MCID: CRD137
MIFTS: 48

Cardiogenic Shock malady

Rare diseases, Cardiovascular diseases categories

Summaries for Cardiogenic Shock

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66Wikipedia, 34MalaCards
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Wikipedia:66 Cardiogenic shock is based upon an inadequate circulation of blood due to primary failure of the... more...

MalaCards: Cardiogenic Shock, also known as shock, cardiogenic, is related to acute myocardial infarction and septic shock. An important gene associated with Cardiogenic Shock is HFE2 (hemochromatosis type 2 (juvenile)), and among its related pathways are Amoebiasis and TRAF Pathway. The drugs digitoxin and digoxin and the compounds gold sodium thiomalate and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and kidney.

Aliases & Classifications for Cardiogenic Shock

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Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

50
cardiogenic shock:
Prevalence: 1-5/10000


Aliases & Descriptions:

cardiogenic shock 50
shock, cardiogenic 63


External Ids:

ICD10 via Orphanet27 R57.0
ICD1026 R57.0

Related Diseases for Cardiogenic Shock

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Cardiogenic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.5NPPB, CD14
2septic shock30.6CD14, NPPB, IL1R1
3pulmonary embolism30.4NPPB, APOH
4lupus erythematosus30.4IFNA2, APOH
5atherosclerosis30.1CD14, IL1R1, APOH
6sepsis30.1IL1R1, NPPB, CD14
7diabetes mellitus30.1CD14, NPPB, IL1R1
8myocardial infarction11.2
9myocarditis10.7
10left ventricular outflow tract obstruction10.6
11pheochromocytoma10.5
12coronary artery disease10.5
13acute myocarditis10.5
14artery disease10.5
15inferior myocardial infarction10.4
16endocarditis10.4
17atrioventricular block10.3
18hypertrophic cardiomyopathy10.3
19hepatitis10.3
20hypertension10.3
21antiphospholipid syndrome10.3
22hemochromatosis10.3
23myxedema10.3
24myocardial stunning10.3
25churg-strauss syndrome10.3
26cerebritis10.3
27systemic lupus erythematosus10.3
28dilated cardiomyopathy10.3
29hypothyroidism10.3
30influenza10.3
31pneumonia10.3
32ventricular septal defect10.3
33catastrophic antiphospholipid syndrome10.3
34cardiac tamponade10.1
35hepatitis c10.1
36intrahepatic cholestasis10.1
37renovascular hypertension10.1
38panhypopituitarism10.1
39peripheral artery disease10.1
40peripartum cardiomyopathy10.1
41coronary thrombosis10.1
42anorexia nervosa10.1
43beriberi10.1
44propionic acidemia10.1
45constrictive pericarditis10.1
46pulmonary edema10.1
47hypophosphatemia10.1
48congenital hypothyroidism10.1
49anterolateral myocardial infarction10.1
50phaeochromocytoma10.1

Graphical network of the top 20 diseases related to Cardiogenic Shock:



Diseases related to cardiogenic shock

Symptoms for Cardiogenic Shock

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Drugs & Therapeutics for Cardiogenic Shock

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cardiogenic Shock

Drug clinical trials:

Search ClinicalTrials for Cardiogenic Shock

Search NIH Clinical Center for Cardiogenic Shock

Search CenterWatch for Cardiogenic Shock

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cardiogenic Shock

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Anatomical Context for Cardiogenic Shock

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Sources:
34MalaCards
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MalaCards organs/tissues related to Cardiogenic Shock:

34
Heart, Liver, Kidney, Monocytes, Lung, Breast, Prostate, Tongue, Pituitary

Animal Models for Cardiogenic Shock or affiliated genes

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Publications for Cardiogenic Shock

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Sources:
53PubMed
See all sources

Articles related to Cardiogenic Shock:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Wretched excess: stool-softener abuse and cardiogenic shock. (23968901)
2013
2
Levosimendan for the treatment of subarachnoid hemorrhage-related cardiogenic shock. (23673402)
2013
3
A new approach for early onset cardiogenic shock in acute colchicine overdose: place of early extracorporeal life support (ECLS)? (23612758)
2013
4
BET 3: evaluation of intra-aortic balloon support in cardiogenic shock. (24232009)
2013
5
Cardiogenic shock. (24188221)
2013
6
Intraaortic balloon support for cardiogenic shock. (23281984)
2013
7
Post myocardial infarction cardiogenic shock: a review of current therapies. (21747126)
2013
8
Cardiovascular outcomes using intra-aortic balloon pump in high-risk acute myocardial infarction with or without cardiogenic shock: a meta-analysis. (21335478)
2012
9
Balloon pump support for cardiogenic shock after AMI. (23099571)
2012
10
Intra-aortic balloon support for MI and cardiogenic shock--time to change the guidelines? (22965109)
2012
11
Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock. (22386227)
2012
12
What is the evidence for IABP in STEMI with and without cardiogenic shock? (22569335)
2012
13
Repairing a "broken heart" with hormone replacement therapy: case report of cardiogenic shock due to undiagnosed pituitary insufficiency. (22138080)
2012
14
Intra-aortic balloon counterpulsation in the treatment of infarction-related cardiogenic shock--review of the current evidence. (22607158)
2012
15
Cardiogenic shock and awe. (22378244)
2012
16
Role of receptor for advanced glycation end products in cardiogenic shock. (22430238)
2012
17
Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial. (22709745)
2012
18
Emergency surgery for native mitral valve endocarditis: the impact of septic and cardiogenic shock. (22342063)
2012
19
Aorto-right atrial fistula secondary to infective endocarditis presenting with cardiogenic shock. (21045716)
2012
20
Successful use of a percutaneous miniaturized extracorporeal life support system as a bridge and assistance to left ventricular assist device implantation in a patient with severe refractory cardiogenic shock. (21859786)
2012
21
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
22
Cardiogenic shock in an elderly man caused by left main coronary artery occlusion with spontaneous dissection of right coronary artery. (21152670)
2011
23
Impella assisted transradial coronary intervention in patients with acute coronary syndromes and cardiogenic shock: case series. (21523889)
2011
24
The ability to achieve complete revascularization is associated with improved in-hospital survival in cardiogenic shock due to myocardial infarction: Manitoba cardiogenic SHOCK Registry investigators. (21547996)
2011
25
Defining refractory myocardial infarction-associated cardiogenic shock: an ongoing elusive challenge. (21248538)
2011
26
Evaluation and management of shock States: hypovolemic, distributive, and cardiogenic shock. (21507874)
2011
27
Hypothermia in cardiogenic shock reduces systemic t-PA release. (21190125)
2011
28
Cardiogenic shock due to dynamic left ventricular outflow tract obstruction in acute myocardial infarction. (21452037)
2011
29
Posterior ventricular septal defect in presence of cardiogenic shock: early implantation of the impella recover LP 5.0 as a bridge to surgery. (21423467)
2011
30
Mechanical versus pharmacologic support for cardiogenic shock. (20049971)
2010
31
Immediate cardiac arrest and subsequent development of cardiogenic shock caused by lightning strike. (20065746)
2010
32
Early extracorporeal membrane oxygenator-assisted primary percutaneous coronary intervention improved 30-day clinical outcomes in patients with ST-segment elevation myocardial infarction complicated with profound cardiogenic shock. (20543669)
2010
33
Intraoperative pulseless electrical activity and acute cardiogenic shock after administration of phenylephrine, epinephrine, and ketamine. (21603379)
2010
34
Acute kidney injury in ST-segment elevation acute myocardial infarction complicated by cardiogenic shock at admission. (19789449)
2010
35
Case series: CT scan in cardiac arrest and imminent cardiogenic shock. (20607032)
2010
36
Reversible cardiogenic shock in hypertrophic cardiomyopathy after alcohol septal ablation. (21074128)
2010
37
Combined use of Impella device and intra-aortic balloon pump to improve survival in a patient in profound cardiogenic shock post cardiac arrest. (19521993)
2009
38
Catastrophic antiphospholipid syndrome complicated by cardiogenic shock - a case report]. (19650000)
2009
39
Percutaneous left ventricular assist devices during cardiogenic shock and high-risk percutaneous coronary interventions. (19709497)
2009
40
The use of extracorporeal membrane oxygenation in patients with therapy refractory cardiogenic shock as a bridge to implantable left ventricular assist device and perioperative right heart support. (19894089)
2009
41
Clinical significance of post-procedural TIMI flow in patients with cardiogenic shock undergoing primary percutaneous coronary intervention. (19463399)
2009
42
Coronary artery bypass graft surgery provides better survival in patients with acute coronary syndrome or ST-segment elevation myocardial infarction experiencing cardiogenic shock after percutaneous coronary intervention: a propensity score analysis. (19660378)
2009
43
Contemporary management of cardiogenic shock: age is opportunity. (19463418)
2009
44
Cardiogenic shock without flow-limiting angiographic coronary artery disease: (from the Should We Emergently Revascularize Occluded Coronary Arteries for Cardiogenic Shock Trial and Registry). (19576316)
2009
45
Usefulness of intra-aortic balloon pump counterpulsation in patients with cardiogenic shock from acute myocardial infarction. (19616662)
2009
46
Images in cardiology: Acute adrenal insufficiency complicated by cardiogenic shock. (15772180)
2005
47
Comparative study of artificial circulation for the liver after cardiogenic shock: pulsatile or nonpulsatile?]. (9884562)
1998
48
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
49
Role of right ventricular infarction in cardiogenic shock associated with inferior myocardial infarction. (534590)
1979
50
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969

Variations for Cardiogenic Shock

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Expression for genes affiliated with Cardiogenic Shock

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cardiogenic Shock

Search GEO for disease gene expression data for Cardiogenic Shock.

Pathways for genes affiliated with Cardiogenic Shock

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Sources:
51PathCards, 31KEGG, 54QIAGEN, 61Thomson Reuters, 55R&D Systems
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Pathways related to Cardiogenic Shock according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD14, IL1R1
2
Show member pathways
9.4CD14, IL1R1
3
Show member pathways
Immune response MIF in innate immunity response61
9.4CD14, IL1R1
49.4CD14, IL1R1
59.4CD14, IL1R1
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4IL1R1, CD14
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.6CD14, IL1R1, IFNA2
8
Show member pathways
8.6IFNA2, IL1R1, CD14

Compounds for genes affiliated with Cardiogenic Shock

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate469.8CD14, IL1R1
2cuprophan469.6CD14, IL1R1
3ptca469.6NPPB, APOH
4polysulfone469.4CD14, IL1R1
5lipoteichoic acid469.4APOH, IL1R1, CD14
6endotoxin469.3IL1R1, CD14, APOH
7uric acid46 2510.3APOH, IL1R1, NPPB
8allopurinol46 52 1211.3IFNA2, NPPB
9p002469.2CD14, NPPB, APOH
10nitrate469.2IL1R1, CD14, NPPB
11p00001469.2NPPB, CD14
12pentoxifylline46 1210.2CD14, NPPB, IL1R1
13aspirin46 52 30 2512.2NPPB, IL1R1, APOH
14fibrinogen469.1CD14, IL1R1, APOH
15hydroxychloroquine46 1210.1IL1R1, APOH, IFNA2
16etanercept46 52 1211.1APOH, IL1R1, IFNA2
178-isoprostane469.1APOH, NPPB
18infliximab46 52 1211.1APOH, IFNA2, IL1R1
19rituximab46 52 1211.1IFNA2, IL1R1, APOH
20cellulose469.1IL1R1, CD14, IFNA2
21vitamin d469.0CD14, NPPB, IL1R1
22gold469.0APOH, IFNA2, IL1R1
23neopterin469.0IL1R1, IFNA2, CD14
24norepinephrine46 25 1210.9CD14, NPPB, IL1R1
25methionine468.9CD14, IL1R1, IFNA2
26cyclosporin a46 30 6210.8IL1R1, NPPB, CD14
27epinephrine46 25 1210.8NPPB, IL1R1, IFNA2
28p003468.8CD14, NPPB, IL1R1, APOH
29homocysteine46 259.8IL1R1, NPPB, CD14, APOH
30indomethacin46 30 62 1211.8NPPB, IL1R1, IFNA2
31lactate468.7APOH, IL1R1, NPPB, CD14
32creatinine468.7NPPB, CD14, IL1R1, APOH
33heparin46 30 25 1211.7NPPB, IL1R1, APOH, CD14
34arginine468.7CD14, NPPB, IL1R1, APOH
35phosphatidylinositol468.7CD14, IL1R1, APOH, NPPB
36histamine46 30 2510.6IFNA2, CD14, NPPB
37cyclophosphamide46 52 1210.5NPPB, IL1R1, IFNA2, APOH
38fatty acid468.5APOH, IL1R1, NPPB, IFNA2
39superoxide46 259.4APOH, IFNA2, NPPB, CD14
40progesterone46 30 62 25 1212.4IL1R1, APOH, IFNA2, NPPB
41zinc46 259.4IL1R1, NPPB, IFNA2, APOH
42oxygen46 259.4NPPB, IL1R1, APOH, IFNA2
43estrogen468.4NPPB, IL1R1, IFNA2, APOH
44cysteine468.3CD14, NPPB, IFNA2, IL1R1
45iron46 259.1IFNA2, NPPB, HFE2, IL1R1, APOH
46prednisolone46 30 1210.0CD14, IL1R1, IFNA2, NPPB, APOH
47steroid468.0IFNA2, IL1R1, NPPB, CD14, APOH
48vegf468.0NPPB, APOH, CD14, IL1R1, IFNA2
49glucose468.0IL1R1, CD14, APOH, IFNA2, NPPB
50lipid467.9APOH, IFNA2, CD14, IL1R1, NPPB

GO Terms for genes affiliated with Cardiogenic Shock

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Sources:
17Gene Ontology
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Cellular components related to Cardiogenic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312259.5CD14, HFE2
2cell surfaceGO:0099868.5APOH, IL1R1, HFE2, CD14
3extracellular regionGO:0055767.7CD14, NPPB, IL1R1, IFNA2
4extracellular spaceGO:0056157.6CD14, NPPB, HFE2, IFNA2, APOH

Biological processes related to Cardiogenic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of angiogenesisGO:0165259.4NPPB, APOH
2cell surface receptor signaling pathwayGO:0071667.7CD14, NPPB, IL1R1, IFNA2

Products for genes affiliated with Cardiogenic Shock

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiogenic Shock

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet