Carney Triad disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Carney Triad

Sources:
⁴⁶OMIM, ³²MalaCards
See all sources

MalaCards based summary: Carney Triad, also known as gastric leiomyosarcoma, pulmonary chondroma, and extraadrenal paraganglioma, is related to gastrointestinal stromal tumor and paraganglioma and gastric stromal sarcoma, and has symptoms including diarrhea, nausea and vomiting and abdominal pain. An important gene associated with Carney Triad is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Sorafenib Pharmacodynamics and Striated Muscle Contraction. The compounds mibg and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include lung and lymph node, and related mouse phenotypes are behavior/neurological and muscle.

Description from OMIM:⁴⁶ 604287

Aliases & Classifications for Carney Triad

Sources:
⁴²NIH Rare Diseases, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁴⁶OMIM, ⁶¹UMLS, ²⁷ICD10 via Orphanet
See all sources

Carney Triad, Aliases & Descriptions:

Name: Carney Triad ⁴² ⁴⁴ ⁴⁸ ⁴⁶ ⁶¹

Gastric Leiomyosarcoma, Pulmonary Chondroma, and Extraadrenal Paraganglioma ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases, Gastrointestinal diseases

ICD10: ²⁷

Neoplasms

Neoplasms of uncertain or unknown behaviour

Neoplasm of uncertain or unknown behaviour of endocrine glands

Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement

Orphanet: ⁴⁸

Rare endocrine diseases

Rare tumors

Characteristics (Orphanet epidemiological data):

⁴⁸

carney triad:
Prevalence: <1/1000000; Age of onset: Adolescence / Young adulthood

External Ids:

OMIM⁴⁶ 604287

ICD10 via Orphanet²⁷ D44.8

Related Diseases for Carney Triad

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Carney Triad via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 88)

id	Related Disease	Score	Top Affiliating Genes
1	gastrointestinal stromal tumor	31.3	KIT, PDGFRA
2	paraganglioma and gastric stromal sarcoma	30.8	SDHC, SDHD, SDHB
3	pheochromocytoma	30.8	SDHD, SDHB
4	chondroma	30.8	SDHB, SDHD, SDHC, PDGFRA
5	paraganglioma	30.8	DES, SDHB, SDHD, ACTC1
6	neurofibromatosis	30.8	SDHD, SDHB
7	adrenal cortical adenoma	30.6	SDHB, SDHD, SDHC
8	sarcoma	30.3	KIT, PDGFRA, ACTC1, DES
9	leiomyoma	30.0	DES, ACTC1, PDGFRA, KIT
10	leiomyomatosis	10.5	SDHB
11	infantile myofibromatosis	10.4	DES
12	myelofibrosis	10.4	PDGFRA
13	ductal carcinoma in situ	10.4	PDPN
14	fasciitis	10.4	ACTC1
15	familial colorectal cancer	10.3	SDHD, SDHB
16	paragangliomas 5	10.3	SDHA
17	liposarcoma	10.3	DES
18	kidney cancer	10.3	PDPN
19	mesenchymal cell neoplasm	10.3	PDGFRA, KIT
20	piebaldism	10.3	KIT, PDGFRA
21	systemic mastocytosis	10.3	PDGFRA, KIT
22	hypereosinophilic syndrome	10.2	PDGFRA, KIT
23	pdgfrb-associated chronic eosinophilic leukemia	10.2	PDGFRA, KIT
24	hereditary paraganglioma-pheochromocytoma syndromes	10.2	SDHC, SDHD, SDHB
25	dedifferentiated liposarcoma	10.2	DES, KIT
26	mastocytosis	10.2	KIT, PDGFRA
27	carotid body tumor	10.2	SDHB, SDHD, SDHC
28	uterine sarcoma	10.2	KIT, DES
29	phaeochromocytoma	10.2	SDHC, SDHD, SDHB
30	multiple endocrine neoplasia type 2a	10.2	SDHB, SDHD, SDHC
31	von hippel-lindau disease	10.2	SDHB, SDHD, SDHC
32	malignant peripheral nerve sheath tumor	10.2	PDGFRA, KIT
33	multiple endocrine neoplasia	10.2	SDHB, SDHD, SDHC
34	germinoma	10.2	KIT, PDPN
35	wermer syndrome	10.2	SDHB, SDHD, SDHC
36	hyperparathyroidism	10.2	SDHB, SDHD, SDHC
37	chordoma	10.2	PDGFRA, DES
38	polycythemia vera	10.2	KIT, PDGFRA
39	adenosarcoma	10.2	ACTC1, DES
40	hepatitis	10.2
41	adenoma	10.2
42	harlequin syndrome	10.2
43	paragangliomas 1, with or without deafness	10.2
44	epithelioid leiomyosarcoma	10.2	DES, ACTC1
45	pseudosarcomatous fibromatosis	10.2	DES, ACTC1
46	spindle cell carcinoma	10.2	ACTC1, DES
47	spindle cell sarcoma	10.2	DES, ACTC1
48	cutaneous fibrous histiocytoma	10.2	ACTC1, DES
49	lymphangioma	10.1	ACTC1, PDPN
50	fibrous histiocytoma	10.1	DES, ACTC1

Graphical network of the top 20 diseases related to Carney Triad:

Symptoms for Carney Triad

Sources:
⁴⁶OMIM, ⁵⁸The Human Phenotype Ontology, ⁴⁸Orphanet
See all sources

Clinical features from OMIM:

604287

Symptoms:

⁴⁸ (show all 21)

nausea/vomiting/regurgitation/merycism/hyperemesis
acute abdominal pain/colic
acute diarrhea
gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
neoplasms/tumors
estomach/gastric neoplasm/tumor/carcinoma/cancer
lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
pheochromocytoma/paraganglioma
sarcoma
asthenia/fatigue/weakness
ascitis

hepatitis/icterus/cholestasis
ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
mediastinal anomalies
cortico-adrenal hyperplasia/hypersecretion
cardiac rhythm disorder/arrhythmia
chronic arterial hypertension
lymphadenopathy/polyadenopathies
facial pain/cephalalgia/migraine
anorexia
anaemia

HPO human phenotypes related to Carney Triad:

(show all 17)

id	Description	Frequency	HPO Source Accession
1	diarrhea	hallmark (90%)	HP:0002014
2	nausea and vomiting	hallmark (90%)	HP:0002017
3	abdominal pain	hallmark (90%)	HP:0002027
4	gastrointestinal hemorrhage	hallmark (90%)	HP:0002239
5	neoplasm of the stomach	hallmark (90%)	HP:0006753
6	sarcoma	hallmark (90%)	HP:0100242
7	neoplasm of the lung	hallmark (90%)	HP:0100526
8	neuroendocrine neoplasm	hallmark (90%)	HP:0100634
9	abnormality of the liver	typical (50%)	HP:0001392
10	ascites	typical (50%)	HP:0001541
11	hypercortisolism	typical (50%)	HP:0001578
12	mediastinal lymphadenopathy	typical (50%)	HP:0100721
13	hypertension	occasional (7.5%)	HP:0000822
14	anemia	occasional (7.5%)	HP:0001903
15	anorexia	occasional (7.5%)	HP:0002039
16	migraine	occasional (7.5%)	HP:0002076
17	arrhythmia	occasional (7.5%)	HP:0011675

Drugs & Therapeutics for Carney Triad

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Carney Triad

Search NIH Clinical Center for Carney Triad

Genetic Tests for Carney Triad

Anatomical Context for Carney Triad

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Carney Triad:

³²

Lung, Lymph node

Animal Models for Carney Triad or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Carney Triad:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	7.9	KIT, PDPN, PDGFRA, SDHD, DES
2	muscle phenotype	MP:0005369	7.6	DES, ACTC1, PDGFRA, PDPN, KIT
3	cardiovascular system phenotype	MP:0005385	7.5	KIT, PDPN, PDGFRA, ACTC1, SDHD, DES
4	homeostasis/metabolism phenotype	MP:0005376	7.1	DES, SDHD, ACTC1, PDGFRA, PDPN, KIT
5	mortality/aging	MP:0010768	7.0	DES, SDHD, SDHC, ACTC1, PDGFRA, PDPN

Publications for Carney Triad

Sources:
⁵¹PubMed
See all sources

Articles related to Carney Triad:

(show all 37)

id	Title	Authors	Year
1	Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad. (24859990)	Haller F.... Agaimy A.	2014
2	Carney triad. (23652673)	Carney J.A.	2013
3	Adrenal cortical adenoma: the fourth component of the Carney triad and an association with subclinical Cushing syndrome. (23681078)	Carney J.A.... Young W.F.	2013
4	Hepatic paraganglioma and multifocal gastrointestinal stromal tumor in a female: Incomplete Carney triad. (23894692)	Hong S.W.... Lee H.K.	2013
5	First report of harlequin syndrome as the presenting feature of Carney Triad: a diagnostic and imaging challenge. (22689797)	TaA^eb D.... Mundler O.	2012
6	Two out of three required: a case of incomplete Carney triad. (21791484)	Slevin F.... Sherlock D.	2012
7	Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triad. (21663639)	Otto C.... Haller F.	2011
8	Images of a case of Carney triad by combined F-18 FDG PET/CT. (21716025)	Kato K.... Naganawa S.	2011
9	SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors. (20890271)	Gaal J.... de Krijger R.R.	2011
10	Multicentric paragangliomas associated with Carney triad. (20336905)	Kiser M.... von Allmen D.	2010
11	Images for diagnosis. An unusual case of Carney triad with high level catecholamine-secreting but no existence of extra-adrenal paraganglioma. (20193497)	Qiao G.B.... Huang W.J.	2010
12	Lymphatics and D2-40/podoplanin expression in gastrointestinal stromal tumours of the stomach with and without lymph node metastasis: an immunohistochemical study with special reference to the Carney triad. (20203222)	Agaimy A.... Carney J.A.	2010
13	Clinical, radiologic and pathologic characteristics of the Carney triad: a case report and literature review. (20705254)	Chen C.F.... Hsieh J.S.	2010
14	Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. (19935059)	Zhang L.... Carney J.A.	2010
15	Carney triad versus Carney Stratakis syndrome: two cases which illustrate the difficulty in distinguishing between these conditions in individual patients. (20119652)	Alrashdi I.... Hodgson S.V.	2010
16	Incomplete Carney triad--a review of two cases. (19561114)	Sawhney S.A.... Dempsey O.J.	2009
17	Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. (19723753)	Carney J.A.	2009
18	Carney triad in an adult with aggressive behavior: the first case in Korea. (19881977)	Song H.J.... Park C.K.	2009
19	The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. (19522824)	Stratakis C.A.... Carney J.A.	2009
20	Multiple pulmonary chondromas in a young female patient: a component of Carney triad. (19461402)	Qiao G.B.... Wu Y.L.	2009
21	Respiratory symptoms in a boy revealing Carney triad. (17039489)	Delemarre L.... Verschuur A.	2008
22	Answer to case of the month # 131. Carney triad. (18533398)	Colapinto M.N.... Weiser W.J.	2008
23	A calcified lung tumour and microcytic anaemia in a young woman: partial expression of the Carney triad. (18697369)	Alberto V.O.... Carney J.A.	2008
24	Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma. (18043038)	Rodriguez F.J.... Carney J.A.	2007
25	Genetics of carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. (17535989)	Matyakhina L.... Stratakis C.A.	2007
26	Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization. (17549339)	Agaimy A.... Schneider-Stock R.	2007
27	Use of 2-tracer PET to diagnose gastrointestinal stromal tumour and pheochromocytoma in patients with Carney triad and neurofibromatosis type 1. (16638708)	BA1mming P.... Ahlman H.	2006
28	A new case of Carney triad: gastrointestinal stromal tumours and leiomyoma of the oesophagus do not show activating mutations of KIT and platelet-derived growth factor receptor alpha. (17021135)	Knop S.... Kroeber S.M.	2006
29	Interventional radiology in Carney triad. (15108016)	Vogl T.J.... Wurster M.G.	2005
30	Dual CD117 expression in gastrointestinal stromal tumor (GIST) and paraganglioma of Carney triad: a case report. (15735861)	Horenstein M.G.... Tucker J.A.	2005
31	Carney triad: case report and molecular analysis of gastric tumor. (15712189)	Diment J.... Colecchia M.	2005
32	Getting the GIST of the Carney Triad: growth factors, rare tumors, and cellular respiration. (15383926)	Amieux P.S.	2004
33	Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triad. (11857563)	Carney J.A.... Stratakis C.A.	2002
34	A case of the Carney triad. (15251665)	Jabbour S.A.... Miller J.L.	1999
35	The Carney Triad: a lesson in observation, creativity, and perseverance. (10377941)	Appelman H.D.	1999
36	Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence. (10377927)	Carney J.A.	1999
37	Neuroectodermal differentiation of the gastrointestinal tumors in the Carney triad. An ultrastructural and immunohistochemical study. (8317611)	Perez-Atayde A.R.... Kozakewich H.W.	1993

Genes related to Carney Triad

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Carney Triad:

- Elite gene

id	Symbol	Description	Score	Implication
1	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	21.23	GeneCards inferred via : Publications, Disorders (show sections)
2	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	19.00	GeneCards inferred via : Publications, Disorders (show sections)
3	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	16.78	GeneCards inferred via : Publications, Disorders (show sections)
4	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	14.56	GeneCards inferred via : Publications, Disorders (show sections)
5	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	12.34	GeneCards inferred via : Publications, Disorders (show sections)
6	ACTC1	actin, alpha, cardiac muscle 1	10.06	GeneCards inferred via : Publications (show sections)
7	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	7.84	GeneCards inferred via : Publications (show sections)
8	DES	desmin	5.61	GeneCards inferred via : Publications (show sections)
9	PDPN	podoplanin	3.39	GeneCards inferred via : Publications (show sections)

Products for genes related to Carney Triad disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	9	-	9	9
2	Novus Biologicals	8	9	9	-

Variations for Carney Triad

Expression for genes affiliated with Carney Triad

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Carney Triad

Search GEO for disease gene expression data for Carney Triad.

Pathways for genes affiliated with Carney Triad

Sources:
⁴⁹PathCards, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ³⁰KEGG, ⁵Cell Signaling Technology
See all sources

Pathways related to Carney Triad according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Sorafenib Pharmacodynamics⁵⁰ Show member pathways VEGF Pathway⁶⁰ Vemurafenib Pathway, Pharmacodynamics⁵⁰	9.6	KIT, PDGFRA
2	Striated Muscle Contraction³⁷ Show member pathways Smooth Muscle Contraction⁵⁴ Muscle contraction⁵⁴ Striated Muscle Contraction⁵⁴	9.1	ACTC1, DES
3	Cardiac Progenitor Differentiation³⁷	9.1	ACTC1, PDGFRA, KIT
4	Carbon metabolism³⁰ Show member pathways Valine, leucine and isoleucine biosynthesis³⁰ Biosynthesis of amino acids³⁰ Pentose Phosphate Pathway (Erythrocyte)⁵⁰ L-serine degradation³⁷ pentose phosphate pathway (oxidative branch)³⁷ 2-Oxocarboxylic acid metabolism³⁰ formaldehyde oxidation II (glutathione-dependent)³⁷	8.8	SDHB, SDHD, SDHC, SDHA
5	Alzheimer's disease³⁰ Show member pathways Alzheimers Disease³⁷	8.8	SDHA, SDHC, SDHD, SDHB
6	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.⁵⁴ Show member pathways Formation of ATP by chemiosmotic coupling⁵⁴ Oxidative phosphorylation³⁰ The citric acid (TCA) cycle and respiratory electron transport⁵⁴ Respiratory electron transport⁵⁴ Oxidative phosphorylation³⁷ Electron Transport Chain³⁷ Non-alcoholic fatty liver disease (NAFLD)³⁰ Huntington's disease³⁰ Parkinson's disease³⁰	8.8	SDHA, SDHC, SDHD, SDHB
7	Citric acid cycle (TCA cycle)⁵⁴ Show member pathways TCA cycle³⁷ pyruvate decarboxylation to acetyl CoA³⁷ Pyruvate metabolism⁵⁴ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate⁵⁴ Regulation of pyruvate dehydrogenase (PDH) complex⁵⁴ Citrate cycle (TCA cycle)³⁰ NAD phosphorylation and dephosphorylation³⁷ Pyruvate metabolism and Citric Acid (TCA) cycle⁵⁴ TCA Cycle³⁷ conversion of glucose to acetyl CoA and entry into the TCA cycle³⁷	8.8	SDHA, SDHC, SDHD, SDHB
8	Cytoskeletal Signaling⁵	8.6	DES, ACTC1, PDPN

Compounds for genes affiliated with Carney Triad

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁵⁰PharmGKB, ²⁵HMDB, ²⁹IUPHAR, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Carney Triad according to GeneCards/GeneDecks:

(show all 46)

id	Compound	Score	Top Affiliating Genes
1	mibg⁴⁴	10.1	SDHD, SDHB
2	pkc 412⁴⁴	9.9	PDGFRA, KIT
3	ag-1296⁴⁴	9.9	PDGFRA, KIT
4	thenoyltrifluoroacetone⁴⁴ ¹²	10.9	SDHB, SDHA
5	fumarate⁴⁴ ¹²	10.8	SDHC, SDHD, SDHB
6	pazopanib⁵⁰ ¹²	10.8	PDGFRA, KIT
7	Ubiquinol 8²⁵	9.8	SDHB, SDHA
8	ponatinib⁵⁰ ¹²	10.8	KIT, PDGFRA
9	sunitinib⁴⁴ ⁵⁰ ¹²	11.8	KIT, PDGFRA
10	regorafenib⁵⁰ ¹²	10.8	KIT, PDGFRA
11	orcein⁴⁴	9.5	DES, ACTC1
12	toluidine⁴⁴	9.5	KIT, DES
13	s 100⁴⁴	9.5	DES, ACTC1
14	reticulin⁴⁴	9.4	DES, ACTC1
15	mucicarmine⁴⁴	9.4	ACTC1, DES
16	Fumaric acid²⁵	9.3	SDHA, SDHC, SDHD, SDHB
17	succinic acid²⁹ ²⁵ ¹²	11.3	SDHB, SDHD, SDHC, SDHA
18	iron-sulfur⁴⁴	9.2	SDHB, SDHD, SDHC, SDHA
19	ubiquinone⁴⁴	9.2	SDHB, SDHD, SDHC, SDHA
20	Sulfide²⁵	9.2	SDHB, SDHD, SDHC, SDHA
21	QH2²⁵	9.2	SDHA, SDHC, SDHD, SDHB
22	Ubiquinone Q2²⁵	9.2	SDHB, SDHD, SDHC, SDHA
23	Ubiquinone Q1²⁵	9.2	SDHA, SDHC, SDHD, SDHB
24	succinate⁴⁴	9.2	SDHB, SDHD, SDHC, SDHA
25	FAD²⁵	9.2	SDHB, SDHD, SDHC, SDHA
26	nad+⁴⁴	9.0	SDHA, SDHB, DES
27	gold⁴⁴	9.0	KIT, PDPN, DES
28	formaldehyde⁴⁴ ²⁵	10.0	KIT, ACTC1, DES
29	b 723⁴⁴	9.0	PDPN, ACTC1, DES
30	creatinine⁴⁴	8.8	ACTC1, SDHB, DES
31	lactate⁴⁴	8.8	KIT, SDHB, DES
32	glycogen⁴⁴ ²⁵	9.7	KIT, ACTC1, SDHB, DES
33	imatinib⁴⁴ ⁵⁰ ¹²	10.7	DES, ACTC1, PDGFRA, KIT
34	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.6	KIT, ACTC1, SDHB, DES
35	hematoxylin⁴⁴	8.6	DES, ACTC1, PDPN, KIT
36	steroid⁴⁴	8.5	DES, SDHC, ACTC1, KIT
37	thymidine⁴⁴ ²⁵	9.5	DES, PDGFRA, KIT
38	glucose⁴⁴	8.4	KIT, ACTC1, SDHB, DES
39	estrogen⁴⁴	8.4	DES, ACTC1, PDGFRA, KIT
40	retinoic acid⁴⁴ ²⁵	9.3	DES, SDHC, ACTC1, PDGFRA, KIT
41	paraffin⁴⁴	8.2	DES, ACTC1, PDGFRA, PDPN, KIT
42	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	10.9	DES, SDHB, ACTC1, PDGFRA, KIT
43	iron⁴⁴ ²⁵	8.9	DES, SDHB, SDHD, SDHC, SDHA, ACTC1
44	oxygen⁴⁴ ²⁵	8.9	DES, SDHB, SDHD, SDHC, SDHA, ACTC1
45	tyrosine⁴⁴	7.8	DES, SDHB, ACTC1, PDGFRA, PDPN, KIT
46	vegf⁴⁴	7.5	DES, SDHB, SDHC, ACTC1, PDGFRA, PDPN

GO Terms for genes affiliated with Carney Triad

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Carney Triad according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II	GO:005749	8.8	SDHA, SDHC, SDHD, SDHB
2	mitochondrion	GO:005739	8.8	SDHA, SDHC, SDHD, SDHB
3	external side of plasma membrane	GO:009897	8.8	KIT, PDPN, PDGFRA
4	mitochondrial inner membrane	GO:005743	8.7	SDHB, SDHD, SDHC, SDHA

Biological processes related to Carney Triad according to GeneCards/GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	aerobic respiration	GO:009060	9.8	SDHC, SDHB
2	positive regulation of phospholipase C activity	GO:010863	9.8	KIT, PDGFRA
3	succinate metabolic process	GO:006105	9.7	SDHB, SDHA
4	cardiac myofibril assembly	GO:055003	9.7	PDGFRA, ACTC1
5	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.6	PDGFRA, KIT
6	positive regulation of phosphatidylinositol 3-kinase signaling	GO:014068	9.6	KIT, PDGFRA
7	cell chemotaxis	GO:060326	9.3	KIT, PDGFRA
8	positive regulation of cell migration	GO:030335	9.2	KIT, PDPN, PDGFRA
9	tricarboxylic acid cycle	GO:006099	9.1	SDHA, SDHC, SDHD, SDHB
10	respiratory electron transport chain	GO:022904	9.1	SDHB, SDHD, SDHC, SDHA
11	cellular metabolic process	GO:044237	9.0	SDHA, SDHC, SDHD, SDHB
12	muscle filament sliding	GO:030049	9.0	ACTC1, DES

Molecular functions related to Carney Triad according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:048039	9.7	SDHB, SDHD
2	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.6	KIT, PDGFRA
3	succinate dehydrogenase (ubiquinone) activity	GO:008177	9.5	SDHA, SDHB
4	succinate dehydrogenase activity	GO:000104	9.2	SDHA, SDHC, SDHD
5	electron carrier activity	GO:009055	9.1	SDHC, SDHD, SDHB