MCID: CRD003
MIFTS: 51

Cardiac Sarcoidosis malady

Immune diseases category
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Summaries for Cardiac Sarcoidosis

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33MalaCards
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MalaCards: Cardiac Sarcoidosis is related to sarcoidosis and dilated cardiomyopathy. An important gene associated with Cardiac Sarcoidosis is PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8), and among its related pathways are TRAF Pathway and IL12-mediated signaling events. The compounds lipoteichoic acid and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Cardiac Sarcoidosis

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

cardiac sarcoidosis 8 62


External Ids:

Disease Ontology8 DOID:13405
SNOMED-CT58 75403004
NCIt40 C35589

Related Diseases for Cardiac Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.3LTA, TAP2, TAP1, S100A9, IL1A, IL1B
2dilated cardiomyopathy30.2NPPB, ACE, HLA-DQB1
3pulmonary tuberculosis30.0IL12B, IFNG, HLA-DQB1
4coronary artery disease30.0LTA, NPPB, ACE
5tuberculosis29.8HLA-DQB1, TNF, IFNG, IL12B, IL1B
6atrioventricular block10.5
7aneurysm10.3
8arrhythmogenic right ventricular dysplasia10.3
9myocarditis10.3
10hypertrophic cardiomyopathy10.2
11giant cell myocarditis10.2
12degenerative disc disease10.1IL1B
13pulpitis10.1IL1A
14periodontal disease10.1TNF
15celiac disease10.1IL15, HLA-DQB1
16pleurisy10.1IL1B
17oligohydramnios10.1ACE
18mixed connective tissue disease10.1S100A9, S100A8
19encephalitis10.1IL12B, IL1B
20leishmaniasis10.1IFNG
21asthma10.1IL12B, TNF
22tonsillitis10.1IL1A, LTA
23middle ear cholesteatoma10.1IL1A, S100A8
24duodenal ulcer10.1S100A8, LTA
25periodontitis10.1IL1B, IL1A
26shigellosis10.1LTA, IL1B
27skin disease10.1IL1B, IL1A
28dermatomyositis10.1IL1A, S100A9, S100A8
29bacterial vaginosis10.0IL1B, IL1A
30schizophrenia10.0HLA-DQB1, TAP1, LTA
31spondylarthropathy10.0TNF, S100A9, S100A8
32ankylosing spondylitis10.0TAP2, TAP1, TNF
33sjogren's syndrome10.0S100A9, S100A8, TAP1, TAP2
34lepromatous leprosy10.0LTA, IFNG
35blau syndrome10.0TNF, IL1B
36aids dementia complex10.0TNF, IL1B
37hypertensive heart disease10.0NPPB, ACE
38visceral leishmaniasis10.0IFNG, LTA
39idiopathic edema10.0ACE, NPPB
40alcoholic hepatitis10.0TNF, IL1A
41gingival overgrowth10.0IL1B, IL1A
42familial mediterranean fever10.0TNF, IL1B
43gout10.0S100A9, IL1B
44chorioamnionitis10.0TNF, IL1B
45polymyositis10.0IL15, IL1A, S100A9, S100A8
46tropical spastic paraparesis10.0IFNG, IL15
47adult respiratory distress syndrome10.0TNF, IL1B, LTA
48alopecia areata10.0IFNG, IL1A
49autoimmune thyroiditis10.0IL12B, IFNG, PSMB8
50bronchitis10.0S100A9, S100A8

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to cardiac sarcoidosis

Symptoms for Cardiac Sarcoidosis

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Drugs & Therapeutics for Cardiac Sarcoidosis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cardiac Sarcoidosis

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

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Anatomical Context for Cardiac Sarcoidosis

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33MalaCards
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MalaCards organs/tissues related to Cardiac Sarcoidosis:

33
Heart, Bone, Brain, Myeloid, T cells, Lymph node

Animal Models for Cardiac Sarcoidosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7LTA, ACE, IFNG, TNF, HLA-DQB1
2MP:00020067.9TNF, PSMB8, IFNG, ACE, IL12B, IL1B
3MP:00053857.1HLA-DQB1, TNF, IFNG, ACE, IL15, IL1B
4MP:00053766.9HLA-DQB1, TNF, IFNG, ACE, IL12B, IL1B
5MP:00053975.6LTA, HLA-DMA, HLA-DQB1, TNF, PSMB8, IFNG
6MP:00053875.5ACE, IFNG, PSMB8, TNF, HLA-DQB1, HLA-DMA
7MP:00107685.4ACE, IFNG, TNF, HLA-DQB1, HLA-DMA, IL15

Publications for Cardiac Sarcoidosis

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52PubMed
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Articles related to Cardiac Sarcoidosis:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography. (24429936)
2014
2
The difficult diagnosis of isolated cardiac sarcoidosis: usefulness of an integrated MRI and PET approach. (23838000)
2014
3
Cardiac Sarcoidosis: Electrophysiological Outcomes on Long-Term Follow-Up and the Role of the Implantable Cardioverter-Defibrillator. (24433308)
2013
4
Efficacy of heparin loading during an 18F-FDG PET/CT examination to search for cardiac sarcoidosis activity. (23334129)
2013
5
The invisible made visible: multi-modality imaging in the evaluation of cardiac sarcoidosis. (23391582)
2013
6
Complete somatostatin-induced insulin suppression combined with heparin loading does not significantly suppress myocardial 18F-FDG uptake in patients with suspected cardiac sarcoidosis. (24132814)
2013
7
Malignant ventricular arrhythmia as the first manifestation of cardiac sarcoidosis. (24104986)
2013
8
Inactive cardiac sarcoidosis with characteristic findings on cardiac MRI. (24177462)
2013
9
Cardiac sarcoidosis. (23844704)
2013
10
Response to steroid therapy in cardiac sarcoidosis: insights from myocardial strain. (21990278)
2012
11
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia with high defibrillation threshold requiring subcutaneous shocking coil implantation. (21982156)
2012
12
Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (22944174)
2012
13
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
14
Diagnosis and monitoring of cardiac sarcoidosis with delayed-enhanced MRI and 18F-FDG PET-CT. (22466988)
2012
15
Cardiac sarcoidosis presenting with complete atrioventricular block and sustained monomorphic ventricular tachycardia. (22977456)
2012
16
Arrhythmias in cardiac sarcoidosis: diagnosis and treatment. (22186166)
2012
17
Cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy. (21937273)
2012
18
Diagnosis of cardiac sarcoidosis through mismatched defects seen on N-13 NH3/F-18 FDG cardiac PET. (22064101)
2011
19
Cardiac sarcoidosis: a comprehensive review. (22291785)
2011
20
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
21
Cardiac sarcoidosis. (20665393)
2010
22
Diagnosing cardiac sarcoidosis clinically without tissue confirmation. (19633746)
2009
23
Dual left ventricular restorations in a patient with cardiac sarcoidosis. (19380011)
2009
24
Multiple involvements of cardiac sarcoidosis in both left and right ventricles and papillary muscles detected by delayed-enhanced magnetic resonance imaging. (17689728)
2008
25
Successful treatment of cardiac sarcoidosis with infliximab. (18671332)
2008
26
Exercise intolerance and multiple conduction abnormalities as first manifestation of cardiac sarcoidosis. (18791500)
2008
27
Cardiac sarcoidosis: a case report. (19044177)
2008
28
An unappetizing dog bone: cardiac sarcoidosis presenting with heart block and unusual left ventricular bulging. (18065753)
2008
29
Complementary appearance of glucose and lipid metabolism in cardiac sarcoidosis. (16872698)
2007
30
Reversible exercise-induced advanced atrioventricular block due to cardiac sarcoidosis. (17199004)
2007
31
Usefulness of late gadolinium enhancement combined with MRI and 67-Ga scintigraphy in the diagnosis of cardiac sarcoidosis and disease activity evaluation. (16868855)
2007
32
Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis. (17895549)
2007
33
Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)
2007
34
The intricacies of cardiac sarcoidosis: a case report involving the coronary arteries and a review of the literature. (16844554)
2006
35
Images in cardiology. Biventricular involvement in cardiac sarcoidosis. (16230435)
2005
36
Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis. (15881282)
2005
37
Cardiac sarcoidosis: there is no instant replay. (16002904)
2005
38
Diagnostic Value of PET in Cardiac Sarcoidosis. (15534072)
2004
39
Cardiac sarcoidosis: two cases with autopsy findings. (16196153)
2004
40
Cardiac sarcoidosis detected by delayed-hyperenhancement magnetic resonance imaging. (15061637)
2004
41
Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. (11577764)
2001
42
Discrepancy between inducibility of ventricular tachycardia and activity of cardiac sarcoidosis. Requirement of defibrillator implantation for the inactive stage of cardiac sarcoidosis. (11518112)
2001
43
HLA-DQB1*0601 is primarily associated with the susceptibility to cardiac sarcoidosis. (10958356)
2000
44
Incidence of cardiac sarcoidosis in Japanese patients with high-degree atrioventricular block. (9327691)
1997
45
Sudden death due to cardiac sarcoidosis in a case of suspected homicide. (8217872)
1993
46
Cardiac sarcoidosis. (2355460)
1990
47
Two dimensional echocardiography and left ventriculography in cardiac sarcoidosis. (2631668)
1989
48
Cardiac sarcoidosis: two cases with ventricular tachycardia and review of cardiac involvement in sarcoid. (15227374)
1986
49
Cardiac sarcoidosis. Diagnosis with endomyocardial biopsy and treatment with corticosteroids. (677030)
1978
50
MYOCARDIAL DEGENERATION IN CARDIAC SARCOIDOSIS: HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES. (14256691)
1965

Variations for Cardiac Sarcoidosis

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Expression for genes affiliated with Cardiac Sarcoidosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for genes affiliated with Cardiac Sarcoidosis

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 30KEGG, 55Reactome
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Pathways related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5LTA, IL12B, TNF
2
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IL1B, IL12B, IFNG
3
Show member pathways
9.5IFNG, IL12B, IL1B
49.5IFNG, IL1B, TAP1
59.4IL1B, IL12B, TNF
6
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4HLA-DMA, HLA-DQB1, IL12B
79.4LTA, IL1B, TNF
89.4IL1A, IL1B, IFNG
9
Show member pathways
9.4IL1A, IL1B, IFNG
109.4TNF, IL1B, IL1A
119.4TNF, IL1B, IL1A
12
Show member pathways
9.4TNF, IFNG, LTA
139.3TNF, IFNG, IL1B
14
Show member pathways
thioredoxin pathway38
9.3TNF, IFNG, IL1B
159.2TAP2, TAP1, HLA-DQB1, HLA-DMA
169.1IL1A, IL1B, IL12B, TNF
17
Show member pathways
9.1TNF, IL1B, IL1A, LTA
18
Show member pathways
9.1TNF, IL1B, IL1A, LTA
19
Show member pathways
9.1IL15, IFNG, TNF
209.0IL1B, IL12B, IFNG, TNF
21
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0IL1B, IL12B, IFNG, TNF
229.0TNF, IFNG, IL12B, IL1B
239.0TNF, IFNG, IL12B, IL1B
24
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0IL1A, IL1B, IFNG, TNF
25
Show member pathways
Immune response MIF in innate immunity response60
9.0IL1A, IL1B, IFNG, TNF
269.0IL1A, IL1B, IFNG, TNF
279.0TNF, IFNG, IL1B, IL1A
289.0TNF, IFNG, IL1B, IL1A
29
Show member pathways
8.9HLA-DMA, HLA-DQB1, PSMB8, TAP1, TAP2
30
Show member pathways
8.9HLA-DQB1, PSMB8, IFNG, IL1B, IL1A
318.9TNF, IL15, IL1B, LTA
32
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.9TAP2, TAP1, IFNG, PSMB8, TNF
33
Show member pathways
IL27-mediated signaling events38
8.8TNF, IFNG, IL12B, IL1B, LTA
34
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7TNF, IFNG, IL1B, IL1A, LTA
35
Show member pathways
8.7TNF, IFNG, IL1B, IL1A, LTA
36
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.7TNF, IFNG, ACE, IL12B, IL1B
378.5HLA-DMA, HLA-DQB1, TNF, IL15, LTA
38
Show member pathways
8.4TNF, IL15, IL12B, IL1B, IL1A, LTA
39
Show member pathways
8.4TNF, IL15, IL12B, IL1B, IL1A, LTA
40
Show member pathways
8.4LTA, IL1A, IL1B, IL12B, IL15, TNF
418.2TNF, IFNG, IL15, IL12B, IL1B, IL1A
42
Show member pathways
8.2HLA-DMA, HLA-DQB1, TNF, IFNG, IL1B, IL1A
43
Show member pathways
8.0TNF, IFNG, IL15, IL12B, IL1B, IL1A
448.0LTA, IL1A, IL1B, IL12B, IL15, IFNG
45
Show member pathways
7.9HLA-DMA, HLA-DQB1, TNF, IFNG, IL12B, IL1B
467.9HLA-DMA, HLA-DQB1, TNF, IFNG, IL12B, IL1B
47
Show member pathways
7.7TNF, PSMB8, IFNG, IL15, IL12B, IL1B
487.6HLA-DMA, HLA-DQB1, TNF, IFNG, IL15, IL1B
49
Show member pathways
6.6LTA, TAP2, TAP1, IL1A, IL1B, IL12B
50
Show member pathways
6.6IL12B, IL15, IFNG, TNF, HLA-DQB1, HLA-DMA

Compounds for genes affiliated with Cardiac Sarcoidosis

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1lipoteichoic acid459.5TNF, IL12B, IL1B, LTA
2sulfasalazine29 45 51 1112.5TNF, IL12B, IL1B, IL1A
3imiquimod45 61 29 1112.5TNF, IFNG, IL12B, IL1A
4gold sodium thiomalate459.4TNF, IFNG, IL1B, IL1A
5polymyxin b459.3TNF, IFNG, IL1B, IL1A
6okt3459.2TNF, IFNG, IL15, LTA
7ivig459.1TNF, IFNG, IL1B, IL1A, LTA
8neopterin459.1TNF, IFNG, IL1B, IL1A, LTA
9tenidap45 2910.1TNF, IL1B, IL1A
10l-nmma459.1TNF, IFNG, IL1B, NPPB
11herbimycin a45 6110.0TNF, IFNG, IL1B, IL1A, LTA
12il-12458.9TNF, IFNG, IL15, IL12B, IL1B
13poly(i-c)458.9IL1B, IL12B, IL15, IFNG, TNF
14peptidoglycan45 299.9TNF, IL15, IL12B, IL1B
15etanercept45 51 1110.9TNF, IFNG, IL15, IL1B, LTA
16infliximab45 51 1110.9TNF, IFNG, IL15, IL1B, LTA
17prostacyclin458.9TNF, ACE, IL1B, IL1A, NPPB
18gm-csf45 299.9TNF, IFNG, IL15, IL1B, IL1A
19p005458.9IL15, S100A8, NPPB, LTA
20ccl345 299.8TNF, IFNG, IL15, IL1B, IL1A
21ionomycin458.8TNF, IFNG, IL15, IL1A, LTA
224-ipp618.8IL1B, IL1A, S100A9, S100A8
23git 27618.8IL1B, IL1A, S100A9, S100A8
24sb 20358045 619.8TNF, IFNG, IL12B, IL1B, IL1A, NPPB
25hydrocortisone45 3 61 1111.8TNF, IFNG, IL15, IL1B, IL1A
26indomethacin45 29 61 1111.8TNF, IFNG, IL1B, IL1A, NPPB, LTA
27as 10145 619.8S100A8, S100A9, IL1A, IL1B
28fmlp458.7TNF, IL1B, IL1A, S100A9, LTA
29actinomycin d458.7TNF, IFNG, IL1B, IL1A, NPPB, LTA
30polyinosinic-polycytidylic acid458.7TNF, IFNG, IL15, IL12B, IL1B, IL1A
31pentoxifylline45 119.6TNF, IFNG, IL12B, IL1B, IL1A, NPPB
32monosodium urate458.6IL1B, S100A9, S100A8
33il 10458.4LTA, TNF, IFNG, IL15, IL12B, IL1B
34pirfenidone45 619.4IFNG, IL1B, IL1A, S100A9, S100A8
35cyclosporin a45 29 6110.4TNF, IFNG, IL15, IL1A, NPPB, LTA
36cycloheximide458.3TNF, IFNG, IL15, IL12B, IL1B, IL1A
37rantes458.3IFNG, IL15, IL12B, IL1B, IL1A, S100A8
38thymidine45 249.1NPPB, IL1A, IL1B, IL15, IFNG, TNF
39pge2458.1TNF, IFNG, IL15, IL12B, IL1B, IL1A
40vegf458.1TNF, IFNG, IL15, IL1B, IL1A, NPPB
41thalidomide45 51 61 1110.9TNF, IFNG, IL1B, IL1A, S100A9, S100A8
42histamine45 29 249.9TNF, IFNG, IL15, IL1B, S100A8, NPPB
43arachidonic acid45 29 24 1110.9TNF, IL1B, IL1A, S100A9, S100A8, LTA
44oligonucleotide457.8HLA-DMA, HLA-DQB1, IL15, S100A8, TAP1, TAP2
45calcitriol45 61 24 1110.7TNF, IFNG, IL1B, IL1A, S100A9, S100A8
46endotoxin457.5TNF, IFNG, IL12B, IL1B, IL1A, S100A9
47retinoic acid45 248.1TNF, IFNG, IL15, IL1B, IL1A, S100A9
48lipid457.0TNF, ACE, IL15, IL12B, S100A9, S100A8
49dexamethasone45 51 29 119.9TNF, IFNG, IL15, IL1B, IL1A, S100A9
50nitric oxide45 24 118.3TNF, IFNG, ACE, IL15, IL12B, IL1B

GO Terms for genes affiliated with Cardiac Sarcoidosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.9TAP1, TAP2
2MHC class II protein complexGO:0426139.4HLA-DQB1, HLA-DMA
3external side of plasma membraneGO:0098979.2ACE, IFNG, TNF
4extracellular regionGO:0055766.3TNF, IFNG, ACE, IL15, IL1B, IL1A
5extracellular spaceGO:0056155.9LTA, TNF, IFNG, ACE, IL15, IL12B

Biological processes related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.3TAP1, TAP2
2oligopeptide transmembrane transportGO:03567210.3TAP1, TAP2
3antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.3TAP1, TAP2
4intracellular transport of viral protein in host cellGO:01906010.3TAP1, TAP2
5fever generationGO:00166010.2IL1B, IL1A
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL12B, IL1B
7positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.2TNF, LTA
8positive regulation of T cell mediated cytotoxicityGO:00191610.1TAP2, TAP1, IL12B
9sequestering of triglycerideGO:03073010.0TNF, IL1B
10positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0TNF, LTA
11positive regulation of tissue remodelingGO:03410510.0IL15, IL12B
12peptide transportGO:01583310.0TAP1, TAP2
13positive regulation of natural killer cell proliferationGO:03281910.0IL15, IL12B
14positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
15positive regulation of fever generationGO:03162210.0TNF, IL1B
16positive regulation of vitamin D biosynthetic processGO:06055710.0TNF, IFNG
17ectopic germ cell programmed cell deathGO:03523410.0IL1B, IL1A
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.0TAP2, TAP1, PSMB8
19positive regulation of smooth muscle cell apoptotic processGO:0343939.9IFNG, IL12B
20positive regulation of interleukin-6 biosynthetic processGO:0454109.9IFNG, IL1B
21positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL12B, IL1B
22positive regulation of osteoclast differentiationGO:0456729.8TNF, IFNG, IL12B
23positive regulation of mitosisGO:0458409.8IL1A, IL1B, TNF
24negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1A, IL1B, TNF
25antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.7TAP2, TAP1, PSMB8
26negative regulation of smooth muscle cell proliferationGO:0486629.7IL12B, IL15, IFNG
27humoral immune responseGO:0069599.7LTA, IFNG, TNF
28positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IFNG, IL1B
29positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, IFNG, TNF
30positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG, IL1B
31positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, IFNG, IL1B
32positive regulation of interferon-gamma productionGO:0327299.6LTA, IL1B, IL12B, TNF
33positive regulation of immune responseGO:0507789.6HLA-DMA, IL15
34negative regulation of growth of symbiont in hostGO:0441309.6LTA, IL12B, IFNG, TNF
35negative regulation of interleukin-17 productionGO:0327009.5IL12B, IFNG
36neutrophil aggregationGO:0704889.4S100A9, S100A8
37chemokine productionGO:0326029.4S100A9, S100A8
38positive regulation of T cell proliferationGO:0421029.4IL1B, IL12B, IL15, IFNG
39sequestering of zinc ionGO:0321199.4S100A9, S100A8
40cytokine-mediated signaling pathwayGO:0192219.3HLA-DQB1, PSMB8, IFNG, IL1B, IL1A
41leukocyte migration involved in inflammatory responseGO:0025239.3S100A9, S100A8
42regulation of insulin secretionGO:0507969.2TNF, IFNG, IL1B
43cell-cell signalingGO:0072679.1IL15, IL1B, S100A9, LTA
44immune responseGO:0069559.0IL1A, IL1B, IL15, HLA-DQB1
45apoptotic processGO:0069158.9TNF, PSMB8, IFNG, IL1B, IL1A, LTA
46activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.8TNF, S100A9, S100A8
47neutrophil chemotaxisGO:0305938.7IFNG, IL1B, S100A9, S100A8
48positive regulation of inflammatory responseGO:0507298.7IL15, IL12B, S100A9, S100A8
49positive regulation of NF-kappaB transcription factor activityGO:0510928.6TNF, IL1B, S100A9, S100A8
50inflammatory responseGO:0069547.9TNF, IL15, IL1B, IL1A, S100A9, S100A8

Molecular functions related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.2TAP1, TAP2
2MHC class Ib protein bindingGO:02302910.2TAP1, TAP2
3peptide transporter activityGO:01519710.2TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:01542110.2TAP1, TAP2
5TAP2 bindingGO:04697910.1TAP1, TAP2
6TAP1 bindingGO:04697810.1TAP1, TAP2
7peptide antigen bindingGO:04260510.0TAP2, TAP1
8MHC class I protein bindingGO:0422889.9TAP2, TAP1
9interleukin-1 receptor bindingGO:0051499.8IL1B, IL1A
10tumor necrosis factor receptor bindingGO:0051649.5LTA, TNF
11Toll-like receptor 4 bindingGO:0356629.3S100A9, S100A8
12arachidonic acid bindingGO:0505449.2S100A9, S100A8
13RAGE receptor bindingGO:0507869.1S100A8, S100A9
14cytokine activityGO:0051258.3LTA, TNF, IFNG, IL15, IL12B, IL1B
15protein bindingGO:0055156.5IL15, ACE, PSMB8, TNF, IL12B, IL1A

Products for genes affiliated with Cardiac Sarcoidosis

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  • Antibodies
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Sources for Cardiac Sarcoidosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet