MCID: CRT004
MIFTS: 45

Carotid Artery Thrombosis malady

Blood diseases category

Summaries for Carotid Artery Thrombosis

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32MalaCards
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MalaCards: Carotid Artery Thrombosis is related to nephrotic syndrome and diabetes mellitus. An important gene associated with Carotid Artery Thrombosis is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds p-amino benzamidine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and liver, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Carotid Artery Thrombosis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

carotid artery thrombosis 8 44 60


External Ids:

Disease Ontology8 DOID:3410
SNOMED-CT56 86003009, 195181000
MeSH34 D002341

Related Diseases for Carotid Artery Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.2SERPINC1
2diabetes mellitus30.2COG2, F10, NOS3, SERPINE1, SERPINC1
3myocardial infarction30.1COG2, F10, F3, P2RY12, NOS3, SERPINE1
4carotid stenosis10.3
5rubella10.1
6myelitis10.1
7cerebritis10.1
8pharyngitis10.1
9neuronitis10.1
10type 1 diabetes mellitus10.1
11carotid artery occlusion10.1
12familial hypercholesterolemia10.1
13horner's syndrome10.1
14aspergillosis10.1
15carotid artery disease10.1
16encephalitis10.1
17endophthalmitis10.1
18neuritis10.1
19optic neuritis10.1
20von willebrand's disease10.0F3
21herpes simplex10.0F10
22polycystic ovary syndrome10.0SERPINE1
23viral hepatitis10.0F10
24amyloidosis10.0F10
25hepatitis10.0F10
26purpura10.0SERPINC1
27astrocytoma10.0P2RY12
28cerebrovascular disease10.0COG2
29hepatocellular carcinoma10.0F10
30eclampsia10.0SERPINC1
31portal vein thrombosis10.0SERPINC1
32hypothyroidism10.0COG2
33sickle cell disease10.0NOS3
34retinal vein occlusion10.0SERPINC1
35portal hypertension10.0NOS3
36sagittal sinus thrombosis10.0SERPINC1
37uremia10.0NOS3
38schistosomiasis10.0IFNG
39malaria10.0IFNG
40multiple sclerosis10.0IFNG
41purpura fulminans10.0SERPINC1
42dysfibrinogenemia10.0SERPINC1
43meningococcemia10.0SERPINC1
44hepatitis b10.0IFNG
45prostate cancer10.0NOS3
46lupus erythematosus10.0SERPINC1, F3
47hepatitis c10.0IFNG
48factor x deficiency10.0F3, F10
49respiratory failure10.0SERPINC1, F3
50hemarthrosis10.0F3, F10

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to carotid artery thrombosis

Clinical Features for Carotid Artery Thrombosis

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Drugs & Therapeutics for Carotid Artery Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Carotid Artery Thrombosis

Drug clinical trials:

Search ClinicalTrials for Carotid Artery Thrombosis

Search NIH Clinical Center for Carotid Artery Thrombosis

Search CenterWatch for Carotid Artery Thrombosis

Genetic Tests for Carotid Artery Thrombosis

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Anatomical Context for Carotid Artery Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Carotid Artery Thrombosis:

32
Bone, Brain, Liver, Endothelial

Animal Models for Carotid Artery Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0GCNT2
2MP:001077110.0GCNT2
3MP:00053857.2IFNG, CSF2, F10, F3, NOS3, SERPINE1
4MP:00053976.8GCNT2, IFNG, CSF2, F3, P2RY12, NOS3
5MP:00053876.7GCNT2, IFNG, CSF2, F3, NOS3, SERPINE1
6MP:00107686.5COG2, IFNG, CSF2, F10, F3, NOS3
7MP:00053766.5SERPINC1, GCNT2, IFNG, CSF2, F10, F3

Publications for Carotid Artery Thrombosis

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50PubMed
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Articles related to Carotid Artery Thrombosis:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Spontaneous free floating carotid artery thrombosis. (23749854)
2013
2
Internal carotid artery thrombosis due to an unusual soft palate injury in a child. (24317280)
2013
3
Immediate surgery for acute internal carotid artery dissection and thrombosis during filter deployment prior to stenting: a case report. (23579380)
2013
4
Rare case of carotid artery occlusion due to thrombosis of a giant cerebral aneurysm: the role of cerebral revascularization. (22311227)
2012
5
Asymptomatic external carotid artery thrombosis in acute stroke. (22549811)
2012
6
Carotid artery thrombosis in a child with membranous nephropathy associated with factor V Leiden mutation. (22830551)
2012
7
Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. (21479193)
2011
8
Images from headache: cluster-like headache associated with intra-cavernous carotid artery thrombosis. (18808501)
2008
9
Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits. (15956136)
2005
10
Hypopituitarism and amenorrhea-galactorrhea syndrome caused by thrombosis of both internal carotid artery and giant intrasellar aneurysm: case report. (15122453)
2004
11
Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture. (12890856)
2003
12
Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. (12876627)
2003
13
Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis. (14556079)
2003
14
Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. (14675104)
2003
15
Internal carotid artery occlusion in a patient with malignant peritoneal mesothelioma: is it a sign of malignancy-related thrombosis? (10768615)
2000
16
A porcine model of carotid artery thrombosis for thrombolytic therapy and angioplasty: application of PTFE graft-induced stenosis. (10883961)
2000
17
Noncollagenous bone matrix proteins, calcification, and thrombosis in carotid artery atherosclerosis. (10446063)
1999
18
Rhinosino-orbital mucormycosis causing cavernous sinus thrombosis and internal carotid artery occlusion: radiological findings in a patient with treatment failure. (10561981)
1999
19
An alternative model of carotid artery thrombosis in rats. (10605956)
1999
20
MR demonstration of a giant cavernous carotid aneurysm with occlusion of the contralateral intracranial carotid artery: an unusual complication of cavernous sinus thrombosis. (9808317)
1998
21
Antithrombotic activity of a 2-kDa heparin fragment in an experimental model of carotid artery thrombosis in rats. (8794992)
1996
22
Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis. (8635271)
1996
23
Internal carotid artery thrombosis in a child secondary to intraoral trauma. (8842915)
1996
24
Nonocclusive common carotid artery thrombosis in the rat results in reversible sensorimotor and cognitive behavioral deficits. (7491661)
1995
25
On-table diagnosis of incipient carotid artery thrombosis during carotid endarterectomy by transcranial Doppler scanning. (7913141)
1994
26
Diagnosis of early postoperative carotid artery thrombosis determined by transcranial Doppler scanning. (7990175)
1994
27
Effect of different glycosaminoglycans in a guinea-pig carotid artery thrombosis model. (7831678)
1994
28
Prevention of experimental carotid artery thrombosis by applaggin. (8246155)
1993
29
Transient platelet accumulation in the rat brain after common carotid artery thrombosis. An 111In-labeled platelet study. (8378958)
1993
30
Microvascular and neuronal consequences of common carotid artery thrombosis and platelet embolization in rats. (8355024)
1993
31
Experimental model of carotid artery thrombosis in rats and the thrombolytic activity of YM866, a novel modified tissue-type plasminogen activator. (8283822)
1993
32
Bilateral carotid artery thrombosis in a young man. (8464104)
1993
33
Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. (1605806)
1992
34
Internal carotid artery thrombosis after blunt maxillofacial trauma. (1923436)
1991
35
Carotid artery thrombosis associated with lupus anticoagulant. (3929417)
1985
36
Internal carotid artery thrombosis presenting as catatonic stupor - case report. (21847298)
1983
37
Internal carotid artery thrombosis associated with a fracture. (277641)
1978
38
Internal carotid artery thrombosis following head and neck surgery. (591782)
1977
39
Aseptic cavernous sinus thrombosis after internal carotid arterial occlusion in polycythaemia vera. (932749)
1976
40
The collateral circulation via the ophthalmic artery in internal carotid artery thrombosis. (5803592)
1969
41
Intracranial thrombosis of the internal carotid artery after closed head injury. (5360046)
1969
42
Carotid artery thrombosis in non-penetrating injuries of the head and neck. (5823284)
1969
43
Evaluation of ophthalmodynamometric and angiographic findings in patients with internal carotid artery thrombosis. (13812943)
1960
44
Carotid Artery Thrombosis. (20326314)
1960
45
The problem of internal carotid artery thrombosis. (13573002)
1958
46
Complications in the surgery of internal carotid artery thrombosis. (13564270)
1958
47
Internal carotid artery thrombosis; a case report. (13380577)
1956
48
Symposium on carotid artery thrombosis. (13404768)
1955-1957
49
Stroke resulting from internal carotid artery thrombosis in the neck. (13011042)
1953
50
Traumatic internal carotid artery thrombosis secondary to nonpenetrating injuries to the neck; a problem in the differential diagnosis of craniocerebral trauma. (12981571)
1952

Genetic Variations for Carotid Artery Thrombosis

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Expression for genes affiliated with Carotid Artery Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for genes affiliated with Carotid Artery Thrombosis

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Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8F3, F10
2
Hide members
9.4SERPINC1, F3, F10
3
Hide members
9.4NOS3, P2RY12, F3
4
Hide members
9.1SERPINC1, SERPINE1, F3, F10
5
Hide members
9.1F10, F3, SERPINE1, SERPINC1
6
Hide members
9.1F10, F3, SERPINE1, SERPINC1
79.0CSF2, IFNG
8
Hide members
9.0IFNG, F3, SERPINE1
99.0CSF2, IFNG
108.9SERPINE1, NOS3, IFNG

Compounds for genes affiliated with Carotid Artery Thrombosis

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1p-amino benzamidine4410.5SERPINE1
2estrogen4410.1COG2
3endotoxin4410.0F3, SERPINE1
4n(g)-nitro-l-arginine methyl ester4410.0F3, NOS3
5dabigatran449.8F10, SERPINC1, F3
6efegatran449.8F10, F3, SERPINC1
7ecarin449.8F3, F10, SERPINC1
8nadroparin44 1110.8SERPINC1, F3, F10
9spectrozyme449.8F10, SERPINC1, F3
10danaparoid449.8SERPINC1, F3, F10
11organon449.8F3, SERPINC1, F10
12rivaroxaban44 1110.8SERPINC1, F10, F3
13tinzaparin44 1110.8SERPINC1, F3, F10
14celite449.8SERPINC1, F3
15ximelagatran44 1110.8F10, SERPINC1, F3
16tranexamic acid44 1110.8SERPINE1, F3, SERPINC1
17heparinoids449.8F3, SERPINC1, F10
18fondaparinux449.7F10, F3, SERPINC1
19ancrod449.7SERPINE1, SERPINC1, F10
20bivalirudin44 1110.7F10, F3, SERPINC1
21argatroban44 1110.7SERPINC1, F3, F10
22epsilon aminocaproic acid449.7F3, SERPINC1, SERPINE1
23protamine sulfate449.7F3, SERPINC1, F10
24Fondaparinux sodium119.7SERPINC1, F10
25fucoidan449.7SERPINC1, SERPINE1, F3
26heparin pentasaccharide449.6SERPINC1, F10
27anisodamine449.6SERPINE1, F3
28ppack449.5F10, F3, P2RY12, SERPINC1
29tirofiban44 1110.5P2RY12, F3, F10, SERPINC1
30hirudin449.5F10, F3, SERPINE1, SERPINC1
31abciximab44 1110.5P2RY12, F3, F10, SERPINC1
32protamine449.5SERPINC1, SERPINE1, F3, F10
33nomegestrol acetate449.4NOS3, COG2, SERPINC1
34aprotinin44 1110.4SERPINC1, SERPINE1, F3, F10
35ticlopidine44 1110.2F3, CSF2, P2RY12, SERPINC1
36citrate449.2F10, F3, SERPINC1, NOS3
37heparin44 28 11 2412.1COG2, P2RY12, CSF2, F10
38clopidogrel49 44 11 2412.0F10, SERPINC1, NOS3, F3, P2RY12
39heparan sulfate44 2410.0GCNT2, SERPINC1, SERPINE1, F10
40cyclophosphamide44 49 1111.0NOS3, CSF2, F3, SERPINE1
41homocysteine44 249.9SERPINE1, SERPINC1, NOS3, F3, COG2
42fibrinogen448.6F10, F3, P2RY12, SERPINE1, SERPINC1, COG2
4315-deoxy-delta-12,14-prostaglandin j2448.6CSF2, IFNG, SERPINE1, NOS3
44polysaccharide448.5SERPINC1, GCNT2, CSF2, F10, F3
45actinomycin d448.2NOS3, F3, IFNG, CSF2, SERPINE1
46simvastatin44 49 59 28 11 2413.1SERPINE1, NOS3, IFNG, F3, F10, COG2
47sb 20358044 599.0SERPINE1, NOS3, F3, F10, CSF2, IFNG
48vegf447.6SERPINC1, SERPINE1, IFNG, CSF2, F10, F3
49aspirin44 49 28 2410.6CSF2, NOS3, F3, F10, COG2, P2RY12
50retinoic acid44 248.5SERPINE1, NOS3, F3, CSF2, IFNG, GCNT2

GO Terms for genes affiliated with Carotid Artery Thrombosis

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16Gene Ontology
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Cellular components related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to external side of plasma membraneGO:0312339.5F3, F10
2extracellular spaceGO:0056158.0SERPINC1, SERPINE1, F3, CSF2, IFNG

Biological processes related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.8F10, F3
2negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7SERPINE1, NOS3
3positive regulation of interleukin-23 productionGO:0327479.1IFNG, CSF2
4positive regulation of angiogenesisGO:0457669.1F3, NOS3, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.6SERPINE1, CSF2, IFNG
6blood coagulationGO:0075968.4SERPINC1, SERPINE1, NOS3, P2RY12, F3, F10

Molecular functions related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4SERPINC1, SERPINE1, F3

Products for genes affiliated with Carotid Artery Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Carotid Artery Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet