MCID: CRD011
MIFTS: 68

Cardiomyopathy malady

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Neuronal diseases, Ear diseases

Aliases & Classifications for Cardiomyopathy

Aliases & Descriptions for Cardiomyopathy:

Name: Cardiomyopathy 24 29 52 41 3
Cardiomyopathies 69

Classifications:



External Ids:

ICD10 33 I42

Summaries for Cardiomyopathy

MedlinePlus : 41 cardiomyopathy is the name for diseases of the heart muscle. these diseases enlarge your heart muscle or make it thicker and more rigid than normal. in rare cases, scar tissue replaces the muscle tissue. some people live long, healthy lives with cardiomyopathy. some people don't even realize they have it. in others, however, it can make the heart less able to pump blood through the body. this can cause serious complications, including heart failure abnormal heart rhythms heart valve problems sudden cardiac arrest heart attacks, high blood pressure, infections, and other diseases can all cause cardiomyopathy. some types of cardiomyopathy run in families. in many people, however, the cause is unknown. treatment might involve medicines, surgery, other medical procedures, and lifestyle changes. nih: national heart, lung, and blood institute

MalaCards based summary : Cardiomyopathy, also known as cardiomyopathies, is related to emery-dreifuss muscular dystrophy, dominant type and familial partial lipodystrophy, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Cardiomyopathy is LMNA (Lamin A/C), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and Vascular smooth muscle contraction. The drugs Verapamil and Spironolactone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and muscle

CDC : 3 Cardiomyopathy Awareness Month is observed in September! For more information, visit http://www.childrenscardiomyopathy.org/site/awareness-month-2015.php.

Wikipedia : 71 Cardiomyopathy is a group of diseases that affect the heart muscle. Early on there may be few or no... more...

Related Diseases for Cardiomyopathy

Diseases in the Cardiomyopathy family:

Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1a
Cardiomyopathy, Dilated, 1v Cardiomyopathy, Dilated, 1d
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 1z Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1gg Cardiomyopathy, Dilated, 1l
Cardiomyopathy, Dilated, 1k Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1p Cardiomyopathy, Dilated, 1j
Cardiomyopathy, Dilated, 2b Cardiomyopathy, Dilated, 1q
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1t Cardiomyopathy, Dilated, 1ee
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1r
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff Cardiomyopathy, Dilated, 3b
Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Dilated Cardiomyopathy 1c Dilated Cardiomyopathy 1aa
Dilated Cardiomyopathy 1b Lmna-Related Dilated Cardiomyopathy
Cardiomyopathy Due to Anthracyclines Mypn-Related Cardiomyopathy
Abcc9-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Actn2-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Cryab-Related Dilated Cardiomyopathy
Csrp3-Related Dilated Cardiomyopathy Des-Related Dilated Cardiomyopathy
Dsg2-Related Dilated Cardiomyopathy Eya4-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Gatad1-Related Dilated Cardiomyopathy
Lama4-Related Dilated Cardiomyopathy Ldb3-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
Myh7-Related Dilated Cardiomyopathy Nexn-Related Dilated Cardiomyopathy
Pln-Related Dilated Cardiomyopathy Prdm16-Related Dilated Cardiomyopathy
Psen1-Related Dilated Cardiomyopathy Psen2-Related Dilated Cardiomyopathy
Rbm20-Related Dilated Cardiomyopathy Scn5a-Related Dilated Cardiomyopathy
Sdha-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Taz-Related Dilated Cardiomyopathy Tcap-Related Dilated Cardiomyopathy
Tmpo-Related Dilated Cardiomyopathy Tnnc1-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Tnnt2-Related Dilated Cardiomyopathy
Tpm1-Related Dilated Cardiomyopathy Ttn-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy

Diseases related to Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)
id Related Disease Score Top Affiliating Genes
1 emery-dreifuss muscular dystrophy, dominant type 30.3 ACTC1 ACTN2 DMD DSG2 LAMP2 LMNA
2 familial partial lipodystrophy 30.0 ACTN2 DMD DSG2 LMNA TTN
3 dilated cardiomyopathy 12.4
4 restrictive cardiomyopathy 12.2
5 cardiomyopathy, familial hypertrophic 12.2
6 infantile histiocytoid cardiomyopathy 12.2
7 peripartum cardiomyopathy 12.1
8 cardiomyopathy, dilated, 1e 12.1
9 alcoholic cardiomyopathy 12.1
10 arrhythmogenic right ventricular cardiomyopathy 12.1
11 cardiomyopathy, dilated, 1kk 12.0
12 cardiomyopathy, dilated, 3b 12.0
13 cardiomyopathy, dilated, 1l 12.0
14 cardiomyopathy, dilated, 1a 12.0
15 cardiomyopathy, dilated, 1x 12.0
16 cardiomyopathy, dilated, 1o 12.0
17 cardiomyopathy, dilated, 1g 12.0
18 cardiomyopathy, dilated, 1p 12.0
19 cardiomyopathy, dilated, 1j 12.0
20 cardiomyopathy, dilated, with woolly hair and keratoderma 11.9
21 cardiomyopathy, dilated, 1ff 11.9
22 cardiomyopathy, dilated, 1w 11.9
23 cardiomyopathy, dilated, 1v 11.9
24 cardiomyopathy, dilated, 1jj 11.9
25 cardiomyopathy, dilated, 1bb 11.9
26 cardiomyopathy, dilated, 1d 11.9
27 cardiomyopathy, dilated, 1u 11.9
28 cardiomyopathy, dilated, 1r 11.9
29 cardiomyopathy, dilated, 1dd 11.9
30 cardiomyopathy, dilated, 1ii 11.9
31 cardiomyopathy, dilated, 1hh 11.9
32 cardiomyopathy, dilated, 1z 11.9
33 cardiomyopathy, dilated, 2b 11.9
34 cardiomyopathy, dilated, 1i 11.9
35 cardiomyopathy, dilated, 1cc 11.9
36 cardiomyopathy, dilated, 1m 11.9
37 cardiomyopathy, dilated, 1ee 11.9
38 cardiomyopathy, dilated, 1gg 11.9
39 cardiomyopathy, dilated, 2a 11.9
40 cardiomyopathy, dilated, 1nn 11.9
41 familial amyloid cardiomyopathy 11.9
42 cardiomyopathy, dilated, 1h 11.9
43 cardiomyopathy, dilated, 1t 11.9
44 dilated cardiomyopathy 1aa 11.9
45 dilated cardiomyopathy 1b 11.9
46 cardiomyopathy, hypertrophic, 8 11.9
47 cardiomyopathy, hypertrophic, 10 11.9
48 dilated cardiomyopathy 1c 11.9
49 cardiomyopathy, dilated, 1q 11.9
50 cardiomyopathy, dilated, 1k 11.9

Comorbidity relations with Cardiomyopathy via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Cardiomyopathy:



Diseases related to Cardiomyopathy

Symptoms & Phenotypes for Cardiomyopathy

UMLS symptoms related to Cardiomyopathy:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Cardiomyopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 LMNA MYBPC3 MYH6 MYH7 MYL2 TNNI3
2 muscle MP:0005369 9.4 MYBPC3 MYH6 MYH7 MYL2 TNNI3 TNNT2

Drugs & Therapeutics for Cardiomyopathy

Drugs for Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 488)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 4 52-53-9 2520
2
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1 1952-01-7, 52-01-7 5833
3
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137862-53-4 60846
4
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
5
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541
6
Amlodipine Approved Phase 4 88150-42-9 2162
7
Carvedilol Approved, Investigational Phase 4,Phase 2 72956-09-3 2585
8
Eplerenone Approved Phase 4,Phase 3,Phase 1 107724-20-9 150310 443872
9
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
10
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2 142387-99-3, 95635-55-5 56959
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
12
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
13
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
14
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
15
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
16
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
17
Captopril Approved Phase 4,Phase 1 62571-86-2 44093
18
Lisinopril Approved, Investigational Phase 4 83915-83-7 5362119
19
Ramipril Approved Phase 4 87333-19-5 5362129
20
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
21
Trandolapril Approved Phase 4 87679-37-6 5484727
22
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
23
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
24
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3 37350-58-6, 51384-51-1 4171
25
Doxazosin Approved Phase 4 74191-85-8 3157
26
Deferoxamine Approved, Investigational Phase 4 70-51-9 2973
27
Cilostazol Approved Phase 4 73963-72-1 2754
28
Allopurinol Approved Phase 4,Phase 1,Phase 2 315-30-0 2094
29
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
30
Dobutamine Approved Phase 4,Phase 3,Phase 1,Phase 2 34368-04-2 36811
31
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
32
Sevoflurane Approved, Vet_approved Phase 4,Phase 1,Phase 2 28523-86-6 5206
33
Remifentanil Approved Phase 4 132875-61-7 60815
34
Deferiprone Approved Phase 4 30652-11-0 2972
35
Darbepoetin alfa Approved, Investigational Phase 4,Phase 3 11096-26-7, 209810-58-2
36
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 1
37
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1 54-31-9 3440
38
Chlorthalidone Approved Phase 4 77-36-1 2732
39
Milrinone Approved Phase 4,Phase 1,Phase 2 78415-72-2 4197
40
Selenium Approved, Vet_approved Phase 4,Phase 3 7782-49-2
41
Tadalafil Approved, Investigational Phase 4,Phase 1,Phase 2 171596-29-5 110635
42
Empagliflozin Approved Phase 4,Phase 3 864070-44-0
43
Glimepiride Approved Phase 4 93479-97-1 3476
44
Propafenone Approved Phase 4 54063-53-5 4932
45
Trastuzumab Approved, Investigational Phase 4 180288-69-1 9903
46
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
47
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2 67-97-0 6221 10883523 5280795
48
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2 50-14-6 5280793
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-30-3 6037
50
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175

Interventional clinical trials:

(show top 50) (show all 943)
id Name Status NCT ID Phase
1 CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone Unknown status NCT00401856 Phase 4
2 Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy Unknown status NCT00348530 Phase 4
3 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Unknown status NCT01293903 Phase 4
4 Identification of Carnitine-Responsive Cardiomyopathy Unknown status NCT01904396 Phase 4
5 Therapy With Verapamil or Carvedilol in Chronic Heart Failure Unknown status NCT00374465 Phase 4
6 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4
7 Danish ICD Study in Patients With Dilated Cardiomyopathy Unknown status NCT00542945 Phase 4
8 Revascularization in Heart Failure Trial – REHEAT 2 Unknown status NCT00388245 Phase 4
9 The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy Unknown status NCT00606775 Phase 4
10 Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary Exercise Capacity Unknown status NCT00326690 Phase 4
11 Evaluation of Efficacy and Safety of Agalsidase Beta in Heterozygous Females for Fabry Disease Unknown status NCT00487630 Phase 4
12 Effects of Spironolactone in Dialysis Unknown status NCT01128101 Phase 4
13 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4
14 Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Unknown status NCT01979965 Phase 4
15 A Strategy of Home Telehealth for Management of Congestive Heart Failure(STARTEL) Unknown status NCT00247000 Phase 4
16 Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy Completed NCT02115581 Phase 4
17 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4
18 Exercise Training in Chagas Cardiomyopathy Completed NCT01006473 Phase 4
19 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4
20 Ranolazine in Ischemic Cardiomyopathy Completed NCT01345188 Phase 4
21 Ranolazine for the Treatment of Chest Pain in HCM Patients Completed NCT01721967 Phase 4
22 Statin Therapy for Ischemic and Nonischemic Cardiomyopathy Completed NCT00701220 Phase 4
23 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4
24 Aspirin Withdrawal in Non-ischaemic Cardiomyopathy Study Completed NCT01534026 Phase 4
25 Chronic, Low Dose Erythropoetin Beta in Ischemic Cardiomyopathy Completed NCT00568542 Phase 4
26 PACMAN - PAcing for CardioMyopathies, a EuropeAN Study Completed NCT00180596 Phase 4
27 Spironolactone Against Anthracycline-induced Cardiomyopathy Completed NCT02053974 Phase 4
28 Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart Completed NCT01798992 Phase 4
29 ACC - Atrial Contribution to CRT Completed NCT00180323 Phase 4
30 Impact of Nesiritide Infusion for Decompensated Heart Failure in the Emergency Department Completed NCT00559338 Phase 4
31 Clinical Evaluation on Advanced Resynchronization Completed NCT00658203 Phase 4
32 123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging on a Small Field of View-High Efficiency Cardiac SPECT System Completed NCT01868841 Phase 4
33 Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure Completed NCT01261065 Phase 4
34 Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major Completed NCT00800761 Phase 4
35 Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Completed NCT00391846 Phase 4
36 Myocardial Glucose Uptake (MGU) in Patients With Chronic Kidney Disease Completed NCT00883415 Phase 4
37 Spanish Atrial Fibrillation And Resynchronization Study Completed NCT01181414 Phase 4
38 Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients Completed NCT00477789 Phase 4
39 Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients Completed NCT00128024 Phase 4
40 Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes Completed NCT00692237 Phase 4
41 Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS) Completed NCT00371891 Phase 4
42 Statin Therapy in Heart Failure: Potential Mechanisms of Benefit Completed NCT00233480 Phase 4
43 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
44 Prevention of CHOP-induced Chronic Cardiotoxicity Completed NCT00162955 Phase 4
45 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4
46 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
47 Myocardial Protection and Anesthetic Agents Completed NCT02405689 Phase 4
48 Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit) Completed NCT01601795 Phase 4
49 ACCEL-LOADING-ACS Study Completed NCT01354808 Phase 4
50 Effects of Levosimendan and Milrinone on Left and Right Ventricular Function in Septic Cardiomyopathy Recruiting NCT02640846 Phase 4

Search NIH Clinical Center for Cardiomyopathy

Genetic Tests for Cardiomyopathy

Genetic tests related to Cardiomyopathy:

id Genetic test Affiliating Genes
1 Cardiomyopathy 29 24

Anatomical Context for Cardiomyopathy

MalaCards organs/tissues related to Cardiomyopathy:

39
Heart, Testes, Brain, Lung, Liver, Endothelial, Skeletal Muscle

Publications for Cardiomyopathy

Articles related to Cardiomyopathy:

(show top 50) (show all 6692)
id Title Authors Year
1
Dilated Cardiomyopathy and Hydroxychloroquine-induced Phospholipidosis: From Curvilinear Bodies to Clinical Suspicion. ( 28528883 )
2017
2
Renin-angiotensin system gene polymorphisms as potential modifiers of hypertrophic and dilated cardiomyopathy phenotypes. ( 28120210 )
2017
3
Re: Myocardial Recovery in Peripartum Cardiomyopathy after Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28114195 )
2017
4
Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice. ( 28090637 )
2017
5
Genotype-specific pathogenic effects in human dilated cardiomyopathy. ( 28436080 )
2017
6
A Case of Anagrelide-Induced Nonischemic Cardiomyopathy in a Patient With Essential Thrombocythemia. ( 28343445 )
2017
7
Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy. ( 28065693 )
2017
8
Barth Syndrome with Late-Onset Cardiomyopathy: A Missed Opportunity for Diagnosis. ( 28108107 )
2017
9
The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy. ( 28430627 )
2017
10
MY APPROACH to the evaluation of restrictive cardiomyopathy. ( 27989285 )
2017
11
Identification of established arrhythmogenic right ventricular cardiomyopathy mutation in a patient with the contrasting phenotype of hypertrophic cardiomyopathy. ( 28253841 )
2017
12
Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11. ( 28050600 )
2017
13
Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes. ( 28082330 )
2017
14
Autosomal Recessive Nonsyndromic Arrhythmogenic Right Ventricular Cardiomyopathy without Cutaneous Involvements: A Novel Mutation. ( 28523642 )
2017
15
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. ( 28081170 )
2017
16
Late presentation of hypertrophic cardiomyopathy with apical aneurysm. ( 28052918 )
2017
17
Dilated Cardiomyopathy in a 2-Year-Old Infant. ( 28062634 )
2017
18
Characterization of the arrhythmogenic substrate in patients with arrhythmogenic right ventricular cardiomyopathy undergoing ventricular tachycardia ablation. ( 28371837 )
2017
19
Early recurrence of Tako-Tsubo cardiomyopathy in an elderly woman with amyotrophic lateral sclerosis: different triggers inducing different apical ballooning patterns. ( 28079765 )
2017
20
In-depth proteomic profiling of left ventricular tissues in human end-stage dilated cardiomyopathy. ( 28427148 )
2017
21
Myocardial deformation in iron overload cardiomyopathy: speckle tracking imaging in a beta-thalassemia major population. ( 28456904 )
2017
22
Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations. ( 28296734 )
2017
23
AlstrAPm Syndrome: A Rare Cause of Cardiomyopathy. ( 28285938 )
2017
24
Primary Prevention of Sudden Arrhythmic Death in Dilated Cardiomyopathy: Current Guidelines and Risk Stratification. ( 28034375 )
2017
25
Truncating mutations on myofibrillar myopathies causing genes as prevalent molecular explanations on patients with dilated cardiomyopathy. ( 28436997 )
2017
26
Peripartum Cardiomyopathy in Cardiac MRI: A Case Report. ( 27846644 )
2017
27
Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular, and genetic factors. ( 28079110 )
2017
28
Implantable cardioverter-defibrillator therapy among patients with non-ischaemic vs. ischaemic cardiomyopathy for primary prevention of sudden cardiac death. ( 28082419 )
2017
29
Does Body Mass Index Predict Premature Cardiomyopathy Onset for Duchenne Muscular Dystrophy? ( 28084148 )
2017
30
Correction to: "Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy." ( 28087848 )
2017
31
12-month patterns of serum markers of collagen synthesis, transforming growth factor and connective tissue growth factor are similar in new-onset and chronic dilated cardiomyopathy in patients both with and without cardiac fibrosis. ( 28460256 )
2017
32
Myocardial blood flow and left ventricular functional reserve in hypertrophic cardiomyopathy: a (13)NH3 gated PET study. ( 28050630 )
2017
33
Variable clinical course of identical twin neonates with AlstrAPm syndrome presenting coincidentally with dilated cardiomyopathy. ( 28407410 )
2017
34
Combined therapy with beta-blockers and ACE-inhibitors/angiotensin receptor blockers and recurrence of Takotsubo (stress) cardiomyopathy: A meta-regression study. ( 28040283 )
2017
35
Athlete's heart vs. apical hypertrophic cardiomyopathy: look again! ( 28065914 )
2017
36
Arrhythmogenic right ventricular dysplasia/cardiomyopathy. ( 28084951 )
2017
37
Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (I^-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy. ( 28193612 )
2017
38
Electrocardiographic differentiation of idiopathic right ventricular outflow tract ectopy from early arrhythmogenic right ventricular cardiomyopathy. ( 28431055 )
2017
39
Electronic health record phenotype in subjects with genetic variants associated with arrhythmogenic right ventricular cardiomyopathy: a study of 30,716 subjects with exome sequencing. ( 28471438 )
2017
40
Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact. ( 28041712 )
2017
41
Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion. ( 28431057 )
2017
42
Sokolow-Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy. ( 28471539 )
2017
43
The Hemodynamic Effects and Safety of Repetitive Levosimendan Infusions on Children With Dilated Cardiomyopathy. ( 28033083 )
2017
44
Surgical Treatment of Arrhythmogenic Right Ventricular Cardiomyopathy with Absent Pulmonary Valve. ( 28524842 )
2017
45
Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. ( 27922664 )
2017
46
Should epsilon wave be considered as a major diagnostic criterion in arrhythmogenic right ventricular cardiomyopathy? ( 28326523 )
2017
47
Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome. ( 28329361 )
2017
48
Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients. ( 28356264 )
2017
49
Titin Truncating Variants in Dilated Cardiomyopathy - Prevalence and Genotype-Phenotype Correlations. ( 28045975 )
2017
50
Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy. ( 28256248 )
2017

Variations for Cardiomyopathy

ClinVar genetic disease variations for Cardiomyopathy:

6 (show top 50) (show all 51)
id Gene Variation Type Significance SNP ID Assembly Location
1 MYBPC3 NM_000256.3(MYBPC3) duplication Pathogenic/Likely pathogenic rs193922384 GRCh38 Chromosome 11, 47332127: 47332144
2 TNNT2 NM_001001430.2(TNNT2): c.421C> T (p.Arg141Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315379 GRCh37 Chromosome 1, 201333464: 201333464
3 TNNI3 NM_000363.4(TNNI3): c.575G> A (p.Arg192His) single nucleotide variant Pathogenic/Likely pathogenic rs104894729 GRCh37 Chromosome 19, 55663260: 55663260
4 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 GRCh37 Chromosome 18, 29178618: 29178618
5 MYBPC3 NM_000256.3(MYBPC3): c.1168delC (p.His390Metfs) deletion Pathogenic rs397515889 GRCh37 Chromosome 11, 47365098: 47365098
6 MYBPC3 NM_000256.3(MYBPC3): c.2311dupG (p.Val771Glyfs) duplication Pathogenic rs397515960 GRCh37 Chromosome 11, 47359343: 47359343
7 MYBPC3 NM_000256.3(MYBPC3): c.2534_2538delGCGTC (p.Arg845Leufs) deletion Pathogenic rs397515973 GRCh37 Chromosome 11, 47359006: 47359010
8 MYBPC3 NM_000256.3(MYBPC3): c.2610dupC (p.Ser871Glnfs) duplication Pathogenic rs397515979 GRCh37 Chromosome 11, 47357555: 47357555
9 MYBPC3 NM_000256.3(MYBPC3): c.3476_3479dupTTAT (p.Pro1161Tyrfs) duplication Pathogenic rs397516019 GRCh37 Chromosome 11, 47354376: 47354379
10 MYBPC3 NM_000256.3(MYBPC3): c.913_914delTT (p.Phe305Profs) deletion Pathogenic/Likely pathogenic rs397516080 GRCh37 Chromosome 11, 47368190: 47368191
11 MYH7 NM_000257.3(MYH7): c.1106G> A (p.Arg369Gln) single nucleotide variant Likely pathogenic rs397516089 GRCh37 Chromosome 14, 23899016: 23899016
12 MYH7 NM_000257.3(MYH7): c.5401G> A (p.Glu1801Lys) single nucleotide variant Likely pathogenic rs397516248 GRCh37 Chromosome 14, 23884362: 23884362
13 PLN NM_002667.4(PLN): c.40_42delAGA (p.Arg14del) deletion Pathogenic rs397516784 GRCh37 Chromosome 6, 118880124: 118880126
14 LMNA NM_170707.3(LMNA): c.1304_1307dupGCAC (p.Ser437Hisfs) duplication Pathogenic rs267607577 GRCh37 Chromosome 1, 156106151: 156106154
15 MYH7 NM_000257.3(MYH7): c.1573G> A (p.Glu525Lys) single nucleotide variant Pathogenic/Likely pathogenic rs606231324 GRCh37 Chromosome 14, 23897714: 23897714
16 ACTN2 NM_001103.3(ACTN2): c.355G> A (p.Ala119Thr) single nucleotide variant Pathogenic rs727502886 GRCh37 Chromosome 1, 236882307: 236882307
17 DSP NM_004415.3(DSP): c.939+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs727504443 GRCh37 Chromosome 6, 7565754: 7565754
18 DSP NM_004415.3(DSP): c.3630T> A (p.Tyr1210Ter) single nucleotide variant Pathogenic/Likely pathogenic rs727503001 GRCh37 Chromosome 6, 7580053: 7580053
19 MYBPC3 NM_000256.3(MYBPC3): c.2875_2876delAC (p.Thr959Glyfs) deletion Pathogenic rs727503182 GRCh38 Chromosome 11, 47335071: 47335072
20 MYBPC3 NM_000256.3(MYBPC3): c.2556delC (p.Ile852Metfs) deletion Pathogenic rs727503186 GRCh37 Chromosome 11, 47358988: 47358988
21 MYBPC3 NM_000256.3(MYBPC3): c.1351+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs727503204 GRCh37 Chromosome 11, 47364571: 47364571
22 MYBPC3 NM_000256.3(MYBPC3): c.3776delA (p.Gln1259Argfs) deletion Pathogenic/Likely pathogenic rs727503166 GRCh38 Chromosome 11, 47332110: 47332110
23 MYH7 NM_000257.3(MYH7): c.4498C> T (p.Arg1500Trp) single nucleotide variant Pathogenic/Likely pathogenic rs45544633 GRCh37 Chromosome 14, 23886383: 23886383
24 MYH7 NM_000257.3(MYH7): c.2302G> A (p.Gly768Arg) single nucleotide variant Pathogenic/Likely pathogenic rs727503260 GRCh38 Chromosome 14, 23425403: 23425403
25 MYH7 NM_000257.3(MYH7): c.1157A> G (p.Tyr386Cys) single nucleotide variant Likely pathogenic rs727503269 GRCh37 Chromosome 14, 23898538: 23898538
26 TNNI3 NM_000363.4(TNNI3): c.509G> A (p.Arg170Gln) single nucleotide variant Pathogenic/Likely pathogenic rs727503503 GRCh37 Chromosome 19, 55665438: 55665438
27 MYBPC3 NM_000256.3(MYBPC3): c.1038_1042dupCGGCA (p.Met348Thrfs) duplication Pathogenic rs730880336 GRCh38 Chromosome 11, 47346255: 47346259
28 TNNT2 NM_001001430.2(TNNT2): c.814dupC (p.Gln272Profs) duplication Pathogenic rs730881119 GRCh38 Chromosome 1, 201359630: 201359630
29 MYBPC3 NM_000256.3(MYBPC3): c.3467dupA (p.Pro1157Alafs) duplication Pathogenic rs730880720 GRCh38 Chromosome 11, 47332837: 47332837
30 MYBPC3 NM_000256.3(MYBPC3): c.3472_3481delGTCTTTATCC (p.Val1158Profs) deletion Pathogenic rs730880675 GRCh38 Chromosome 11, 47332823: 47332832
31 MYBPC3 NM_000256.3(MYBPC3): c.3327delC (p.Met1110Trpfs) deletion Pathogenic rs730880719 GRCh37 Chromosome 11, 47354748: 47354748
32 MYBPC3 NM_000256.3(MYBPC3): c.3302_3303delCA (p.Thr1101Serfs) deletion Pathogenic rs730880671 GRCh38 Chromosome 11, 47333221: 47333222
33 MYBPC3 NM_000256.3(MYBPC3): c.3182_3190+4del deletion Pathogenic rs730880718 GRCh37 Chromosome 11, 47355104: 47355116
34 MYBPC3 NM_000256.3(MYBPC3): c.3079delGinsAA (p.Asp1027Lysfs) indel Pathogenic rs730880666 GRCh37 Chromosome 11, 47355219: 47355219
35 MYBPC3 NM_000256.3(MYBPC3): c.3029_3030delAG (p.Glu1010Glyfs) deletion Pathogenic rs730880665 GRCh37 Chromosome 11, 47355268: 47355269
36 MYBPC3 NM_000256.3(MYBPC3): c.2894_2905+4del deletion Pathogenic rs730880717 GRCh37 Chromosome 11, 47356589: 47356604
37 MYBPC3 NM_000256.3(MYBPC3): c.2604delT (p.Ser871Alafs) deletion Pathogenic rs730880655 GRCh37 Chromosome 11, 47357561: 47357561
38 MYBPC3 NM_000256.3(MYBPC3): c.2543delC (p.Ala848Glyfs) deletion Pathogenic rs730880715 GRCh38 Chromosome 11, 47337450: 47337450
39 MYBPC3 NM_000256.3(MYBPC3): c.2382delG (p.Pro795Leufs) deletion Pathogenic rs730880714 GRCh38 Chromosome 11, 47337721: 47337721
40 MYBPC3 NM_000256.3(MYBPC3): c.1838dupA (p.Asp613Glufs) duplication Pathogenic/Likely pathogenic rs730880649 GRCh38 Chromosome 11, 47341197: 47341197
41 MYBPC3 NM_000256.3(MYBPC3): c.1806delC (p.Ile603Leufs) deletion Pathogenic rs730880648 GRCh37 Chromosome 11, 47362780: 47362780
42 MYBPC3 NM_000256.3(MYBPC3): c.1358dupC (p.Val454Cysfs) duplication Pathogenic/Likely pathogenic rs730880711 GRCh38 Chromosome 11, 47342929: 47342929
43 MYBPC3 NM_000256.3(MYBPC3): c.1156_1171dup16 (p.Asp391Glyfs) duplication Pathogenic rs730880689 GRCh38 Chromosome 11, 47343544: 47343559
44 MYBPC3 NM_000256.3(MYBPC3): c.1120dupC (p.Gln374Profs) duplication Pathogenic rs730880688 GRCh37 Chromosome 11, 47365146: 47365146
45 MYBPC3 NM_000256.3(MYBPC3): c.722dupT (p.Ser242Valfs) duplication Pathogenic rs730880683 GRCh37 Chromosome 11, 47370025: 47370025
46 MYBPC3 NM_000256.3(MYBPC3): c.923_924insAACT (p.Arg309Thrfs) insertion Pathogenic rs730880678 GRCh38 Chromosome 11, 47346629: 47346630
47 LAMP2 NM_002294.2(LAMP2): c.588_589insCAACA (p.Val197Glnfs) insertion Pathogenic rs730880492 GRCh37 Chromosome X, 119581848: 119581849
48 MYBPC3 NM_000256.3: c.3315delG deletion Pathogenic
49 DSG2 NM_001943.4(DSG2): c.86_87delTAinsATTCTATTGTTGTGCTATTGTTAT (p.Leu29Tyrfs) indel Pathogenic rs794728100 GRCh38 Chromosome 18, 31519807: 31519808
50 DSG2 NM_001943.4(DSG2): c.464_465insT (p.Glu156Argfs) insertion Pathogenic rs794728091 GRCh38 Chromosome 18, 31521184: 31521185

Copy number variations for Cardiomyopathy from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 20789 1 154318992 154376502 Deletion LMNA Cardiomyopathy
2 39890 10 121400871 121427319 Deletion BAG3 Cardiomyopathy
3 139275 2 178000000 180600000 Loss TTN Cardiomyopathy
4 140112 2 191900000 197400000 Loss HSP40 Cardiomyopathy
5 262125 X 31047265 33267647 Deletion DMD Cardiomyopathy

Expression for Cardiomyopathy

Search GEO for disease gene expression data for Cardiomyopathy.

Pathways for Cardiomyopathy

Pathways related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 ACTC1 MYH6 MYH7 MYL2 MYL3 VCL
2
Show member pathways
12.83 ACTC1 MYH6 MYH7 MYL2 MYL3 PLN
3
Show member pathways
12.77 ACTN2 MYH6 MYH7 MYL2 MYL3 VCL
4
Show member pathways
12.7 ACTN2 DMD MYBPC3 MYH6 MYL2 MYL3
5
Show member pathways
12.5 ACTC1 ACTN2 MYH6 MYH7 MYL2 MYL3
6 12.39 ACTC1 LMNA TNNI3 TNNT2 TPM1 VCL
7
Show member pathways
12.37 ACTC1 DMD LMNA MYBPC3 MYH6 MYH7
8
Show member pathways
12.3 ACTN2 DMD DSG2 LMNA VCL
9
Show member pathways
12.26 MYH6 MYH7 MYL2 MYL3 VCL
10
Show member pathways
12.2 ACTN2 MYH6 MYH7 MYL2 MYL3
11 11.71 MYL3 TNNI3 TNNT2
12 11.59 ACTC1 ACTN2 DMD MYBPC3 MYH6 MYL2
13 11.49 MYH6 MYH7 PRKAG2
14 11.49 ACTC1 MYH6 MYL2 TNNI3 TNNT2
15 11.17 ACTC1 MYH6 MYH7 MYL2 MYL3 TNNC1

GO Terms for Cardiomyopathy

Cellular components related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 filopodium GO:0030175 9.73 ACTC1 ACTN2 DMD
2 myosin complex GO:0016459 9.73 MYH6 MYH7 MYL2 MYL3
3 Z disc GO:0030018 9.73 ACTN2 DMD MYBPC3 MYH6 MYH7 TTN
4 actin filament GO:0005884 9.72 ACTC1 ACTN2 TPM1
5 stress fiber GO:0001725 9.71 MYH6 MYH7 TPM1
6 I band GO:0031674 9.69 ACTC1 MYL3 TTN
7 myosin filament GO:0032982 9.67 MYBPC3 MYH6 MYH7
8 muscle myosin complex GO:0005859 9.67 MYH6 MYH7 MYL3 TTN
9 A band GO:0031672 9.65 MYBPC3 MYL2 MYL3
10 costamere GO:0043034 9.58 DMD VCL
11 troponin complex GO:0005861 9.58 TNNC1 TNNI3 TNNT2
12 contractile fiber GO:0043292 9.57 TNNC1 TNNI3
13 cell-substrate junction GO:0030055 9.52 DMD VCL
14 cardiac Troponin complex GO:1990584 9.5 TNNC1 TNNI3 TNNT2
15 myofibril GO:0030016 9.5 DMD MYH6 MYH7 MYL2 TNNI3 TNNT2
16 cardiac myofibril GO:0097512 9.46 MYBPC3 MYL2 TNNI3 TNNT2
17 sarcomere GO:0030017 9.32 ACTC1 ACTN2 MYBPC3 MYH6 MYH7 MYL2
18 cytosol GO:0005829 10.33 ACTC1 ACTN2 DMD LMNA MYBPC3 MYH6

Biological processes related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.97 ACTC1 ACTN2 DMD MYBPC3 MYH6 MYH7
2 platelet degranulation GO:0002576 9.88 ACTN2 LAMP2 TTN VCL
3 sarcomere organization GO:0045214 9.8 ACTN2 MYBPC3 MYH6 TPM1 TTN
4 muscle contraction GO:0006936 9.8 ACTN2 MYH6 MYH7 TNNT2 TPM1 TTN
5 positive regulation of ATPase activity GO:0032781 9.78 MYBPC3 MYL3 TNNT2 TPM1
6 striated muscle contraction GO:0006941 9.77 MYBPC3 MYH6 MYH7 TNNI3 TTN
7 regulation of heart contraction GO:0008016 9.76 MYH6 PLN TNNT2 TPM1
8 regulation of heart rate GO:0002027 9.74 DMD MYH6 MYH7
9 regulation of muscle contraction GO:0006937 9.73 TNNC1 TNNI3 TNNT2 TPM1
10 cardiac muscle contraction GO:0060048 9.73 ACTC1 DMD MYBPC3 MYH6 MYH7 MYL2
11 skeletal muscle contraction GO:0003009 9.72 MYH7 TNNC1 TNNI3
12 regulation of the force of heart contraction GO:0002026 9.72 MYH6 MYH7 MYL2 MYL3 PLN
13 heart contraction GO:0060047 9.71 ACTC1 MYL2 TNNI3
14 cardiac myofibril assembly GO:0055003 9.7 ACTC1 MYL2 TTN
15 negative regulation of ATPase activity GO:0032780 9.69 PLN TNNI3 TNNT2
16 regulation of striated muscle contraction GO:0006942 9.67 MYBPC3 MYL2 MYL3
17 muscle cell cellular homeostasis GO:0046716 9.65 DMD LAMP2
18 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.64 DMD PLN
19 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.64 DMD PLN
20 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.63 DMD PLN
21 cardiac muscle hypertrophy in response to stress GO:0014898 9.63 MYH6 MYH7
22 muscle fiber development GO:0048747 9.62 DMD MYL2
23 cardiac muscle tissue morphogenesis GO:0055008 9.62 ACTC1 TTN
24 adult heart development GO:0007512 9.61 MYH6 MYH7
25 cardiac muscle fiber development GO:0048739 9.61 MYH6 TTN
26 regulation of ATPase activity GO:0043462 9.6 MYH6 TNNC1
27 transition between fast and slow fiber GO:0014883 9.59 MYH7 TNNC1
28 skeletal muscle thin filament assembly GO:0030240 9.58 ACTC1 TTN
29 regulation of muscle filament sliding speed GO:0032972 9.56 TNNC1 TNNT2
30 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.28 MYBPC3 MYH6 MYH7 MYL2 MYL3 TNNC1

Molecular functions related to Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.91 ACTN2 DSG2 MYL2 MYL3 TNNC1 TTN
2 motor activity GO:0003774 9.71 MYH6 MYH7 MYL3
3 actin filament binding GO:0051015 9.7 ACTN2 MYBPC3 TNNC1 TNNI3 TPM1 TTN
4 actin binding GO:0003779 9.61 ACTN2 DMD MYBPC3 MYH6 MYH7 TNNI3
5 microfilament motor activity GO:0000146 9.56 MYH6 MYH7
6 muscle alpha-actinin binding GO:0051371 9.55 MYBPC3 TTN
7 titin binding GO:0031432 9.52 ACTN2 MYBPC3
8 structural molecule activity conferring elasticity GO:0097493 9.51 MYBPC3 TTN
9 actin-dependent ATPase activity GO:0030898 9.49 MYH6 MYH7
10 dystroglycan binding GO:0002162 9.48 DMD VCL
11 myosin heavy chain binding GO:0032036 9.46 MYBPC3 MYL2
12 myosin binding GO:0017022 9.43 ACTC1 DMD MYBPC3
13 troponin I binding GO:0031013 9.4 TNNC1 TNNT2
14 troponin T binding GO:0031014 9.37 TNNC1 TNNI3
15 troponin C binding GO:0030172 9.32 TNNI3 TNNT2
16 structural constituent of muscle GO:0008307 9.17 ACTN2 DMD MYBPC3 MYL2 MYL3 TPM1

Sources for Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
49