MCID: CRD137
MIFTS: 48

Cardiogenic Shock malady

Rare diseases, Cardiovascular diseases categories
Download this MalaCard

Summaries for Cardiogenic Shock

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Cardiogenic shock is based upon an inadequate circulation of blood due to primary failure of the... more...

MalaCards: Cardiogenic Shock, also known as shock, cardiogenic, is related to acute myocardial infarction and septic shock. An important gene associated with Cardiogenic Shock is HFE2 (hemochromatosis type 2 (juvenile)), and among its related pathways are Amoebiasis and TRAF Pathway. The drugs digitoxin and digoxin and the compounds gold sodium thiomalate and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and kidney.

Aliases & Classifications for Cardiogenic Shock

About this section
Sources:
49Orphanet, 62UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

49
cardiogenic shock:
Prevalence: 1-5/10000


Aliases & Descriptions:

cardiogenic shock 49
shock, cardiogenic 62


External Ids:

ICD10 via Orphanet26 R57.0
ICD1025 R57.0

Related Diseases for Cardiogenic Shock

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cardiogenic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.5NPPB, CD14
2septic shock30.6CD14, NPPB, IL1R1
3pulmonary embolism30.4NPPB, APOH
4lupus erythematosus30.4IFNA2, APOH
5atherosclerosis30.1CD14, IL1R1, APOH
6sepsis30.1IL1R1, NPPB, CD14
7diabetes mellitus30.1CD14, NPPB, IL1R1
8myocardial infarction11.2
9myocarditis10.7
10left ventricular outflow tract obstruction10.6
11pheochromocytoma10.5
12coronary artery disease10.5
13acute myocarditis10.5
14artery disease10.5
15inferior myocardial infarction10.4
16endocarditis10.4
17atrioventricular block10.3
18hypertrophic cardiomyopathy10.3
19hepatitis10.3
20hypertension10.3
21antiphospholipid syndrome10.3
22hemochromatosis10.3
23myxedema10.3
24myocardial stunning10.3
25churg-strauss syndrome10.3
26cerebritis10.3
27systemic lupus erythematosus10.3
28dilated cardiomyopathy10.3
29hypothyroidism10.3
30influenza10.3
31pneumonia10.3
32ventricular septal defect10.3
33catastrophic antiphospholipid syndrome10.3
34cardiac tamponade10.1
35hepatitis c10.1
36intrahepatic cholestasis10.1
37renovascular hypertension10.1
38panhypopituitarism10.1
39peripheral artery disease10.1
40peripartum cardiomyopathy10.1
41coronary thrombosis10.1
42anorexia nervosa10.1
43beriberi10.1
44propionic acidemia10.1
45constrictive pericarditis10.1
46pulmonary edema10.1
47hypophosphatemia10.1
48congenital hypothyroidism10.1
49anterolateral myocardial infarction10.1
50phaeochromocytoma10.1

Graphical network of the top 20 diseases related to Cardiogenic Shock:



Diseases related to cardiogenic shock

Symptoms for Cardiogenic Shock

About this section

Drugs & Therapeutics for Cardiogenic Shock

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Cardiogenic Shock

Search NIH Clinical Center for Cardiogenic Shock

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cardiogenic Shock

About this section

Anatomical Context for Cardiogenic Shock

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cardiogenic Shock:

33
Heart, Liver, Kidney, Monocytes, Lung, Breast, Prostate, Tongue, Pituitary

Animal Models for Cardiogenic Shock or affiliated genes

About this section

Publications for Cardiogenic Shock

About this section
Sources:
52PubMed
See all sources

Articles related to Cardiogenic Shock:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Wretched excess: stool-softener abuse and cardiogenic shock. (23968901)
2013
2
Levosimendan for the treatment of subarachnoid hemorrhage-related cardiogenic shock. (23673402)
2013
3
A new approach for early onset cardiogenic shock in acute colchicine overdose: place of early extracorporeal life support (ECLS)? (23612758)
2013
4
BET 3: evaluation of intra-aortic balloon support in cardiogenic shock. (24232009)
2013
5
Cardiogenic shock. (24188221)
2013
6
Intraaortic balloon support for cardiogenic shock. (23281984)
2013
7
Post myocardial infarction cardiogenic shock: a review of current therapies. (21747126)
2013
8
Cardiovascular outcomes using intra-aortic balloon pump in high-risk acute myocardial infarction with or without cardiogenic shock: a meta-analysis. (21335478)
2012
9
Balloon pump support for cardiogenic shock after AMI. (23099571)
2012
10
Intra-aortic balloon support for MI and cardiogenic shock--time to change the guidelines? (22965109)
2012
11
Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock. (22386227)
2012
12
What is the evidence for IABP in STEMI with and without cardiogenic shock? (22569335)
2012
13
Repairing a "broken heart" with hormone replacement therapy: case report of cardiogenic shock due to undiagnosed pituitary insufficiency. (22138080)
2012
14
Intra-aortic balloon counterpulsation in the treatment of infarction-related cardiogenic shock--review of the current evidence. (22607158)
2012
15
Cardiogenic shock and awe. (22378244)
2012
16
Role of receptor for advanced glycation end products in cardiogenic shock. (22430238)
2012
17
Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial. (22709745)
2012
18
Emergency surgery for native mitral valve endocarditis: the impact of septic and cardiogenic shock. (22342063)
2012
19
Aorto-right atrial fistula secondary to infective endocarditis presenting with cardiogenic shock. (21045716)
2012
20
Successful use of a percutaneous miniaturized extracorporeal life support system as a bridge and assistance to left ventricular assist device implantation in a patient with severe refractory cardiogenic shock. (21859786)
2012
21
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
22
Cardiogenic shock in an elderly man caused by left main coronary artery occlusion with spontaneous dissection of right coronary artery. (21152670)
2011
23
Impella assisted transradial coronary intervention in patients with acute coronary syndromes and cardiogenic shock: case series. (21523889)
2011
24
The ability to achieve complete revascularization is associated with improved in-hospital survival in cardiogenic shock due to myocardial infarction: Manitoba cardiogenic SHOCK Registry investigators. (21547996)
2011
25
Defining refractory myocardial infarction-associated cardiogenic shock: an ongoing elusive challenge. (21248538)
2011
26
Evaluation and management of shock States: hypovolemic, distributive, and cardiogenic shock. (21507874)
2011
27
Hypothermia in cardiogenic shock reduces systemic t-PA release. (21190125)
2011
28
Cardiogenic shock due to dynamic left ventricular outflow tract obstruction in acute myocardial infarction. (21452037)
2011
29
Posterior ventricular septal defect in presence of cardiogenic shock: early implantation of the impella recover LP 5.0 as a bridge to surgery. (21423467)
2011
30
Mechanical versus pharmacologic support for cardiogenic shock. (20049971)
2010
31
Immediate cardiac arrest and subsequent development of cardiogenic shock caused by lightning strike. (20065746)
2010
32
Early extracorporeal membrane oxygenator-assisted primary percutaneous coronary intervention improved 30-day clinical outcomes in patients with ST-segment elevation myocardial infarction complicated with profound cardiogenic shock. (20543669)
2010
33
Intraoperative pulseless electrical activity and acute cardiogenic shock after administration of phenylephrine, epinephrine, and ketamine. (21603379)
2010
34
Acute kidney injury in ST-segment elevation acute myocardial infarction complicated by cardiogenic shock at admission. (19789449)
2010
35
Case series: CT scan in cardiac arrest and imminent cardiogenic shock. (20607032)
2010
36
Reversible cardiogenic shock in hypertrophic cardiomyopathy after alcohol septal ablation. (21074128)
2010
37
Combined use of Impella device and intra-aortic balloon pump to improve survival in a patient in profound cardiogenic shock post cardiac arrest. (19521993)
2009
38
Catastrophic antiphospholipid syndrome complicated by cardiogenic shock - a case report]. (19650000)
2009
39
Percutaneous left ventricular assist devices during cardiogenic shock and high-risk percutaneous coronary interventions. (19709497)
2009
40
The use of extracorporeal membrane oxygenation in patients with therapy refractory cardiogenic shock as a bridge to implantable left ventricular assist device and perioperative right heart support. (19894089)
2009
41
Clinical significance of post-procedural TIMI flow in patients with cardiogenic shock undergoing primary percutaneous coronary intervention. (19463399)
2009
42
Coronary artery bypass graft surgery provides better survival in patients with acute coronary syndrome or ST-segment elevation myocardial infarction experiencing cardiogenic shock after percutaneous coronary intervention: a propensity score analysis. (19660378)
2009
43
Contemporary management of cardiogenic shock: age is opportunity. (19463418)
2009
44
Cardiogenic shock without flow-limiting angiographic coronary artery disease: (from the Should We Emergently Revascularize Occluded Coronary Arteries for Cardiogenic Shock Trial and Registry). (19576316)
2009
45
Usefulness of intra-aortic balloon pump counterpulsation in patients with cardiogenic shock from acute myocardial infarction. (19616662)
2009
46
Images in cardiology: Acute adrenal insufficiency complicated by cardiogenic shock. (15772180)
2005
47
Comparative study of artificial circulation for the liver after cardiogenic shock: pulsatile or nonpulsatile?]. (9884562)
1998
48
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
49
Role of right ventricular infarction in cardiogenic shock associated with inferior myocardial infarction. (534590)
1979
50
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969

Variations for Cardiogenic Shock

About this section

Expression for genes affiliated with Cardiogenic Shock

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cardiogenic Shock

Search GEO for disease gene expression data for Cardiogenic Shock.

Pathways for genes affiliated with Cardiogenic Shock

About this section
Sources:
50PathCards, 30KEGG, 53QIAGEN, 60Thomson Reuters, 54R&D Systems
See all sources

Pathways related to Cardiogenic Shock according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD14, IL1R1
2
Show member pathways
9.4CD14, IL1R1
3
Show member pathways
Immune response MIF in innate immunity response60
9.4CD14, IL1R1
49.4CD14, IL1R1
59.4CD14, IL1R1
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4IL1R1, CD14
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.6CD14, IL1R1, IFNA2
8
Show member pathways
8.6IFNA2, IL1R1, CD14

Compounds for genes affiliated with Cardiogenic Shock

About this section
Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Cardiogenic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate459.8CD14, IL1R1
2cuprophan459.6CD14, IL1R1
3ptca459.6NPPB, APOH
4polysulfone459.4CD14, IL1R1
5lipoteichoic acid459.4APOH, IL1R1, CD14
6endotoxin459.3IL1R1, CD14, APOH
7uric acid45 2410.3APOH, IL1R1, NPPB
8allopurinol45 51 1111.3IFNA2, NPPB
9p002459.2CD14, NPPB, APOH
10nitrate459.2IL1R1, CD14, NPPB
11p00001459.2NPPB, CD14
12pentoxifylline45 1110.2CD14, NPPB, IL1R1
13aspirin45 51 29 2412.2NPPB, IL1R1, APOH
14fibrinogen459.1CD14, IL1R1, APOH
15hydroxychloroquine45 1110.1IL1R1, APOH, IFNA2
16etanercept45 51 1111.1APOH, IL1R1, IFNA2
178-isoprostane459.1APOH, NPPB
18infliximab45 51 1111.1APOH, IFNA2, IL1R1
19rituximab45 51 1111.1IFNA2, IL1R1, APOH
20cellulose459.1IL1R1, CD14, IFNA2
21vitamin d459.0CD14, NPPB, IL1R1
22gold459.0APOH, IFNA2, IL1R1
23neopterin459.0IL1R1, IFNA2, CD14
24norepinephrine45 24 1110.9CD14, NPPB, IL1R1
25methionine458.9CD14, IL1R1, IFNA2
26cyclosporin a45 29 6110.8IL1R1, NPPB, CD14
27epinephrine45 24 1110.8NPPB, IL1R1, IFNA2
28p003458.8CD14, NPPB, IL1R1, APOH
29homocysteine45 249.8IL1R1, NPPB, CD14, APOH
30indomethacin45 29 61 1111.8NPPB, IL1R1, IFNA2
31lactate458.7APOH, IL1R1, NPPB, CD14
32creatinine458.7NPPB, CD14, IL1R1, APOH
33heparin45 29 24 1111.7NPPB, IL1R1, APOH, CD14
34arginine458.7CD14, NPPB, IL1R1, APOH
35phosphatidylinositol458.7CD14, IL1R1, APOH, NPPB
36histamine45 29 2410.6IFNA2, CD14, NPPB
37cyclophosphamide45 51 1110.5NPPB, IL1R1, IFNA2, APOH
38fatty acid458.5APOH, IL1R1, NPPB, IFNA2
39superoxide45 249.4APOH, IFNA2, NPPB, CD14
40progesterone45 29 61 24 1112.4IL1R1, APOH, IFNA2, NPPB
41zinc45 249.4IL1R1, NPPB, IFNA2, APOH
42oxygen45 249.4NPPB, IL1R1, APOH, IFNA2
43estrogen458.4NPPB, IL1R1, IFNA2, APOH
44cysteine458.3CD14, NPPB, IFNA2, IL1R1
45iron45 249.1IFNA2, NPPB, HFE2, IL1R1, APOH
46prednisolone45 29 1110.0CD14, IL1R1, IFNA2, NPPB, APOH
47steroid458.0IFNA2, IL1R1, NPPB, CD14, APOH
48vegf458.0NPPB, APOH, CD14, IL1R1, IFNA2
49glucose458.0IL1R1, CD14, APOH, IFNA2, NPPB
50lipid457.9APOH, IFNA2, CD14, IL1R1, NPPB

GO Terms for genes affiliated with Cardiogenic Shock

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cardiogenic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312259.5CD14, HFE2
2cell surfaceGO:0099868.5APOH, IL1R1, HFE2, CD14
3extracellular regionGO:0055767.7CD14, NPPB, IL1R1, IFNA2
4extracellular spaceGO:0056157.6CD14, NPPB, HFE2, IFNA2, APOH

Biological processes related to Cardiogenic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of angiogenesisGO:0165259.4NPPB, APOH
2cell surface receptor signaling pathwayGO:0071667.7CD14, NPPB, IL1R1, IFNA2

Products for genes affiliated with Cardiogenic Shock

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cardiogenic Shock

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet