CAR
MCID: CRN008
MIFTS: 78

Carney Complex (CAR) malady

Eye diseases, Skin diseases, Endocrine diseases, Cancer diseases, Genetic diseases categories

Summaries for Carney Complex

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Carney complex is a hereditary cancer syndrome characterized by spotty skin pigmentation, cardiac (heart) myxomas (tumors composed of mucous connective tissue), skin myxomas, and endocrine gland tumors. some families with this condition have been found to have mutations in the prkar1a gene. carney syndrome is believed to be inherited in an autosomal dominant manner, which means that an affected parent has a 50% chance of passing on the affected gene to each of his/her children. last updated: 3/22/2010

MalaCards: Carney Complex, also known as carney complex, type 1, is related to adenoma and pituitary adenoma, and has symptoms including hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies, abnormal pigmentation of the oral mucosa/gingivae and skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma). An important gene associated with Carney Complex is PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha), and among its related pathways are NgR-p75(NTR)-Mediated Signaling and Melanocyte Development and Pigmentation. The compounds estrogen and glucose have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and pituitary, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Genetics Home Reference:21 Carney complex is a disorder characterized by an increased risk of several types of tumors. Affected individuals also usually have changes in skin coloring (pigmentation). Signs and symptoms of this condition commonly begin in the teens or early adulthood.

Wikipedia:63 Carney complex and its subsets LAMB syndrome and NAME syndrome are autosomal dominant conditions... more...

Description from OMIM:46 160980,605244

GeneReviews summary for carney

Aliases & Classifications for Carney Complex

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Sources:
8Disease Ontology, 9diseasecard, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
carney complex:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

carney complex 8 19 42 20 22 21 10 48 60
carney complex, type 1 8 9 22 46 60
carney syndrome 8 19 42 21 48
carney complex, type ii 9 22 46
lamb syndrome 8 42
lamb - lentigines, atrial myxoma, mucocutaneous myoma, blue nevus syndrome 21
name - nevi, atrial myxoma, skin myxoma, ephelides syndrome 21
myxoma - spotty pigmentation - endocrine overactivity 48
carney myxoma-endocrine complex 42
carney complex, type 2 8
familial myxoma 19
name syndrome 8
cnc1 42
car 42


External Ids:

Disease Ontology8 DOID:0050471
MeSH34 D056733
MESH via Orphanet35 D056733
ICD10 via Orphanet26 D44.8
SNOMED-CT via Orphanet57 239132009
UMLS via Orphanet61 C0406810, C2607929

Related Diseases for Carney Complex

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17GeneCards, 18GeneDecks
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Diseases in the Carney Complex family:

Carney Complex Variant

Diseases related to Carney Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8GNAS, STK11, MEN1, GH1, PRKAR1A, SYP
2pituitary adenoma30.7GNAS, MEN1, GH1, PRKAR1A, SYP, CHGA
3mccune albright syndrome30.4GH1, GNAS
4peutz-jeghers syndrome30.4VHL, STK11, PRKAR1A, CNC, PTEN
5adrenal adenoma30.3GNAS, MEN1, PRKAR1A, CNC
6neuroendocrine tumor30.3GNAS, MEN1, GH1, SYP, CHGA
7hyperparathyroidism30.2MEN1, PRKAR1A, CHGA
8leukemia30.1MEN1, PRKAR2B
9hypercalcemia30.1CHGA, PRKAR1A, MEN1
10sertoli cell tumor30.0SYP
11von hippel-lindau disease30.0MEN1, VHL
12gigantism30.0AIP, GH1, GNAS
13melanoma30.0STK11, F13A1, PTEN
14cowden disease30.0LYPD1, PTEN, CNC, STK11
15thyroid cancer30.0PTEN, CHGA, PRKAR1A, GNAS
16hepatocellular carcinoma30.0PTEN, F13A1, MEN1, STK11
17acromegaly30.0CNC, AIP, PRKAR1A, GH1, MEN1, GNAS
18cushing's syndrome30.0CNC, CHGA, SYP, PRKAR1A, GH1, MEN1
19wilms tumor30.0VHL
20lung cancer30.0STK11, AKT2, SYP, CHGA
21breast cancer30.0STK11, AKT2, SYP, CHGA, PTEN
22goiter29.7GNAS
23squamous cell carcinoma29.7VHL, GNAS, STK11, AKT2, SYP, CHGA
24adenocarcinoma29.7VHL, STK11, MEN1, AKT2, F13A1, SYP
25myxoma-spotty pigmentation-endocrine overactivity10.6
26pigmentation disease10.5
27carney complex variant10.4
28thyroiditis10.3
29motion sickness10.2
30hepatitis10.2
31adrenal gland disease10.2
32neuronitis10.1
33inflammatory myofibroblastic tumor10.1
34acute t cell leukemia10.1
35acute leukemia10.1
36myeloma10.1
37rhabdomyosarcoma10.1
38t-cell leukemia10.1
39cerebritis10.0
40intracranial aneurysm10.0
41growth hormone secreting pituitary adenoma10.0
42breast ductal adenoma10.0
43ectopic thymus10.0
44myxosarcoma10.0
45infertility10.0
46adrenal carcinoma10.0
47breast adenoma10.0
48hyperthyroidism10.0
49male infertility10.0
50ovarian disease10.0

Graphical network of the top 20 diseases related to Carney Complex:



Diseases related to carney complex

Clinical Features for Carney Complex

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

160980,605244

Clinical synopsis from OMIM:

160980

Symptoms:

48 (show all 55)
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • abnormal pigmentation of the oral mucosa/gingivae
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)
  • adrenal neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • breast neoplasm/tumor/carcinoma/cancer
  • gynecomastia/breast/mammary gland enlargement/hyperplasia
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • cortico-adrenal hyperplasia/hypersecretion
  • thyroid neoplasm/tumor/carcinoma/cancer
  • large hand
  • testicular/seminal neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • chronic arterial hypertension
  • endocrine tumor
  • acromegaly
  • heart/cardiac tumor
  • abnormal fat distribution/lipodystrophy
  • broad foot
  • mitral valve atresia/stenosis/narrowing
  • truncal obesity
  • cushingoid morphotype
  • skin tumors/lumps/epidermal cysts
  • round face
  • fever/chilling
  • asthenia/fatigue/weakness
  • psychic/behavioural troubles
  • insulin-independent/type 2 diabetes
  • coarse face
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • precocious puberty
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • pigmented naevi/naevus pigmentosus/lentigo
  • autosomal dominant inheritance
  • kyphosis
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • motor deficit/trouble
  • generalized obesity
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • tall stature/gigantism/growth acceleration
  • striae
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • transient cerebral ischemia/stroke
  • undescended/ectopic testes/cryptorchidia/unfixed testes
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • heart/cardiac failure
  • thin skin
  • hirsutism/hypertrichosis/increased body hair
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anaemia
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • osteoarthritis

Drugs & Therapeutics for Carney Complex

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Carney Complex

Drug clinical trials:

Search ClinicalTrials for Carney Complex

Search NIH Clinical Center for Carney Complex

Search CenterWatch for Carney Complex

Genetic Tests for Carney Complex

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20GeneTests, 22GTR
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Genetic tests related to Carney Complex:

id Genetic test Affiliating Genes
1 Carney Complex20 22 PRKAR1A
2 Carney Complex, Type 122
3 Carney Complex, Type 222

Anatomical Context for Carney Complex

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32MalaCards
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MalaCards organs/tissues related to Carney Complex:

32
Skin, Heart, Pituitary, Testes, Breast, Thyroid, Hypothalamus, Ovary, Eye, Adrenal gland, Thymus, Pancreas

Animal Models for Carney Complex or affiliated genes

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36MGI
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Publications for Carney Complex

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50PubMed
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Articles related to Carney Complex:

(show top 50)    (show all 179)
idTitleAuthorsYear
1
Hepato-pancreato-biliary lesions are present in both Carney complex and McCune Albright syndrome: comments on P. Salpea and C. Stratakis. (24161590)
2014
2
Carney Complex with Right Ventricular Myxoma following Second Excision of Left Atrial Myxoma. (23995348)
2013
3
Carney Complex with Biatrial Cardiac Myxoma. (24088910)
2013
4
Carney complex and McCune Albright syndrome: An overview of clinical manifestations and human molecular genetics. (24012779)
2013
5
The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation. (23315333)
2013
6
Recurrent left atrial myxomas in Carney complex: a genetic cause of multiple strokes that can be prevented. (22341669)
2012
7
Biatrial myxomas with Carney complex. (22879562)
2012
8
Novel genetic mutation in the background of Carney complex. (22297707)
2012
9
Malignant psammomatous melanotic schwannoma of the spine: A component of Carney complex. (22059131)
2011
10
Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association. (21900385)
2011
11
Recurrent atrial myxoma: resection for Carney complex through a minimally invasive approach. (20487111)
2010
12
Clinical and molecular genetics of Carney complex. (20833331)
2010
13
A novel PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease and the Carney complex. (19833579)
2010
14
Carney complex: a case report. (19438156)
2009
15
Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a PRKAR1A mutation. (19178533)
2009
16
Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene. (19539840)
2009
17
Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex. (19522826)
2009
18
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis. (19577711)
2009
19
Possible association between Carney complex and multiple endocrine neoplasia type 1 phenotypes. (19169494)
2008
20
A novel PRKAR1A mutation associated with hepatocellular carcinoma in a young patient and a variable Carney complex phenotype in affected subjects in older generations. (18445140)
2008
21
Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis. (17975024)
2008
22
Heterogeneity of skin manifestations in patients with Carney complex. (18804312)
2008
23
Divergent myoid, neuroendocrine, and perineural differentiation in a nasal tumor of a patient with Carney complex. (18162785)
2008
24
Carney complex: pathology and molecular genetics. (17047382)
2006
25
A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. (15930266)
2005
26
Eyelid myxoma in Carney complex without PRKAR1A allelic loss. (15368482)
2004
27
Mutation of perinatal myosin heavy chain associated with a Carney complex variant. (15282353)
2004
28
Pathology and molecular genetics of the pituitary gland in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas' (Carney complex). (15281351)
2004
29
A mouse model for Carney complex. (15666843)
2004
30
Clinical and molecular genetics of Carney complex. (12666684)
2003
31
PRKAR1A gene mutations in two patients with myxoma syndrome (Carney complex)]. (12891303)
2003
32
Chromosome 2 (2p16) abnormalities in Carney complex tumours. (12676898)
2003
33
Pituitary adenoma in Carney complex: an immunohistochemical, ultrastructural, and immunoelectron microscopic study. (12537759)
2002
34
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the &quot;complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas&quot; (Carney complex). (12119264)
2002
35
Carney complex, a familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease: a case report. (12670039)
2002
36
Genetic alterations of Carney complex are not present in sporadic cardiac myxomas. (11744997)
2002
37
Protein kinase A in Carney complex: a new example of cAMP pathway alteration in endocrine tumors. (11248738)
2001
38
Images in Cardiology: Asymptomatic right atrial myxoma in acromegalic man: a case of Carney complex. (11119471)
2001
39
Pigmented vulvar macules as a presenting feature of the Carney complex. (11737445)
2001
40
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. (10973256)
2000
41
Epithelioid blue nevus occurring in children with no evidence of Carney complex. (10535581)
1999
42
Radiation hybrid mapping of chromosomal region 2p15-p16: integration of expressed and polymorphic sequences maps at the Carney complex (CNC) and Doyne honeycomb retinal dystrophy (DHRD) loci. (10087203)
1999
43
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex. (10084605)
1999
44
Characterization of the adrenal gland pathology of Carney complex, and molecular genetics of the disease. (9888588)
1998
45
Evidence for genetic heterogeneity of the Carney complex (familial atrial myxoma syndromes). (9797786)
1998
46
Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci. (9709978)
1998
47
Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex) (9215269)
1997
48
Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. (8609225)
1996
49
Psammomatous melanotic schwannoma of a spinal nerve root. Relationship with the Carney complex. (9122034)
1996
50
The Carney complex (myxomas, spotty pigmentation, endocrine overactivity, and schwannomas). (7712644)
1995

Genetic Variations for Carney Complex

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Carney Complex:

62
id Symbol AA change Variation ID SNP ID
1PRKAR1Ap.Ser9AsnVAR_046894
2PRKAR1Ap.Arg74CysVAR_046895
3PRKAR1Ap.Arg146SerVAR_046896
4PRKAR1Ap.Asp183TyrVAR_046897
5PRKAR1Ap.Ala213AspVAR_046898
6PRKAR1Ap.Gly289TrpVAR_046899

Expression for genes affiliated with Carney Complex

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carney Complex

Search GEO for disease gene expression data for Carney Complex.

Pathways for genes affiliated with Carney Complex

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 53Reactome, 49PharmGKB
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Pathways related to Carney Complex according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PRKAR2B, PRKAR1A, PRKAR2A
29.7PRKAR2A, PRKAR1A, PRKAR2B
39.7PRKAR2A, PRKAR1A, PRKAR2B
49.7PRKAR2B, PRKAR1A, PRKAR2A
59.7PRKAR2B, PRKAR1A, PRKAR2A
69.7PRKAR2A, PRKAR1A, PRKAR2B
7
Hide members
9.5AKT2, PRKAR2B, PRKAR1A, PRKAR2A
8
Development A3 receptor signaling
Hide members
9.5AKT2, PRKAR2B, PRKAR1A, PRKAR2A
9
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, AKT2
109.5PRKAR2A, PRKAR1A, PRKAR2B, AKT2
11
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GH1
129.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
13
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
14
Hide members
9.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
15
Hide members
9.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
16
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
17
Signal transduction cAMP signaling
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
18
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
9.5GNAS, PRKAR2B, PRKAR1A, PRKAR2A
19
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
209.5PRKAR2A, PRKAR1A, PRKAR2B, GNAS
21
Hide members
9.4MYH8, PRKAR2A, PRKAR1A, PRKAR2B, STK11
22
Development Leptin signaling via PI3K-dependent pathway
Hide members
9.4STK11, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
239.4STK11, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
24
Hide members
9.4STK11, GH1, PRKAR2B, PRKAR1A, PRKAR2A
25
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9.4GNAS, STK11, PRKAR2B, PRKAR1A, PRKAR2A
26
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9.3PRKAR2B, PRKAR1A, PRKAR2A, MYH8, PTEN
27
Hide members
9.3AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
28
Hide members
9.3AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
29
Hide members
9.3AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
30
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
31
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
32
Development A2B receptor- action via G-protein alpha s
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
33
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
34
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
35
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.3GNAS, AKT2, PRKAR2B, PRKAR1A, PRKAR2A
36
Hide members
9.3AKT2, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
37
Hide members
9.3PTEN, PRKAR2A, PRKAR1A, PRKAR2B, AKT2
38
Hide members
9.3GH1, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
39
Hide members
9.2AKT2, PRKAR2B, PRKAR1A, PRKAR2A, MYH8, PTEN
40
Hide members
9.2VHL, AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
41
Hide members
9.1AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
42
Hide members
9.1AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A, PTEN
43
Hide members
9.0AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A, MYH8
44
Translation Insulin regulation of translation
Hide members
9.0STK11, AKT2, GH1, PRKAR2B, PRKAR1A, PRKAR2A
45
Hide members
8.9PTEN, PRKAR2A, PRKAR1A, PRKAR2B, AKT2, GNAS
46
Hide members
8.9GNAS, PDE11A, AKT2, F13A1, PRKAR2B, PRKAR1A
47
Hide members
8.7VHL, STK11, AKT2, GH1, PRKAR2B, PRKAR1A
48
Hide members
8.4GNAS, PDE11A, STK11, MEN1, AKT2, GH1

Compounds for genes affiliated with Carney Complex

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Carney Complex according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7F13A1
2glucose4410.5PTEN, STK11
3smcc4410.4SYP, CHGA
4forskolin44 49 1112.4PRKAR1A, PRKAR2B
5111in-pentetreotide4410.4CHGA, SYP
6l-amino acid4410.3CHGA, SYP, PRKAR1A
7s 1004410.3F13A1, SYP, CHGA
8Cyclic Adenosine Monophosphate1110.3PRKAR1A, PRKAR2B
9b 7234410.3F13A1, SYP, CHGA
10octreotide44 59 28 1113.2GNAS, GH1, CHGA
11pka inhibitor fragment (6-22) amide5910.1PRKAR1A, PRKAR2B, PRKAR2A
12camps-sp, triethylammonium salt5910.1PRKAR2A, PRKAR1A, PRKAR2B
13pki 14-22 amide, myristoylated5910.1PRKAR2B, PRKAR1A, PRKAR2A
14h 89 dihydrochloride5910.1PRKAR2B, PRKAR1A, PRKAR2A
15reticulin4410.1SYP, F13A1
16silver4410.1CHGA, SYP, F13A1
17hematoxylin4410.1F13A1, SYP, CHGA, PTEN
18kt 572044 28 5912.1PRKAR2A, PRKAR1A, PRKAR2B
19acth4410.1CHGA, SYP, GH1, GNAS
20amine4410.0CHGA, SYP, F13A1
21guanine44 11 2412.0GNAS, STK11, GH1, SYP, CHGA
22histidine4410.0VHL, GNAS, SYP, CHGA
23vitamin d449.9MEN1, GH1, PRKAR1A, CHGA, PTEN
24tamoxifen44 49 28 1112.9AKT2, GH1, CHGA, PTEN
25adenylate449.8GNAS, STK11, GH1, PRKAR1A, CHGA
26glycogen44 2410.8VHL, STK11, AKT2, SYP, CHGA, PTEN
275-hydroxytryptophan449.8CHGA, GH1
28paraffin449.8STK11, GH1, F13A1, SYP, CHGA, PTEN
29norepinephrine44 11 2411.7GNAS, GH1, SYP, CHGA
30rapamycin449.7VHL, STK11, AKT2, PTEN
31progesterone44 59 28 11 2413.6GNAS, GH1, F13A1, SYP, CHGA, PTEN
32cysteine449.5GNAS, GH1, PRKAR1A, SYP, CHGA, PTEN
33steroid449.5GNAS, GH1, PRKAR1A, SYP, CHGA, ACBD3
34oligonucleotide449.5VHL, GNAS, AKT2, GH1, F13A1, CHGA
35lipid449.5GNAS, STK11, AKT2, GH1, SYP, CHGA
36vegf449.4VHL, STK11, MEN1, GH1, F13A1, SYP
37tyrosine449.3VHL, GNAS, MEN1, AKT2, GH1, SYP
38serine449.2VHL, GNAS, STK11, MEN1, AKT2, GH1
39calcium44 49 11 2412.2VHL, GNAS, STK11, MEN1, F13A1, PRKAR1A
40cyclic amp44 249.8PTEN, GNAS, PDE11A, STK11, PRKAR2B, PRKAR1A

GO Terms for genes affiliated with Carney Complex

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16Gene Ontology
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Cellular components related to Carney Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:03158810.0PRKAR2A, PRKAR1A
2cAMP-dependent protein kinase complexGO:0059529.6PRKAR2B, PRKAR1A, PRKAR2A
3protein complexGO:0432349.6SYP, PRKAR1A, MEN1, STK11
4cytosolGO:0058298.1PTEN, VHL, GNAS, PDE11A, STK11, MEN1

Biological processes related to Carney Complex according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1tissue homeostasisGO:00189410.1STK11, GNAS
2negative regulation of organ growthGO:04662110.1MEN1, PTEN
3negative regulation of cAMP-dependent protein kinase activityGO:200048010.0PRKAR2A, PRKAR1A, PRKAR2B
4activation of protein kinase A activityGO:0341999.9PRKAR2A, PRKAR1A, PRKAR2B
5cellular response to glucagon stimulusGO:0713779.8GNAS, PRKAR2B, PRKAR1A, PRKAR2A
6activation of phospholipase C activityGO:0072029.8PRKAR2A, PRKAR1A, PRKAR2B
7water transportGO:0068339.8GNAS, PRKAR2B, PRKAR1A, PRKAR2A
8regulation of insulin secretionGO:0507969.7GNAS, PRKAR2B, PRKAR1A, PRKAR2A
9energy reserve metabolic processGO:0061129.6PRKAR2A, PRKAR1A, PRKAR2B, STK11, GNAS
10fibroblast growth factor receptor signaling pathwayGO:0085439.6PTEN, PRKAR2A, PRKAR1A, PRKAR2B
11epidermal growth factor receptor signaling pathwayGO:0071739.6PRKAR2B, PRKAR1A, PRKAR2A, PTEN
12blood coagulationGO:0075969.2GNAS, PDE11A, F13A1, PRKAR2B, PRKAR1A, PRKAR2A
13neurotrophin TRK receptor signaling pathwayGO:0480119.2PTEN, PRKAR2A, PRKAR1A, PRKAR2B
14signal transductionGO:0071659.0PDE11A, AKT2, PRKAR2B, PRKAR1A, PRKAR2A, AIP

Molecular functions related to Carney Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP-dependent protein kinase regulator activityGO:0086039.7PRKAR2A, PRKAR1A, PRKAR2B
2cAMP-dependent protein kinase inhibitor activityGO:0048629.6PRKAR2B, PRKAR1A, PRKAR2A
3cAMP bindingGO:0305529.5PRKAR2A, PRKAR1A, PRKAR2B, PDE11A
4protein kinase A catalytic subunit bindingGO:0342369.4PRKAR2A, PRKAR1A, PRKAR2B

Products for genes affiliated with Carney Complex

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carney Complex

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet