MCID: CRT016
MIFTS: 57

Carotid Artery Disease malady

Categories: Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Carotid Artery Disease

Aliases & Descriptions for Carotid Artery Disease:

Name: Carotid Artery Disease 12 41 14
Carotid Artery Diseases 52 42 69
Disorder of Carotid Artery 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:3407
MeSH 42 D002340
NCIt 47 C84476
SNOMED-CT 64 371160000
ICD10 33 G45.1
UMLS 69 C0007273

Summaries for Carotid Artery Disease

MedlinePlus : 41 your carotid arteries are two large blood vessels in your neck. they supply your brain with blood. if you have carotid artery disease, the arteries become narrow, usually because of atherosclerosis. this is the buildup of cholesterol and other material in an artery. if a blood clot sticks in the narrowed arteries, blood can't reach your brain. this is one of the causes of stroke. carotid artery disease often does not cause symptoms, but there are tests that can tell your doctor if you have it. if the arteries are very narrow, you may need an operation called an endarterectomy to remove the plaque. for less severe narrowing, a medicine to prevent blood clots can reduce your risk of stroke. another option for people who can't have surgery is carotid angioplasty. this involves placing balloons and/or stents into the artery to open it and hold it open.

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to myocardial infarction and atherosclerosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Carotid Artery Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Lipoprotein metabolism and Cell surface interactions at the vascular wall. The drugs Cilostazol and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Related Diseases for Carotid Artery Disease

Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 27.9 ACE APOA1 APOB APOE CCL2 COG2
2 atherosclerosis 11.2
3 artery disease 10.9
4 cerebritis 10.3
5 zap-70 deficiency 10.3 APOB APOE
6 keratoconus 4 10.3 APOB APOE
7 lupus erythematosus panniculitis 10.3 ACE APOE
8 alzheimer disease 19, late onset 10.3 APOB APOE LPA
9 familial progressive cardiac conduction defect 10.2 APOA1 APOE
10 spinocerebellar ataxia 20 10.2 APOA1 APOB LPA
11 anaplastic ganglioglioma 10.2 APOA1 CRP LPA
12 primary pigmented nodular adrenocortical disease 10.2 APOA1 APOB APOE
13 iron metabolism disease 10.2 ACE APOE CRP
14 diffuse large b-cell lymphoma 10.2 CRP MMP1 MMP9
15 mannosidosis, beta 10.2 APOA1 APOB APOE
16 malignant hyperthermia susceptibility 1 10.2 ACE APOB LPA
17 hyperlucent lung 10.2 CCL2 CRP MMP9
18 cataract 5, multiple types 10.2 APOA1 APOB APOE
19 asphyxia neonatorum 10.2 ACE APOE LPA
20 pars planitis 10.2 ACE APOA1 APOE
21 dyserythropoietic anemia, congenital, type ii 10.2 APOA1 APOE LPA
22 kleptomania 10.2 MMP1 MMP9
23 dentinogenesis imperfecta type 2 10.2 APOB APOE
24 congenital hypomyelination neuropathy 10.2 MMP9 TIMP1
25 familial nephrotic syndrome 10.2 ACE APOB CRP
26 chordoid meningioma 10.2 CRP MMP9 TIMP1
27 limb ischemia 10.2 ACE APOE CRP
28 choroiditis 10.2 ACE CCL2 CRP
29 albinism, oculocutaneous, type v 10.2 APOA1 APOB APOE LPA
30 xerophthalmia 10.2 CRP MMP1 TIMP1
31 diabetic encephalopathy 10.2 ACE APOE CRP
32 bird fancier's lung 10.2 APOA1 APOB APOE LPA
33 chondrocalcinosis with early-onset osteoarthritis 10.2 APOA1 APOB APOE LPA
34 laryngostenosis 10.2 ACE MMP1 MMP9
35 von willebrand disease, platelet-type 10.2 APOA1 APOB APOE LPA
36 neuropathy, hereditary sensory and autonomic, type ia 10.2 APOA1 APOB APOE LPA
37 hypertriglyceridemia 10.2 APOA1 APOB APOE LPA
38 hyperlipoproteinemia type iv 10.1 APOB COG2 CRP
39 nodular cutaneous amyloidosis 10.1 MMP1 MMP9 TIMP1
40 urethral intrinsic sphincter deficiency 10.1 CCL2 MMP9 SELE
41 breast abscess 10.1 MMP1 MMP9 TIMP1
42 pulmonary eosinophilia 10.1 CCL2 CRP MMP9
43 focal dystonia 10.1 ACE APOB CCL2 CRP
44 neurofibroma of the heart 10.1 APOE CCL2 THBD
45 neonatal jaundice 10.1 CCL2 MMP9 TIMP1
46 adult-onset distal myopathy due to vcp mutation 10.1 MMP1 MMP9
47 acute chest syndrome 10.1 ACE CCL2 CRP MMP9
48 bare lymphocyte syndrome, type i 10.1 CCL2 CRP SELE
49 central nervous system teratoma 10.1 APOE MMP1 MMP9 TIMP1
50 neonatal diabetes mellitus 10.1 CCL2 SELE THBD

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease

Symptoms & Phenotypes for Carotid Artery Disease

UMLS symptoms related to Carotid Artery Disease:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ACE APOA1 APOB APOE CD163 COG2
2 cardiovascular system MP:0005385 10 ACE APOA1 APOB APOE CD163 CRP
3 immune system MP:0005387 9.77 THBD TIMP1 TNFSF4 ACE APOB APOE
4 liver/biliary system MP:0005370 9.17 ACE APOA1 APOB APOE SELE SLC39A2

Drugs & Therapeutics for Carotid Artery Disease

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 517)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved Phase 4 73963-72-1 2754
2
Simvastatin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 79902-63-9 54454
3
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
4
Ezetimibe Approved Phase 4,Phase 3,Phase 1,Early Phase 1 163222-33-1 150311
5
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
6
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
7
Zinc Approved Phase 4 7440-66-6 32051 23994
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
9
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
10
Nimodipine Approved Phase 4 66085-59-4 4497
11
Fluvastatin Approved Phase 4,Phase 3 93957-54-1 1548972
12
Methyltestosterone Approved Phase 4 58-18-4 6010
13
Testosterone Approved, Investigational Phase 4 58-22-0 6013
14
Enalapril Approved, Vet_approved Phase 4,Phase 2 75847-73-3 5362032 40466924
15
Enalaprilat Approved Phase 4,Phase 2 76420-72-9 6917719
16
Rimonabant Approved, Investigational Phase 4,Phase 3 168273-06-1, 158681-13-1 104850
17
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
18
Bosentan Approved, Investigational Phase 4,Phase 2 147536-97-8 104865
19
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-28-2 5757 53477783
20
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
21
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3 58-93-5 3639
22
Olmesartan Approved, Investigational Phase 4,Phase 3 144689-24-7, 144689-63-4 158781 130881
23
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
24
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 772 46507594
25 Nadroparin Approved Phase 4 9041-08-1
26
Nebivolol Approved, Investigational Phase 4,Phase 3 152520-56-4, 99200-09-6, 118457-14-0 71301
27
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
28
Warfarin Approved Phase 4,Phase 3 81-81-2 6691 54678486
29
Losartan Approved Phase 4,Phase 3,Phase 2 114798-26-4 3961
30
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
31
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
32
Probucol Approved Phase 4 23288-49-5 4912
33
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
34
Remifentanil Approved Phase 4 132875-61-7 60815
35
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
36
Acetaminophen Approved Phase 4 103-90-2 1983
37
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
38
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 3 37350-58-6, 51384-51-1 4171
39
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
40
Ticagrelor Approved Phase 4,Phase 3,Phase 2 274693-27-5 9871419
41
Insulin Aspart Approved Phase 4 116094-23-6 16132418
42
Insulin Detemir Approved Phase 4 169148-63-4 5311023
43
Valsartan Approved, Investigational Phase 4,Phase 2 137862-53-4 60846
44
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
45
Glimepiride Approved Phase 4,Phase 3,Phase 2 93479-97-1 3476
46
Drospirenone Approved Phase 4 67392-87-4 68873
47
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
48
Atenolol Approved Phase 4,Phase 3,Phase 2 29122-68-7 2249
49
Bisoprolol Approved Phase 4 66722-44-9 2405
50
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534

Interventional clinical trials:

(show top 50) (show all 861)
id Name Status NCT ID Phase
1 SAPPHIRE Worldwide: Stenting and Angioplasty With Protection in Patients At High-Risk for Endarterectomy Unknown status NCT00403078 Phase 4
2 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
3 Carotid Artery Stenting With Cilostazol Addition for Restenosis Unknown status NCT01261234 Phase 4
4 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4
5 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4
6 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4
7 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Unknown status NCT00772278 Phase 4
8 Effect of Statins on the Radial Intima-media Thickness After Transradial Angioplasty Unknown status NCT00952770 Phase 4
9 Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume Unknown status NCT01382277 Phase 4
10 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4
11 Homocysteine Lowering and Atherosclerosis Reduction Trial (HART) Unknown status NCT00217178 Phase 4
12 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4
13 Cilostazol Versus Aspirin for Primary Prevention of Atherosclerotic Events Unknown status NCT00886574 Phase 4
14 Nimodipine for Treating Acute Massive Cerebral Infarction Unknown status NCT02248233 Phase 4
15 Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization Unknown status NCT01029938 Phase 4
16 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4
17 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4
18 Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status NCT00734123 Phase 4
19 Testosterone Replacement in Older Men and Atherosclerosis Progression Unknown status NCT00287586 Phase 4
20 Amlodipine Plus/Minus Atorvastatin for Protection of Arteries Unknown status NCT01922687 Phase 4
21 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4
22 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4
23 Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging Unknown status NCT00920101 Phase 4
24 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4
25 Telmisartan, Amlodipine and Flow Mediated Dilation Unknown status NCT01180205 Phase 4
26 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4
27 Rosuvastatin Evaluation of Atherosclerotic Chinese Patients (REACH) Unknown status NCT00885872 Phase 4
28 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
29 Carotid Revascularization With ev3 Arterial Technology Evolution Post Approval Study Completed NCT00530504 Phase 4
30 A Carotid Stenting Boston Scientific Surveillance Program Completed NCT00741091 Phase 4
31 CAPTURE 2 Post-Marketing Registry Completed NCT00302237 Phase 4
32 CHOICE: Carotid Stenting For High Surgical-Risk Patients Completed NCT00406055 Phase 4
33 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
34 Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. Completed NCT00307307 Phase 4
35 Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study Completed NCT00723307 Phase 4
36 The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Completed NCT01341730 Phase 4
37 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT) Completed NCT01203982 Phase 4
38 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4
39 The Effects of an Intensive Lifestyle Modification Program on Carotid Artery Intima-Media Thickness Completed NCT00243581 Phase 4
40 Investigate Effect on Mean IMT of Probucol And/or CilosTazol in Patients With Coronary Heart dIsease Taking HMGCoA Reductase Inhibitor Therapy Completed NCT01291641 Phase 4
41 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4
42 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4
43 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4
44 A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) Completed NCT02596048 Phase 4
45 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4
46 Vasomotor Reactivity In Cerebral Small Vessel Disease And New Approach To Treat Lacunar Stroke Completed NCT00163150 Phase 4
47 Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY) Completed NCT00295191 Phase 4
48 Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression Completed NCT01212900 Phase 4
49 Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients Completed NCT01250405 Phase 4
50 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

Genetic Tests for Carotid Artery Disease

Genetic tests related to Carotid Artery Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Carotid Arteries 29

Anatomical Context for Carotid Artery Disease

MalaCards organs/tissues related to Carotid Artery Disease:

39
Testes, Brain, Heart, Endothelial, T Cells, Smooth Muscle, Caudate Nucleus

Publications for Carotid Artery Disease

Articles related to Carotid Artery Disease:

(show top 50) (show all 564)
id Title Authors Year
1
Biobanking in carotid artery disease: translation to clinical practice. ( 28051291 )
2017
2
Endovascular prevention and treatment of stroke related to extracranial carotid artery disease. ( 27922251 )
2017
3
Initial experience with the inspire MD C-Guard stent in the treatment of carotid artery disease. ( 27094426 )
2016
4
Carotid artery disease progression and related neurologic events after carotid endarterectomy. ( 27021378 )
2016
5
Extracranial Carotid Artery Disease: Risk Factors and Outcomes in Patients With Acute Critical Hemispheric Ischemic Stroke. ( 26764275 )
2016
6
Lesion Topography and Microscopic White Matter Tract Damage Contribute to Cognitive Impairment in Symptomatic Carotid Artery Disease. ( 27598537 )
2016
7
Additional value of inflammatory biomarkers and carotid artery disease in prediction of significant coronary artery disease as assessed by coronary computed tomography angiography. ( 27742738 )
2016
8
Multi-parametric ultrasound criteria for internal carotid artery disease-comparison with CT angiography. ( 27230916 )
2016
9
Neurocognitive Improvement in Patients Undergoing Carotid Endarterectomy for Atherosclerotic Occlusive Carotid Artery Disease. ( 28018503 )
2016
10
Prevalence of Carotid Artery Disease among Ambulatory Patients with Coronary Artery Disease. ( 26979002 )
2016
11
Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease. ( 26799121 )
2016
12
Lower extremity and carotid artery disease in COPD. ( 28053972 )
2016
13
Surgical Versus Percutaneous Therapy of Carotid Artery Disease: An Evidence-Based Outcomes Analysis. ( 27712968 )
2016
14
White Matter Diffusion Abnormalities in Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 27079165 )
2016
15
Cerebrovascular reactivity in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery disease. ( 27743788 )
2016
16
Atherosclerotic Plaque Composition Is Still an Almost Unrecognized Factor of Risk Stratification in Patients with Carotid Artery Disease. ( 26417182 )
2015
17
Screening for Peripheral Arterial Disease and Carotid Artery Disease in Patients With Abdominal Aortic Aneurysm. ( 26056393 )
2015
18
Subclinical carotid artery disease and plasma homocysteine levels in patients with hypertension. ( 25660367 )
2015
19
An unexpected full neurological recovery after cardiac arrest in a sickle cell anemia patient with bilateral cervical carotid artery disease. ( 26190434 )
2015
20
Management of extracranial carotid artery disease. ( 25439328 )
2015
21
Optimal treatment of extracranial carotid artery disease: carotid endarterectomy, carotid stenting, or optimal medical therapy. ( 26277363 )
2015
22
Carotid artery disease after head and neck radiotherapy. ( 25537055 )
2015
23
Teaching NeuroImages: Radiation-associated symptomatic carotid artery disease with ipsilateral radiodermatitis. ( 25646279 )
2015
24
Cortical ischemic lesion burden measured by DIR is related to carotid artery disease severity. ( 25547043 )
2015
25
Carotid artery disease in patients with type 2 diabetes. ( 26355919 )
2015
26
Progression of carotid-artery disease in type 2 diabetic patients: a cohort prospective study. ( 26527880 )
2015
27
Stroke prevention in asymptomatic carotid artery disease: revascularization of carotid stenosis is not the solution. ( 25883075 )
2015
28
Asymptomatic carotid artery disease: A personalized approach to management. ( 26651895 )
2015
29
Life-threatening coronary disease is prevalent in patients with stenosing carotid artery disease. ( 26311319 )
2015
30
Initial clinical experience with the micromesh roadsaver carotid artery stent for the treatment of patients with symptomatic carotid artery disease. ( 25809366 )
2015
31
Regarding "Subclinical carotid artery disease and plasma homocysteine levels in patients with hypertension". ( 25979414 )
2015
32
No Evidence for Retinal Damage Evolving from Reduced Retinal Blood Flow in Carotid Artery Disease. ( 26558275 )
2015
33
The Effects of Near-Infrared Spectroscopy on the Neurocognitive Functions in the Patients Undergoing Coronary Artery Bypass Grafting with Asymptomatic Carotid Artery Disease: A Randomized Prospective Study. ( 26133933 )
2015
34
Initial experience with the inspire MD C-Guard stent in the treatment of carotid artery disease. ( 26344378 )
2015
35
Intravascular Near-Infrared Spectroscopy: A Possible Tool for Optimizing the Management of Carotid Artery Disease. ( 26417188 )
2015
36
Renal function and carotid artery disease: many questions, few answers. ( 25045093 )
2014
37
Prevalence and Severity of Asymptomatic Coronary and Carotid Artery Disease in Patients With Abdominal Aortic Aneurysm. ( 24965380 )
2014
38
Spatial mapping of dynamic cerebral autoregulation by multichannel near-infrared spectroscopy in high-grade carotid artery disease. ( 25253194 )
2014
39
A novel mouse model of ischemic carotid artery disease. ( 24940742 )
2014
40
Co-existence of carotid artery disease, renal artery stenosis, and lower extremity peripheral arterial disease in patients with coronary artery disease. ( 24157190 )
2014
41
Carotid artery disease. ( 25362109 )
2014
42
Cognitive impairment and whole brain diffusion in patients with carotid artery disease and ipsilateral transient ischemic attack. ( 24070450 )
2014
43
Managing recurrent carotid artery disease with redo carotid endarterectomy: a 10-year retrospective case series. ( 24529820 )
2014
44
Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels. ( 24904181 )
2014
45
Predicting Carotid Artery Disease and Plaque Instability from Cell-derived Microparticles. ( 25218652 )
2014
46
Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. ( 24651679 )
2014
47
Mean platelet volume predicts outcome in patients with asymptomatic carotid artery disease. ( 24117332 )
2014
48
Role of rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism in carotid artery disease. ( 25238221 )
2014
49
Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease. ( 25217057 )
2014
50
Motor and cognitive impairment in a mouse model of ischemic carotid artery disease. ( 25123442 )
2014

Variations for Carotid Artery Disease

Copy number variations for Carotid Artery Disease from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease

Expression for Carotid Artery Disease

Search GEO for disease gene expression data for Carotid Artery Disease.

Pathways for Carotid Artery Disease

Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 APOA1 APOB APOE LPA
2
Show member pathways
12.06 APOB MMP1 SELE THBD
3
Show member pathways
11.99 APOA1 APOB APOE CCL2 CRP
4 11.9 CCL2 MMP9 SELE THBD
5 11.79 CCL2 MMP9 SELE
6 11.79 CCL2 MMP1 MMP9 TIMP1
7 11.75 CCL2 SELE THBD
8
Show member pathways
11.72 APOA1 APOB APOE CD163
9 11.68 CCL2 MMP9 TIMP1
10
Show member pathways
11.62 MMP1 MMP8 MMP9 TIMP1
11
Show member pathways
11.57 APOA1 APOB APOE
12 11.52 CCL2 MMP9 TIMP1
13
Show member pathways
11.51 MMP1 MMP9 SELE
14 11.49 MMP1 MMP9 TIMP1
15 11.35 APOB LPA MMP9
16 11.24 MMP1 MMP9 SELE
17 10.94 CCL2 MMP9 TIMP1
18 10.82 MMP1 MMP9
19 10.8 ACE APOE CCL2 MMP9
20 10.61 CCL2 MMP1 TIMP1
21 10.46 CCL2 MMP1 MMP9 THBD

GO Terms for Carotid Artery Disease

Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.83 APOE MMP1 MMP8 MMP9 TIMP1
2 proteinaceous extracellular matrix GO:0005578 9.78 MMP1 MMP8 MMP9 TIMP1
3 endoplasmic reticulum lumen GO:0005788 9.76 APOA1 APOB APOE TIMP1
4 extracellular region GO:0005576 9.73 ACE APOA1 APOB APOE CCL2 CD163
5 very-low-density lipoprotein particle GO:0034361 9.58 APOA1 APOB APOE
6 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB APOE
7 low-density lipoprotein particle GO:0034362 9.5 APOA1 APOB APOE
8 chylomicron GO:0042627 9.43 APOA1 APOB APOE
9 extracellular space GO:0005615 9.4 ACE APOA1 APOB APOE CCL2 CRP
10 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 CCL2 CD163 CRP SELE TNFSF4
2 receptor-mediated endocytosis GO:0006898 9.91 APOA1 APOB APOE CD163
3 response to lipopolysaccharide GO:0032496 9.87 APOB CCL2 SELE THBD
4 steroid metabolic process GO:0008202 9.83 APOA1 APOB APOE
5 cellular protein metabolic process GO:0044267 9.83 APOA1 APOB APOE MMP1 TIMP1
6 lipid transport GO:0006869 9.81 APOA1 APOB APOE LPA
7 leukocyte migration GO:0050900 9.8 APOB MMP1 MMP9 SELE THBD
8 collagen catabolic process GO:0030574 9.77 MMP1 MMP8 MMP9
9 cholesterol homeostasis GO:0042632 9.77 APOA1 APOB APOE
10 cholesterol metabolic process GO:0008203 9.76 APOA1 APOB APOE TNFSF4
11 retinoid metabolic process GO:0001523 9.75 APOA1 APOB APOE
12 triglyceride catabolic process GO:0019433 9.67 APOA1 APOB APOE
13 extracellular matrix disassembly GO:0022617 9.67 MMP1 MMP8 MMP9 TIMP1
14 reverse cholesterol transport GO:0043691 9.66 APOA1 APOE
15 high-density lipoprotein particle remodeling GO:0034375 9.65 APOA1 APOE
16 high-density lipoprotein particle assembly GO:0034380 9.65 APOA1 APOE
17 cholesterol efflux GO:0033344 9.65 APOA1 APOB APOE
18 negative regulation of blood coagulation GO:0030195 9.64 APOE THBD
19 phospholipid efflux GO:0033700 9.64 APOA1 APOE
20 leukocyte migration involved in inflammatory response GO:0002523 9.63 CCL2 SELE
21 positive regulation of cholesterol esterification GO:0010873 9.63 APOA1 APOE
22 negative regulation of platelet activation GO:0010544 9.62 APOE THBD
23 high-density lipoprotein particle clearance GO:0034384 9.62 APOA1 APOE
24 chylomicron remnant clearance GO:0034382 9.61 APOB APOE
25 neuron projection regeneration GO:0031102 9.58 APOA1 APOE
26 very-low-density lipoprotein particle clearance GO:0034447 9.56 APOB APOE
27 lipoprotein metabolic process GO:0042157 9.56 APOA1 APOB APOE LPA
28 regulation of Cdc42 protein signal transduction GO:0032489 9.54 APOA1 APOE
29 lipoprotein catabolic process GO:0042159 9.52 APOB APOE
30 low-density lipoprotein particle remodeling GO:0034374 9.5 APOB APOE LPA
31 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
32 chylomicron assembly GO:0034378 9.13 APOA1 APOB APOE
33 chylomicron remodeling GO:0034371 8.8 APOA1 APOB APOE

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.85 ACE LPA MMP1 MMP8 MMP9
2 serine-type endopeptidase activity GO:0004252 9.78 LPA MMP1 MMP8 MMP9
3 metalloendopeptidase activity GO:0004222 9.69 MMP1 MMP8 MMP9
4 phospholipid binding GO:0005543 9.67 APOA1 APOB APOE
5 metallopeptidase activity GO:0008237 9.62 ACE MMP1 MMP8 MMP9
6 endopeptidase activity GO:0004175 9.61 ACE MMP1 MMP9
7 heparin binding GO:0008201 9.56 APOB APOE CCL2 LPA
8 lipoprotein particle binding GO:0071813 9.4 APOA1 APOE
9 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOA1 APOE
10 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOE
11 cholesterol transporter activity GO:0017127 9.13 APOA1 APOB APOE
12 low-density lipoprotein particle receptor binding GO:0050750 8.8 APOB APOE CRP

Sources for Carotid Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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