MCID: CRT013
MIFTS: 50

Carotid Stenosis malady

Summaries for Carotid Stenosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Carotid stenosis is a narrowing or constriction of the inner surface (lumen) of the carotid artery,... more...

MalaCards: Carotid Stenosis, also known as carotid stenosis, susceptibility to, is related to stroke, ischemic and abdominal aortic aneurysm. An important gene associated with Carotid Stenosis is HABP2 (hyaluronan binding protein 2), and among its related pathways are Syndecan-1-mediated signaling events and Immune response IL-12 signaling pathway. The compounds rantes and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart, and related mouse phenotype immune system.

Aliases & Classifications for Carotid Stenosis

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 9diseasecard, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

carotid stenosis 8 47 10 45 61
carotid stenosis, susceptibility to 9
stenosis, carotid artery 8
carotid artery stenosis 8


External Ids:

Disease Ontology8 DOID:13001
SNOMED-CT57 195181000, 64586002
MeSH35 D016893

Related Diseases for Carotid Stenosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1stroke, ischemic30.8MMP9, F7
2abdominal aortic aneurysm30.4TNFRSF11B, MMP1, MMP9
3vascular disease30.3SELP
4coronary artery disease,30.3GNB3, TNFRSF11B, PON1, F7, MMP9, SELP
5thromboembolism30.0SELP, F7, HABP2
6hyperhomocysteinemia30.0SELP, PON1
7atherosclerosis30.0GNB3, TNFRSF11B, FABP2, HABP2, PON1, F7
8intracranial aneurysm10.3
9carotid artery occlusion10.3
10aortic aneurysm10.3
11peripheral vascular disease10.2
12takayasu's arteritis10.1
13autonomic dysfunction10.1
14sleep apnea10.1
15blindness10.1
16moyamoya disease10.1
17tracheal stenosis10.1
18pituitary apoplexy10.1
19aortitis10.1
20brain stem infarction10.1
21squamous cell carcinoma10.1
22oral squamous cell carcinoma10.1
23cerebral atrophy10.1
24sinusitis10.1
25central retinal artery occlusion10.0
26branch retinal artery occlusion10.0
27proliferative diabetic retinopathy10.0
28subclavian steal syndrome10.0
29tympanosclerosis10.0
30renovascular hypertension10.0
31status epilepticus10.0
32patent foramen ovale10.0
33cerebral artery occlusion10.0
34retinal ischemia10.0
35brain edema10.0
36intermittent claudication10.0
37central sleep apnea10.0
38protein s deficiency10.0
39cortical blindness10.0
40rubeosis iridis10.0
41protein c deficiency10.0
42amaurosis fugax10.0
43carotid body tumor10.0
44fibromuscular dysplasia10.0
45lip disease10.0
46polycystic ovary syndrome10.0PON1
47galactosemia10.0F7
48lung cancer10.0MMP9
49kawasaki disease10.0MMP9
50diabetic retinopathy10.0PON1

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to carotid stenosis

Clinical Features for Carotid Stenosis

Drugs & Therapeutics for Carotid Stenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Carotid Stenosis

Drug clinical trials:

Search ClinicalTrials for Carotid Stenosis

Search NIH Clinical Center for Carotid Stenosis

Search CenterWatch for Carotid Stenosis

Genetic Tests for Carotid Stenosis

Anatomical Context for Carotid Stenosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Carotid Stenosis:

33
Brain, Kidney, Heart, Smooth muscle, Breast, T cells, B cells, Endothelial, Pituitary

Animal Models for Carotid Stenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Carotid Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.5SELP, BIRC3, MMP9, IL12A, IL12B, DUSP2

Publications for Carotid Stenosis

Sources:
51PubMed
See all sources

Articles related to Carotid Stenosis:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Endovascular advances for extracranial carotid stenosis. (24402498)
2014
2
Clinical practice. Carotid stenosis. (24047063)
2013
3
Early results after synchronous carotid stent placement and coronary artery bypass graft in patients with asymptomatic carotid stenosis. (23336857)
2013
4
Carotid artery stenting in patients with acute coronary syndrome: a possible primary therapy for symptomatic carotid stenosis. (23914865)
2013
5
Validating common carotid stenosis by duplex ultrasound with carotid angiogram or computed tomography scan. (24080127)
2013
6
Carotid stenosis. (24328482)
2013
7
Ultrasonographic markers of vascular risk in patients with asymptomatic carotid stenosis. (23361391)
2013
8
Diabetes does not affect outcome of symptomatic carotid stenosis treated with endovascular techniques. (23429066)
2013
9
Does medical specialty influence the treatment of asymptomatic carotid stenosis? a Belgian multidisciplinary survey. (21460764)
2011
10
N-terminal pro B-type natriuretic peptide (NT pro-BNP) is a predictor of long-term survival in male patients of 75 years and older with high-grade asymptomatic internal carotid artery stenosis. (21215559)
2011
11
Asymptomatic Carotid Stenosis: Identifying Patients at High Enough Risk to Warrant Endarterectomy or Stenting. (21799163)
2011
12
Carotid shunt provides cerebral protection during emergency coronary artery bypass grafting in a patient with bilateral high grade carotid stenosis: a case report. (21418607)
2011
13
Ultrasound screening for asymptomatic carotid stenosis in subjects with calcifications in the area of the carotid arteries on panoramic radiographs: a cross-sectional study. (21752238)
2011
14
Prevalence of asymptomatic carotid stenosis in Korea based on health screening population. (21935272)
2011
15
Letter by Wong and Poon regarding article, "Does impaired cerebrovascular reactivity predict stroke risk in asymptomatic carotid stenosis? A prospective substudy of the Asymptomatic Carotid Emboli Study (ACES)". (21852610)
2011
16
Asymptomatic carotid stenosis: intervention or just stick to medical therapy--the case for medical therapy. (21301896)
2011
17
Treatment of carotid stenosis in octogenarians: stenting or surgery? (21515490)
2011
18
Inraoperative and Histological Visualization of Disrupted Vulnerable Plaques following Diagnostic Angiography of Moderate Carotid Stenosis. (20700419)
2010
19
Stroke: Carotid stenosis--surgery or stenting to prevent stroke? (21131910)
2010
20
Interrelation between the degree of carotid stenosis, collateral circulation and cerebral perfusion. (20664261)
2010
21
Contemporary results of carotid endarterectomy for asymptomatic carotid stenosis. (20339122)
2010
22
Standardized ultrasound evaluation of carotid stenosis for clinical trials: University of Washington Ultrasound Reading Center. (20822530)
2010
23
Diagnostic workup in carotid stenosis-a neurologist's perspective. (20405113)
2010
24
Ongoing randomized controlled trials comparing interventional methods and optimal medical treatment in the treatment of asymptomatic carotid stenosis. (21030708)
2010
25
Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis. (19540657)
2009
26
Association between carotid and coronary artery disease in patients with aortic valve stenosis: an angiographic study. (19049997)
2009
27
Underestimation of carotid stenosis in bradycardia. (19344584)
2009
28
Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting. (18486427)
2008
29
Low incidence of symptomatic strokes after carotid stenting without embolization protection devices for extracranial carotid stenosis: a single-institution retrospective review. (19005376)
2008
30
Genetic control of chemokines in severe human internal carotid artery stenosis. (18060801)
2008
31
Blood pressure control in patients with a symptomatic carotid artery stenosis]. (19102437)
2008
32
A three-dimensional ultrasonographic quantitative analysis of non-ulcerated carotid plaque morphology in symptomatic and asymptomatic carotid stenosis. (18221743)
2008
33
Stenosis of the proximal external carotid artery in an adult with moyamoya disease: moyamoya or atherosclerotic change? (17721051)
2007
34
Variability of clinical CT perfusion measurements in patients with carotid stenosis. (17646976)
2007
35
Carotid stenting: looking beyond the degree of carotid stenosis. (17611484)
2007
36
Is stenting a safe alternative to endarterectomy in patients with severe symptomatic carotid stenosis? (17297490)
2007
37
Facial cutaneous cholesterol embolism revealing a tight carotid stenosis: a case report. (17067829)
2007
38
Levels and value of platelet activity in patients with severe internal carotid artery stenosis. (16567695)
2006
39
Carotid angioplasty and stent placement for the treatment of carotid stenosis: past, present, and future. (18706067)
2006
40
Massive stroke in a patient with pituitary apoplexy, cervical carotid artery stenosis and hypotension. (17041531)
2006
41
Spontaneous resolution of carotid stenosis--a case for routine preoperative duplex ultrasound. (16376122)
2006
42
Endovascular treatment for recurrent carotid stenosis in a patient with proatlantal intersegmental artery. (16517790)
2006
43
Changes in flow-mediated dilatation, cytokines and carotid arterial stenosis during aggressive atorvastatin treatment in normocholesterolemic patients. (15759815)
2005
44
Carotid stenosis degree in CT angiography: assessment based on luminal area versus luminal diameter measurements. (16228216)
2005
45
Letter regarding article by Markus et al, "Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic cardiac stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial". (16286597)
2005
46
The need for urgency in identification and treatment of symptomatic carotid stenosis is already established. (15838162)
2005
47
Factors affecting recurrent carotid stenosis. (15696251)
2005
48
Petrous carotid canal stenosis in malignant osteopetrosis: CT documentation with MR angiographic correlation. (8668787)
1996
49
Cerebral ischemia in a patient with protein S deficiency and carotid stenosis. (8056555)
1994
50
Amaurosis fugax as a symptom of carotid artery stenosis. Its relationship with ulcerated plaque. (8120072)
1994

Genetic Variations for Carotid Stenosis

Expression for genes affiliated with Carotid Stenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for genes affiliated with Carotid Stenosis

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Carotid Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3MMP9, MMP1
210.2SELP, IL12A, IL12B
3
Hide members
10.0BIRC3, IL12A, IL12B, TNFRSF11B

Compounds for genes affiliated with Carotid Stenosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR
See all sources

Compounds related to Carotid Stenosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1rantes4510.8IL12B
2pge24510.8MMP9
3cgs-27023a4510.7MMP1, MMP9
4mdmp4510.7SELP, DUSP2
5prinomastat4510.7MMP9, MMP1
6ilomastat4510.6MMP9, MMP1
7geranylgeranyl pyrophosphate4510.6MMP9, MMP1, TNFRSF11B
8zoledronic acid4510.6MMP9, MMP1, TNFRSF11B
9mycophenolate mofetil45 50 1112.6SELP, MMP1, IL12A
10ns 39845 6011.6TNFRSF11B, MMP1, MMP9
11epinephrine45 11 2412.6SELP, GNB3
12pdmp4510.6DUSP2, SELP
13fenofibrate45 50 1112.6SELP, MMP9, PON1, FABP2
14nitroglycerin45 1111.6SELP, TNFRSF11B, GNB3
15latanoprost45 1111.6MMP1, MMP9
16pravastatin45 50 29 11 2414.6SELP, MMP1, PON1, GNB3
17lxa44510.6MMP1, SELP
18kininogen4510.5HABP2, F7, SELP
19hydroxyproline45 11 2412.5MMP9, MMP1, TNFRSF11B
20pentoxifylline45 1111.5SELP, MMP1, IL12B
21simvastatin45 50 60 29 11 2415.5GNB3, PON1, MMP9, SELP
22cilomilast4510.5MMP1, MMP9
23aprotinin45 1111.5SELP, MMP1
24vitamin a45 11 2412.5FABP2, PON1, MMP1, MMP9
25fluvastatin45 50 29 1113.5GNB3, PON1, MMP1, MMP9, SELP
26celecoxib45 60 29 50 11 2415.5MMP9, MMP1, TNFRSF11B
27glucose4510.5SERPINA12
28pdtc4510.4MMP1, MMP9, BIRC3
29aspirin45 50 29 2413.4TNFRSF11B, DUSP2, PON1, MMP1, SELP
30sb 20358045 6011.4TNFRSF11B, IL12B, MMP1, MMP9, BIRC3
31atorvastatin45 50 29 11 2414.4SELP, MMP9, MMP1, PON1, TNFRSF11B, GNB3
32ly2940024510.4SELP, BIRC3, MMP9, IL12B, TNFRSF11B
33norepinephrine45 11 2412.4MMP1, GNB3
34serine4510.4TNFRSF11B, F7, MMP1, MMP9, BIRC3
35cholesterol45 29 11 2413.3GNB3, TNFRSF11B, FABP2, PON1, F7, SELP
36testosterone45 60 11 2413.3TNFRSF11B, AKR1D1, PON1, PGRMC1, MMP1, MMP9
37sele4510.3PON1, SELP
38vitamin-e4510.3PON1, F7, BIRC3
39creatinine4510.3TNFRSF11B, FABP2, PON1, F7, MMP1, MMP9
40fibrinogen4510.3TNFRSF11B, HABP2, DUSP2, PON1, F7, MMP9
41homocysteine45 2411.2SELP, PON1, TNFRSF11B
42(4-aminophenyl)mercuric acetate4510.2MMP1, MMP9
43cysteine4510.1TNFRSF11B, FABP2, PON1, MMP1, MMP9, SELP
44lipid4510.1GNB3, TNFRSF11B, FABP2, PON1, F7, IL12B
45calcium45 50 11 2413.0TNFRSF11B, HABP2, DUSP2, F7, PGRMC1, IL12B
46sp 60012545 6010.9BIRC3, MMP9, MMP1

GO Terms for genes affiliated with Carotid Stenosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.3IL12A, IL12B
2extracellular spaceGO:0056159.2SELP, TNFRSF11B, HABP2, MEP1A, PON1, F7

Biological processes related to Carotid Stenosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.5IL12A, IL12B
2positive regulation of NK T cell activationGO:05113510.5IL12A, IL12B
3positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.5IL12A, IL12B
4positive regulation of lymphocyte proliferationGO:05067110.4IL12A, IL12B
5positive regulation of smooth muscle cell apoptotic processGO:03439310.4IL12B, IL12A
6positive regulation of natural killer cell activationGO:03281610.4IL12B, IL12A
7digestionGO:00758610.3FABP2, MEP1A, AKR1D1
8defense response to protozoanGO:04283210.3IL12A, IL12B
9negative regulation of interleukin-17 productionGO:03270010.2IL12A, IL12B
10proteolysisGO:00650810.0HABP2, MEP1A, F7, MMP1, MMP9
11response to UV-BGO:01022410.0IL12A, IL12B

Molecular functions related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.2MMP9, MMP1, MEP1A
2interleukin-12 receptor bindingGO:00514310.0IL12A, IL12B

Products for genes affiliated with Carotid Stenosis

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  • Antibodies

Sources for Carotid Stenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet