MCID: CRT016
MIFTS: 49

Carotid Artery Disease malady

Neuronal category

Summaries for Carotid Artery Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your carotid arteries are two large blood vessels in your neck. they supply your brain with blood. if you have carotid artery disease, the arteries become narrow, usually because of atherosclerosis. this is the buildup of cholesterol and other material in an artery. if a blood clot sticks in the narrowed arteries, blood can't reach your brain. this is one of the causes of stroke. carotid artery disease often does not cause symptoms, but there are tests that can tell your doctor if you have it. if the arteries are very narrow, you may need an operation called an endarterectomy to remove the plaque. for less severe narrowing, a medicine to prevent blood clots can reduce your risk of stroke. another option for people who can't have surgery is carotid angioplasty. this involves placing balloons and/or stents into the artery to open it and hold it open.

MalaCards: Carotid Artery Disease, also known as carotid artery diseases, is related to coronary artery disease, and vascular disease. An important gene associated with Carotid Artery Disease is PON1 (paraoxonase 1), and among its related pathways are LDL-mediated lipid transport and Scavenging by Class B Receptors. The compounds warfarin and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:64 In human anatomy, the left and right common carotid arteries (English pronunciation: /kəˈrɒtɪd/) are... more...

Aliases & Classifications for Carotid Artery Disease

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

carotid artery disease 8 10 34
carotid artery diseases 45 61
disorder of carotid artery 8


External Ids:

Disease Ontology8 DOID:3407
MeSH35 D002340
SNOMED-CT57 371160000
NCIt40 C84476
ICD1025 G45.1

Related Diseases for Carotid Artery Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Carotid Artery Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease,31.2SELE, ACE, THBD, MMP7, CD14, PON1
2vascular disease30.9SELE, ACE, THBD, PON1, LPA, APOB
3carotid stenosis30.8MMP1, PON1
4stroke, ischemic30.7SELE, ACE, LPA, APOB, APOE, APOA1
5atherosclerosis30.4SELE, ACE, THBD, MMP1, MMP8, CD14
6sickle cell disease30.3SELE
7peripheral vascular disease30.3SELE, THBD, CCL2
8acute myocardial infarction30.0SELE, ACE, THBD, MMP8, CD14, PON1
9lip disease10.5
10brain disease10.5
11carotid artery occlusion10.4
12amaurosis fugax10.4
13neovascular glaucoma10.3
14aortic disease10.3
15headache10.3
16central retinal artery occlusion10.2
17sickle cell anemia10.2
18horner's syndrome10.2
19aneurysm disease10.2
20cough headache10.2
21cardiovascular disease risk factor10.2
22proliferative diabetic retinopathy10.1
23renovascular hypertension10.1
24coronary aneurysm10.1
25intermittent claudication10.1
26intracranial aneurysm10.1
27carotid artery dissection10.1
28renal artery atheroma10.1
29coronary artery aneurysm10.1
30autonomic dysfunction10.1
31brain ischemia10.1
32familial hypertriglyceridemia10.0APOB
33lipodystrophy10.0APOB
34astrocytoma10.0APOB
35cerebral palsy10.0MMP8
36lupus erythematosus10.0THBD
37ovarian cancer10.0MMP7
38infertility10.0PON1
39acromegaly10.0LPA
40polyneuropathy10.0APOA2
41hyperthyroidism10.0APOA2
42eclampsia10.0THBD
43acute pancreatitis10.0CD14
44amyotrophic lateral sclerosis10.0PON1
45biliary atresia10.0MMP7
46malaria10.0CCL5
47sarcoma10.0MMP7
48dermatitis10.0SELE
49bronchiolitis10.0CCL5
50cystic fibrosis10.0PON1

Graphical network of the top 20 diseases related to Carotid Artery Disease:



Diseases related to carotid artery disease

Clinical Features for Carotid Artery Disease

Drugs & Therapeutics for Carotid Artery Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Carotid Artery Disease

Drug clinical trials:

Search ClinicalTrials for Carotid Artery Disease

Search NIH Clinical Center for Carotid Artery Disease

Search CenterWatch for Carotid Artery Disease

Genetic Tests for Carotid Artery Disease

Anatomical Context for Carotid Artery Disease

Animal Models for Carotid Artery Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Carotid Artery Disease

Sources:
51PubMed
See all sources

Articles related to Carotid Artery Disease:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Safety and mid-term outcome of endovascular therapy for internal carotid artery disease: a 15-year experience at a single-centre angiology institution. (23644371)
2013
2
Cerebrovascular reacivity assessment in patients with carotid artery disease: a combined TCD and NIRS study. (21447029)
2012
3
Current strategies and possible perspectives of ultrasonic risk stratification of ischemic stroke in internal carotid artery disease. (21154214)
2011
4
Carotid artery disease and stenting: insights from recent clinical trials. (21318556)
2011
5
Intracranial carotid artery stent placement causes delayed severe intracranial hemorrhage in a patient with moyamoya disease. (21990810)
2011
6
Three-dimensional volumetric analysis of atherosclerotic plaques: a magnetic resonance imaging-based study of patients with moderate stenosis carotid artery disease. (20532633)
2010
7
Carotid artery disease and stroke during coronary artery bypass surgery. (21063256)
2010
8
Editors' commentary. Is carotid artery disease responsible for perioperative strokes after coronary artery bypass surgery? (21146754)
2010
9
Coagulation activation and ultrasound characteristics in patients with carotid artery disease. (19796792)
2010
10
Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. (20847302)
2010
11
Commentary on "Carotid artery disease: selecting the appropriate asymptomatic patient for intervention". (20798076)
2010
12
Accuracy of magnetic resonance angiography for internal carotid artery disease. (19038909)
2009
13
Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation. (19533651)
2009
14
Carotid artery disease. Blood flow to the brain matters. (19718782)
2009
15
Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. (18675980)
2009
16
Carotid artery disease development after traumatic injury inflicted by a Ram's Horn. (18782709)
2008
17
Management of atherosclerotic carotid artery disease: clinical practice guidelines of the Society for Vascular Surgery. (18644494)
2008
18
Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. (17576871)
2007
19
Apolipoprotein E polymorphism and preclinical carotid artery disease in untreated hypertensive men. (16449871)
2006
20
Multi-detector row CT angiography in the assessment of carotid artery disease in symptomatic patients: comparison with rotational angiography and digital subtraction angiography. (15891155)
2005
21
Diagnostic performance of duplex ultrasound in patients suspected of carotid artery disease: the ipsilateral versus contralateral artery. (16151031)
2005
22
Infarct patterns in atherosclerotic middle cerebral artery versus internal carotid artery disease. (15111664)
2004
23
Colour-duplex echography in atherosclerotic carotid artery disease. (15053462)
2004
24
Interrelationship between peripheral arterial occlusive disease, carotid atherosclerosis and flow mediated dilation of the brachial artery. (12771862)
2003
25
The impact of asymptomatic carotid artery disease on the intraoperative course of coronary artery bypass surgery. (12705645)
2003
26
The cost-effectiveness of magnetic resonance angiography for carotid artery stenosis and peripheral vascular disease: a systematic review. (12022939)
2002
27
Neck irradiation: a risk factor for occlusive carotid artery disease. (11991689)
2002
28
Microembolic signals and early recurrent cerebral ischemia in carotid artery disease. (10390331)
1999
29
Symptomatic and asymptomatic carotid artery lesions in peripheral vascular disease: a prospective study. (12774462)
1999
30
Assessment of cerebrovascular reactivity in patients with carotid artery disease using near-infrared spectroscopy. (9779202)
1998
31
An audit of carotid endarterectomy for internal carotid artery disease at Dunedin Hospital. (18639065)
1998
32
Carotid artery disease practice guidelines for the general practitioner. (8885557)
1996
33
Microembolism in Carotid Artery Disease. (11442965)
1996
34
Risk factors for extracranial internal carotid artery disease. (8073474)
1994
35
Carotid artery disease. (7919691)
1994
36
Incidence of bilateral intraplaque hemorrhage in carotid artery disease. (8076129)
1993
37
Electroretinography, retinal ischaemia and carotid artery disease. (2279565)
1990
38
Regional cerebral blood flow in patients with leuko-araiosis and atherosclerotic carotid artery disease. (2322132)
1990
39
Extracranial carotid artery disease in patients with arterial limb embolism. (2911826)
1989
40
The haemodynamic value of external carotid artery collateral blood supply in carotid artery disease. (3069499)
1988
41
Carotid artery disease. A therapeutic enigma. (3337704)
1988
42
The effect of carotid artery disease on the cerebrovascular response to physiologic stimulation. (3261847)
1988
43
Prevalence of extracranial carotid artery disease: a survey of an asymptomatic population with noninvasive techniques. (3550161)
1987
44
Comparison of duplex Doppler scanning with contrast angiography in carotid artery disease. (3424031)
1987
45
Fibromuscular dysplasia of the internal carotid artery: an unusual cause of reversible ischemic neurologic disease. (3766038)
1986
46
Comparison of arteriography and noninvasive techniques for the diagnosis of carotid artery disease. A statistical analysis of 140 patients. (3532890)
1986
47
Cerebral haemodynamics in occlusive carotid-artery disease. (2858781)
1985
48
Bilateral visual loss in carotid artery disease. (2947913)
1985
49
Carotid artery disease and central retinal artery occlusion. (436273)
1979
50
A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. VI. X-ray irradiation, carotid artery occlusion, collagen vascular disease, and vitritis. (5684309)
1968

Genetic Variations for Carotid Artery Disease

Expression for genes affiliated with Carotid Artery Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carotid Artery Disease

Search GEO for disease gene expression data for Carotid Artery Disease.

Pathways for genes affiliated with Carotid Artery Disease

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 50PharmGKB, 53R&D Systems
See all sources

Pathways related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1LPA, APOB
210.0APOA1, APOB
3
Cell adhesion ECM remodeling
Hide members
9.9MMP1, MMP7, MMP8
4
Hide members
9.9MMP1, MMP7, MMP8
59.8CCL5, MMP7, MMP1
69.7MMP1, APOA2, APOA1
7
Hide members
9.7APOA1, APOE, APOB
89.7APOB, APOE, APOA1
9
Hide members
9.7THBD, F10, APOA2
10
Cell adhesion Cell-matrix glycoconjugates
Hide members
9.7CCL5, MMP1, SELE
119.7APOB, APOA1, CCL2
129.6CCL2, MMP1, THBD
139.6LPA, APOB, APOA2, APOA1
149.6SELE, THBD, MMP1, APOB
15
Hide members
9.5APOA1, APOE, APOA2, APOB
16
Hide members
9.5APOA1, APOE, APOA2, APOB
17
Hide members
9.3LPA, APOB, APOA2, APOE, APOA1
18
Hide members
9.3F10, MMP8, MMP7, MMP1, THBD
19
Hide members
9.3ACE, CD14, CCL2, CCL5
20
Hide members
9.3CCL5, CCL2, MMP8, MMP7, MMP1
219.2CCL2, APOE, CD14, ACE

Compounds for genes affiliated with Carotid Artery Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.6LPA
2cycloheximide4510.4F10
3estrogen4510.2COG2, LPA
4rosiglitazone45 50 29 11 2414.2MMP1, COG2
5vitamin a45 11 2411.7LPA, MMP1, APOA1, PON1, APOB
6cholestyramine459.6LPA, APOB, APOE, COG2
7sele459.6PON1, APOE, SELE, ACE
87-ketocholesterol45 2410.6APOA1, APOB, PON1, APOE
9tibolone459.5APOA1, APOB, MMP1, CCL2, SELE
10probucol45 1110.4APOB, CCL2, APOA1, SELE, APOE
11hocl459.4LPA, MMP7, MMP8, PON1
12dextran sulfate459.4APOA1, SELE, APOB, MMP7, F10
13retinyl palmitate45 2410.4COG2, APOB, APOE, APOA1
14dimyristoylphosphatidylcholine459.4APOA1, APOE, LPA, APOA2
15vitamin b12459.4CCL2, APOA1, APOE, APOB, LPA, PON1
16h2o2459.3MMP1, THBD, LPA, F10, PON1, MMP8
17bezafibrate45 29 1111.2APOE, APOA2, APOB, LPA, COG2, APOA1
18folate459.2APOB, THBD, PON1, LPA, CCL5, SELE
19triacylglycerol459.2VLDLR, APOB, APOA2, APOE, APOA1, COG2
20polyethylene glycol459.2THBD, PON1, F10, APOE, APOA1, SELE
21glucose459.1THBD, MMP7, MMP8, CD14, LPA, APOA2
22gemfibrozil45 29 1111.1COG2, PON1, LPA, APOB, APOA2, APOE
23cerivastatin45 50 29 1112.1APOB, MMP1, CCL2, CCL5, COG2, APOA1
24cholesterol ester459.1APOB, COG2, APOA2, APOA1, APOE, LPA
25pioglitazone45 50 29 1112.1COG2, MMP1, MMP7, APOB, APOA1, CCL2
26lovastatin45 50 60 29 1113.0PON1, LPA, CD14, APOE, APOA1, COG2
27thyroxine45 2410.0THBD, PON1, LPA, APOB, APOE, COG2
28losartan45 50 29 1112.0APOE, SELE, ACE, THBD, MMP1, CCL2
29polysaccharide458.9APOB, SELE, PON1, F10, CD14, THBD
30serine458.9MMP1, APOA2, F10, VLDLR, MMP8, SELE
31lactate458.7SELE, MMP1, THBD, MMP8, CD14, F10
32heparin45 29 11 2411.6APOA2, LPA, VLDLR, PON1, SELE, CCL5
33fenofibrate45 50 1110.6SELE, PON1, LPA, APOB, APOA2, APOA1
34phospholipid458.5COG2, APOA1, APOE, THBD, PON1, VLDLR
35fluvastatin45 50 29 1111.4MMP1, THBD, SELE, APOB, APOE, APOA1
36phosphatidylcholine458.4THBD, SELE, PON1, F10, LPA, CCL2
37cysteine458.4THBD, CD14, CCL5, MMP8, APOE, MMP1
38atorvastatin45 50 29 11 2412.2CCL2, COG2, APOA1, APOE, APOB, SELE
39pravastatin45 50 29 11 2412.2CCL2, APOA1, APOE, APOB, LPA, PON1
40arginine458.1CD14, PON1, F10, LPA, APOA2, APOE
41homocysteine45 249.0SELE, APOE, APOA1, CCL2, CCL5, COG2
42alanine458.0APOB, SELE, F10, PON1, CD14, APOE
43nitric oxide45 11 2410.0SELE, ACE, MMP8, LPA, CCL2, CCL5
44vegf458.0APOE, LPA, MMP8, CCL2, CCL5, MMP7
45simvastatin45 50 60 29 11 2412.9SELE, THBD, PON1, F10, LPA, APOB
46fibrinogen457.7COG2, CCL2, APOA1, APOA2, APOB, LPA
47aspirin45 50 29 2410.7APOE, LPA, F10, PON1, MMP1, THBD
48cholesterol45 29 11 2410.3APOB, LPA, VLDLR, PON1, CD14, THBD
49creatinine457.2MMP1, PON1, SELE, CD14, THBD, VLDLR
50lipid457.1APOE, APOA2, APOB, LPA, VLDLR, PON1

GO Terms for genes affiliated with Carotid Artery Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1spherical high-density lipoprotein particleGO:03436610.0PON1, APOA2, APOA1
2chylomicronGO:0426279.9APOB, APOA2, APOE
3intermediate-density lipoprotein particleGO:0343639.9APOE, APOB
4endocytic vesicle lumenGO:0716829.8APOA1, APOE, APOB
5high-density lipoprotein particleGO:0343649.7APOA1, APOE, APOA2, PON1
6very-low-density lipoprotein particleGO:0343619.5APOA1, APOE, APOA2, APOB, VLDLR
7early endosomeGO:0057699.5APOB, APOA2, APOE, APOA1
8endoplasmic reticulum lumenGO:0057889.2F10, APOB, APOA2, APOA1
9extracellular spaceGO:0056157.8APOE, APOA1, TNFSF4, CCL2, CCL5, APOB
10plasma membraneGO:0058867.7APOE, APOB, F10, VLDLR, CD14, THBD
11extracellular regionGO:0055767.3ACE, CCL5, CCL2, APOA1, APOE, APOA2

Biological processes related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipase activityGO:06019210.3APOA1, APOA2
2lipoprotein catabolic processGO:04215910.3APOE, APOB
3negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.3APOA1, APOA2
4very-low-density lipoprotein particle clearanceGO:03444710.3APOE, VLDLR
5regulation of intestinal cholesterol absorptionGO:03030010.3APOA1, APOA2
6protein oxidationGO:01815810.3APOA1, APOA2
7negative regulation of cytokine secretion involved in immune responseGO:00274010.3APOA1, APOA2
8peptidyl-methionine modificationGO:01820610.2APOA2, APOA1
9regulation of Cdc42 protein signal transductionGO:03248910.2APOA1, APOE
10low-density lipoprotein particle remodelingGO:03437410.2APOB, APOA2, APOE
11retinoid metabolic processGO:00152310.2APOE, APOA2, APOB
12peripheral nervous system axon regenerationGO:01401210.2APOA1, APOE
13lipoprotein biosynthetic processGO:04215810.1APOA1, APOE, APOB
14positive regulation of macrophage chemotaxisGO:01075910.1CCL2, CCL5
15negative regulation of platelet activationGO:01054410.1THBD, APOE
16high-density lipoprotein particle assemblyGO:03438010.1APOA1, APOE, APOA2
17high-density lipoprotein particle clearanceGO:03438410.1APOA2, APOE, APOA1
18positive regulation of cholesterol esterificationGO:01087310.1APOA1, APOE, APOA2
19phospholipid effluxGO:03370010.1APOA1, APOE, APOA2
20high-density lipoprotein particle remodelingGO:03437510.1APOA2, APOE, APOA1
21positive regulation of cholesterol effluxGO:01087510.1PON1, APOE
22reverse cholesterol transportGO:04369110.1APOA1, APOE, APOA2
23collagen catabolic processGO:03057410.1MMP1, MMP7, MMP8
24cellular response to tumor necrosis factorGO:07135610.0APOB, CCL2, CCL5
25receptor-mediated endocytosisGO:00689810.0VLDLR, LPA, APOB, APOE
26organ regenerationGO:03110010.0APOA2, APOA1, CCL2
27extracellular matrix disassemblyGO:02261710.0MMP1, MMP7, MMP8
28cellular response to lipopolysaccharideGO:07122210.0CCL2, TNFSF4, CD14
29cellular response to interleukin-1GO:07134710.0APOE, CCL2, CCL5
30cholesterol effluxGO:0333449.9APOB, APOA2, APOE, APOA1
31leukocyte migrationGO:0509009.9APOB, MMP1, THBD, SELE
32cholesterol homeostasisGO:0426329.9APOA1, APOE, APOA2, APOB
33phototransduction, visible lightGO:0076039.9APOB, APOA2, APOE, APOA1
34macrophage chemotaxisGO:0482469.8CCL5, CCL2
35lipoprotein metabolic processGO:0421579.7APOA1, APOE, APOA2, APOB, LPA
36cellular calcium ion homeostasisGO:0068749.7CCL5, CCL2, APOE
37negative regulation of blood coagulationGO:0301959.6APOE, THBD
38response to drugGO:0424939.5CCL2, APOA1, APOA2, MMP7
39cholesterol metabolic processGO:0082039.4PON1, VLDLR, APOB, APOA2, APOE, APOA1
40inflammatory responseGO:0069549.4SELE, CD14, CCL2, CCL5
41blood coagulationGO:0075969.3APOA1, APOB, F10, MMP1, THBD, SELE
42proteolysisGO:0065089.3LPA, F10, MMP8, MMP7, MMP1, ACE

Molecular functions related to Carotid Artery Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:03419010.1APOA2, APOA1
2high-density lipoprotein particle receptor bindingGO:07065310.1APOA2, APOA1
3low-density lipoprotein particle receptor bindingGO:05075010.0APOB, APOE
4lipase inhibitor activityGO:0551029.9APOA2, APOA1
5phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.9APOA1, APOE, APOA2
6cholesterol transporter activityGO:0171279.7APOB, APOA2, APOE, APOA1
7high-density lipoprotein particle bindingGO:0080359.7APOA2, APOA1
8heparin bindingGO:0082019.6CCL2, APOE, APOB, LPA
9phospholipid bindingGO:0055439.2APOA1, APOE, APOA2, APOB, F10, PON1
10calcium ion bindingGO:0055099.1F10, VLDLR, PON1, MMP8, MMP1, THBD

Products for genes affiliated with Carotid Artery Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carotid Artery Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet