MCID: CRT016
MIFTS: 46

Carotid Artery Disease malady

Neuronal diseases, Cardiovascular diseases categories

Summaries for Carotid Artery Disease

About this section
Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Your carotid arteries are two large blood vessels in your neck. they supply your brain with blood. if you have carotid artery disease, the arteries become narrow, usually because of atherosclerosis. this is the buildup of cholesterol and other material in an artery. if a blood clot sticks in the narrowed arteries, blood can't reach your brain. this is one of the causes of stroke. carotid artery disease often does not cause symptoms, but there are tests that can tell your doctor if you have it. if the arteries are very narrow, you may need an operation called an endarterectomy to remove the plaque. for less severe narrowing, a medicine to prevent blood clots can reduce your risk of stroke. another option for people who can't have surgery is carotid angioplasty. this involves placing balloons and/or stents into the artery to open it and hold it open.

MalaCards: Carotid Artery Disease, also known as carotid artery diseases, is related to coronary artery disease and myocardial infarction. An important gene associated with Carotid Artery Disease is TNFSF4 (tumor necrosis factor (ligand) superfamily, member 4), and among its related pathways are Degradation of the extracellular matrix and Cell adhesion ECM remodeling. The compounds triacylglycerol and phospholipid have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related mouse phenotype homeostasis/metabolism.

Wikipedia:66 In human anatomy, the left and right common carotid arteries (English pronunciation: /k??r?t?d/) are... more...

Aliases & Classifications for Carotid Artery Disease

About this section
Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Cardiovascular diseases


Aliases & Descriptions:

carotid artery disease 9 11 35
carotid artery diseases 46 63
disorder of carotid artery 9


External Ids:

Disease Ontology9 DOID:3407
NCIt41 C84476
SNOMED-CT59 371160000
MeSH36 D002340
ICD1026 G45.1

Related Diseases for Carotid Artery Disease

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to carotid artery disease

Symptoms for Carotid Artery Disease

About this section

Drugs & Therapeutics for Carotid Artery Disease

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Carotid Artery Disease

Drug clinical trials:

Search ClinicalTrials for Carotid Artery Disease

Search NIH Clinical Center for Carotid Artery Disease

Search CenterWatch for Carotid Artery Disease

Genetic Tests for Carotid Artery Disease

About this section

Anatomical Context for Carotid Artery Disease

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Carotid Artery Disease:

34
Testes, Brain, Heart, Endothelial, Smooth muscle, T cells, Whole blood, Monocytes, Parietal lobe

Animal Models for Carotid Artery Disease or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Carotid Artery Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2MMP7, APOA2, TNFSF4, VLDLR

Publications for Carotid Artery Disease

About this section
Sources:
53PubMed
See all sources

Articles related to Carotid Artery Disease:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Prevalence and severity of asymptomatic coronary and carotid artery disease in patients with lower limbs arterial disease. (23597978)
2013
2
Carotid artery disease and stroke: assessing risk with vessel wall MRI. (23209940)
2012
3
Contrast enhanced ultrasound in atherosclerotic carotid artery disease. (23222935)
2012
4
Impact of plaque haemorrhage and its age on structural stresses in atherosclerotic plaques of patients with carotid artery disease: an MR imaging-based finite element simulation study. (20700655)
2011
5
Trans-Atlantic debate: is carotid artery disease responsible for perioperative strokes after coronary artery bypass surgery? (21166076)
2010
6
Carotid artery disease: stenting vs endarterectomy. (21148654)
2010
7
Three-dimensional volumetric analysis of atherosclerotic plaques: a magnetic resonance imaging-based study of patients with moderate stenosis carotid artery disease. (20532633)
2010
8
Carotid artery disease in patients undergoing elective coronary artery bypass surgery. (20042152)
2009
9
The importance of initiating "best medical therapy" and intervening as soon as possible in patients with symptomatic carotid artery disease: time for a radical rethink of practice. (19935609)
2009
10
Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (18998106)
2009
11
Carotid artery disease development after traumatic injury inflicted by a Ram's Horn. (18782709)
2008
12
Screening for significant carotid artery disease among a cohort of 1,000 Egyptian patients. (18258161)
2008
13
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease. (18073465)
2008
14
Management of carotid artery disease in the high-risk patient with emphasis on the SAPPHIRE study. (17362680)
2007
15
Endothelial apoptosis does not determine symptom status in carotid artery disease. (16968983)
2007
16
Apolipoprotein E polymorphism and preclinical carotid artery disease in untreated hypertensive men. (16449871)
2006
17
Current management of extracranial carotid artery disease. (18473981)
2006
18
Cognitive functions in carotid artery disease before endarterectomy. (16618625)
2006
19
Commentary. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. (16110388)
2005
20
Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Results from the helsinki carotid endarterectomy study. (15775709)
2005
21
Transthoracic echocardiography and carotid Doppler ultrasound for detection of cardiac and carotid artery disease in patients with acute retinal artery obstruction. (15635828)
2004
22
Acute coronary syndromes, plaque vulnerability, and carotid artery disease: the changing role of atherosclerosis imaging. (13678926)
2003
23
Ophthalmologic findings as predictors of carotid artery disease. (12476231)
2002
24
Carotid artery disease: natural history, diagnosis, and therapy. (10348964)
1999
25
Assessment of cerebrovascular reactivity in patients with carotid artery disease using near-infrared spectroscopy. (9779202)
1998
26
Brain SPECT with dipyridamole stress to evaluate cerebral blood flow reserve in carotid artery disease. (8862290)
1996
27
Cerebral haemodynamic considerations in obstructive carotid artery disease. (8686528)
1996
28
Application of transcranial Doppler sonography to evaluate cerebral hemodynamics in carotid artery disease. Comparative analysis of different hemodynamic variables. (7491653)
1995
29
Protruding atheromas of the aortic arch in symptomatic patients with carotid artery disease. (7817922)
1995
30
Risk factors for extracranial internal carotid artery disease. (8073474)
1994
31
Early results of combined carotid endarterectomy and coronary artery bypass grafting in patients with severe coronary and carotid artery disease. (7509401)
1993
32
Detection of intracranial emboli in patients with symptomatic extracranial carotid artery disease. (1440714)
1992
33
Asymmetric proliferative diabetic retinopathy and carotid artery disease. (2381700)
1990
34
Transient visual symptoms and carotid artery disease. Exploration by real-time B-mode echotomography. (2154354)
1990
35
Haemodynamic evaluation of carotid artery disease. (2653704)
1989
36
The impact of intravenous digital subtraction angiography on the evaluation of carotid artery disease: review of the first 600 cases. (3044318)
1988
37
Carotid artery disease: the influence of diabetes mellitus. (3062009)
1988
38
Quantitative ultrasound pulsation study in human carotid artery disease. (3058103)
1988
39
Assessment by fluorescein angiography of surgical treatment of occlusive carotid artery disease. (3590250)
1987
40
Hemorheologic parameters in correlation to extracranial carotid artery disease in patients with acute cerebrovascular disorders. (3305034)
1987
41
Computed tomographic evaluation of extracranial carotid artery disease. (3658128)
1987
42
Noninvasive testing for asymptomatic carotid artery disease. (3463010)
1986
43
Comparison of arteriography and noninvasive techniques for the diagnosis of carotid artery disease. A statistical analysis of 140 patients. (3532890)
1986
44
Cerebrovascular reactivity to acetazolamide in carotid artery disease. Enhancement of side-to-side CBF asymmetry indicates critically reduced perfusion pressure. (2880314)
1986
45
Duplex scanning and periorbital pulsed Doppler in the diagnosis of external carotid artery disease: analysis of causes of error. (3891206)
1985
46
Recognition of carotid artery disease. (3901861)
1985
47
Cerebral haemodynamics in occlusive carotid-artery disease. (2858781)
1985
48
Postganglionic Horner's syndrome in carotid artery disease. (6975435)
1981
49
Horner's syndrome and headache due to carotid artery disease. (1260349)
1976
50
Carotid artery disease and papilledema. (14441742)
1960

Variations for Carotid Artery Disease

About this section

Expression for genes affiliated with Carotid Artery Disease

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carotid Artery Disease

Search GEO for disease gene expression data for Carotid Artery Disease.

Pathways for genes affiliated with Carotid Artery Disease

About this section
Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 13EMD Millipore, 39NCBI BioSystems Database, 54QIAGEN
See all sources

Pathways related to Carotid Artery Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0MMP8, MMP7
2
Show member pathways
9.0MMP8, MMP7
3
Show member pathways
9.0MMP8, MMP7

Compounds for genes affiliated with Carotid Artery Disease

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 25HMDB
See all sources

Compounds related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1triacylglycerol469.5APOA2, VLDLR
2phospholipid469.4APOA2, VLDLR
3(4-aminophenyl)mercuric acetate469.3MMP8, MMP7
4hocl469.3MMP8, MMP7
5uk 383367629.3MMP7, MMP8
6gi 254023x629.3MMP7, MMP8
7gm 6001629.3MMP7, MMP8
8marimastat46 62 1211.2MMP8, MMP7
9batimastat46 62 1211.2MMP8, MMP7
10p002469.1MMP8, MMP7
11fibrinogen468.7APOA2, MMP7, MMP8
12retinoic acid46 259.5APOA2, MMP7, MMP8
13lipid468.5MMP8, APOA2, VLDLR
14glucose468.4MMP8, MMP7, APOA2
15serine468.2VLDLR, APOA2, MMP7, MMP8

GO Terms for genes affiliated with Carotid Artery Disease

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Carotid Artery Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:0343619.4APOA2, VLDLR
2proteinaceous extracellular matrixGO:0055788.7MMP7, MMP8
3extracellular regionGO:0055768.5MMP8, MMP7, APOA2
4extracellular spaceGO:0056158.5MMP8, MMP7, TNFSF4

Biological processes related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute inflammatory responseGO:0025269.6APOA2, TNFSF4
2cholesterol metabolic processGO:0082039.1APOA2, TNFSF4, VLDLR
3collagen catabolic processGO:0305749.1MMP8, MMP7
4extracellular matrix disassemblyGO:0226179.0MMP7, MMP8
5extracellular matrix organizationGO:0301989.0MMP8, MMP7
6proteolysisGO:0065088.9MMP8, MMP7
7response to drugGO:0424938.8MMP7, APOA2

Molecular functions related to Carotid Artery Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.0MMP8, MMP7

Products for genes affiliated with Carotid Artery Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carotid Artery Disease

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet