MCID: CRR001
MIFTS: 39

Carrion's Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

MalaCards integrated aliases for Carrion's Disease:

Name: Carrion's Disease 12 14
Oroya Fever 12 55 3 69
Carrion Disease 12 55
Bartonellosis Due to Bartonella Bacilliformis Infection 55
Bartonella Infections 69

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
Orphanet 55 ORPHA64692
UMLS via Orphanet 70 C0029307 C0348974
MESH via Orphanet 42 D001474
ICD10 via Orphanet 33 A44.0
ICD10 32 A44.9
UMLS 69 C0029307

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results_in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to cat-scratch disease and sennetsu fever. An important gene associated with Carrion's Disease is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include endothelial cells or, endothelial and liver.

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Gentamicins Phase 3
12 Antibodies
13 Immunoglobulins
14 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
3 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

18
Endothelial Cells Or

MalaCards organs/tissues related to Carrion's Disease:

38
Endothelial, Liver

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show all 22)
# Title Authors Year
1
Carrion's Disease: the Sound of Silence. ( 29187394 )
2018
2
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru. ( 28628613 )
2017
3
Carrion's Disease: More Than a Sand Fly-Vectored Illness. ( 27736978 )
2016
4
Carrion's disease: an eradicable illness? ( 27903286 )
2016
5
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? ( 26706684 )
2015
6
Carrion's disease after blood transfusion. ( 26674821 )
2015
7
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. ( 24847360 )
2014
8
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. ( 24651298 )
2014
9
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. ( 23409255 )
2013
10
Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru. ( 15286824 )
2004
11
Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update. ( 15798808 )
2004
12
Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic. ( 15297516 )
2004
13
Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease. ( 2428261 )
1986
14
A case of Carrion's disease associated with human sacrifice from the Huari culture of Southern Peru. ( 4606100 )
1974
15
Pathogenesis of the verruga of Carrion's disease. Ultrastructural studies. ( 5060580 )
1972
16
Carrion's disease treated with chloromycetin. ( 24540616 )
1951
17
A study of 22 cases of Carrion's disease with intercurrent malaria. ( 15392068 )
1949
18
Intercurrent infections of Carrion's disease observed in Peru. ( 18859832 )
1948
19
The treatment of Carrion's disease with large transfusions. ( 20284814 )
1947
20
Penicillin therapy in human bartonellosis (Carrion's disease). ( 21007299 )
1945
21
ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE. ( 19869598 )
1929
22
ETIOLOGY OF OROYA FEVER : X. COMPARATIVE STUDIES OF DIFFERENT STRAINS OF BARTONELLA BACILLIFORMIS, WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE CLINICAL TYPES OF CARRION'S DISEASE AND THE VIRULENCE OF THE INFECTING ORGANISM. ( 19869408 )
1928

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

GO Terms for Carrion's Disease

Cellular components related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CCL11 CD40LG CXCL10 CXCL9 EGF HMOX1

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CCL11 CD40LG CXCL10 CXCL9 IL15
2 response to ethanol GO:0045471 9.61 MT-CYB MT-ND4 OGG1
3 positive regulation of interleukin-10 production GO:0032733 9.46 CD40LG HSPD1
4 positive regulation of cAMP-mediated signaling GO:0043950 9.4 CXCL10 CXCL9
5 positive regulation of cAMP metabolic process GO:0030816 9.37 CXCL10 CXCL9
6 regulation of receptor activity GO:0010469 9.35 CCL11 CD40LG CXCL10 CXCL9 IL15
7 chemokine-mediated signaling pathway GO:0070098 9.33 CCL11 CXCL10 CXCL9
8 T cell chemotaxis GO:0010818 9.32 CXCL10 CXCL9
9 inflammatory response GO:0006954 9.02 CCL11 CD40LG CXCL10 CXCL9 IL15

Molecular functions related to Carrion's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL11 CXCL10 CXCL9
2 cytokine activity GO:0005125 9.02 CCL11 CD40LG CXCL10 CXCL9 IL15
3 CXCR3 chemokine receptor binding GO:0048248 8.96 CXCL10 CXCL9

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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