MCID: CRD137
MIFTS: 47

Cardiogenic Shock malady

Cardiovascular diseases category

Summaries for Cardiogenic Shock

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cardiogenic shock is based upon an inadequate circulation of blood due to primary failure of the... more...

MalaCards: Cardiogenic Shock, also known as shock, cardiogenic, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Cardiogenic Shock is HFE2 (hemochromatosis type 2 (juvenile)), and among its related pathways are Platelet activation, signaling and aggregation and PEDF Induced Signaling. The drugs inamrinone and digitoxin and the compounds aspartate and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Cardiogenic Shock

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48Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
cardiogenic shock:
Prevalence: 1-5/10000


Aliases & Descriptions:

cardiogenic shock 48
shock, cardiogenic 60


External Ids:

ICD10 via Orphanet26 R57.0
ICD1025 R57.0

Related Diseases for Cardiogenic Shock

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17GeneCards, 18GeneDecks
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Diseases related to Cardiogenic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.7SERPINE1, NOS1, PLAT, CD14, CRP, NPPB
2acute myocardial infarction31.5SERPINE1, NOS1, PLAT, CD14, CRP, NPPB
3myocarditis30.9NOS2, NPPB, MB
4coronary artery disease30.6SERPINE1, NOS1, PLAT, CD14, CRP, NPPB
5hepatitis30.4GPT, SOD2
6hypertension30.4SERPINE1, PLAT, CRP, NPPB
7hemochromatosis30.3HFE2
8dilated cardiomyopathy30.3NPPB, MB
9antiphospholipid syndrome30.3PLAT, APOH
10lupus erythematosus30.3APOH, IFNA2
11pulmonary embolism30.3PLAT, NPPB, APOH
12influenza30.3NOS1, MB, SOD2
13pneumonia30.3NOS1, IL10, CRP, MB
14systemic lupus erythematosus30.3IL1R1, IL1RN, IL10, CRP, APOH
15amyloidosis30.1CRP, NPPB
16kawasaki disease30.1GPT, CRP, NPPB
17myopathy30.1NOS1, GPT, CRP, MB
18hepatitis c30.1GPT, IL1R1, IL10, SOD2, IFNA2
19ischemia30.1NOS1, NOS2, PLAT, CD14, NPPB, MB
20diabetes mellitus30.0SERPINE1, PLAT, GPT, IL1R1, CD14, CRP
21atherosclerosis30.0SERPINE1, NOS1, NOS2, PLAT, IL1R1, IL1RN
22acute myocarditis10.6
23pheochromocytoma10.5
24coronary thrombosis10.4
25hypertrophic cardiomyopathy10.4
26inferior myocardial infarction10.4
27endocarditis10.4
28atrioventricular block10.3
29myxedema10.3
30coronary stenosis10.3
31cerebritis10.2
32myocardial stunning10.2
33churg-strauss syndrome10.2
34hepatitis a10.2
35aortic disease10.2
36aortic valve insufficiency10.2
37hypothyroidism10.2
38ventricular septal defect10.2
39cardiac tamponade10.1
40renovascular hypertension10.1
41intrahepatic cholestasis10.1
42pulmonary edema10.1
43hypophosphatemia10.1
44congenital hypothyroidism10.1
45transthyretin amyloidosis10.1
46panhypopituitarism10.1
47alcoholic cardiomyopathy10.1
48peripartum cardiomyopathy10.1
49anorexia nervosa10.1
50septal myocardial infarction10.1

Graphical network of the top 20 diseases related to Cardiogenic Shock:



Diseases related to cardiogenic shock

Clinical Features for Cardiogenic Shock

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Drugs & Therapeutics for Cardiogenic Shock

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cardiogenic Shock

Drug clinical trials:

Search ClinicalTrials for Cardiogenic Shock

Search NIH Clinical Center for Cardiogenic Shock

Search CenterWatch for Cardiogenic Shock

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cardiogenic Shock

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Anatomical Context for Cardiogenic Shock

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32MalaCards
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MalaCards organs/tissues related to Cardiogenic Shock:

32
Heart

Animal Models for Cardiogenic Shock or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cardiogenic Shock:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.0SERPINE1, IL1R1
2MP:000538810.0NOS1, MB, IL1R1
3MP:001077110.0HFE2, IL1R1, SOD2
4MP:00053909.8PLAT, CD14, NOS1
5MP:00053899.8IL1RN, HFE2, SOD2
6MP:00053699.6SOD1, MB, NPPB, NOS1
7MP:00020069.6IL1R1, IL10, NOS2
8MP:00053918.9PLAT, IL1R1, NPTX1, SOD1, SOD2, NOS1
9MP:00053768.5CRP, APOH, MB, SOD1, HFE2, CD14
10MP:00053708.2SOD1, SOD2, SERPINE1, NOS1, NOS2, IL1R1
11MP:00053787.6SERPINE1, SOD2, IL10, MB, CD14, IL1RN
12MP:00053877.6SOD2, SOD1, CRP, HFE2, SERPINE1, NOS1
13MP:00053847.5IL1R1, EPO, SOD1, SOD2, IL10, CAT
14MP:00053977.5HFE2, EPO, IL10, IL1RN, IL1R1, PLAT
15MP:00053857.1SERPINE1, SOD2, SOD1, MB, NPPB, CRP
16MP:00107686.9MB, SOD1, SOD2, APOH, HFE2, CD14

Publications for Cardiogenic Shock

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Genetic Variations for Cardiogenic Shock

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Expression for genes affiliated with Cardiogenic Shock

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiogenic Shock

Search GEO for disease gene expression data for Cardiogenic Shock.

Pathways for genes affiliated with Cardiogenic Shock

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore
See all sources

Pathways related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NOS1
2
Hide members
10.1SOD2, CD14
310.0PLAT, SERPINE1
4
Hide members
9.9NOS2, NOS1
59.8SOD1, CAT
69.8CD14, EPO, IL1R1
79.6SOD2, SOD1, CAT
89.6CAT, SOD1, SOD2
9
Immune response Bacterial infections in normal airways
Hide members
9.6NOS2, IL1R1, IL1RN, CD14
109.6NOS2, IL10, CD14
119.6EPO, SERPINE1, NOS2
12
Hide members
9.5CD14, SERPINE1, NOS2, IL1R1
13
Hide members
9.5SOD1, NOS1, CAT
14
Hide members
9.5NOS2, SOD1, CAT
15
CFTR folding and maturation (norm and CF)
9.5NOS2, NOS1, SOD1
169.4IL1R1, NOS2, IL10, CD14
179.3NOS2, CD14, IL10, IFNA2
189.3NOS2, SOD2, CAT, SOD1
19
Hide members
9.1SERPINE1, IL10, CD14, IFNA2, NOS2
208.9SOD2, CAT, SOD1, CRP, PLAT, SERPINE1

Compounds for genes affiliated with Cardiogenic Shock

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 300)
idCompoundScoreTop Affiliating Genes
1aspartate4410.5CD14, GPT
2endotoxin4410.4APOH, SERPINE1
3cycloheximide4410.4SOD2, CAT
4norepinephrine44 11 2412.4MB
5alpha tocopherol4410.3SOD2, IFNA2, APOH
6superoxide44 2411.2APOH, NOS1, IFNA2
7uric acid44 2411.1IL1R1, NPPB, APOH, SERPINE1
8p0034410.0PLAT, NPPB, SERPINE1, APOH
9indomethacin44 59 28 1113.0NOS1, NPPB, IL1R1, PLAT
10vitamin a44 11 2411.9IFNA2, SOD2, MB, CAT
11cyclosporin a44 28 5911.8GPT, NOS1, IL1R1, CD14, NPPB
12oxygen44 2410.7EPO, MB, NOS2, NOS1
13cyclophosphamide44 49 1111.7APOH, CRP, IL1R1, NPPB, IFNA2, SOD2
14polysulfone449.6IL1RN, IL1R1, EPO, CD14
15prednisolone44 28 1111.5IFNA2, MB, APOH, NPPB, CRP, CD14
16vitamin d449.5NPPB, IL10, CD14, SOD2, IL1R1, GPT
17heparin44 28 11 2412.4IL1RN, MB, APOH, NPTX1, CD14, IL1R1
18etanercept44 49 1111.3IFNA2, IL1R1, IL1RN, IL10, CRP, APOH
19homocysteine44 2410.3APOH, CRP, NPPB, IL1R1, PLAT, CD14
20p002449.3GPT, IL1RN, CD14, CRP, NPPB, PLAT
21infliximab44 49 1111.3IL1RN, IL10, CRP, IL1R1, APOH, IFNA2
22ivig449.3CRP, APOH, IL1R1, GPT, IL1RN, IL10
23allopurinol44 49 1111.3CAT, NOS1, SOD2, NPPB, IFNA2, SOD1
24aprotinin44 1110.2MB, NPPB, EPO, PLAT, SERPINE1
25neopterin449.2GPT, IL1R1, IL10, CRP, CD14, IFNA2
26fluvastatin44 49 28 1112.2SERPINE1, NOS2, PLAT, GPT, CRP, MB
27l-nmma449.1CAT, SOD1, NPPB, NOS2, NOS1, IL1RN
28malondialdehyde449.1APOH, SOD1, SOD2, CAT, EPO, GPT
29peroxynitrite449.0SOD2, NOS1, NOS2, CAT, APOH, SOD1
30nitroglycerin44 1110.0SOD1, NOS2, PLAT, NPPB, CRP, NOS1
318-isoprostane449.0IL10, CRP, NPPB, APOH, SOD1, SERPINE1
32atorvastatin44 49 28 11 2413.0IL10, SERPINE1, PLAT, GPT, IL1RN, CRP
33betacarotene449.0APOH, CRP, SOD1, IL10, SOD2, IFNA2
34iron44 2410.0MB, CAT, IFNA2, SOD2, APOH, NPPB
35enalapril44 49 1110.9PLAT, EPO, IL10, SERPINE1, NPPB
36fibrinogen448.9IL1RN, CD14, IL1R1, PLAT, GPT, SERPINE1
37n acetylcysteine448.7NOS2, GPT, IL1R1, CAT, SOD2, SOD1
38prostacyclin448.6SOD1, SERPINE1, NOS2, PLAT, IL10, CRP
39sodium nitroprusside448.5CAT, SOD2, SOD1, MB, NPPB, PLAT
40creatinine448.5CRP, NPPB, APOH, MB, SOD1, CD14
41sb 20358044 599.5SERPINE1, CAT, IL1RN, CRP, IL1R1, NPPB
424-hydroxynonenal44 249.4SOD1, MB, IL10, NOS2, CAT, SOD2
43methotrexate44 49 1110.4APOH, CRP, EPO, IL10, IL1RN, IL1R1
44arginine448.2NOS1, CD14, MB, APOH, IL1R1, GPT
45cysteine448.0NOS1, SOD2, CAT, IFNA2, MB, SOD1
46lipid448.0SERPINE1, GPT, IL1R1, SOD1, CAT, IFNA2
47nitric oxide44 11 249.9NOS1, CAT, SERPINE1, SOD2, IL10, SOD1
48ascorbic acid44 248.8SOD1, MB, CRP, EPO, IL1RN, IL1R1
49lactate447.7GPT, IL1R1, CRP, CD14, EPO, IL1RN
50vegf447.0NOS2, IL1R1, IL1RN, IL10, EPO, CD14

GO Terms for genes affiliated with Cardiogenic Shock

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16Gene Ontology
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Cellular components related to Cardiogenic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.4SERPINE1, PLAT, APOH, SOD1
2cell surfaceGO:0099869.1PLAT, IL1R1, EPO, CD14, HFE2, APOH
3extracellular regionGO:0055767.9SERPINE1, PLAT, IL1R1, EPO, CD14, CRP
4extracellular spaceGO:0056157.5HFE2, CRP, APOH, CD14, EPO, IL10

Biological processes related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.2PLAT, APOH
2peptidyl-cysteine S-nitrosylationGO:01811910.2NOS1, NOS2
3response to superoxideGO:00030310.1SOD1, SOD2
4positive regulation of guanylate cyclase activityGO:03128410.1NOS2, NOS1
5negative regulation of calcium ion transport into cytosolGO:01052310.1EPO, NOS1
6negative regulation of fibrinolysisGO:05191810.1APOH, SERPINE1
7response to hydrogen peroxideGO:04254210.0SOD2, SOD1, MB
8response to hyperoxiaGO:05509310.0EPO, SOD2, CAT
9cell surface receptor signaling pathwayGO:00716610.0IL1R1, CD14, NPPB, IFNA2
10arginine catabolic processGO:00652710.0NOS1, NOS2
11hydrogen peroxide biosynthetic processGO:05066510.0SOD1, SOD2
12superoxide metabolic processGO:0068019.9NOS2, SOD1, SOD2
13response to heatGO:0094089.9SOD1, CD14, NOS1
14regulation of blood pressureGO:0082179.9SOD2, SOD1, NPPB
15response to axon injuryGO:0486789.9EPO, SOD1, SOD2
16removal of superoxide radicalsGO:0194309.8SOD1, SOD2
17positive regulation of blood coagulationGO:0301949.8SERPINE1, APOH
18response to glucocorticoid stimulusGO:0513849.7PLAT, IL1RN, IL10
19cellular response to lipopolysaccharideGO:0712229.7CD14, IL10, NOS2, SERPINE1
20inflammatory responseGO:0069549.4IFNA2, CRP, CD14, IL10, NOS2
21response to drugGO:0424939.3IL1RN, IL10, SOD1, SOD2
22blood coagulationGO:0075969.1IFNA2, SOD1, PLAT, NOS2, NOS1, SERPINE1
23response to hypoxiaGO:0016669.0NOS1, CAT, SOD2, MB, CRP, PLAT

Molecular functions related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.0NOS1, NOS2
2tetrahydrobiopterin bindingGO:0346179.9NOS1, NOS2
3arginine bindingGO:0346189.9NOS2, NOS1
4superoxide dismutase activityGO:0047849.8SOD2, SOD1
5NADP bindingGO:0506619.7NOS2, NOS1, CAT
6NADPH-hemoprotein reductase activityGO:0039589.6NOS2, NOS1
7heme bindingGO:0200379.6NOS1, CAT, MB, NOS2
8receptor bindingGO:0051029.4SERPINE1, CAT, NPPB, NOS2

Products for genes affiliated with Cardiogenic Shock

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiogenic Shock

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet