MCID: CRD144
MIFTS: 42

Cardiovascular Disease Risk Factor ) malady

Categories: Genetic diseases (common), Cardiovascular diseases

Aliases & Classifications for Cardiovascular Disease Risk Factor )

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Aliases & Descriptions for Cardiovascular Disease Risk Factor ):

Name: Cardiovascular Disease Risk Factor ) 23
Hyperlipoproteinemia Type Iii Risk Factor 23
Coronary Artery Disease Risk Factor ) 23
 
Coronary Artery Disease Risk Factor 23
Coronay Artery Disease Risk Factor 23
Cardiovascular Disease Risk Factor 23

Classifications:



Summaries for Cardiovascular Disease Risk Factor )

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MalaCards based summary: Cardiovascular Disease Risk Factor ), also known as hyperlipoproteinemia type iii risk factor, is related to lupus erythematosus and arthritis. An important gene associated with Cardiovascular Disease Risk Factor ) is APOE (Apolipoprotein E), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin secretion. Affiliated tissues include heart, endothelial and ovary, and related mouse phenotypes are muscle and reproductive system.

Related Diseases for Cardiovascular Disease Risk Factor )

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Diseases related to Cardiovascular Disease Risk Factor ) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.3INS, SELE
2arthritis29.6ACE, APOE
3ischemic heart disease29.5ACE, SERPINE1, VWF
4coronary artery disease29.3ACE, APOB, APOE, INS, SELE, SERPINE1
5obesity28.1ACE, APOB, APOE, INS, PPARA, PPARG
6myocardial infarction26.2ACE, AGT, AGTR1, APOB, APOE, INS
7mthfr thermolabile variant11.2
8shwachman-diamond type metaphyseal dysplasia10.6APOB, SERPINE1
9dysmorphism-pectus carinatum-joint laxity syndrome10.6APOB, APOE
10posterolateral myocardial infarction10.5SELE, SERPINE1
11fetal methyl mercury syndrome10.5APOB, INS
12dermal unilateral segmental cavernous angioma10.5APOB, APOE
13hypercholesterolemia, due to ligand-defective apo b10.5APOB, APOE
14degos 'en cocarde' erythrokeratoderma10.5APOB, APOE
15c1s deficiency10.5APOE, INS
16alzheimer disease 19, late onset10.5APOB, APOE
17stickler sydrome, type i, nonsyndromic ocular10.5SELE, SERPINE1
18hemiplegia alterans10.5APOE, INS
19elejalde disease10.4SELE, SERPINE1
20polyneuropathy10.4APOB, APOE
21rubinstein taybi like syndrome10.4APOB, APOE
22gestational choriocarcinoma10.4APOB, INS, SERPINE1
23chromophobe adenoma10.3SELE, SERPINE1
24antidepressant type abuse10.3INS, PPARG
25inflamed seborrheic keratosis10.3APOB, APOE, INS
26igg4-related hepatopathy10.3ACE, APOE
27listeria meningitis10.3ACE, VWF
28chondrocalcinosis with early-onset osteoarthritis10.3APOB, APOE, INS
29artery disease10.3
30pontocerebellar hypoplasia10.3APOB, APOE, INS
31peripheral degeneration of cornea10.3APOB, APOE
32colonic benign neoplasm10.3ACE, APOE
33respiratory syncytial virus infectious disease10.2ACE, APOE
34chronic diarrhea due to guanylate cyclase 2c overactivity10.2ACE, VWF
35apolipoprotein c-iii deficiency10.2APOB, APOE, PPARA
36bladder diverticulum10.1APOB, APOE
37deafness, x-linked 510.1INS, PPARA, PPARG
38islet cell tumor10.1ACE, APOB, APOE
39retinal arteries, tortuosity of10.1ACE, APOE
40diabetic encephalopathy10.0ACE, APOE, INS
41periampullary adenoma10.0ACE, APOE, INS
42atherosclerosis10.0
43conjunctival disease10.0ACE, APOE, SERPINE1
44immunodeficiency 1910.0APOB, APOE, INS, SERPINE1
45lung hilum cancer10.0ACE, APOE, SERPINE1
46keratoacanthoma10.0APOB, APOE, INS, PPARA
47hypertrichosis9.9ACE, INS, PPARG
48pediatric ulcerative colitis9.9ACE, AGT
49lagophthalmos9.9ACE, PPARA, PPARG
50gout9.9

Graphical network of the top 20 diseases related to Cardiovascular Disease Risk Factor ):



Diseases related to cardiovascular disease risk factor  )

Symptoms for Cardiovascular Disease Risk Factor )

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Drugs & Therapeutics for Cardiovascular Disease Risk Factor )

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Cardiovascular Disease Risk Factor )

Genetic Tests for Cardiovascular Disease Risk Factor )

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Genetic tests related to Cardiovascular Disease Risk Factor ):

id Genetic test Affiliating Genes
1 Cardiovascular Disease Risk Factor (angiotensin Converting Enzyme (ace))23 ACE
2 Cardiovascular Disease Risk Factor (angiotensin Ii Receptor, Type 1)23 AGTR1
3 Cardiovascular Disease Risk Factor (angiotensinogen)23 AGT
4 Cardiovascular Disease Risk Factor (apolipoprotein E)23 APOE
5 Cardiovascular Disease Risk Factor (carotid Intimal Medial Thickness 1)23 PPARG

Anatomical Context for Cardiovascular Disease Risk Factor )

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MalaCards organs/tissues related to Cardiovascular Disease Risk Factor ):

34
Heart, Endothelial, Ovary, Kidney, Spinal cord

Animal Models for Cardiovascular Disease Risk Factor ) or affiliated genes

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MGI Mouse Phenotypes related to Cardiovascular Disease Risk Factor ):

39 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3AGT, APOB, APOE, INS, PPARA, PPARG
2MP:00053898.3ACE, AGT, APOB, APOE, CHRNA7, INS
3MP:00107718.2APOE, INS, PPARA, PPARG, SELE, SERPINE1
4MP:00053918.1APOB, APOE, CHRNA7, INS, PPARG, SELE
5MP:00053678.0ACE, AGT, AGTR1, APOE, INS, PPARG
6MP:00053757.5ACE, AGT, AGTR1, APOE, INS, PPARA
7MP:00036317.5AGT, AGTR1, APOB, APOE, CHRNA7, INS
8MP:00053867.2ACE, AGT, AGTR1, APOE, CHRNA7, INS
9MP:00053977.1ACE, AGTR1, APOE, CHRNA7, INS, PPARG
10MP:00053847.0APOB, APOE, CHRNA7, INS, PPARA, PPARG
11MP:00053706.6ACE, AGT, APOB, APOE, CHRNA7, INS
12MP:00053856.0ACE, AGT, AGTR1, APOB, APOE, INS
13MP:00053875.7ACE, AGT, AGTR1, APOB, APOE, CHRNA7
14MP:00053785.7ACE, AGT, AGTR1, APOB, APOE, CHRNA7
15MP:00107685.4ACE, AGT, AGTR1, APOB, APOE, CHRNA7
16MP:00053765.2ACE, AGT, AGTR1, APOB, APOE, CHRNA7

Publications for Cardiovascular Disease Risk Factor )

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Articles related to Cardiovascular Disease Risk Factor ):

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study. (27166203)
2016
2
Objectively Measured Aerobic and Resistance Exercise and Cardiovascular Disease Risk Factor Response: 2164 Board #316 June 2, 3: 30 PM - 5: 00 PM. (27360989)
2016
3
Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study. (25906186)
2015
4
Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides. (25672297)
2015
5
Physician cardiovascular disease risk factor management: practice analysis in Japan versus the USA. (23735635)
2013
6
Associations of Cardiovascular Disease Risk Factors and Calcified Atherosclerosis With Aortoiliac Bifurcation Position: The Multiethnic Study of Atherosclerosis. (24375634)
2013
7
The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. (23212717)
2013
8
A comparison of the Slaughter skinfold-thickness equations and BMI in predicting body fatness and cardiovascular disease risk factor levels in children. (24153344)
2013
9
Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets. (24039358)
2013
10
A review of family history of cardiovascular disease: risk factor and research tool. (22607505)
2012
11
Absence of cardiovascular disease risk factors in restless legs syndrome. (21718253)
2012
12
Is cardiorespiratory fitness a unique cardiovascular disease risk factor? (21903066)
2011
13
Physician cardiovascular disease risk factor management: practices in France vs the United States. (21214716)
2011
14
A comparative analysis of the cardiovascular disease risk factor profiles of Pacific peoples and Europeans living in New Zealand assessed in routine primary care: PREDICT CVD-11. (20186243)
2010
15
Physicians' perceptions of barriers to cardiovascular disease risk factor control among patients with diabetes: results from the translating research into action for diabetes (TRIAD) study. (20207927)
2010
16
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (20884846)
2010
17
Demonstration of community pharmacy and managed care organization collaboration on cardiovascular disease risk factor identification using health risk appraisal. (19289349)
2009
18
Association of BMI and fasting insulin with cardiovascular disease risk factors in seven-year-old Icelandic children. (19731182)
2009
19
The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. (18782342)
2008
20
Cardiovascular disease risk factors and the relationships with physical activity, aerobic fitness, and body fat in adolescents and young adults with myelomeningocele. (18835477)
2008
21
Dyslipidemia and cardiovascular disease risk factor management in HIV-1-infected subjects treated with HAART in the Spanish VACH cohort. (18923695)
2008
22
Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations. (18180784)
2008
23
Genes, fat intake, and cardiovascular disease risk factors in the Quebec Family Study. (17890503)
2007
24
Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention. (16960161)
2006
25
Antithrombin III activity in the elderly--association with cardiovascular disease risk factors]. (16521916)
2005
26
Prevalence of cardiovascular disease risk factor clustering among the adult population of China: results from the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia). (16043645)
2005
27
Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol. (16280425)
2005
28
Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and cardiovascular disease risk factors in young black men and white men: the CARDIA Male Hormone Study. (15466497)
2004
29
Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. (15113713)
2004
30
The influence of an intense cardiovascular disease risk factor modification program. (15010624)
2004
31
Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors. (12966036)
2003
32
Homocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals Study. (12450894)
2002
33
Total and regional fat and serum cardiovascular disease risk factors in lean and obese children and adolescents. (11500523)
2001
34
Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. (11472752)
2001
35
Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk factors: the Quebec Family Study. (11522554)
2001
36
Cardiovascular disease risk factor intervention in low-income women: the North Carolina WISEWOMAN project. (11006062)
2000
37
Clustering of cardiovascular disease risk factors among obese schoolchildren: the Taipei Children Heart Study. (9625086)
1998
38
Prevalence of cardiovascular disease risk-factor clustering among persons aged > or = 45 years--Louisiana, 1991-1995. (9214569)
1997
39
Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors. (9270410)
1997
40
Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. (9351386)
1997
41
The emergence of clinically abnormal levels of cardiovascular disease risk factor variables among young adults: the Bogalusa Heart Study. (8610086)
1995
42
A genetic analysis of cardiovascular disease risk factor clustering in adult female twins. (8314062)
1993
43
Cardiovascular disease risk factor reduction and the occupational health nurse. (2204344)
1990
44
Measurement error and reliability in four pediatric cross-sectional surveys of cardiovascular disease risk factor variables--the Bogalusa Heart Study. (3492509)
1987
45
Characteristics of participants and nonparticipants in a community cardiovascular disease risk factor screening: the Minnesota Heart Health Program. (3453156)
1986
46
Resources for cardiovascular disease risk factor reduction programs in the workplace. (3887256)
1985
47
Tracking of cardiovascular disease risk factor variables in school-age children. (6619260)
1983
48
Cardiovascular disease risk factor variables in children at two successive years--the Bogalusa heart study. (218982)
1979
49
Serum high density lipoprotein and its relationship to cardiovascular disease risk factor variables in children--the Bogalusa heart study. (218070)
1979
50
Dietary studies and the relationship of diet to cardiovascular disease risk factor variables in 10-year-old children--The Bogalusa Heart Study. (623054)
1978

Variations for Cardiovascular Disease Risk Factor )

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Expression for genes affiliated with Cardiovascular Disease Risk Factor )

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Search GEO for disease gene expression data for Cardiovascular Disease Risk Factor ).

Pathways for genes affiliated with Cardiovascular Disease Risk Factor )

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GO Terms for genes affiliated with Cardiovascular Disease Risk Factor )

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Cellular components related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:003436310.5APOB, APOE
2chylomicronGO:004262710.5APOB, APOE
3low-density lipoprotein particleGO:003436210.5APOB, APOE
4very-low-density lipoprotein particleGO:003436110.5APOB, APOE
5endocytic vesicle lumenGO:007168210.5APOB, APOE
6endosome lumenGO:003190410.3APOB, INS
7extracellular spaceGO:00056157.8ACE, AGT, APOB, APOE, INS, SELE
8extracellular regionGO:00055767.5ACE, AGT, APOB, APOE, INS, SERPINE1

Biological processes related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.6ACE, AGTR1
2regulation of renal output by angiotensinGO:000201910.6ACE, AGT
3renin-angiotensin regulation of aldosterone productionGO:000201810.5AGT, AGTR1
4regulation of blood vessel size by renin-angiotensinGO:000203410.5AGT, AGTR1
5regulation of vasodilationGO:004231210.5ACE, AGTR1
6lipoprotein biosynthetic processGO:004215810.5APOB, APOE
7lipoprotein catabolic processGO:004215910.4APOB, APOE
8cholesterol effluxGO:003334410.4APOB, APOE
9cellular response to prostaglandin stimulusGO:007137910.4APOB, PPARG
10long-chain fatty acid transportGO:001590910.4APOE, PPARG
11regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
12artery morphogenesisGO:004884410.3APOB, APOE
13negative regulation of acute inflammatory responseGO:000267410.3INS, PPARG
14angiotensin maturationGO:000200310.3ACE, AGT
15positive regulation of NAD(P)H oxidase activityGO:003386410.3AGT, AGTR1
16activation of phospholipase C activityGO:000720210.3AGT, SELE
17positive regulation of lipid biosynthetic processGO:004688910.3APOE, INS
18negative regulation of blood coagulationGO:003019510.3APOE, SERPINE1
19positive regulation of cholesterol esterificationGO:001087310.2AGT, AGTR1, APOE
20nitric oxide mediated signal transductionGO:000726310.2AGT, APOE
21triglyceride catabolic processGO:001943310.2APOB, APOE
22lipoprotein transportGO:004295310.2APOB, PPARG
23fatty acid homeostasisGO:005508910.1APOE, INS
24regulation of norepinephrine secretionGO:001406110.1AGT, CHRNA7
25positive regulation of protein tyrosine kinase activityGO:006109810.0ACE, AGT
26negative regulation of receptor biosynthetic processGO:001087110.0PPARA, PPARG
27negative regulation of cholesterol storageGO:001088710.0PPARA, PPARG
28positive regulation of nitric-oxide synthase activityGO:005100010.0APOE, INS
29negative regulation of sequestering of triglycerideGO:001089110.0PPARA, PPARG
30response to immobilization stressGO:003590210.0PPARG, VWF
31positive regulation of macrophage derived foam cell differentiationGO:00107449.9AGT, AGTR1, APOB
32positive regulation of cellular protein metabolic processGO:00322709.9AGT, AGTR1, INS
33positive regulation of fatty acid oxidationGO:00463219.9PPARA, PPARG
34vasodilationGO:00423119.9AGT, APOE
35kidney developmentGO:00018229.8ACE, AGT, AGTR1
36positive regulation of inflammatory responseGO:00507299.8AGT, AGTR1, SERPINE1
37regulation of blood pressureGO:00082179.8ACE, AGT, PPARG
38negative regulation of macrophage derived foam cell differentiationGO:00107459.8PPARA, PPARG
39low-density lipoprotein particle remodelingGO:00343749.7AGT, AGTR1, APOB, APOE
40regulation of vasoconstrictionGO:00192299.6ACE, AGT, AGTR1
41behavioral response to nicotineGO:00350959.5CHRNA7, PPARA
42lipoprotein metabolic processGO:00421579.5APOB, APOE, PPARA
43negative regulation of inflammatory responseGO:00507289.3APOE, CHRNA7, PPARA
44regulation of inflammatory responseGO:00507279.2AGTR1, CHRNA7, SELE
45lipid metabolic processGO:00066299.0APOB, APOE, PPARA, PPARG
46G-protein coupled receptor signaling pathwayGO:00071868.8AGT, AGTR1, APOE, INS, PPARG

Molecular functions related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.7ACE, AGTR1
2cholesterol transporter activityGO:001712710.5APOB, APOE
3low-density lipoprotein particle receptor bindingGO:005075010.4APOB, APOE
4lipid bindingGO:00082899.5APOB, APOE, PPARA
5protease bindingGO:00020209.5INS, SERPINE1, VWF
6drug bindingGO:00081449.0ACE, PPARA, PPARG
7protein bindingGO:00055155.2ACE, AGT, AGTR1, APOB, APOE, CHRNA7

Sources for Cardiovascular Disease Risk Factor )

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet