MCID: CRT004
MIFTS: 40

Carotid Artery Thrombosis malady

Blood category

Summaries for Carotid Artery Thrombosis

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33MalaCards
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MalaCards: Carotid Artery Thrombosis is related to venous thrombosis and hypercholesterolemia. An important gene associated with Carotid Artery Thrombosis is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds p-amino benzamidine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and endothelial, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Carotid Artery Thrombosis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

carotid artery thrombosis 8 45 61


External Ids:

Disease Ontology8 DOID:3410
SNOMED-CT57 86003009, 195181000
MeSH35 D002341

Related Diseases for Carotid Artery Thrombosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1venous thrombosis30.2SERPINC1, SERPINE1, F3, F10
2hypercholesterolemia30.2SERPINE1, NOS3, F10, COG2
3head injury10.4
4carotid stenosis10.3
5rubella10.2
6myelitis10.2
7carotid artery occlusion10.2
8n syndrome10.2
9familial hypercholesterolemia10.2
10horner's syndrome10.2
11aspergillosis10.2
12carotidynia10.2
13cluster headache10.2
14headache10.2
15von willebrand's disease10.0F3
16herpes simplex10.0F10
17polycystic ovary syndrome10.0SERPINE1
18viral hepatitis10.0F10
19amyloidosis10.0F10
20hepatitis10.0F10
21purpura10.0SERPINC1
22astrocytoma10.0P2RY12
23cerebrovascular disease10.0COG2
24hepatocellular carcinoma10.0F10
25eclampsia10.0SERPINC1
26nephrotic syndrome10.0SERPINC1
27portal vein thrombosis10.0SERPINC1
28hypothyroidism10.0COG2
29sickle cell disease10.0NOS3
30retinal vein occlusion10.0SERPINC1
31portal hypertension10.0NOS3
32sagittal sinus thrombosis10.0SERPINC1
33uremia10.0NOS3
34schistosomiasis10.0IFNG
35malaria10.0IFNG
36multiple sclerosis10.0IFNG
37purpura fulminans10.0SERPINC1
38dysfibrinogenemia10.0SERPINC1
39meningococcemia10.0SERPINC1
40hepatitis b10.0IFNG
41prostate cancer10.0NOS3
42lupus erythematosus10.0SERPINC1, F3
43hepatitis c10.0IFNG
44factor x deficiency10.0F3, F10
45respiratory failure10.0SERPINC1, F3
46hemarthrosis10.0F3, F10
47acquired immunodeficiency syndrome10.0CSF2
48protein c deficiency10.0SERPINC1, SERPINE1
49hepatic vein thrombosis10.0SERPINC1, SERPINE1
50thrombotic thrombocytopenic purpura, acquired10.0SERPINE1, F3

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to carotid artery thrombosis

Clinical Features for Carotid Artery Thrombosis

Drugs & Therapeutics for Carotid Artery Thrombosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Carotid Artery Thrombosis

Drug clinical trials:

Search ClinicalTrials for Carotid Artery Thrombosis

Search NIH Clinical Center for Carotid Artery Thrombosis

Search CenterWatch for Carotid Artery Thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Carotid Artery Thrombosis:

33
Liver, Brain, Endothelial

Animal Models for Carotid Artery Thrombosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Carotid Artery Thrombosis

Sources:
51PubMed
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Articles related to Carotid Artery Thrombosis:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Symptomatic internal carotid artery thrombosis in acute carbon monoxide intoxication. (24388067)
2013
2
Carotid artery thrombosis treated with catheter intervention using proximal occlusion and flow reversal. (23645056)
2013
3
Preparation of thrombosis-targeted lipid microbubbles and determination of rabbit carotid artery thrombosis by microbubbles ultrasonogaphy. (23392725)
2013
4
Septic cavernous sinus thrombosis complicated by occlusion of the internal carotid artery and multiple embolic strokes after surgery of an anorectal abscess: a clinical chameleon. (22931741)
2012
5
A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits. (21158497)
2011
6
Internal carotid artery thrombosis after blunt trauma--salvage therapy with the penumbra thrombectomy system. (20349674)
2010
7
Effect of a synthetic peptide corresponding to residues 313 to 320 of the alphaIIb subunit of the human platelet integrin alphaIIbbeta3 on carotid artery thrombosis in rabbits. (19244095)
2009
8
Septic cavernous sinus thrombosis complicated by narrowing of the internal carotid artery, subarachnoid abscess and multiple pulmonary septic emboli. (17380002)
2007
9
Invasive aspergillosis and thrombosis of carotid artery. (16599286)
2006
10
Acute carotid artery thrombosis: description of 12 surgically treated cases. (15714361)
2005
11
Hypopituitarism and amenorrhea-galactorrhea syndrome caused by thrombosis of both internal carotid artery and giant intrasellar aneurysm: case report. (15122453)
2004
12
Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. (12876627)
2003
13
Spontaneous thrombosis of a giant intracavernous internal carotid artery aneurysm and ipsilateral internal carotid artery occlusion. (12450106)
2002
14
Visual disturbance due to carotid artery thrombosis in a patient with familial hypercholesterolemia; response to surgical thrombotectomy. (11393415)
2001
15
Delayed bilateral internal carotid artery thrombosis following accidental strangulation. (10823110)
2000
16
Internal carotid artery occlusion in a patient with malignant peritoneal mesothelioma: is it a sign of malignancy-related thrombosis? (10768615)
2000
17
S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. (11127876)
2000
18
The role of oculopneumoplethysmography in detecting acute carotid artery thrombosis in patients with neurologic deficits after carotid endarterectomy. (10875996)
2000
19
Internal carotid artery thrombosis and Horner's syndrome as complications of parapharyngeal abscess. (10388902)
1999
20
Ischemic stroke due to transient thrombosis of the internal carotid artery in a patient with combined antiphospholipid syndrome and factor V Leiden. (10569313)
1999
21
Prevention of carotid artery thrombosis by oral platelet GPIIb/IIIa antagonist in dogs. (9099204)
1997
22
Coexistence of cerebral venous sinus and internal carotid artery thrombosis associated with exogenous sex hormones. A case report. (8638876)
1996
23
In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. (8650721)
1996
24
On-table diagnosis of incipient carotid artery thrombosis during carotid endarterectomy by transcranial Doppler scanning. (7913141)
1994
25
Acute carotid artery thrombosis after neck irradiation. (7933034)
1994
26
Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis. (7955202)
1994
27
Prevention of experimental carotid artery thrombosis by applaggin. (8246155)
1993
28
Internal carotid artery thrombosis following manual strangulation. (8429772)
1993
29
Serotonin release into plasma during common carotid artery thrombosis in rats. (1595108)
1992
30
Antithrombotic effects of the prostacyclin analogue naxaprostene after oral and intraduodenal application in rabbit carotid artery thrombosis. (1632291)
1992
31
Hemodynamic consequences of common carotid artery thrombosis and thrombogenically activated blood in rats. (1939389)
1991
32
Bilateral carotid artery thrombosis. (2802134)
1989
33
Internal carotid artery thrombosis: a complication of closed craniocervical trauma. (2695572)
1989
34
Maternal death from carotid artery thrombosis associated with the syndrome of hemolysis, elevated liver function, and low platelets. (2730743)
1989
35
Internal carotid artery thrombosis. (3830003)
1987
36
Disseminated aspergillosis. Aspergillus endophthalmitis, optic nerve infarction, and carotid artery thrombosis. (1147836)
1975
37
Carotid artery thrombosis, encephalitis, myelitis and optic neuritis associated with rubella virus infections. (1218369)
1975
38
Rhincerebral phycomycosis and internal carotid artery thrombosis. (1122191)
1975
39
Internal carotid artery thrombosis following head injury in a 17-month-old child. (4646430)
1972
40
Internal carotid artery thrombosis secondary to closed head injury. (5434376)
1970
41
Intracranial thrombosis of the internal carotid artery after closed head injury. (5360046)
1969
42
Internal carotid artery thrombosis secondary to closed craniocervical trauma. (5635423)
1968
43
Combined use of fibrinolysin and endarterectomy. Results in stenosis with recent carotid artery thrombosis. (13889682)
1961
44
Carotid artery thrombosis in persons fifteen years of age or younger. (13672788)
1959
45
Ophthalmodynamometry and carotid artery thrombosis. (13637162)
1959
46
Internal carotid artery thrombosis. (13520075)
1958
47
Pulseless disease and carotid-artery thrombosis; surgical considerations. (13477371)
1957
48
Collateral circulation of the external carotid artery and the internal carotid artery through the ophthalmic artery in cases of internal carotid artery thrombosis; report of five cases. (13273646)
1955
49
Arteriographic demonstration of collateral circulation through ophthalmic artery in internal carotid artery thrombosis; report of two cases. (13184347)
1954
50
Carotid artery thrombosis; report of eight cases due to trauma. (18864120)
1948

Genetic Variations for Carotid Artery Thrombosis

Expression for genes affiliated with Carotid Artery Thrombosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for genes affiliated with Carotid Artery Thrombosis

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8F3, F10
2
Hide members
9.4SERPINC1, F3, F10
3
Hide members
9.4NOS3, P2RY12, F3
4
Hide members
9.1SERPINC1, SERPINE1, F3, F10
5
Hide members
9.1F10, F3, SERPINE1, SERPINC1
6
Hide members
9.1F10, F3, SERPINE1, SERPINC1
79.0CSF2, IFNG
8
Hide members
9.0IFNG, F3, SERPINE1
99.0CSF2, IFNG
108.9SERPINE1, NOS3, IFNG

Compounds for genes affiliated with Carotid Artery Thrombosis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1p-amino benzamidine4510.5SERPINE1
2estrogen4510.1COG2
3endotoxin4510.0F3, SERPINE1
4n(g)-nitro-l-arginine methyl ester4510.0F3, NOS3
5dabigatran459.8F10, SERPINC1, F3
6efegatran459.8F10, F3, SERPINC1
7ecarin459.8F3, F10, SERPINC1
8nadroparin45 1110.8SERPINC1, F3, F10
9spectrozyme459.8F10, SERPINC1, F3
10danaparoid459.8SERPINC1, F3, F10
11organon459.8F3, SERPINC1, F10
12rivaroxaban45 1110.8SERPINC1, F10, F3
13tinzaparin45 1110.8SERPINC1, F3, F10
14celite459.8SERPINC1, F3
15ximelagatran45 1110.8F10, SERPINC1, F3
16tranexamic acid45 1110.8SERPINE1, F3, SERPINC1
17heparinoids459.8F3, SERPINC1, F10
18fondaparinux459.7F10, F3, SERPINC1
19ancrod459.7SERPINE1, SERPINC1, F10
20bivalirudin45 1110.7F10, F3, SERPINC1
21argatroban45 1110.7SERPINC1, F3, F10
22epsilon aminocaproic acid459.7F3, SERPINC1, SERPINE1
23protamine sulfate459.7F3, SERPINC1, F10
24Fondaparinux sodium119.7SERPINC1, F10
25fucoidan459.7SERPINC1, SERPINE1, F3
26heparin pentasaccharide459.6SERPINC1, F10
27anisodamine459.6SERPINE1, F3
28ppack459.5F10, F3, P2RY12, SERPINC1
29tirofiban45 1110.5P2RY12, F3, F10, SERPINC1
30hirudin459.5F10, F3, SERPINE1, SERPINC1
31abciximab45 1110.5P2RY12, F3, F10, SERPINC1
32protamine459.5SERPINC1, SERPINE1, F3, F10
33nomegestrol acetate459.4NOS3, COG2, SERPINC1
34aprotinin45 1110.4SERPINC1, SERPINE1, F3, F10
35ticlopidine45 1110.2F3, CSF2, P2RY12, SERPINC1
36citrate459.2F10, F3, SERPINC1, NOS3
37heparin45 29 11 2412.1COG2, P2RY12, CSF2, F10
38clopidogrel50 45 11 2412.0F10, SERPINC1, NOS3, F3, P2RY12
39heparan sulfate45 2410.0GCNT2, SERPINC1, SERPINE1, F10
40cyclophosphamide45 50 1111.0NOS3, CSF2, F3, SERPINE1
41homocysteine45 249.9SERPINE1, SERPINC1, NOS3, F3, COG2
42fibrinogen458.6F10, F3, P2RY12, SERPINE1, SERPINC1, COG2
4315-deoxy-delta-12,14-prostaglandin j2458.6CSF2, IFNG, SERPINE1, NOS3
44polysaccharide458.5SERPINC1, GCNT2, CSF2, F10, F3
45actinomycin d458.2NOS3, F3, IFNG, CSF2, SERPINE1
46simvastatin45 50 60 29 11 2413.1SERPINE1, NOS3, IFNG, F3, F10, COG2
47sb 20358045 609.0SERPINE1, NOS3, F3, F10, CSF2, IFNG
48vegf457.6SERPINC1, SERPINE1, IFNG, CSF2, F10, F3
49aspirin45 50 29 2410.6CSF2, NOS3, F3, F10, COG2, P2RY12
50retinoic acid45 248.5SERPINE1, NOS3, F3, CSF2, IFNG, GCNT2

GO Terms for genes affiliated with Carotid Artery Thrombosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to external side of plasma membraneGO:0312339.5F3, F10
2extracellular spaceGO:0056158.0SERPINC1, SERPINE1, F3, CSF2, IFNG

Biological processes related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.8F10, F3
2negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7SERPINE1, NOS3
3positive regulation of interleukin-23 productionGO:0327479.1IFNG, CSF2
4positive regulation of angiogenesisGO:0457669.1F3, NOS3, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.6SERPINE1, CSF2, IFNG
6blood coagulationGO:0075968.4SERPINC1, SERPINE1, NOS3, P2RY12, F3, F10

Molecular functions related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4SERPINC1, SERPINE1, F3

Products for genes affiliated with Carotid Artery Thrombosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carotid Artery Thrombosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet