MCID: CRT013
MIFTS: 51

Carotid Stenosis malady

Summaries for Carotid Stenosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Carotid stenosis is a narrowing or constriction of the inner surface (lumen) of the carotid artery,... more...

MalaCards: Carotid Stenosis, also known as carotid stenosis, susceptibility to, is related to stroke, ischemic and ischemia. An important gene associated with Carotid Stenosis is HABP2 (hyaluronan binding protein 2), and among its related pathways are Syndecan-1-mediated signaling events and Immune response IL-12 signaling pathway. The compounds rantes and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related mouse phenotype immune system.

Aliases & Classifications for Carotid Stenosis

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 9diseasecard, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

carotid stenosis 8 46 10 44 60
carotid stenosis, susceptibility to 9
stenosis, carotid artery 8
carotid artery stenosis 8


External Ids:

Disease Ontology8 DOID:13001
SNOMED-CT56 195181000, 64586002
MeSH34 D016893

Related Diseases for Carotid Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Carotid Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1stroke, ischemic30.8MMP9, F7
2ischemia30.6TNFRSF11B, FABP2, PON1, SELP
3abdominal aortic aneurysm30.4TNFRSF11B, MMP1, MMP9
4vascular disease30.3SELP
5coronary artery disease30.3GNB3, TNFRSF11B, PON1, F7, MMP9, SELP
6hypertension30.2GNB3, MMP9
7hepatitis c30.2IL12B, PON1
8diabetic retinopathy29.9PON1
9cerebrovascular disease29.9SELP, PON1, FABP2
10hyperhomocysteinemia29.9SELP, PON1
11breast cancer29.9TNFRSF11B, PON1, PGRMC1, MMP1, MMP9, BIRC3
12ischemic heart disease29.9SELP, F7, PON1
13atherosclerosis29.9GNB3, TNFRSF11B, FABP2, HABP2, PON1, F7
14cerebritis10.8
15coronary stenosis10.6
16cervicitis10.5
17intracranial aneurysm10.3
18carotid artery occlusion10.3
19carotid artery disease10.3
20retinitis10.3
21aortic aneurysm10.3
22hepatitis10.3
23peripheral vascular disease10.2
24cholesterol embolism10.1
25retinal artery occlusion10.1
26moyamoya disease10.1
27subclavian steal syndrome10.1
28tracheal stenosis10.1
29pituitary apoplexy10.1
30aortitis10.1
31tetralogy of fallot10.1
32hepatitis a10.1
33brain stem infarction10.1
34cerebral arterial disease10.1
35hepatic encephalopathy10.1
36kidney disease10.1
37mediastinitis10.1
38squamous cell carcinoma10.1
39polycystic ovary syndrome10.0PON1
40galactosemia10.0F7
41lung cancer10.0MMP9
42kawasaki disease10.0MMP9
43multiple myeloma10.0TNFRSF11B
44infertility10.0PON1
45peritonitis10.0SELP
46malaria10.0IL12B
47pancreatitis10.0SELP
48pulmonary disease, chronic obstructive10.0MMP9
49psoriasis10.0SELP, IL12B
50primary hyperoxaluria10.0TNFRSF11B, SELP

Graphical network of the top 20 diseases related to Carotid Stenosis:



Diseases related to carotid stenosis

Clinical Features for Carotid Stenosis

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Drugs & Therapeutics for Carotid Stenosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Carotid Stenosis

Drug clinical trials:

Search ClinicalTrials for Carotid Stenosis

Search NIH Clinical Center for Carotid Stenosis

Search CenterWatch for Carotid Stenosis

Genetic Tests for Carotid Stenosis

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Anatomical Context for Carotid Stenosis

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32MalaCards
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MalaCards organs/tissues related to Carotid Stenosis:

32
Brain, Heart, Endothelial, Bone, Smooth muscle, Kidney, Breast, T cells, Pituitary

Animal Models for Carotid Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Carotid Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.5SELP, BIRC3, MMP9, IL12A, IL12B, DUSP2

Publications for Carotid Stenosis

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50PubMed
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Articles related to Carotid Stenosis:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Abnormal levels of serum anti-elastin antibodies in patients with symptomatic carotid stenosis. (24388508)
2014
2
Quantitative flow measurement by digital subtraction angiography in cerebral carotid stenosis using optical flow method. (23694912)
2013
3
Bilateral internal carotid artery stenosis complicating acute sinusitis. (23584073)
2013
4
Risk scoring system to predict 3-year survival in patients treated for asymptomatic carotid stenosis. (23548173)
2013
5
Association between asymptomatic carotid stenosis and cognitive function: a systematic review. (23727050)
2013
6
Symptomatic carotid stenosis in the setting of bilateral disease and coexisting carotid body tumor: management with a carotid stent and staged excision. (23493283)
2013
7
Inverse fly-through technique in ultrasound imaging of carotid stenosis. (23267033)
2013
8
Asymptomatic and symptomatic carotid stenosis: an obsolete classification? (22315705)
2012
9
Silent stroke and cognitive decline in asymptomatic carotid stenosis revascularization. (22734086)
2012
10
Ischemic postconditioning alleviates neuronal injury caused by relief of carotid stenosis in a rat model of cerebral hypoperfusion. (23202956)
2012
11
Carotid stenosis after adjuvant cervical radiotherapy in patients with head and neck cancers: a prospective controlled study. (22943608)
2012
12
Carotid stenosis: to revascularize, or not to revascularize: that is the question. (21849648)
2011
13
Protein S-100B as biochemical marker of brain ischemic damage after treatment of carotid stenosis. (21620650)
2011
14
Revascularization of asymptomatic high-grade carotid stenosis is still indicated in some cases. (21393585)
2011
15
Patient preference survey in the management of asymptomatic carotid stenosis. (21477967)
2011
16
Biomarkers of asymptomatic carotid stenosis in patients undergoing coronary artery bypass grafting. (21233473)
2011
17
Is endovascular stent therapy or endarterectomy more effective for the treatment of symptomatic and asymptomatic carotid stenosis? (20882370)
2011
18
Short-term outcome after stenting versus endarterectomy for symptomatic carotid stenosis: a preplanned meta-analysis of individual patient data. (20832852)
2010
19
Three-dimensional volumetric analysis of atherosclerotic plaques: a magnetic resonance imaging-based study of patients with moderate stenosis carotid artery disease. (20532633)
2010
20
How should physicians practically approach symptomatic and asymptomatic carotid stenosis? (20726212)
2010
21
Has surgery won the race against endovascular treatment for carotid stenosis? (20189460)
2010
22
An updated review of current concepts in the management of carotid stenosis. (21289864)
2010
23
Recommendations for the management of patients with carotid stenosis. (20635593)
2010
24
Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: a prospective, population-based study. (19926843)
2010
25
Case study of Tc-99m HMPAO brain SPECT imaging in a patient with hepatic encephalopathy and carotid artery stenosis. (20395702)
2010
26
Carotid artery stenting versus endarterectomy for carotid stenosis. (20674713)
2010
27
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis. (19416961)
2009
28
High risk of early neurological recurrence in symptomatic carotid stenosis. (19498196)
2009
29
Flow reversal for proximal neuroprotection during endovascular management of critical symptomatic carotid artery stenosis coexisting with ipsilateral external carotid artery occlusion. (19995121)
2009
30
Temporal approach: a good way to provide cerebral protection for proximal carotid stenosis, the last chance for trackability in CAS. (19329915)
2009
31
Prevalence of carotid stenosis and silent myocardial ischemia in asymptomatic subjects with a low ankle-brachial index. (18829225)
2009
32
Aging and total stenosis triggers differential responses of carotid and basilar arteries to endothelin-1 and phenylephrine. (20093799)
2009
33
Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial. (19106795)
2009
34
Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. (19012726)
2008
35
Revascularization of carotid stenosis before cardiac surgery. (19018692)
2008
36
Angioplasty and stenting of asymptomatic carotid stenosis before cardiac surgery: more study is needed. (19064761)
2008
37
C-reactive protein predicts future cardiovascular events in patients with carotid stenosis. (17322087)
2007
38
Acceleation of cerebrovascular reactivity as a new supplemental TCD index in patients with severe carotid stenosis before and after carotid endarterectomy. (17535573)
2007
39
What should we do with asymptomatic carotid stenosis? (18705984)
2007
40
Impaired cerebral autoregulation distal to carotid stenosis/occlusion is associated with increased risk of stroke at cardiac surgery with cardiopulmonary bypass. (17723819)
2007
41
Risk factor analysis for development of asymptomatic carotid stenosis in Koreans. (16479058)
2006
42
Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. (17050890)
2006
43
The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial. (16514091)
2006
44
High-grade symptomatic and asymptomatic carotid stenosis in the very elderly. A challenge for proponents of carotid angioplasty and stenting. (16573829)
2006
45
Cerebral vasomotor reactivity of bilateral severe carotid stenosis: is stroke unavoidable? (16490050)
2006
46
Recurrent carotid stenosis after angioplasty and stenting. (15874940)
2005
47
Renal cholesterol embolism in patients with carotid stenosis: a severe and underdiagnosed complication following cerebrovascular procedures. (15240205)
2004
48
Use of orbital color Doppler imaging for detecting internal carotid artery stenosis in patients with amaurosis fugax. (12782164)
2003
49
Ipsilateral proliferative diabetic retinopathy in carotid stenosis. (11318273)
2001
50
The significance of cerebral infarction and atrophy in patients with amaurosis fugax and transient ischemic attacks in relation to internal carotid artery stenosis: a preliminary report. (3339768)
1988

Genetic Variations for Carotid Stenosis

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Expression for genes affiliated with Carotid Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carotid Stenosis

Search GEO for disease gene expression data for Carotid Stenosis.

Pathways for genes affiliated with Carotid Stenosis

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37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Pathways related to Carotid Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3MMP9, MMP1
210.2SELP, IL12A, IL12B
3
Hide members
10.0BIRC3, IL12A, IL12B, TNFRSF11B

Compounds for genes affiliated with Carotid Stenosis

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Carotid Stenosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1rantes4410.8IL12B
2pge24410.8MMP9
3cgs-27023a4410.7MMP1, MMP9
4mdmp4410.7SELP, DUSP2
5prinomastat4410.7MMP9, MMP1
6ilomastat4410.6MMP9, MMP1
7geranylgeranyl pyrophosphate4410.6MMP9, MMP1, TNFRSF11B
8zoledronic acid4410.6MMP9, MMP1, TNFRSF11B
9mycophenolate mofetil44 49 1112.6SELP, MMP1, IL12A
10ns 39844 5911.6TNFRSF11B, MMP1, MMP9
11epinephrine44 11 2412.6SELP, GNB3
12pdmp4410.6DUSP2, SELP
13fenofibrate44 49 1112.6SELP, MMP9, PON1, FABP2
14nitroglycerin44 1111.6SELP, TNFRSF11B, GNB3
15latanoprost44 1111.6MMP1, MMP9
16pravastatin44 49 28 11 2414.6SELP, MMP1, PON1, GNB3
17lxa44410.6MMP1, SELP
18kininogen4410.5HABP2, F7, SELP
19hydroxyproline44 11 2412.5MMP9, MMP1, TNFRSF11B
20pentoxifylline44 1111.5SELP, MMP1, IL12B
21simvastatin44 49 59 28 11 2415.5GNB3, PON1, MMP9, SELP
22cilomilast4410.5MMP1, MMP9
23aprotinin44 1111.5SELP, MMP1
24vitamin a44 11 2412.5FABP2, PON1, MMP1, MMP9
25fluvastatin44 49 28 1113.5GNB3, PON1, MMP1, MMP9, SELP
26celecoxib44 59 28 49 11 2415.5MMP9, MMP1, TNFRSF11B
27glucose4410.5SERPINA12
28pdtc4410.4MMP1, MMP9, BIRC3
29aspirin44 49 28 2413.4TNFRSF11B, DUSP2, PON1, MMP1, SELP
30sb 20358044 5911.4TNFRSF11B, IL12B, MMP1, MMP9, BIRC3
31atorvastatin44 49 28 11 2414.4SELP, MMP9, MMP1, PON1, TNFRSF11B, GNB3
32ly2940024410.4SELP, BIRC3, MMP9, IL12B, TNFRSF11B
33norepinephrine44 11 2412.4MMP1, GNB3
34serine4410.4TNFRSF11B, F7, MMP1, MMP9, BIRC3
35cholesterol44 28 11 2413.3GNB3, TNFRSF11B, FABP2, PON1, F7, SELP
36testosterone44 59 11 2413.3TNFRSF11B, AKR1D1, PON1, PGRMC1, MMP1, MMP9
37sele4410.3PON1, SELP
38vitamin-e4410.3PON1, F7, BIRC3
39creatinine4410.3TNFRSF11B, FABP2, PON1, F7, MMP1, MMP9
40fibrinogen4410.3TNFRSF11B, HABP2, DUSP2, PON1, F7, MMP9
41homocysteine44 2411.2SELP, PON1, TNFRSF11B
42(4-aminophenyl)mercuric acetate4410.2MMP1, MMP9
43cysteine4410.1TNFRSF11B, FABP2, PON1, MMP1, MMP9, SELP
44lipid4410.1GNB3, TNFRSF11B, FABP2, PON1, F7, IL12B
45calcium44 49 11 2413.0TNFRSF11B, HABP2, DUSP2, F7, PGRMC1, IL12B
46sp 60012544 5910.9BIRC3, MMP9, MMP1

GO Terms for genes affiliated with Carotid Stenosis

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16Gene Ontology
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Cellular components related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.3IL12A, IL12B
2extracellular spaceGO:0056159.2SELP, TNFRSF11B, HABP2, MEP1A, PON1, F7

Biological processes related to Carotid Stenosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.5IL12A, IL12B
2positive regulation of NK T cell activationGO:05113510.5IL12A, IL12B
3positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.5IL12A, IL12B
4positive regulation of lymphocyte proliferationGO:05067110.4IL12A, IL12B
5positive regulation of smooth muscle cell apoptotic processGO:03439310.4IL12B, IL12A
6positive regulation of natural killer cell activationGO:03281610.4IL12B, IL12A
7digestionGO:00758610.3FABP2, MEP1A, AKR1D1
8defense response to protozoanGO:04283210.3IL12A, IL12B
9negative regulation of interleukin-17 productionGO:03270010.2IL12A, IL12B
10proteolysisGO:00650810.0HABP2, MEP1A, F7, MMP1, MMP9
11response to UV-BGO:01022410.0IL12A, IL12B

Molecular functions related to Carotid Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.2MMP9, MMP1, MEP1A
2interleukin-12 receptor bindingGO:00514310.0IL12A, IL12B

Products for genes affiliated with Carotid Stenosis

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Sources for Carotid Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet