MCID: CRT013
MIFTS: 46

Carotid Stenosis malady

Summaries for Carotid Stenosis

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Wikipedia:65 Carotid stenosis is a narrowing or constriction of the inner surface (lumen) of the carotid artery,... more...

MalaCards based summary: Carotid Stenosis, also known as carotid artery stenosis, is related to ischemia and coronary artery disease. An important gene associated with Carotid Stenosis is HABP2 (hyaluronan binding protein 2), and among its related pathways are IL-3 Signaling Pathway and amb2 Integrin signaling. The compounds sele and lxa4 have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Carotid Stenosis

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Carotid Stenosis, Aliases & Descriptions:

Name: Carotid Stenosis 10 12 45 62
Carotid Artery Stenosis 10 62
 
Carotid Stenosis, Susceptibility to 11
Stenosis, Carotid Artery 10


External Ids:

Disease Ontology10 DOID:13001
SNOMED-CT57 64586002, 195181000
MeSH35 D016893

Related Diseases for Carotid Stenosis

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Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.7FABP2, PON1, SELP
2coronary artery disease30.5SELP, PON1
3hepatitis30.5PON1, SELP
4abdominal aortic aneurysm30.5MMP1, MMP9
5vascular disease30.4MMP9, PON1, SELP
6hyperhomocysteinemia30.1PON1, SELP
7cerebrovascular disease30.0SELP, PON1, FABP2
8breast cancer30.0MMP9, HABP2, MMP1
9atherosclerosis29.9PON1, HABP2, SELP, FABP2, MMP1, MMP9
10cerebritis10.8
11cervicitis10.5
12artery disease10.4
13intracranial aneurysm10.4
14aneurysm10.4
15atrial fibrillation10.4
16retinitis10.3
17aortic aneurysm10.3
18peripheral vascular disease10.3
19neuronitis10.2
20carotid artery disease10.2
21cholesterol embolism10.2
22retinal artery occlusion10.2
23sleep apnea10.2
24autonomic dysfunction10.2
25blindness10.2
26tetralogy of fallot10.2
27moyamoya disease 210.2
28sinusitis10.2
29pituitary apoplexy10.2
30oral squamous cell carcinoma10.2
31aortitis10.2
32tracheal stenosis10.2
33subclavian steal syndrome10.2
34brain stem infarction10.2
35hepatic encephalopathy10.2
36kidney disease10.2
37mediastinitis10.2
38arteriosclerosis10.0PON1
39synovitis10.0MMP1
40thrombophilia due to thrombin defect10.0HABP2, SELP
41coronary stenosis10.0PON1, SELP
42antiphospholipid syndrome10.0PON1, SELP
43insulin-like growth factor i10.0
44intermittent claudication10.0
45ischemic heart disease10.0
46retinal ischemia10.0
47status epilepticus10.0
48renovascular hypertension10.0
49tympanosclerosis10.0
50peripheral artery disease10.0

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to carotid stenosis

Symptoms for Carotid Stenosis

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Drugs & Therapeutics for Carotid Stenosis

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Drug clinical trials:

Search ClinicalTrials for Carotid Stenosis

Search NIH Clinical Center for Carotid Stenosis

Genetic Tests for Carotid Stenosis

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Anatomical Context for Carotid Stenosis

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MalaCards organs/tissues related to Carotid Stenosis:

33
Brain, Heart, Bone, Smooth muscle, Breast, T cells, Endothelial

Animal Models for Carotid Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Carotid Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1IL12A, FABP2, MMP1, MMP9, PON1, SELP

Publications for Carotid Stenosis

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Articles related to Carotid Stenosis:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Emergency stenting for acute symptomatic carotid stenosis: dissecting the evidence. (25720774)
2015
2
Revascularization of asymptomatic carotid stenosis is not appropriate in patients on dialysis. (25720927)
2015
3
Endovascular advances for extracranial carotid stenosis. (24402498)
2014
4
Long-term follow-up study of endarterectomy versus angioplasty in patients with symptomatic severe carotid stenosis trial. (25082808)
2014
5
Safety and effectiveness of emergency carotid artery stenting for a high-grade carotid stenosis with intraluminal thrombus under proximal flow control in hyperacute and acute stroke. (22170821)
2013
6
Treatment of symptomatic carotid stenosis: carotid stent placement versus endarterectomy. (23873312)
2013
7
The analysis of the connection between plaque morphology of asymptomatic carotid stenosis and ischemic brain lesions. (24397192)
2013
8
Reversal of ophthalmic artery flow and stroke outcomes in asian patients with acute ischemic stroke and unilateral severe cervical carotid stenosis. (24312492)
2013
9
Quantitative flow measurement by digital subtraction angiography in cerebral carotid stenosis using optical flow method. (23694912)
2013
10
A randomized trial of decision-making in asymptomatic carotid stenosis. (22218277)
2012
11
Secondary stroke prevention: patent foramen ovale, aortic plaque, and carotid stenosis. (22422912)
2012
12
Identifying high-risk asymptomatic carotid stenosis. (23480656)
2012
13
Carotid stenosis treatments compared. Both surgical and nonsurgical options can prevent stroke. (23437463)
2012
14
Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. (22935402)
2012
15
Higher incidence of carotid stenosis in patients with central retinal artery occlusion. (20384592)
2011
16
Controversies in neurology: asymptomatic carotid stenosis--intervention or just stick to medical therapy. The argument for carotid endarterectomy. (21298296)
2011
17
Update on surgical management for asymptomatic carotid stenosis. (20922504)
2011
18
Asymptomatic carotid stenosis: screening and management. (21667597)
2011
19
Treatment strategies for carotid stenosis in patients at increased risk for surgery. (21722783)
2011
20
Short-term outcome after stenting versus endarterectomy for symptomatic carotid stenosis: a preplanned meta-analysis of individual patient data. (20832852)
2010
21
Inraoperative and Histological Visualization of Disrupted Vulnerable Plaques following Diagnostic Angiography of Moderate Carotid Stenosis. (20700419)
2010
22
Cerebral reserve is decreased in elderly patients with carotid stenosis. (20620003)
2010
23
Extracranial carotid stenosis and peripheral arterial disease in Thai patients with coronary artery disease. (20483809)
2010
24
Reproducibility of semi-automated measurement of carotid stenosis on CTA. (20724259)
2010
25
Stroke: Carotid stenosis--surgery or stenting to prevent stroke? (21131910)
2010
26
How should physicians practically approach symptomatic and asymptomatic carotid stenosis? (20726212)
2010
27
Cardiac surgery, carotid stenosis, and stroke prevention. (20469611)
2010
28
Central sleep apnea indicates autonomic dysfunction in asymptomatic carotid stenosis: a potential marker of cerebrovascular and cardiovascular risk. (20337190)
2010
29
Two cases of branch retinal arterial occlusion after carotid artery stenting in the carotid stenosis. (19337482)
2009
30
Prevalence of carotid stenosis in a high-risk Caribbean population. (19246696)
2009
31
Strokes after cardiac surgery and relationship to carotid stenosis. (19752298)
2009
32
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis. (19416961)
2009
33
High risk of early neurological recurrence in symptomatic carotid stenosis. (19498196)
2009
34
High cardiovascular event rates in patients with asymptomatic carotid stenosis: the REACH Registry. (19473362)
2009
35
Does metabolic syndrome predict silent carotid stenosis in coronary patients? (18283528)
2008
36
Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. (19012726)
2008
37
Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial. (18774745)
2008
38
Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting. (18486427)
2008
39
How asymptomatic is asymptomatic carotid stenosis? (17581914)
2007
40
Current status of carotid endarterectomy and stenting for symptomatic carotid stenosis. (17971647)
2007
41
Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from the ACSRS study. Nicolaides et al.: EJVES 2005; 30: 275-284. (16359888)
2006
42
Accuracy of angiography and Doppler ultrasonography in the detection of carotid stenosis: a histopathological study of 123 cases. (16523222)
2006
43
Accurate, practical and cost-effective assessment of carotid stenosis in the UK. (16904049)
2006
44
Atherosclerotic carotid stenosis and occlusion. (17290125)
2006
45
Recurrent carotid stenosis after angioplasty and stenting. (15874940)
2005
46
Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Results from the helsinki carotid endarterectomy study. (15775709)
2005
47
Commentary. Carotid angioplasty and stenting versus carotid endarterectomy for treatment of asymptomatic carotid stenosis: a randomized trial in a community hospital. (15952703)
2005
48
Carotid stenosis measurement on colour Doppler ultrasound: agreement of ECST, NASCET and CCA methods applied to ultrasound with intra-arterial angiographic stenosis measurement. (15964165)
2005
49
Adhesion molecule expression in symptomatic and asymptomatic carotid stenosis. (12821729)
2003
50
An angiotensin-converting enzyme gene polymorphism suggests a genetic distinction between ischaemic stroke and carotid stenosis. (10354208)
1999

Variations for Carotid Stenosis

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Expression for genes affiliated with Carotid Stenosis

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Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for genes affiliated with Carotid Stenosis

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Compounds for genes affiliated with Carotid Stenosis

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Compounds related to Carotid Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1sele4510.0SELP, PON1
2lxa4459.9MMP1, SELP
3clopidogrel45 51 26 1312.8PON1, SELP
4cgs-27023a459.8MMP1, MMP9
5prinomastat459.8MMP9, MMP1
6ilomastat459.8MMP1, MMP9
7latanoprost45 1310.7MMP1, MMP9
88-isoprostane459.7PON1, MMP9
9candesartan45 51 30 1312.7SELP, MMP1
10cilomilast459.7MMP1, MMP9
11(4-aminophenyl)mercuric acetate459.7MMP9, MMP1
12quinacrine45 1310.7MMP1, SELP
13gm 6001619.7MMP1, MMP9
14gi 254023x619.7MMP1, MMP9
15uk 383367619.7MMP1, MMP9
16geranylgeranyl pyrophosphate459.7MMP1, MMP9
17hydroxamate459.6MMP1, MMP9
18marimastat45 61 1311.6MMP9, MMP1
19zoledronic acid459.6MMP9, MMP1
201,10-phenanthroline45 310.6MMP1, MMP9
21ns 39845 6110.5MMP1, MMP9
22simvastatin45 51 61 30 26 1314.5SELP, PON1, MMP9
23batimastat45 61 1311.4MMP1, MMP9
24pravastatin45 51 30 26 1313.4MMP1, PON1, SELP
25dextran sulfate459.4SELP, HABP2
26aspirin45 51 30 2612.4MMP1, PON1, SELP
27hyaluronic acid45 2610.4MMP1, MMP9, HABP2
28aprotinin45 1310.4MMP1, MMP9, SELP
29hydroxyproline45 26 1311.3MMP1, MMP9
30formaldehyde45 2610.3MMP1, MMP9, SELP
31alpha tocopherol459.3MMP1, MMP9, PON1
32rantes459.3MMP1, MMP9, SELP
33epinephrine45 26 1311.3SELP, MMP9, MMP1
34rosiglitazone30 45 51 26 1313.3PON1, MMP9, MMP1
35n acetylcysteine459.3SELP, MMP9, MMP1
36norepinephrine45 26 1311.2MMP1, MMP9, SELP
37fibrinogen459.2MMP9, PON1, SELP, HABP2
38genistein45 30 61 3 26 1314.1SELP, MMP9, MMP1
39mycophenolate mofetil45 51 1311.1SELP, MMP1, IL12A
40fenofibrate45 51 1311.0FABP2, MMP9, PON1, SELP
41cyclosporin a45 30 6111.0MMP1, MMP9, SELP
42pge2458.9SELP, MMP9, MMP1
43fluvastatin45 51 30 1311.9SELP, PON1, MMP9, MMP1
44atorvastatin45 51 30 26 1312.9MMP1, MMP9, PON1, SELP
45lactate458.8MMP1, MMP9, SELP
46vitamin a45 26 1310.8FABP2, MMP1, MMP9, PON1
47estrogen458.8MMP1, MMP9, PON1, SELP
48retinoic acid45 269.7SELP, MMP9, MMP1, FABP2
49creatinine458.4SELP, PON1, MMP9, MMP1, FABP2
50cysteine458.4SELP, PON1, MMP9, MMP1, FABP2

GO Terms for genes affiliated with Carotid Stenosis

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Cellular components related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5MMP1, MMP9, PON1, HABP2
2extracellular spaceGO:00056157.6IL12A, MMP9, PON1, SELP, HABP2

Biological processes related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.2IL12A, SELP
2collagen catabolic processGO:00305749.2MMP1, MMP9
3extracellular matrix disassemblyGO:00226179.0MMP1, MMP9
4leukocyte migrationGO:00509008.9MMP1, MMP9, SELP

Molecular functions related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.3MMP1, MMP9

Products for genes affiliated with Carotid Stenosis

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Sources for Carotid Stenosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet