MCID: CRD144
MIFTS: 40

Cardiovascular Disease Risk Factor ) malady

Categories: Genetic diseases (common), Cardiovascular diseases

Aliases & Classifications for Cardiovascular Disease Risk Factor )

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Aliases & Descriptions for Cardiovascular Disease Risk Factor ):

Name: Cardiovascular Disease Risk Factor ) 24
Hyperlipoproteinemia Type Iii Risk Factor 24
Coronary Artery Disease Risk Factor ) 24
 
Coronary Artery Disease Risk Factor 24
Coronay Artery Disease Risk Factor 24
Cardiovascular Disease Risk Factor 24

Classifications:



Summaries for Cardiovascular Disease Risk Factor )

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MalaCards based summary: Cardiovascular Disease Risk Factor ), also known as hyperlipoproteinemia type iii risk factor, is related to lupus erythematosus and arthritis. An important gene associated with Cardiovascular Disease Risk Factor ) is APOE (Apolipoprotein E), and among its related pathways are Renin secretion and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Affiliated tissues include heart, endothelial and ovary, and related mouse phenotypes are muscle and integument.

Related Diseases for Cardiovascular Disease Risk Factor )

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Diseases related to Cardiovascular Disease Risk Factor ) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.0INS, SELE
2arthritis29.4ACE, APOE
3ischemic heart disease29.3ACE, SERPINE1, VWF
4coronary artery disease29.2ACE, APOB, APOE, INS, SELE, SERPINE1
5obesity28.1ACE, APOB, APOE, INS, PPARA, PPARG
6myocardial infarction26.4ACE, AGT, AGTR1, APOB, APOE, INS
7mthfr thermolabile variant11.1
8shwachman-diamond type metaphyseal dysplasia10.5APOB, SERPINE1
9posterolateral myocardial infarction10.5SELE, SERPINE1
10fetal methyl mercury syndrome10.5APOB, INS
11dysmorphism-pectus carinatum-joint laxity syndrome10.5APOB, APOE
12dermal unilateral segmental cavernous angioma10.4APOB, APOE
13c1s deficiency10.4APOE, INS
14hypercholesterolemia, due to ligand-defective apo b10.4APOB, APOE
15degos 'en cocarde' erythrokeratoderma10.4APOB, APOE
16hemiplegia alterans10.4APOE, INS
17stickler sydrome, type i, nonsyndromic ocular10.4SELE, SERPINE1
18alzheimer disease 19, late onset10.4APOB, APOE
19elejalde disease10.4SELE, SERPINE1
20polyneuropathy10.3APOB, APOE
21gestational choriocarcinoma10.3APOB, INS, SERPINE1
22rubinstein taybi like syndrome10.3APOB, APOE
23antidepressant type abuse10.3INS, PPARG
24chromophobe adenoma10.3SELE, SERPINE1
25inflamed seborrheic keratosis10.2APOB, APOE, INS
26igg4-related hepatopathy10.2ACE, APOE
27listeria meningitis10.2ACE, VWF
28chondrocalcinosis with early-onset osteoarthritis10.2APOB, APOE, INS
29pontocerebellar hypoplasia10.2APOB, APOE, INS
30peripheral degeneration of cornea10.2APOB, APOE
31respiratory syncytial virus infectious disease10.2ACE, APOE
32artery disease10.2
33chronic diarrhea due to guanylate cyclase 2c overactivity10.2ACE, VWF
34apolipoprotein c-iii deficiency10.1APOB, APOE, PPARA
35deafness, x-linked 510.1INS, PPARA, PPARG
36bladder diverticulum10.1APOB, APOE
37retinal arteries, tortuosity of10.0ACE, APOE
38islet cell tumor10.0ACE, APOB, APOE
39diabetic encephalopathy10.0ACE, APOE, INS
40periampullary adenoma10.0ACE, APOE, INS
41conjunctival disease10.0ACE, APOE, SERPINE1
42immunodeficiency 1910.0APOB, APOE, INS, SERPINE1
43keratoacanthoma10.0APOB, APOE, INS, PPARA
44lung hilum cancer10.0ACE, APOE, SERPINE1
45lagophthalmos9.9ACE, PPARA, PPARG
46hypertrichosis9.9ACE, INS, PPARG
47pediatric ulcerative colitis9.9ACE, AGT
48vipoma9.9ACE, APOE, INS
49broad ligament malignant neoplasm9.9ACE, AGTR1
50atherosclerosis9.9

Graphical network of the top 20 diseases related to Cardiovascular Disease Risk Factor ):



Diseases related to cardiovascular disease risk factor  )

Symptoms & Phenotypes for Cardiovascular Disease Risk Factor )

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MGI Mouse Phenotypes related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5AGT, APOB, APOE, INS, PPARA, PPARG
2MP:00107718.2APOE, INS, PPARA, PPARG, SELE, SERPINE1
3MP:00053918.1APOB, APOE, CHRNA7, INS, PPARG, SELE
4MP:00053898.0ACE, AGT, APOB, APOE, CHRNA7, INS
5MP:00053677.8ACE, AGT, AGTR1, APOE, INS, PPARG
6MP:00053867.5ACE, AGT, AGTR1, APOE, CHRNA7, INS
7MP:00053757.4ACE, AGT, AGTR1, APOE, INS, PPARA
8MP:00036317.2AGT, AGTR1, APOB, APOE, CHRNA7, INS
9MP:00053847.0APOB, APOE, CHRNA7, INS, PPARA, PPARG
10MP:00053976.8ACE, AGTR1, APOE, CHRNA7, INS, PPARG
11MP:00053706.4ACE, AGT, APOB, APOE, CHRNA7, INS
12MP:00053856.0ACE, AGT, AGTR1, APOB, APOE, INS
13MP:00053785.9ACE, AGT, AGTR1, APOB, APOE, CHRNA7
14MP:00053875.5ACE, AGT, AGTR1, APOB, APOE, CHRNA7
15MP:00107685.4ACE, AGT, AGTR1, APOB, APOE, CHRNA7
16MP:00053765.2ACE, AGT, AGTR1, APOB, APOE, CHRNA7

Drugs & Therapeutics for Cardiovascular Disease Risk Factor )

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Cardiovascular Disease Risk Factor )

Genetic Tests for Cardiovascular Disease Risk Factor )

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Genetic tests related to Cardiovascular Disease Risk Factor ):

id Genetic test Affiliating Genes
1 Cardiovascular Disease Risk Factor (angiotensin Converting Enzyme (ace))24 ACE
2 Cardiovascular Disease Risk Factor (angiotensin Ii Receptor, Type 1)24 AGTR1
3 Cardiovascular Disease Risk Factor (angiotensinogen)24 AGT
4 Cardiovascular Disease Risk Factor (apolipoprotein E)24 APOE
5 Cardiovascular Disease Risk Factor (carotid Intimal Medial Thickness 1)24 PPARG

Anatomical Context for Cardiovascular Disease Risk Factor )

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MalaCards organs/tissues related to Cardiovascular Disease Risk Factor ):

36
Heart, Endothelial, Ovary, Kidney, Spinal cord

Publications for Cardiovascular Disease Risk Factor )

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Articles related to Cardiovascular Disease Risk Factor ):

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Multicenter Study of Temporal Trends in the Achievement of Atherosclerotic Cardiovascular Disease Risk Factor Goals During Cardiac Rehabilitation. (27798509)
2017
2
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study. (27166203)
2016
3
Objectively Measured Aerobic and Resistance Exercise and Cardiovascular Disease Risk Factor Response: 2164 Board #316 June 2, 3: 30 PM - 5: 00 PM. (27360989)
2016
4
Association Between Cardiovascular Disease Risk Factors and Rotator Cuff Tendinopathy: Cross-Sectional Study. (28002354)
2016
5
Trends in Nonlipid Cardiovascular Disease Risk Factor Management in the Women's Interagency HIV Study and Association with Adherence to Antiretroviral Therapy. (27749112)
2016
6
Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. (27209284)
2016
7
Traditional Cardiovascular Disease Risk Factor Management in Rheumatoid Arthritis Compared to Matched Nonrheumatoid Arthritis in a US Managed Care Setting. (26414069)
2016
8
Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study. (25906186)
2015
9
Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides. (25672297)
2015
10
Cardiovascular disease risk factor profiles of 263,356 older Australians according to region of birth and acculturation, with a focus on migrants born in Asia. (25695771)
2015
11
Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross-Sectional Study. (26364955)
2015
12
Outcomes of cardiovascular disease risk factor screening and referrals in a family planning clinic. (25517351)
2015
13
Cardiovascular disease risk factor clustering among rural adult population in West Bengal, India. (26008793)
2015
14
Clinical Variability in Cardiovascular Disease Risk Factor Screening and Management in Adolescent and Young Adult Women with Polycystic Ovary Syndrome. (26081478)
2015
15
When gout goes to the heart: does gout equal a cardiovascular disease risk factor? (25603830)
2015
16
HIV infection, cardiovascular disease risk factor profile, and risk for acute myocardial infarction. (25588033)
2015
17
Heart matters: Gender and racial differences cardiovascular disease risk factor control among veterans. (25213741)
2014
18
The associations between polymorphisms in the CD36 gene, fat oxidation and cardiovascular disease risk factors in a young adult Australian population: a pilot study. (25277110)
2014
19
Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. (24716628)
2014
20
Cardiovascular Disease Risk Factor Profiling of Group C Employees in JIPMER, Puducherry. (25374865)
2014
21
Physician cardiovascular disease risk factor management: practice analysis in Japan versus the USA. (23735635)
2013
22
Associations of Cardiovascular Disease Risk Factors and Calcified Atherosclerosis With Aortoiliac Bifurcation Position: The Multiethnic Study of Atherosclerosis. (24375634)
2013
23
The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. (23212717)
2013
24
A comparison of the Slaughter skinfold-thickness equations and BMI in predicting body fatness and cardiovascular disease risk factor levels in children. (24153344)
2013
25
Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets. (24039358)
2013
26
Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial. (23187956)
2013
27
Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002-2012 literature review. (24219205)
2013
28
Classical cardiovascular disease risk factors associate with vascular function and morphology in rheumatoid arthritis: a six-year prospective study. (24289091)
2013
29
Dose-response association of uncontrolled blood pressure and cardiovascular disease risk factors with hyperuricemia and gout. (23460805)
2013
30
Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study. (23340887)
2013
31
Managing tobacco use: the neglected cardiovascular disease risk factor. (24014389)
2013
32
A review of family history of cardiovascular disease: risk factor and research tool. (22607505)
2012
33
Absence of cardiovascular disease risk factors in restless legs syndrome. (21718253)
2012
34
Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. (21719451)
2012
35
Immigration disparities in cardiovascular disease risk factor awareness. (22210443)
2012
36
Cardiovascular disease risk factor patterns and their implications for intervention strategies in Vietnam. (22500217)
2012
37
Social determinants of cardiovascular disease risk factor presence among rural and urban Black and White men. (22902779)
2012
38
Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia. (22322083)
2012
39
Is cardiorespiratory fitness a unique cardiovascular disease risk factor? (21903066)
2011
40
Physician cardiovascular disease risk factor management: practices in France vs the United States. (21214716)
2011
41
Cardiovascular disease risk factor clustering among African American adults. (21749014)
2011
42
Cardiovascular disease risk factors: prevalence and management in adult hemophilia patients. (21451396)
2011
43
Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study. (22034506)
2011
44
A cardiovascular disease risk factor screening program designed to reach rural residents of Maine, USA. (21834601)
2011
45
A comparative analysis of the cardiovascular disease risk factor profiles of Pacific peoples and Europeans living in New Zealand assessed in routine primary care: PREDICT CVD-11. (20186243)
2010
46
Physicians' perceptions of barriers to cardiovascular disease risk factor control among patients with diabetes: results from the translating research into action for diabetes (TRIAD) study. (20207927)
2010
47
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (20884846)
2010
48
Differences in cardiovascular disease risk factor management in primary care by sex of physician and patient. (20065275)
2010
49
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (20838585)
2010
50
Job demand and cardiovascular disease risk factor in white-collar workers. (20160403)
2010

Variations for Cardiovascular Disease Risk Factor )

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Expression for genes affiliated with Cardiovascular Disease Risk Factor )

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Search GEO for disease gene expression data for Cardiovascular Disease Risk Factor ).

Pathways for genes affiliated with Cardiovascular Disease Risk Factor )

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GO Terms for genes affiliated with Cardiovascular Disease Risk Factor )

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Cellular components related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:004262710.6APOB, APOE
2endocytic vesicle lumenGO:007168210.6APOB, APOE
3endosome lumenGO:003190410.5APOB, INS
4intermediate-density lipoprotein particleGO:003436310.2APOB, APOE
5low-density lipoprotein particleGO:003436210.1APOB, APOE
6very-low-density lipoprotein particleGO:00343619.8APOB, APOE
7extracellular regionGO:00055768.5ACE, AGT, APOB, APOE, INS, SERPINE1
8extracellular spaceGO:00056158.3ACE, AGT, APOB, APOE, INS, SELE

Biological processes related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:000200310.6ACE, AGT
2fatty acid homeostasisGO:005508910.6APOE, INS
3artery morphogenesisGO:004884410.6APOB, APOE
4cholesterol effluxGO:003334410.5APOB, APOE
5nitric oxide mediated signal transductionGO:000726310.5AGT, APOE
6long-chain fatty acid transportGO:001590910.5APOE, PPARG
7positive regulation of protein tyrosine kinase activityGO:006109810.5ACE, AGT
8lipoprotein biosynthetic processGO:004215810.5APOB, APOE
9lipoprotein catabolic processGO:004215910.5APOB, APOE
10cellular response to prostaglandin stimulusGO:007137910.5APOB, PPARG
11positive regulation of NAD(P)H oxidase activityGO:003386410.5AGT, AGTR1
12positive regulation of lipid biosynthetic processGO:004688910.5APOE, INS
13activation of phospholipase C activityGO:000720210.5AGT, SELE
14positive regulation of nitric-oxide synthase activityGO:005100010.4APOE, INS
15regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.4ACE, AGTR1
16negative regulation of acute inflammatory responseGO:000267410.4INS, PPARG
17regulation of renal output by angiotensinGO:000201910.4ACE, AGT
18lipoprotein transportGO:004295310.4APOB, PPARG
19regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
20regulation of vasodilationGO:004231210.4ACE, AGTR1
21negative regulation of blood coagulationGO:003019510.4APOE, SERPINE1
22renin-angiotensin regulation of aldosterone productionGO:000201810.3AGT, AGTR1
23kidney developmentGO:000182210.3ACE, AGT, AGTR1
24positive regulation of cholesterol esterificationGO:001087310.2AGT, AGTR1, APOE
25negative regulation of cholesterol storageGO:001088710.2PPARA, PPARG
26negative regulation of macrophage derived foam cell differentiationGO:001074510.2PPARA, PPARG
27negative regulation of receptor biosynthetic processGO:001087110.2PPARA, PPARG
28negative regulation of sequestering of triglycerideGO:001089110.2PPARA, PPARG
29positive regulation of fatty acid oxidationGO:004632110.1PPARA, PPARG
30positive regulation of cellular protein metabolic processGO:003227010.1AGT, AGTR1, INS
31triglyceride catabolic processGO:001943310.1APOB, APOE
32regulation of blood pressureGO:000821710.1ACE, AGT, PPARG
33regulation of vasoconstrictionGO:001922910.1ACE, AGT, AGTR1
34positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGT, AGTR1, APOB
35response to immobilization stressGO:003590210.0PPARG, VWF
36positive regulation of inflammatory responseGO:005072910.0AGT, AGTR1, SERPINE1
37vasodilationGO:00423119.9AGT, APOE
38regulation of norepinephrine secretionGO:00140619.9AGT, CHRNA7
39lipoprotein metabolic processGO:00421579.8APOB, APOE, PPARA
40low-density lipoprotein particle remodelingGO:00343749.8AGT, AGTR1, APOB, APOE
41behavioral response to nicotineGO:00350959.8CHRNA7, PPARA
42G-protein coupled receptor signaling pathwayGO:00071869.6AGT, AGTR1, APOE, INS, PPARG
43lipid metabolic processGO:00066299.5APOB, APOE, PPARA, PPARG
44regulation of inflammatory responseGO:00507279.4AGTR1, CHRNA7, SELE
45negative regulation of inflammatory responseGO:00507289.4APOE, CHRNA7, PPARA

Molecular functions related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.7ACE, AGTR1
2cholesterol transporter activityGO:001712710.6APOB, APOE
3low-density lipoprotein particle receptor bindingGO:005075010.6APOB, APOE
4drug bindingGO:000814410.0ACE, PPARA, PPARG
5lipid bindingGO:000828910.0APOB, APOE, PPARA
6protease bindingGO:00020209.9INS, SERPINE1, VWF
7protein bindingGO:00055155.2ACE, AGT, AGTR1, APOB, APOE, CHRNA7

Sources for Cardiovascular Disease Risk Factor )

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet