MCID: CRD003
MIFTS: 40

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 46 C35589
SNOMED-CT 64 75403004
UMLS 69 C0392077

Summaries for Cardiac Sarcoidosis

MalaCards based summary : Cardiac Sarcoidosis is related to epstein-barr virus-associated gastric carcinoma and alveolar echinococcosis. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Antigen processing-Cross presentation. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and lymph node, and related phenotypes are hematopoietic system and immune system

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 epstein-barr virus-associated gastric carcinoma 10.3 PSMB9 TNF
2 alveolar echinococcosis 10.3 TAP2 TNF
3 central nervous system vasculitis 10.2 SMUG1 TNF
4 tuberculous peritonitis 10.2 SMUG1 TNF
5 sialadenitis 10.2 TNC TNF
6 lymphangiosarcoma 10.2 SMUG1 TNF
7 hypersensitivity reaction type iv disease 10.2 SMUG1 TNF
8 cogan syndrome 10.2 SMUG1 TNF
9 atrioventricular block 10.1
10 pharynx cancer 10.1 PSMB9 SMUG1
11 spondylitis 10.0 TAP2 TNF
12 aneurysm 10.0
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 IL5 TNF
14 scleritis 10.0 IL5 TNF
15 arrhythmogenic right ventricular cardiomyopathy 10.0
16 cellulitis 10.0 IL5 TNF
17 pustulosis palmaris et plantaris 10.0 IL5 TNF
18 churg-strauss syndrome 10.0 IL5 TNF
19 paracoccidioidomycosis 10.0 IL5 TNF
20 echinococcosis 10.0 IL5 TNF
21 nose disease 9.9 IL5 TNF
22 parasitic helminthiasis infectious disease 9.9 IL5 TNF
23 upper respiratory tract disease 9.9 IL5 TNF
24 leukocyte disease 9.9 IL5 TNF
25 dilated cardiomyopathy 9.9
26 myocarditis 9.9
27 filariasis 9.9 IL5 TNF
28 keratoconjunctivitis 9.9 IL5 TNF
29 allergic contact dermatitis 9.9 IL5 TNF
30 gastroenteritis 9.9 IL5 TNF
31 atrial standstill 1 9.9
32 giant cell myocarditis 9.9
33 cutaneous leishmaniasis 9.8 IL5 TNF
34 bronchial disease 9.8 IL5 TNF
35 cow milk allergy 9.8 IL5 LGALS3
36 contact dermatitis 9.8 IL5 TNF
37 cardiac conduction defect 9.8
38 aging 9.8
39 hypertrophic cardiomyopathy 9.8
40 autoinflammation, lipodystrophy, and dermatosis syndrome 9.7 IL5 PSMB8 TNF
41 hypersensitivity reaction disease 9.7 IL5 TNF
42 progressive familial heart block, type ia 9.7
43 atrial fibrillation 9.7
44 mediastinitis 9.7
45 syncope 9.7
46 schistosomiasis 9.6 IL5 TNF
47 arteries, anomalies of 9.6
48 fibrosis of extraocular muscles, congenital, 1 9.6
49 immune suppression 9.6
50 wolff-parkinson-white syndrome 9.6

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 IL5 LGALS3 PSMB8 PSMB9 TAP2 TNF
2 immune system MP:0005387 9.43 IL5 LGALS3 PSMB8 PSMB9 TAP2 TNF
3 neoplasm MP:0002006 9.1 IL5 LGALS3 PSMB8 PSMB9 SMUG1 TNF

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists Phase 4
2 Hormones Phase 4
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
4 Ferrosoferric Oxide Phase 2, Phase 3
5 Hematinics Phase 2, Phase 3
6 Parenteral Nutrition Solutions Phase 2, Phase 3
7 Pharmaceutical Solutions Phase 2, Phase 3
8 Fluorodeoxyglucose F18 Phase 2
9 Radiopharmaceuticals Phase 2
10
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
2 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
3 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
4 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Recruiting NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
5 Cardiac Sarcoidosis: FDG PET vs. Ga-DOTANOC PET Completed NCT01729169
6 Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
7 Cardiac Sarcoidosis and FDG-PET Completed NCT00958087
8 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Recruiting NCT02812849 Cu-64 DOTATATE
9 Cardiac Sarcoidosis Multi-Center Prospective Cohort Recruiting NCT01477359
10 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Recruiting NCT02546388 Indium-111 Pentreotide
11 PET MRI Study in Patients With Cardiac Sarcoidosis Recruiting NCT03356756
12 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
13 Non-Invasive Characterization in Cardiac Sarcoidosis Active, not recruiting NCT02017522
14 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Active, not recruiting NCT01648933
15 18F-FDG PET Imaging in Cardiac Sarcoidosis No longer available NCT01764191

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

38
Heart, Monocytes, Lymph Node, T Cells, Myeloid, Testes, Brain

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 503)
# Title Authors Year
1
Gallium-68 DOTANOC scan in a patient withA suspected cardiac sarcoidosis. ( 29327255 )
2018
2
Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis. ( 29215412 )
2018
3
Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis. ( 29319785 )
2018
4
Cardiac Sarcoidosis Concomitant with Large-vessel Aortitis Detected by<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography. ( 29321427 )
2018
5
Isolated cardiac sarcoidosis - A rare disease entity? ( 29306463 )
2018
6
Recovery of High Degree Atrioventricular Block in a Patient with Cardiac Sarcoidosis by Corticosteroid Therapy. ( 29399570 )
2018
7
Establishing an Evidence-Based Method to Diagnose Cardiac Sarcoidosis: The Complementary Use of Cardiac Magnetic Resonance Imaging and FDG-PET. ( 29335273 )
2018
8
Isolated cardiac sarcoidosis: the crucial role of multimodal imaging with positron emission tomography/magnetic resonance imaging in diagnosis and therapy surveillance. ( 29182753 )
2018
9
A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance. ( 29405655 )
2018
10
A case of longitudinal care of a patient with cardiac sarcoidosis. ( 29423905 )
2018
11
Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment. ( 29406038 )
2018
12
Complementary Value of Cardiac Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Assessment of Cardiac Sarcoidosis. ( 29335272 )
2018
13
How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body<sup>18</sup>F-fluorodeoxyglucose positron emission tomography. ( 29306462 )
2018
14
Spontaneous regression of cardiac sarcoidosis resulting in total occlusion of coronary artery and ventricular aneurysm. ( 28063417 )
2017
15
The Challenges of Diagnosing Cardiac Sarcoidosis. ( 29216980 )
2017
16
Maximizing the Prognostic Value of Cardiac PET in Patients With Suspected Cardiac Sarcoidosis: A Simple Semiquantitative Score May Help. ( 28823739 )
2017
17
Isolated cardiac sarcoidosis masquerading as right ventricular outflow tract ventricular tachycardia. ( 28667170 )
2017
18
Prognostic Impact of Extent, Severity, and Heterogeneity of Abnormalities on (18)F-FDG PET Scans for Suspected Cardiac Sarcoidosis. ( 28823747 )
2017
19
Cardiac sarcoidosis: challenges in clinical practice. ( 28661904 )
2017
20
Serial FDG-PET scans help to identify steroid resistance in cardiac sarcoidosis. ( 27886616 )
2017
21
Unraveling Inflammation and Oxidative Stress in Cardiac Sarcoidosis. ( 29208597 )
2017
22
A complete heart block in a young male: a case report and review of literature of cardiac sarcoidosis. ( 27817119 )
2017
23
Electron microscopy gain a glimpse into the pathogenesis of cardiac sarcoidosis. ( 28633486 )
2017
24
Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients. ( 28686683 )
2017
25
Search for key manifestations to predict inflammation on cardiac PET in suspected cardiac sarcoidosis population. ( 28656555 )
2017
26
Fluorine-18 fluorodeoxyglucose positron emission tomography for cardiac sarcoidosis-is it time to consider a new radiotracer? ( 28853012 )
2017
27
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia in a patient presenting with monomorphic ventricular tachycardia. ( 28948146 )
2017
28
Cardiac sarcoidosis: a diagnostic and therapeutic challenge. ( 28675086 )
2017
29
Urinary 8-Hydroxy-2'-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis. ( 29208596 )
2017
30
Cardiac Sarcoidosis, Left Ventricular Impairment and Chronic Right Ventricular Pacing: Pacing or Pathology? ( 28652030 )
2017
31
Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy. ( 28438355 )
2017
32
Multimodality imaging in the diagnosis and management of cardiac sarcoidosis. ( 27837455 )
2017
33
Cardiovascular magnetic resonance imaging and clinical performance of somatostatin receptor positron emission tomography in cardiac sarcoidosis. ( 29231290 )
2017
34
Impact of early initiation of corticosteroid therapy on cardiac function and rhythm in patients with cardiac sarcoidosis. ( 27836297 )
2017
35
Heterogeneity of myocardial 2-[18F]fluoro-2-deoxy-D-glucose uptake is a typical feature in cardiac sarcoidosis: a study of 231 patients. ( 28950301 )
2017
36
Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis. ( 28624396 )
2017
37
Cardiac sarcoidosis diagnosed by multimodality imaging. ( 28752531 )
2017
38
The role of serial FDG PET for assessing therapeutic response in patients with cardiac sarcoidosis. ( 27813028 )
2017
39
Semi-quantitative metabolic values on FDG PET/CT including extracardiac sites of disease as a predictor of treatment course in patients with cardiac sarcoidosis. ( 28822108 )
2017
40
Cardiac sarcoidosis presenting as arrhythmogenic right ventricular cardiomyopathy/dysplasia with ventricular aneurysms: a case report. ( 29245138 )
2017
41
Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis. ( 27922863 )
2017
42
Utilizing and Interpreting FDG-PET/CT Images in Patients Referred for Assessment of Cardiac Sarcoidosis: The Devil is in the Details. ( 28663194 )
2017
43
Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011. ( 28904267 )
2017
44
Serial electrocardiographic changes in isolated cardiac sarcoidosis. ( 28826341 )
2017
45
Cardiac sarcoidosis resembling panic disorder: a case report. ( 28086847 )
2017
46
Emergence of Integrated Cardiac MagneticA Resonance/Positron Emission Tomography Imaging as the Preferred Imaging Modality in Cardiac Sarcoidosis. ( 28624409 )
2017
47
Cardiac sarcoidosis after glucocorticoid therapy evaluated by (18)F-fluorodeoxyglucose PET/MRI. ( 28913789 )
2017
48
Isolated Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy. ( 29225258 )
2017
49
Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction. ( 27867531 )
2016
50
Myocardial Immunocompetent Cells and Macrophage Phenotypes asA Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese. ( 27856486 )
2016

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteasome complex GO:0000502 9.26 PSMB8 PSMB9
2 proteasome core complex GO:0005839 9.16 PSMB8 PSMB9
3 proteasome core complex, beta-subunit complex GO:0019774 8.96 PSMB8 PSMB9
4 spermatoproteasome complex GO:1990111 8.62 PSMB8 PSMB9

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 LGALS3 PSMB8 PSMB9 TAP2
2 post-translational protein modification GO:0043687 9.63 PSMB8 PSMB9 TNC
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.5 PSMB8 PSMB9 TNF
4 NIK/NF-kappaB signaling GO:0038061 9.49 PSMB8 PSMB9
5 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.48 PSMB8 PSMB9
6 proteolysis involved in cellular protein catabolic process GO:0051603 9.43 PSMB8 PSMB9
7 regulation of cellular amino acid metabolic process GO:0006521 9.4 PSMB8 PSMB9
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.33 PSMB8 PSMB9 TAP2
9 positive regulation of podosome assembly GO:0071803 9.26 IL5 TNF
10 MAPK cascade GO:0000165 9.26 IL5 PSMB8 PSMB9 TNF
11 positive regulation of mononuclear cell migration GO:0071677 8.62 LGALS3 TNF

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 threonine-type endopeptidase activity GO:0004298 8.62 PSMB8 PSMB9

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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