Cardiomyopathy malady

MedlinePlus: Cardiomyopathy refers to diseases of the heart muscle. these diseases enlarge your heart muscle or make it thicker and more rigid than normal. in rare cases, scar tissue replaces the muscle tissue. some people live long, healthy lives with cardiomyopathy. some people don't even realize they have it. in others, however, it can make the heart less able to pump blood through the body. this can cause serious complications, including heart failure abnormal heart rhythms fluid buildup in your lungs or legs endocarditis, an inflammation of the heart lining heart attacks, high blood pressure or infections can all cause cardiomyopathy. some types of cardiomyopathy run in families. in many people, however, the cause is unknown. treatment might involve medicines, surgery, other medical procedures and lifestyle changes. nih: national heart, lung, and blood institute²³

MalaCards: Cardiomyopathy, also known as cardiomyopathies, is related to dmd-associated dilated cardiomyopathy and hypertrophic cardiomyopathy. An important gene associated with Cardiomyopathy is TNNT2 (troponin T type 2 (cardiac)), and among its related pathways are Focal adhesion and Parkinsons disease. The compounds adp and carnitine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are endocrine/exocrine gland and embryogenesis.

Wikipedia: Cardiomyopathy (literally \"heart muscle disease\") is the measurable deterioration of the function of...⁴⁴ more...

cardiomyopathy 7 17 32 23 cardiomyopathies 43

Diseases related to cardiomyopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1081)

id	Related Disease	Score	Top Affiliating Genes
1	dmd-associated dilated cardiomyopathy	93.7	PIK3C2A, PDE3A, REN, SGCA, SGCB, SGCD
2	hypertrophic cardiomyopathy	74.8	PIK3C2A, COA5, REN, RETN, SGCA, SGCB
3	carcinoma	73.3	PIK3C2A, PIK3CG, PIM1, NCAM1, PDCD1, PDE3A
4	neuronitis	67.8	PIK3C2A, PIK3CG, PIM1, NCAM1, PDE3A, REN
5	hypertension	62.5	PIK3C2A, PIK3CG, PIM1, NCAM1, PDE3A, REN
6	leukemia	59.9	PIK3C2A, PIK3CG, PIM1, NCAM1, PDCD1, REN
7	myopathy	59.3	PIK3C2A, COA5, NCAM1, SGCA, SGCB, VDAC1
8	myocardial infarction	56.8	PIK3C2A, PIK3CG, PDCD1, REN, RETN, SGCB
9	fibrosis	55.5	PIK3CG, PDE3A, REN, RETN, CNR1, KITLG
10	ischemia	54.4	PIK3C2A, PIK3CG, NCAM1, REN, RETN, SGCB
11	diabetes mellitus	54.2	PIK3C2A, PIK3CG, PDCD1, REN, RETN, SGCB
12	colorectal cancer	52.4	PIK3CG, NCAM1, RETN, CNR1, KITLG, VWF
13	obesity	49.5	PIK3C2A, PIK3CG, REN, RETN, CNR1, VWF
14	schizophrenia	48.5	PIK3CG, NCAM1, CNR1, PCNA, GCH1, SERPINA1
15	neuropathy	47.9	PIK3C2A, NCAM1, REN, RETN, SGCA, CNR1
16	arrhythmogenic right ventricular dysplasia/cardiomyopathy multi-gene panels	47.4	PIK3C2A, REN, SGCD, RBM20, SERPINE1, LPL
17	familial hypertrophic cardiomyopathy	47.2	VCL, MYBPC3, MYLK2, MYOZ2, MYBPC1, MYBPC2
18	lupus erythematosus	46.9	PIK3C2A, PIK3CG, PDCD1, RETN, VWF, PCNA
19	insulin resistance	46.8	PIK3CG, REN, RETN, CNR1, VWF, PCK2
20	myocarditis	46.1	PIK3C2A, NCAM1, SGCA, SGCB, SGCD, SELP
21	atrial fibrillation	45.3	PIK3C2A, REN, RETN, VWF, PCNA, SELP
22	acute myocardial infarction	44.3	PIK3C2A, PIK3CG, REN, RETN, KITLG, VWF
23	anemia	42.5	PIM1, NCAM1, PDCD1, REN, SGCB, KITLG
24	aldosteronism	41.9	PIK3CG, REN, RETN, GCH1, SERPINE1, VEGFA
25	coronary heart disease	41.7	PIK3C2A, RETN, VWF, SELP, SERPINC1, SERPINA1
26	ataxia	40.7	PIK3CG, VWF, PCNA, GCA, SERPINE1, USP7
27	chagas disease	39.3	PIK3CG, SERPINC1, SERPINE1, MYD88, BDKRB2, CHRM2
28	muscular dystrophy	39.1	PIK3C2A, NCAM1, SGCA, SGCB, SGCD, LMNA
29	familial dilated cardiomyopathy	38.9	RBM20, LMNA, MYOZ2, MYOZ1, CMD1B, CMD1D
30	congestive heart failure	38.7	PIK3C2A, PIK3CG, REN, GCA, UTS2, CHRM2
31	ischemic heart disease	38.0	PIK3C2A, RETN, SELP, SERPINE1, LPL, VCL
32	type 2 diabetes mellitus	37.8	RETN, CNR1, VWF, PCK2, SELP, SERPINE1
33	cataract	37.7	SGCB, PCNA, VEGFA, LMNA, MYOT, BMP6
34	arrhythmogenic right ventricular dysplasia	37.2	MYOZ2, SCN5A, JUP, ARVD1, ARVD3, ARVD4
35	graves' disease	36.9	PDCD1, RETN, KITLG, VWF, BMP6, SDHA
36	prostatitis	36.8	PIK3C2A, PIK3CG, PIM1, NCAM1, PDCD1, RETN
37	hearing loss	36.4	SGCA, SERPINC1, SERPINE1, MYO6, BAX, MT-ND5
38	familial restrictive cardiomyopathy	36.4	RCM2, MYBPC3, MYPN, MAPK8, TPM1, TNNC1
39	sepsis	36.2	RETN, SELP, SERPINC1, SERPINE1, LPL, VDAC1
40	hypotonia	36.2	COA5, PCK2, GCH1, NAGA, LMNA, SCO1
41	sudden cardiac death multi-gene panels	36.2	LMNA, MYBPC3, KCNH2, SCN5A, MMP3, FKBP1B
42	hyperthyroidism	36.1	PIK3C2A, REN, RETN, KITLG, VWF, SELP
43	lipodystrophy	35.9	RETN, SERPINE1, LPL, LMNA, LMNB1, LMNB2
44	duodenitis	35.7	PIK3CG, KITLG, PCNA, BRAF, LPL, CMA1
45	hypoglycemia	35.6	PIK3CG, PCK2, PCNA, VEGFA, LPL, CKB
46	amyloidosis	35.5	VWF, SERPINC1, SERPINA3, LPL, CLU, B2M
47	glycogen storage disease	35.5	VWF, LPL, BMP6, CKM, CHKB, LAMP2
48	systemic lupus erythematosus	35.2	PDCD1, VWF, LMNB1, CLU, CIITA, LCK
49	pancreatitis	35.1	PIK3C2A, PIK3CG, PIM1, NCAM1, REN, RETN
50	myotonic dystrophy	35.0	PIK3C2A, REN, SGCA, LMNA, MYOM1, MYOZ2

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to cardiomyopathy:

²²

MGI Mouse Phenotypes related to cardiomyopathy:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	INF	PAFAH1B1, PAFAH1B2, BDKRB2, UBR1, LAMA2, XDH
2	embryogenesis phenotype	MP:0005380	INF	SERPINC1, , VCL, LMNB1, LMNB2, MYOCD
3	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, PDCD1, REN, SGCA, SGCB, SGCD
4	vision/eye phenotype	MP:0005391	INF	NCAM1, PDCD1, KITLG, SELP, SERPINC1,
5	growth/size phenotype	MP:0005378	INF	PIK3C2A, PIK3CG, PIM1, REN, SGCB, CNR1
6	reproductive system phenotype	MP:0005389	INF	PDE3A, REN, NAB2, VEGFA, LMNA, MYO6
7	no phenotypic analysis	MP:0003012	INF	CNR1, PCNA, VEGFA, MYD88, MYOT, PARP1
8	respiratory system phenotype	MP:0005388	INF	SELP, NAB2, LPL, LMNB2, UTRN, CHRM2
9	tumorigenesis	MP:0002006	INF	KITLG, SERPINE1, , MYD88, BIN1, B2M
10	integument phenotype	MP:0010771	INF	PIK3CG, CNR1, KITLG, RCE1, SELP, NAB2
11	other phenotype	MP:0005395	12.6	SGCD, CNR1, CLU, KDR, LAMA2, LAMA4
12	renal/urinary system phenotype	MP:0005367	INF	PDCD1, REN, SELP, , LMNA, MYD88
13	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, RETN, CNR1, SERPINE1, , LPL
14	cellular phenotype	MP:0005384	INF	PIK3CG, PIM1, NCAM1, PDCD1, CNR1, KITLG
15	mortality/aging	MP:0010768	INF	PIK3C2A, NCAM1, PDCD1, REN, SGCD, CNR1
16	muscle phenotype	MP:0005369	INF	PIK3CG, PDCD1, REN, SGCA, SGCB, SGCD
17	liver/biliary system phenotype	MP:0005370	INF	RETN, RCE1, SERPINC1, VEGFA, LPL, UTRN
18	hematopoietic system phenotype	MP:0005397	INF	PIM1, PDCD1, PCNA, , MYD88, BIRC6
19	behavior/neurological phenotype	MP:0005386	INF	NCAM1, REN, CNR1, RCE1, SELP, NAB2
20	digestive/alimentary phenotype	MP:0005381	INF	KITLG, VWF, , VEGFA, VCL, LMNA
21	nervous system phenotype	MP:0003631	INF	PDCD1, REN, CNR1, KITLG, VWF, SELP
22	immune system phenotype	MP:0005387	INF	REN, SGCA, SGCB, VWF, SELP,
23	normal phenotype	MP:0002873	INF	PDE3A, REN, NAB2, , VEGFA, LMNA
24	craniofacial phenotype	MP:0005382	INF	KITLG, LMNB1, LMNB2, MYO6, KCNH2, LAMA2
25	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PIK3CG, REN, RETN, SGCA, SGCD
26	limbs/digits/tail phenotype	MP:0005371	INF	KITLG, VEGFA, VCL, LMNA, UTRN, CHKB
27	skeleton phenotype	MP:0005390	INF	PIK3CG, CNR1, KITLG, NAB2, , VEGFA
28	hearing/vestibular/ear phenotype	MP:0005377	INF	KITLG, LMNA, MYD88, MYO6, PARP1, BAX

Articles related to cardiomyopathy:

(show top 50)    (show all 1631)

id	Title	Authors	Year	Affiliating Genes
1	EH-myomesin splice isoform is a novel marker for dila ted cardiomyopathy. (21069531)	Schoenauer R.... Agarkova I.	2011	MYOM1
2	Furthering the link between the sarcomere and primary cardiomyopathies: restrictive cardiomyopathy associated with multiple mutation s in genes previously associated with hypertrophic or dilated cardiomyopathy. (21823217)	Caleshu C.... Rame J.E.	2011	TPM1, MYL3, MYL2
3	Desmin myopathy with severe cardiomyopathy in a Urugu ayan family due to a codon deletion in a new location within the desmin 1A rod domain. (20133133)	Vernengo L.... Rodriguez M.M.	2010	DES
4	Resistin gene promoter region polymorphism and the ri sk of hypertrophic cardiomyopathy in patients. (20171599)	Hussain S.... Javed Q.	2010	RETN
5	The R820W mutation in the MYBPC3 gene, associated wit h hypertrophic cardiomyopathy in cats, causes hypertrophic cardiomyopathy and l eft ventricular non-compaction in humans. (20542340)	Ripoll Vera T.... Torres MarquAcs J.	2010	MYBPC3
6	Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. (19649297)	Karakikes I.... Lebeche D.	2009	ATP2A2
7	Analysis of 8 sarcomeric candidate genes for feline h ypertrophic cardiomyopathy mutations in cats with hypertrophic cardiomyopathy. (19566849)	Meurs K.M.... Kittleson M.	2009	MYBPC3
8	Clinical features, survival experience, and profile o f plakophylin-2 gene mutations in participants of the arrhythmogenic right vent ricular cardiomyopathy registry of South Africa. (19880068)	Watkins D.A.... Mayosi B.M.	2009	PKP2
9	Familial amyloid cardiomyopathy due to TTR mutations: an underdiagnosed cause of restrictive cardiomyopathy [corrected (19477408)	Ruberg F.L.... Maurer M.S.	2009	TTR
10	Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy. (19015585)	Arimura T.... Kimura A.	2009	FKTN
11	HLA-DQB1* polymorphism and associations with dilated cardiomyopathy, inflammatory dilated cardiomyopathy and myocarditis. (19127454)	Portig I.... Maisch B.	2009	HLA-DQB1
12	ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy. (18165925)	Rai T.S.... Khullar M.	2008	ACE
13	Six-minute walk test in Chagas cardiomyopathy. (17399822)	Sousa L.... Ribeiro A.L.	2008	NPPB
14	Dystrophin: from non-ischemic cardiomyopathy to ischemic cardiomyopathy. (18562127)	Zheng Q.S.... Li H.	2008	DMD
15	Intrauterine cardiomyopathy and cardiac mitochondrial proliferation in mitochondrial trifunctional protein (TFP) deficiency. (18485779)	Spiekerkoetter U.... Korenke C.	2008	HADHA
16	Worse prognosis with gene mutations of beta-myosin heavy chain than myosin-binding protein C in Chinese patients with hypertrophic cardiomyopathy. (18383048)	Wang S.... Hui R.	2008	MYH7
17	High yield of LMNA mutations in patients with dilated cardiomyopathy and/or conduction disease referred to cardiogenetics outpatient clinics. (18035086)	van Tintelen J.P.... Van Den Berg M.P.	2007	LMNA
18	Antibodies against the beta1-adrenergic receptor induce progressive development of cardiomyopathy. (17362986)	Buvall L.... Fu M.	2007	ADRB1
19	Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects. (17611253)	Monserrat L.... Castro-Beiras A.	2007	ACTC1
20	Cardiac beta-myosin heavy chain defects in two families with non-compaction cardiomyopathy: linking non-compaction to hypertrophic, restrictive, and dilated cardiomyopathies. (17947214)	Hoedemaekers Y.M.... Dooijes D.	2007	MYH7
21	Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy. (16415378)	Syrris P.... McKenna W.J.	2006	PKP2
22	TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients. (16427798)	Drigo S.A.... Goldberg A.C.	2006	TNF
23	Decreased serum lipoprotein levels as a guide for clinical severity in patients with idiopathic dilated cardiomyopathy. (15942148)	Sezgin N.... Temel I.	2005	IL6
24	Hyperthrophic cardiomyopathy and the PTPN11 gene. (15937948)	Sarkozy A.... Tartaglia M.	2005	PTPN11
25	C-reactive protein co-expresses with tumor necrosis factor-alpha in the myocardium in human dilated cardiomyopathy. (16087131)	Satoh M.... Hiramori K.	2005	AGTR1
26	Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. (16199542)	Ingles J.... Semsarian C.	2005	MYH7
27	Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations. (14991917)	Digilio M.C.... Dallapiccola B.	2004	PTPN11
28	Peroxisome proliferator activator receptors (PPAR), insulin resistance, and cardiomyopathy: friends or foes for the diabetic patient with heart failure? (15078585)	Nikolaidis L.A.... Levine T.B.	2004	PPARA
29	Analytical performance and diagnostic accuracy of a fully-automated electrochemiluminescent assay for the N-terminal fragment of the pro-peptide of brain natriuretic peptide in patients with cardiomyopathy: comparison with immunoradiometric assay methods for brain natriuretic peptide and atrial natriuretic peptide. (15061378)	Prontera C.... Clerico A.	2004	NPPB, NPPA
30	Comparison of circulating levels of interleukin-6 and tumor necrosis factor-alpha in hypertrophic cardiomyopathy and in idiopathic dilated cardiomyopathy. (15246916)	HAPgye M.... BuzA!s K.	2004	TNF, IL6
31	Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. (15582318)	Hayashi T.... Kimura A.	2004	MYBPC3, TCAP, CSRP3
32	Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization. (14654368)	Lu Q.W.... Ohtsuki I.	2003	TNNT2
33	Left ventricular systolic dysfunction and nonischemic cardiomyopathy. (12669941)	Tarolli K.A.	2003	ACE
34	Hypertrophic cardiomyopathy: two homozygous cases with 'typical' hypertrophic cardiomyopathy and three new mutations in cases with progression to dilated cardiomyopathy. (12951062)	Nanni L.... Lanfranchi G.	2003	MYH7
35	Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. (12186860)	Robinson P.... Redwood C.	2002	TNNT2
36	The Val606Met mutation in the cardiac beta-myosin heavy chain gene in patients with familial hypertrophic cardiomyopathy is associated with a high risk of sudden death at young age. (11377367)	Havndrup O.... Christiansen M.	2001	MYH7
37	Mitochondrial respiratory chain activity in idiopathic dilated cardiomyopathy. (10746819)	Quigley A.F.... Byrne E.	2000	COX5A
38	Upregulation of adhesion molecules and class I HLA in the myocardium of chronic chagasic cardiomyopathy and heart allograft rejection, but not in dilated cardiomyopathy. (10867361)	Benvenuti L.A.... Reis M.M.	2000	ITGAL
39	Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. (10026353)	Mundhenke M.... Strauer B.E.	1999	EDN1
40	Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy. (10330430)	Mogensen J.... Boerglum A.D.	1999	ACTC1
41	Abnormal skeletal muscle bioenergetics in familial hypertrophic cardiomyopathy. (9326994)	Thompson C.H.... Radda G.K.	1997	MYH7
42	Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy. (9344764)	Li Y.Y.... Hengstenberg C.	1997	MT-CO1, MT-ND5
43	Apoptosis in the process from viral myocarditis to dilated cardiomyopathy (8741699)	Satoh M.... Satodate R.	1996	FAS
44	Five candidate genes for hamster cardiomyopathy did not map to the cardiomyopathy locus by FISH analysis. (8946168)	Takada S.... Matsuda Y.	1996	SGCA
45	Norepinephrine and atrial natriuretic peptide responses to exercise testing in rehabilitated and nonrehabilitated men with ischemic cardiomyopathy after healing of anterior wall acute myocardial infarction. (7747694)	Shemesh J.... Motro M.	1995	NPPA
46	Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease. (7488459)	de Belder A.J.... Martin J.F.	1995	NOS2
47	Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. (8205619)	Thierfelder L.... Seidman C.E.	1994	TPM1, TNNT2, TNNC1
48	The cardiomyopathy of Duchenne's muscular dystrophy and the function of dystrophin. (8502196)	Cziner D.G.... Levin R.I.	1993	DMD
49	Pathophysiological and biochemical characterisation o f an avian model of dilated cardiomyopathy: comparison to findings in human dil ated cardiomyopathy. (8313431)	Hajjar R.J.... Gwathmey J.K.	1993	DNAH8
50	Expression and distribution of atrial natriuretic peptide in human hypertrophic ventricle of hypertensive hearts and hearts with hypertrophic cardiomyopathy. (1824622)	Takemura G.... Tanaka M.	1991	NPPA

Genes related to cardiomyopathy according to GeneCards:

(show top 50)    (show all 628)

id	Symbol	Description	Score	GeneCards Section Context
1	TNNT2	troponin T type 2 (cardiac)	11.1	Summaries, Publications, Aliases & Descriptions
2	TTN	titin	11.1	Summaries, Orthologs, Publications, Aliases & Descriptions
3	TPM1	tropomyosin 1 (alpha)	11.1	Summaries, Publications, Aliases & Descriptions, Orthologs
4	MYH6	myosin, heavy chain 6, cardiac muscle, alpha	11.1	Pathways & Interactions, Summaries, Aliases & Descriptions, Publications
5	LMNA	lamin A/C	11.1	Summaries, Aliases & Descriptions, Publications
6	TAZ	tafazzin	11.1	Summaries, Publications, Aliases & Descriptions
7	TNNI3	troponin I type 3 (cardiac)	11.1	Publications, Summaries
8	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.1	Publications, Summaries
9	ACTC1	actin, alpha, cardiac muscle 1	11.1	Summaries, Publications
10	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	11.1	Summaries, Publications
11	VCL	vinculin	11.1	Publications, Summaries
12	MYBPC3	myosin binding protein C, cardiac	11.1	Publications, Summaries
13	TNNC1	troponin C type 1 (slow)	11.0	Summaries, Publications
14	MYL2	myosin, light chain 2, regulatory, cardiac, slow	11.0	Summaries, Publications
15	PLN	phospholamban	11.0	Summaries, Publications
16	MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	11.0	Summaries, Publications
17	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	11.0	Summaries, Publications
18	CMD2A	cardiomyopathy, dilated 2A (autosomal recessive)	11.0	Aliases & Descriptions
19	MYOZ2	myozenin 2	11.0	Summaries, Publications
20	DSP	desmoplakin	11.0	Publications, Summaries
21	LDB3	LIM domain binding 3	11.0	Publications, Summaries
22	TTR	transthyretin	11.0	Publications, Summaries
23	CMD1D	cardiomyopathy, dilated 1D (autosomal dominant)	11.0	Aliases & Descriptions, Publications
24	NEXN	nexilin (F actin binding protein)	11.0	Publications, Summaries
25	MYBPC2	myosin binding protein C, fast type	11.0	Summaries, Publications
26	FKTN	fukutin	11.0	Summaries, Publications
27	RBM20	RNA binding motif protein 20	11.0	Publications, Summaries
28	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	11.0	Summaries, Publications
29	TMPO	thymopoietin	11.0	Summaries, Publications
30	CMD1F	cardiomyopathy, dilated 1F (autosomal dominant)	11.0	Aliases & Descriptions, Publications
31	CMD1B	cardiomyopathy, dilated 1B (autosomal dominant)	11.0	Aliases & Descriptions, Publications
32	RCM2	cardiomyopathy, familial restrictive, 2	11.0	Aliases & Descriptions, Publications
33	CMD1Q	cardiomyopathy, dilated 1Q (autosomal dominant)	11.0	Publications, Aliases & Descriptions
34	CMD1H	cardiomyopathy, dilated 1H (autosomal dominant)	11.0	Aliases & Descriptions, Publications
35	CMD1K	cardiomyopathy, dilated 1K (autosomal dominant)	11.0	Aliases & Descriptions, Publications
36	CALR3	calreticulin 3	11.0	Publications, Summaries
37	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Summaries, Publications
38	HFE2	hemochromatosis type 2 (juvenile)	11.0	Summaries, Publications
39	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Publications, Summaries
40	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	11.0	Publications, Summaries
41	EYA4	eyes absent homolog 4 (Drosophila)	11.0	Summaries, Publications
42	XIRP1	xin actin-binding repeat containing 1	11.0	Aliases & Descriptions, Publications, Orthologs
43	CMYA5	cardiomyopathy associated 5	11.0	Publications, Transcripts, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
44	TMEM43	transmembrane protein 43	11.0	Publications, Summaries
45	PDE4DIP	phosphodiesterase 4D interacting protein	11.0	Aliases & Descriptions
46	XIRP2	xin actin-binding repeat containing 2	11.0	Publications, Aliases & Descriptions
47	DNAJC19	DnaJ (Hsp40) homolog, subfamily C, member 19	11.0	Summaries
48	FOXD4	forkhead box D4	11.0	Summaries, Publications
49	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	11.0	Summaries, Publications
50	HAMP	hepcidin antimicrobial peptide	11.0	Summaries, Publications

Pathways related to cardiomyopathy according to GeneDecks:

(show top 50)    (show all 228)

id	Pathway	Score	Top Affiliating Genes
1	Focal adhesion20	INF	PIK3CG, VWF, , VEGFB, VCL,
2	Parkinsons disease20	INF	VDAC1, SDHA, MT-ND5, , MT-CO1,
3	Hypertrophic cardiomyopathy (HCM)20	15.7	SGCA, SGCB, SGCD, LMNA, MYBPC3, LAMA2
4	Dilated cardiomyopathy20	15.6	SGCA, SGCB, SGCD, LMNA, MYBPC3, LAMA2
5	ILK Signaling36	14.2	KITLG, VEGFB, MYO6, MYH7B, UTS2, LIMS1
6	Antioxidant Action of Vitamin-C36	14.1	KITLG, VEGFB, MYO6, MYH7B, BMP6, UTS2
7	Epithelial Adherens Junctions36	13.9	KITLG, VEGFB, VCL, MYO6, MYH7B, BMP6
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	13.9	SGCA, SGCB, SGCD, LMNA, LAMA2, ATP2A2
9	PAK Pathway36	13.7	KITLG, VEGFB, MYO6, MYH7B, BMP6, UTS2
10	Tec Kinases Signaling36	13.5	KITLG, VEGFB, MYD88, BMP6, UTS2, BAX
11	Rho Family GTPases36	13.4	KITLG, VEGFB, BMP6, RAF1, UTS2, KDR
12	Striated Muscle Contraction38	13.3	MYBPC3, MYBPC1, MYBPC2, TPM1, TPM2, TPM3
13	Antiarrhythmic Pathway, Pharmacodynamics34	13.2	LMNA, KCNH2, KCNIP2, SCN5A, CHRM2, ATP2A2
14	Akt Signaling36	13.1	PIK3CG, VEGFB, RAF1, UTS2, ITGAL, GYS1
15	Viral myocarditis20	12.8	SGCA, SGCB, SGCD, MYH7B, LAMA2, FYN
16	Intracellular Calcium Signaling36	12.8	KITLG, VEGFB, BMP6, UTS2, KDR, P2RX1
17	JAK-STAT Pathway36	12.7	KITLG, VEGFB, BMP6, RAF1, UTS2, KDR
18	NF-KappaB (p50-p65) Pathway36	12.6	KITLG, VEGFB, MYD88, BMP6, UTS2, KDR
19	eNOS Signaling36	12.6	KITLG, BMP6, UTS2, BDKRB1, BDKRB2, FGF1
20	ERK5 Signaling36	12.5	KITLG, VEGFB, BMP6, UTS2, KDR, FOS
21	IP3 Pathway36	12.5	KITLG, VEGFB, BMP6, UTS2, KDR, FYN
22	Cellular Apoptosis Pathway36	12.2	KITLG, VEGFB, VDAC1, BMP6, UTS2, KDR
23	Renin-Angiotensin Pathway36	12.2	REN, KITLG, VEGFB, BMP6, RAF1, UTS2
24	DHA Signaling36	12.2	KITLG, VEGFB, BMP6, UTS2, KDR, BAX
25	CREB Pathway36	12.0	KITLG, VEGFB, BMP6, UTS2, KDR, FGF1
26	PGC1Alpha Pathway36	11.9	BMP6, BAX, MEF2C, MEF2A, IL12B, IL13
27	Mitochondrial Apoptosis36	11.9	KITLG, VEGFB, VDAC1, BMP6, UTS2, KDR
28	NF-KappaB Family Pathway36	11.9	KITLG, VEGFB, MYD88, BMP6, UTS2, KDR
29	Jak-STAT signaling pathway20	11.8	PIK3CG, PIM1, JAK2, IL10, IL12B, IL13
30	mTOR Pathway36	11.7	KITLG, VEGFB, BMP6, UTS2, INS, FGF1
31	Leishmaniasis20	11.7	MYD88, JUN, JAK2, ITGB1, FOS, FCGR2A
32	Malaria20	11.7	SELP, MYD88, CD36, CD40LG, ITGAL, MET
33	JNK Pathway36	11.4	KITLG, VEGFB, BMP6, RAF1, UTS2, KDR
34	Allograft rejection20	10.9	CD40LG, IL10, IL12B, IL2, IL4, IL5
35	Autoimmune thyroid disease20	10.8	CD40LG, IL10, IL2, IL4, IL5, FASLG
36	Type I diabetes mellitus20	10.8	INS, IL12B, IL1A, IL2, FASLG, FAS
37	PEDF Induced Signaling36	INF	, BMP6, RAF1, BAX, FOS, IL10
38	Activation of PKA through GPCR36	INF	PDE3A, KITLG, , VEGFB, BMP6, RAF1
39	Calcium signaling pathway20	INF	VDAC1, , BDKRB1, BDKRB2, CHRM2, P2RX1
40	Activation of cAMP-Dependent PKA36	INF	PDE3A, KITLG, , VEGFB, BMP6, RAF1
41	Ras Pathway36	INF	, VEGFB, RAF1, UTS2, KDR, LCK
42	Colorectal Cancer Metastasis36	INF	, BIRC5, BAX, MMP1, MMP14, MMP2
43	Nanog in Mammalian ESC Pluripotency36	INF	KITLG, , VEGFB, BMP6, RAF1, UTS2
44	cAMP Pathway36	INF	PDE3A, KITLG, , VEGFB, BMP6, RAF1
45	PTEN Pathway36	INF	KITLG, , VEGFB, UTS2, KDR, LAMA2
46	STAT3 Pathway36	INF	PIM1, , BMP6, RAF1, BAX, JAK2
47	Cardiac muscle contraction20	INF	MT-CO1, , , MT-CYB, ATP2A2, ATP1A1
48	MAPK Family Pathway36	INF	KITLG, , VEGFB, BMP6, RAF1, UTS2
49	Signaling Involved in Cardiac Hypertrophy36	INF	, RAF1, JUN, JAK2, ITGAL, ITGB1
50	eIF2 Pathway36	INF	KITLG, , BMP6, RAF1, UTS2, INS

Compounds related to cardiomyopathy according to GeneDecks:

(show top 50)    (show all 477)

id	Compound	Score	Top Affiliating Genes
1	adp32 18	INF	PIK3C2A, PIK3CG, PIM1, RETN, VWF, SELP
2	carnitine32	INF	PCK2, LPL, CHKA, CHKB, MLYCD, INS
3	pyruvate32	INF	PIK3C2A, PCK2, VDAC1, CKB, CKM, CHKB
4	cysteine32	INF	PDE3A, SGCB, PCK2, PCNA, SELP, SERPINA1
5	paraffin32	INF	NCAM1, KITLG, VWF, PCNA, SERPINA1, SERPINA3
6	glucose32	INF	GCH1, NAGA, , VCL, UTS2R,
7	polyacrylamide32	INF	SERPINA1, SERPINA3, PAFAH1B1, CHKA, CHGA, CHKB
8	calcium32 9 18 9	INF	PIK3C2A, PIM1, REN, RETN, SGCB, CNR1
9	methionine32	INF	VWF, GCH1, SERPINA1, SERPINA3, VDAC1, VCL
10	norepinephrine32 9 18 9	23.3	PIK3C2A, REN, RETN, CNR1, KITLG, VWF
11	acetylcholine32 9 18 9	20.4	PIK3C2A, NCAM1, SGCB, CNR1, VWF, SERPINA3
12	aspirin32 34 18	16.8	CNR1, KITLG, VWF, PCNA, SELP, SERPINC1
13	dopamine32 9 18 9	17.4	NCAM1, REN, GCH1, SERPINA3, BMP6, RAF1
14	ryanodine32	14.1	CKM, QDPR, ATP2A2, JUP, JPH2, CDH2
15	estradiol32 9 18 9	16.5	REN, KITLG, PCNA, SERPINE1, SERPINA3, BIRC5
16	n acetylcysteine32	13.5	SGCB, VWF, PCNA, SELP, SERPINC1, RAF1
17	chloramphenicol32 9 9	15.2	PCK2, SERPINC1, SERPINE1, LPL, RAF1, CKM
18	calcitriol32 42 9 18 9	17.1	REN, KITLG, BMP6, CLU, S100A8, B2M
19	retinoid32	13.1	PCK2, BMP6, BAX, S100A8, JUN, MMP1
20	betacarotene32	12.8	VWF, PCNA, SERPINA3, LPL, CHKA, MMP1
21	peroxynitrite32	12.6	SGCB, SERPINA1, PARP1, CHKB, XDH, MPO
22	levodopa32 9 9	14.6	CNR1, KITLG, GCH1, CHGA, CHKB, QDPR
23	carvedilol32 34 9 9	15.5	REN, VEGFA, KCNH2, XDH, FKBP1B, GJA1
24	fenofibrate32 9 9	14.5	PIK3C2A, RETN, SELP, SERPINE1, LPL, CD40LG
25	caffeine32 34 9 18 9	16.4	PCNA, LPL, BMP6, CHGA, XDH, QDPR
26	histidine32	12.2	KITLG, KCNH2, CIITA, CHGA, FCGR2A, APEX1
27	lovastatin32 42 9 9	15.1	PIK3C2A, LPL, LMNA, RAF1, CHKA, CHKB
28	alpha lipoic acid32	12.0	SERPINA1, BAX, MMP9, INS, GSR, MB
29	captopril32 42 9 9	14.9	REN, BDKRB1, BDKRB2, B2M, MMP2, IL1A
30	rotenone32	11.6	PIK3CG, PARP1, MT-ND1, MT-ND6, XDH, ATP5E
31	c2ceramide32	11.6	PIK3CG, PARP1, BAX, JUN, MAPK8, MAPK14
32	melphalan32 9 9	13.4	PIK3C2A, BIRC5, CHKB, MUC16, MMP2, IL4
33	mg 13232 42	12.4	PIK3CG, PCK2, PCNA, BIRC5, PARP1, KDR
34	s-nitroso-n-acetylpenicillamine32	11.4	SGCB, PARP1, XDH, FN1, IL8, ANXA5
35	vinblastine32 9 9	13.4	RAF1, BIRC5, KDR, BAX, JUN, ITGAL
36	selenite32	11.2	BIRC5, PARP1, BAX, JUN, GSR, IL2RA
37	ifn-alpha32	11.2	IL10, IL13, IL17A, IL18, IL2, IL2RA
38	infliximab32 9 9	13.0	VEGFA, MMP1, MMP3, IL10, IL15, IL17A
39	thalidomide32 42 9 9	13.9	VEGFA, BIRC5, KDR, B2M, CD36, CD40LG
40	ciglitazone32	10.5	SERPINE1, PARP1, BAX, JUN, MMP2, MMP9
41	ceramide32	INF	CNR1, GCH1, RAF1, CHRM2, JAK2, IL18R1
42	superoxide32 18	INF	PIK3C2A, SGCB, KITLG, GCH1, SERPINA3,
43	catecholamine32	INF	PIK3C2A, REN, GCH1, CKM, CHGA, CHKB
44	adenine32 9 18 9	INF	VWF, , XDH, ATP5E, MMP3, AR
45	nadph32 18	INF	SGCB, GCH1, MYD88, UTS2, BDKRB2, SAFB
46	aspartate32	INF	PIK3C2A, RETN, CNR1, PCK2, PCNA, SELP
47	agar32	INF	KITLG, , VDAC1, BIRC5, JUP, JAK2
48	atp32	INF	PIK3C2A, PIM1, NCAM1, SGCB, PCK2, GCA
49	cytochalasin d32 42	INF	PIK3CG, KITLG, VWF, LPL, VCL, RAF1
50	dihydrotestosterone32 9 18 9	INF	SERPINE1, LPL, BMP6, CLU, CHKA, AR

Cellular components related to cardiomyopathy according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PIK3C2A, PIK3CG, PDE3A, GCH1, , VCL
2	sarcomere	GO:030017	INF	MYBPC3, , MYOZ2, TPM1, TNNI3, TNNT2
3	plasma membrane	GO:005886	INF	PIK3C2A, PIK3CG, PIM1, NCAM1, PDCD1, SGCD
4	mitochondrial inner membrane	GO:005743	INF	VDAC1, SDHA, , SCO2, IMMT,
5	integral to plasma membrane	GO:005887	16.0	SGCB, CNR1, RCE1, SELP, BDKRB1, BDKRB2
6	cell surface	GO:009986	13.0	NCAM1, VEGFA, LPL, SCN5A, MPP2, CD36
7	sarcolemma	GO:042383	12.8	SGCA, SGCB, SGCD, MYOT, SCN5A, LAMA2
8	external side of plasma membrane	GO:009897	12.4	NCAM1, VWF, SELP, KDR, B2M, CD36
9	platelet alpha granule lumen	GO:031093	12.0	VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, CLU
10	extracellular matrix	GO:031012	11.7	VWF, SERPINE1, LPL, CMA1, CLU, LAMA2
11	mitochondrion	GO:005739	INF	COA5, PCK2, VDAC1, CLU, SDHA,
12	cytoplasm	GO:005737	INF	PIK3C2A, PIK3CG, PIM1, SGCA, SGCB, SGCD
13	membrane raft	GO:045121	INF	SGCA, LCK, P2RX1, JAK2, CD36, ITGB1
14	Z disc	GO:030018	INF	MYL9, MYPN, MYOZ2, MYOT, PALLD, LDB3
15	extracellular space	GO:005615	INF	REN, KITLG, SELP, SERPINC1, SERPINA1, SERPINE1
16	perinuclear region of cytoplasm	GO:048471	INF	LMNA, MYO6, LIMS1, CMYA5, CLU, PAFAH1B1
17	extracellular region	GO:005576	INF	NCAM1, RETN, KITLG, VWF, SERPINC1, SERPINA1
18	protein complex	GO:043234	INF	GCH1, VCL, UTRN, S100A1, P2RX1, ATP2A2

Biological processes related to cardiomyopathy according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	INF	PIK3C2A, PIK3CG, PCK2, GCH1, LPL, SDHA
2	nerve growth factor receptor signaling pathway	GO:048011	INF	, MYD88, RAF1, MEF2C, MEF2A, MAPK8
3	muscle contraction	GO:006936	14.6	SGCA, VCL, MYOM1, MYOT, UTRN, UTS2
4	signal transduction	GO:007165	14.4	PDCD1, KITLG, MYD88, RAF1, UTS2R, KCNIP2
5	heart development	GO:007507	14.2	PCNA, RAF1, GYS1, IRX4, MEF2C, MEF2A
6	muscle filament sliding	GO:030049	14.0	MYBPC3, MYBPC1, MYBPC2, TPM1, TPM2, TPM3
7	response to hypoxia	GO:001666	13.9	SERPINA1, VEGFA, MYOCD, RAF1, UTS2, MMP9
8	platelet activation	GO:030168	13.7	PIK3CG, VWF, SELP, SERPINA1, SERPINE1, VEGFA
9	muscle organ development	GO:007517	13.7	SGCA, SGCB, SGCD, LMNA, UTRN, UNC45B
10	negative regulation of cell proliferation	GO:008285	13.5	MYOCD, RAF1, BDKRB2, CIB1, XIRP1, JUN
11	platelet degranulation	GO:002576	13.1	VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFB
12	cell adhesion	GO:007155	13.1	NCAM1, KITLG, VWF, SELP, VCL, MYBPC3
13	positive regulation of apoptotic process	GO:043065	13.0	CNR1, CLU, BAX, JAK2, ITGB1, MMP9
14	positive regulation of transcription from RNA polymerase II promoter	GO:045944	13.0	SERPINE1, VEGFA, MYD88, MYO6, MYOCD, BMP6
15	regulation of blood pressure	GO:008217	12.9	REN, GCH1, UTS2, CHGA, P2RX1, P2RX4
16	cell-cell signaling	GO:007267	12.9	CD70, AR, INS, IL10, IL13, IL15
17	regulation of heart contraction	GO:008016	12.8	KCNH2, KCNIP2, CHRM2, S100A1, HSPB7, CAV3
18	inflammatory response	GO:006954	12.7	PIK3CG, SELP, SERPINA3, MYD88, BMP6, BDKRB1
19	immune response	GO:006955	12.4	BMP6, CIITA, CFP, CD70, GZMA, MICB
20	cellular response to mechanical stimulus	GO:071260	12.3	MYD88, ITGB1, IL13, IL18, FAS, ANKRD1
21	ventricular cardiac muscle tissue morphogenesis	GO:055010	12.2	MYBPC3, TPM1, TNNC1, TNNI1, TNNI3, TNNT2
22	response to estradiol stimulus	GO:032355	12.2	SERPINA1, MMP9, CALR, CASP8, ESR1, GH1
23	cell surface receptor signaling pathway	GO:007166	12.2	MYD88, BDKRB2, CD36, MET, IL2RA, MAPK14
24	sarcomere organization	GO:045214	12.1	MYPN, XIRP1, ITGB1, ANKRD1, TPM1, SRF
25	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.1	KITLG, VEGFA, VEGFB, JAK2, CD36, ITGB1
26	positive regulation of inflammatory response	GO:050729	11.9	SERPINE1, JAK2, IL12B, IL15, IL18, IL2
27	response to lipopolysaccharide	GO:032496	11.8	CNR1, GCH1, SELP, SERPINA1, BDKRB1, S100A8
28	positive regulation of MAPK cascade	GO:043410	11.7	KDR, CD36, CDH2, ITGB1, FLT1, AR
29	response to organic cyclic compound	GO:014070	11.5	SELP, SERPINA1, FXN, JUN, MET, IL1A
30	MyD88-dependent toll-like receptor signaling pathway	GO:002755	11.5	MYD88, JUN, FOS, MEF2C, MEF2A, MAPK8
31	toll-like receptor 1 signaling pathway	GO:034130	11.2	MYD88, JUN, FOS, MEF2C, MEF2A, MAPK8
32	toll-like receptor 2 signaling pathway	GO:034134	11.1	MYD88, JUN, FOS, MEF2C, MEF2A, MAPK8
33	angiogenesis	GO:001525	11.1	PIK3CG, SERPINE1, VEGFA, KDR, JUN, MMP2
34	interferon-gamma-mediated signaling pathway	GO:060333	11.1	NCAM1, CIITA, B2M, JAK2, IFNG, CAMK2D
35	positive regulation of smooth muscle cell proliferation	GO:048661	11.1	MYD88, JUN, FLT1, IL13, IL6, IL6R
36	Toll signaling pathway	GO:008063	11.0	MYD88, JUN, FOS, MEF2C, MEF2A, MAPK8
37	positive regulation of angiogenesis	GO:045766	10.6	SERPINE1, VEGFA, UTS2, UTS2R, KDR, CD34
38	positive regulation of cell proliferation	GO:008284	INF	VEGFA, MYOCD, BIRC5, KDR, FXN, FTMT
39	negative regulation of apoptotic process	GO:043066	INF	PIK3CG, PIM1, PDE3A, SERPINE1, , VEGFA
40	cardiac muscle contraction	GO:060048	INF	VEGFB, MYBPC3, , SCN5A, MAP2K6, CAMK2D
41	cytokine-mediated signaling pathway	GO:019221	INF	NCAM1, MYD88, CIITA, B2M, JAK2, IL1A
42	positive regulation of MAP kinase activity	GO:043406	INF	PIK3CG, KITLG, VEGFA, FLT1, ILK, HTR2A
43	blood coagulation	GO:007596	INF	PIK3CG, PDE3A, VWF, SELP, SERPINC1, SERPINA1
44	aging	GO:007568	INF	CNR1, JUN, , IL15, FAS, CCL2
45	positive regulation of cell migration	GO:030335	INF	VEGFA, KDR, JAK2, ITGB1, MMP14, FLT1
46	apoptotic process	GO:006915	INF	PIM1, PDCD1, VDAC1, LMNA, LMNB1, RAF1
47	anti-apoptosis	GO:006916	INF	, VEGFB, MYD88, BIRC5, BIRC6, BAG3
48	response to ethanol	GO:045471	INF	CNR1, S100A8, FYN, MMP9, , IL13
49	response to drug	GO:042493	INF	PDE3A, REN, LPL, UTS2, UTS2R, BDKRB2
50	glucose metabolic process	GO:006006	INF	PCK2, GYS1, INS, MAPK14, IGF2, CALM3

Molecular functions related to cardiomyopathy according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein heterodimerization activity	GO:046982	INF	PGF, ADRA2C, ADORA2A, ADORA1, ADRB1, HAND1
2	receptor binding	GO:005102	14.0	SERPINE1, LPL, UTS2, LAMA2, LAMA4, P2RX4
3	structural constituent of muscle	GO:008307	13.6	TPM4, DMD, DAG1, PDLIM3, KRT19, ACTN2
4	identical protein binding	GO:042802	12.6	ACTN2, EGFR, COL1A2, COL1A1, SUN2, TNF
5	hormone activity	GO:005179	12.4	PRL, POMC, NPPA, NPPB, NPPC, ADM
6	protease binding	GO:002020	11.5	HSPA1B, TP53, TNF, TNFRSF1A, TTN, POLG
7	growth factor activity	GO:008083	11.3	GH1, PPBP, PDGFB, HBEGF, AGT, TGFB1
8	integrin binding	GO:005178	11.2	LTBP4, ACTN2, ACTN1, GFAP, TIMP2, THBS1
9	cytokine activity	GO:005125	11.1	IL15, IL17A, IL17D, IL18, IL1A, IL2
10	protein binding	GO:005515	INF	PRKAA2, SLC9A1, SLC22A5, SLC6A4, RYR2, RUNX1
11	enzyme binding	GO:019899	INF	DFFB, TGFB1, TTN, HIF1A, EGFR, PDE4DIP
12	protein homodimerization activity	GO:042803	INF	S100A1, HLA-G, TXNRD2, TNNC1, PTGS2, SRF
13	actin binding	GO:003779	INF	DAG1, DMD, TNNT2, TNNI3, TNNI1, TPM4