MCID: CRD003
MIFTS: 52

Cardiac Sarcoidosis malady

Immune diseases category
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Summaries for Cardiac Sarcoidosis

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MalaCards based summary: Cardiac Sarcoidosis is related to dilated cardiomyopathy and pulmonary tuberculosis. An important gene associated with Cardiac Sarcoidosis is PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8), and among its related pathways are TRAF Pathway and IL12-mediated signaling events. The compounds lipoteichoic acid and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Cardiac Sarcoidosis

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Cardiac Sarcoidosis, Aliases & Descriptions:

Name: Cardiac Sarcoidosis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:13405
SNOMED-CT57 75403004
NCIt39 C35589

Related Diseases for Cardiac Sarcoidosis

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Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1dilated cardiomyopathy30.4ACE, HLA-DQB1, NPPB
2pulmonary tuberculosis30.1IL12B, IFNG, HLA-DQB1
3sarcoidosis29.6IFNG, TNF, LTA, TAP2, TAP1, S100A9
4tuberculosis29.4HLA-DQB1, IL12B, TNF, IFNG, IL1B
5atrioventricular block10.5
6degenerative disc disease10.5IL1B
7pulpitis10.5IL1A
8periodontal disease10.4TNF
9celiac disease10.4HLA-DQB1, IL15
10arrhythmogenic right ventricular cardiomyopathy10.4
11myocarditis10.4
12aneurysm10.4
13pleurisy10.4IL1B
14oligohydramnios10.3ACE
15mixed connective tissue disease10.3S100A8, S100A9
16encephalitis10.3IL1B, IL12B
17leishmaniasis10.3IFNG
18giant cell myocarditis10.3
19asthma10.3IL12B, TNF
20tonsillitis10.3LTA, IL1A
21middle ear cholesteatoma10.3IL1A, S100A8
22duodenal ulcer10.3S100A8, LTA
23periodontitis10.3IL1B, IL1A
24shigellosis10.3IL1B, LTA
25skin disease10.3IL1B, IL1A
26hypertrophic cardiomyopathy10.2
27dermatomyositis10.2IL1A, S100A9, S100A8
28schizophrenia10.2LTA, TAP1, HLA-DQB1
29bacterial vaginosis10.2IL1B, IL1A
30spondylarthropathy10.2S100A8, TNF, S100A9
31ankylosing spondylitis10.2TAP2, TAP1, TNF
32sjogren's syndrome10.2TAP2, S100A9, S100A8, TAP1
33lepromatous leprosy10.2IFNG, LTA
34blau syndrome10.2IL1B, TNF
35hypertensive heart disease10.2NPPB, ACE
36aids dementia complex10.2TNF, IL1B
37visceral leishmaniasis10.2IFNG, LTA
38idiopathic edema10.2NPPB, ACE
39alcoholic hepatitis10.2IL1A, TNF
40gingival overgrowth10.1IL1B, IL1A
41familial mediterranean fever10.1IL1B, TNF
42gout10.1S100A9, IL1B
43chorioamnionitis10.1TNF, IL1B
44polymyositis10.1S100A9, S100A8, IL1A, IL15
45gingivitis10.1IL1A, IL1B
46adult respiratory distress syndrome10.1TNF, IL1B, LTA
47tropical spastic paraparesis10.1IL15, IFNG
48alopecia areata10.1IFNG, IL1A
49autoimmune thyroiditis10.1IL12B, IFNG, PSMB8
50bronchitis10.1S100A9, S100A8

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to cardiac sarcoidosis

Symptoms for Cardiac Sarcoidosis

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Drugs & Therapeutics for Cardiac Sarcoidosis

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Drug clinical trials:

Search ClinicalTrials for Cardiac Sarcoidosis

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

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Anatomical Context for Cardiac Sarcoidosis

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MalaCards organs/tissues related to Cardiac Sarcoidosis:

32
Heart, Bone, Brain, Myeloid, T cells, Lymph node

Animal Models for Cardiac Sarcoidosis or affiliated genes

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MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7LTA, ACE, IFNG, TNF, HLA-DQB1
2MP:00020067.9TNF, PSMB8, IFNG, ACE, IL12B, IL1B
3MP:00053857.1HLA-DQB1, TNF, IFNG, ACE, IL15, IL1B
4MP:00053766.9HLA-DQB1, TNF, IFNG, ACE, IL12B, IL1B
5MP:00053975.6LTA, HLA-DMA, HLA-DQB1, TNF, PSMB8, IFNG
6MP:00053875.5ACE, IFNG, PSMB8, TNF, HLA-DQB1, HLA-DMA
7MP:00107685.4ACE, IFNG, TNF, HLA-DQB1, HLA-DMA, IL15

Publications for Cardiac Sarcoidosis

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Articles related to Cardiac Sarcoidosis:

(show top 50)    (show all 357)
idTitleAuthorsYear
1
Cardiac sarcoidosis. (24969032)
2014
2
Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography. (24429936)
2014
3
Quantifying myocardial inflammation using F18-fluorodeoxyglucose positron emission tomography in cardiac sarcoidosis. (24942609)
2014
4
Visual findings of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with cardiac sarcoidosis. (25224185)
2014
5
The difficult diagnosis of isolated cardiac sarcoidosis: usefulness of an integrated MRI and PET approach. (23838000)
2014
6
Cardiac Sarcoidosis: Electrophysiological Outcomes on Long-Term Follow-Up and the Role of the Implantable Cardioverter-Defibrillator. (24433308)
2013
7
Efficacy of heparin loading during an 18F-FDG PET/CT examination to search for cardiac sarcoidosis activity. (23334129)
2013
8
The invisible made visible: multi-modality imaging in the evaluation of cardiac sarcoidosis. (23391582)
2013
9
Complete somatostatin-induced insulin suppression combined with heparin loading does not significantly suppress myocardial 18F-FDG uptake in patients with suspected cardiac sarcoidosis. (24132814)
2013
10
Malignant ventricular arrhythmia as the first manifestation of cardiac sarcoidosis. (24104986)
2013
11
Inactive cardiac sarcoidosis with characteristic findings on cardiac MRI. (24177462)
2013
12
Cardiac sarcoidosis. (23844704)
2013
13
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia with high defibrillation threshold requiring subcutaneous shocking coil implantation. (21982156)
2012
14
Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (22944174)
2012
15
Sudden death due to pulmonary embolism in a patient with cardiac sarcoidosis. (22706660)
2012
16
Cardiac sarcoidosis presenting with complete atrioventricular block and sustained monomorphic ventricular tachycardia. (22977456)
2012
17
Arrhythmias in cardiac sarcoidosis: diagnosis and treatment. (22186166)
2012
18
Cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy. (21937273)
2012
19
Diagnosis of cardiac sarcoidosis through mismatched defects seen on N-13 NH3/F-18 FDG cardiac PET. (22064101)
2011
20
Cardiac sarcoidosis: a comprehensive review. (22291785)
2011
21
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
22
Cardiac sarcoidosis. (20665393)
2010
23
Diagnosing cardiac sarcoidosis clinically without tissue confirmation. (19633746)
2009
24
Dual left ventricular restorations in a patient with cardiac sarcoidosis. (19380011)
2009
25
Multiple involvements of cardiac sarcoidosis in both left and right ventricles and papillary muscles detected by delayed-enhanced magnetic resonance imaging. (17689728)
2008
26
Successful treatment of cardiac sarcoidosis with infliximab. (18671332)
2008
27
Exercise intolerance and multiple conduction abnormalities as first manifestation of cardiac sarcoidosis. (18791500)
2008
28
Cardiac sarcoidosis: a case report. (19044177)
2008
29
An unappetizing dog bone: cardiac sarcoidosis presenting with heart block and unusual left ventricular bulging. (18065753)
2008
30
Complementary appearance of glucose and lipid metabolism in cardiac sarcoidosis. (16872698)
2007
31
Reversible exercise-induced advanced atrioventricular block due to cardiac sarcoidosis. (17199004)
2007
32
Usefulness of late gadolinium enhancement combined with MRI and 67-Ga scintigraphy in the diagnosis of cardiac sarcoidosis and disease activity evaluation. (16868855)
2007
33
Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis. (17895549)
2007
34
Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)
2007
35
The intricacies of cardiac sarcoidosis: a case report involving the coronary arteries and a review of the literature. (16844554)
2006
36
Images in cardiology. Biventricular involvement in cardiac sarcoidosis. (16230435)
2005
37
Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis. (15881282)
2005
38
Cardiac sarcoidosis: there is no instant replay. (16002904)
2005
39
Diagnostic Value of PET in Cardiac Sarcoidosis. (15534072)
2004
40
Cardiac sarcoidosis: two cases with autopsy findings. (16196153)
2004
41
Cardiac sarcoidosis detected by delayed-hyperenhancement magnetic resonance imaging. (15061637)
2004
42
Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. (11577764)
2001
43
Discrepancy between inducibility of ventricular tachycardia and activity of cardiac sarcoidosis. Requirement of defibrillator implantation for the inactive stage of cardiac sarcoidosis. (11518112)
2001
44
HLA-DQB1*0601 is primarily associated with the susceptibility to cardiac sarcoidosis. (10958356)
2000
45
Incidence of cardiac sarcoidosis in Japanese patients with high-degree atrioventricular block. (9327691)
1997
46
Sudden death due to cardiac sarcoidosis in a case of suspected homicide. (8217872)
1993
47
Cardiac sarcoidosis. (2355460)
1990
48
Two dimensional echocardiography and left ventriculography in cardiac sarcoidosis. (2631668)
1989
49
Cardiac sarcoidosis: two cases with ventricular tachycardia and review of cardiac involvement in sarcoid. (15227374)
1986
50
Cardiac sarcoidosis. Diagnosis with endomyocardial biopsy and treatment with corticosteroids. (677030)
1978

Variations for Cardiac Sarcoidosis

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Expression for genes affiliated with Cardiac Sarcoidosis

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Expression patterns in normal tissues for genes affiliated with Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for genes affiliated with Cardiac Sarcoidosis

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Pathways related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5LTA, IL12B, TNF
2
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IL1B, IL12B, IFNG
3
Show member pathways
9.5IFNG, IL12B, IL1B
49.5IFNG, IL1B, TAP1
59.4IL1B, IL12B, TNF
6
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4HLA-DMA, HLA-DQB1, IL12B
79.4LTA, IL1B, TNF
89.4IL1A, IL1B, IFNG
9
Show member pathways
9.4IL1A, IL1B, IFNG
109.4TNF, IL1B, IL1A
119.4TNF, IL1B, IL1A
12
Show member pathways
9.4TNF, IFNG, LTA
139.3TNF, IFNG, IL1B
14
Show member pathways
thioredoxin pathway37
9.3TNF, IFNG, IL1B
159.2TAP2, TAP1, HLA-DQB1, HLA-DMA
169.1IL1A, IL1B, IL12B, TNF
17
Show member pathways
9.1TNF, IL1B, IL1A, LTA
18
Show member pathways
9.1TNF, IL1B, IL1A, LTA
19
Show member pathways
9.1IL15, IFNG, TNF
209.0IL1B, IL12B, IFNG, TNF
21
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0IL1B, IL12B, IFNG, TNF
229.0TNF, IFNG, IL12B, IL1B
239.0TNF, IFNG, IL12B, IL1B
24
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.0IL1A, IL1B, IFNG, TNF
25
Show member pathways
Immune response MIF in innate immunity response60
9.0IL1A, IL1B, IFNG, TNF
269.0IL1A, IL1B, IFNG, TNF
279.0TNF, IFNG, IL1B, IL1A
289.0TNF, IFNG, IL1B, IL1A
29
Show member pathways
8.9HLA-DMA, HLA-DQB1, PSMB8, TAP1, TAP2
30
Show member pathways
8.9HLA-DQB1, PSMB8, IFNG, IL1B, IL1A
318.9TNF, IL15, IL1B, LTA
32
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.9TAP2, TAP1, IFNG, PSMB8, TNF
33
Show member pathways
IL27-mediated signaling events37
8.8TNF, IFNG, IL12B, IL1B, LTA
34
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7TNF, IFNG, IL1B, IL1A, LTA
35
Show member pathways
8.7TNF, IFNG, IL1B, IL1A, LTA
36
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.7TNF, IFNG, ACE, IL12B, IL1B
378.5HLA-DMA, HLA-DQB1, TNF, IL15, LTA
38
Show member pathways
8.4TNF, IL15, IL12B, IL1B, IL1A, LTA
39
Show member pathways
8.4TNF, IL15, IL12B, IL1B, IL1A, LTA
40
Show member pathways
8.4LTA, IL1A, IL1B, IL12B, IL15, TNF
418.2TNF, IFNG, IL15, IL12B, IL1B, IL1A
42
Show member pathways
8.2HLA-DMA, HLA-DQB1, TNF, IFNG, IL1B, IL1A
43
Show member pathways
8.0TNF, IFNG, IL15, IL12B, IL1B, IL1A
448.0LTA, IL1A, IL1B, IL12B, IL15, IFNG
45
Show member pathways
7.9HLA-DMA, HLA-DQB1, TNF, IFNG, IL12B, IL1B
467.9HLA-DMA, HLA-DQB1, TNF, IFNG, IL12B, IL1B
47
Show member pathways
7.7TNF, PSMB8, IFNG, IL15, IL12B, IL1B
487.6HLA-DMA, HLA-DQB1, TNF, IFNG, IL15, IL1B
49
Show member pathways
6.6LTA, TAP2, TAP1, IL1A, IL1B, IL12B
50
Show member pathways
6.6IL12B, IL15, IFNG, TNF, HLA-DQB1, HLA-DMA

Compounds for genes affiliated with Cardiac Sarcoidosis

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Compounds related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1lipoteichoic acid449.5LTA, TNF, IL12B, IL1B
2sulfasalazine28 44 50 1112.5IL1A, IL12B, IL1B, TNF
3imiquimod44 61 28 1112.5IL1A, IL12B, IFNG, TNF
4gold sodium thiomalate449.4IL1B, IFNG, IL1A, TNF
5polymyxin b449.3IL1B, TNF, IFNG, IL1A
6tenidap44 2810.3IL1B, TNF, IL1A
7okt3449.2LTA, IL15, IFNG, TNF
8ivig449.1LTA, IL1B, IL1A, TNF, IFNG
9neopterin449.1LTA, IL1B, IFNG, TNF, IL1A
10l-nmma449.1TNF, NPPB, IL1B, IFNG
11herbimycin a44 6110.0IL1A, IL1B, IFNG, LTA, TNF
12il-12448.9IL1B, IL12B, IFNG, TNF, IL15
13poly(i-c)448.9IL1B, IL15, IL12B, IFNG, TNF
14peptidoglycan44 289.9TNF, IL15, IL12B, IL1B
15etanercept44 50 1110.9TNF, IL15, LTA, IL1B, IFNG
16infliximab44 50 1110.9LTA, IFNG, IL1B, IL15, TNF
17prostacyclin448.9NPPB, IL1B, ACE, TNF, IL1A
18gm-csf44 289.9IL1A, TNF, IL15, IFNG, IL1B
19p005448.9S100A8, LTA, NPPB, IL15
20ccl344 289.8IL1B, IL15, IFNG, IL1A, TNF
21ionomycin448.8IL15, LTA, IL1A, IFNG, TNF
22git 27618.8S100A8, IL1A, IL1B, S100A9
234-ipp618.8S100A8, S100A9, IL1A, IL1B
24sb 20358044 619.8IL12B, IL1A, NPPB, TNF, IFNG, IL1B
25hydrocortisone44 2 61 1111.8IL15, IL1B, IFNG, IL1A, TNF
26indomethacin44 28 61 1111.8IL1B, NPPB, IL1A, IFNG, TNF, LTA
27as 10144 619.8S100A8, IL1B, IL1A, S100A9
28fmlp448.7TNF, IL1B, S100A9, LTA, IL1A
29actinomycin d448.7IL1A, IFNG, TNF, IL1B, LTA, NPPB
30polyinosinic-polycytidylic acid448.7IL12B, IL1B, IL1A, IL15, TNF, IFNG
31pentoxifylline44 119.6IFNG, TNF, IL12B, LTA, NPPB, IL1A
32il 10448.4IL1B, IL12B, TNF, IFNG, IL15, IL1A
33pirfenidone44 619.4IFNG, IL1A, S100A9, S100A8, IL1B
34monosodium urate448.4IL1B, S100A8, S100A9
35cyclosporin a44 28 6110.4IL15, TNF, IFNG, IL1A, NPPB, LTA
36cycloheximide448.3IL1A, IL12B, TNF, IFNG, LTA, IL1B
37rantes448.3IL1B, IL1A, IL15, S100A8, IFNG, IL12B
38thymidine44 249.1NPPB, IL15, IL1A, IL1B, IFNG, TNF
39pge2448.1TNF, IFNG, IL15, IL12B, IL1A, NPPB
40vegf448.1IFNG, IL15, TNF, IL1B, LTA, IL1A
41thalidomide44 50 61 1110.9IL1B, IL1A, IFNG, S100A8, S100A9, TNF
42histamine44 28 249.9IL15, TNF, S100A8, IL1B, NPPB, IFNG
43arachidonic acid44 28 24 1110.9IL1A, LTA, S100A8, S100A9, TNF, IL1B
44oligonucleotide447.8HLA-DQB1, HLA-DMA, IL15, S100A8, TAP1, TAP2
45calcitriol44 61 24 1110.7TNF, IFNG, LTA, S100A8, IL1A, IL1B
46endotoxin447.5IL12B, IL1B, IL1A, S100A9, S100A8, LTA
47retinoic acid44 248.1S100A8, IL15, IFNG, TNF, S100A9, IL1B
48lipid447.0LTA, NPPB, S100A9, IL12B, IL15, ACE
49dexamethasone44 50 28 119.9TNF, NPPB, S100A9, S100A8, IL1A, IL1B
50nitric oxide44 24 118.3IFNG, ACE, IL15, IL12B, IL1A, S100A9

GO Terms for genes affiliated with Cardiac Sarcoidosis

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Cellular components related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.9TAP1, TAP2
2MHC class II protein complexGO:0426139.4HLA-DQB1, HLA-DMA
3external side of plasma membraneGO:0098979.2ACE, IFNG, TNF
4extracellular regionGO:0055766.3TNF, IFNG, ACE, IL15, IL1B, IL1A
5extracellular spaceGO:0056155.9LTA, TNF, IFNG, ACE, IL15, IL12B

Biological processes related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.3TAP1, TAP2
2oligopeptide transmembrane transportGO:03567210.3TAP1, TAP2
3antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.3TAP1, TAP2
4intracellular transport of viral protein in host cellGO:01906010.3TAP1, TAP2
5fever generationGO:00166010.2IL1B, IL1A
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL12B, IL1B
7positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.2TNF, LTA
8positive regulation of T cell mediated cytotoxicityGO:00191610.1TAP2, TAP1, IL12B
9sequestering of triglycerideGO:03073010.0TNF, IL1B
10positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0TNF, LTA
11positive regulation of tissue remodelingGO:03410510.0IL15, IL12B
12peptide transportGO:01583310.0TAP1, TAP2
13positive regulation of natural killer cell proliferationGO:03281910.0IL15, IL12B
14positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
15positive regulation of fever generationGO:03162210.0TNF, IL1B
16positive regulation of vitamin D biosynthetic processGO:06055710.0TNF, IFNG
17ectopic germ cell programmed cell deathGO:03523410.0IL1B, IL1A
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.0TAP2, TAP1, PSMB8
19positive regulation of smooth muscle cell apoptotic processGO:0343939.9IFNG, IL12B
20positive regulation of interleukin-6 biosynthetic processGO:0454109.9IFNG, IL1B
21positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL12B, IL1B
22positive regulation of osteoclast differentiationGO:0456729.8TNF, IFNG, IL12B
23positive regulation of mitosisGO:0458409.8IL1A, IL1B, TNF
24negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1A, IL1B, TNF
25antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.7TAP2, TAP1, PSMB8
26negative regulation of smooth muscle cell proliferationGO:0486629.7IL12B, IL15, IFNG
27humoral immune responseGO:0069599.7LTA, IFNG, TNF
28positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IFNG, IL1B
29positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, IFNG, TNF
30positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG, IL1B
31positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, IFNG, IL1B
32positive regulation of interferon-gamma productionGO:0327299.6LTA, IL1B, IL12B, TNF
33positive regulation of immune responseGO:0507789.6HLA-DMA, IL15
34negative regulation of growth of symbiont in hostGO:0441309.6LTA, IL12B, IFNG, TNF
35negative regulation of interleukin-17 productionGO:0327009.5IL12B, IFNG
36neutrophil aggregationGO:0704889.4S100A9, S100A8
37chemokine productionGO:0326029.4S100A9, S100A8
38positive regulation of T cell proliferationGO:0421029.4IL1B, IL12B, IL15, IFNG
39sequestering of zinc ionGO:0321199.4S100A9, S100A8
40cytokine-mediated signaling pathwayGO:0192219.3HLA-DQB1, PSMB8, IFNG, IL1B, IL1A
41leukocyte migration involved in inflammatory responseGO:0025239.3S100A9, S100A8
42regulation of insulin secretionGO:0507969.2TNF, IFNG, IL1B
43cell-cell signalingGO:0072679.1IL15, IL1B, S100A9, LTA
44immune responseGO:0069559.0IL1A, IL1B, IL15, HLA-DQB1
45apoptotic processGO:0069158.9TNF, PSMB8, IFNG, IL1B, IL1A, LTA
46activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.8TNF, S100A9, S100A8
47neutrophil chemotaxisGO:0305938.7IFNG, IL1B, S100A9, S100A8
48positive regulation of inflammatory responseGO:0507298.7IL15, IL12B, S100A9, S100A8
49positive regulation of NF-kappaB transcription factor activityGO:0510928.6TNF, IL1B, S100A9, S100A8
50inflammatory responseGO:0069547.9TNF, IL15, IL1B, IL1A, S100A9, S100A8

Molecular functions related to Cardiac Sarcoidosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.2TAP1, TAP2
2MHC class Ib protein bindingGO:02302910.2TAP1, TAP2
3peptide transporter activityGO:01519710.2TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:01542110.2TAP1, TAP2
5TAP2 bindingGO:04697910.1TAP1, TAP2
6TAP1 bindingGO:04697810.1TAP1, TAP2
7peptide antigen bindingGO:04260510.0TAP2, TAP1
8MHC class I protein bindingGO:0422889.9TAP2, TAP1
9interleukin-1 receptor bindingGO:0051499.8IL1B, IL1A
10tumor necrosis factor receptor bindingGO:0051649.5LTA, TNF
11Toll-like receptor 4 bindingGO:0356629.3S100A9, S100A8
12arachidonic acid bindingGO:0505449.2S100A9, S100A8
13RAGE receptor bindingGO:0507869.1S100A8, S100A9
14cytokine activityGO:0051258.3LTA, TNF, IFNG, IL15, IL12B, IL1B
15protein bindingGO:0055156.5IL15, ACE, PSMB8, TNF, IL12B, IL1A

Products for genes affiliated with Cardiac Sarcoidosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cardiac Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet