MCID: CRT004
MIFTS: 37

Carotid Artery Thrombosis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Carotid Artery Thrombosis

MalaCards integrated aliases for Carotid Artery Thrombosis:

Name: Carotid Artery Thrombosis 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3410
MeSH 41 D002341
SNOMED-CT 64 195181000 86003009
UMLS 69 C0007274

Summaries for Carotid Artery Thrombosis

MalaCards based summary : Carotid Artery Thrombosis is related to thrombosis and myocardial infarction. An important gene associated with Carotid Artery Thrombosis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include endothelial, liver and brain, and related phenotypes are Increased Sindbis virus (SINV) infection and Increased Sindbis virus (SINV) infection

Related Diseases for Carotid Artery Thrombosis

Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 thrombosis 29.8 F10 F3 PLAT SELP SERPINE1
2 myocardial infarction 27.1 F10 F3 ITGA2B NOS3 PLAT SELP
3 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.8
4 acquired hemophilia 10.4 F10 F3
5 leech infestation 10.4 F10 F3
6 hemophilia a 10.3 F10 F3
7 vertebral artery occlusion 10.3 CSF2 F3
8 multicentric castleman disease 10.3 F3 IFNG
9 factor vii deficiency 10.3 F10 F3
10 blue toe syndrome 10.3 F3 SERPINE1
11 intracranial embolism 10.3 F3 PLAT
12 dysbaric osteonecrosis 10.3 F3 SERPINE1
13 catastrophic antiphospholipid syndrome 10.3 F3 SERPINE1
14 hemophilia b 10.3 F10 F3
15 trichosporonosis 10.3 CSF2 IFNG
16 marantic endocarditis 10.3 F3 PLAT
17 candida glabrata 10.3 CSF2 IFNG
18 intracranial vasospasm 10.3 NOS3 PLAT
19 hemorrhagic fever 10.3 F3 IFNG
20 cyclic neutropenia 10.3 CSF2 IFNG
21 human t-cell leukemia virus type 2 10.3 CSF2 IFNG
22 lemierre's syndrome 10.3 F3 SERPINE1
23 meconium aspiration syndrome 10.3 CSF2 IFNG
24 factor x deficiency 10.3 F10 F3
25 factor xiii deficiency 10.2 F3 SERPINE1
26 cytomegalovirus retinitis 10.2 CSF2 IFNG
27 buerger disease 10.2 NOS3 SERPINE1
28 shwartzman phenomenon 10.2 F3 SERPINE1
29 cryptococcal meningitis 10.2 CSF2 IFNG
30 inherited blood coagulation disease 10.2 F3 ITGA2B
31 vein disease 10.2 F3 PLAT
32 fibrinolytic defect 10.2 PLAT SERPINE1
33 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINE1
34 argentine hemorrhagic fever 10.2 PLAT SERPINE1
35 central serous chorioretinopathy 10.2 PLAT SERPINE1
36 afibrinogenemia 10.1 F10 F3
37 intracranial hypertension 10.1 F3 SERPINE1
38 acute cor pulmonale 10.1 PLAT SERPINE1
39 thrombophlebitis 10.1 PLAT SERPINE1
40 acute pulmonary heart disease 10.1 PLAT SERPINE1
41 paranasal sinus disease 10.1 IFNG SERPINE1
42 qualitative platelet defect 10.1 F3 SELP
43 monocytic leukemia 10.1 CSF2 F3 IFNG
44 platelet membrane fluidity 10.1 NOS3 SELP
45 hepatic vascular disease 10.1 F3 NOS3 SERPINE1
46 basilar artery occlusion 10.0 ITGA2B PLAT
47 blood coagulation disease 10.0 F3 ITGA2B
48 dengue hemorrhagic fever 10.0 F3 IFNG
49 head injury 10.0
50 angina pectoris 9.9 F3 PLAT SERPINE1

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to Carotid Artery Thrombosis

Symptoms & Phenotypes for Carotid Artery Thrombosis

GenomeRNAi Phenotypes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Sindbis virus (SINV) infection GR00310-A-1 9.1 CSF2 NOS3 PLAT
2 Increased Sindbis virus (SINV) infection GR00310-A-2 9.1 CSF2 NOS3 PLAT

MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 ITGA2B F10 NOS3 F3 IFNG PLAT
2 homeostasis/metabolism MP:0005376 10.09 ITGA2B F10 NOS3 F3 IFNG CSF2
3 hematopoietic system MP:0005397 10.06 ITGA2B NOS3 F3 IFNG CSF2 SELP
4 cellular MP:0005384 10.04 CSF2 ITGA2B NOS3 F3 IFNG PLAT
5 growth/size/body region MP:0005378 10.02 IFNG CSF2 F3 NOS3 PLAT SELP
6 immune system MP:0005387 10.01 ITGA2B NOS3 F3 IFNG CSF2 SELP
7 mortality/aging MP:0010768 9.92 F10 NOS3 F3 IFNG CSF2 PLAT
8 integument MP:0010771 9.85 F3 IFNG CSF2 PLAT SELP SERPINE1
9 renal/urinary system MP:0005367 9.65 CSF2 NOS3 IFNG SELP SERPINE1
10 reproductive system MP:0005389 9.63 CSF2 ITGA2B F10 NOS3 IFNG PLAT
11 respiratory system MP:0005388 9.5 NOS3 F3 IFNG PLAT CSF2 SELP
12 vision/eye MP:0005391 9.02 IFNG F3 NOS3 PLAT SELP

Drugs & Therapeutics for Carotid Artery Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy Completed NCT02341196

Search NIH Clinical Center for Carotid Artery Thrombosis

Cochrane evidence based reviews: carotid artery thrombosis

Genetic Tests for Carotid Artery Thrombosis

Anatomical Context for Carotid Artery Thrombosis

MalaCards organs/tissues related to Carotid Artery Thrombosis:

38
Endothelial, Liver, Brain

Publications for Carotid Artery Thrombosis

Articles related to Carotid Artery Thrombosis:

(show top 50) (show all 118)
# Title Authors Year
1
Simultaneous Occurrence of Deep Vein Thrombosis and Carotid Artery Thrombosis in Antiphospholipid Antibody Syndrome. ( 28479827 )
2017
2
Photoacoustic Imaging: A Novel Tool for Detecting Carotid Artery Thrombosis in Mice. ( 28689199 )
2017
3
PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances antia89thrombotic effect in a rat carotid artery thrombosis model. ( 28791355 )
2017
4
Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. ( 28487554 )
2017
5
The effect of pravastatin on carotid artery thrombosis in rats under the stimulus of C-reactive protein. ( 27416543 )
2016
6
The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. ( 26660522 )
2016
7
Direct penetrating and indirect neck trauma as a cause of internal carotid artery thrombosis and secondary ischemic stroke. ( 24748050 )
2014
8
Detection of activated platelets in a mouse model of carotid artery thrombosis with 18 F-labeled single-chain antibodies. ( 24440583 )
2014
9
Iridoid glycosides extracted from zhizi (fructus gardeniae) decrease collagen-induced platelet aggregation and reduce carotid artery thrombosis in an in vivo rat model. ( 24187877 )
2013
10
Carotid artery thrombosis treated with catheter intervention using proximal occlusion and flow reversal. ( 23645056 )
2013
11
Preparation of thrombosis-targeted lipid microbubbles and determination of rabbit carotid artery thrombosis by microbubbles ultrasonogaphy. ( 23392725 )
2013
12
Internal carotid artery thrombosis due to an unusual soft palate injury in a child. ( 24317280 )
2013
13
Spontaneous free floating carotid artery thrombosis. ( 23749854 )
2013
14
Symptomatic internal carotid artery thrombosis in acute carbon monoxide intoxication. ( 24388067 )
2013
15
Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury. ( 22945770 )
2012
16
Carotidynia with carotid arterial thrombosis. ( 23247948 )
2012
17
Asymptomatic external carotid artery thrombosis in acute stroke. ( 22549811 )
2012
18
Carotid artery thrombosis in a child with membranous nephropathy associated with factor V Leiden mutation. ( 22830551 )
2012
19
Internal carotid artery thrombosis and its evolution documented by computed tomography angiography. ( 24765384 )
2011
20
Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. ( 21479193 )
2011
21
A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits. ( 21158497 )
2011
22
Internal carotid artery thrombosis after blunt trauma--salvage therapy with the penumbra thrombectomy system. ( 20349674 )
2010
23
Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. ( 20694780 )
2010
24
Effect of a synthetic peptide corresponding to residues 313 to 320 of the alphaIIb subunit of the human platelet integrin alphaIIbbeta3 on carotid artery thrombosis in rabbits. ( 19244095 )
2009
25
Carotid artery thrombosis and delayed stroke associated with the use of a shoulder belt in a teenager. ( 19635289 )
2009
26
Effects of propyl gallate on carotid artery thrombosis and coagulation/fibrinolysis system in rats. ( 18568328 )
2008
27
Images from headache: cluster-like headache associated with intra-cavernous carotid artery thrombosis. ( 18808501 )
2008
28
Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature. ( 16390393 )
2005
29
Acute carotid artery thrombosis: description of 12 surgically treated cases. ( 15714361 )
2005
30
Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis. ( 14556079 )
2003
31
Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture. ( 12890856 )
2003
32
Differential effects of sodium nitroprusside and hydralazine in a rat model of topical FeCl3-induced carotid artery thrombosis. ( 14644081 )
2003
33
Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. ( 12876627 )
2003
34
Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. ( 14675104 )
2003
35
Prevention of carotid artery thrombosis after oral administration of the glycoprotein IIb/IIIa antagonist CRL42796. ( 12827029 )
2003
36
Endothelial nitric oxide synthase pathophysiology after nonocclusive common carotid artery thrombosis in rats. ( 11973434 )
2002
37
Visual disturbance due to carotid artery thrombosis in a patient with familial hypercholesterolemia; response to surgical thrombotectomy. ( 11393415 )
2001
38
S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. ( 11127876 )
2000
39
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis. ( 10991981 )
2000
40
Delayed bilateral internal carotid artery thrombosis following accidental strangulation. ( 10823110 )
2000
41
A porcine model of carotid artery thrombosis for thrombolytic therapy and angioplasty: application of PTFE graft-induced stenosis. ( 10883961 )
2000
42
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis. ( 10688985 )
2000
43
The role of oculopneumoplethysmography in detecting acute carotid artery thrombosis in patients with neurologic deficits after carotid endarterectomy. ( 10875996 )
2000
44
An alternative model of carotid artery thrombosis in rats. ( 10605956 )
1999
45
Internal carotid artery thrombosis and Horner's syndrome as complications of parapharyngeal abscess. ( 10388902 )
1999
46
Carotid artery thrombosis and stroke after blunt pharyngeal injury. ( 9095125 )
1997
47
Traumatic internal carotid artery thrombosis after impalement injury. ( 9419147 )
1997
48
Prevention of carotid artery thrombosis by oral platelet GPIIb/IIIa antagonist in dogs. ( 9099204 )
1997
49
Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis. ( 8635271 )
1996
50
In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. ( 8650721 )
1996

Variations for Carotid Artery Thrombosis

Expression for Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for Carotid Artery Thrombosis

Pathways related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 CSF2 F10 F3 ITGA2B NOS3 PLAT
2
Show member pathways
12.03 IFNG PLAT SERPINE1
3 11.79 NOS3 PLAT SERPINE1
4
Show member pathways
11.76 F10 F3 PLAT SERPINE1
5 11.67 CSF2 IFNG ITGA2B
6 11.61 IFNG PLAT SERPINE1
7 11.6 F10 F3 PLAT SERPINE1
8 11.54 IFNG NOS3 SERPINE1
9 11.49 F3 NOS3 SERPINE1
10 11.4 IFNG ITGA2B NOS3 PLAT
11 11.26 IFNG SELP
12 11.24 PLAT SELP
13 11.23 CSF2 ITGA2B
14
Show member pathways
11.09 CSF2 IFNG
15 10.99 CSF2 IFNG
16 10.89 IFNG SELP
17 10.57 PLAT SERPINE1

GO Terms for Carotid Artery Thrombosis

Cellular components related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CSF2 F10 F3 IFNG PLAT SERPINE1
2 extracellular space GO:0005615 9.43 CSF2 F3 IFNG PLAT SELP SERPINE1
3 platelet alpha granule membrane GO:0031092 9.16 ITGA2B SELP
4 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.61 F10 F3 PLAT
2 positive regulation of angiogenesis GO:0045766 9.54 F3 NOS3 SERPINE1
3 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.46 NOS3 SERPINE1
4 platelet degranulation GO:0002576 9.43 ITGA2B SELP SERPINE1
5 fibrinolysis GO:0042730 9.4 PLAT SERPINE1
6 positive regulation of leukocyte migration GO:0002687 9.32 ITGA2B SELP
7 response to fluid shear stress GO:0034405 9.16 CSF2 NOS3
8 positive regulation of interleukin-23 production GO:0032747 8.96 CSF2 IFNG
9 blood coagulation, extrinsic pathway GO:0007598 8.62 F10 F3

Molecular functions related to Carotid Artery Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F10 F3 PLAT

Sources for Carotid Artery Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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