MCID: CRR001
MIFTS: 37

Carrion's Disease malady

Infectious diseases category

Summaries for Carrion's Disease

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8Disease Ontology, 3CDC, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in endothelial cells or located in red blood cells, has material basis in bartonella bacilliformis, which is transmitted by sandflies of genus lutzomyia. the infection has acute and chronic phases. the acute phase is characterized by severe hemolytic anemia and transient immunosuppression. the chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards: Carrion's Disease, also known as oroya fever, is related to cat-scratch disease and granulomatous hepatitis. An important gene associated with Carrion's Disease is MT-ND4 (mitochondrially encoded NADH dehydrogenase 4). The compounds 8-azido-atp and amp-pnp have been mentioned in the context of this disorder. Affiliated tissues include endothelial cells or and endothelial.

CDC:3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión's disease, caused by B. bacilliformis.

Aliases & Classifications for Carrion's Disease

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

carrion's disease 8
oroya fever 8 48 60
bartonellosis due to bartonella bacilliformis infection 48
bartonella infections 60
carrions disease 10
carrion disease 48


External Ids:

Disease Ontology8 DOID:0050398
MESH via Orphanet35 D001474
ICD10 via Orphanet26 A44.0
SNOMED-CT via Orphanet57 186825001, 240453002, 262461007
UMLS via Orphanet61 C0029307, C0348974
ICD1025 A44, A44.9

Related Diseases for Carrion's Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Carrion's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1cat-scratch disease10.4
2granulomatous hepatitis10.2
3hepatitis a10.2
4hepatitis10.2
5trench fever10.0
6juvenile rheumatoid arthritis10.0
7granuloma annulare10.0
8arthritis10.0
9endocarditis10.0
10infective endocarditis10.0
11meningitis10.0
12panniculitis10.0
13rheumatoid arthritis10.0
14blindness10.0MT-ND4
15colorectal cancer10.0HSPE1
16cystic fibrosis10.0HSPE1

Graphical network of diseases related to Carrion's Disease:



Diseases related to carrion's disease

Clinical Features for Carrion's Disease

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Drugs & Therapeutics for Carrion's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Carrion's Disease

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Anatomical Context for Carrion's Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Carrion's Disease:

32
Endothelial

FMA organs/tissues related to Carrion's Disease:

14
Endothelial cells or

Animal Models for Carrion's Disease or affiliated genes

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Publications for Carrion's Disease

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Sources:
50PubMed
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Articles related to Carrion's Disease:

(show all 13)
idTitleAuthorsYear
1
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. (23409255)
2013
2
Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru. (15286824)
2004
3
Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic. (15297516)
2004
4
Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update. (15798808)
2004
5
Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease. (2428261)
1986
6
A case of Carrion's disease associated with human sacrifice from the Huari culture of Southern Peru. (4606100)
1974
7
Pathogenesis of the verruga of Carrion's disease. Ultrastructural studies. (5060580)
1972
8
A study of 22 cases of Carrion's disease with intercurrent malaria. (15392068)
1949
9
Intercurrent infections of Carrion's disease observed in Peru. (18859832)
1948
10
The treatment of Carrion's disease with large transfusions. (20284814)
1947
11
Penicillin therapy in human bartonellosis (Carrion's disease). (21007299)
1945
12
ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE. (19869598)
1929
13
ETIOLOGY OF OROYA FEVER : X. COMPARATIVE STUDIES OF DIFFERENT STRAINS OF BARTONELLA BACILLIFORMIS, WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE CLINICAL TYPES OF CARRION'S DISEASE AND THE VIRULENCE OF THE INFECTING ORGANISM. (19869408)
1928

Genetic Variations for Carrion's Disease

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Expression for genes affiliated with Carrion's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for genes affiliated with Carrion's Disease

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Compounds for genes affiliated with Carrion's Disease

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44Novoseek, 28IUPHAR, 24HMDB
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Compounds related to Carrion's Disease according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
18-azido-atp449.6HSPD1, HSPE1
2amp-pnp44 2810.5HSPD1, HSPE1
3mgatp449.5HSPD1, HSPE1
4malate449.4HSPD1, HSPE1
5guanidine hydrochloride449.4HSPD1, HSPE1
6phorbol449.3ADORA2A, HSPD1
7citrate449.3HSPD1, HSPE1
8gold449.2HSPE1, HSPD1
9pyruvate449.1MT-ND4, HSPD1, HSPE1
10lactate449.0HSPE1, HSPD1, MT-ND4
11atp44 289.6HSPE1, HSPD1, MT-ND4, ADORA2A
12adp44 28 2410.5ADORA2A, HSPD1, HSPE1

GO Terms for genes affiliated with Carrion's Disease

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Sources:
16Gene Ontology
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Biological processes related to Carrion's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.3HSPD1, HSPE1
2response to unfolded proteinGO:0069869.0HSPD1, HSPE1

Molecular functions related to Carrion's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1unfolded protein bindingGO:0510829.3HSPD1, HSPE1
2chaperone bindingGO:0510879.0HSPD1, HSPE1

Products for genes affiliated with Carrion's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Carrion's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet