MCID: CRP001
MIFTS: 57

Carpal Tunnel Syndrome malady

Genetic diseases (common), Neuronal diseases categories
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Summaries for Carpal Tunnel Syndrome

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MedlinePlus:33 You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. suddenly, a sharp, piercing pain shoots through the wrist and up your arm. just a passing cramp? it could be carpal tunnel syndrome. the carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. it contains nerve and tendons. sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. symptoms usually start gradually. as they worsen, grasping objects can become difficult. often, the cause is having a smaller carpal tunnel than other people do. other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. women are three times more likely to have carpal tunnel syndrome than men. early diagnosis and treatment are important to prevent permanent nerve damage. your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. nih: national institute of neurological disorders and stroke

MalaCards based summary: Carpal Tunnel Syndrome, also known as cts - carpal tunnel syndrome, is related to polyneuropathy and neuropathy. An important gene associated with Carpal Tunnel Syndrome is TTR (transthyretin), and among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and RNA Polymerase I Promoter Opening. The compounds potassium permanganate and thioflavin t have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related mouse phenotypes are hematopoietic system and reproductive system.

CDC:3 Ergonomics is the scientific study of people at work. The goal of ergonomics is to reduce stress and eliminate injuries and disorders associated with the overuse of muscles, bad posture, and repeated tasks. This is accomplished by designing tasks, work spaces, controls, displays, tools, lighting, and equipment to fit the employee´s physical capabilities and limitations.

NINDS:43

Wikipedia:65 Carpal tunnel syndrome (CTS) is a median entrapment neuropathy that causes paresthesia, pain, numbness,... more...

Description from OMIM:46 115430

Aliases & Classifications for Carpal Tunnel Syndrome

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Sources:
8Disease Ontology, 22GTR, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT, 27ICD9CM, 46OMIM, 25ICD10
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Carpal Tunnel Syndrome, Aliases & Descriptions:

Name: Carpal Tunnel Syndrome 8 22 43 10 44 33 62
Cts - Carpal Tunnel Syndrome 8 62
Median Nerve Entrapment 8 62
 
Median Neuropathy, Carpal Tunnel 62
Carpal Tunnel Median Neuropathy 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:12169
MeSH34 D002349
NCIt39 C34450
ICD9CM27 354.0
OMIM46 115430
ICD1025 G56.0

Related Diseases for Carpal Tunnel Syndrome

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Diseases in the Carpal Tunnel Syndrome family:

Carpal Tunnel Syndrome, Familial

Diseases related to Carpal Tunnel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy31.5TTR, PMP22
2neuropathy31.4TTR, PMP22
3amyloidosis31.2TTR, B2M
4arthritis30.4B2M, ADCYAP1, ITGA4
5multiple myeloma30.4ITGA4, B2M
6myeloma30.4ITGA4, ADCYAP1, B2M
7rheumatoid arthritis29.9B2M, ADCYAP1, ITGA4
8ulnar neuropathy10.7
9blindness10.7
10cervicitis10.6
11diabetic polyneuropathy10.6
12thoracic outlet syndrome10.6
13pseudogout10.5
14mononeuropathy10.5
15median neuropathy10.5
16fasciitis10.5
17acromegaly10.4
18radiculopathy10.4
19mucolipidosis10.4
20lipoma10.4
21perineurioma10.4
22synovitis10.4
23hereditary neuropathy with liability to pressure palsies10.4
24eosinophilic fasciitis10.4
25hereditary neuropathy with liability to pressure palsy10.4
26macroglossia10.4
27mycobacterium kansasii10.4
28autonomic dysfunction10.4
29hereditary neuropathies10.4
30chronic inflammatory demyelinating polyneuropathy10.3
31pigmented villonodular synovitis10.3
32epicondylitis10.3
33villonodular synovitis10.3
34intraneural perineurioma10.3
35melorheostosis10.3
36breast cancer10.3
37chondroma10.3
38demyelinating polyneuropathy10.3
39epithelioid sarcoma10.3
40mucopolysaccharidosis10.3
41peripheral neuropathy10.3
42sarcoma10.3
43tuberculosis10.3
44hansen's disease10.3
45chronic pain10.3
46cumulative trauma disorders10.3
47mucopolysaccharidoses10.3
48paresthesia10.3
49carpal tunnel syndrome, familial10.3
50amyloidosis, secondary10.2B2M, TTR

Graphical network of the top 20 diseases related to Carpal Tunnel Syndrome:



Diseases related to carpal tunnel syndrome

Symptoms for Carpal Tunnel Syndrome

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Clinical features from OMIM:

115430

Drugs & Therapeutics for Carpal Tunnel Syndrome

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Drug clinical trials:

Search ClinicalTrials for Carpal Tunnel Syndrome

Search NIH Clinical Center for Carpal Tunnel Syndrome

Genetic Tests for Carpal Tunnel Syndrome

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Genetic tests related to Carpal Tunnel Syndrome:

id Genetic test Affiliating Genes
1 Carpal Tunnel Syndrome22

Anatomical Context for Carpal Tunnel Syndrome

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MalaCards organs/tissues related to Carpal Tunnel Syndrome:

32
Testes, Bone, Skin, Breast, Brain, Kidney

Animal Models for Carpal Tunnel Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Carpal Tunnel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0ITGA4, ADCYAP1, B2M, MFGE8
2MP:00053897.8MFGE8, B2M, PMP22, ADCYAP1
3MP:00053847.4ITGA4, ADCYAP1, PMP22, B2M, MFGE8

Publications for Carpal Tunnel Syndrome

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Articles related to Carpal Tunnel Syndrome:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Acute effect of topical menthol on chronic pain in slaughterhouse workers with carpal tunnel syndrome: triple-blind, randomized placebo-controlled trial. (25298894)
2014
2
Asymptomatic carpal tunnel syndrome in obese and overweight patients with metabolic syndrome. (23291805)
2013
3
Methylprednisolone injections for the carpal tunnel syndrome. (24343399)
2013
4
A manual therapy intervention improves symptoms in patients with carpal tunnel syndrome: a pilot study. (23064542)
2013
5
Median nerve ultrasound in diabetic peripheral neuropathy with and without carpal tunnel syndrome. (23401087)
2013
6
Re: Zyluk A. and Szlosser Z. The results of carpal tunnel release for carpal tunnel syndrome diagnosed on clinical grounds, with or without electrophysiological investigations: a randomized study. J Hand Surg Eur. 2013, 38: 44-9. (23778068)
2013
7
Carpal tunnel syndrome induced by a solitary osteochondral body: a case report. (23412011)
2013
8
Ultrasound as a first-line test in the diagnosis of carpal tunnel syndrome: a cost-effectiveness analysis. (23129465)
2013
9
Cross-cultural adaptation of the Korean version of the Boston carpal tunnel questionnaire: its clinical evaluation in patients with carpal tunnel syndrome following local corticosteroid injection. (23853496)
2013
10
Synovial Angioma of the FDP Flexor Sheath: A Rare Cause of Carpal Tunnel Syndrome. (23569470)
2013
11
Carpal tunnel syndrome in patients on intermittent hemodialysis. (23306634)
2012
12
New advances in the mechanisms and etiology of carpal tunnel syndrome. (22642915)
2012
13
Comparison of surgical decompression and local steroid injection in the treatment of carpal tunnel syndrome: 2-year clinical results from a randomized trial. (22467087)
2012
14
Hand-held nerve conduction device in carpal tunnel syndrome: a prospective study. (22499088)
2012
15
Prevalence of self-reported symptoms compatible with carpal tunnel syndrome (CTS) among employees at a neonatal intensive care unit: a cross-sectional study. (22619986)
2012
16
Acute carpal tunnel syndrome following a burn in a patient with McArdle's disease: a case report. (22770756)
2012
17
The segmental palmar test in diagnosing carpal tunnel syndrome reassessed. (22608474)
2012
18
Randomized controlled trial comparing acupuncture with placebo acupuncture for the treatment of carpal tunnel syndrome. (22405683)
2012
19
A blinded placebo-controlled randomized trial on the use of astaxanthin as an adjunct to splinting in the treatment of carpal tunnel syndrome. (23449748)
2012
20
Effects of carpal tunnel syndrome on adaptation of multi-digit forces to object mass distribution for whole-hand manipulation. (23171737)
2012
21
Difficulty of pinching behind the back: an atypical symptom of carpal tunnel syndrome related to a specific wrist position. Two case reports. (22522337)
2012
22
Carpal tunnel syndrome in pregnancy. (23026467)
2012
23
Advanced glycation end products and I^(2)-microglobulin as predictors of carpal tunnel syndrome in hemodialysis patients. (22699860)
2012
24
Performance of simplified scoring systems for hand diagrams in carpal tunnel syndrome screening. (21975100)
2012
25
The Strain Index (SI) and Threshold Limit Value (TLV) for Hand Activity Level (HAL): risk of carpal tunnel syndrome (CTS) in a prospective cohort. (22397385)
2012
26
Ultrasound-guided percutaneous surgery for carpal tunnel syndrome: a cadaver study. (21276741)
2011
27
JAMA patient page. Carpal tunnel syndrome. (22110111)
2011
28
Venous malformation involving median nerve causing acute carpal tunnel syndrome. (21490029)
2011
29
Repeated electrophysiologic studies in patients with carpal tunnel syndrome following local corticosteroid injection using a novel approach. (21446232)
2011
30
Usefulness of ultrasonography to predict response to injection therapy in carpal tunnel syndrome. (22506149)
2011
31
Carpal tunnel syndrome as an occupational disease by Dr. med. Klaus Giersiepen und Dr. med. Michael Spallek in volume 14/2011. Recognize acromegaly. (21776313)
2011
32
Sonographic diagnosis of carpal tunnel syndrome--diagnostic value of the triangular cross-section sign. (22212985)
2011
33
Association of disturbances in the thoracic outlet in subjects with carpal tunnel syndrome: a case-control study. (21272763)
2011
34
Information from your family doctor. Carpal tunnel syndrome. (21524036)
2011
35
Factors affecting return to work after carpal tunnel syndrome surgery in a large French cohort. (22032220)
2011
36
Letter to the editor: The sensitivity and specificity of ultrasound for the diagnosis of carpal tunnel syndrome: a meta-analysis. (21210308)
2011
37
The ultrasonographic correlates of carpal tunnel syndrome in patients with normal electrodiagnostic tests. (21293941)
2011
38
Bilateral carpal tunnel syndrome and ulnar neuropathy at the elbow in a pizza chef. (21686375)
2009
39
The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy. (19626479)
2009
40
Electrodiagnosis as an extension of the physical examination: identifying proximal median neuropathy in the setting of carpal tunnel syndrome. (18806514)
2008
41
MMP-2 expression is associated with rapidly proliferative arteriosclerosis in the flexor tenosynovium and pain severity in carpal tunnel syndrome. (15685708)
2005
42
Macroglossia and carpal tunnel syndrome associated with multiple myeloma: a case report. (16285349)
2005
43
The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. (15538733)
2004
44
Monophasic negative sympathetic skin responses and autonomic dysfunction in carpal tunnel syndrome. (14755503)
2004
45
Acute carpal tunnel syndrome caused by calcific periarthritis of the wrist. (11247312)
2001
46
Biochemical and histological analysis of the flexor tenosynovium in patients with carpal tunnel syndrome. (9731366)
1997
47
Palpatory diagnosis and manipulative management of carpal tunnel syndrome: Part 2. 'Double crush' and thoracic outlet syndrome. (7673008)
1995
48
An unusual case of transient papular mucinosis associated with carpal tunnel syndrome. (8369216)
1993
49
The recurrent carpal tunnel syndrome. (8368039)
1993
50
Periosteal chondroma: another cause of carpal tunnel syndrome. (6721390)
1984

Variations for Carpal Tunnel Syndrome

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Expression for genes affiliated with Carpal Tunnel Syndrome

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Expression patterns in normal tissues for genes affiliated with Carpal Tunnel Syndrome

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Pathways for genes affiliated with Carpal Tunnel Syndrome

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Compounds for genes affiliated with Carpal Tunnel Syndrome

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Compounds related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1potassium permanganate449.9B2M, TTR
2thioflavin t449.9TTR, B2M
3cellulose acetate449.9B2M, TTR
425-hydroxyvitamin d449.9B2M, TTR
5phosphorus449.9TTR, B2M
6vitamin b12449.9TTR, B2M
7neopterin449.9B2M, TTR
8theophylline44 28 24 1112.9TTR, B2M
9uric acid44 2410.8TTR, B2M
10vitamin-e449.8TTR, B2M
11chlorine44 2410.7TTR, B2M
12urea44 24 1111.7B2M, TTR
13lead449.7ITGA4, B2M
14vincristine44 50 1111.6ITGA4, B2M
15lutein449.6TTR, ADCYAP1
16thyroxine44 2410.4TTR, B2M
17genistein44 28 61 2 24 1114.4ITGA4, TTR, B2M
18dihydrotestosterone44 28 24 1112.3PMP22, ADCYAP1
19hyaluronic acid44 2410.2TTR, B2M
20nifedipine44 28 50 1112.2ADCYAP1, B2M
21cgmp44 2810.1ITGA4, ADCYAP1
22inositol 1,4,5 trisphosphate449.1ITGA4, ADCYAP1
23testosterone44 61 24 1112.0ADCYAP1, TTR, B2M
24arginine449.0PMP22, TTR, ADCYAP1
25dexamethasone44 50 28 1112.0ITGA4, ADCYAP1, TTR
26steroid449.0B2M, PMP22, ADCYAP1
27cycloheximide448.9ITGA4, ADCYAP1, B2M
28glucose448.6ITGA4, ADCYAP1, TTR, B2M
29aspartate448.1ITGA4, ADCYAP1, TTR, PMP22, B2M
30retinoic acid44 249.1B2M, PMP22, TTR, ADCYAP1, ITGA4
31serine448.1ITGA4, ADCYAP1, TTR, PMP22, B2M

GO Terms for genes affiliated with Carpal Tunnel Syndrome

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Cellular components related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7ITGA4, B2M, MFGE8
2extracellular regionGO:0055768.1ADCYAP1, TTR, B2M, MFGE8
3extracellular spaceGO:0056157.8MFGE8, B2M, TTR, ADCYAP1

Biological processes related to Carpal Tunnel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.4ITGA4, B2M

Products for genes affiliated with Carpal Tunnel Syndrome

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  • Antibodies
  • Proteins
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Sources for Carpal Tunnel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet