MCID: CRT004
MIFTS: 45

Carotid Artery Thrombosis malady

Blood diseases category

Summaries for Carotid Artery Thrombosis

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32MalaCards
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MalaCards: Carotid Artery Thrombosis is related to nephrotic syndrome and diabetes mellitus. An important gene associated with Carotid Artery Thrombosis is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds p-amino benzamidine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and brain, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Carotid Artery Thrombosis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

carotid artery thrombosis 8 44 60


External Ids:

Disease Ontology8 DOID:3410
SNOMED-CT56 86003009, 195181000
MeSH34 D002341

Related Diseases for Carotid Artery Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.2SERPINC1
2diabetes mellitus30.2COG2, F10, NOS3, SERPINE1, SERPINC1
3myocardial infarction30.1COG2, F10, F3, P2RY12, NOS3, SERPINE1
4carotid stenosis10.3
5rubella10.1
6myelitis10.1
7cerebritis10.1
8pharyngitis10.1
9neuronitis10.1
10type 1 diabetes mellitus10.1
11carotid artery occlusion10.1
12familial hypercholesterolemia10.1
13horner's syndrome10.1
14aspergillosis10.1
15carotid artery disease10.1
16encephalitis10.1
17endophthalmitis10.1
18neuritis10.1
19optic neuritis10.1
20von willebrand's disease10.0F3
21herpes simplex10.0F10
22polycystic ovary syndrome10.0SERPINE1
23viral hepatitis10.0F10
24amyloidosis10.0F10
25hepatitis10.0F10
26purpura10.0SERPINC1
27astrocytoma10.0P2RY12
28cerebrovascular disease10.0COG2
29hepatocellular carcinoma10.0F10
30eclampsia10.0SERPINC1
31portal vein thrombosis10.0SERPINC1
32hypothyroidism10.0COG2
33sickle cell disease10.0NOS3
34retinal vein occlusion10.0SERPINC1
35portal hypertension10.0NOS3
36sagittal sinus thrombosis10.0SERPINC1
37uremia10.0NOS3
38schistosomiasis10.0IFNG
39malaria10.0IFNG
40multiple sclerosis10.0IFNG
41purpura fulminans10.0SERPINC1
42dysfibrinogenemia10.0SERPINC1
43meningococcemia10.0SERPINC1
44hepatitis b10.0IFNG
45prostate cancer10.0NOS3
46lupus erythematosus10.0SERPINC1, F3
47hepatitis c10.0IFNG
48factor x deficiency10.0F3, F10
49respiratory failure10.0SERPINC1, F3
50hemarthrosis10.0F3, F10

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to carotid artery thrombosis

Clinical Features for Carotid Artery Thrombosis

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Drugs & Therapeutics for Carotid Artery Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Carotid Artery Thrombosis

Drug clinical trials:

Search ClinicalTrials for Carotid Artery Thrombosis

Search NIH Clinical Center for Carotid Artery Thrombosis

Search CenterWatch for Carotid Artery Thrombosis

Genetic Tests for Carotid Artery Thrombosis

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Anatomical Context for Carotid Artery Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Carotid Artery Thrombosis:

32
Bone, Liver, Brain, Endothelial

Animal Models for Carotid Artery Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0GCNT2
2MP:001077110.0GCNT2
3MP:00053857.2IFNG, CSF2, F10, F3, NOS3, SERPINE1
4MP:00053976.8GCNT2, IFNG, CSF2, F3, P2RY12, NOS3
5MP:00053876.7GCNT2, IFNG, CSF2, F3, NOS3, SERPINE1
6MP:00107686.5COG2, IFNG, CSF2, F10, F3, NOS3
7MP:00053766.5SERPINC1, GCNT2, IFNG, CSF2, F10, F3

Publications for Carotid Artery Thrombosis

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50PubMed
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Articles related to Carotid Artery Thrombosis:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Symptomatic internal carotid artery thrombosis in acute carbon monoxide intoxication. (24388067)
2013
2
Carotid artery thrombosis treated with catheter intervention using proximal occlusion and flow reversal. (23645056)
2013
3
Preparation of thrombosis-targeted lipid microbubbles and determination of rabbit carotid artery thrombosis by microbubbles ultrasonogaphy. (23392725)
2013
4
Septic cavernous sinus thrombosis complicated by occlusion of the internal carotid artery and multiple embolic strokes after surgery of an anorectal abscess: a clinical chameleon. (22931741)
2012
5
A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits. (21158497)
2011
6
Internal carotid artery thrombosis after blunt trauma--salvage therapy with the penumbra thrombectomy system. (20349674)
2010
7
Polymorphisms in platelet glycoproteins Ia and IIIa are associated with arterial thrombosis and carotid atherosclerosis in type 2 diabetes. (20076847)
2010
8
Effect of a synthetic peptide corresponding to residues 313 to 320 of the alphaIIb subunit of the human platelet integrin alphaIIbbeta3 on carotid artery thrombosis in rabbits. (19244095)
2009
9
Septic cavernous sinus thrombosis complicated by narrowing of the internal carotid artery, subarachnoid abscess and multiple pulmonary septic emboli. (17380002)
2007
10
Invasive aspergillosis and thrombosis of carotid artery. (16599286)
2006
11
Acute carotid artery thrombosis: description of 12 surgically treated cases. (15714361)
2005
12
Prevention of carotid artery thrombosis after oral administration of the glycoprotein IIb/IIIa antagonist CRL42796. (12827029)
2003
13
Endothelial nitric oxide synthase pathophysiology after nonocclusive common carotid artery thrombosis in rats. (11973434)
2002
14
Spontaneous thrombosis of a giant intracavernous internal carotid artery aneurysm and ipsilateral internal carotid artery occlusion. (12450106)
2002
15
Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries. (12456493)
2002
16
Visual disturbance due to carotid artery thrombosis in a patient with familial hypercholesterolemia; response to surgical thrombotectomy. (11393415)
2001
17
Delayed bilateral internal carotid artery thrombosis following accidental strangulation. (10823110)
2000
18
S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. (11127876)
2000
19
The role of oculopneumoplethysmography in detecting acute carotid artery thrombosis in patients with neurologic deficits after carotid endarterectomy. (10875996)
2000
20
Internal carotid artery thrombosis and Horner's syndrome as complications of parapharyngeal abscess. (10388902)
1999
21
Ischemic stroke due to transient thrombosis of the internal carotid artery in a patient with combined antiphospholipid syndrome and factor V Leiden. (10569313)
1999
22
Prevention of carotid artery thrombosis by oral platelet GPIIb/IIIa antagonist in dogs. (9099204)
1997
23
Coexistence of cerebral venous sinus and internal carotid artery thrombosis associated with exogenous sex hormones. A case report. (8638876)
1996
24
In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. (8650721)
1996
25
Acute carotid artery thrombosis after neck irradiation. (7933034)
1994
26
Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis. (7955202)
1994
27
Internal carotid artery thrombosis following manual strangulation. (8429772)
1993
28
Serotonin release into plasma during common carotid artery thrombosis in rats. (1595108)
1992
29
Antithrombotic effects of the prostacyclin analogue naxaprostene after oral and intraduodenal application in rabbit carotid artery thrombosis. (1632291)
1992
30
Hemodynamic consequences of common carotid artery thrombosis and thrombogenically activated blood in rats. (1939389)
1991
31
Bilateral carotid artery thrombosis. (2802134)
1989
32
Internal carotid artery thrombosis: a complication of closed craniocervical trauma. (2695572)
1989
33
Maternal death from carotid artery thrombosis associated with the syndrome of hemolysis, elevated liver function, and low platelets. (2730743)
1989
34
Internal carotid artery thrombosis. (3830003)
1987
35
Bilateral internal carotid artery thrombosis after closed head injury. (726960)
1978
36
Disseminated aspergillosis. Aspergillus endophthalmitis, optic nerve infarction, and carotid artery thrombosis. (1147836)
1975
37
Carotid artery thrombosis, encephalitis, myelitis and optic neuritis associated with rubella virus infections. (1218369)
1975
38
Rhincerebral phycomycosis and internal carotid artery thrombosis. (1122191)
1975
39
Internal carotid artery thrombosis following head injury in a 17-month-old child. (4646430)
1972
40
Internal carotid artery thrombosis secondary to closed head injury. (5434376)
1970
41
Internal carotid artery thrombosis secondary to closed craniocervical trauma. (5635423)
1968
42
Juvenile bilateral carotid artery thrombosis. (4170404)
1966
43
Combined use of fibrinolysin and endarterectomy. Results in stenosis with recent carotid artery thrombosis. (13889682)
1961
44
Carotid artery thrombosis in persons fifteen years of age or younger. (13672788)
1959
45
Ophthalmodynamometry and carotid artery thrombosis. (13637162)
1959
46
Internal carotid artery thrombosis. (13520075)
1958
47
Pulseless disease and carotid-artery thrombosis; surgical considerations. (13477371)
1957
48
Collateral circulation of the external carotid artery and the internal carotid artery through the ophthalmic artery in cases of internal carotid artery thrombosis; report of five cases. (13273646)
1955
49
Arteriographic demonstration of collateral circulation through ophthalmic artery in internal carotid artery thrombosis; report of two cases. (13184347)
1954
50
Carotid artery thrombosis; report of eight cases due to trauma. (18864120)
1948

Genetic Variations for Carotid Artery Thrombosis

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Expression for genes affiliated with Carotid Artery Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for genes affiliated with Carotid Artery Thrombosis

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53Reactome, 49PharmGKB, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8F3, F10
2
Hide members
9.4SERPINC1, F3, F10
3
Hide members
9.4NOS3, P2RY12, F3
4
Hide members
9.1SERPINC1, SERPINE1, F3, F10
5
Hide members
9.1F10, F3, SERPINE1, SERPINC1
6
Hide members
9.1F10, F3, SERPINE1, SERPINC1
79.0CSF2, IFNG
8
Hide members
9.0IFNG, F3, SERPINE1
99.0CSF2, IFNG
108.9SERPINE1, NOS3, IFNG

Compounds for genes affiliated with Carotid Artery Thrombosis

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1p-amino benzamidine4410.5SERPINE1
2estrogen4410.1COG2
3endotoxin4410.0F3, SERPINE1
4n(g)-nitro-l-arginine methyl ester4410.0F3, NOS3
5dabigatran449.8F10, SERPINC1, F3
6efegatran449.8F10, F3, SERPINC1
7ecarin449.8F3, F10, SERPINC1
8nadroparin44 1110.8SERPINC1, F3, F10
9spectrozyme449.8F10, SERPINC1, F3
10danaparoid449.8SERPINC1, F3, F10
11organon449.8F3, SERPINC1, F10
12rivaroxaban44 1110.8SERPINC1, F10, F3
13tinzaparin44 1110.8SERPINC1, F3, F10
14celite449.8SERPINC1, F3
15ximelagatran44 1110.8F10, SERPINC1, F3
16tranexamic acid44 1110.8SERPINE1, F3, SERPINC1
17heparinoids449.8F3, SERPINC1, F10
18fondaparinux449.7F10, F3, SERPINC1
19ancrod449.7SERPINE1, SERPINC1, F10
20bivalirudin44 1110.7F10, F3, SERPINC1
21argatroban44 1110.7SERPINC1, F3, F10
22epsilon aminocaproic acid449.7F3, SERPINC1, SERPINE1
23protamine sulfate449.7F3, SERPINC1, F10
24Fondaparinux sodium119.7SERPINC1, F10
25fucoidan449.7SERPINC1, SERPINE1, F3
26heparin pentasaccharide449.6SERPINC1, F10
27anisodamine449.6SERPINE1, F3
28ppack449.5F10, F3, P2RY12, SERPINC1
29tirofiban44 1110.5P2RY12, F3, F10, SERPINC1
30hirudin449.5F10, F3, SERPINE1, SERPINC1
31abciximab44 1110.5P2RY12, F3, F10, SERPINC1
32protamine449.5SERPINC1, SERPINE1, F3, F10
33nomegestrol acetate449.4NOS3, COG2, SERPINC1
34aprotinin44 1110.4SERPINC1, SERPINE1, F3, F10
35ticlopidine44 1110.2F3, CSF2, P2RY12, SERPINC1
36citrate449.2F10, F3, SERPINC1, NOS3
37heparin44 28 11 2412.1COG2, P2RY12, CSF2, F10
38clopidogrel49 44 11 2412.0F10, SERPINC1, NOS3, F3, P2RY12
39heparan sulfate44 2410.0GCNT2, SERPINC1, SERPINE1, F10
40cyclophosphamide44 49 1111.0NOS3, CSF2, F3, SERPINE1
41homocysteine44 249.9SERPINE1, SERPINC1, NOS3, F3, COG2
42fibrinogen448.6F10, F3, P2RY12, SERPINE1, SERPINC1, COG2
4315-deoxy-delta-12,14-prostaglandin j2448.6CSF2, IFNG, SERPINE1, NOS3
44polysaccharide448.5SERPINC1, GCNT2, CSF2, F10, F3
45actinomycin d448.2NOS3, F3, IFNG, CSF2, SERPINE1
46simvastatin44 49 59 28 11 2413.1SERPINE1, NOS3, IFNG, F3, F10, COG2
47sb 20358044 599.0SERPINE1, NOS3, F3, F10, CSF2, IFNG
48vegf447.6SERPINC1, SERPINE1, IFNG, CSF2, F10, F3
49aspirin44 49 28 2410.6CSF2, NOS3, F3, F10, COG2, P2RY12
50retinoic acid44 248.5SERPINE1, NOS3, F3, CSF2, IFNG, GCNT2

GO Terms for genes affiliated with Carotid Artery Thrombosis

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16Gene Ontology
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Cellular components related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to external side of plasma membraneGO:0312339.5F3, F10
2extracellular spaceGO:0056158.0SERPINC1, SERPINE1, F3, CSF2, IFNG

Biological processes related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.8F10, F3
2negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7SERPINE1, NOS3
3positive regulation of interleukin-23 productionGO:0327479.1IFNG, CSF2
4positive regulation of angiogenesisGO:0457669.1F3, NOS3, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.6SERPINE1, CSF2, IFNG
6blood coagulationGO:0075968.4SERPINC1, SERPINE1, NOS3, P2RY12, F3, F10

Molecular functions related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4SERPINC1, SERPINE1, F3

Products for genes affiliated with Carotid Artery Thrombosis

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  • Antibodies
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Sources for Carotid Artery Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet