12
9.4HLA-DMA, HLA-DQB1, IL12B
13
Salmonella infection30
9.4IFNG, IL1A, IL1B
14
Legionellosis30
9.4TNF, IL12B, IL1B
15
NF-kappa B signaling pathway30
9.4IL1B, LTA, TNF
16
Hematopoietic cell lineage30
9.4TNF, IL1A, IL1B
17
IL-10 Pathway52
9.4TNF, IL1A, IL1B
18
Spinal Cord Injury38
9.4IL1B, IL1A, TNF
19
RIP-mediated NFkB activation via ZBP154
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9.3IFNG, TNF, LTA
20
Rho Family GTPases52
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9.2AURKC, LTA, IL15, IL12B
21
Selenium Pathway38
9.2IFNG, TNF, IL1B
22
Phagosome30
9.2TAP2, TAP1, HLA-DQB1, HLA-DMA
23
HTLV-I infection30
9.1IL15, HLA-DQB1, HLA-DMA
24
Leishmaniasis30
Hide members
9.1IL1A, IL12B, HLA-DQB1, HLA-DMA
25
Pertussis30
9.1TNF, IL12B, IL1A, IL1B
26
14-3-3 Induced Apoptosis52
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9.1TNF, LTA, IL1A, IL1B
27
NF-KappaB Family Pathway52
Hide members
9.1IL1B, IL1A, LTA, TNF
28
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types53
Hide members
9.1IFNG, TNF, IL15
29
Amoebiasis30
9.0IL1B, IL12B, TNF, IFNG
30
Development PDGF signaling via STATs and NF-kB
Hide members
9.0IL1B, IL12B, TNF, IFNG
31
MSP-RON Signaling52
9.0IL1B, IL12B, TNF, IFNG
32
African trypanosomiasis30
9.0IFNG, TNF, IL12B, IL1B
33
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0IFNG, TNF, IL1A, IL1B
34
Osteoclast differentiation30
9.0IFNG, TNF, IL1A, IL1B
35
Immune response Bacterial infections in normal airways
Hide members
9.0IFNG, TNF, IL1A, IL1B
36
Toll Comparative Pathway52
Hide members
9.0IFNG, TNF, IL1A, IL1B
37
CDK-mediated phosphorylation and removal of Cdc654
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8.9TAP2, TAP1, PSMB8, TNF, IFNG
38
Interferon Signaling54
Hide members
8.9IFNG, PSMB8, HLA-DQB1, IL1A, IL1B
39
TNF signaling pathway30
8.9TNF, LTA, IL15, IL1B
40
TRAF Pathway52
Hide members
8.9TNF, LTA, IL12B, IL1A, IL1B
41
Alcoholism30
Hide members
8.8HLA-DQB1, HLA-DMA, TNF, IFNG
42
IL27-mediated signaling events38
Hide members
8.7IFNG, TNF, LTA, IL12B, IL1B
43
Tuberculosis30
8.7TNF, HLA-DMA, HLA-DQB1, IL12B, IL1A
44
Toll-like receptor signaling pathway38
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8.6ACE, IL1B, IL12B, TNF, IFNG
45
Akt Signaling52
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8.3TNF, LTA, IL15, IL12B, IL1A, IL1B
46
ErbB4 Pathway52
Hide members
8.1IFNG, TNF, HLA-DMA, HLA-DQB1, IL1A, IL1B
47
Immune System54
Hide members
7.9IFNG, PSMB8, HLA-DMA, HLA-DQB1, IL1A, IL1B
48
Cytokine Network52
7.9IFNG, TNF, LTA, IL15, IL12B, IL1A
49
Allograft rejection30
Hide members
7.1IFNG, TNF, HLA-DMA, HLA-DQB1, LTA, IL15
50
Influenza A30
Hide members
6.7TAP2, IFNG, TNF, HLA-DMA, TAP1, IL1B

Compounds for genes affiliated with Cardiac Sarcoidosis

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Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6LTA
2indomethacin45 60 29 1113.5NPPB
3tenidap45 2911.5IL1A
4pentoxifylline45 1111.1IL12B, NPPB, LTA
5gm-csf45 2911.0TNF, IFNG
6fmlp459.8S100A9, IL1A
7lipoteichoic acid459.5IL1B, IL12B, LTA, TNF
8endotoxin459.5S100A8, S100A9
9sulfasalazine45 29 50 1112.5IL1B, IL12B, IL1A, TNF
10p005459.5IL15, S100A8
11imiquimod45 29 60 1112.5IL12B, IL1A, TNF, IFNG
12taurine chloramine459.4IL1B, TNF, IFNG
13vesnarinone459.4IFNG, TNF, IL1B
14gold sodium thiomalate459.4IFNG, TNF, IL1A, IL1B
15polymyxin b459.3TNF, IFNG, IL1A, IL1B
16toxin-1459.3IL1B, LTA, TNF
17l-nmma459.2IL1B, IFNG, NPPB, TNF
18okt3459.2TNF, IFNG, LTA, IL15
19peptidoglycan45 2910.1IL1B, IL15, TNF, IL12B
20ivig459.1LTA, IL1B, IFNG, IL1A, TNF
21neopterin459.1IFNG, LTA, IL1A, IL1B, TNF
22herbimycin a45 6010.0IL1A, IFNG, TNF, LTA, IL1B
23dexamethasone45 50 29 1112.0LTA, IL15, S100A8, NPPB
24cyclosporin a45 29 6011.0IL15, NPPB, IFNG, LTA
25monosodium urate458.9IL1B, S100A9, S100A8
26il-12458.9IL15, IL1B, TNF, IFNG, IL12B
27prostacyclin458.9TNF, IL1A, NPPB, ACE, IL1B
28poly(i-c)458.9IL12B, IL1B, IFNG, TNF, IL15
29etanercept45 50 1110.9IL15, LTA, TNF, IL1B, IFNG
30infliximab45 50 1110.9IL15, IFNG, TNF, IL1B, LTA
31ccl345 299.8IL15, IL1B, IL1A, IFNG, TNF
32pirfenidone45 609.8S100A8, S100A9, IL1B, IL1A
33ionomycin458.8IL15, IL1A, IFNG, TNF, LTA
344-ipp608.8IL1B, IL1A, S100A8, S100A9
35git 27608.8S100A9, IL1A, S100A8, IL1B
36as 10160 459.8S100A9, S100A8, IL1A, IL1B
37sb 20358045 609.8IL1B, IL12B, NPPB, TNF, IL1A, IFNG
38actinomycin d458.7IL1A, IFNG, IL1B, LTA, NPPB, TNF
39polyinosinic-polycytidylic acid458.6IL15, IL12B, IL1A, IL1B, TNF, IFNG
40il 10458.4IL1A, IL15, IL1B, IL12B, LTA, TNF
41thalidomide45 50 60 1110.9IL1A, IFNG, IL1B, TNF, S100A9, S100A8
42histamine45 29 249.9NPPB, TNF, S100A8, IFNG, IL15, IL1B
43vegf457.8IL1B, IL15, LTA, NPPB, TNF, IFNG
44arachidonic acid45 29 11 2410.8IL1A, LTA, TNF, S100A9, S100A8, IL1B
45calcitriol45 60 11 2410.7S100A9, IFNG, S100A8, TNF, IL1B, IL1A
46oligonucleotide457.7S100A8, HLA-DMA, HLA-DQB1, LTA, IL15, TAP1
47rantes457.5IL12B, LTA, S100A8, TNF, IL15, IL1A
48methotrexate45 50 119.4S100A9, IL15, IL1B, TNF, S100A8
49retinoic acid45 248.0LTA, IL15, S100A8, TNF, S100A9, IL1A
50nitric oxide45 11 248.3LTA, S100A9, TNF, NPPB, IL12B, IFNG

GO Terms for genes affiliated with Cardiac Sarcoidosis

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Sources:
16Gene Ontology
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Cellular components related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.7TAP1, TAP2
2external side of plasma membraneGO:0098979.0SEMA7A, ACE, TNF, IFNG
3extracellular regionGO:0055766.2IFNG, S100A9, S100A8, TNF, NPPB, IL15
4extracellular spaceGO:0056155.8ACE, IFNG, S100A9, S100A8, TNF, NPPB

Biological processes related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.4TAP1, TAP2
2intracellular transport of viral proteins in host cellGO:01906010.4TAP2, TAP1
3peptide transportGO:01583310.3TAP1, TAP2
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.2TAP1, TAP2
5positive regulation of T cell mediated cytotoxicityGO:00191610.2IL12B, TAP1, TAP2
6fever generationGO:00166010.2IL1A, IL1B
7positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL12B, IL1B
8positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.1TNF, LTA
9positive regulation of smooth muscle cell apoptotic processGO:03439310.0IFNG, IL12B
10positive regulation of natural killer cell proliferationGO:03281910.0IL12B, IL15
11positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0LTA, TNF
12positive regulation of tissue remodelingGO:03410510.0IL12B, IL15
13positive regulation of vitamin D biosynthetic processGO:06055710.0TNF, IFNG
14sequestering of triglycerideGO:03073010.0IL1B, TNF
15negative regulation of interleukin-17 productionGO:03270010.0IL12B, IFNG
16positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
17positive regulation of fever generationGO:03162210.0IL1B, TNF
18positive regulation of interleukin-6 biosynthetic processGO:0454109.9IFNG, IL1B
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.9TAP2, TAP1, PSMB8
20positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, IL12B, TNF
21positive regulation of osteoclast differentiationGO:0456729.8IL12B, TNF, IFNG
22negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8TNF, IL1A, IL1B
23positive regulation of mitosisGO:0458409.8IL1B, IL1A, TNF
24negative regulation of smooth muscle cell proliferationGO:0486629.7IL12B, IL15, IFNG
25antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.7PSMB8, TAP1, TAP2
26humoral immune responseGO:0069599.7LTA, TNF, IFNG
27positive regulation of immune responseGO:0507789.7HLA-DMA, IL15
28positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IL1B, TNF, IFNG
29positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, TNF, IFNG
30positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF, IL1B
31regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.6IL1B, TNF
32positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF, IL1B
33positive regulation of interferon-gamma productionGO:0327299.6TNF, LTA, IL12B, IL1B
34negative regulation of growth of symbiont in hostGO:0441309.6IL12B, LTA, TNF, IFNG
35neutrophil aggregationGO:0704889.4S100A8, S100A9
36chemokine productionGO:0326029.4S100A9, S100A8
37sequestering of zinc ionGO:0321199.4S100A9, S100A8
38positive regulation of T cell proliferationGO:0421029.4IFNG, IL15, IL12B, IL1B
39cytokine-mediated signaling pathwayGO:0192219.3IFNG, PSMB8, HLA-DQB1, IL1A, IL1B
40leukocyte migration involved in inflammatory responseGO:0025239.3S100A8, S100A9
41regulation of insulin secretionGO:0507969.2IFNG, TNF, IL1B
42immune responseGO:0069559.1HLA-DQB1, IL15, IL1A, IL1B, SEMA7A
43chronic inflammatory responseGO:0025449.1S100A9, S100A8
44cell-cell signalingGO:0072678.8S100A9, LTA, IL15, IL1B
45apoptotic processGO:0069158.8IL1B, IL1A, LTA, PSMB8, TNF, IFNG
46positive regulation of inflammatory responseGO:0507298.7S100A9, S100A8, IL15, IL12B
47neutrophil chemotaxisGO:0305938.7IL1B, S100A8, S100A9, IFNG
48positive regulation of NF-kappaB transcription factor activityGO:0510928.6S100A9, S100A8, TNF, IL1B
49activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.3S100A9, S100A8, TNF
50inflammatory responseGO:0069547.6S100A9, S100A8, TNF, IL15, IL1A, IL1B

Molecular functions related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.3TAP1, TAP2
2peptide transporter activityGO:01519710.2TAP1, TAP2
3TAP2 bindingGO:04697910.2TAP1, TAP2
4TAP1 bindingGO:04697810.2TAP1, TAP2
5oligopeptide-transporting ATPase activityGO:01542110.1TAP1, TAP2
6MHC class I protein bindingGO:04228810.0TAP2, TAP1
7interleukin-1 receptor bindingGO:0051499.5IL1B, IL1A
8Toll-like receptor 4 bindingGO:0356629.1S100A9, S100A8
9arachidonic acid bindingGO:0505449.0S100A8, S100A9
10RAGE receptor bindingGO:0507868.9S100A9, S100A8
11cytokine activityGO:0051258.2IL1B, IL1A, IL12B, IL15, LTA, TNF

Products for genes affiliated with Cardiac Sarcoidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiac Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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