MCID: CRP001
MIFTS: 53

Carpal Tunnel Syndrome malady

Neuronal category

Summaries for Carpal Tunnel Syndrome

Sources:
34MedlinePlus, 3CDC, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. suddenly, a sharp, piercing pain shoots through the wrist and up your arm. just a passing cramp? it could be carpal tunnel syndrome. the carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. it contains nerve and tendons. sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. symptoms usually start gradually. as they worsen, grasping objects can become difficult. often, the cause is having a smaller carpal tunnel than other people do. other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. women are three times more likely to have carpal tunnel syndrome than men. early diagnosis and treatment are important to prevent permanent nerve damage. your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. nih: national institute of neurological disorders and stroke

MalaCards: Carpal Tunnel Syndrome, also known as carpal tunnel median neuropathy, is related to amyloidosis and arthritis. An important gene associated with Carpal Tunnel Syndrome is TTR (transthyretin), and among its related pathways are Cell adhesion ECM remodeling and Cell adhesion Cell-matrix glycoconjugates. The compounds cycloheximide and glutamate have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and kidney.

CDC:3 Ergonomics is the scientific study of people at work. The goal of ergonomics is to reduce stress and eliminate injuries and disorders associated with the overuse of muscles, bad posture, and repeated tasks. This is accomplished by designing tasks, work spaces, controls, displays, tools, lighting, and equipment to fit the employee´s physical capabilities and limitations.

NINDS:44

Wikipedia:64 Carpal tunnel syndrome (CTS) is a median entrapment neuropathy that causes paresthesia, pain, numbness,... more...

Description from OMIM:47 115430

Aliases & Classifications for Carpal Tunnel Syndrome

Sources:
8Disease Ontology, 22GTR, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 47OMIM, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

carpal tunnel syndrome 8 22 44 10 45 34 61
carpal tunnel median neuropathy 8
cts - carpal tunnel syndrome 8
median nerve entrapment 8


External Ids:

Disease Ontology8 DOID:12169
OMIM47 115430
ICD9CM27 354.0
NCIt40 C34450
MeSH35 D002349
ICD1025 G56.0

Related Diseases for Carpal Tunnel Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Carpal Tunnel Syndrome family:

carpal tunnel syndrome, familial

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.9TTR, B2M, APCS
2arthritis30.7ADCYAP1, TAC1, B2M, ITGA4, CCL3
3arthropathy30.2B2M, TAC1
4arteriosclerosis30.2TGIF1, ELN
5vascular disease30.2ADCYAP1, ELN
6osteoarthritis30.2TAC1, CCL3
7n syndrome11.2
8carpal tunnel syndrome, familial10.7
9thoracic outlet syndrome10.6
10ulnar neuropathy10.6
11diabetic polyneuropathy10.5
12pseudogout10.5
13median neuropathy10.5
14conn's syndrome10.5
15micro syndrome10.5
16char syndrome10.5
17mass syndrome10.5
18gout10.5
19transthyretin amyloidosis10.5
20bod syndrome10.5
21radiculopathy10.4
22mucolipidosis10.4
23acromegaly10.4
24adult syndrome10.4
25synovitis10.4
26macroglossia10.4
27eosinophilic fasciitis10.4
28mycobacterium kansasii10.4
29autonomic dysfunction10.4
30chronic pain10.4
31pigmented villonodular synovitis10.3
32villonodular synovitis10.3
33epicondylitis10.3
34intraneural perineurioma10.3
35tuberculosis10.3
36amyloid neuropathy10.3
37chronic inflammatory demyelinating polyneuropathy10.3
38hansen's disease10.3
39image syndrome10.3
40cumulative trauma disorders10.3
41paresthesia10.3
42senile systemic amyloidosis10.3
43tendinitis10.2
44neurofibromatosis10.2
45pulmonary tuberculosis10.2
46periarthritis10.2
47nodular tenosynovitis10.2
48tendon sheath lipoma10.2
49cutaneous lupus erythematosus10.2
50tarsal tunnel syndrome10.2

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to carpal tunnel syndrome

Clinical Features for Carpal Tunnel Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

115430

Drugs & Therapeutics for Carpal Tunnel Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Carpal Tunnel Syndrome

Drug clinical trials:

Search ClinicalTrials for Carpal Tunnel Syndrome

Search NIH Clinical Center for Carpal Tunnel Syndrome

Search CenterWatch for Carpal Tunnel Syndrome

Genetic Tests for Carpal Tunnel Syndrome

Sources:
22GTR
See all sources

Genetic tests related to Carpal Tunnel Syndrome:

id Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome22

Anatomical Context for Carpal Tunnel Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Carpal Tunnel Syndrome:

33
Skin, Brain, Kidney, Whole blood, Breast, B cells

Animal Models for Carpal Tunnel Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Carpal Tunnel Syndrome

Sources:
51PubMed
See all sources

Articles related to Carpal Tunnel Syndrome:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
Comparative analysis between minimal access versus traditional accesses in carpal tunnel syndrome: A perspective randomised study. (24290977)
2014
2
Local injection versus surgery in carpal tunnel syndrome: Neurophysiologic outcomes of a randomized clinical trial. (24321619)
2013
3
Reply.Re: Zyluk A. and Szlosser Z. The results of carpal tunnel release for carpal tunnel syndrome diagnosed on clinical grounds, with or without electrophysiological investigations: a randomized study. J Hand Surg Eur. 2013, 38: 44a899. (23940845)
2013
4
Collagenoma in a child with tuberous sclerosis complex causing carpal tunnel syndrome and thumb overgrowth: case report. (24011722)
2013
5
The relationship of median nerve F-wave parameters with severity and subtypes of carpal tunnel syndrome. (23948836)
2013
6
Role of anthropometric characteristics in idiopathic carpal tunnel syndrome. (23178273)
2013
7
Is carpal tunnel syndrome a slow, chronic, progressive nerve entrapment? (24119462)
2013
8
Second lumbrical and mixed nerve segmental conduction studies in carpal tunnel syndrome. (23703011)
2013
9
The effect of carpal tunnel syndrome on grip and pinch strength compared to gender and age matched normative data. (23982986)
2013
10
Early versus delayed endoscopic surgery for carpal tunnel syndrome: prospective randomized study. (23022645)
2013
11
Neurological picture. Unilateral carpal tunnel syndrome secondary to lipomatosis of the median nerve. (23138767)
2013
12
Carpal tunnel syndrome - an occupational hazard facing dentistry. (24074016)
2013
13
Staged release of bilateral carpal tunnel syndrome: cancellation rates of the second side procedure. (23172822)
2013
14
Is the combined sensory (Robinson) index routinely indicated for all cases of suspected carpal tunnel syndrome undergoing electrodiagnostic evaluation? (23701980)
2013
15
Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology. (23799199)
2013
16
Comparison of proximal and distal cross-sectional areas of the median nerve, carpal tunnel, and nerve/tunnel index in subjects with carpal tunnel syndrome. (23727345)
2013
17
Comparison of surgical decompression and local steroid injection in the treatment of carpal tunnel syndrome: 2-year clinical results from a randomized trial. (22467087)
2012
18
Hand-held nerve conduction device in carpal tunnel syndrome: a prospective study. (22499088)
2012
19
Effects of carpal tunnel syndrome on adaptation of multi-digit forces to object mass distribution for whole-hand manipulation. (23171737)
2012
20
Carpal tunnel syndrome in pregnancy. (23026467)
2012
21
Characteristics of sleep disturbance in patients with carpal tunnel syndrome. (23449036)
2012
22
Bifid median nerve in a patient with carpal tunnel syndrome--correlation of clinical, diagnostic and intraoperative findings: case report and review of the literature. (23540177)
2012
23
Carpal tunnel syndrome after distal radius fracture. (23026468)
2012
24
The electrodiagnostic approach to carpal tunnel syndrome. (22361370)
2012
25
Ultrasonographic assessment of carpal tunnel syndrome of mild and moderate severity in diabetic patients by using an 8-point measurement of median nerve cross-sectional areas. (22768921)
2012
26
Color Doppler ultrasound for evaluation of vasomotor activity in patients with carpal tunnel syndrome. (21479858)
2012
27
Carpal tunnel syndrome: symptoms, diagnosis, and treatment options. (22991883)
2012
28
Effectiveness of low-level laser therapy for patients with carpal tunnel syndrome: design of a randomized single-blinded controlled trial. (23237204)
2012
29
Carpal tunnel syndrome. (22585195)
2012
30
Triamcinolone acetonide vs procaine hydrochloride injection in the management of carpal tunnel syndrome: randomized placebo-controlled study. (22674243)
2012
31
Surgical options for recalcitrant carpal tunnel syndrome with perineural fibrosis. (23450185)
2012
32
Recurrent blistering of the fingertips as a sign of carpal tunnel syndrome: an effect of nerve compression. (22508886)
2012
33
The comparative effectiveness of combined lumbrical muscle splints and stretches on symptoms and function in carpal tunnel syndrome. (22200381)
2012
34
Effects of carpal tunnel syndrome on adaptation of multi-digit forces to object texture. (22627019)
2012
35
The association of Raynaud's syndrome with carpal tunnel syndrome: a meta-analysis. (21898061)
2012
36
Combination of high-resolution and color Doppler ultrasound in diagnosis of carpal tunnel syndrome. (21498348)
2011
37
Validity and reliability of the Purdue Pegboard Test in carpal tunnel syndrome. (21254080)
2011
38
Performance on a manual tracking task differentiates individuals at risk of developing carpal tunnel syndrome from those not at risk. (22014413)
2011
39
Screening for carpal tunnel syndrome using sonography. (22124001)
2011
40
Giant lipoma: an unusual cause of carpal tunnel syndrome. (22355434)
2011
41
Color and power Doppler US for diagnosing carpal tunnel syndrome and determining its severity: a quantitative image processing method. (21900619)
2011
42
Predicting intentions to use research evidence for carpal tunnel syndrome treatment decisions among certified hand therapists. (21461786)
2011
43
Vibrometry in carpal tunnel syndrome: correlations with electrodiagnositic parameters and disease severity. (21774286)
2011
44
Hand pain other than carpal tunnel syndrome (CTS): the role of occupational factors. (21663848)
2011
45
Peripheral median nerve stimulation for the treatment of iatrogenic complex regional pain syndrome (CRPS) type II after carpal tunnel surgery. (19297168)
2009
46
Electrodiagnosis as an extension of the physical examination: identifying proximal median neuropathy in the setting of carpal tunnel syndrome. (18806514)
2008
47
Pattern of paresthesia in patients with carpal tunnel syndrome. (17466582)
2007
48
The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. (15538733)
2004
49
Supracubital perineurioma misdiagnosed as carpal tunnel syndrome: case report. (15555068)
2004
50
Nodular cutaneous amyloidosis and carpal tunnel syndrome due to the amyloidogenic transthyretin His 114 variant. (11409031)
2001

Genetic Variations for Carpal Tunnel Syndrome

Expression for genes affiliated with Carpal Tunnel Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Carpal Tunnel Syndrome

Search GEO for disease gene expression data for Carpal Tunnel Syndrome.

Pathways for genes affiliated with Carpal Tunnel Syndrome

Sources:
12EMD Millipore, 54Reactome, 30KEGG
See all sources

Pathways related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cell adhesion ECM remodeling
Hide members
10.0ELN, VCAN, TNC
2
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.0TNC, VCAN, ELN
3
Hide members
9.9VCAN, TTR, ITGA4, TNC
4
Hide members
9.9TTR, B2M, MFGE8, APCS
59.7TAC1, MFGE8, APCS, CCL3
69.5APCS, PSMD9, MFGE8, B2M, TTR, VCAN
7
Hide members
9.1CCL3, TNC, PSMD9, ITGA4, RHOJ, TAC1

Compounds for genes affiliated with Carpal Tunnel Syndrome

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7ELN
2glutamate4510.7TAC1
3potassium permanganate4510.6B2M, TTR
4thioflavin t4510.5B2M, TTR
5cellulose acetate4510.5B2M, TTR, VCAN
6helospectin4510.5ADCYAP1, TAC1
7spantide4510.4ADCYAP1, TAC1
8pentosidine4510.4ELN, B2M
9calcium carbonate4510.4ELN, B2M
10guanethidine45 1111.4TAC1, ADCYAP1
11creatinine4510.4TTR, ELN, TGIF1
12neopterin4510.3CCL3, B2M, TTR
13theophylline45 29 11 2413.3B2M, TAC1, TTR, ELN
14methacholine45 1111.2TAC1, ITGA4, CCL3
15nifedipine45 50 29 1113.2ELN, ADCYAP1, TAC1, B2M
16chloride4510.2B2M, TAC1, SLC26A3, ADCYAP1
17ascorbic acid45 2411.2PMP22, TNC, TTR, ELN, TGIF1
18hyaluronic acid45 2411.2ELN, VCAN, TTR, B2M, TNC
19chondroitin sulfate45 2411.2CCL3, TNC, VCAN, ELN
20gaba4510.2ADCYAP1, TAC1, TNC, PMP22
21genistein45 29 60 2 11 2415.1ITGA4, B2M, TTR, ELN, TGIF1
22cyclophosphamide45 50 1112.1CCL3, ITGA4, B2M, TAC1
23apamin45 60 2912.1ADCYAP1, TAC1
24fmlp4510.1CCL3, ITGA4, TAC1, ADCYAP1
25vitamin d4510.1B2M, TTR, ELN, TGIF1
26heparan sulfate45 2411.1CCL3, TNC, B2M, VCAN, ELN
27epinephrine45 11 2412.1ADCYAP1, TTR, TAC1, CCL3
28tgf beta14510.1CCL3, TNC, VCAN, ELN, TGIF1
29lactate4510.0TGIF1, ELN, TTR, B2M, CCL3
30indomethacin45 60 29 1113.0ELN, ADCYAP1, TAC1, B2M, CCL3
31fibrinogen4510.0ELN, TTR, ITGA4, TNC
32glycosaminoglycan4510.0ELN, VCAN, TNC
33polysaccharide4510.0CCL3, B2M, VCAN, ELN
34serine4510.0PMP22, CCL3, ITGA4, B2M, ADCYAP1, ELN
35actinomycin d4510.0CCL3, TNC, TAC1, ADCYAP1, ELN
36aspartate459.9ELN, PMP22, ITGA4, B2M, TAC1, TTR
372,4-dinitrophenol459.9ELN, TTR
38sodium dodecylsulfate459.9TAC1, TTR, ELN
39steroid459.9PMP22, CCL3, B2M, TAC1, ADCYAP1, TGIF1
40heparin45 29 11 2412.9CCL3, ITGA4, TAC1, VCAN, ELN, TGIF1
41h2o2459.8CCL3, TNC, TAC1, ADCYAP1, ELN, TGIF1
42histamine45 29 2411.8CCL3, TAC1, ADCYAP1, ELN
43vegf459.8CCL3, TNC, B2M, VCAN, ADCYAP1, ELN
44testosterone45 60 11 2412.8CCL3, B2M, TAC1, TTR, ADCYAP1, ELN
45estrogen459.7TGIF1, CCL3, TNC, B2M, TAC1, TTR
46glucose459.7CCL3, ITGA4, B2M, TTR, VCAN, ADCYAP1
47dexamethasone45 50 29 1112.6CCL3, TNC, ITGA4, TAC1, TTR, ADCYAP1
48retinoic acid45 2410.6PMP22, CCL3, TNC, ITGA4, B2M, TTR
49cysteine459.5PMP22, CCL3, CST7, TNC, B2M, TAC1
50calcium45 50 11 2412.3CCL3, TNC, APCS, ITGA4, B2M, TAC1

GO Terms for genes affiliated with Carpal Tunnel Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.8VCAN, MFGE8, APCS, TNC
2extracellular spaceGO:0056158.7CCL3, TNC, APCS, MFGE8, B2M, TAC1
3extracellular regionGO:0055768.5ELN, CCL3, CST7, TNC, APCS, MFGE8

Biological processes related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.9ELN, VCAN, TTR, TNC

Molecular functions related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.5TGIF1, CCL3, CST7, PSMD9, ITGA4, B2M

Products for genes affiliated with Carpal Tunnel Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carpal Tunnel Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet