MCID: CRT013
MIFTS: 49

Carotid Stenosis malady

Cardiovascular diseases category
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Summaries for Carotid Stenosis

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Wikipedia:65 Carotid stenosis is a narrowing or constriction of the inner surface (lumen) of the carotid artery,... more...

MalaCards based summary: Carotid Stenosis, also known as carotid artery stenosis, is related to hepatitis and abdominal aortic aneurysm. An important gene associated with Carotid Stenosis is HABP2 (hyaluronan binding protein 2), and among its related pathways are IL-3 Signaling Pathway and amb2 Integrin signaling. The compounds sele and lxa4 have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Carotid Stenosis

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Carotid Stenosis, Aliases & Descriptions:

Name: Carotid Stenosis 8 46 10 44 62
Carotid Artery Stenosis 8 62
 
Carotid Stenosis, Susceptibility to 9
Stenosis, Carotid Artery 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:13001
SNOMED-CT57 195181000, 64586002
MeSH34 D016893

Related Diseases for Carotid Stenosis

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Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.8PON1, SELP
2abdominal aortic aneurysm30.7MMP1, MMP9
3ischemia30.7SELP, PON1, FABP2
4vascular disease30.4SELP, PON1, MMP9
5thromboembolism30.4HABP2, SELP
6hyperhomocysteinemia30.4PON1, SELP
7proliferative diabetic retinopathy30.3SELP, MMP9
8hypercholesterolemia30.1FABP2, PON1, SELP
9cerebrovascular disease30.1SELP, PON1, FABP2
10breast cancer29.8MMP1, MMP9, HABP2
11atherosclerosis29.1HABP2, SELP, PON1, MMP9, MMP1, FABP2
12cerebritis10.8
13cervicitis10.5
14artery disease10.4
15intracranial aneurysm10.4
16aneurysm10.4
17arteriosclerosis10.4PON1
18retinitis10.3
19aortic aneurysm10.3
20synovitis10.3MMP1
21peripheral vascular disease10.3
22coronary stenosis10.3PON1, SELP
23antiphospholipid syndrome10.2PON1, SELP
24familial combined hyperlipidemia10.2FABP2, PON1
25hypertension10.2
26neuronitis10.2
27carotid artery disease10.2
28retinal artery occlusion10.2
29sleep apnea10.2
30autonomic dysfunction10.2
31blindness10.2
32sinusitis10.2
33pituitary apoplexy10.2
34aortitis10.2
35tetralogy of fallot10.2
36moyamoya disease10.2
37subclavian steal syndrome10.2
38oral squamous cell carcinoma10.2
39tracheal stenosis10.2
40brain stem infarction10.2
41hepatic encephalopathy10.2
42kidney disease10.2
43mediastinitis10.2
44williams syndrome10.2
45familial hyperlipidemia10.2PON1, SELP
46glucose intolerance10.2FABP2, PON1
47hypertriglyceridemia10.1FABP2, PON1
48conjunctivochalasis10.1MMP9, MMP1
49middle ear cholesteatoma10.1MMP1, MMP9
50pulmonary emphysema10.1MMP1, MMP9

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to carotid stenosis

Symptoms for Carotid Stenosis

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Drugs & Therapeutics for Carotid Stenosis

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Drug clinical trials:

Search ClinicalTrials for Carotid Stenosis

Search NIH Clinical Center for Carotid Stenosis

Genetic Tests for Carotid Stenosis

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Anatomical Context for Carotid Stenosis

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MalaCards organs/tissues related to Carotid Stenosis:

32
Brain, Heart, Bone, Smooth muscle, Breast, T cells, Endothelial

Animal Models for Carotid Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Carotid Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.1IL12A, FABP2, MMP1, MMP9, PON1, SELP

Publications for Carotid Stenosis

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Articles related to Carotid Stenosis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Endovascular advances for extracranial carotid stenosis. (24402498)
2014
2
Long-term follow-up study of endarterectomy versus angioplasty in patients with symptomatic severe carotid stenosis trial. (25082808)
2014
3
Safety and effectiveness of emergency carotid artery stenting for a high-grade carotid stenosis with intraluminal thrombus under proximal flow control in hyperacute and acute stroke. (22170821)
2013
4
Treatment of symptomatic carotid stenosis: carotid stent placement versus endarterectomy. (23873312)
2013
5
Reversal of ophthalmic artery flow and stroke outcomes in asian patients with acute ischemic stroke and unilateral severe cervical carotid stenosis. (24312492)
2013
6
Quantitative flow measurement by digital subtraction angiography in cerebral carotid stenosis using optical flow method. (23694912)
2013
7
A randomized trial of decision-making in asymptomatic carotid stenosis. (22218277)
2012
8
Secondary stroke prevention: patent foramen ovale, aortic plaque, and carotid stenosis. (22422912)
2012
9
Identifying high-risk asymptomatic carotid stenosis. (23480656)
2012
10
Carotid stenosis treatments compared. Both surgical and nonsurgical options can prevent stroke. (23437463)
2012
11
Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. (22935402)
2012
12
Circulating lipoprotein-associated phospholipase A2 in high-grade carotid stenosis: a new biomarker for predicting unstable plaque. (22075154)
2012
13
Higher incidence of carotid stenosis in patients with central retinal artery occlusion. (20384592)
2011
14
Controversies in neurology: asymptomatic carotid stenosis--intervention or just stick to medical therapy. The argument for carotid endarterectomy. (21298296)
2011
15
Update on surgical management for asymptomatic carotid stenosis. (20922504)
2011
16
Asymptomatic carotid stenosis: screening and management. (21667597)
2011
17
Treatment strategies for carotid stenosis in patients at increased risk for surgery. (21722783)
2011
18
Short-term outcome after stenting versus endarterectomy for symptomatic carotid stenosis: a preplanned meta-analysis of individual patient data. (20832852)
2010
19
Inraoperative and Histological Visualization of Disrupted Vulnerable Plaques following Diagnostic Angiography of Moderate Carotid Stenosis. (20700419)
2010
20
Cerebral reserve is decreased in elderly patients with carotid stenosis. (20620003)
2010
21
Extracranial carotid stenosis and peripheral arterial disease in Thai patients with coronary artery disease. (20483809)
2010
22
Reproducibility of semi-automated measurement of carotid stenosis on CTA. (20724259)
2010
23
Stroke: Carotid stenosis--surgery or stenting to prevent stroke? (21131910)
2010
24
How should physicians practically approach symptomatic and asymptomatic carotid stenosis? (20726212)
2010
25
Cardiac surgery, carotid stenosis, and stroke prevention. (20469611)
2010
26
Central sleep apnea indicates autonomic dysfunction in asymptomatic carotid stenosis: a potential marker of cerebrovascular and cardiovascular risk. (20337190)
2010
27
Carotid wall thickness and stroke risk in patients with asymptomatic internal carotid stenosis. (20079904)
2010
28
Two cases of branch retinal arterial occlusion after carotid artery stenting in the carotid stenosis. (19337482)
2009
29
Prevalence of carotid stenosis in a high-risk Caribbean population. (19246696)
2009
30
Strokes after cardiac surgery and relationship to carotid stenosis. (19752298)
2009
31
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis. (19416961)
2009
32
High risk of early neurological recurrence in symptomatic carotid stenosis. (19498196)
2009
33
High cardiovascular event rates in patients with asymptomatic carotid stenosis: the REACH Registry. (19473362)
2009
34
Does metabolic syndrome predict silent carotid stenosis in coronary patients? (18283528)
2008
35
Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. (19012726)
2008
36
Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial. (18774745)
2008
37
Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting. (18486427)
2008
38
How asymptomatic is asymptomatic carotid stenosis? (17581914)
2007
39
Current status of carotid endarterectomy and stenting for symptomatic carotid stenosis. (17971647)
2007
40
Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from the ACSRS study. Nicolaides et al.: EJVES 2005; 30: 275-284. (16359888)
2006
41
Accuracy of angiography and Doppler ultrasonography in the detection of carotid stenosis: a histopathological study of 123 cases. (16523222)
2006
42
Accurate, practical and cost-effective assessment of carotid stenosis in the UK. (16904049)
2006
43
Atherosclerotic carotid stenosis and occlusion. (17290125)
2006
44
Recurrent carotid stenosis after angioplasty and stenting. (15874940)
2005
45
Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Results from the helsinki carotid endarterectomy study. (15775709)
2005
46
Commentary. Carotid angioplasty and stenting versus carotid endarterectomy for treatment of asymptomatic carotid stenosis: a randomized trial in a community hospital. (15952703)
2005
47
Carotid stenosis measurement on colour Doppler ultrasound: agreement of ECST, NASCET and CCA methods applied to ultrasound with intra-arterial angiographic stenosis measurement. (15964165)
2005
48
Adhesion molecule expression in symptomatic and asymptomatic carotid stenosis. (12821729)
2003
49
An angiotensin-converting enzyme gene polymorphism suggests a genetic distinction between ischaemic stroke and carotid stenosis. (10354208)
1999
50
Cerebral ischemia in a patient with protein S deficiency and carotid stenosis. (8056555)
1994

Variations for Carotid Stenosis

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Expression for genes affiliated with Carotid Stenosis

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Expression patterns in normal tissues for genes affiliated with Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for genes affiliated with Carotid Stenosis

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Compounds for genes affiliated with Carotid Stenosis

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Compounds related to Carotid Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1sele4410.0SELP, PON1
2lxa4449.9MMP1, SELP
3clopidogrel44 50 24 1112.8PON1, SELP
4cgs-27023a449.8MMP1, MMP9
5prinomastat449.8MMP9, MMP1
6ilomastat449.8MMP1, MMP9
7latanoprost44 1110.7MMP1, MMP9
88-isoprostane449.7PON1, MMP9
9candesartan44 50 28 1112.7SELP, MMP1
10cilomilast449.7MMP1, MMP9
11(4-aminophenyl)mercuric acetate449.7MMP9, MMP1
12quinacrine44 1110.7MMP1, SELP
13gm 6001619.7MMP1, MMP9
14gi 254023x619.7MMP1, MMP9
15uk 383367619.7MMP1, MMP9
16geranylgeranyl pyrophosphate449.7MMP1, MMP9
17hydroxamate449.6MMP1, MMP9
18marimastat44 61 1111.6MMP9, MMP1
19zoledronic acid449.6MMP9, MMP1
201,10-phenanthroline44 210.6MMP1, MMP9
21ns 39844 6110.5MMP1, MMP9
22simvastatin44 50 61 28 24 1114.5SELP, PON1, MMP9
23batimastat44 61 1111.4MMP1, MMP9
24pravastatin44 50 28 24 1113.4MMP1, PON1, SELP
25dextran sulfate449.4SELP, HABP2
26aspirin44 50 28 2412.4MMP1, PON1, SELP
27hyaluronic acid44 2410.4MMP1, MMP9, HABP2
28aprotinin44 1110.4MMP1, MMP9, SELP
29hydroxyproline44 24 1111.3MMP1, MMP9
30formaldehyde44 2410.3MMP1, MMP9, SELP
31alpha tocopherol449.3MMP1, MMP9, PON1
32rantes449.3MMP1, MMP9, SELP
33epinephrine44 24 1111.3SELP, MMP9, MMP1
34rosiglitazone28 44 50 24 1113.3PON1, MMP9, MMP1
35n acetylcysteine449.3SELP, MMP9, MMP1
36norepinephrine44 24 1111.2MMP1, MMP9, SELP
37fibrinogen449.2MMP9, PON1, SELP, HABP2
38genistein44 28 61 2 24 1114.1SELP, MMP9, MMP1
39mycophenolate mofetil44 50 1111.1SELP, MMP1, IL12A
40fenofibrate44 50 1111.0FABP2, MMP9, PON1, SELP
41cyclosporin a44 28 6111.0MMP1, MMP9, SELP
42pge2448.9SELP, MMP9, MMP1
43fluvastatin44 50 28 1111.9SELP, PON1, MMP9, MMP1
44atorvastatin44 50 28 24 1112.9MMP1, MMP9, PON1, SELP
45lactate448.8MMP1, MMP9, SELP
46vitamin a44 24 1110.8FABP2, MMP1, MMP9, PON1
47estrogen448.8MMP1, MMP9, PON1, SELP
48retinoic acid44 249.7SELP, MMP9, MMP1, FABP2
49creatinine448.4SELP, PON1, MMP9, MMP1, FABP2
50cysteine448.4SELP, PON1, MMP9, MMP1, FABP2

GO Terms for genes affiliated with Carotid Stenosis

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Cellular components related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5MMP1, MMP9, PON1, HABP2
2extracellular spaceGO:0056157.6IL12A, MMP9, PON1, SELP, HABP2

Biological processes related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2IL12A, SELP
2collagen catabolic processGO:0305749.2MMP1, MMP9
3extracellular matrix disassemblyGO:0226179.0MMP1, MMP9
4leukocyte migrationGO:0509008.9MMP1, MMP9, SELP

Molecular functions related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.3MMP1, MMP9

Products for genes affiliated with Carotid Stenosis

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  • Antibodies
  • Proteins
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Sources for Carotid Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet