MCID: CRD003
MIFTS: 38

Cardiac Sarcoidosis

Categories: Immune diseases

Aliases & Classifications for Cardiac Sarcoidosis

MalaCards integrated aliases for Cardiac Sarcoidosis:

Name: Cardiac Sarcoidosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13405
NCIt 47 C35589
SNOMED-CT 64 75403004
UMLS 69 C0392077

Summaries for Cardiac Sarcoidosis

MalaCards based summary : Cardiac Sarcoidosis is related to lymphoma and autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome. An important gene associated with Cardiac Sarcoidosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Antigen processing-Cross presentation. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and lymph node, and related phenotypes are hematopoietic system and immune system

Related Diseases for Cardiac Sarcoidosis

Diseases related to Cardiac Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.1 IL5 TNF
2 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.5 PSMB9 TNF
3 endocarditis 10.4 TNC TNF
4 central nervous system leiomyosarcoma 10.4 SMUG1 TNF
5 polyarteritis nodosa 10.4 SMUG1 TNF
6 aseptic meningitis 10.4 TAP2 TNF
7 membranoproliferative glomerulonephritis 10.3 SMUG1 TNF
8 crest syndrome 10.3 SMUG1 TNF
9 aortic arch interruption 10.3 IL5 TNF
10 urethral intrinsic sphincter deficiency 10.3 IL5 TNF
11 signet ring cell adenocarcinoma 10.3 IL5 TNF
12 pyridoxine deficiency 10.2 IL5 TNF
13 glioblastoma multiforme 10.2 IL5 TNF
14 integumentary system cancer 10.2 PSMB9 SMUG1
15 disease of mental health 10.2 IL5 TNF
16 abnormal retinal correspondence 10.2 IL5 TNF
17 dehydration polycythemia 10.2 IL5 TNF
18 sublingual gland cancer 10.2 IL5 TNF
19 pelvic varices 10.2 IL5 TNF
20 benign mammary dysplasia 10.1 IL5 TNF
21 gastric ulcer 10.1 IL5 TNF
22 cardiomyopathy 10.1
23 fuchs' heterochromic uveitis 10.1 IL5 TNF
24 churg-strauss syndrome 10.1 IL5 TNF
25 colon adenocarcinoma 10.1 IL5 TNF
26 atrioventricular block 10.1
27 dengue disease 10.0 IL5 TNF
28 spontaneous ocular nystagmus 10.0 IL5 TNF
29 cerebellar disease 10.0 IL5 TNF
30 aneurysm 9.9
31 ragweed sensitivity 9.9 IL5 PSMB8 TNF
32 muscle tissue disease 9.9 TAP2 TNF
33 nasal cavity carcinoma in situ 9.9 IL5 TNF
34 arrhythmogenic right ventricular cardiomyopathy 9.9
35 myocarditis 9.8
36 dilated cardiomyopathy 9.8
37 crustacean allergy 9.8 IL5 LGALS3
38 giant cell myocarditis 9.8
39 sudden cardiac death 9.7
40 atrial fibrillation 9.6
41 syncope 9.6
42 mediastinitis 9.6
43 uterus interstitial leiomyoma 9.6 IL5 TNF
44 acne 9.5
45 congestive heart failure 9.5
46 peritonitis 9.5
47 vasculitis 9.5
48 pulmonary embolism 9.5
49 artery disease 9.5
50 splenomegaly 9.5

Graphical network of the top 20 diseases related to Cardiac Sarcoidosis:



Diseases related to Cardiac Sarcoidosis

Symptoms & Phenotypes for Cardiac Sarcoidosis

MGI Mouse Phenotypes related to Cardiac Sarcoidosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 IL5 LGALS3 PSMB8 PSMB9 TAP2 TNF
2 immune system MP:0005387 9.43 LGALS3 PSMB8 PSMB9 TAP2 TNF IL5
3 neoplasm MP:0002006 9.1 IL5 LGALS3 PSMB8 PSMB9 SMUG1 TNF

Drugs & Therapeutics for Cardiac Sarcoidosis

Drugs for Cardiac Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists Phase 4
2 Hormones Phase 4
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
4
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
5
Bosentan Approved, Investigational Phase 2, Phase 3 147536-97-8 104865
6 Ferrosoferric Oxide Phase 2, Phase 3
7 Hematinics Phase 2, Phase 3
8 Parenteral Nutrition Solutions Phase 2, Phase 3
9 Pharmaceutical Solutions Phase 2, Phase 3
10 Adrenergic Agents Phase 2, Phase 3,Phase 1
11 Adrenergic Antagonists Phase 2, Phase 3
12 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
13 Adrenergic beta-Antagonists Phase 2, Phase 3
14 Anti-Arrhythmia Agents Phase 2, Phase 3
15 Antihypertensive Agents Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 Neurotransmitter Agents Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3
19 Sympatholytics Phase 2, Phase 3
20 Endothelin Receptor Antagonists Phase 2, Phase 3
21
Nitric Oxide Approved Phase 2 10102-43-9 145068
22
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
23 Anticholesteremic Agents Phase 2
24 Antimetabolites Phase 2
25 Atorvastatin Calcium Phase 2 134523-03-8
26 Calcium, Dietary Phase 2
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
28 Hypolipidemic Agents Phase 2
29 Lipid Regulating Agents Phase 2
30 Antioxidants Phase 2
31 Phosphodiesterase Inhibitors Phase 2
32 Platelet Aggregation Inhibitors Phase 2
33 Protective Agents Phase 2
34 Radiation-Protective Agents Phase 2
35 Vasodilator Agents Phase 2
36 Fluorodeoxyglucose F18 Phase 2
37 Radiopharmaceuticals Phase 2
38 Antibodies Phase 1
39 Autoantibodies Phase 1
40 Immunoglobulins Phase 1
41
Somatostatin Approved 38916-34-6, 51110-01-1 53481605
42 Alpha 1-Antitrypsin
43 Protein C Inhibitor

Interventional clinical trials:

(show all 23)

id Name Status NCT ID Phase Drugs
1 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
2 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
3 Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) Completed NCT01052428 Phase 2, Phase 3 metoprolol succinate (Toprol XL);Placebo
4 Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary Hypertension Completed NCT00581607 Phase 2, Phase 3 Bosentan;Placebo;Bosentan;Placebo
5 Atorvastatin to Treat Pulmonary Sarcoidosis Completed NCT00279708 Phase 2 Atorvastatin
6 Treatment of Pulmonary Sarcoidosis With Pentoxifylline Completed NCT00001877 Phase 2 Pentoxifylline
7 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
8 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Recruiting NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
9 Hematopoietic Stem Cell Support in Patients With Refractory Sarcoidosis Terminated NCT00282438 Phase 1, Phase 2
10 Safety, Pharmacokinetic and Pharmacodynamic Study of COR-1, an Anti-ß1 Receptor Antibody Cyclopeptide Completed NCT01043146 Phase 1 COR-1;placebo
11 Rehabilitation in Pulmonary Sarcoidosis: a Prospective Study Unknown status NCT01384123
12 Cardiac Sarcoidosis: FDG PET vs. Ga-DOTANOC PET Completed NCT01729169
13 Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis Completed NCT01013311
14 Cardiac Sarcoidosis and FDG-PET Completed NCT00958087
15 Genomic Research in Sarcoidosis Completed NCT01831739
16 Somatostatin Receptor Imaging in Cardiac Sarcoidosis Recruiting NCT02812849 Cu-64 DOTATATE
17 Cardiac Sarcoidosis Multi-Center Prospective Cohort Recruiting NCT01477359
18 Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis Recruiting NCT02546388 Indium-111 Pentreotide
19 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
20 Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis Recruiting NCT01745237
21 Non-Invasive Characterization in Cardiac Sarcoidosis Active, not recruiting NCT02017522
22 Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis Active, not recruiting NCT01648933
23 18F-FDG PET Imaging in Cardiac Sarcoidosis No longer available NCT01764191

Search NIH Clinical Center for Cardiac Sarcoidosis

Genetic Tests for Cardiac Sarcoidosis

Anatomical Context for Cardiac Sarcoidosis

MalaCards organs/tissues related to Cardiac Sarcoidosis:

39
Heart, Monocytes, Lymph Node, Testes, T Cells, Brain, Myeloid

Publications for Cardiac Sarcoidosis

Articles related to Cardiac Sarcoidosis:

(show top 50) (show all 484)
id Title Authors Year
1
Prognostic Impact of Extent, Severity, and Heterogeneity of Abnormalities on (18)F-FDG PET Scans for Suspected Cardiac Sarcoidosis. ( 28823747 )
2017
2
Cardiac sarcoidosis: a diagnostic and therapeutic challenge. ( 28675086 )
2017
3
Utilizing and Interpreting FDG-PET/CT Images in Patients Referred for Assessment of Cardiac Sarcoidosis: The Devil is in the Details. ( 28663194 )
2017
4
Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients. ( 28686683 )
2017
5
A complete heart block in a young male: a case report and review of literature of cardiac sarcoidosis. ( 27817119 )
2017
6
Cardiac Sarcoidosis, Left Ventricular Impairment and Chronic Right Ventricular Pacing: Pacing or Pathology? ( 28652030 )
2017
7
Isolated cardiac sarcoidosis masquerading as right ventricular outflow tract ventricular tachycardia. ( 28667170 )
2017
8
The role of serial FDG PET for assessing therapeutic response in patients with cardiac sarcoidosis. ( 27813028 )
2017
9
Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011. ( 28904267 )
2017
10
Serial electrocardiographic changes in isolated cardiac sarcoidosis. ( 28826341 )
2017
11
Cardiac sarcoidosis after glucocorticoid therapy evaluated by (18)F-fluorodeoxyglucose PET/MRI. ( 28913789 )
2017
12
Fluorine-18 fluorodeoxyglucose positron emission tomography for cardiac sarcoidosis-is it time to consider a new radiotracer? ( 28853012 )
2017
13
Semi-quantitative metabolic values on FDG PET/CT including extracardiac sites of disease as a predictor of treatment course in patients with cardiac sarcoidosis. ( 28822108 )
2017
14
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia in a patient presenting with monomorphic ventricular tachycardia. ( 28948146 )
2017
15
Serial FDG-PET scans help to identify steroid resistance in cardiac sarcoidosis. ( 27886616 )
2017
16
Search for key manifestations to predict inflammation on cardiac PET in suspected cardiac sarcoidosis population. ( 28656555 )
2017
17
Electron microscopy gain a glimpse into the pathogenesis of cardiac sarcoidosis. ( 28633486 )
2017
18
Multimodality imaging in the diagnosis and management of cardiac sarcoidosis. ( 27837455 )
2017
19
Maximizing the Prognostic Value of Cardiac PET in Patients With Suspected Cardiac Sarcoidosis: A Simple Semiquantitative Score May Help. ( 28823739 )
2017
20
Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis. ( 28624396 )
2017
21
Emergence of Integrated Cardiac MagneticA Resonance/Positron Emission Tomography Imaging as the Preferred Imaging Modality in Cardiac Sarcoidosis. ( 28624409 )
2017
22
Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy. ( 28438355 )
2017
23
Cardiac sarcoidosis: challenges in clinical practice. ( 28661904 )
2017
24
Impact of early initiation of corticosteroid therapy on cardiac function and rhythm in patients with cardiac sarcoidosis. ( 27836297 )
2017
25
Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis. ( 27922863 )
2017
26
Cardiac sarcoidosis diagnosed by multimodality imaging. ( 28752531 )
2017
27
Heterogeneity of myocardial 2-[18F]fluoro-2-deoxy-D-glucose uptake is a typical feature in cardiac sarcoidosis: a study of 231 patients. ( 28950301 )
2017
28
Spontaneous regression of cardiac sarcoidosis resulting in total occlusion of coronary artery and ventricular aneurysm. ( 28063417 )
2017
29
Cardiac sarcoidosis resembling panic disorder: a case report. ( 28086847 )
2017
30
Primary Cardiac Sarcoidosis with Syncope and Refractory Atrial Arrhythmia: A Case Report and Review of the Literature. ( 27303240 )
2016
31
Outcome of Patients With Cardiac Sarcoidosis Who Received Cardiac Resynchronization Therapy: Comparison With Dilated Cardiomyopathy Patients. ( 27862596 )
2016
32
Prognostic Value of Myocardial Scarring on CMR in Patients With Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis. ( 27450877 )
2016
33
Cardiac Sarcoidosis. ( 27443438 )
2016
34
Steroid Therapy Ameliorated Myocardial Fatty Acid Metabolism With Recovery of Complete Atrioventricular Block in Cardiac Sarcoidosis. ( 26973088 )
2016
35
A Diagnostic and Therapeutic Approach to Arrhythmias in Cardiac Sarcoidosis. ( 26874704 )
2016
36
Time Course and Factors Correlating With Ventricular Tachyarrhythmias After Introduction of Steroid Therapy in Cardiac Sarcoidosis. ( 27301264 )
2016
37
Cardiac sarcoidosis: the impact of age and implanted devices on survival. ( 27614001 )
2016
38
Presence of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Among Patients With Suspected Cardiac Sarcoidosis Is Associated With Adverse Cardiovascular Prognosis: A Systematic Review and Meta-Analysis. ( 27621357 )
2016
39
Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis. ( 27379608 )
2016
40
F-18 sodium fluoride PET/CT does not effectively image myocardial inflammation due to suspected cardiac sarcoidosis. ( 27197820 )
2016
41
Detecting Cardiac Sarcoidosis with a Right Atrial Mass Using Transthoracic Echocardiography. ( 26875960 )
2016
42
A dual tracer (68)Ga-DOTANOC PET/CT and (18)F-FDG PET/CT pilot study for detection of cardiac sarcoidosis. ( 27316444 )
2016
43
(18)F-fluoromisonidazole (FMISO) PET may have the potential to detect cardiac sarcoidosis. ( 27071998 )
2016
44
Diagnosis, therapeutic response assessment, and detection of disease recurrence in cardiac sarcoidosis: Integral role of cardiac PET. ( 26809438 )
2016
45
Cardiac sarcoidosis: An important niche for PET, but a journey just begun. ( 27506701 )
2016
46
Diagnosed late cardiac sarcoidosis in a patient with atrioventricular block. ( 27828755 )
2016
47
Evaluation of Known or Suspected Cardiac Sarcoidosis. ( 26926267 )
2016
48
Diagnostic value of speckle-tracking echocardiography in confirmed cardiac sarcoidosis. ( 27270760 )
2016
49
CMR imaging for follow up of isolated cardiac sarcoidosis with extensive biventricular involvement. ( 27428321 )
2016
50
Seeing Beyond the Obvious: Subclinical Cardiac Sarcoidosis Revealed by Cardiovascular Magnetic Resonance Mapping. ( 27903542 )
2016

Variations for Cardiac Sarcoidosis

Expression for Cardiac Sarcoidosis

Search GEO for disease gene expression data for Cardiac Sarcoidosis.

Pathways for Cardiac Sarcoidosis

GO Terms for Cardiac Sarcoidosis

Cellular components related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteasome complex GO:0000502 9.16 PSMB8 PSMB9
2 proteasome core complex GO:0005839 8.96 PSMB8 PSMB9
3 spermatoproteasome complex GO:1990111 8.62 PSMB8 PSMB9

Biological processes related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 LGALS3 PSMB8 PSMB9 TAP2
2 post-translational protein modification GO:0043687 9.63 PSMB8 PSMB9 TNC
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.5 PSMB8 PSMB9 TNF
4 NIK/NF-kappaB signaling GO:0038061 9.49 PSMB8 PSMB9
5 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.48 PSMB8 PSMB9
6 proteolysis involved in cellular protein catabolic process GO:0051603 9.43 PSMB8 PSMB9
7 regulation of cellular amino acid metabolic process GO:0006521 9.4 PSMB8 PSMB9
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.33 PSMB8 PSMB9 TAP2
9 positive regulation of podosome assembly GO:0071803 9.26 IL5 TNF
10 MAPK cascade GO:0000165 9.26 IL5 PSMB8 PSMB9 TNF
11 positive regulation of mononuclear cell migration GO:0071677 8.62 LGALS3 TNF

Molecular functions related to Cardiac Sarcoidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 threonine-type endopeptidase activity GO:0004298 8.62 PSMB8 PSMB9

Sources for Cardiac Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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