CAR
MCID: CRN008
MIFTS: 68

Carney Complex (CAR) malady

Eye, Skin, Endocrine, Cancer, Genetic categories

Summaries for Carney Complex

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Carney complex is a hereditary cancer syndrome characterized by spotty skin pigmentation, cardiac (heart) myxomas (tumors composed of mucous connective tissue), skin myxomas, and endocrine gland tumors. some families with this condition have been found to have mutations in the prkar1a gene. carney syndrome is believed to be inherited in an autosomal dominant manner, which means that an affected parent has a 50% chance of passing on the affected gene to each of his/her children. last updated: 3/22/2010

MalaCards: Carney Complex, also known as carney complex, type 1, is related to adenoma and mccune albright syndrome, and has symptoms including osteoarthritis, generalized obesity and motor deficit/trouble. An important gene associated with Carney Complex is PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha), and among its related pathways are NgR-p75(NTR)-Mediated Signaling and Melanocyte Development and Pigmentation. The compounds estrogen and glucose have been mentioned in the context of this disorder. Affiliated tissues include skin, thymus and heart, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Genetics Home Reference:21 Carney complex is a disorder characterized by an increased risk of several types of tumors. Affected individuals also usually have changes in skin coloring (pigmentation). Signs and symptoms of this condition commonly begin in the teens or early adulthood.

Wikipedia:64 Carney complex and its subsets LAMB syndrome and NAME syndrome are autosomal dominant conditions... more...

Description from OMIM:47 160980,605244

GeneReviews summary for carney

Aliases & Classifications for Carney Complex

Sources:
8Disease Ontology, 9diseasecard, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 49Orphanet, 61UMLS, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Eye, Skin, Endocrine


Characteristics (Orphanet epidemiological data):

49
carney complex:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

carney complex 8 19 43 20 22 21 10 49 61
carney complex, type 1 8 9 22 47 61
carney syndrome 8 19 43 21 49
carney complex, type ii 9 22 47
lamb syndrome 8 43
lamb - lentigines, atrial myxoma, mucocutaneous myoma, blue nevus syndrome 21
name - nevi, atrial myxoma, skin myxoma, ephelides syndrome 21
myxoma - spotty pigmentation - endocrine overactivity 49
carney myxoma-endocrine complex 43
carney complex, type 2 8
familial myxoma 19
name syndrome 8
cnc1 43
car 43


External Ids:

Disease Ontology8 DOID:0050471
MeSH35 D056733
MESH via Orphanet36 D056733
ICD10 via Orphanet26 D44.8
SNOMED-CT via Orphanet58 239132009
UMLS via Orphanet62 C0406810, C2607929

Related Diseases for Carney Complex

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Carney Complex family:

carney complex variant

Diseases related to Carney Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8GNAS, STK11, MEN1, GH1, PRKAR1A, SYP
2mccune albright syndrome30.4GH1, GNAS
3peutz-jeghers syndrome30.4VHL, STK11, PRKAR1A, CNC, PTEN
4multiple endocrine neoplasia30.4VHL, GNAS, MEN1, CNC, CHGA, PRKAR1A
5adrenal adenoma30.3GNAS, MEN1, PRKAR1A, CNC
6cowden disease30.3LYPD1, PTEN, CNC, STK11
7pituitary tumors30.3GNAS, MEN1, GH1, PRKAR1A, CHGA, AIP
8hypercalcemia30.2CHGA, PRKAR1A, MEN1
9sertoli cell tumor30.1SYP
10gigantism30.1AIP, GH1, GNAS
11thyroid cancer30.1PTEN, CHGA, PRKAR1A, GNAS
12acromegaly30.1CNC, AIP, PRKAR1A, GH1, MEN1, GNAS
13cushing's syndrome30.0CNC, CHGA, SYP, PRKAR1A, GH1, MEN1
14wilms tumor30.0VHL
15squamous cell carcinoma29.8VHL, GNAS, STK11, AKT2, SYP, CHGA
16adenocarcinoma29.8VHL, STK11, MEN1, AKT2, F13A1, SYP
17myxoma-spotty pigmentation-endocrine overactivity10.6
18n syndrome10.5
19primary pigmented nodular adrenocortical disease10.5
20carney complex variant10.5
21peutz–jeghers syndrome10.3
22mccune–albright syndrome10.3
23inflammatory myofibroblastic tumor10.2
24adrenal gland disease10.2
25atrial myxoma, familial10.2
26acute leukemia10.1
27whiplash10.1
28chondrodysplasia10.1
29intracranial aneurysm10.1
30growth hormone secreting pituitary adenoma10.1
31breast ductal adenoma10.1
32ectopic thymus10.1
33myxosarcoma10.1
34infertility10.1
35adrenal carcinoma10.1
36breast adenoma10.1
37micro syndrome10.1
38short syndrome10.1
39acth-independent macronodular adrenal hyperplasia10.1
40cushing syndrome, familial10.1
41doyne honeycomb retinal dystrophy10.1
42virilizing ovarian tumor10.1
43cerebral aneurysms10.1
44thyroid carcinoma, follicular, somatic10.1
45pigmented nodular adrenocortical disease, primary, 110.1
46teratoma10.1
47benign schwannoma10.1
48autistic disorder10.0
49hypoparathyroidism10.0
50acute myeloid leukemia10.0

Graphical network of the top 20 diseases related to Carney Complex:



Diseases related to carney complex

Clinical Features for Carney Complex

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

160980,605244

Clinical synopsis from OMIM:

160980

Symptoms:

49 (show all 55)
  • osteoarthritis
  • generalized obesity
  • motor deficit/trouble
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • kyphosis
  • autosomal dominant inheritance
  • pigmented naevi/naevus pigmentosus/lentigo
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • chronic arterial hypertension
  • precocious puberty
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • coarse face
  • insulin-independent/type 2 diabetes
  • psychic/behavioural troubles
  • asthenia/fatigue/weakness
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • anaemia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • hirsutism/hypertrichosis/increased body hair
  • thin skin
  • heart/cardiac failure
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • undescended/ectopic testes/cryptorchidia/unfixed testes
  • transient cerebral ischemia/stroke
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • striae
  • tall stature/gigantism/growth acceleration
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • round face
  • skin tumors/lumps/epidermal cysts
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • cortico-adrenal hyperplasia/hypersecretion
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • gynecomastia/breast/mammary gland enlargement/hyperplasia
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • adrenal neoplasm/tumor/carcinoma/cancer
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)
  • abnormal pigmentation of the oral mucosa/gingivae
  • thyroid neoplasm/tumor/carcinoma/cancer
  • large hand
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • cushingoid morphotype
  • truncal obesity
  • mitral valve atresia/stenosis/narrowing
  • broad foot
  • abnormal fat distribution/lipodystrophy
  • heart/cardiac tumor
  • acromegaly
  • endocrine tumor

Drugs & Therapeutics for Carney Complex

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Carney Complex

Drug clinical trials:

Search ClinicalTrials for Carney Complex

Search NIH Clinical Center for Carney Complex

Search CenterWatch for Carney Complex

Genetic Tests for Carney Complex

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Carney Complex:

id Genetic test Affiliating Genes
1 Carney Complex20 22 PRKAR1A
2 Carney Complex, Type 122
3 Carney Complex, Type 222

Anatomical Context for Carney Complex

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Carney Complex:

33
Skin, Thymus, Heart, Pancreas, Thyroid, Adrenal gland, Breast, B cells, Pituitary

Animal Models for Carney Complex or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Carney Complex

Sources:
51PubMed
See all sources

Articles related to Carney Complex:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
Tumorectomy with right thoracotomy for synchronous left atrial myxomas from Carney complex: report of a case. (23052755)
2014
2
PKA RII+ Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease. (24316401)
2014
3
Systematic screening for PRKAR1A gene rearrangement in Carney complex: identification and functional characterization of a new in-frame deletion. (24144965)
2014
4
Acromegaly in a patient with Carney's complex. (22925952)
2013
5
Carney complex. (23652670)
2013
6
A complicated case of Carney complex: fifth reoperative cardiac surgery for resection of recurrent cardiac myxoma. (23866852)
2013
7
An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other. (22785148)
2012
8
Epithelioid blue nevus not associated with Carney complex in a Korean patient. (22772645)
2012
9
Resection of multiple recurrent cardiac myxomas in an adult man with Carney's complex. (22632512)
2012
10
Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer. (22514108)
2012
11
In vitro studies of novel PRKAR1A mutants that extend the predicted RII+ protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RII+ haploinsufficiency and Carney complex. (22205709)
2012
12
Spectrum of cutaneous and soft tissue lesions in two Carney complex patients-adnexal induction versus authentic adnexal neoplasms. (22588545)
2012
13
A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancer. (22112814)
2012
14
Cutaneous and cardiac myxomas in a patient with carney complex. (22795811)
2012
15
Utility of genetic testing in multisite myxoma to rule out Carney complex. (21429888)
2011
16
Anesthetic experiences of myxoma removal surgery in two patients with Carney complex -A report of two cases-. (22220234)
2011
17
Carney-Complex: multiple resections of recurrent cardiac myxoma. (21291531)
2011
18
Early recurrent left atrial myxoma in a teenager with de novo mutation of Carney complex. (22090725)
2011
19
Virilizing ovarian stromal tumor in a young woman with Carney complex. (21934476)
2011
20
Carney Complex: case report and review. (21375769)
2011
21
Carney complex: Clinical and genetic 2010 update. (20850710)
2010
22
Carney complex and lentiginosis. (19650827)
2009
23
8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors. (19773399)
2009
24
Intraductal papillary mucinous tumor of the pancreas in 2 twin brothers diagnosed as having the carney complex. (19238031)
2009
25
Ectopic thymus presenting as a thyroid nodule in a patient with the Carney complex. (19265501)
2009
26
Cutaneous signs are important in the diagnosis of the rare neoplasia syndrome Carney complex. (19219454)
2009
27
A deletion in the PRKAR1A gene is associated with Carney complex. (18780607)
2008
28
Intrathoracic psammomatous melanotic schwannoma associated with the Carney complex. (18640357)
2008
29
Case report of familial Carney complex due to novel frameshift mutation c.597del C (p.Phe200LeufsX6) in PRKAR1A. (18760947)
2008
30
Absence of PRKAR1A loss of heterozygosity in laser-captured microdissected pigmented nodular adrenocortical tissue from a patient with Carney complex caused by the novel nonsense mutation p.Y21X]. (19169478)
2008
31
The use of positron emission tomography-computed tomography scan in the evaluation of a patient with Carney complex. (18685116)
2008
32
Primary pigmented nodular adrenocortical disease (PPNAD) and pituitary adenoma in a boy with sporadic Carney complex due to a novel, de novo paternal PRKAR1A mutation (R96X). (17396442)
2007
33
Carney complex. (16798242)
2006
34
Pituitary pathology in patients with Carney Complex: growth-hormone producing hyperplasia or tumors and their association with other abnormalities. (17001464)
2006
35
Ocular findings in Carney complex]. (17199165)
2006
36
A six month mitotane course induced sustained correction of hypercortisolism in a young woman with PPNAD and Carney complex. (15816372)
2005
37
Carney complex. (15748581)
2004
38
Carney complex. (11859214)
2002
39
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. (12424709)
2002
40
The Carney complex: a rare differential diagnosis in cases with pituitary adenoma and testicular Sertoli cell tumour. (11795931)
2001
41
Carney complex--an unexpected finding during puerperium. (11306912)
2001
42
Epithelioid blue nevus: a rare variant of blue nevus not always associated with the Carney complex. (10847545)
2000
43
Neurosurgical implications of Carney complex. (10701527)
2000
44
Genetics of Carney complex and related familial lentiginoses, and other multiple tumor syndromes. (10704431)
2000
45
Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex. (10974026)
2000
46
Epithelioid blue nevus occurring in children with no evidence of Carney complex. (10535581)
1999
47
Carney complex: in a patient with multiple blue naevi and lentigines, suspect cardiac myxoma. (10439529)
1999
48
Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex). (8855810)
1996
49
Multiple cutaneous myxomas. Report of a case without other elements of Carney's complex. (8835175)
1995
50
Carney's complex in a patient with hormone-producing Sertoli cell tumor of the testicle. (8411442)
1993

Genetic Variations for Carney Complex

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Carney Complex:

63
id Symbol AA change Variation SNP ID
1PRKAR1Ap.Ser9AsnVAR_046894
2PRKAR1Ap.Arg74CysVAR_046895
3PRKAR1Ap.Arg146SerVAR_046896
4PRKAR1Ap.Asp183TyrVAR_046897
5PRKAR1Ap.Ala213AspVAR_046898
6PRKAR1Ap.Gly289TrpVAR_046899

Expression for genes affiliated with Carney Complex

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carney Complex

Search GEO for disease gene expression data for Carney Complex.

Pathways for genes affiliated with Carney Complex

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 54Reactome, 50PharmGKB
See all sources

Pathways related to Carney Complex according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PRKAR2B, PRKAR1A, PRKAR2A
29.7PRKAR2A, PRKAR1A, PRKAR2B
39.7PRKAR2A, PRKAR1A, PRKAR2B
49.7PRKAR2B, PRKAR1A, PRKAR2A
59.7PRKAR2B, PRKAR1A, PRKAR2A
69.7PRKAR2A, PRKAR1A, PRKAR2B
7
Hide members
9.5AKT2, PRKAR2B, PRKAR1A, PRKAR2A
8
Development A3 receptor signaling
Hide members
9.5AKT2, PRKAR2B, PRKAR1A, PRKAR2A
9
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, AKT2
109.5PRKAR2A, PRKAR1A, PRKAR2B, AKT2
11
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GH1
129.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
13
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
14
Hide members
9.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
15
Hide members
9.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
16
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
17
Signal transduction cAMP signaling
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
18
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
9.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
19
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
209.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
21
Hide members
9.4MYH8, PRKAR2A, PRKAR1A, PRKAR2B, STK11
22
Development Leptin signaling via PI3K-dependent pathway
Hide members
9.4STK11, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
239.4STK11, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
24
Hide members
9.4STK11, GH1, PRKAR2B, PRKAR1A, PRKAR2A
25
Hide members
9.4GNAS, STK11, PRKAR2B, PRKAR1A, PRKAR2A
26
Hide members
9.3PRKAR2B, PRKAR1A, PRKAR2A, MYH8, PTEN
27
Hide members
9.3AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
28
Hide members
9.3AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
29
Hide members
9.3AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
30
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
31
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
32
Development A2B receptor- action via G-protein alpha s
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
33
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
34
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
35
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
36
Hide members
9.3AKT2, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
37
Hide members
9.3PTEN, PRKAR2A, PRKAR1A, PRKAR2B, AKT2
38
Hide members
9.3GH1, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
39
Hide members
9.2AKT2, PRKAR2B, PRKAR1A, PRKAR2A, MYH8, PTEN
40
Hide members
9.2VHL, AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
41
Hide members
9.1AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
42
Hide members
9.1AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
43
Hide members
9.0AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A, MYH8
44
Translation Insulin regulation of translation
Hide members
9.0STK11, AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
45
Hide members
8.9PTEN, PRKAR2A, PRKAR1A, PRKAR2B, AKT2, GNAS
46
Hide members
8.9GNAS, PDE11A, AKT2, F13A1, PRKAR2B, PRKAR1A
47
Hide members
8.7VHL, STK11, AKT2, GH1, PRKAR2B, PRKAR1A
48
Hide members
8.4GNAS, PDE11A, STK11, MEN1, AKT2, GH1

Compounds for genes affiliated with Carney Complex

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Carney Complex according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7F13A1
2glucose4510.5PTEN, STK11
3smcc4510.4SYP, CHGA
4forskolin45 50 1112.4PRKAR1A, PRKAR2B
5111in-pentetreotide4510.4CHGA, SYP
6l-amino acid4510.3CHGA, SYP, PRKAR1A
7s 1004510.3F13A1, SYP, CHGA
8Cyclic Adenosine Monophosphate1110.3PRKAR1A, PRKAR2B
9b 7234510.3F13A1, SYP, CHGA
10octreotide45 60 29 1113.2GNAS, GH1, CHGA
11pka inhibitor fragment (6-22) amide6010.1PRKAR1A, PRKAR2B, PRKAR2A
12camps-sp, triethylammonium salt6010.1PRKAR2A, PRKAR1A, PRKAR2B
13pki 14-22 amide, myristoylated6010.1PRKAR2B, PRKAR1A, PRKAR2A
14h 89 dihydrochloride6010.1PRKAR2B, PRKAR1A, PRKAR2A
15reticulin4510.1SYP, F13A1
16silver4510.1CHGA, SYP, F13A1
17hematoxylin4510.1F13A1, SYP, CHGA, PTEN
18kt 572045 29 6012.1PRKAR2A, PRKAR1A, PRKAR2B
19acth4510.1CHGA, SYP, GH1, GNAS
20amine4510.0CHGA, SYP, F13A1
21guanine45 11 2412.0GNAS, STK11, GH1, SYP, CHGA
22histidine4510.0VHL, GNAS, SYP, CHGA
23vitamin d459.9MEN1, GH1, PRKAR1A, CHGA, PTEN
24tamoxifen45 50 29 1112.9AKT2, GH1, CHGA, PTEN
25adenylate459.8GNAS, STK11, GH1, PRKAR1A, CHGA
26glycogen45 2410.8VHL, STK11, AKT2, SYP, CHGA, PTEN
275-hydroxytryptophan459.8CHGA, GH1
28paraffin459.8STK11, GH1, F13A1, SYP, CHGA, PTEN
29norepinephrine45 11 2411.7GNAS, GH1, SYP, CHGA
30rapamycin459.7VHL, STK11, AKT2, PTEN
31progesterone45 60 29 11 2413.6GNAS, GH1, F13A1, SYP, CHGA, PTEN
32cysteine459.5GNAS, GH1, PRKAR1A, SYP, CHGA, PTEN
33steroid459.5GNAS, GH1, PRKAR1A, SYP, CHGA, ACBD3
34oligonucleotide459.5VHL, GNAS, AKT2, GH1, F13A1, CHGA
35lipid459.5GNAS, STK11, AKT2, GH1, SYP, CHGA
36vegf459.4VHL, STK11, MEN1, GH1, F13A1, SYP
37tyrosine459.3VHL, GNAS, MEN1, AKT2, GH1, SYP
38serine459.2VHL, GNAS, STK11, MEN1, AKT2, GH1
39calcium45 50 11 2412.2VHL, GNAS, STK11, MEN1, F13A1, PRKAR1A
40cyclic amp45 249.8PTEN, GNAS, PDE11A, STK11, PRKAR2B, PRKAR1A

GO Terms for genes affiliated with Carney Complex

Sources:
16Gene Ontology
See all sources

Cellular components related to Carney Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:03158810.0PRKAR2A, PRKAR1A
2cAMP-dependent protein kinase complexGO:0059529.6PRKAR2B, PRKAR1A, PRKAR2A
3protein complexGO:0432349.6SYP, PRKAR1A, MEN1, STK11
4cytosolGO:0058298.1PTEN, VHL, GNAS, PDE11A, STK11, MEN1

Biological processes related to Carney Complex according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1tissue homeostasisGO:00189410.1STK11, GNAS
2negative regulation of organ growthGO:04662110.1MEN1, PTEN
3negative regulation of cAMP-dependent protein kinase activityGO:200048010.0PRKAR2A, PRKAR1A, PRKAR2B
4activation of protein kinase A activityGO:0341999.9PRKAR2A, PRKAR1A, PRKAR2B
5cellular response to glucagon stimulusGO:0713779.8GNAS, PRKAR2B, PRKAR1A, PRKAR2A
6activation of phospholipase C activityGO:0072029.8PRKAR2A, PRKAR1A, PRKAR2B
7water transportGO:0068339.8GNAS, PRKAR2B, PRKAR1A, PRKAR2A
8regulation of insulin secretionGO:0507969.7GNAS, PRKAR2B, PRKAR1A, PRKAR2A
9energy reserve metabolic processGO:0061129.6PRKAR2A, PRKAR1A, PRKAR2B, STK11, GNAS
10fibroblast growth factor receptor signaling pathwayGO:0085439.6PTEN, PRKAR2A, PRKAR1A, PRKAR2B
11epidermal growth factor receptor signaling pathwayGO:0071739.6PRKAR2B, PRKAR1A, PRKAR2A, PTEN
12blood coagulationGO:0075969.2GNAS, PDE11A, F13A1, PRKAR2B, PRKAR1A, PRKAR2A
13neurotrophin TRK receptor signaling pathwayGO:0480119.2PTEN, PRKAR2A, PRKAR1A, PRKAR2B
14signal transductionGO:0071659.0PDE11A, AKT2, PRKAR2B, PRKAR1A, PRKAR2A, AIP

Molecular functions related to Carney Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP-dependent protein kinase regulator activityGO:0086039.7PRKAR2A, PRKAR1A, PRKAR2B
2cAMP-dependent protein kinase inhibitor activityGO:0048629.6PRKAR2B, PRKAR1A, PRKAR2A
3cAMP bindingGO:0305529.5PRKAR2A, PRKAR1A, PRKAR2B, PDE11A
4protein kinase A catalytic subunit bindingGO:0342369.4PRKAR2A, PRKAR1A, PRKAR2B

Products for genes affiliated with Carney Complex

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carney Complex

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet