MCID: CRT004
MIFTS: 47

Carotid Artery Thrombosis malady

Cardiovascular diseases, Blood diseases categories

Summaries for Carotid Artery Thrombosis

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34MalaCards
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MalaCards: Carotid Artery Thrombosis is related to hypercholesterolemia and diabetes mellitus. An important gene associated with Carotid Artery Thrombosis is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are TGF Beta Signaling Pathway and Collagen biosynthesis and modifying enzymes. The compounds dabigatran and efegatran have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related mouse phenotypes are tumorigenesis and vision/eye.

Aliases & Classifications for Carotid Artery Thrombosis

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

carotid artery thrombosis 9 46 63


External Ids:

Disease Ontology9 DOID:3410
SNOMED-CT59 195181000, 86003009
MeSH36 D002341

Related Diseases for Carotid Artery Thrombosis

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18GeneCards, 19GeneDecks
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Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1hypercholesterolemia30.2NOS3, F10, SERPINE1, COG2
2diabetes mellitus30.1F10, SERPINE1, COG2, SERPINC1, NOS3
3myocardial infarction30.0NOS3, COG2, F3, SERPINC1, F10, SERPINE1
4head injury10.4
5rubella10.2
6myelitis10.2
7pharyngitis10.2
8neuronitis10.2
9type 1 diabetes mellitus10.2
10horner's syndrome10.2
11cerebritis10.2
12familial hypercholesterolemia10.2
13aspergillosis10.2
14encephalitis10.2
15endophthalmitis10.2
16nephrotic syndrome10.2
17neuritis10.2
18optic neuritis10.2
19carotidynia10.2
20headache10.2
21endotheliitis10.2
22sagittal sinus thrombosis10.1SERPINC1
23dysfibrinogenemia10.1SERPINC1
24meningococcemia10.1SERPINC1
25purpura fulminans10.1SERPINC1
26placental abruption10.1SERPINC1
27purpura10.1SERPINC1
28eclampsia10.1SERPINC1
29thrombotic thrombocytopenic purpura, acquired10.1SERPINE1, F3
30factor x deficiency10.1F3, F10
31hemarthrosis10.1F10, F3
32afibrinogenemia10.1F3, F10
33hemophilia b10.1F10, F3
34glanzmann's thrombasthenia10.1F10, F3
35intracranial thrombosis10.1SERPINC1, F3
36blood platelet disease10.1F3, SERPINC1
37glucose intolerance10.1SERPINE1, COG2
38factor xii deficiency10.1F3, SERPINC1
39hepatic vein thrombosis10.1SERPINC1, SERPINE1
40severe pre-eclampsia10.1SERPINE1, SERPINC1
41hellp syndrome10.0SERPINE1, SERPINC1
42leukopenia10.0CSF2, F3
43protein c deficiency10.0SERPINE1, SERPINC1
44respiratory failure10.0F3, SERPINC1
45antithrombin iii deficiency10.0SERPINC1, F10
46chronic granulomatous disease10.0IFNG, CSF2
47pulmonary sarcoidosis10.0IFNG, CSF2
48galactosemia10.0SERPINC1, F3
49factor vii deficiency10.0CSF2, IFNG
50hypertriglyceridemia10.0SERPINE1, COG2

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to carotid artery thrombosis

Symptoms for Carotid Artery Thrombosis

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Drugs & Therapeutics for Carotid Artery Thrombosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Carotid Artery Thrombosis

Search CenterWatch for Carotid Artery Thrombosis

Genetic Tests for Carotid Artery Thrombosis

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Anatomical Context for Carotid Artery Thrombosis

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34MalaCards
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MalaCards organs/tissues related to Carotid Artery Thrombosis:

34
Brain, Liver, Endothelial

Animal Models for Carotid Artery Thrombosis or affiliated genes

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38MGI
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Publications for Carotid Artery Thrombosis

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53PubMed
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Articles related to Carotid Artery Thrombosis:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Symptomatic internal carotid artery thrombosis in acute carbon monoxide intoxication. (24388067)
2013
2
Spontaneous free floating carotid artery thrombosis. (23749854)
2013
3
Asymptomatic external carotid artery thrombosis in acute stroke. (22549811)
2012
4
Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. (21479193)
2011
5
Internal carotid artery thrombosis after blunt trauma--salvage therapy with the penumbra thrombectomy system. (20349674)
2010
6
Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. (20694780)
2010
7
Carotid artery thrombosis and delayed stroke associated with the use of a shoulder belt in a teenager. (19635289)
2009
8
Images from headache: cluster-like headache associated with intra-cavernous carotid artery thrombosis. (18808501)
2008
9
Acute carotid artery thrombosis: description of 12 surgically treated cases. (15714361)
2005
10
Prevention of carotid artery thrombosis after oral administration of the glycoprotein IIb/IIIa antagonist CRL42796. (12827029)
2003
11
Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture. (12890856)
2003
12
Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. (12876627)
2003
13
Endothelial nitric oxide synthase pathophysiology after nonocclusive common carotid artery thrombosis in rats. (11973434)
2002
14
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis. (10688985)
2000
15
Delayed bilateral internal carotid artery thrombosis following accidental strangulation. (10823110)
2000
16
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis. (10991981)
2000
17
Internal carotid artery thrombosis and Horner's syndrome as complications of parapharyngeal abscess. (10388902)
1999
18
Traumatic internal carotid artery thrombosis after impalement injury. (9419147)
1997
19
On-table diagnosis of incipient carotid artery thrombosis during carotid endarterectomy by transcranial Doppler scanning. (7913141)
1994
20
Acute carotid artery thrombosis after neck irradiation. (7933034)
1994
21
Prevention of experimental carotid artery thrombosis by applaggin. (8246155)
1993
22
Transient platelet accumulation in the rat brain after common carotid artery thrombosis. An 111In-labeled platelet study. (8378958)
1993
23
Computed tomographic diagnosis of radiation-induced internal carotid artery thrombosis. (8457126)
1993
24
Serotonin release into plasma during common carotid artery thrombosis in rats. (1595108)
1992
25
Antithrombotic effects of the prostacyclin analogue naxaprostene after oral and intraduodenal application in rabbit carotid artery thrombosis. (1632291)
1992
26
Bilateral carotid artery thrombosis. (2802134)
1989
27
Internal carotid artery thrombosis: a complication of closed craniocervical trauma. (2695572)
1989
28
Maternal death from carotid artery thrombosis associated with the syndrome of hemolysis, elevated liver function, and low platelets. (2730743)
1989
29
Internal carotid artery thrombosis. (3830003)
1987
30
Prevention of experimental carotid artery thrombosis by magnetic vectoring of aspirin. (2887851)
1987
31
Carotid artery thrombosis associated with lupus anticoagulant. (3929417)
1985
32
Internal carotid artery thrombosis following soft palate injuries: a case report and review of 16 cases. (6390042)
1984
33
Internal carotid artery thrombosis presenting as catatonic stupor - case report. (21847298)
1983
34
Carotid artery thrombosis after elective mandibular and maxillary osteotomies. (7271163)
1981
35
Bilateral internal carotid artery thrombosis after closed head injury. (726960)
1978
36
Internal carotid artery thrombosis associated with a fracture. (277641)
1978
37
Internal carotid artery thrombosis following head and neck surgery. (591782)
1977
38
Bilateral internal carotid artery thrombosis. Prognosis and risk factors. (1146502)
1975
39
Internal carotid artery thrombosis secondary to closed head injury. (5434376)
1970
40
Traumatic internal carotid artery thrombosis in a child. (5434377)
1970
41
The collateral circulation via the ophthalmic artery in internal carotid artery thrombosis. (5803592)
1969
42
A clinical and radiological analysis of 77 patients with internal carotid artery thrombosis. (5583230)
1967
43
Juvenile bilateral carotid artery thrombosis. (4170404)
1966
44
The problem of internal carotid artery thrombosis. (13573002)
1958
45
Internal carotid artery thrombosis. (13520075)
1958
46
Complications in the surgery of internal carotid artery thrombosis. (13564270)
1958
47
Pulseless disease and carotid-artery thrombosis; surgical considerations. (13477371)
1957
48
Symposium on carotid artery thrombosis. (13404768)
1955-1957
49
Traumatic internal carotid artery thrombosis secondary to nonpenetrating injuries to the neck; a problem in the differential diagnosis of craniocerebral trauma. (12981571)
1952
50
Carotid artery thrombosis; report of eight cases due to trauma. (18864120)
1948

Variations for Carotid Artery Thrombosis

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Expression for genes affiliated with Carotid Artery Thrombosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for genes affiliated with Carotid Artery Thrombosis

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 55R&D Systems, 31KEGG
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Compounds for genes affiliated with Carotid Artery Thrombosis

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Sources:
52PharmGKB, 46Novoseek, 12DrugBank, 3BitterDB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1dabigatran52 4610.6SERPINC1, F3, F10
2efegatran469.6F3, SERPINC1, F10
3ecarin469.6SERPINC1, F3, F10
4nadroparin46 1210.6F10, SERPINC1, F3
5spectrozyme469.6F10, SERPINC1, F3
6danaparoid469.6F10, F3, SERPINC1
7rivaroxaban46 1210.6SERPINC1, F10, F3
8ximelagatran46 1210.6SERPINC1, F10, F3
9organon469.6F10, SERPINC1, F3
10tinzaparin46 1210.6SERPINC1, F3, F10
11heparinoids469.6F10, F3, SERPINC1
12p-amino benzamidine469.6F10, SERPINC1, SERPINE1
13fondaparinux469.6F10, SERPINC1, F3
14tranexamic acid46 1210.6SERPINE1, SERPINC1, F3
15ancrod469.6SERPINC1, SERPINE1, F10
16bivalirudin46 1210.6F3, SERPINC1, F10
17argatroban46 1210.6F3, SERPINC1, F10
18ppack469.5SERPINC1, F10, F3
19protamine sulfate469.5F10, F3, SERPINC1
20epsilon aminocaproic acid469.5SERPINC1, F3, SERPINE1
21tirofiban46 1210.5F10, F3, SERPINC1
22fucoidan469.5SERPINC1, F3, SERPINE1
23ticlopidine46 1210.4CSF2, F3, SERPINC1
24n(g)-nitro-l-arginine methyl ester469.4F3, SERPINE1, NOS3
25abciximab46 1210.3SERPINC1, F10, F3
26coumarin46 3 52 2512.3F10, F3, SERPINC1
27hirudin469.3F10, SERPINC1, F3, SERPINE1
28protamine469.2F10, SERPINC1, SERPINE1, F3
29desmopressin46 62 30 1212.2F3, SERPINC1, SERPINE1
30aprotinin46 1210.2F3, SERPINC1, SERPINE1, F10
31nomegestrol acetate469.1NOS3, COG2, SERPINC1
32clopidogrel46 52 25 1212.0NOS3, SERPINC1, F3, F10
33nitroglycerin46 1210.0F3, NOS3, COG2
34fluorescein46 129.9F3, SERPINC1, F10
35cyclophosphamide46 52 1210.9NOS3, CSF2, F3, SERPINE1
36citrate468.9SERPINC1, NOS3, F3, F10
37cerivastatin52 46 30 1211.9COG2, SERPINE1, NOS3
38prostacyclin468.8F3, SERPINC1, SERPINE1, NOS3
39endotoxin468.7SERPINE1, CSF2, IFNG, F3
40fibrinogen468.7F10, SERPINE1, SERPINC1, F3, COG2
4115-deoxy-delta-12,14-prostaglandin j2468.6CSF2, NOS3, IFNG, SERPINE1
42homocysteine46 259.5SERPINC1, F3, COG2, NOS3, SERPINE1
43heparin46 30 25 1211.3CSF2, F10, SERPINE1, COG2, SERPINC1, F3
44cycloheximide468.2F10, IFNG, F3, SERPINE1, CSF2
45actinomycin d468.2IFNG, F3, SERPINE1, CSF2, NOS3
46sb 20358046 628.9IFNG, NOS3, F3, SERPINE1, CSF2, F10
47estrogen467.9F10, NOS3, CSF2, COG2, SERPINC1, SERPINE1
48simvastatin46 52 62 30 25 1212.8SERPINE1, F10, IFNG, F3, COG2, NOS3
49aspirin46 52 30 2510.7SERPINC1, NOS3, CSF2, COG2, F3, SERPINE1
50vegf467.4IFNG, CSF2, F3, SERPINC1, SERPINE1, F10

GO Terms for genes affiliated with Carotid Artery Thrombosis

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17Gene Ontology
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Cellular components related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:0312339.6F3, F10
2extracellular regionGO:0055767.9CSF2, IFNG, SERPINC1, SERPINE1, F10
3extracellular spaceGO:0056157.7SERPINE1, SERPINC1, F3, IFNG, CSF2

Biological processes related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.7F3, F10
2positive regulation of protein kinase B signalingGO:0518979.7F3, F10
3positive regulation of interleukin-23 productionGO:0327479.3CSF2, IFNG
4negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.2NOS3, SERPINE1
5positive regulation of angiogenesisGO:0457669.0SERPINE1, F3, NOS3
6cellular response to lipopolysaccharideGO:0712228.9IFNG, SERPINE1, CSF2
7blood coagulationGO:0075968.4NOS3, F3, SERPINC1, SERPINE1, F10

Molecular functions related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:0055439.7F3, F10
2protease bindingGO:0020209.1F3, SERPINC1, SERPINE1
3protein bindingGO:0055156.9F10, SERPINE1, SERPINC1, F3, COG2, CSF2

Products for genes affiliated with Carotid Artery Thrombosis

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Sources for Carotid Artery Thrombosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet