CBT
MCID: CRT025
MIFTS: 25

Carotid Body Tumor (CBT) malady

Cancer diseases category

Summaries for Carotid Body Tumor

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 A paraganglioma is rare neuroendocrine neoplasm that may develop at various body sites (including the... more...

MalaCards: Carotid Body Tumor, also known as carotid body paraganglioma, is related to paraganglioma and glomus tumor. An important gene associated with Carotid Body Tumor is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are IL-6 Signaling Pathway and ErbB signaling pathway. The compounds mibg and catecholamine have been mentioned in the context of this disorder.

Aliases & Classifications for Carotid Body Tumor

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Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

carotid body tumor 42 44
carotid body paraganglioma 42 60
carotid body tumors 42
cbt 42


Related Diseases for Carotid Body Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Carotid Body Tumor:



Diseases related to carotid body tumor

Clinical Features for Carotid Body Tumor

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Drugs & Therapeutics for Carotid Body Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Carotid Body Tumor

Drug clinical trials:

Search ClinicalTrials for Carotid Body Tumor

Search NIH Clinical Center for Carotid Body Tumor

Search CenterWatch for Carotid Body Tumor

Genetic Tests for Carotid Body Tumor

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Anatomical Context for Carotid Body Tumor

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Animal Models for Carotid Body Tumor or affiliated genes

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Publications for Carotid Body Tumor

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Genetic Variations for Carotid Body Tumor

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Expression for genes affiliated with Carotid Body Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Body Tumor

Search GEO for disease gene expression data for Carotid Body Tumor.

Pathways for genes affiliated with Carotid Body Tumor

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Sources:
37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Carotid Body Tumor

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Carotid Body Tumor according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1mibg449.5SDHB, SDHD
2catecholamine449.4SDHB, SDHD
3UBIQUINONE-1119.1SDHC, SDHB, SDHD
42-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol119.1SDHC, SDHB, SDHD
5fumarate44 1110.1SDHD, SDHB, SDHC
6succinic acid28 11 2411.1SDHD, SDHB, SDHC
7iron-sulfur449.1SDHD, SDHB, SDHC
8ubiquinone449.1SDHC, SDHB, SDHD
9succinate449.0SDHD, SDHB, SDHC
10ag 1478448.8ERBB3, JUN
11iron44 249.8SDHC, SDHB, SDHD
12oxygen44 249.4JUN, SDHD, SDHB, SDHC
13vegf448.1SDHC, SDHB, ERBB3, JUN

GO Terms for genes affiliated with Carotid Body Tumor

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Sources:
16Gene Ontology
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Cellular components related to Carotid Body Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057438.9SDHC, SDHB, SDHD
2mitochondrial respiratory chain complex IIGO:0057498.6SDHC, SDHB, SDHD

Biological processes related to Carotid Body Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.1ERBB3, JUN
2aerobic respirationGO:0090609.0SDHC, SDHB
3tricarboxylic acid cycleGO:0060998.9SDHC, SDHB, SDHD
4respiratory electron transport chainGO:0229048.9SDHC, SDHB, SDHD
5cellular metabolic processGO:0442378.8SDHD, SDHB, SDHC

Molecular functions related to Carotid Body Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.5SDHC, SDHD
2ubiquinone bindingGO:0480399.3SDHB, SDHD
3electron carrier activityGO:0090558.6SDHC, SDHB, SDHD

Products for genes affiliated with Carotid Body Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carotid Body Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet