MCID: CRT013
MIFTS: 49

Carotid Stenosis malady

Cardiovascular diseases category
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Summaries for Carotid Stenosis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Carotid stenosis is a narrowing or constriction of the inner surface (lumen) of the carotid artery,... more...

MalaCards: Carotid Stenosis, also known as carotid stenosis, susceptibility to, is related to ischemia and hepatitis. An important gene associated with Carotid Stenosis is HABP2 (hyaluronan binding protein 2), and among its related pathways are IL-3 Signaling Pathway and amb2 Integrin signaling. The compounds sele and lxa4 have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Carotid Stenosis

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8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

carotid stenosis 8 47 10 45 62
carotid stenosis, susceptibility to 9
stenosis, carotid artery 8
carotid artery stenosis 8


External Ids:

Disease Ontology8 DOID:13001
SNOMED-CT58 64586002, 195181000
MeSH35 D016893

Related Diseases for Carotid Stenosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.6FABP2, PON1, SELP
2hepatitis30.5PON1, SELP
3abdominal aortic aneurysm30.5MMP1, MMP9
4vascular disease30.4MMP9, PON1, SELP
5coronary artery disease30.2SELP, PON1
6thromboembolism30.1HABP2, SELP
7hyperhomocysteinemia30.1PON1, SELP
8proliferative diabetic retinopathy30.1SELP, MMP9
9glaucoma30.0PON1, MMP1
10cerebrovascular disease30.0PON1, FABP2, SELP
11breast cancer30.0MMP9, HABP2, MMP1
12atherosclerosis29.8PON1, HABP2, SELP, FABP2, MMP1, MMP9
13cerebritis10.8
14cervicitis10.5
15intracranial aneurysm10.4
16aneurysm10.4
17artery disease10.3
18aortic aneurysm10.3
19peripheral vascular disease10.3
20retinitis10.3
21carotid artery disease10.2
22cholesterol embolism10.2
23hypertension10.2
24sleep apnea10.2
25autonomic dysfunction10.2
26blindness10.2
27pituitary apoplexy10.2
28oral squamous cell carcinoma10.2
29aortitis10.2
30tetralogy of fallot10.2
31tracheal stenosis10.2
32moyamoya disease10.2
33subclavian steal syndrome10.2
34brain stem infarction10.2
35hepatic encephalopathy10.2
36kidney disease10.2
37mediastinitis10.2
38williams syndrome10.2
39sinusitis10.2
40arteriosclerosis10.1PON1
41synovitis10.1MMP1
42coronary stenosis10.1PON1, SELP
43antiphospholipid syndrome10.1PON1, SELP
44familial combined hyperlipidemia10.0FABP2, PON1
45familial hyperlipidemia10.0PON1, SELP
46glucose intolerance10.0FABP2, PON1
47hypertriglyceridemia10.0PON1, FABP2
48conjunctivochalasis10.0MMP1, MMP9
49middle ear cholesteatoma10.0MMP1, MMP9
50pulmonary emphysema10.0MMP1, MMP9

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to carotid stenosis

Symptoms for Carotid Stenosis

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Drugs & Therapeutics for Carotid Stenosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Carotid Stenosis

Search NIH Clinical Center for Carotid Stenosis

Genetic Tests for Carotid Stenosis

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Anatomical Context for Carotid Stenosis

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33MalaCards
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MalaCards organs/tissues related to Carotid Stenosis:

33
Brain, Heart, Bone, Smooth muscle, Breast, T cells, Endothelial

Animal Models for Carotid Stenosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Carotid Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1IL12A, FABP2, MMP1, MMP9, PON1, SELP

Publications for Carotid Stenosis

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Sources:
52PubMed
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Articles related to Carotid Stenosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Endovascular advances for extracranial carotid stenosis. (24402498)
2014
2
Safety and effectiveness of emergency carotid artery stenting for a high-grade carotid stenosis with intraluminal thrombus under proximal flow control in hyperacute and acute stroke. (22170821)
2013
3
Treatment of symptomatic carotid stenosis: carotid stent placement versus endarterectomy. (23873312)
2013
4
The analysis of the connection between plaque morphology of asymptomatic carotid stenosis and ischemic brain lesions. (24397192)
2013
5
Reversal of ophthalmic artery flow and stroke outcomes in asian patients with acute ischemic stroke and unilateral severe cervical carotid stenosis. (24312492)
2013
6
Quantitative flow measurement by digital subtraction angiography in cerebral carotid stenosis using optical flow method. (23694912)
2013
7
A randomized trial of decision-making in asymptomatic carotid stenosis. (22218277)
2012
8
Secondary stroke prevention: patent foramen ovale, aortic plaque, and carotid stenosis. (22422912)
2012
9
Identifying high-risk asymptomatic carotid stenosis. (23480656)
2012
10
Carotid stenosis treatments compared. Both surgical and nonsurgical options can prevent stroke. (23437463)
2012
11
Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. (22935402)
2012
12
Circulating lipoprotein-associated phospholipase A2 in high-grade carotid stenosis: a new biomarker for predicting unstable plaque. (22075154)
2012
13
Controversies in neurology: asymptomatic carotid stenosis--intervention or just stick to medical therapy. The argument for carotid endarterectomy. (21298296)
2011
14
Update on surgical management for asymptomatic carotid stenosis. (20922504)
2011
15
Asymptomatic carotid stenosis: screening and management. (21667597)
2011
16
Treatment strategies for carotid stenosis in patients at increased risk for surgery. (21722783)
2011
17
Short-term outcome after stenting versus endarterectomy for symptomatic carotid stenosis: a preplanned meta-analysis of individual patient data. (20832852)
2010
18
Inraoperative and Histological Visualization of Disrupted Vulnerable Plaques following Diagnostic Angiography of Moderate Carotid Stenosis. (20700419)
2010
19
Extracranial carotid stenosis and peripheral arterial disease in Thai patients with coronary artery disease. (20483809)
2010
20
Reproducibility of semi-automated measurement of carotid stenosis on CTA. (20724259)
2010
21
Stroke: Carotid stenosis--surgery or stenting to prevent stroke? (21131910)
2010
22
How should physicians practically approach symptomatic and asymptomatic carotid stenosis? (20726212)
2010
23
Cardiac surgery, carotid stenosis, and stroke prevention. (20469611)
2010
24
Central sleep apnea indicates autonomic dysfunction in asymptomatic carotid stenosis: a potential marker of cerebrovascular and cardiovascular risk. (20337190)
2010
25
Carotid wall thickness and stroke risk in patients with asymptomatic internal carotid stenosis. (20079904)
2010
26
Two cases of branch retinal arterial occlusion after carotid artery stenting in the carotid stenosis. (19337482)
2009
27
Prevalence of carotid stenosis in a high-risk Caribbean population. (19246696)
2009
28
Strokes after cardiac surgery and relationship to carotid stenosis. (19752298)
2009
29
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis. (19416961)
2009
30
High risk of early neurological recurrence in symptomatic carotid stenosis. (19498196)
2009
31
High cardiovascular event rates in patients with asymptomatic carotid stenosis: the REACH Registry. (19473362)
2009
32
Temporal trends in the risks of stroke and death due to endarterectomy for symptomatic carotid stenosis: an updated systematic review. (19297217)
2009
33
Does metabolic syndrome predict silent carotid stenosis in coronary patients? (18283528)
2008
34
Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. (19012726)
2008
35
Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial. (18774745)
2008
36
Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting. (18486427)
2008
37
How asymptomatic is asymptomatic carotid stenosis? (17581914)
2007
38
Current status of carotid endarterectomy and stenting for symptomatic carotid stenosis. (17971647)
2007
39
Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from the ACSRS study. Nicolaides et al.: EJVES 2005; 30: 275-284. (16359888)
2006
40
Accuracy of angiography and Doppler ultrasonography in the detection of carotid stenosis: a histopathological study of 123 cases. (16523222)
2006
41
Accurate, practical and cost-effective assessment of carotid stenosis in the UK. (16904049)
2006
42
Atherosclerotic carotid stenosis and occlusion. (17290125)
2006
43
Recurrent carotid stenosis after angioplasty and stenting. (15874940)
2005
44
Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Results from the helsinki carotid endarterectomy study. (15775709)
2005
45
Commentary. Carotid angioplasty and stenting versus carotid endarterectomy for treatment of asymptomatic carotid stenosis: a randomized trial in a community hospital. (15952703)
2005
46
Carotid stenosis measurement on colour Doppler ultrasound: agreement of ECST, NASCET and CCA methods applied to ultrasound with intra-arterial angiographic stenosis measurement. (15964165)
2005
47
Carotid endarterectomy: update on the gold standard treatment for carotid stenosis. (16217946)
2005
48
Adhesion molecule expression in symptomatic and asymptomatic carotid stenosis. (12821729)
2003
49
An angiotensin-converting enzyme gene polymorphism suggests a genetic distinction between ischaemic stroke and carotid stenosis. (10354208)
1999
50
Cerebral ischemia in a patient with protein S deficiency and carotid stenosis. (8056555)
1994

Variations for Carotid Stenosis

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Expression for genes affiliated with Carotid Stenosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for genes affiliated with Carotid Stenosis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 12EMD Millipore, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Carotid Stenosis

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Sources:
45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Carotid Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1sele4510.0PON1, SELP
2lxa4459.9MMP1, SELP
3clopidogrel45 51 24 1112.8PON1, SELP
4cgs-27023a459.8MMP1, MMP9
5prinomastat459.8MMP9, MMP1
6ilomastat459.8MMP1, MMP9
7cilomilast459.7MMP9, MMP1
88-isoprostane459.7PON1, MMP9
9candesartan45 51 29 1112.7MMP1, SELP
10latanoprost45 1110.7MMP1, MMP9
11(4-aminophenyl)mercuric acetate459.7MMP9, MMP1
12quinacrine45 1110.7MMP1, SELP
13gm 6001619.7MMP1, MMP9
14gi 254023x619.7MMP9, MMP1
15uk 383367619.7MMP1, MMP9
16geranylgeranyl pyrophosphate459.7MMP9, MMP1
17hydroxamate459.6MMP9, MMP1
18marimastat45 61 1111.6MMP1, MMP9
19zoledronic acid459.6MMP1, MMP9
201,10-phenanthroline45 310.5MMP9, MMP1
21ns 39845 6110.5MMP9, MMP1
22simvastatin45 51 61 29 24 1114.5PON1, SELP, MMP9
23batimastat45 61 1111.4MMP9, MMP1
24pravastatin45 51 29 24 1113.4MMP1, SELP, PON1
25dextran sulfate459.4HABP2, SELP
26aspirin45 51 29 2412.4SELP, MMP1, PON1
27hyaluronic acid45 2410.4HABP2, MMP9, MMP1
28aprotinin45 1110.4MMP9, SELP, MMP1
29hydroxyproline45 24 1111.3MMP9, MMP1
30formaldehyde45 2410.3MMP9, SELP, MMP1
31alpha tocopherol459.3MMP1, MMP9, PON1
32rantes459.3MMP9, SELP, MMP1
33rosiglitazone29 45 51 24 1113.3PON1, MMP1, MMP9
34epinephrine45 24 1111.3MMP1, MMP9, SELP
35n acetylcysteine459.3SELP, MMP9, MMP1
36norepinephrine45 24 1111.2MMP1, MMP9, SELP
37fibrinogen459.2SELP, PON1, MMP9, HABP2
38genistein45 29 61 3 24 1114.1SELP, MMP1, MMP9
39mycophenolate mofetil45 51 1111.1MMP1, SELP, IL12A
40fenofibrate45 51 1111.0PON1, FABP2, SELP, MMP9
41cyclosporin a45 29 6111.0SELP, MMP1, MMP9
42pge2458.9MMP9, MMP1, SELP
43fluvastatin45 51 29 1111.9MMP9, PON1, MMP1, SELP
44atorvastatin45 51 29 24 1112.9PON1, MMP1, SELP, MMP9
45lactate458.8MMP9, SELP, MMP1
46vitamin a45 24 1110.8FABP2, MMP1, PON1, MMP9
47estrogen458.8SELP, PON1, MMP1, MMP9
48retinoic acid45 249.7SELP, MMP9, MMP1, FABP2
49creatinine458.4PON1, MMP9, MMP1, FABP2, SELP
50cysteine458.4MMP1, MMP9, PON1, SELP, FABP2

GO Terms for genes affiliated with Carotid Stenosis

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16Gene Ontology
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Cellular components related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5MMP1, MMP9, PON1, HABP2
2extracellular spaceGO:0056157.6IL12A, MMP9, PON1, SELP, HABP2

Biological processes related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2IL12A, SELP
2collagen catabolic processGO:0305749.2MMP1, MMP9
3extracellular matrix disassemblyGO:0226179.0MMP1, MMP9
4leukocyte migrationGO:0509008.9MMP1, MMP9, SELP

Molecular functions related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.3MMP1, MMP9

Products for genes affiliated with Carotid Stenosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carotid Stenosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet