MCID: CRT004
MIFTS: 45

Carotid Artery Thrombosis malady

Blood diseases category

Summaries for Carotid Artery Thrombosis

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32MalaCards
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MalaCards: Carotid Artery Thrombosis is related to nephrotic syndrome and diabetes mellitus. An important gene associated with Carotid Artery Thrombosis is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds p-amino benzamidine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and liver, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Carotid Artery Thrombosis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

carotid artery thrombosis 8 44 60


External Ids:

Disease Ontology8 DOID:3410
SNOMED-CT56 86003009, 195181000
MeSH34 D002341

Related Diseases for Carotid Artery Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Carotid Artery Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.2SERPINC1
2diabetes mellitus30.2COG2, F10, NOS3, SERPINE1, SERPINC1
3myocardial infarction30.1COG2, F10, F3, P2RY12, NOS3, SERPINE1
4carotid stenosis10.3
5rubella10.1
6myelitis10.1
7cerebritis10.1
8pharyngitis10.1
9neuronitis10.1
10type 1 diabetes mellitus10.1
11carotid artery occlusion10.1
12familial hypercholesterolemia10.1
13horner's syndrome10.1
14aspergillosis10.1
15carotid artery disease10.1
16encephalitis10.1
17endophthalmitis10.1
18neuritis10.1
19optic neuritis10.1
20von willebrand's disease10.0F3
21herpes simplex10.0F10
22polycystic ovary syndrome10.0SERPINE1
23viral hepatitis10.0F10
24amyloidosis10.0F10
25hepatitis10.0F10
26purpura10.0SERPINC1
27astrocytoma10.0P2RY12
28cerebrovascular disease10.0COG2
29hepatocellular carcinoma10.0F10
30eclampsia10.0SERPINC1
31portal vein thrombosis10.0SERPINC1
32hypothyroidism10.0COG2
33sickle cell disease10.0NOS3
34retinal vein occlusion10.0SERPINC1
35portal hypertension10.0NOS3
36sagittal sinus thrombosis10.0SERPINC1
37uremia10.0NOS3
38schistosomiasis10.0IFNG
39malaria10.0IFNG
40multiple sclerosis10.0IFNG
41purpura fulminans10.0SERPINC1
42dysfibrinogenemia10.0SERPINC1
43meningococcemia10.0SERPINC1
44hepatitis b10.0IFNG
45prostate cancer10.0NOS3
46lupus erythematosus10.0SERPINC1, F3
47hepatitis c10.0IFNG
48factor x deficiency10.0F3, F10
49respiratory failure10.0SERPINC1, F3
50hemarthrosis10.0F3, F10

Graphical network of the top 20 diseases related to Carotid Artery Thrombosis:



Diseases related to carotid artery thrombosis

Clinical Features for Carotid Artery Thrombosis

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Drugs & Therapeutics for Carotid Artery Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Carotid Artery Thrombosis

Drug clinical trials:

Search ClinicalTrials for Carotid Artery Thrombosis

Search NIH Clinical Center for Carotid Artery Thrombosis

Search CenterWatch for Carotid Artery Thrombosis

Genetic Tests for Carotid Artery Thrombosis

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Anatomical Context for Carotid Artery Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Carotid Artery Thrombosis:

32
Bone, Brain, Liver, Endothelial

Animal Models for Carotid Artery Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Carotid Artery Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0GCNT2
2MP:001077110.0GCNT2
3MP:00053857.2IFNG, CSF2, F10, F3, NOS3, SERPINE1
4MP:00053976.8GCNT2, IFNG, CSF2, F3, P2RY12, NOS3
5MP:00053876.7GCNT2, IFNG, CSF2, F3, NOS3, SERPINE1
6MP:00107686.5COG2, IFNG, CSF2, F10, F3, NOS3
7MP:00053766.5SERPINC1, GCNT2, IFNG, CSF2, F10, F3

Publications for Carotid Artery Thrombosis

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Sources:
50PubMed
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Articles related to Carotid Artery Thrombosis:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Internal carotid artery thrombosis due to an unusual soft palate injury in a child. (24317280)
2013
2
Superficial temporal artery-middle cerebral artery anastomosis for internal carotid artery occlusion by subacute in-stent thrombosis after carotid artery stenting. (23346328)
2012
3
Rare case of carotid artery occlusion due to thrombosis of a giant cerebral aneurysm: the role of cerebral revascularization. (22311227)
2012
4
Carotidynia with carotid arterial thrombosis. (23247948)
2012
5
Acute stent occlusion due to heparin induced thrombocytopenia and thrombosis during carotid artery stenting. (22131443)
2012
6
Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. (21479193)
2011
7
Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. (20694780)
2010
8
Carotid artery thrombosis and delayed stroke associated with the use of a shoulder belt in a teenager. (19635289)
2009
9
Effects of propyl gallate on carotid artery thrombosis and coagulation/fibrinolysis system in rats. (18568328)
2008
10
Lemierre syndrome complicated by cavernous sinus thrombosis, the development of subdural empyemas, and internal carotid artery narrowing without cerebral infarction. Case report. (17233314)
2007
11
Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature. (16390393)
2005
12
A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury. (15039280)
2004
13
Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture. (12890856)
2003
14
Differential effects of sodium nitroprusside and hydralazine in a rat model of topical FeCl3-induced carotid artery thrombosis. (14644081)
2003
15
Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. (14675104)
2003
16
Endothelial nitric oxide synthase pathophysiology after nonocclusive common carotid artery thrombosis in rats. (11973434)
2002
17
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis. (10688985)
2000
18
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis. (10991981)
2000
19
Noncollagenous bone matrix proteins, calcification, and thrombosis in carotid artery atherosclerosis. (10446063)
1999
20
Adenovirus-mediated local expression of human tissue factor pathway inhibitor eliminates shear stress-induced recurrent thrombosis in the injured carotid artery of the rabbit. (10381897)
1999
21
Rhinosino-orbital mucormycosis causing cavernous sinus thrombosis and internal carotid artery occlusion: radiological findings in a patient with treatment failure. (10561981)
1999
22
Traumatic internal carotid artery thrombosis after impalement injury. (9419147)
1997
23
Chimeric 7E3 prevents carotid artery thrombosis in cynomolgus monkeys. (8202985)
1994
24
Computed tomographic diagnosis of radiation-induced internal carotid artery thrombosis. (8457126)
1993
25
Thromboxane antagonism in experimental canine carotid artery thrombosis. (8506554)
1993
26
Bilateral carotid artery thrombosis in a young man. (8464104)
1993
27
Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis. (1605806)
1992
28
Internal carotid artery thrombosis after blunt maxillofacial trauma. (1923436)
1991
29
Rhinocerebral mucormycosis and internal carotid artery thrombosis in a previously healthy patient. (2111071)
1990
30
Carotid artery thrombosis and myocardial infarction in nephrotic syndrome]. (2106297)
1990
31
Danazol and internal carotid artery thrombosis. (2759149)
1989
32
Prevention of experimental carotid artery thrombosis by magnetic vectoring of aspirin. (2887851)
1987
33
Internal carotid artery thrombosis following soft palate injuries: a case report and review of 16 cases. (6390042)
1984
34
Internal carotid artery thrombosis presenting as catatonic stupor - case report. (21847298)
1983
35
Carotid artery thrombosis after elective mandibular and maxillary osteotomies. (7271163)
1981
36
Internal carotid artery thrombosis associated with a fracture. (277641)
1978
37
Bilateral internal carotid artery thrombosis. Prognosis and risk factors. (1146502)
1975
38
Internal carotid artery occlusion in cavernous sinus thrombosis. (5538597)
1971
39
Traumatic internal carotid artery thrombosis in a child. (5434377)
1970
40
The collateral circulation via the ophthalmic artery in internal carotid artery thrombosis. (5803592)
1969
41
A clinical and radiological analysis of 77 patients with internal carotid artery thrombosis. (5583230)
1967
42
Bilateral carotid artery thrombosis. (13699382)
1961
43
Evaluation of ophthalmodynamometric and angiographic findings in patients with internal carotid artery thrombosis. (13812943)
1960
44
The problem of internal carotid artery thrombosis. (13573002)
1958
45
Complications in the surgery of internal carotid artery thrombosis. (13564270)
1958
46
Bilateral internal carotid artery thrombosis; a report of two cases. (13250164)
1955
47
The relationship of some forms of cerebral atrophy and thrombosis of the internal carotid artery. (13238325)
1954
48
Stroke resulting from internal carotid artery thrombosis in the neck. (13011042)
1953
49
Traumatic internal carotid artery thrombosis secondary to nonpenetrating injuries to the neck; a problem in the differential diagnosis of craniocerebral trauma. (12981571)
1952
50
Thrombosis of left internal carotid artery; thromboangiitis obliterans. (14774737)
1950

Genetic Variations for Carotid Artery Thrombosis

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Expression for genes affiliated with Carotid Artery Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Artery Thrombosis

Search GEO for disease gene expression data for Carotid Artery Thrombosis.

Pathways for genes affiliated with Carotid Artery Thrombosis

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53Reactome, 49PharmGKB, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8F3, F10
2
Hide members
9.4SERPINC1, F3, F10
3
Hide members
9.4NOS3, P2RY12, F3
4
Hide members
9.1SERPINC1, SERPINE1, F3, F10
5
Hide members
9.1F10, F3, SERPINE1, SERPINC1
6
Hide members
9.1F10, F3, SERPINE1, SERPINC1
79.0CSF2, IFNG
8
Hide members
9.0IFNG, F3, SERPINE1
99.0CSF2, IFNG
108.9SERPINE1, NOS3, IFNG

Compounds for genes affiliated with Carotid Artery Thrombosis

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1p-amino benzamidine4410.5SERPINE1
2estrogen4410.1COG2
3endotoxin4410.0F3, SERPINE1
4n(g)-nitro-l-arginine methyl ester4410.0F3, NOS3
5dabigatran449.8F10, SERPINC1, F3
6efegatran449.8F10, F3, SERPINC1
7ecarin449.8F3, F10, SERPINC1
8nadroparin44 1110.8SERPINC1, F3, F10
9spectrozyme449.8F10, SERPINC1, F3
10danaparoid449.8SERPINC1, F3, F10
11organon449.8F3, SERPINC1, F10
12rivaroxaban44 1110.8SERPINC1, F10, F3
13tinzaparin44 1110.8SERPINC1, F3, F10
14celite449.8SERPINC1, F3
15ximelagatran44 1110.8F10, SERPINC1, F3
16tranexamic acid44 1110.8SERPINE1, F3, SERPINC1
17heparinoids449.8F3, SERPINC1, F10
18fondaparinux449.7F10, F3, SERPINC1
19ancrod449.7SERPINE1, SERPINC1, F10
20bivalirudin44 1110.7F10, F3, SERPINC1
21argatroban44 1110.7SERPINC1, F3, F10
22epsilon aminocaproic acid449.7F3, SERPINC1, SERPINE1
23protamine sulfate449.7F3, SERPINC1, F10
24Fondaparinux sodium119.7SERPINC1, F10
25fucoidan449.7SERPINC1, SERPINE1, F3
26heparin pentasaccharide449.6SERPINC1, F10
27anisodamine449.6SERPINE1, F3
28ppack449.5F10, F3, P2RY12, SERPINC1
29tirofiban44 1110.5P2RY12, F3, F10, SERPINC1
30hirudin449.5F10, F3, SERPINE1, SERPINC1
31abciximab44 1110.5P2RY12, F3, F10, SERPINC1
32protamine449.5SERPINC1, SERPINE1, F3, F10
33nomegestrol acetate449.4NOS3, COG2, SERPINC1
34aprotinin44 1110.4SERPINC1, SERPINE1, F3, F10
35ticlopidine44 1110.2F3, CSF2, P2RY12, SERPINC1
36citrate449.2F10, F3, SERPINC1, NOS3
37heparin44 28 11 2412.1COG2, P2RY12, CSF2, F10
38clopidogrel49 44 11 2412.0F10, SERPINC1, NOS3, F3, P2RY12
39heparan sulfate44 2410.0GCNT2, SERPINC1, SERPINE1, F10
40cyclophosphamide44 49 1111.0NOS3, CSF2, F3, SERPINE1
41homocysteine44 249.9SERPINE1, SERPINC1, NOS3, F3, COG2
42fibrinogen448.6F10, F3, P2RY12, SERPINE1, SERPINC1, COG2
4315-deoxy-delta-12,14-prostaglandin j2448.6CSF2, IFNG, SERPINE1, NOS3
44polysaccharide448.5SERPINC1, GCNT2, CSF2, F10, F3
45actinomycin d448.2NOS3, F3, IFNG, CSF2, SERPINE1
46simvastatin44 49 59 28 11 2413.1SERPINE1, NOS3, IFNG, F3, F10, COG2
47sb 20358044 599.0SERPINE1, NOS3, F3, F10, CSF2, IFNG
48vegf447.6SERPINC1, SERPINE1, IFNG, CSF2, F10, F3
49aspirin44 49 28 2410.6CSF2, NOS3, F3, F10, COG2, P2RY12
50retinoic acid44 248.5SERPINE1, NOS3, F3, CSF2, IFNG, GCNT2

GO Terms for genes affiliated with Carotid Artery Thrombosis

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16Gene Ontology
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Cellular components related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to external side of plasma membraneGO:0312339.5F3, F10
2extracellular spaceGO:0056158.0SERPINC1, SERPINE1, F3, CSF2, IFNG

Biological processes related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.8F10, F3
2negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7SERPINE1, NOS3
3positive regulation of interleukin-23 productionGO:0327479.1IFNG, CSF2
4positive regulation of angiogenesisGO:0457669.1F3, NOS3, SERPINE1
5cellular response to lipopolysaccharideGO:0712228.6SERPINE1, CSF2, IFNG
6blood coagulationGO:0075968.4SERPINC1, SERPINE1, NOS3, P2RY12, F3, F10

Molecular functions related to Carotid Artery Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4SERPINC1, SERPINE1, F3

Products for genes affiliated with Carotid Artery Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carotid Artery Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet