MCID: CRD144
MIFTS: 40

Cardiovascular Disease Risk Factor ) malady

Categories: Genetic diseases, Cardiovascular diseases

Aliases & Classifications for Cardiovascular Disease Risk Factor )

Aliases & Descriptions for Cardiovascular Disease Risk Factor ):

Name: Cardiovascular Disease Risk Factor ) 24
Hyperlipoproteinemia Type Iii Risk Factor 24
Coronary Artery Disease Risk Factor ) 24
Coronary Artery Disease Risk Factor 24
Cardiovascular Disease Risk Factor 24
Coronay Artery Disease Risk Factor 24

Classifications:



Summaries for Cardiovascular Disease Risk Factor )

MalaCards based summary : Cardiovascular Disease Risk Factor ), also known as hyperlipoproteinemia type iii risk factor, is related to myocardial infarction and mthfr thermolabile variant. An important gene associated with Cardiovascular Disease Risk Factor ) is PPARG (Peroxisome Proliferator Activated Receptor Gamma), and among its related pathways/superpathways are Peptide hormone metabolism and Folate Metabolism. Affiliated tissues include heart, endothelial and ovary, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Cardiovascular Disease Risk Factor )

Diseases related to Cardiovascular Disease Risk Factor ) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.1 ACE AGT AGTR1 APOB APOE INS
2 mthfr thermolabile variant 11.1
3 zap-70 deficiency 10.2 APOB APOE
4 keratoconus 4 10.2 APOB APOE
5 coronary artery disease 10.2
6 artery disease 10.2
7 x-linked amelogenesis imperfecta hypoplastic/hypomaturation 2 10.2 APOE VWF
8 dentinogenesis imperfecta type 2 10.2 APOB APOE
9 hyperlipoproteinemia type iv 10.2 APOB INS PPARG
10 lupus erythematosus panniculitis 10.2 ACE APOE
11 albinism, oculocutaneous, type v 10.2 APOB APOE
12 chondrocalcinosis with early-onset osteoarthritis 10.2 APOB APOE INS
13 primary pigmented nodular adrenocortical disease 10.2 APOB APOE INS
14 bleeding disorder, east texas type 10.1 APOB APOE INS
15 c1s deficiency 10.1 APOE INS
16 iron metabolism disease 10.1 ACE APOE
17 neonatal diabetes mellitus 10.1 INS SELE VWF
18 hypertriglyceridemia 10.1 APOB APOE PPARA
19 exostosis 10.1 APOB INS SERPINE1
20 alzheimer disease 19, late onset 10.1 APOB APOE
21 subleukemic leukemia 10.1 ACE PPARA PPARG
22 thyroid cancer, anaplastic 10.1 SELE SERPINE1 VWF
23 limb ischemia 10.1 ACE APOE INS
24 pars planitis 10.1 ACE APOE
25 immune-mediated encephalomyelitis 10.1 APOE VWF
26 penile cancer, childhood 10.0 ACE AGT
27 diabetic encephalopathy 10.0 ACE APOE INS
28 immunodeficiency 18 10.0 APOB APOE INS SERPINE1
29 listeriosis 10.0 ACE VWF
30 autosomal recessive congenital ichthyosis 10.0 INS PPARA PPARG SERPINE1
31 secretory diarrhea myopathy and deafness 10.0 ACE SERPINE1 VWF
32 ischemic optic neuropathy 10.0 ACE SERPINE1 VWF
33 obesity 10.0
34 iida kannari syndrome 10.0 ACE INS PPARA PPARG
35 mental retardation, autosomal recessive 27 10.0 AGT PPARA SERPINE1
36 optic nerve neoplasm 10.0 ACE APOB APOE SELE
37 malignant hyperthermia susceptibility 1 10.0 ACE AGT APOB
38 gait apraxia 9.9 ACE APOB APOE SERPINE1
39 narcolepsy 6 9.9 AGT APOB APOE INS
40 adult t-cell leukemia 9.9 ACE SERPINE1 VWF
41 cataract 20, multiple types 9.9 APOB INS PPARA PPARG SERPINE1
42 adrenal adenoma 9.9 APOB INS PPARA PPARG SERPINE1
43 chronic myocardial ischemia 9.9 ACE AGT INS
44 lymphocytic colitis 9.9 ACE SERPINE1
45 acute apical periodontitis 9.9 APOB APOE INS PPARA SERPINE1
46 atherosclerosis 9.9
47 ceroid lipofuscinosis, neuronal, kufs type, adult onset 9.9 ACE AGT VWF
48 calcinosis 9.8 ACE AGTR1 INS
49 gout 9.8
50 welander distal myopathy 9.8 AGT AGTR1 SERPINE1

Graphical network of the top 20 diseases related to Cardiovascular Disease Risk Factor ):



Diseases related to Cardiovascular Disease Risk Factor  )

Symptoms & Phenotypes for Cardiovascular Disease Risk Factor )

MGI Mouse Phenotypes related to Cardiovascular Disease Risk Factor ):

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.28 PPARA PPARG INS SELE SERPINE1 VWF
2 homeostasis/metabolism MP:0005376 10.26 CHRNA7 PPARA PPARG INS SELE SERPINE1
3 growth/size/body region MP:0005378 10.25 CHRNA7 PPARA PPARG INS SELE SERPINE1
4 immune system MP:0005387 10.23 PPARA CHRNA7 PPARG INS SELE SERPINE1
5 adipose tissue MP:0005375 10.16 PPARA PPARG INS SERPINE1 AGT APOE
6 behavior/neurological MP:0005386 10.15 CHRNA7 PPARG INS SELE ACE AGT
7 hematopoietic system MP:0005397 10.15 CHRNA7 PPARG INS SELE SERPINE1 VWF
8 mortality/aging MP:0010768 10.15 CHRNA7 PPARA PPARG INS SELE SERPINE1
9 cellular MP:0005384 10.13 INS APOE PPARA CHRNA7 PPARG SELE
10 liver/biliary system MP:0005370 10.1 PPARA CHRNA7 PPARG INS SELE SERPINE1
11 integument MP:0010771 9.91 INS APOE PPARA PPARG SELE SERPINE1
12 nervous system MP:0003631 9.86 APOE CHRNA7 PPARG INS VWF APOB
13 muscle MP:0005369 9.8 PPARA PPARG INS APOB AGT APOE
14 renal/urinary system MP:0005367 9.7 PPARG INS SERPINE1 ACE AGT APOE
15 reproductive system MP:0005389 9.5 CHRNA7 PPARG INS ACE APOB AGT
16 vision/eye MP:0005391 9.1 INS APOE CHRNA7 PPARG SELE APOB

Drugs & Therapeutics for Cardiovascular Disease Risk Factor )

Search Clinical Trials , NIH Clinical Center for Cardiovascular Disease Risk Factor )

Genetic Tests for Cardiovascular Disease Risk Factor )

Genetic tests related to Cardiovascular Disease Risk Factor ):

id Genetic test Affiliating Genes
1 Cardiovascular Disease Risk Factor (angiotensin Converting Enzyme (ace)) 24 ACE
2 Cardiovascular Disease Risk Factor (angiotensin Ii Receptor, Type 1) 24 AGTR1
3 Cardiovascular Disease Risk Factor (angiotensinogen) 24 AGT
4 Cardiovascular Disease Risk Factor (apolipoprotein E) 24 APOE
5 Cardiovascular Disease Risk Factor (carotid Intimal Medial Thickness 1) 24 PPARG

Anatomical Context for Cardiovascular Disease Risk Factor )

MalaCards organs/tissues related to Cardiovascular Disease Risk Factor ):

39
Heart, Endothelial, Ovary, Kidney, Spinal Cord

Publications for Cardiovascular Disease Risk Factor )

Articles related to Cardiovascular Disease Risk Factor ):

(show top 50) (show all 160)
id Title Authors Year
1
Multicenter Study of Temporal Trends in the Achievement of Atherosclerotic Cardiovascular Disease Risk Factor Goals During Cardiac Rehabilitation. ( 27798509 )
2017
2
Erratum to: Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. ( 27376356 )
2016
3
Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population. ( 27209284 )
2016
4
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study. ( 27166203 )
2016
5
Traditional Cardiovascular Disease Risk Factor Management in Rheumatoid Arthritis Compared to Matched Nonrheumatoid Arthritis in a US Managed Care Setting. ( 26414069 )
2016
6
Association Between Cardiovascular Disease Risk Factors and Rotator Cuff Tendinopathy: Cross-Sectional Study. ( 28002354 )
2016
7
Trends in Nonlipid Cardiovascular Disease Risk Factor Management in the Women's Interagency HIV Study and Association with Adherence to Antiretroviral Therapy. ( 27749112 )
2016
8
Objectively Measured Aerobic and Resistance Exercise and Cardiovascular Disease Risk Factor Response: 2164 Board #316 June 2, 3: 30 PM - 5: 00 PM. ( 27360989 )
2016
9
Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross-Sectional Study. ( 26364955 )
2015
10
When gout goes to the heart: does gout equal a cardiovascular disease risk factor? ( 25603830 )
2015
11
Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study. ( 25906186 )
2015
12
Outcomes of cardiovascular disease risk factor screening and referrals in a family planning clinic. ( 25517351 )
2015
13
Clinical Variability in Cardiovascular Disease Risk Factor Screening and Management in Adolescent and Young Adult Women with Polycystic Ovary Syndrome. ( 26081478 )
2015
14
Cardiovascular disease risk factor clustering among rural adult population in West Bengal, India. ( 26008793 )
2015
15
Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides. ( 25672297 )
2015
16
Cardiovascular disease risk factor profiles of 263,356 older Australians according to region of birth and acculturation, with a focus on migrants born in Asia. ( 25695771 )
2015
17
HIV infection, cardiovascular disease risk factor profile, and risk for acute myocardial infarction. ( 25588033 )
2015
18
Heart matters: Gender and racial differences cardiovascular disease risk factor control among veterans. ( 25213741 )
2014
19
Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. ( 24716628 )
2014
20
The associations between polymorphisms in the CD36 gene, fat oxidation and cardiovascular disease risk factors in a young adult Australian population: a pilot study. ( 25277110 )
2014
21
Cardiovascular Disease Risk Factor Profiling of Group C Employees in JIPMER, Puducherry. ( 25374865 )
2014
22
Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study. ( 23340887 )
2013
23
Dose-response association of uncontrolled blood pressure and cardiovascular disease risk factors with hyperuricemia and gout. ( 23460805 )
2013
24
Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002-2012 literature review. ( 24219205 )
2013
25
Managing tobacco use: the neglected cardiovascular disease risk factor. ( 24014389 )
2013
26
Physician cardiovascular disease risk factor management: practice analysis in Japan versus the USA. ( 23735635 )
2013
27
Classical cardiovascular disease risk factors associate with vascular function and morphology in rheumatoid arthritis: a six-year prospective study. ( 24289091 )
2013
28
The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. ( 23212717 )
2013
29
A comparison of the Slaughter skinfold-thickness equations and BMI in predicting body fatness and cardiovascular disease risk factor levels in children. ( 24153344 )
2013
30
Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial. ( 23187956 )
2013
31
Associations of Cardiovascular Disease Risk Factors and Calcified Atherosclerosis With Aortoiliac Bifurcation Position: The Multiethnic Study of Atherosclerosis. ( 24375634 )
2013
32
Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets. ( 24039358 )
2013
33
Absence of cardiovascular disease risk factors in restless legs syndrome. ( 21718253 )
2012
34
Immigration disparities in cardiovascular disease risk factor awareness. ( 22210443 )
2012
35
Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia. ( 22322083 )
2012
36
Social determinants of cardiovascular disease risk factor presence among rural and urban Black and White men. ( 22902779 )
2012
37
A review of family history of cardiovascular disease: risk factor and research tool. ( 22607505 )
2012
38
Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. ( 21719451 )
2012
39
Cardiovascular disease risk factor patterns and their implications for intervention strategies in Vietnam. ( 22500217 )
2012
40
Cardiovascular disease risk factor clustering among African American adults. ( 21749014 )
2011
41
Cardiovascular disease risk factors: prevalence and management in adult hemophilia patients. ( 21451396 )
2011
42
A cardiovascular disease risk factor screening program designed to reach rural residents of Maine, USA. ( 21834601 )
2011
43
Physician cardiovascular disease risk factor management: practices in France vs the United States. ( 21214716 )
2011
44
Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study. ( 22034506 )
2011
45
Is cardiorespiratory fitness a unique cardiovascular disease risk factor? ( 21903066 )
2011
46
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. ( 20884846 )
2010
47
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. ( 20838585 )
2010
48
Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. ( 20184534 )
2010
49
Job demand and cardiovascular disease risk factor in white-collar workers. ( 20160403 )
2010
50
Cardiovascular disease risk factors in persons with paraplegia: the Stockholm spinal cord injury study. ( 20419873 )
2010

Variations for Cardiovascular Disease Risk Factor )

Expression for Cardiovascular Disease Risk Factor )

Search GEO for disease gene expression data for Cardiovascular Disease Risk Factor ).

Pathways for Cardiovascular Disease Risk Factor )

GO Terms for Cardiovascular Disease Risk Factor )

Cellular components related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.98 ACE AGT APOB APOE INS SERPINE1
2 very-low-density lipoprotein particle GO:0034361 9.4 APOB APOE
3 endosome lumen GO:0031904 9.37 APOB INS
4 endocytic vesicle lumen GO:0071682 9.32 APOB APOE
5 low-density lipoprotein particle GO:0034362 9.26 APOB APOE
6 extracellular space GO:0005615 9.17 ACE AGT APOB APOE INS SELE
7 chylomicron GO:0042627 9.16 APOB APOE
8 intermediate-density lipoprotein particle GO:0034363 8.96 APOB APOE

Biological processes related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

(show all 50)
id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.83 ACE AGT AGTR1
2 regulation of lipid metabolic process GO:0019216 9.82 AGT PPARA PPARG
3 regulation of blood pressure GO:0008217 9.78 ACE AGT PPARG
4 positive regulation of inflammatory response GO:0050729 9.74 AGT AGTR1 SERPINE1
5 lipoprotein metabolic process GO:0042157 9.71 APOB APOE PPARA
6 positive regulation of protein tyrosine kinase activity GO:0061098 9.7 ACE AGT
7 positive regulation of vasodilation GO:0045909 9.7 AGT INS
8 lipid homeostasis GO:0055088 9.7 APOE PPARG
9 activation of phospholipase C activity GO:0007202 9.7 AGT SELE
10 triglyceride catabolic process GO:0019433 9.69 APOB APOE
11 cholesterol efflux GO:0033344 9.69 APOB APOE
12 vasodilation GO:0042311 9.69 AGT APOE
13 artery morphogenesis GO:0048844 9.68 APOB APOE
14 positive regulation of nitric-oxide synthase activity GO:0051000 9.68 APOE INS
15 nitric oxide mediated signal transduction GO:0007263 9.68 AGT APOE
16 lipoprotein transport GO:0042953 9.68 APOB PPARG
17 regulation of vasodilation GO:0042312 9.67 ACE AGTR1
18 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 PPARA PPARG
19 negative regulation of blood coagulation GO:0030195 9.67 APOE SERPINE1
20 fatty acid homeostasis GO:0055089 9.66 APOE INS
21 long-chain fatty acid transport GO:0015909 9.65 APOE PPARG
22 positive regulation of lipid biosynthetic process GO:0046889 9.65 APOE INS
23 angiotensin maturation GO:0002003 9.65 ACE AGT
24 lipoprotein biosynthetic process GO:0042158 9.64 APOB APOE
25 chylomicron assembly GO:0034378 9.63 APOB APOE
26 regulation of blood vessel diameter GO:0097746 9.63 ACE AGTR1
27 chylomicron remodeling GO:0034371 9.62 APOB APOE
28 chylomicron remnant clearance GO:0034382 9.62 APOB APOE
29 negative regulation of acute inflammatory response GO:0002674 9.61 INS PPARG
30 negative regulation of cholesterol storage GO:0010887 9.6 PPARA PPARG
31 negative regulation of beta-amyloid formation GO:1902430 9.59 APOE CHRNA7
32 very-low-density lipoprotein particle clearance GO:0034447 9.58 APOB APOE
33 positive regulation of fatty acid oxidation GO:0046321 9.58 PPARA PPARG
34 negative regulation of sequestering of triglyceride GO:0010891 9.56 PPARA PPARG
35 positive regulation of NAD(P)H oxidase activity GO:0033864 9.55 AGT AGTR1
36 regulation of vasoconstriction GO:0019229 9.54 ACE AGT AGTR1
37 renin-angiotensin regulation of aldosterone production GO:0002018 9.52 AGT AGTR1
38 regulation of renal sodium excretion GO:0035813 9.51 AGT AGTR1
39 positive regulation of cellular protein metabolic process GO:0032270 9.5 AGT AGTR1 INS
40 lipoprotein catabolic process GO:0042159 9.49 APOB APOE
41 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.48 AGT AGTR1
42 cellular response to prostaglandin stimulus GO:0071379 9.46 APOB PPARG
43 negative regulation of receptor biosynthetic process GO:0010871 9.43 PPARA PPARG
44 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.43 AGT AGTR1 APOB
45 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
46 positive regulation of cholesterol esterification GO:0010873 9.33 AGT AGTR1 APOE
47 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
48 low-density lipoprotein particle remodeling GO:0034374 8.92 AGT AGTR1 APOB APOE
49 G-protein coupled receptor signaling pathway GO:0007186 10.1 AGT AGTR1 APOE INS PPARG
50 lipid metabolic process GO:0006629 10.01 APOB APOE PPARA PPARG

Molecular functions related to Cardiovascular Disease Risk Factor ) according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 9.37 APOB APOE
2 protease binding GO:0002020 9.33 INS SERPINE1 VWF
3 cholesterol transporter activity GO:0017127 9.32 APOB APOE
4 low-density lipoprotein particle receptor binding GO:0050750 9.26 APOB APOE
5 drug binding GO:0008144 9.13 ACE PPARA PPARG
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Cardiovascular Disease Risk Factor )

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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