MCID: CRD011
MIFTS: 67

Cardiomyopathy

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Neuronal diseases, Ear diseases

Aliases & Classifications for Cardiomyopathy

MalaCards integrated aliases for Cardiomyopathy:

Name: Cardiomyopathy 24 29 52 41 3
Cardiomyopathies 69

Classifications:



External Ids:

ICD10 33 I42

Summaries for Cardiomyopathy

MedlinePlus : 41 cardiomyopathy is the name for diseases of the heart muscle. these diseases enlarge your heart muscle or make it thicker and more rigid than normal. in rare cases, scar tissue replaces the muscle tissue. some people live long, healthy lives with cardiomyopathy. some people don't even realize they have it. in others, however, it can make the heart less able to pump blood through the body. this can cause serious complications, including heart failure abnormal heart rhythms heart valve problems sudden cardiac arrest heart attacks, high blood pressure, infections, and other diseases can all cause cardiomyopathy. some types of cardiomyopathy run in families. in many people, however, the cause is unknown. treatment might involve medicines, surgery, other medical procedures, and lifestyle changes. nih: national heart, lung, and blood institute

MalaCards based summary : Cardiomyopathy, also known as cardiomyopathies, is related to ventricular tachycardia, catecholaminergic polymorphic, 1 and left ventricular noncompaction 10, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Cardiomyopathy is LMNA (Lamin A/C), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Vascular smooth muscle contraction. The drugs Eplerenone and Spironolactone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

CDC : 3 Cardiomyopathy represents a collection of diverse conditions of the heart muscle. These diseases have many causes, symptoms, and treatments and can affect people of all ages and races.

Wikipedia : 72 Cardiomyopathy is a group of diseases that affect the heart muscle. Early on there may be few or no... more...

Related Diseases for Cardiomyopathy

Diseases in the Cardiomyopathy family:

Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1a
Cardiomyopathy, Dilated, 1v Cardiomyopathy, Dilated, 1d
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 1z Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1gg Cardiomyopathy, Dilated, 1l
Cardiomyopathy, Dilated, 1k Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1p Cardiomyopathy, Dilated, 1j
Cardiomyopathy, Dilated, 2b Cardiomyopathy, Dilated, 1q
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1u
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 3b Dilated Cardiomyopathy
Dmd-Related Dilated Cardiomyopathy Dilated Cardiomyopathy 1c
Dilated Cardiomyopathy 1aa Dilated Cardiomyopathy 1b
Dilated Cardiomyopathy 1t Lmna-Related Dilated Cardiomyopathy
Cardiomyopathy Due to Anthracyclines Mypn-Related Cardiomyopathy
Abcc9-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Actn2-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Cryab-Related Dilated Cardiomyopathy
Csrp3-Related Dilated Cardiomyopathy Des-Related Dilated Cardiomyopathy
Dsg2-Related Dilated Cardiomyopathy Eya4-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Gatad1-Related Dilated Cardiomyopathy
Lama4-Related Dilated Cardiomyopathy Ldb3-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
Myh7-Related Dilated Cardiomyopathy Nexn-Related Dilated Cardiomyopathy
Pln-Related Dilated Cardiomyopathy Prdm16-Related Dilated Cardiomyopathy
Psen1-Related Dilated Cardiomyopathy Psen2-Related Dilated Cardiomyopathy
Rbm20-Related Dilated Cardiomyopathy Scn5a-Related Dilated Cardiomyopathy
Sdha-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Taz-Related Dilated Cardiomyopathy Tcap-Related Dilated Cardiomyopathy
Tmpo-Related Dilated Cardiomyopathy Tnnc1-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Tnnt2-Related Dilated Cardiomyopathy
Tpm1-Related Dilated Cardiomyopathy Ttn-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy

Diseases related to Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)
id Related Disease Score Top Affiliating Genes
1 ventricular tachycardia, catecholaminergic polymorphic, 1 33.4 DSG2 LMNA MYH7
2 left ventricular noncompaction 10 33.2 MYBPC3 TTN
3 atrial standstill, digenic 32.3 ACTN2 DSG2 LAMP2 LMNA MYBPC3 PLN
4 aortic aneurysm 30.9 ACTC1 DES
5 ectodermal dysplasia 30.9 ACTC1 ACTN2 DES DMD LAMP2 LMNA
6 sudden infant death syndrome 30.9 DES LMNA MYH7 TPM1
7 congenital myopathy 30.2 DMD TTN
8 dilated cardiomyopathy 12.3
9 infantile histiocytoid cardiomyopathy 12.2
10 restrictive cardiomyopathy 12.2
11 cardiomyopathy, familial hypertrophic 12.2
12 peripartum cardiomyopathy 12.1
13 cardiomyopathy, dilated, 1e 12.1
14 alcoholic cardiomyopathy 12.1
15 arrhythmogenic right ventricular cardiomyopathy 12.1
16 cardiomyopathy, dilated, 1kk 12.0
17 cardiomyopathy, dilated, 3b 12.0
18 cardiomyopathy, dilated, with woolly hair and keratoderma 12.0
19 cardiomyopathy, dilated, 1x 12.0
20 cardiomyopathy, dilated, 1o 12.0
21 cardiomyopathy, dilated, 1l 12.0
22 cardiomyopathy, dilated, 1j 11.9
23 cardiomyopathy, dilated, 1g 11.9
24 cardiomyopathy, dilated, 1p 11.9
25 cardiomyopathy, dilated, 1cc 11.9
26 cardiomyopathy, dilated, 1v 11.9
27 cardiomyopathy, dilated, 1d 11.9
28 cardiomyopathy, dilated, 1i 11.9
29 cardiomyopathy, dilated, 1z 11.9
30 cardiomyopathy, dilated, 1gg 11.9
31 cardiomyopathy, dilated, 1jj 11.9
32 cardiomyopathy, dilated, 2b 11.9
33 cardiomyopathy, dilated, 1w 11.9
34 cardiomyopathy, dilated, 1dd 11.9
35 cardiomyopathy, dilated, 1hh 11.9
36 cardiomyopathy, dilated, 1m 11.9
37 cardiomyopathy, dilated, 1ii 11.9
38 cardiomyopathy, dilated, 1ee 11.9
39 cardiomyopathy, dilated, 1u 11.9
40 cardiomyopathy, dilated, 1r 11.9
41 cardiomyopathy, dilated, 1bb 11.9
42 cardiomyopathy, dilated, 2a 11.9
43 cardiomyopathy, dilated, 1ff 11.9
44 microcephaly-cardiomyopathy 11.9
45 cardiomyopathy, dilated, 1a 11.9
46 cardiomyopathy, dilated, 1nn 11.9
47 cardiomyopathy, dilated, 1h 11.9
48 familial amyloid cardiomyopathy 11.9
49 cardiomyopathy, hypertrophic, 8 11.9
50 dilated cardiomyopathy 1c 11.9

Comorbidity relations with Cardiomyopathy via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Cardiomyopathy:



Diseases related to Cardiomyopathy

Symptoms & Phenotypes for Cardiomyopathy

UMLS symptoms related to Cardiomyopathy:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Cardiomyopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 DES TNNI3 DMD TNNT2 LAMP2 TTN
2 homeostasis/metabolism MP:0005376 9.9 MYL2 DES DMD TNNT2 LAMP2 TTN
3 mortality/aging MP:0010768 9.77 MYL2 SCN1B DES TNNI3 DMD TNNT2
4 muscle MP:0005369 9.44 DES TNNI3 DMD TNNT2 LAMP2 TTN

Drugs & Therapeutics for Cardiomyopathy

Drugs for Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 486)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4,Phase 3,Phase 1 107724-20-9 150310 443872
2
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1 1952-01-7, 52-01-7 5833
3
Carvedilol Approved, Investigational Phase 4,Phase 2 72956-09-3 2585
4
Verapamil Approved Phase 4 52-53-9 2520
5
Amlodipine Approved Phase 4 88150-42-9 2162
6
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
7
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137862-53-4 60846
8
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2 142387-99-3, 95635-55-5 56959
9
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541
10
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
12
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
13
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3 37350-58-6, 51384-51-1 4171
14
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
15
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
16
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 1
17
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
18
Doxazosin Approved Phase 4 74191-85-8 3157
19
Deferiprone Approved Phase 4 30652-11-0 2972
20
Deferoxamine Approved, Investigational Phase 4 70-51-9 2973
21
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
22
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
23
Captopril Approved Phase 4,Phase 1 62571-86-2 44093
24
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
25
Ramipril Approved Phase 4 87333-19-5 5362129
26
Trandolapril Approved Phase 4 87679-37-6 5484727
27
Darbepoetin alfa Approved, Investigational Phase 4,Phase 3 11096-26-7, 209810-58-2
28
Digoxin Approved Phase 4 20830-75-5 30322 2724385
29
Allopurinol Approved Phase 4,Phase 1,Phase 2 315-30-0 2094
30
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
31
Remifentanil Approved Phase 4 132875-61-7 60815
32
Sevoflurane Approved, Vet_approved Phase 4,Phase 1,Phase 2 28523-86-6 5206
33
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
34
Cilostazol Approved Phase 4 73963-72-1 2754
35
Adenosine Approved, Investigational Phase 4,Phase 1,Phase 2 58-61-7 60961
36
Regadenoson Approved Phase 4,Phase 2 313348-27-5 219024
37
Dobutamine Approved Phase 4,Phase 3,Phase 1,Phase 2 34368-04-2 36811
38
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
39
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
40
Selenious acid Approved Phase 4 7783-00-8
41
Selenium Approved, Vet_approved Phase 4,Phase 3 7782-49-2
42
Milrinone Approved Phase 4,Phase 2,Phase 1 78415-72-2 4197
43
Tadalafil Approved, Investigational Phase 4,Phase 1,Phase 2 171596-29-5 110635
44
Empagliflozin Approved Phase 4,Phase 3 864070-44-0
45
Glimepiride Approved Phase 4 93479-97-1 3476
46
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1 54-31-9 3440
47
Metolazone Approved Phase 4,Phase 1 17560-51-9 4170
48
Chlorthalidone Approved Phase 4 77-36-1 2732
49
Propafenone Approved Phase 4,Phase 3 54063-53-5 4932
50
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253

Interventional clinical trials:

(show top 50) (show all 995)

id Name Status NCT ID Phase Drugs
1 CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone Unknown status NCT00401856 Phase 4 Eplerenone;Placebo
2 Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy Unknown status NCT00348530 Phase 4 Verapamil
3 Identification of Carnitine-Responsive Cardiomyopathy Unknown status NCT01904396 Phase 4 Carnitine
4 Therapy With Verapamil or Carvedilol in Chronic Heart Failure Unknown status NCT00374465 Phase 4 Verapamil;Carvedilol
5 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4 spironolactone
6 Danish ICD Study in Patients With Dilated Cardiomyopathy Unknown status NCT00542945 Phase 4
7 Revascularization in Heart Failure Trial – REHEAT 2 Unknown status NCT00388245 Phase 4
8 The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy Unknown status NCT00606775 Phase 4 Carvedilol
9 Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary Exercise Capacity Unknown status NCT00326690 Phase 4
10 Evaluation of Efficacy and Safety of Agalsidase Beta in Heterozygous Females for Fabry Disease Unknown status NCT00487630 Phase 4 recombinant alpha-galactosidase A
11 Effects of Spironolactone in Dialysis Unknown status NCT01128101 Phase 4 Spironolactone
12 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
13 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
14 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4 Ranolazine (Active drug);Placebo
15 A Strategy of Home Telehealth for Management of Congestive Heart Failure(STARTEL) Unknown status NCT00247000 Phase 4
16 Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy Completed NCT02115581 Phase 4 Coenzyme Q10;Placebo
17 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
18 Exercise Training in Chagas Cardiomyopathy Completed NCT01006473 Phase 4
19 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
20 Ranolazine in Ischemic Cardiomyopathy Completed NCT01345188 Phase 4 Ranexa;Placebo
21 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Completed NCT01293903 Phase 4 Qiliqiangxin capsule;Placebo
22 Ranolazine for the Treatment of Chest Pain in HCM Patients Completed NCT01721967 Phase 4 Ranolazine
23 Statin Therapy for Ischemic and Nonischemic Cardiomyopathy Completed NCT00701220 Phase 4 Atorvastatin Calcium
24 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
25 Aspirin Withdrawal in Non-ischaemic Cardiomyopathy Study Completed NCT01534026 Phase 4 Aspirin
26 Chronic, Low Dose Erythropoetin Beta in Ischemic Cardiomyopathy Completed NCT00568542 Phase 4 erythropoetin beta;placebo
27 PACMAN - PAcing for CardioMyopathies, a EuropeAN Study Completed NCT00180596 Phase 4
28 Spironolactone Against Anthracycline-induced Cardiomyopathy Completed NCT02053974 Phase 4 Spironolactone
29 Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart Completed NCT01798992 Phase 4 Carvedilol;Metoprolol succinate;Metoprolol succinate + doxazosin
30 ACC - Atrial Contribution to CRT Completed NCT00180323 Phase 4
31 Impact of Nesiritide Infusion for Decompensated Heart Failure in the Emergency Department Completed NCT00559338 Phase 4 recombinant B-type, natriuretic peptide;placebo
32 Clinical Evaluation on Advanced Resynchronization Completed NCT00658203 Phase 4
33 123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging on a Small Field of View-High Efficiency Cardiac SPECT System Completed NCT01868841 Phase 4
34 Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure Completed NCT01261065 Phase 4 carvedilol
35 Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major Completed NCT00800761 Phase 4 Deferoxamine and Deferiprone;Deferoxamine
36 Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Completed NCT00391846 Phase 4 Captopril;Enalapril;Lisinopril;Ramipril;Trandolapril;Bisoprolol;Carvedilol;Metoprolol succinate;Candesartan;Valsartan;Eplerenone;Spironolactone;Diuretics;HF treatment according to Swedish guidelines
37 Myocardial Glucose Uptake (MGU) in Patients With Chronic Kidney Disease Completed NCT00883415 Phase 4 Darbepoetin alfa
38 Spanish Atrial Fibrillation And Resynchronization Study Completed NCT01181414 Phase 4 Beta blocker/digoxine/amiodarone
39 Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients Completed NCT00477789 Phase 4 allopurinol
40 Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients Completed NCT00128024 Phase 4 lipid-lowering treatment
41 Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes Completed NCT00692237 Phase 4 Sildenafil;Placebo
42 Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS) Completed NCT00371891 Phase 4
43 Statin Therapy in Heart Failure: Potential Mechanisms of Benefit Completed NCT00233480 Phase 4 atorvastatin;placebo
44 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
45 Prevention of CHOP-induced Chronic Cardiotoxicity Completed NCT00162955 Phase 4 Valsartan
46 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
47 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
48 Myocardial Protection and Anesthetic Agents Completed NCT02405689 Phase 4 Remifentanil;Dexmedetomidine;Sevoflurane
49 Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit) Completed NCT01601795 Phase 4 Sevoflurane;Isoflurane
50 ACCEL-LOADING-ACS Study Completed NCT01354808 Phase 4 Dual Anti-Platelet Therapy (DAPT);Triple Anti-Platelet Therapy (TAPT)

Search NIH Clinical Center for Cardiomyopathy

Genetic Tests for Cardiomyopathy

Genetic tests related to Cardiomyopathy:

id Genetic test Affiliating Genes
1 Cardiomyopathy 29 24

Anatomical Context for Cardiomyopathy

MalaCards organs/tissues related to Cardiomyopathy:

39
Heart, Testes, Brain, Bone, Skeletal Muscle, Liver, Lung

Publications for Cardiomyopathy

Articles related to Cardiomyopathy:

(show top 50) (show all 6891)
id Title Authors Year
1
Acute pulmonary edema caused by takotsubo cardiomyopathy in a pregnant woman undergoing transvaginal cervical cerclage: A case report. ( 28072695 )
2017
2
The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy. ( 28430627 )
2017
3
Treatment With Tafamidis Slows Disease Progression in Early-Stage Transthyretin Cardiomyopathy. ( 28951660 )
2017
4
Hypertrophic obstructive cardiomyopathy. ( 28944188 )
2017
5
Comparison of Pulmonary Venous and Left Atrial Remodeling in Patients With Atrial Fibrillation With Hypertrophic Cardiomyopathy Versus With Hypertensive Heart Disease. ( 28214001 )
2017
6
Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations. ( 28296734 )
2017
7
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis. ( 28359509 )
2017
8
An abnormal chord inserting to a subaortic membrane in hypertrophic cardiomyopathy: rare anatomical combination. ( 28950353 )
2017
9
Novel Dominant-Negative Mutation in Cardiac Troponin I Causes Severe Restrictive Cardiomyopathy. ( 28174160 )
2017
10
Wnt/I^-catenin pathway in arrhythmogenic cardiomyopathy. ( 28948000 )
2017
11
Characteristics of cardiomyopathy in AlstrAPm syndrome: Prospective single-center data on 38 patients. ( 28610912 )
2017
12
Arrhythmogenic Right Ventricular Cardiomyopathy. ( 28402769 )
2017
13
Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes. ( 28082330 )
2017
14
CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy. ( 28874395 )
2017
15
Clinical features of idiopathic restrictive cardiomyopathy: A retrospective multicenter cohort study over 2 decades. ( 28885342 )
2017
16
Takotsubo cardiomyopathy associated with Paragonimiasis westermani. ( 28884631 )
2017
17
Genotype-specific pathogenic effects in human dilated cardiomyopathy. ( 28436080 )
2017
18
Peripartum cardiomyopathy in Denmark: a retrospective, population-based study of incidence, management and outcome. ( 28597481 )
2017
19
Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion. ( 28431057 )
2017
20
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. ( 28081170 )
2017
21
Co segregation of the m.1555A>G mutation in the MT-RNR1 gene and mutations in MT-ATP6 gene in a family with dilated mitochondrial cardiomyopathy and hearing loss: A whole mitochondrial genome screening. ( 28104394 )
2017
22
Mitochondrial Cardiomyopathy with a Unique (99m)Tc-MIBI/(123)I-BMIPP Mismatch Pattern. ( 28154277 )
2017
23
Electrical Storm in ICD Recipients with Arrhythmogenic Right Ventricular Cardiomyopathy. ( 28261825 )
2017
24
Comparison of clinical outcomes in peripartum cardiomyopathy and age-matched dilated cardiomyopathy: A 15-year nationwide population-based study in Asia. ( 28489799 )
2017
25
Continuous-flow, implantable biventricular assist device as bridge to cardiac transplantation in a small child with restrictive cardiomyopathy. ( 28843949 )
2017
26
Autosomal Recessive Nonsyndromic Arrhythmogenic Right Ventricular Cardiomyopathy without Cutaneous Involvements: A Novel Mutation. ( 28523642 )
2017
27
Identification of Fabry Disease in a Tertiary Referral Cohort of Patients with Hypertrophic Cardiomyopathy. ( 28943383 )
2017
28
Advances in Diagnosis and Management of Mitochondrial Cardiomyopathy. ( 28483032 )
2017
29
Echocardiographic Strain Analysis for the Early Detection of Myocardial Structural Abnormality and Initiation of Drug Therapy in a Mouse Model of Dilated Cardiomyopathy. ( 28942269 )
2017
30
Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease. ( 28819918 )
2017
31
Isolated septal myectomy for hypertrophic obstructive cardiomyopathy: an update on the Toronto General Hospital experience. ( 28944177 )
2017
32
Contraception and reproductive counseling in women with peripartum cardiomyopathy. ( 28578148 )
2017
33
Novel findings of left ventricular non-compaction cardiomyopathy, microform cleft lip and poor vision in patient with SMC1A-associated Cornelia de Lange syndrome. ( 28102598 )
2017
34
Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function. ( 28934278 )
2017
35
Re: Myocardial Recovery in Peripartum Cardiomyopathy after Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28114195 )
2017
36
A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure. ( 28700929 )
2017
37
Sudden cardiac death in isolated right ventricular hypertrabeculation/noncompaction cardiomyopathy. ( 28901675 )
2017
38
Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach. ( 28515850 )
2017
39
Renin-angiotensin system gene polymorphisms as potential modifiers of hypertrophic and dilated cardiomyopathy phenotypes. ( 28120210 )
2017
40
Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome. ( 28329361 )
2017
41
Addressing Health Disparities in Idiopathic Dilated Cardiomyopathy. ( 28868530 )
2017
42
Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (I^-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy. ( 28193612 )
2017
43
Left ventricular noncompaction cardiomyopathy in a patient with trisomy 13: A report and review of the literature. ( 28488311 )
2017
44
Incidental finding of single coronary artery in a patient with alcoholic cardiomyopathy presenting as acute heart failure. ( 28126699 )
2017
45
Reducing the risks for relapse of heart failure in a subsequent pregnancy after peripartum cardiomyopathy? ( 28621169 )
2017
46
Concomitant ablation for atrial fibrillation during septal myectomy in patients with hypertrophic obstructive cardiomyopathy. ( 28947201 )
2017
47
Prevalence and Spectrum of NKX2-5 Mutations Associated With Sporadic Adult-Onset Dilated Cardiomyopathy. ( 28690296 )
2017
48
Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. ( 28934837 )
2017
49
Myofilament remodeling and function is more impaired in peripartum cardiomyopathy compared to dilated cardiomyopathy and ischemic heart disease. ( 28935576 )
2017
50
MEF2C loss-of-function mutation associated with familial dilated cardiomyopathy. ( 28902616 )
2017

Variations for Cardiomyopathy

ClinVar genetic disease variations for Cardiomyopathy:

6 (show all 36)
id Gene Variation Type Significance SNP ID Assembly Location
1 TNNT2 NM_001001430.2(TNNT2): c.421C> T (p.Arg141Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315379 GRCh37 Chromosome 1, 201333464: 201333464
2 TNNI3 NM_000363.4(TNNI3): c.575G> A (p.Arg192His) single nucleotide variant Pathogenic/Likely pathogenic rs104894729 GRCh37 Chromosome 19, 55663260: 55663260
3 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh37 Chromosome 18, 29178618: 29178618
4 MYBPC3 NM_000256.3(MYBPC3): c.2311dupG (p.Val771Glyfs) duplication Pathogenic rs397515960 GRCh37 Chromosome 11, 47359343: 47359343
5 MYBPC3 NM_000256.3(MYBPC3): c.2534_2538delGCGTC (p.Arg845Leufs) deletion Pathogenic rs397515973 GRCh37 Chromosome 11, 47359006: 47359010
6 MYH7 NM_000257.3(MYH7): c.1106G> A (p.Arg369Gln) single nucleotide variant Likely pathogenic rs397516089 GRCh37 Chromosome 14, 23899016: 23899016
7 MYH7 NM_000257.3(MYH7): c.5401G> A (p.Glu1801Lys) single nucleotide variant Likely pathogenic rs397516248 GRCh37 Chromosome 14, 23884362: 23884362
8 PLN NM_002667.4(PLN): c.40_42delAGA (p.Arg14del) deletion Pathogenic rs397516784 GRCh37 Chromosome 6, 118880124: 118880126
9 LMNA NM_170707.3(LMNA): c.1304_1307dupGCAC (p.Ser437Hisfs) duplication Pathogenic rs267607577 GRCh37 Chromosome 1, 156106151: 156106154
10 MYH7 NM_000257.3(MYH7): c.1573G> A (p.Glu525Lys) single nucleotide variant Pathogenic/Likely pathogenic rs606231324 GRCh37 Chromosome 14, 23897714: 23897714
11 ACTN2 NM_001103.3(ACTN2): c.355G> A (p.Ala119Thr) single nucleotide variant Pathogenic rs727502886 GRCh37 Chromosome 1, 236882307: 236882307
12 DSP NM_004415.3(DSP): c.939+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs727504443 GRCh37 Chromosome 6, 7565754: 7565754
13 DSP NM_004415.3(DSP): c.3630T> A (p.Tyr1210Ter) single nucleotide variant Pathogenic/Likely pathogenic rs727503001 GRCh37 Chromosome 6, 7580053: 7580053
14 MYBPC3 NM_000256.3(MYBPC3): c.1351+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs727503204 GRCh38 Chromosome 11, 47343020: 47343020
15 MYBPC3 NM_000256.3(MYBPC3): c.3776delA (p.Gln1259Argfs) deletion Pathogenic/Likely pathogenic rs727503166 GRCh37 Chromosome 11, 47353661: 47353661
16 MYH7 NM_000257.3(MYH7): c.4498C> T (p.Arg1500Trp) single nucleotide variant Pathogenic/Likely pathogenic rs45544633 GRCh37 Chromosome 14, 23886383: 23886383
17 MYH7 NM_000257.3(MYH7): c.2302G> A (p.Gly768Arg) single nucleotide variant Pathogenic/Likely pathogenic rs727503260 GRCh37 Chromosome 14, 23894612: 23894612
18 MYH7 NM_000257.3(MYH7): c.1157A> G (p.Tyr386Cys) single nucleotide variant Likely pathogenic rs727503269 GRCh37 Chromosome 14, 23898538: 23898538
19 TNNI3 NM_000363.4(TNNI3): c.509G> A (p.Arg170Gln) single nucleotide variant Pathogenic/Likely pathogenic rs727503503 GRCh37 Chromosome 19, 55665438: 55665438
20 MYBPC3 NM_000256.3(MYBPC3): c.1038_1042dupCGGCA (p.Met348Thrfs) duplication Pathogenic rs730880336 GRCh38 Chromosome 11, 47346255: 47346259
21 TNNT2 NM_001001430.2(TNNT2): c.814dupC (p.Gln272Profs) duplication Pathogenic rs730881119 GRCh38 Chromosome 1, 201359630: 201359630
22 MYBPC3 NM_000256.3(MYBPC3): c.3472_3481delGTCTTTATCC (p.Val1158Profs) deletion Pathogenic rs730880675 GRCh38 Chromosome 11, 47332823: 47332832
23 MYBPC3 NM_000256.3(MYBPC3): c.3327delC (p.Met1110Trpfs) deletion Pathogenic rs730880719 GRCh38 Chromosome 11, 47333197: 47333197
24 MYBPC3 NM_000256.3(MYBPC3): c.3302_3303delCA (p.Thr1101Serfs) deletion Pathogenic rs730880671 GRCh37 Chromosome 11, 47354772: 47354773
25 MYBPC3 NM_000256.3(MYBPC3): c.3182_3190+4del deletion Pathogenic rs730880718 GRCh37 Chromosome 11, 47355104: 47355116
26 MYBPC3 NM_000256.3(MYBPC3): c.2894_2905+4del deletion Pathogenic rs730880717 GRCh38 Chromosome 11, 47335038: 47335053
27 MYBPC3 NM_000256.3(MYBPC3): c.2604delT (p.Ser871Alafs) deletion Pathogenic rs730880655 GRCh37 Chromosome 11, 47357561: 47357561
28 MYBPC3 NM_000256.3(MYBPC3): c.2543delC (p.Ala848Glyfs) deletion Pathogenic rs730880715 GRCh38 Chromosome 11, 47337450: 47337450
29 MYBPC3 NM_000256.3(MYBPC3): c.2382delG (p.Pro795Leufs) deletion Pathogenic rs730880714 GRCh37 Chromosome 11, 47359272: 47359272
30 MYBPC3 NM_000256.3(MYBPC3): c.1358dupC (p.Val454Cysfs) duplication Pathogenic/Likely pathogenic rs730880711 GRCh37 Chromosome 11, 47364480: 47364480
31 MYBPC3 NM_000256.3(MYBPC3): c.1156_1171dup16 (p.Asp391Glyfs) duplication Pathogenic rs730880689 GRCh38 Chromosome 11, 47343544: 47343559
32 MYBPC3 NM_000256.3(MYBPC3): c.1120dupC (p.Gln374Profs) duplication Pathogenic rs730880688 GRCh38 Chromosome 11, 47343595: 47343595
33 LAMP2 NM_002294.2(LAMP2): c.588_589insCAACA (p.Val197Glnfs) insertion Pathogenic rs730880492 GRCh38 Chromosome X, 120447993: 120447994
34 MYBPC3 NM_000256.3: c.3315delG deletion Pathogenic
35 DSG2 NM_001943.4(DSG2): c.86_87delTAinsATTCTATTGTTGTGCTATTGTTAT (p.Leu29Tyrfs) indel Pathogenic rs794728100 GRCh37 Chromosome 18, 29099770: 29099771
36 SCN1B NM_199037.4(SCN1B): c.308A> T (p.Asp103Val) single nucleotide variant Pathogenic rs1057519457 GRCh38 Chromosome 19, 35033599: 35033599

Copy number variations for Cardiomyopathy from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 20789 1 154318992 154376502 Deletion LMNA Cardiomyopathy
2 39890 10 121400871 121427319 Deletion BAG3 Cardiomyopathy
3 139275 2 178000000 180600000 Loss TTN Cardiomyopathy
4 140112 2 191900000 197400000 Loss HSP40 Cardiomyopathy
5 262125 X 31047265 33267647 Deletion DMD Cardiomyopathy

Expression for Cardiomyopathy

Search GEO for disease gene expression data for Cardiomyopathy.

Pathways for Cardiomyopathy

Pathways related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 ACTN2 MYH6 MYH7 MYL2 VCL
2
Show member pathways
12.72 ACTC1 MYH6 MYH7 MYL2 PLN PRKAG2
3
Show member pathways
12.5 ACTN2 DES DMD MYBPC3 MYH6 MYL2
4
Show member pathways
12.47 ACTC1 ACTN2 MYH6 MYH7 MYL2 VCL
5 12.4 ACTC1 DES LMNA TNNI3 TNNT2 TPM1
6
Show member pathways
12.29 ACTN2 DES DMD DSG2 LMNA VCL
7
Show member pathways
12.19 MYH6 MYH7 MYL2 VCL
8
Show member pathways
12.14 ACTN2 MYH6 MYH7 MYL2
9 11.68 DES TNNI3 TNNT2
10 11.59 ACTC1 MYH6 MYH7 MYL2 TNNI3 TNNT2
11 11.45 MYH6 MYH7 PRKAG2
12 11.44 ACTC1 MYH6 MYL2 TNNI3 TNNT2
13 11.38 LMNA PLN SCN1B
14 11.22 ACTC1 ACTN2 DES DMD MYBPC3 MYH6

GO Terms for Cardiomyopathy

Cellular components related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.73 ACTN2 DES DMD MYBPC3 MYH7 TTN
2 filopodium GO:0030175 9.71 ACTC1 ACTN2 DMD
3 actin filament GO:0005884 9.7 ACTC1 ACTN2 TPM1
4 myosin complex GO:0016459 9.67 MYH6 MYH7 MYL2
5 intercalated disc GO:0014704 9.65 DES DSG2 SCN1B
6 costamere GO:0043034 9.59 DMD VCL
7 A band GO:0031672 9.58 MYBPC3 MYL2
8 contractile fiber GO:0043292 9.58 DES TNNI3
9 sarcolemma GO:0042383 9.57 DES DMD
10 fascia adherens GO:0005916 9.55 DES VCL
11 cardiac myofibril GO:0097512 9.55 DES MYBPC3 MYL2 TNNI3 TNNT2
12 muscle myosin complex GO:0005859 9.54 MYH6 MYH7 TTN
13 troponin complex GO:0005861 9.51 TNNI3 TNNT2
14 myosin filament GO:0032982 9.5 MYBPC3 MYH6 MYH7
15 myofibril GO:0030016 9.5 DMD MYH6 MYH7 MYL2 TNNI3 TNNT2
16 cell-substrate junction GO:0030055 9.46 DMD VCL
17 cardiac Troponin complex GO:1990584 9.43 TNNI3 TNNT2
18 sarcomere GO:0030017 9.28 ACTC1 ACTN2 MYBPC3 MYH6 MYH7 MYL2
19 cytosol GO:0005829 10.25 ACTC1 ACTN2 DES DMD LMNA MYBPC3
20 cytoskeleton GO:0005856 10.1 ACTC1 ACTN2 DES DMD MYL2 TPM1

Biological processes related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.86 ACTN2 DES MYH6 MYH7 TNNT2 TPM1
2 platelet degranulation GO:0002576 9.84 ACTN2 LAMP2 TTN VCL
3 sarcomere organization GO:0045214 9.8 ACTN2 MYBPC3 MYH6 TPM1 TTN
4 regulation of heart contraction GO:0008016 9.77 DES MYH6 PLN TNNT2 TPM1
5 regulation of the force of heart contraction GO:0002026 9.73 MYH6 MYH7 MYL2 PLN
6 muscle filament sliding GO:0030049 9.73 ACTC1 ACTN2 DES DMD MYBPC3 MYH6
7 positive regulation of ATPase activity GO:0032781 9.72 MYBPC3 TNNT2 TPM1
8 striated muscle contraction GO:0006941 9.72 MYBPC3 MYH6 MYH7 TNNI3 TTN
9 regulation of heart rate GO:0002027 9.7 DMD MYH6 MYH7
10 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.7 MYBPC3 MYH6 MYH7 MYL2 TNNI3 TNNT2
11 regulation of muscle contraction GO:0006937 9.69 TNNI3 TNNT2 TPM1
12 heart contraction GO:0060047 9.67 ACTC1 MYL2 TNNI3
13 cardiac myofibril assembly GO:0055003 9.65 ACTC1 MYL2 TTN
14 negative regulation of ATPase activity GO:0032780 9.63 PLN TNNI3 TNNT2
15 muscle cell cellular homeostasis GO:0046716 9.61 DMD LAMP2
16 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.61 DMD PLN
17 muscle fiber development GO:0048747 9.6 DMD MYL2
18 cardiac muscle tissue morphogenesis GO:0055008 9.59 ACTC1 TTN
19 adult heart development GO:0007512 9.58 MYH6 MYH7
20 cardiac muscle fiber development GO:0048739 9.58 MYH6 TTN
21 regulation of striated muscle contraction GO:0006942 9.57 MYBPC3 MYL2
22 skeletal muscle thin filament assembly GO:0030240 9.56 ACTC1 TTN
23 cardiac muscle contraction GO:0060048 9.36 ACTC1 DMD MYBPC3 MYH6 MYH7 MYL2

Molecular functions related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 ACTN2 DES MYBPC3 PLN TTN TTR
2 structural constituent of cytoskeleton GO:0005200 9.7 DES DMD TPM1
3 actin filament binding GO:0051015 9.63 ACTN2 MYBPC3 TNNI3 TPM1 TTN VCL
4 cytoskeletal protein binding GO:0008092 9.61 ACTN2 DES TPM1
5 actin binding GO:0003779 9.61 ACTN2 DMD MYBPC3 MYH6 MYH7 TNNI3
6 microfilament motor activity GO:0000146 9.55 MYH6 MYH7
7 muscle alpha-actinin binding GO:0051371 9.54 MYBPC3 TTN
8 titin binding GO:0031432 9.51 ACTN2 MYBPC3
9 structural molecule activity conferring elasticity GO:0097493 9.49 MYBPC3 TTN
10 actin-dependent ATPase activity GO:0030898 9.48 MYH6 MYH7
11 dystroglycan binding GO:0002162 9.46 DMD VCL
12 myosin binding GO:0017022 9.43 ACTC1 DMD MYBPC3
13 myosin heavy chain binding GO:0032036 9.4 MYBPC3 MYL2
14 troponin C binding GO:0030172 9.32 TNNI3 TNNT2
15 structural constituent of muscle GO:0008307 9.1 ACTN2 DMD MYBPC3 MYL2 TPM1 TTN

Sources for Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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