CBT
MCID: CRT025
MIFTS: 41

Carotid Body Tumor (CBT) malady

Rare diseases, Cancer diseases categories
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Summaries for Carotid Body Tumor

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Wikipedia:65 A paraganglioma is rare neuroendocrine neoplasm that may develop at various body sites (including the... more...

MalaCards based summary: Carotid Body Tumor, also known as carotid body paraganglioma, is related to paraganglioma and pheochromocytoma. An important gene associated with Carotid Body Tumor is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are IL-6 Signaling Pathway and ErbB signaling pathway. The compounds mibg and heme have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and heart.

Aliases & Classifications for Carotid Body Tumor

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
See all sources

Carotid Body Tumor, Aliases & Descriptions:

Name: Carotid Body Tumor 42 44
Carotid Body Paraganglioma 42 62
 
Carotid Body Tumors 42
Cbt 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Carotid Body Tumor

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Graphical network of the top 20 diseases related to Carotid Body Tumor:



Diseases related to carotid body tumor

Symptoms for Carotid Body Tumor

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Drugs & Therapeutics for Carotid Body Tumor

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Drug clinical trials:

Search ClinicalTrials for Carotid Body Tumor

Search NIH Clinical Center for Carotid Body Tumor

Genetic Tests for Carotid Body Tumor

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Anatomical Context for Carotid Body Tumor

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MalaCards organs/tissues related to Carotid Body Tumor:

32
Thyroid, Lymph node, Heart, Bone, Brain, Liver, Salivary gland, Trachea

Animal Models for Carotid Body Tumor or affiliated genes

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Publications for Carotid Body Tumor

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Articles related to Carotid Body Tumor:

(show top 50)    (show all 228)
idTitleAuthorsYear
1
Novel germline SDHD mutation in a patient with recurrent familial carotid body tumor and concomitant pheochromocytoma. (24599702)
2014
2
Implications of carotid sinus hypersensitivity following preoperative embolization of a carotid body tumor. An indication for prophylactic intraoperative cardiac pacing. (24651937)
2014
3
Dealing with a challenging carotid body tumor. (24836769)
2014
4
Results from craniocaudal carotid body tumor resection: should it be the standard surgical approach? (24091094)
2013
5
Anesthetic management of schwannoma mimicking carotid body tumor. (23754924)
2012
6
Carotid body tumor and amyloidosis: an uncommon association. (20228525)
2010
7
A rare case of familial carotid body tumor in a patient with bilateral fibromuscular dysplasia. (20620007)
2010
8
Carotid body tumor. (19155078)
2010
9
Baroreflex failure syndrome: a rare complication of bilateral carotid body tumor excision. (20935434)
2010
10
Direct percutaneous embolization of a carotid body tumor with Onyx. (18847339)
2009
11
Elective shunt use for easy resection of a carotid body tumor. (18258162)
2008
12
Nonresectable carotid body tumor: hybrid surgical procedure to achieve complete and safe resection. (18302274)
2008
13
Role of the genetic study in the management of carotid body tumor in paraganglioma syndrome. (18692411)
2008
14
Atypical carotid body tumor. (18427663)
2008
15
Multiple osseous metastases of a carotid body tumor in a dog. (17409648)
2007
16
Paraganglioma of the vagus nerve mimicking as a carotid body tumor. (17606133)
2007
17
"Malignant" baroreflex failure after surgical resection of carotid body tumor. (17395286)
2007
18
Direct percutaneous embolization of a carotid body tumor with n-butyl cyanoacrylate: an alternative method to endovascular embolization. (15587423)
2004
19
Vascular leiomyoma of the carotid sheath simulating a carotid body tumor. (9550446)
1998
20
Fine-needle aspiration diagnosis of carotid body tumor: report of a case and review of experience with cytologic features in four cases. (9258623)
1997
21
Syncope caused by carotid body tumor. (9046120)
1996
22
Oncogene expression in carotid body tumors. (8640709)
1996
23
Functional carotid body tumor: report of a case and a review of the literature. (8571210)
1996
24
Carotid body tumor: a case history. (7970820)
1994
25
Carotid body tumor associated with differentiated thyroid carcinoma. (11894786)
1994
26
Carotid body tumor: appearance on color-flow Doppler sonography. (1950148)
1991
27
Pulsed Doppler-ultrasonic diagnosis of carotid body tumor. (2691940)
1989
28
Carotid body tumor: atypical angiogram of a functional tumor. (3334680)
1987
29
Carotid body tumor: an incidental finding in older ranch mink. (3962082)
1986
30
Digital subtraction angiography for preoperative diagnosis of carotid body tumor. Case report. (3899988)
1985
31
Carotid body tumor seen on computed tomography. (6872562)
1983
32
Computed tomography of a carotid body tumor. (512117)
1979
33
Multiple chemodectomas: concurrent left carotid body tumor and right glomus jugulare tumor. (4338435)
1972
34
Aspiration biopsy of tumors of the neck. II. Cytologic findings in 13 cases of carotid body tumor. (5278739)
1971
35
Angiofibroma clinically indistinguishable from carotid body tumor. A possible embryologic relationship. (4315662)
1970
36
Excision of malignant carotid body tumor: resection of carotid bifurcation with autogenous vein graft. (5347886)
1969
37
The carotid body tumor. (5649728)
1968
38
Surgical management of carotid body tumor. (6053959)
1967
39
CAROTID BODY TUMOR. REPORT OF A CASE. (14113290)
1964
40
CAROTID BODY TUMOR. (14215124)
1964
41
A MALIGNANT CAROTID BODY TUMOR IN AN AFRICAN. (14068964)
1963
42
Carotid body tumor in tissue culture. (13881631)
1962
43
Carotid body tumor, its recognition, resection, and replacement by arterial graft. (13890290)
1962
44
Carotid body tumor with vascular insufficiency demonstrated by arteriography. (14447451)
1961
45
Further observations on the structure of a carotid body tumor. (13844973)
1960
46
Carotid body tumor in the dog. (13716433)
1960
47
The carotid body tumor in dogs. (13549300)
1958
48
Carotid body tumor confused with carotid aneurysm. (13205297)
1954
49
Bilateral carotid body tumor. (18122207)
1949
50
Carotid body tumor in association with carotid sinus syndrome; report of two cases. (20256789)
1947

Variations for Carotid Body Tumor

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Expression for genes affiliated with Carotid Body Tumor

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Expression patterns in normal tissues for genes affiliated with Carotid Body Tumor

Search GEO for disease gene expression data for Carotid Body Tumor.

Pathways for genes affiliated with Carotid Body Tumor

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Pathways related to Carotid Body Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1JUN, ERBB3
2
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.1ERBB3, JUN
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.1ERBB3, JUN
4
Show member pathways
9.1ERBB3, JUN
5
Show member pathways
9.1ERBB3, JUN
69.1ERBB3, JUN
7
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
8.9SDHC, SDHD, SDHB
8
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
8.9SDHB, SDHD, SDHC
9
Show member pathways
Alzheimers Disease37
8.9SDHB, SDHD, SDHC
10
Show member pathways
8.4JUN, SDHC, SDHD, SDHB

Compounds for genes affiliated with Carotid Body Tumor

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Carotid Body Tumor according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1mibg449.5SDHB, SDHD
2heme28 24 1111.5SDHC, SDHD
3catecholamine449.4SDHB, SDHD
4Fumaric acid249.2SDHC, SDHD, SDHB
5fumarate44 1110.2SDHC, SDHD, SDHB
6ag 1478449.2ERBB3, JUN
7succinic acid28 24 1111.2SDHB, SDHD, SDHC
8iron-sulfur449.2SDHB, SDHD, SDHC
9ubiquinone449.2SDHB, SDHD, SDHC
10Sulfide249.2SDHC, SDHD, SDHB
11QH2249.2SDHC, SDHD, SDHB
12Ubiquinone Q2249.1SDHB, SDHD, SDHC
13Ubiquinone Q1249.1SDHC, SDHD, SDHB
14succinate449.1SDHB, SDHD, SDHC
15FAD249.1SDHB, SDHD, SDHC
16egcg449.0ERBB3, JUN
17iron44 2410.0SDHC, SDHD, SDHB
18quercetin44 61 24 1111.8ERBB3, JUN
19oxygen44 249.5JUN, SDHC, SDHD, SDHB
20vegf448.2ERBB3, JUN, SDHC, SDHB

GO Terms for genes affiliated with Carotid Body Tumor

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Cellular components related to Carotid Body Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057398.9SDHC, SDHD, SDHB
2mitochondrial respiratory chain complex IIGO:0057498.8SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:0057438.6SDHC, SDHD, SDHB

Biological processes related to Carotid Body Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aerobic respirationGO:0090609.2SDHC, SDHB
2Fc-epsilon receptor signaling pathwayGO:0380959.1ERBB3, JUN
3tricarboxylic acid cycleGO:0060999.0SDHC, SDHD, SDHB
4respiratory electron transport chainGO:0229048.9SDHC, SDHD, SDHB
5cellular metabolic processGO:0442378.9SDHB, SDHD, SDHC
6negative regulation of neuron apoptotic processGO:0435248.8ERBB3, JUN

Molecular functions related to Carotid Body Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase activityGO:0001049.5SDHC, SDHD
2heme bindingGO:0200379.5SDHC, SDHD
3ubiquinone bindingGO:0480399.1SDHD, SDHB
4electron carrier activityGO:0090558.8SDHC, SDHD, SDHB

Products for genes affiliated with Carotid Body Tumor

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  • Antibodies
  • Proteins
  • Lysates

Sources for Carotid Body Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet