MCID: CRT013
MIFTS: 52

Carotid Stenosis

Categories: Cardiovascular diseases

Aliases & Classifications for Carotid Stenosis

MalaCards integrated aliases for Carotid Stenosis:

Name: Carotid Stenosis 12 51 41 14 69
Carotid Stenosis, Susceptibility to 13
Stenosis, Carotid Artery 12
Carotid Artery Stenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13001
MeSH 41 D016893
NCIt 46 C95804
SNOMED-CT 64 195181000 64586002
UMLS 69 C0007282

Summaries for Carotid Stenosis

MalaCards based summary : Carotid Stenosis, also known as carotid stenosis, susceptibility to, is related to amaurosis fugax and peripheral vascular disease. An important gene associated with Carotid Stenosis is HABP2 (Hyaluronan Binding Protein 2), and among its related pathways/superpathways are Kaposi's sarcoma-associated herpesvirus infection and Toll-like receptor signaling pathway. The drugs Clopidogrel and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 72 Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually... more...

Related Diseases for Carotid Stenosis

Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 amaurosis fugax 30.3 MMP9 MTHFR
2 peripheral vascular disease 30.0 ACE CRP SELP
3 aortic valve disease 2 29.9 ACE CRP SPP1 TNFRSF11B
4 intermittent claudication 29.7 ACE CRP SELP
5 coronary artery anomaly 29.5 ACE APOE CRP MTHFR SELP
6 carotid artery disease 29.5 ACE APOE CRP MMP1 MMP9
7 takayasu arteritis 29.5 CRP MMP9 TNF
8 peripheral artery disease 29.5 ACE CRP SELP TNFRSF11B
9 microvascular complications of diabetes 1 29.1 CXCL8 ICAM1 MMP9
10 vascular disease 28.9 ACE APOE CRP MMP9 MTHFR SELP
11 stroke, ischemic 28.8 ACE APOE CRP F7 MTHFR SELP
12 pneumonia 28.6 CRP CXCL8 TNF TREM1
13 heart disease 28.4 ACE APOE CRP F7 MTHFR TNF
14 ischemic heart disease 28.2 ACE APOE CRP F7 MTHFR TNF
15 arteries, anomalies of 27.8 ACE APOE CRP ICAM1 MMP9 MTHFR
16 sleep apnea 27.4 ACE APOE CRP CXCL8 ICAM1 S100B
17 cerebrovascular disease 26.7 ACE APOE CRP F7 ICAM1 MMP9
18 moyamoya disease 2 11.3
19 moyamoya disease 5 11.1
20 moyamoya disease 6 with achalasia 11.1
21 spastic entropion 10.5 MMP1 MMP9
22 chronic actinic dermatitis 10.5 MMP1 MMP9
23 lentigo maligna melanoma 10.5 MMP9 S100B
24 cerebritis 10.4
25 diabetic foot ulcers 10.4 CRP MMP9
26 moderate and severe traumatic brain injury 10.4 ACE APOE
27 osteoporotic fracture 10.4 MTHFR TNFRSF11B
28 periodontitis, chronic 10.4 MMP1 TNFRSF11B
29 adenomyosis 10.4 MMP1 MMP9 SPP1
30 squamous cell carcinoma of the hypopharynx 10.4 MMP1 MMP9
31 odontogenic myxoma 10.3 MMP1 MMP9 S100B
32 uremia 10.3 CRP SPP1 TNFRSF11B
33 mesenteric vascular occlusion 10.3 F7 MTHFR
34 vibratory urticaria 10.3 CXCL8 MMP9
35 chronic meningitis 10.3 CRP MMP9
36 mastoiditis 10.3 CRP MTHFR
37 aortic atherosclerosis 10.2 ACE APOE SPP1
38 varicose veins 10.2 MMP1 MMP9 MTHFR
39 hypertensive heart disease 10.2 ACE MMP1 MMP9
40 exfoliation syndrome 10.2 APOE MMP1 MTHFR
41 intermediate coronary syndrome 10.2 ACE CRP SELP
42 acute transverse myelitis 10.2 CXCL8 MMP9
43 portal vein thrombosis 10.2 F7 MTHFR SELP
44 autoimmune myocarditis 10.2 SPP1 TNF
45 internal hemorrhoid 10.2 MMP1 MMP9
46 acute cholangitis 10.2 CRP TREM1
47 systemic scleroderma 10.2 ACE CRP SELP
48 cerebral atherosclerosis 10.1 ACE APOE MTHFR
49 lipid metabolism disorder 10.1 ACE APOE CRP
50 cholesteatoma 10.1 MMP9 TNF TNFRSF11B

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to Carotid Stenosis

Symptoms & Phenotypes for Carotid Stenosis

MGI Mouse Phenotypes related to Carotid Stenosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 ACE APOE CRP F7 HABP2 ICAM1
2 cardiovascular system MP:0005385 10.13 ACE APOE CRP F7 ICAM1 MMP9
3 growth/size/body region MP:0005378 10.1 ACE APOE F7 ICAM1 MMP9 MTHFR
4 immune system MP:0005387 10.1 ACE APOE CRP HABP2 ICAM1 MMP1
5 mortality/aging MP:0010768 9.9 ACE APOE F7 HABP2 ICAM1 MMP9
6 integument MP:0010771 9.86 MMP9 MTHFR APOE ICAM1 S100B SELP
7 neoplasm MP:0002006 9.5 ACE ICAM1 MMP1 MMP9 SPP1 TNF
8 skeleton MP:0005390 9.28 APOE F7 MMP9 MTHFR SELP SPP1

Drugs & Therapeutics for Carotid Stenosis

Drugs for Carotid Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 172)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
2
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
9
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
10
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
11
Losartan Approved Phase 4 114798-26-4 3961
12
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
13
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
14 tannic acid Approved, Nutraceutical Phase 4,Phase 3
15 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
16 Antimetabolites Phase 4,Phase 3,Phase 2
17 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
18 Calcium, Dietary Phase 4,Phase 3,Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
20 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
22 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
23 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
24 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
25 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
26 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2
27 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2
28 Protective Agents Phase 4,Phase 2
29 Analgesics Phase 4,Phase 2
30 Anesthetics Phase 4,Phase 2
31 Peripheral Nervous System Agents Phase 4,Phase 2
32 Analgesics, Non-Narcotic Phase 4,Phase 2
33 Antipyretics Phase 4,Phase 2
34 Anti-Inflammatory Agents Phase 4,Phase 2
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
36 Antirheumatic Agents Phase 4,Phase 2
37 Cyclooxygenase Inhibitors Phase 4,Phase 2
38 Adrenergic Agents Phase 4,Phase 2
39 Adrenergic Agonists Phase 4
40 Adrenergic alpha-Agonists Phase 4
41 Fluorodeoxyglucose F18 Phase 4
42 Radiopharmaceuticals Phase 4
43 Antioxidants Phase 4,Phase 2
44 Central Nervous System Depressants Phase 4
45 Analgesics, Opioid Phase 4
46 Anesthetics, General Phase 4
47 Anesthetics, Inhalation Phase 4
48 Anesthetics, Intravenous Phase 4
49 Hypnotics and Sedatives Phase 4
50 Narcotics Phase 4

Interventional clinical trials:

(show top 50) (show all 209)

# Name Status NCT ID Phase Drugs
1 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
2 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
3 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
4 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Completed NCT00772278 Phase 4
5 Melatonin in Patients Under Carotid Endarterectomy Completed NCT03115034 Phase 4 Melatonin;placebo
6 Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy Completed NCT02609087 Phase 4 Sevoflurane;Propofol
7 Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery Completed NCT01146301 Phase 4 Clopidogrel
8 Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study) Completed NCT00287508 Phase 4
9 A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease Completed NCT00178672 Phase 4
10 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
11 Insulin Resistance in Patients After Carotid Revascularization Recruiting NCT03419767 Phase 4 Melatonin
12 High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting Not yet recruiting NCT03079115 Phase 4 High-dose Atorvastatin;Conventional-dose Atorvastatin
13 Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis Terminated NCT00805311 Phase 4 atorvastatin, aspirin, losartan, amlodipine
14 Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA Terminated NCT00478673 Phase 4
15 The Effects of Dexmedetomidine and Remifentanil on Carotid Patients Terminated NCT00335972 Phase 4 Remifentanil;Dexmedetomidine
16 Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Terminated NCT01236508 Phase 4
17 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
18 EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
19 ViVEXX Carotid Revascularization Trial (VIVA) Completed NCT00417963 Phase 3
20 Carotid Artery Stenting With Protection Registry Completed NCT00318851 Phase 3
21 Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects Completed NCT00654394 Phase 3 Rosuvastatin
22 Gadobutrol Enhanced MRA of the Supra-aortic Vessels Completed NCT01344447 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
23 GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN) Completed NCT00766493 Phase 3
24 SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy Completed NCT01591005 Phase 3
25 GORE Embolic Protection With Reverse Flow Completed NCT00594100 Phase 3
26 Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease Completed NCT02260453 Phase 3
27 IMaging Della PLAcca Carotidea Completed NCT03333330 Phase 3 Visipaque 320 and SonoVue
28 Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent Completed NCT02529345 Phase 2, Phase 3
29 Carotid Revascularization With ev3 Arterial Technology Evolution (CREATE) Trial Completed NCT00619775 Phase 3
30 ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" Completed NCT00180518 Phase 2, Phase 3
31 Clopidogrel Resistance and Embolism in Carotid Artery Stenting Recruiting NCT02133989 Phase 3 Ticlopidine + Ginko biloba;Clopidogrel
32 Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting NCT02850081 Phase 3 Statin;Atorvastatin
33 " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " Not yet recruiting NCT02841098 Phase 3 Optimal medical therapy alone
34 Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis Terminated NCT00126139 Phase 3 Abciximab
35 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
36 Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy Terminated NCT01415648 Phase 3
37 Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant Terminated NCT00228176 Phase 3 Rimonabant;Placebo (for Rimonabant)
38 Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis Unknown status NCT01923012 Phase 2 Vitamin K2 (Menaquinone)
39 The Use of Anti-CD4 mAb-Fragment for Imaging of Local Inflammation in Patients With Carotid Artery Stenosis Unknown status NCT00904254 Phase 2
40 Cost-Effectiveness of a Specialized Ultrasound Instrument to Diagnose Carotid Stenosis as a Way to Reduce the Risk of Stroke Completed NCT00417586 Phase 1, Phase 2
41 Recurrent Carotid Stenosis Completed NCT00000527 Phase 2 aspirin;dipyridamole
42 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting Completed NCT01654666 Phase 2
43 Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy Completed NCT00352417 Phase 2 VIA-2291;Placebo
44 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
45 Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols Completed NCT00753532 Phase 2
46 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Recruiting NCT01645306 Phase 2 Revacept;Placebo
47 Ticagrelor Versus Clopidogrel in Carotid Artery Stenting Recruiting NCT02677545 Phase 2 Ticagrelor;Clopidogrel;Aspirin
48 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis Recruiting NCT02667457 Phase 2
49 New Technologies to Determine Carotid Plaque Vulnerability in Patients With Significant Carotid Plaques Recruiting NCT03335033 Phase 2
50 Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke Recruiting NCT02513589 Phase 2 18F-PBR06

Search NIH Clinical Center for Carotid Stenosis

Cochrane evidence based reviews: carotid stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

MalaCards organs/tissues related to Carotid Stenosis:

38
Brain, Heart, Endothelial, Liver, Eye, Myeloid, T Cells

Publications for Carotid Stenosis

Articles related to Carotid Stenosis:

(show top 50) (show all 668)
# Title Authors Year
1
Comparative analysis of 3D time-resolved contrast-enhanced magnetic resonance angiography, color Doppler ultrasound and digital subtraction angiography in symptomatic carotid stenosis. ( 29434750 )
2018
2
Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis. ( 29327345 )
2018
3
Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis. ( 29305337 )
2018
4
Cavernous carotid stenosis following stereotactic radiosurgery for Cushing's disease: A rare complication and review of the literature. ( 29097132 )
2018
5
Carotid stenosis - basing treatment on individual patients' needs. Optimal medical therapy alone or accompanied by stenting or endarterectomy. ( 29064776 )
2018
6
High intensity signal in the plaque on routine 3D-TOF MRA is associated with ischemic stroke in the patients with low-grade carotid stenosis. ( 29406899 )
2018
7
Stroke chameleon (cortical hand syndrome) in a patient with moderate carotid stenosis: a neurological double-trouble. ( 29372407 )
2018
8
Increased variability of watershed areas in patients with high-grade carotid stenosis. ( 29299616 )
2018
9
Embolic Protection Device in Asymptomatic Carotid Stenosis. ( 29378420 )
2018
10
Carotid Artery Stenting Has a Role in the Management of Asymptomatic Carotid Stenosis, but This Is Currently Small. ( 29390866 )
2018
11
Accuracy of Carotid Duplex Criteria in Diagnosis of Significant Carotid Stenosis in Asian Patients. ( 29153302 )
2018
12
Clinical need, design, and goals for the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis trial. ( 28818255 )
2017
13
Reply to Letter to the Editor "Carotid Endarterectomy Versus Stenting to Treat Carotid Stenosis: There is More to Than Meets the Eye". ( 28742693 )
2017
14
Endarterectomy achieves lower stroke and death rates compared with stenting in patients with asymptomatic carotid stenosis. ( 28735954 )
2017
15
Surgical Treatment of Significant Asymptomatic Carotid Stenosis: for the Motion. ( 28985661 )
2017
16
Carotid Stenosis and Impaired Cognition: The Effect of Intervention. ( 28786896 )
2017
17
Surgical and Endovascular Treatment of Extracranial Carotid Stenosis. ( 29143732 )
2017
18
Automatic flow analysis of digital subtraction angiography using independent component analysis in patients with carotid stenosis. ( 28949999 )
2017
19
How asymptomatic is "asymptomatic" carotid stenosis? Resolving fundamental confusion(s) - and confusions yet to be resolved. ( 29192895 )
2017
20
Pooled RCTs: In symptomatic carotid stenosis, endarterectomy had lower periprocedural risk than stenting. ( 29049764 )
2017
21
Optimal management of patients with asymptomatic carotid stenosis. ( 28784641 )
2017
22
Asymptomatic carotid stenosis is associated with cognitiveA impairment. ( 28712815 )
2017
23
Symptomatic carotid stenosis: is stenting as safe and effective as carotid endarterectomy? ( 28002121 )
2017
24
The Impact of Carotid Artery Stenting on Cerebral Perfusion, Functional Connectivity, and Cognition in Severe Asymptomatic Carotid Stenosis Patients. ( 28848495 )
2017
25
Asymptomatic Carotid Stenosis in Cardiac Surgery Patients: Is Less More? ( 28916669 )
2017
26
Extracranial carotid stenosis: evidence based review. ( 28767806 )
2017
27
Carotid Endarterectomy Versus Carotid Stenting to Treat Carotid Stenosis: There Is More to Than Meets the Eye. ( 28742705 )
2017
28
Which patients with asymptomatic carotid stenosis benefit from revascularization? ( 27875340 )
2017
29
Circulating MicroRNAs as Novel Biomarkers of Stenosis Progression in Asymptomatic Carotid Stenosis. ( 27899750 )
2017
30
The fate of asymptomatic severe carotid stenosis in the era of best medical therapy. ( 28816542 )
2017
31
Mesh-covered (Roadsaver) stent as a new treatment modality for symptomatic or high-risk carotid stenosis. ( 28798783 )
2017
32
Severe contralateral carotid stenosis or occlusion does not have an impact on risk of ipsilateral stroke after carotid endarterectomy. ( 29242067 )
2017
33
Ethnicity, Race, and Post-Operative Stroke Risk among 53,593 Patients with Asymptomatic Carotid Stenosis Undergoing Revascularization. ( 28890012 )
2017
34
Visual Aids for Improving Patient Decision Making in Severe Symptomatic Carotid Stenosis. ( 28797613 )
2017
35
The risk of ischemic events increased in patients with asymptomatic carotid stenosis with decreased cerebrovascular reserve. ( 28716984 )
2017
36
3-Dimensional Ultrasound in Carotid Stenosis Quantitation and Beyond. ( 28734910 )
2017
37
Recommendations for Low-Grade Carotid Stenosis Follow-up Based on a Single-Institution Database. ( 28877387 )
2017
38
Transradial Stenting for Carotid Stenosis in Patients with Bovine Type and Type III Aortic Arch: Experience in 28 Patients. ( 29294393 )
2017
39
Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels. ( 28495179 )
2017
40
Prolonged cerebral circulation time is more associated with symptomatic carotid stenosis than stenosis degree or collateral circulation. ( 28855347 )
2017
41
Mild Carotid Stenosis with Recurrent Symptoms Triggered by Eating. ( 27989985 )
2017
42
Influence of Severe Carotid Stenosis on Cognition, Depressive Symptoms and Quality of Life. ( 29238393 )
2017
43
Cerebral Infarct Topography and Early Outcome after Surgery for Symptomatic Carotid Stenosis: A Multicentre Study. ( 28910807 )
2017
44
Autonomic outcome is better after endarterectomy than after stenting in patients with asymptomatic carotid stenosis. ( 27353359 )
2016
45
Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis. ( 26886419 )
2016
46
Intervention versus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis. ( 27127004 )
2016
47
Randomized Clinical Trial of Endovascular Stenting vs Endarterectomy for Treatment of Severe Carotid Stenosis. ( 27428641 )
2016
48
Finding the optimal deconvolution algorithm for MR perfusion in carotid stenosis: Correlations with angiographic cerebral circulation time. ( 27038737 )
2016
49
Endovascular Stenting versus Carotid Endarterectomy for Treatment of Severe Carotid Stenosis: Recent Results from ACT I and the Updated CREST Studies. ( 27262649 )
2016
50
Convexity subarachnoid haemorrhage secondary to internal carotid stenosis: an indication for revascularisation. ( 27118746 )
2016

Variations for Carotid Stenosis

Expression for Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for Carotid Stenosis

Pathways related to Carotid Stenosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 CXCL8 ICAM1 MMP9 TNF
2
Show member pathways
12.4 ACE CXCL8 SPP1 TNF
3
Show member pathways
12.18 CXCL8 MMP1 MMP9 TNF
4
Show member pathways
12.06 CXCL8 ICAM1 MMP1 MMP9 SPP1
5 11.82 ICAM1 MMP9 TNF
6 11.77 CXCL8 ICAM1 TNF
7
Show member pathways
11.77 APOE CRP F7 ICAM1 MTHFR TNF
8
Show member pathways
11.76 MMP1 MMP9 TNF
9 11.74 CXCL8 ICAM1 TNF
10 11.73 CXCL8 ICAM1 MMP1 TNF
11 11.73 CXCL8 ICAM1 MMP9 SELP TNF
12 11.67 CXCL8 ICAM1 MMP1
13 11.61 CXCL8 MMP1 MMP9
14 11.61 CXCL8 ICAM1 MMP1 MMP9 TNF
15 11.53 CXCL8 MMP9 SPP1 TNF
16 11.5 CXCL8 MMP1 MMP9
17 11.4 CXCL8 ICAM1 SELP TNF
18 11.39 CXCL8 ICAM1 TNF
19 11.35 ICAM1 MMP9 SELP TNF
20 11.28 APOE SPP1 TNF TNFRSF11B
21 11.22 CXCL8 MMP1 MMP9
22 11.18 ACE APOE MMP9
23 10.91 CRP CXCL8 TNF
24 10.86 MMP1 MMP9
25 10.83 ICAM1 TNF
26 10.82 SPP1 TNFRSF11B
27
Show member pathways
10.82 CXCL8 ICAM1 MMP1 MMP9 TNF

GO Terms for Carotid Stenosis

Cellular components related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ACE APOE CRP CXCL8 F7 HABP2
2 extracellular matrix GO:0031012 9.56 APOE ICAM1 MMP1 MMP9
3 external side of plasma membrane GO:0009897 9.46 ACE ICAM1 SELP TNF
4 extracellular space GO:0005615 9.44 ACE APOE CRP CXCL8 F7 HABP2

Biological processes related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.55 ICAM1 MMP9 SPP1 TNF TNFRSF11B
2 extracellular matrix disassembly GO:0022617 9.54 MMP1 MMP9 SPP1
3 embryonic digestive tract development GO:0048566 9.46 CXCL8 TNF
4 leukocyte tethering or rolling GO:0050901 9.43 SELP TNF
5 inflammatory response GO:0006954 9.43 CRP CXCL8 SELP SPP1 TNF TNFRSF11B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.4 APOE TNF
7 negative regulation of lipid storage GO:0010888 9.32 CRP TNF
8 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.26 ICAM1 TNF
9 leukocyte migration GO:0050900 9.1 ICAM1 MMP1 MMP9 SELP TNF TREM1

Molecular functions related to Carotid Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.77 CRP F7 HABP2 S100B SELP
2 serine-type endopeptidase activity GO:0004252 9.56 F7 HABP2 MMP1 MMP9
3 peptidase activity GO:0008233 9.55 ACE F7 HABP2 MMP1 MMP9
4 tau protein binding GO:0048156 9.32 APOE S100B
5 cytokine activity GO:0005125 9.26 CXCL8 SPP1 TNF TNFRSF11B
6 endopeptidase activity GO:0004175 8.92 ACE F7 MMP1 MMP9

Sources for Carotid Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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