MCID: CRD144
MIFTS: 40

Cardiovascular Disease Risk Factor ) malady

Categories: Genetic diseases (common), Cardiovascular diseases

Aliases & Classifications for Cardiovascular Disease Risk Factor )

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Aliases & Descriptions for Cardiovascular Disease Risk Factor ):

Name: Cardiovascular Disease Risk Factor ) 24
Hyperlipoproteinemia Type Iii Risk Factor 24
Coronary Artery Disease Risk Factor ) 24
 
Coronary Artery Disease Risk Factor 24
Coronay Artery Disease Risk Factor 24
Cardiovascular Disease Risk Factor 24

Classifications:



Summaries for Cardiovascular Disease Risk Factor )

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MalaCards based summary: Cardiovascular Disease Risk Factor ), also known as hyperlipoproteinemia type iii risk factor, is related to myocardial infarction and mthfr thermolabile variant. An important gene associated with Cardiovascular Disease Risk Factor ) is PPARG (Peroxisome Proliferator Activated Receptor Gamma), and among its related pathways are Hypothesized Pathways in Pathogenesis of Cardiovascular Disease and Renin secretion. Affiliated tissues include heart, endothelial and ovary, and related mouse phenotypes are vision/eye and reproductive system.

Related Diseases for Cardiovascular Disease Risk Factor )

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Diseases related to Cardiovascular Disease Risk Factor ) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction28.1ACE, AGT, AGTR1, APOB, APOE, INS
2mthfr thermolabile variant11.1
3zap-70 deficiency10.2APOB, APOE
4keratoconus 410.2APOB, APOE
5coronary artery disease10.2
6artery disease10.2
7x-linked amelogenesis imperfecta hypoplastic/hypomaturation 210.2APOE, VWF
8dentinogenesis imperfecta type 210.2APOB, APOE
9hyperlipoproteinemia type iv10.2APOB, INS, PPARG
10lupus erythematosus panniculitis10.2ACE, APOE
11albinism, oculocutaneous, type v10.2APOB, APOE
12chondrocalcinosis with early-onset osteoarthritis10.2APOB, APOE, INS
13primary pigmented nodular adrenocortical disease10.2APOB, APOE, INS
14bleeding disorder, east texas type10.1APOB, APOE, INS
15c1s deficiency10.1APOE, INS
16iron metabolism disease10.1ACE, APOE
17neonatal diabetes mellitus10.1INS, SELE, VWF
18hypertriglyceridemia10.1APOB, APOE, PPARA
19exostosis10.1APOB, INS, SERPINE1
20alzheimer disease 19, late onset10.1APOB, APOE
21subleukemic leukemia10.1ACE, PPARA, PPARG
22thyroid cancer, anaplastic10.1SELE, SERPINE1, VWF
23limb ischemia10.1ACE, APOE, INS
24pars planitis10.1ACE, APOE
25immune-mediated encephalomyelitis10.1APOE, VWF
26penile cancer, childhood10.0ACE, AGT
27diabetic encephalopathy10.0ACE, APOE, INS
28immunodeficiency 1810.0APOB, APOE, INS, SERPINE1
29listeriosis10.0ACE, VWF
30autosomal recessive congenital ichthyosis10.0INS, PPARA, PPARG, SERPINE1
31secretory diarrhea myopathy and deafness10.0ACE, SERPINE1, VWF
32ischemic optic neuropathy10.0ACE, SERPINE1, VWF
33obesity10.0
34iida kannari syndrome10.0ACE, INS, PPARA, PPARG
35mental retardation, autosomal recessive 2710.0AGT, PPARA, SERPINE1
36optic nerve neoplasm10.0ACE, APOB, APOE, SELE
37malignant hyperthermia susceptibility 110.0ACE, AGT, APOB
38gait apraxia9.9ACE, APOB, APOE, SERPINE1
39narcolepsy 69.9AGT, APOB, APOE, INS
40adult t-cell leukemia9.9ACE, SERPINE1, VWF
41cataract 20, multiple types9.9APOB, INS, PPARA, PPARG, SERPINE1
42adrenal adenoma9.9APOB, INS, PPARA, PPARG, SERPINE1
43chronic myocardial ischemia9.9ACE, AGT, INS
44lymphocytic colitis9.9ACE, SERPINE1
45acute apical periodontitis9.9APOB, APOE, INS, PPARA, SERPINE1
46atherosclerosis9.9
47ceroid lipofuscinosis, neuronal, kufs type, adult onset9.9ACE, AGT, VWF
48calcinosis9.8ACE, AGTR1, INS
49gout9.8
50welander distal myopathy9.8AGT, AGTR1, SERPINE1

Graphical network of the top 20 diseases related to Cardiovascular Disease Risk Factor ):



Diseases related to cardiovascular disease risk factor  )

Symptoms & Phenotypes for Cardiovascular Disease Risk Factor )

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MGI Mouse Phenotypes related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5APOB, APOE, CHRNA7, INS, PPARG, SELE
2MP:00053898.4ACE, AGT, APOB, APOE, CHRNA7, INS
3MP:00053698.4AGT, APOB, APOE, INS, PPARA, PPARG
4MP:00053678.4ACE, AGT, AGTR1, APOE, INS, PPARG
5MP:00107718.0APOE, INS, PPARA, PPARG, SELE, SERPINE1
6MP:00053867.9ACE, AGT, AGTR1, APOE, CHRNA7, INS
7MP:00036317.2AGT, AGTR1, APOB, APOE, CHRNA7, INS
8MP:00053757.1ACE, AGT, AGTR1, APOE, INS, PPARA
9MP:00053846.9APOB, APOE, CHRNA7, INS, PPARA, PPARG
10MP:00053976.6ACE, AGTR1, APOE, CHRNA7, INS, PPARG
11MP:00053706.3ACE, AGT, APOB, APOE, CHRNA7, INS
12MP:00053786.3ACE, AGT, AGTR1, APOB, APOE, CHRNA7
13MP:00053855.9ACE, AGT, AGTR1, APOB, APOE, INS
14MP:00053765.5ACE, AGT, AGTR1, APOB, APOE, CHRNA7
15MP:00107685.5ACE, AGT, AGTR1, APOB, APOE, CHRNA7
16MP:00053875.4ACE, AGT, AGTR1, APOB, APOE, CHRNA7

Drugs & Therapeutics for Cardiovascular Disease Risk Factor )

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Cardiovascular Disease Risk Factor )

Genetic Tests for Cardiovascular Disease Risk Factor )

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Genetic tests related to Cardiovascular Disease Risk Factor ):

id Genetic test Affiliating Genes
1 Cardiovascular Disease Risk Factor (angiotensin Converting Enzyme (ace))24 ACE
2 Cardiovascular Disease Risk Factor (angiotensin Ii Receptor, Type 1)24 AGTR1
3 Cardiovascular Disease Risk Factor (angiotensinogen)24 AGT
4 Cardiovascular Disease Risk Factor (apolipoprotein E)24 APOE
5 Cardiovascular Disease Risk Factor (carotid Intimal Medial Thickness 1)24 PPARG

Anatomical Context for Cardiovascular Disease Risk Factor )

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MalaCards organs/tissues related to Cardiovascular Disease Risk Factor ):

36
Heart, Endothelial, Ovary, Kidney, Spinal cord

Publications for Cardiovascular Disease Risk Factor )

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Articles related to Cardiovascular Disease Risk Factor ):

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Multicenter Study of Temporal Trends in the Achievement of Atherosclerotic Cardiovascular Disease Risk Factor Goals During Cardiac Rehabilitation. (27798509)
2017
2
Erratum to: Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. (27376356)
2016
3
Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. (27209284)
2016
4
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study. (27166203)
2016
5
Traditional Cardiovascular Disease Risk Factor Management in Rheumatoid Arthritis Compared to Matched Nonrheumatoid Arthritis in a US Managed Care Setting. (26414069)
2016
6
Association Between Cardiovascular Disease Risk Factors and Rotator Cuff Tendinopathy: Cross-Sectional Study. (28002354)
2016
7
Trends in Nonlipid Cardiovascular Disease Risk Factor Management in the Women's Interagency HIV Study and Association with Adherence to Antiretroviral Therapy. (27749112)
2016
8
Objectively Measured Aerobic and Resistance Exercise and Cardiovascular Disease Risk Factor Response: 2164 Board #316 June 2, 3: 30 PM - 5: 00 PM. (27360989)
2016
9
Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross-Sectional Study. (26364955)
2015
10
When gout goes to the heart: does gout equal a cardiovascular disease risk factor? (25603830)
2015
11
Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study. (25906186)
2015
12
Outcomes of cardiovascular disease risk factor screening and referrals in a family planning clinic. (25517351)
2015
13
Clinical Variability in Cardiovascular Disease Risk Factor Screening and Management in Adolescent and Young Adult Women with Polycystic Ovary Syndrome. (26081478)
2015
14
Cardiovascular disease risk factor clustering among rural adult population in West Bengal, India. (26008793)
2015
15
Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides. (25672297)
2015
16
Cardiovascular disease risk factor profiles of 263,356 older Australians according to region of birth and acculturation, with a focus on migrants born in Asia. (25695771)
2015
17
HIV infection, cardiovascular disease risk factor profile, and risk for acute myocardial infarction. (25588033)
2015
18
Heart matters: Gender and racial differences cardiovascular disease risk factor control among veterans. (25213741)
2014
19
Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. (24716628)
2014
20
The associations between polymorphisms in the CD36 gene, fat oxidation and cardiovascular disease risk factors in a young adult Australian population: a pilot study. (25277110)
2014
21
Cardiovascular Disease Risk Factor Profiling of Group C Employees in JIPMER, Puducherry. (25374865)
2014
22
Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study. (23340887)
2013
23
Dose-response association of uncontrolled blood pressure and cardiovascular disease risk factors with hyperuricemia and gout. (23460805)
2013
24
Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002-2012 literature review. (24219205)
2013
25
Managing tobacco use: the neglected cardiovascular disease risk factor. (24014389)
2013
26
Physician cardiovascular disease risk factor management: practice analysis in Japan versus the USA. (23735635)
2013
27
Classical cardiovascular disease risk factors associate with vascular function and morphology in rheumatoid arthritis: a six-year prospective study. (24289091)
2013
28
The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. (23212717)
2013
29
A comparison of the Slaughter skinfold-thickness equations and BMI in predicting body fatness and cardiovascular disease risk factor levels in children. (24153344)
2013
30
Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial. (23187956)
2013
31
Associations of Cardiovascular Disease Risk Factors and Calcified Atherosclerosis With Aortoiliac Bifurcation Position: The Multiethnic Study of Atherosclerosis. (24375634)
2013
32
Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets. (24039358)
2013
33
Absence of cardiovascular disease risk factors in restless legs syndrome. (21718253)
2012
34
Immigration disparities in cardiovascular disease risk factor awareness. (22210443)
2012
35
Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia. (22322083)
2012
36
Social determinants of cardiovascular disease risk factor presence among rural and urban Black and White men. (22902779)
2012
37
A review of family history of cardiovascular disease: risk factor and research tool. (22607505)
2012
38
Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. (21719451)
2012
39
Cardiovascular disease risk factor patterns and their implications for intervention strategies in Vietnam. (22500217)
2012
40
Cardiovascular disease risk factor clustering among African American adults. (21749014)
2011
41
Cardiovascular disease risk factors: prevalence and management in adult hemophilia patients. (21451396)
2011
42
A cardiovascular disease risk factor screening program designed to reach rural residents of Maine, USA. (21834601)
2011
43
Physician cardiovascular disease risk factor management: practices in France vs the United States. (21214716)
2011
44
Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study. (22034506)
2011
45
Is cardiorespiratory fitness a unique cardiovascular disease risk factor? (21903066)
2011
46
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (20884846)
2010
47
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (20838585)
2010
48
Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. (20184534)
2010
49
Job demand and cardiovascular disease risk factor in white-collar workers. (20160403)
2010
50
Cardiovascular disease risk factors in persons with paraplegia: the Stockholm spinal cord injury study. (20419873)
2010

Variations for Cardiovascular Disease Risk Factor )

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Expression for genes affiliated with Cardiovascular Disease Risk Factor )

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Search GEO for disease gene expression data for Cardiovascular Disease Risk Factor ).

Pathways for genes affiliated with Cardiovascular Disease Risk Factor )

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GO Terms for genes affiliated with Cardiovascular Disease Risk Factor )

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Cellular components related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:004262710.6APOB, APOE
2endocytic vesicle lumenGO:007168210.6APOB, APOE
3endosome lumenGO:003190410.5APOB, INS
4intermediate-density lipoprotein particleGO:003436310.2APOB, APOE
5low-density lipoprotein particleGO:003436210.1APOB, APOE
6very-low-density lipoprotein particleGO:00343619.8APOB, APOE
7extracellular spaceGO:00056158.2ACE, AGT, APOB, APOE, INS, SELE
8extracellular regionGO:00055768.1ACE, AGT, APOB, APOE, INS, SERPINE1

Biological processes related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1lipid homeostasisGO:005508810.6APOE, PPARG
2long-chain fatty acid transportGO:001590910.6APOE, PPARG
3angiotensin maturationGO:000200310.6ACE, AGT
4fatty acid homeostasisGO:005508910.6APOE, INS
5cellular response to prostaglandin stimulusGO:007137910.6APOB, PPARG
6nitric oxide mediated signal transductionGO:000726310.5AGT, APOE
7artery morphogenesisGO:004884410.5APOB, APOE
8cholesterol effluxGO:003334410.5APOB, APOE
9chylomicron assemblyGO:003437810.5APOB, APOE
10chylomicron remnant clearanceGO:003438210.5APOB, APOE
11chylomicron remodelingGO:003437110.5APOB, APOE
12negative regulation of acute inflammatory responseGO:000267410.5INS, PPARG
13positive regulation of NAD(P)H oxidase activityGO:003386410.5AGT, AGTR1
14activation of phospholipase C activityGO:000720210.5AGT, SELE
15lipoprotein transportGO:004295310.5APOB, PPARG
16lipoprotein biosynthetic processGO:004215810.5APOB, APOE
17lipoprotein catabolic processGO:004215910.5APOB, APOE
18positive regulation of lipid biosynthetic processGO:004688910.5APOE, INS
19positive regulation of protein tyrosine kinase activityGO:006109810.4ACE, AGT
20positive regulation of nitric-oxide synthase activityGO:005100010.4APOE, INS
21regulation of blood vessel diameter by renin-angiotensinGO:000203410.4AGT, AGTR1
22positive regulation of vasodilationGO:004590910.4AGT, INS
23regulation of blood vessel diameterGO:009774610.4ACE, AGTR1
24regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
25regulation of renal output by angiotensinGO:000201910.4ACE, AGT
26negative regulation of beta-amyloid formationGO:190243010.3APOE, CHRNA7
27negative regulation of blood coagulationGO:003019510.3APOE, SERPINE1
28renin-angiotensin regulation of aldosterone productionGO:000201810.3AGT, AGTR1
29regulation of vasodilationGO:004231210.3ACE, AGTR1
30negative regulation of cholesterol storageGO:001088710.2PPARA, PPARG
31negative regulation of macrophage derived foam cell differentiationGO:001074510.2PPARA, PPARG
32negative regulation of receptor biosynthetic processGO:001087110.2PPARA, PPARG
33negative regulation of sequestering of triglycerideGO:001089110.2PPARA, PPARG
34positive regulation of fatty acid oxidationGO:004632110.2PPARA, PPARG
35kidney developmentGO:000182210.2ACE, AGT, AGTR1
36positive regulation of cholesterol esterificationGO:001087310.2AGT, AGTR1, APOE
37triglyceride catabolic processGO:001943310.2APOB, APOE
38regulation of blood pressureGO:000821710.2ACE, AGT, PPARG
39positive regulation of cellular protein metabolic processGO:003227010.1AGT, AGTR1, INS
40positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGT, AGTR1, APOB
41vasodilationGO:004231110.0AGT, APOE
42regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.0ACE, AGT, AGTR1
43regulation of vasoconstrictionGO:001922910.0ACE, AGT, AGTR1
44positive regulation of inflammatory responseGO:005072910.0AGT, AGTR1, SERPINE1
45lipoprotein metabolic processGO:00421579.8APOB, APOE, PPARA
46low-density lipoprotein particle remodelingGO:00343749.8AGT, AGTR1, APOB, APOE
47regulation of lipid metabolic processGO:00192169.8AGT, PPARA, PPARG
48very-low-density lipoprotein particle clearanceGO:00344479.8APOB, APOE
49G-protein coupled receptor signaling pathwayGO:00071869.6AGT, AGTR1, APOE, INS, PPARG
50lipid metabolic processGO:00066299.6APOB, APOE, PPARA, PPARG

Molecular functions related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.4ACE, AGTR1
2cholesterol transporter activityGO:001712710.4APOB, APOE
3lipid transporter activityGO:000531910.3APOB, APOE
4low-density lipoprotein particle receptor bindingGO:005075010.3APOB, APOE
5drug bindingGO:00081449.8ACE, PPARA, PPARG
6protease bindingGO:00020208.8INS, SERPINE1, VWF

Sources for Cardiovascular Disease Risk Factor )

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet