MCID: CRD137
MIFTS: 56

Cardiogenic Shock malady

Cardiovascular category

Summaries for Cardiogenic Shock

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cardiogenic shock is based upon an inadequate circulation of blood due to primary failure of the... more...

MalaCards: Cardiogenic Shock, also known as shock, cardiogenic, is related to acute myocardial infarction and coronary artery disease,. An important gene associated with Cardiogenic Shock is HFE2 (hemochromatosis type 2 (juvenile)), and among its related pathways are Platelet activation, signaling and aggregation and PEDF Induced Signaling. The drugs digitoxin and digoxin and the compounds aspartate and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Cardiogenic Shock

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Characteristics (Orphanet epidemiological data):

49
cardiogenic shock:
Prevalence: 1-5/10000


Aliases & Descriptions:

cardiogenic shock 49
shock, cardiogenic 61


External Ids:

ICD10 via Orphanet26 R57.0
ICD1025 R57.0

Related Diseases for Cardiogenic Shock

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cardiogenic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 297)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.6SERPINE1, NOS1, PLAT, CD14, CRP, NPPB
2coronary artery disease,30.6SERPINE1, NOS1, PLAT, CD14, CRP, NPPB
3septic shock30.6SERPINE1, NOS2, IL1R1, IL1RN, IL10, CD14
4hemochromatosis30.3HFE2
5antiphospholipid syndrome30.3PLAT, APOH
6hepatitis c30.3GPT, IL1R1, IL10, SOD2, IFNA2
7systemic lupus erythematosus30.3IL1R1, IL1RN, IL10, CRP, APOH
8amyloidosis30.1CRP, NPPB
9kawasaki disease30.1GPT, CRP, NPPB
10coronary heart disease30.1SERPINE1, PLAT, CRP, NPPB, MB
11hepatitis b30.1GPT, IL10, IFNA2, CAT
12sepsis30.1SERPINE1, NOS2, IL1R1, IL1RN, IL10, CD14
13atherosclerosis30.1SERPINE1, NOS1, NOS2, PLAT, IL1R1, IL1RN
14acute myocarditis10.6
15left ventricular outflow tract obstruction10.6
16pheochromocytoma10.5
17tako-tsubo cardiomyopathy10.5
18coronary thrombosis10.4
19hypertrophic cardiomyopathy10.4
20inferior myocardial infarction10.4
21atrioventricular block10.3
22myxedema10.3
23myocardial stunning10.2
24churg-strauss syndrome10.2
25hepatitis a10.2
26aortic disease10.2
27aortic valve insufficiency10.2
28ventricular septal defect10.2
29stress cardiomyopathy10.2
30catastrophic antiphospholipid syndrome10.2
31myocardial infarction 210.2
32cardiac tamponade10.1
33renovascular hypertension10.1
34intrahepatic cholestasis10.1
35pulmonary edema10.1
36hypophosphatemia10.1
37congenital hypothyroidism10.1
38transthyretin amyloidosis10.1
39panhypopituitarism10.1
40takayasu's arteritis10.1
41peripartum cardiomyopathy10.1
42anorexia nervosa10.1
43septal myocardial infarction10.1
44anterolateral myocardial infarction10.1
45n syndrome10.1
46phaeochromocytoma10.1
47beriberi10.1
48propionic acidemia10.1
49constrictive pericarditis10.1
50thymoma10.1

Graphical network of the top 20 diseases related to Cardiogenic Shock:



Diseases related to cardiogenic shock

Clinical Features for Cardiogenic Shock

Drugs & Therapeutics for Cardiogenic Shock

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cardiogenic Shock

Drug clinical trials:

Search ClinicalTrials for Cardiogenic Shock

Search NIH Clinical Center for Cardiogenic Shock

Search CenterWatch for Cardiogenic Shock

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cardiogenic Shock

Anatomical Context for Cardiogenic Shock

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cardiogenic Shock:

33
Heart, Kidney, Liver, Lung, Breast, Prostate, Monocytes, T cells, B cells, Tongue, Pituitary

Animal Models for Cardiogenic Shock or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cardiogenic Shock

Sources:
51PubMed
See all sources

Articles related to Cardiogenic Shock:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock. (23982033)
2014
2
Anesthetic and hemodynamic management of a rare case of Brucella multivalvular endocarditis in cardiogenic shock undergoing emergency aortic valve replacement and mitral valve repair. (24107698)
2013
3
Sotalol-associated cardiogenic shock in a patient with asymptomatic transient rate-related cardiomyopathy. (24237089)
2013
4
Percutaneous left-ventricular support with the Impella-2.5-assist device in acute cardiogenic shock: results of the Impella-EUROSHOCK-registry. (23212552)
2013
5
Temporary left ventricular stimulation in patients with refractory cardiogenic shock and asynchronous left ventricular contraction: a safety and feasibility study. (22982965)
2013
6
Acute intraventricular thrombosis of an impella LP 5.0 device in an ST-elevated myocardial infarction complicated by cardiogenic shock. (23293180)
2013
7
Additive effect of propofol and fentanyl precipitating cardiogenic shock. (23960431)
2013
8
The effectiveness of inodilators in reducing short term mortality among patient with severe cardiogenic shock: a propensity-based analysis. (23977106)
2013
9
Routine pretreatment with abciximab versus standard periprocedural therapy in mechanically ventilated cardiogenic shock patients undergoing primary percutaneous coronary intervention: Subanalysis of the PRAGUE-7 study. (23940425)
2013
10
Reversible cardiogenic shock caused by atrioventricular junctional rhythm after percutaneous coronary intervention. (23097662)
2012
11
Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation. (22990851)
2012
12
Extracorporeal membrane oxygenation in maternal arrhythmic cardiogenic shock. (21641147)
2012
13
Continuous levosimendan infusion for refractory cardiogenic shock complicating severe acute dichlorvos poisoning. (22771967)
2012
14
Evidence for overturning the guidelines in cardiogenic shock. (22920913)
2012
15
Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock. (22212516)
2012
16
Intraaortic balloon support for myocardial infarction with cardiogenic shock. (22920912)
2012
17
Unilateral pulmonary edema: a rare initial presentation of cardiogenic shock due to acute myocardial infarction. (22323871)
2012
18
Extracorporeal membrane oxygenation-assisted primary percutaneous coronary intervention may improve survival of patients with acute myocardial infarction complicated by profound cardiogenic shock. (22591567)
2012
19
New therapies for cardiogenic shock. (22322578)
2012
20
Percutaneous transcatheter closure of the aortic valve to treat cardiogenic shock in a left ventricular assist device patient with severe aortic insufficiency. (22916753)
2012
21
Cardiogenic shock in an elderly man caused by left main coronary artery occlusion with spontaneous dissection of right coronary artery. (21152670)
2011
22
Evaluation and management of shock States: hypovolemic, distributive, and cardiogenic shock. (21507874)
2011
23
Single-center experience with treatment of cardiogenic shock in children by pediatric ventricular assist devices. (21335121)
2011
24
Left ventricular support device for cardiogenic shock during myocardial infarction due to stent thrombosis: a single centre experience. (20034686)
2011
25
Cardiogenic shock complicating acute myocardial infarction--a review. (22299378)
2011
26
Mechanical bridge to decision: what are the options for the management of acute refractory cardiogenic shock? (21161450)
2011
27
Shoshin beriberi mimicking a high-risk non-ST-segment elevation acute coronary syndrome with cardiogenic shock: when the arteries are not guilty. (18930369)
2011
28
Cardiogenic shock. (22118117)
2011
29
Peripheral extracorporeal membrane oxygenation: a useful option to allow recovery in acute cardiogenic shock. (21796060)
2011
30
Successful bridge to recovery using a microaxial blood pump in a patient with electrical storm and cardiogenic shock. (22038638)
2011
31
Immediate cardiac arrest and subsequent development of cardiogenic shock caused by lightning strike. (20065746)
2010
32
Coupled plasma filtration adsorption reduces serum bilirubine in a case of acute hypoxic hepatitis secondary to cardiogenic shock. (21058270)
2010
33
Current and future perspectives in cardiogenic shock, reperfusion strategies and hemodynamic inotropic support for acute heart failure. (20201655)
2010
34
Effect of multivessel coronary disease with or without concurrent chronic total occlusion on one-year mortality in patients treated with primary percutaneous coronary intervention for cardiogenic shock. (20346312)
2010
35
Predictors and in-hospital outcomes of cardiogenic shock on admission in patients with acute coronary syndromes admitted to hospitals without on-site invasive facilities. (20201656)
2010
36
Heart and kidney: the cardiorenal syndrome in cardiogenic shock. (20083931)
2010
37
Commentary: successful combined use of the Impella Recover 2.5 device and intraaortic balloon pump support for cardiogenic shock after acute myocardial infarction. (21245797)
2010
38
Use of the AB5000 ventricular assist device in cardiogenic shock after acute myocardial infarction. (20732481)
2010
39
Successful extracorporeal membrane oxygenation for refractory cardiogenic shock due to the catastrophic antiphospholipid syndrome. (20921559)
2010
40
Catastrophic antiphospholipid syndrome complicated by cardiogenic shock - a case report]. (19650000)
2009
41
Coronary artery bypass graft surgery provides better survival in patients with acute coronary syndrome or ST-segment elevation myocardial infarction experiencing cardiogenic shock after percutaneous coronary intervention: a propensity score analysis. (19660378)
2009
42
Levitronix CentriMag to Berlin Heart Excor: a "bridge to bridge" solution in refractory cardiogenic shock. (19672191)
2009
43
Emergent coronary artery bypass grafting for cardiogenic shock caused by very late drug-eluting stent thrombosis. (19908116)
2009
44
Evaluating percutaneous support for cardiogenic shock: data shock and sticker shock. (19622514)
2009
45
Rapid onset and resolution of cardiogenic shock in a patient with pheochromocytoma. (19522966)
2009
46
Gender differences in patients with acute ST-elevation myocardial infarction complicated by cardiogenic shock. (19856196)
2009
47
Dynamic left ventricular outflow tract obstruction: an unusual mechanism mimicking anterior myocardial infarction with cardiogenic shock. (11214704)
2001
48
CD14 expression on monocytes and TNF alpha production in patients with septic shock, cardiogenic shock or bacterial pneumonia. (11219189)
2001
49
Extracorporeal membrane oxygenation in treatment of cardiogenic shock caused by acute myocarditis. (9610063)
1998
50
Role of right ventricular infarction in cardiogenic shock associated with inferior myocardial infarction. (534590)
1979

Genetic Variations for Cardiogenic Shock

Expression for genes affiliated with Cardiogenic Shock

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cardiogenic Shock

Search GEO for disease gene expression data for Cardiogenic Shock.

Pathways for genes affiliated with Cardiogenic Shock

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 50PharmGKB, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NOS1
2
Hide members
10.1CD14, SOD2
310.0SERPINE1, PLAT
4
Hide members
9.9NOS1, NOS2
59.8SOD1, CAT
69.8IL1R1, EPO, CD14
79.6CAT, SOD2, SOD1
89.6SOD1, SOD2, CAT
9
Immune response Bacterial infections in normal airways
Hide members
9.6NOS2, IL1R1, IL1RN, CD14
109.6CD14, IL10, NOS2
119.6SERPINE1, NOS2, EPO
12
Hide members
9.5SERPINE1, NOS2, IL1R1, CD14
13
Hide members
9.5CAT, SOD1, NOS1
14
Hide members
9.5CAT, SOD1, NOS2
15
CFTR folding and maturation (norm and CF)
9.5SOD1, NOS2, NOS1
169.4CD14, IL10, IL1R1, NOS2
179.3NOS2, IL10, CD14, IFNA2
189.3CAT, SOD2, SOD1, NOS2
19
Hide members
9.1SERPINE1, NOS2, IL10, CD14, IFNA2
208.9SERPINE1, PLAT, CRP, SOD1, SOD2, CAT

Compounds for genes affiliated with Cardiogenic Shock

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 300)
idCompoundScoreTop Affiliating Genes
1aspartate4510.5CD14, GPT
2endotoxin4510.4APOH, SERPINE1
3cycloheximide4510.4SOD2, CAT
4norepinephrine45 11 2412.4MB
5alpha tocopherol4510.3SOD2, IFNA2, APOH
6superoxide45 2411.2APOH, NOS1, IFNA2
7uric acid45 2411.1IL1R1, NPPB, APOH, SERPINE1
8p0034510.0PLAT, NPPB, SERPINE1, APOH
9indomethacin45 60 29 1113.0NOS1, NPPB, IL1R1, PLAT
10vitamin a45 11 2411.9IFNA2, SOD2, MB, CAT
11cyclosporin a45 29 6011.8GPT, NOS1, IL1R1, CD14, NPPB
12oxygen45 2410.7EPO, MB, NOS2, NOS1
13cyclophosphamide45 50 1111.7APOH, CRP, IL1R1, NPPB, IFNA2, SOD2
14polysulfone459.6IL1RN, IL1R1, EPO, CD14
15prednisolone45 29 1111.5IFNA2, MB, APOH, NPPB, CRP, CD14
16vitamin d459.5NPPB, IL10, CD14, SOD2, IL1R1, GPT
17heparin45 29 11 2412.4IL1RN, MB, APOH, NPTX1, CD14, IL1R1
18etanercept45 50 1111.3IFNA2, IL1R1, IL1RN, IL10, CRP, APOH
19homocysteine45 2410.3APOH, CRP, NPPB, IL1R1, PLAT, CD14
20p002459.3GPT, IL1RN, CD14, CRP, NPPB, PLAT
21infliximab45 50 1111.3IL1RN, IL10, CRP, IL1R1, APOH, IFNA2
22ivig459.3CRP, APOH, IL1R1, GPT, IL1RN, IL10
23allopurinol45 50 1111.3CAT, NOS1, SOD2, NPPB, IFNA2, SOD1
24aprotinin45 1110.2MB, NPPB, EPO, PLAT, SERPINE1
25neopterin459.2GPT, IL1R1, IL10, CRP, CD14, IFNA2
26fluvastatin45 50 29 1112.2SERPINE1, NOS2, PLAT, GPT, CRP, MB
27l-nmma459.1CAT, SOD1, NPPB, NOS2, NOS1, IL1RN
28malondialdehyde459.1APOH, SOD1, SOD2, CAT, EPO, GPT
29peroxynitrite459.0SOD2, NOS1, NOS2, CAT, APOH, SOD1
30nitroglycerin45 1110.0SOD1, NOS2, PLAT, NPPB, CRP, NOS1
318-isoprostane459.0IL10, CRP, NPPB, APOH, SOD1, SERPINE1
32atorvastatin45 50 29 11 2413.0IL10, SERPINE1, PLAT, GPT, IL1RN, CRP
33betacarotene459.0APOH, CRP, SOD1, IL10, SOD2, IFNA2
34iron45 2410.0MB, CAT, IFNA2, SOD2, APOH, NPPB
35enalapril45 50 1110.9PLAT, EPO, IL10, SERPINE1, NPPB
36fibrinogen458.9IL1RN, CD14, IL1R1, PLAT, GPT, SERPINE1
37n acetylcysteine458.7NOS2, GPT, IL1R1, CAT, SOD2, SOD1
38prostacyclin458.6SOD1, SERPINE1, NOS2, PLAT, IL10, CRP
39sodium nitroprusside458.5CAT, SOD2, SOD1, MB, NPPB, PLAT
40creatinine458.5CRP, NPPB, APOH, MB, SOD1, CD14
41sb 20358045 609.5SERPINE1, CAT, IL1RN, CRP, IL1R1, NPPB
424-hydroxynonenal45 249.4SOD1, MB, IL10, NOS2, CAT, SOD2
43methotrexate45 50 1110.4APOH, CRP, EPO, IL10, IL1RN, IL1R1
44arginine458.2NOS1, CD14, MB, APOH, IL1R1, GPT
45cysteine458.0NOS1, SOD2, CAT, IFNA2, MB, SOD1
46lipid458.0SERPINE1, GPT, IL1R1, SOD1, CAT, IFNA2
47nitric oxide45 11 249.9NOS1, CAT, SERPINE1, SOD2, IL10, SOD1
48ascorbic acid45 248.8SOD1, MB, CRP, EPO, IL1RN, IL1R1
49lactate457.7GPT, IL1R1, CRP, CD14, EPO, IL1RN
50vegf457.0NOS2, IL1R1, IL1RN, IL10, EPO, CD14

GO Terms for genes affiliated with Cardiogenic Shock

Sources:
16Gene Ontology
See all sources

Cellular components related to Cardiogenic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.4SERPINE1, PLAT, APOH, SOD1
2cell surfaceGO:0099869.1APOH, HFE2, CD14, EPO, IL1R1, PLAT
3extracellular regionGO:0055767.9IFNA2, SOD1, NPPB, CRP, CD14, EPO
4extracellular spaceGO:0056157.5SERPINE1, IFNA2, SOD1, APOH, NPPB, CRP

Biological processes related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.2PLAT, APOH
2peptidyl-cysteine S-nitrosylationGO:01811910.2NOS1, NOS2
3response to superoxideGO:00030310.1SOD1, SOD2
4positive regulation of guanylate cyclase activityGO:03128410.1NOS2, NOS1
5negative regulation of calcium ion transport into cytosolGO:01052310.1EPO, NOS1
6negative regulation of fibrinolysisGO:05191810.1APOH, SERPINE1
7response to hydrogen peroxideGO:04254210.0SOD2, SOD1, MB
8response to hyperoxiaGO:05509310.0EPO, SOD2, CAT
9cell surface receptor signaling pathwayGO:00716610.0IL1R1, CD14, NPPB, IFNA2
10arginine catabolic processGO:00652710.0NOS1, NOS2
11hydrogen peroxide biosynthetic processGO:05066510.0SOD1, SOD2
12superoxide metabolic processGO:0068019.9NOS2, SOD1, SOD2
13response to heatGO:0094089.9SOD1, CD14, NOS1
14regulation of blood pressureGO:0082179.9SOD2, SOD1, NPPB
15response to axon injuryGO:0486789.9EPO, SOD1, SOD2
16removal of superoxide radicalsGO:0194309.8SOD1, SOD2
17positive regulation of blood coagulationGO:0301949.8SERPINE1, APOH
18response to glucocorticoid stimulusGO:0513849.7PLAT, IL1RN, IL10
19cellular response to lipopolysaccharideGO:0712229.7CD14, IL10, NOS2, SERPINE1
20inflammatory responseGO:0069549.4IFNA2, CRP, CD14, IL10, NOS2
21response to drugGO:0424939.3IL1RN, IL10, SOD1, SOD2
22blood coagulationGO:0075969.1IFNA2, SOD1, PLAT, NOS2, NOS1, SERPINE1
23response to hypoxiaGO:0016669.0NOS1, CAT, SOD2, MB, CRP, PLAT

Molecular functions related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.0NOS1, NOS2
2arginine bindingGO:0346189.9NOS2, NOS1
3tetrahydrobiopterin bindingGO:0346179.9NOS2, NOS1
4superoxide dismutase activityGO:0047849.8SOD1, SOD2
5NADP bindingGO:0506619.7CAT, NOS2, NOS1
6NADPH-hemoprotein reductase activityGO:0039589.6NOS2, NOS1
7heme bindingGO:0200379.6NOS1, NOS2, MB, CAT
8receptor bindingGO:0051029.4SERPINE1, NOS2, NPPB, CAT

Products for genes affiliated with Cardiogenic Shock

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiogenic Shock

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet