MCID: CRT016
MIFTS: 58

Carotid Artery Disease

Categories: Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Carotid Artery Disease

MalaCards integrated aliases for Carotid Artery Disease:

Name: Carotid Artery Disease 12 40 14 59
Carotid Artery Diseases 51 41 69
Abnormality of the Carotid Arteries 28
Disorder of Carotid Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3407
MeSH 41 D002340
NCIt 46 C84476
SNOMED-CT 64 371160000
ICD10 32 G45.1
UMLS 69 C0007273

Summaries for Carotid Artery Disease

MedlinePlus : 40 Your carotid arteries are two large blood vessels in your neck. They supply your brain and head with blood. If you have carotid artery disease, the arteries become narrow or blocked, usually because of atherosclerosis. Atherosclerosis is the buildup of plaque, which is made up of fat, cholesterol, calcium, and other substances found in the blood. Carotid artery disease is serious because it can block the blood flow to your brain, causing a stroke. Too much plaque in the artery can cause a blockage. You can also have a blockage when a piece of plaque or a blood clot breaks off the wall of an artery. The plaque or clot can travel through the bloodstream and get stuck in one of your brain's smaller arteries. Carotid artery disease often does not cause symptoms until the blockage or narrowing is severe. One sign may be a bruit (whooshing sound) that your doctor hears when listening to your artery with a stethoscope. Another sign is a transient ischemic attack (TIA), a "mini-stroke." A TIA is like a stroke, but it only lasts a few minutes, and the symptoms usually go away within an hour. Stroke is another sign. Imaging tests can confirm whether you have carotid artery disease. Treatments may include Healthy lifestyle changes Medicines Carotid endarterectomy, surgery to remove the plaque Angioplasty, a procedure to place a balloon and stent into the artery to open it and hold it open NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Carotid Artery Disease, also known as carotid artery diseases, is related to amaurosis fugax and peripheral artery disease, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Carotid Artery Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Cilostazol and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

PubMed Health : 59
About carotid artery disease: Carotid (ka-ROT-id) artery disease is a disease in which a waxy substance called plaque (plak) builds up inside the carotid arteries. You have two common carotid arteries, one on each side of your neck. They each divide into internal and external carotid arteries.The internal carotid arteries supply oxygen-rich blood to your brain. The external carotid arteries supply oxygen-rich blood to your face, scalp, and neck.

Related Diseases for Carotid Artery Disease

Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 30.3 MMP8 MMP9
2 peripheral artery disease 29.9 ACE APOB CCL2 CRP
3 sleep apnea 29.8 ACE APOE CRP
4 carotid stenosis 29.6 ACE APOE CRP MMP1 MMP9
5 acute myocardial infarction 29.5 ACE CRP MMP9 PLG
6 atherosclerosis susceptibility 29.4 ACE APOA1 APOB APOE CCL2 COG2
7 coronary artery anomaly 28.9 ACE APOA1 APOB APOE COG2 CRP
8 arteries, anomalies of 28.9 ACE APOA1 APOB APOE CCL2 COG2
9 cerebrovascular disease 28.8 ACE APOA1 APOB APOE CRP MMP9
10 peripheral vascular disease 28.5 ACE APOA1 APOB CRP LPA SELE
11 hypertension, essential 28.3 ACE APOA1 APOB CRP LPA SELE
12 aortic aneurysm, familial abdominal, 1 28.0 ACE APOE CCL2 CRP MMP1 MMP8
13 stroke, ischemic 28.0 ACE APOB APOE COG2 CRP LPA
14 vascular disease 27.6 ACE APOA1 APOB APOE CCL2 CRP
15 myocardial infarction 26.4 ACE APOA1 APOB APOE CCL2 COG2
16 xanthoma disseminatum 10.6 APOB APOE
17 hypercholesterolemia, autosomal dominant, type b 10.5 APOB APOE
18 defective apolipoprotein b-100 10.5 APOB APOE
19 diabetic foot ulcers 10.4 CRP MMP9
20 familial lcat deficiency 10.4 APOA1 APOE
21 moderate and severe traumatic brain injury 10.4 ACE APOE
22 lipoprotein glomerulopathy 10.4 APOB APOE LPA
23 spastic entropion 10.4 MMP1 MMP9
24 xanthomatosis 10.4 APOB APOE LPA
25 cerebritis 10.4
26 chronic meningitis 10.4 CRP MMP9
27 chronic actinic dermatitis 10.4 MMP1 MMP9
28 acute anterolateral myocardial infarction 10.4 ACE PLG
29 hepatic lipase deficiency 10.4 APOA1 APOE
30 hypobetalipoproteinemia, familial, 1 10.4 APOA1 APOB APOE
31 hyperlipoproteinemia, type iv 10.4 APOA1 APOB APOE
32 hypertriglyceridemia, familial 10.4 APOA1 APOB APOE
33 acute transverse myelitis 10.4 APOA1 MMP9
34 blue toe syndrome 10.4 CRP PLG
35 amyloidosis aa 10.4 APOA1 CRP LPA
36 dysbaric osteonecrosis 10.4 APOA1 APOB PLG
37 hyperlipidemia, familial combined 10.4 APOA1 APOB APOE
38 hyperalphalipoproteinemia 1 10.4 APOA1 APOB APOE
39 abetalipoproteinemia 10.3 APOA1 APOB APOE
40 gallbladder disease 10.3 APOA1 APOB APOE
41 internal hemorrhoid 10.3 MMP1 MMP9
42 generalized atherosclerosis 10.3 ACE APOE CRP
43 chronic venous leg ulcers 10.3 MMP9 TIMP1
44 pelvic inflammatory disease 10.3 CCL2 CRP MMP9
45 aortic valve disease 1 10.3 ACE APOB CRP
46 aortic atherosclerosis 10.3 ACE APOE LPA
47 intermediate coronary syndrome 10.3 ACE CRP PLG
48 head injury 10.3 APOE THBD
49 cerebral atherosclerosis 10.2 ACE APOA1 APOE
50 meningitis 10.2 CCL2 CRP MMP9

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to Carotid Artery Disease

Symptoms & Phenotypes for Carotid Artery Disease

UMLS symptoms related to Carotid Artery Disease:


edema, chest pain, angina pectoris

GenomeRNAi Phenotypes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Carotid Artery Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 APOB PLG APOE SELE CD163 SLC39A2
2 cardiovascular system MP:0005385 10.11 TIMP1 APOB PLG APOE SELE CD163
3 immune system MP:0005387 10.07 TIMP1 APOB PLG APOE SELE CCL2
4 liver/biliary system MP:0005370 9.76 APOA1 APOB PLG APOE SELE SLC39A2
5 neoplasm MP:0002006 9.43 TIMP1 MMP9 PLG MMP1 MMP8 ACE
6 respiratory system MP:0005388 9.17 TIMP1 MMP9 PLG APOE SELE CD163

Drugs & Therapeutics for Carotid Artery Disease

PubMedHealth treatment related to Carotid Artery Disease: 59

Treatments for carotid artery disease may include lifestyle changes, medicines, and medical procedures. The goals of treatment are to stop the disease from getting worse and to prevent a stroke.Your treatment will depend on your symptoms, how severe the disease is, and your age and overall health.

Drugs for Carotid Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 227)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
3
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
4
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
5
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
6
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
7
Metformin Approved Phase 4 657-24-9 4091 14219
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
13
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
14
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
15
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
16
Glyburide Approved Phase 4 10238-21-8 3488
17
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
18
Losartan Approved Phase 4 114798-26-4 3961
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
20
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 59-67-6 938
21
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 98-92-0 936
22
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
23 tannic acid Approved, Nutraceutical Phase 4,Phase 3
24 Anti-Asthmatic Agents Phase 4
25 Autonomic Agents Phase 4
26 Bronchodilator Agents Phase 4
27 Fibrinolytic Agents Phase 4,Phase 2,Phase 3
28 Neuroprotective Agents Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
30 Phosphodiesterase 3 Inhibitors Phase 4
31 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
32 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
33 Protective Agents Phase 4,Phase 2,Phase 3
34 Respiratory System Agents Phase 4
35 Vasodilator Agents Phase 4,Phase 3,Phase 2
36 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
37 Antimetabolites Phase 4,Phase 3,Phase 2
38 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
39 Calcium, Dietary Phase 4,Phase 3,Phase 2
40 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
42 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
43 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
44 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
45 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2
46 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2
47 Micronutrients Phase 4,Phase 2
48 Trace Elements Phase 4,Phase 2
49 Vitamins Phase 4,Phase 2
50 Hypoglycemic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 319)

# Name Status NCT ID Phase Drugs
1 SAPPHIRE Worldwide: Stenting and Angioplasty With Protection in Patients At High-Risk for Endarterectomy Unknown status NCT00403078 Phase 4
2 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
3 Carotid Artery Stenting With Cilostazol Addition for Restenosis Unknown status NCT01261234 Phase 4 Cilostazol or Non-Cilostazol
4 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
5 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
6 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
7 Carotid Revascularization With ev3 Arterial Technology Evolution Post Approval Study Completed NCT00530504 Phase 4
8 A Carotid Stenting Boston Scientific Surveillance Program Completed NCT00741091 Phase 4
9 CHOICE: Carotid Stenting For High Surgical-Risk Patients Completed NCT00406055 Phase 4
10 CAPTURE 2 Post-Marketing Registry Completed NCT00302237 Phase 4
11 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
12 Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
13 The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT) Completed NCT01341730 Phase 4 Atorvastatin 20mg;Atorvastatin 20 mg + Pioglitazone 30 mg
14 Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT) Completed NCT01203982 Phase 4 Rosuvastatin;Rosuvastatin
15 Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study Completed NCT00723307 Phase 4 Metformin;Placebo
16 Stop Atherosclerosis in Native Diabetics Study Completed NCT00147251 Phase 4 FDA approved drugs to treat blood pressure and cholesterol
17 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
18 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
19 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
20 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
21 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
22 A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques Recruiting NCT02532309 Phase 4 Rosuvastatin (5mg,10mg,20mg);Rosuvastatin 5mg
23 Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus Recruiting NCT02162550 Phase 4 Bydureon;placebo
24 Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes Recruiting NCT03248401 Phase 4 Cilostazol;Aspirin
25 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
26 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication Active, not recruiting NCT00715273 Phase 4 Atorvastatin;Niacin;Colesevelam;Placebo Niacin;Placebo Colesevelam
27 Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery Not yet recruiting NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
28 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Not yet recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
29 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
30 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
31 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
32 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
33 Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI) Withdrawn NCT00388843 Phase 4
34 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
35 Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure Completed NCT01685567 Phase 3
36 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
37 Carotid With Bivalirudin Angioplasty Completed NCT00812383 Phase 2, Phase 3
38 Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) Completed NCT00231270 Phase 3
39 Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) Completed NCT00231231 Phase 3
40 Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty Completed NCT01264419 Phase 3
41 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
42 Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis Completed NCT02133807 Phase 3
43 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
44 Atherosclerosis Monitoring and Atherogenicity Reduction Study Completed NCT01734707 Phase 3 Placebo
45 Effects of Lutein Supplementation on Subclinical Atherosclerosis Completed NCT01534533 Phase 2, Phase 3
46 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
47 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
48 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
49 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
50 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)

Search NIH Clinical Center for Carotid Artery Disease

Cochrane evidence based reviews: carotid artery diseases

Genetic Tests for Carotid Artery Disease

Genetic tests related to Carotid Artery Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Carotid Arteries 28

Anatomical Context for Carotid Artery Disease

MalaCards organs/tissues related to Carotid Artery Disease:

38
Brain, Heart, Testes, Lung, Endothelial, Kidney, Ovary

Publications for Carotid Artery Disease

Articles related to Carotid Artery Disease:

(show top 50) (show all 593)
# Title Authors Year
1
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
2
The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review. ( 29334161 )
2018
3
Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial. ( 29389037 )
2018
4
Transcarotid Transcatheter Aortic Valve Replacement as Preferred Alternative Access in a Patient With Bilateral Carotid Artery Disease. ( 29289952 )
2018
5
Approach to concurrent coronary and carotid artery disease: Epidemiology, screening and treatment. ( 29451667 )
2017
6
Concomitant Surgical Treatment of Symptomatic Carotid Artery Disease With a Coexisting Shamblin I Carotid Body Tumor. ( 28118794 )
2017
7
Contemporary medical therapies of atherosclerotic carotid artery disease. ( 28818261 )
2017
8
Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease. ( 29189170 )
2017
9
Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease. ( 28776469 )
2017
10
Contemporary Management of Patients with Concomitant Coronary and Carotid Artery Disease. ( 28785837 )
2017
11
Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy. ( 28196937 )
2017
12
Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke. ( 29311973 )
2017
13
Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. ( 29132880 )
2017
14
Carotid artery disease and neurocognitive impairment. ( 28560984 )
2017
15
OCULAR ARTERIAL OCCLUSIVE DISORDERS AND CAROTID ARTERY DISEASE. ( 28547004 )
2017
16
Regional variation in patient selection and treatment for carotid artery disease in the Vascular Quality Initiative. ( 28359719 )
2017
17
Hybrid Treatment of Extracranial Carotid Artery Disease. ( 28604285 )
2017
18
The association of the circle of Willis anomaly and risk of stroke in patients with carotid artery disease. ( 28746428 )
2017
19
Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease. ( 29326849 )
2017
20
Symptomatic Carotid Artery Disease: Revascularization. ( 28442330 )
2017
21
Carotid Duplex Ultrasonography: Additional Imaging Is Rarely Necessary for Appropriate Treatment Planning for Carotid Artery Disease. ( 28424133 )
2017
22
Biobanking in carotid artery disease: translation to clinical practice. ( 28051291 )
2017
23
Endovascular prevention and treatment of stroke related to extracranial carotid artery disease. ( 27922251 )
2017
24
Selective-versus-Standard Poststent Dilation for Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 28302610 )
2017
25
Carotid artery disease and neurocognitive impairment. ( 28560985 )
2017
26
Carotid artery disease and perioperative stroke risk after surgical aortic valve replacement: A nationwide inpatient sample analysis. ( 28454636 )
2017
27
Carotid artery disease and periprocedural stroke risk after transcatheter aortic valve implantation. ( 28393772 )
2017
28
Effects of Obstructive Carotid Artery Disease on Ocular Circulation and the Safety of Carotid Artery Stenting. ( 28162948 )
2017
29
Carotid Artery Disease as a Predictor of In-Hospital Postoperative Stroke After Coronary Artery Bypass Grafting From 1999 to 2011. ( 29169797 )
2017
30
Chronic arsenic exposure and risk of carotid artery disease: The Strong Heart Study. ( 28554006 )
2017
31
Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease. ( 26799121 )
2016
32
Multi-parametric ultrasound criteria for internal carotid artery disease-comparison with CT angiography. ( 27230916 )
2016
33
Additional value of inflammatory biomarkers and carotid artery disease in prediction of significant coronary artery disease as assessed by coronary computed tomography angiography. ( 27742738 )
2016
34
Neurocognitive Improvement in Patients Undergoing Carotid Endarterectomy for Atherosclerotic Occlusive Carotid Artery Disease. ( 28018503 )
2016
35
Prevalence of Carotid Artery Disease among Ambulatory Patients with Coronary Artery Disease. ( 26979002 )
2016
36
Carotid artery disease progression and related neurologic events after carotid endarterectomy. ( 27021378 )
2016
37
White Matter Diffusion Abnormalities in Carotid Artery Disease: A Systematic Review and Meta-Analysis. ( 27079165 )
2016
38
Lower extremity and carotid artery disease in COPD. ( 28053972 )
2016
39
Surgical Versus Percutaneous Therapy of Carotid Artery Disease: An Evidence-Based Outcomes Analysis. ( 27712968 )
2016
40
Initial experience with the inspire MD C-Guard stent in the treatment of carotid artery disease. ( 27094426 )
2016
41
Lesion Topography and Microscopic White Matter Tract Damage Contribute to Cognitive Impairment in Symptomatic Carotid Artery Disease. ( 27598537 )
2016
42
Cerebrovascular reactivity in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery disease. ( 27743788 )
2016
43
Extracranial Carotid Artery Disease: Risk Factors and Outcomes in Patients With Acute Critical Hemispheric Ischemic Stroke. ( 26764275 )
2016
44
Intravascular Near-Infrared Spectroscopy: A Possible Tool for Optimizing the Management of Carotid Artery Disease. ( 26417188 )
2015
45
Teaching NeuroImages: Radiation-associated symptomatic carotid artery disease with ipsilateral radiodermatitis. ( 25646279 )
2015
46
Stroke prevention in asymptomatic carotid artery disease: revascularization of carotid stenosis is not the solution. ( 25883075 )
2015
47
Atherosclerotic Plaque Composition Is Still an Almost Unrecognized Factor of Risk Stratification in Patients with Carotid Artery Disease. ( 26417182 )
2015
48
The Effects of Near-Infrared Spectroscopy on the Neurocognitive Functions in the Patients Undergoing Coronary Artery Bypass Grafting with Asymptomatic Carotid Artery Disease: A Randomized Prospective Study. ( 26133933 )
2015
49
No Evidence for Retinal Damage Evolving from Reduced Retinal Blood Flow in Carotid Artery Disease. ( 26558275 )
2015
50
Asymptomatic carotid artery disease: A personalized approach to management. ( 26651895 )
2015

Variations for Carotid Artery Disease

Copy number variations for Carotid Artery Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 49065 11 102660640 102668966 Copy number MMP1 Carotid artery disease
2 49067 11 102706527 102714342 Copy number MMP3 Carotid artery disease
3 163976 22 33196801 33259027 Copy number TIMP3 Carotid artery disease
4 207773 6 160952515 161087407 Copy number LPA Carotid artery disease
5 207774 6 160952515 161087407 Copy number LPAL2 Carotid artery disease
6 207775 6 160952515 161087407 Copy number PLG Carotid artery disease

Expression for Carotid Artery Disease

Search GEO for disease gene expression data for Carotid Artery Disease.

Pathways for Carotid Artery Disease

Pathways related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 APOA1 APOB MMP1 PLG SELE THBD
2
Show member pathways
12.64 MMP1 MMP8 MMP9 PLG TIMP1
3
Show member pathways
12.45 APOA1 APOB APOE LPA
4
Show member pathways
12.1 APOB MMP1 SELE THBD
5 11.98 CCL2 MMP9 SELE THBD
6
Show member pathways
11.9 APOA1 APOB APOE LPA
7 11.87 CCL2 MMP1 MMP9 TIMP1
8 11.81 CCL2 MMP9 SELE
9
Show member pathways
11.81 APOA1 APOB APOE CD163
10 11.77 CCL2 SELE THBD
11 11.71 CCL2 MMP9 TIMP1
12 11.55 CCL2 MMP9 TIMP1
13
Show member pathways
11.54 MMP1 MMP9 SELE
14 11.49 MMP1 MMP9 PLG TIMP1
15
Show member pathways
11.43 APOA1 APOB APOE CCL2 CRP PLG
16 11.35 APOB LPA MMP9 PLG
17
Show member pathways
11.35 MMP1 MMP8 MMP9 PLG TIMP1
18 11.21 MMP1 MMP9 PLG SELE
19 11.09 CCL2 MMP1 MMP9 THBD
20 11.05 CCL2 MMP9 TIMP1
21 10.99 ACE MMP9 PLG
22 10.96 ACE APOE CCL2 MMP9
23 10.89 CCL2 MMP1 TIMP1
24 10.84 MMP1 MMP9

GO Terms for Carotid Artery Disease

Cellular components related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.8 MMP1 MMP8 MMP9 TIMP1
2 endoplasmic reticulum lumen GO:0005788 9.78 APOA1 APOB APOE TIMP1
3 extracellular region GO:0005576 9.77 ACE APOA1 APOB APOE CCL2 CD163
4 extracellular matrix GO:0031012 9.73 APOA1 APOE MMP1 MMP8 MMP9 TIMP1
5 very-low-density lipoprotein particle GO:0034361 9.61 APOA1 APOB APOE
6 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
7 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
8 chylomicron GO:0042627 9.5 APOA1 APOB APOE
9 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
10 extracellular space GO:0005615 9.4 ACE APOA1 APOB APOE CCL2 CRP
11 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE

Biological processes related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.87 APOA1 APOB APOE CD163
2 platelet degranulation GO:0002576 9.83 APOA1 PLG TIMP1
3 steroid metabolic process GO:0008202 9.83 APOA1 APOB APOE
4 cholesterol metabolic process GO:0008203 9.8 APOA1 APOB APOE
5 lipid transport GO:0006869 9.8 APOA1 APOB APOE LPA
6 leukocyte migration GO:0050900 9.8 APOB MMP1 MMP9 SELE THBD
7 cholesterol homeostasis GO:0042632 9.77 APOA1 APOB APOE
8 collagen catabolic process GO:0030574 9.75 MMP1 MMP8 MMP9
9 retinoid metabolic process GO:0001523 9.73 APOA1 APOB APOE
10 reverse cholesterol transport GO:0043691 9.65 APOA1 APOE
11 high-density lipoprotein particle remodeling GO:0034375 9.65 APOA1 APOE
12 triglyceride catabolic process GO:0019433 9.65 APOA1 APOB APOE
13 negative regulation of blood coagulation GO:0030195 9.64 APOE THBD
14 high-density lipoprotein particle assembly GO:0034380 9.64 APOA1 APOE
15 phospholipid efflux GO:0033700 9.63 APOA1 APOE
16 lipoprotein metabolic process GO:0042157 9.63 APOA1 APOB APOE
17 negative regulation of fibrinolysis GO:0051918 9.62 PLG THBD
18 negative regulation of platelet activation GO:0010544 9.62 APOE THBD
19 positive regulation of cholesterol esterification GO:0010873 9.61 APOA1 APOE
20 high-density lipoprotein particle clearance GO:0034384 9.61 APOA1 APOE
21 cholesterol efflux GO:0033344 9.61 APOA1 APOB APOE
22 chylomicron remnant clearance GO:0034382 9.59 APOB APOE
23 neuron projection regeneration GO:0031102 9.58 APOA1 APOE
24 regulation of Cdc42 protein signal transduction GO:0032489 9.55 APOA1 APOE
25 very-low-density lipoprotein particle clearance GO:0034447 9.54 APOB APOE
26 low-density lipoprotein particle remodeling GO:0034374 9.54 APOB APOE LPA
27 lipoprotein catabolic process GO:0042159 9.51 APOB APOE
28 chylomicron assembly GO:0034378 9.5 APOA1 APOB APOE
29 chylomicron remodeling GO:0034371 9.43 APOA1 APOB APOE
30 cellular protein metabolic process GO:0044267 9.43 APOA1 APOB APOE MMP1 PLG TIMP1
31 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
32 extracellular matrix disassembly GO:0022617 9.02 MMP1 MMP8 MMP9 PLG TIMP1
33 proteolysis GO:0006508 10 ACE LPA MMP1 MMP8 MMP9 PLG

Molecular functions related to Carotid Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.85 ACE LPA MMP1 MMP8 MMP9 PLG
2 metallopeptidase activity GO:0008237 9.71 ACE MMP1 MMP8 MMP9
3 metalloendopeptidase activity GO:0004222 9.69 MMP1 MMP8 MMP9
4 phospholipid binding GO:0005543 9.65 APOA1 APOB APOE
5 serine-type endopeptidase activity GO:0004252 9.65 LPA MMP1 MMP8 MMP9 PLG
6 lipid transporter activity GO:0005319 9.5 APOA1 APOB APOE
7 apolipoprotein binding GO:0034185 9.49 LPA PLG
8 lipoprotein particle binding GO:0071813 9.46 APOA1 APOE
9 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.43 APOA1 APOE
10 low-density lipoprotein particle receptor binding GO:0050750 9.33 APOB APOE CRP
11 endopeptidase activity GO:0004175 9.26 ACE MMP1 MMP9 PLG
12 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE

Sources for Carotid Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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