MCID: CRR001
MIFTS: 34

Carrion's Disease malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Carrion's Disease

Aliases & Descriptions for Carrion's Disease:

Name: Carrion's Disease 12 14
Oroya Fever 12 56 3 69
Carrion Disease 12 56
Bartonellosis Due to Bartonella Bacilliformis Infection 56
Bartonella Infections 69

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050398
Orphanet 56 ORPHA64692
MESH via Orphanet 43 D001474
UMLS via Orphanet 70 C0029307 C0348974
ICD10 via Orphanet 34 A44.0
ICD10 33 A44.9

Summaries for Carrion's Disease

Disease Ontology : 12 A bartonellosis that results_in infection located in endothelial cells or located in red blood cells, has material basis in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

MalaCards based summary : Carrion's Disease, also known as oroya fever, is related to cat-scratch disease and early congenital syphilis. An important gene associated with Carrion's Disease is ASXL3 (Additional Sex Combs Like 3, Transcriptional Regulator), and among its related pathways/superpathways is Malaria. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include endothelial and endothelial cells or.

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Related Diseases for Carrion's Disease

Graphical network of the top 20 diseases related to Carrion's Disease:



Diseases related to Carrion's Disease

Symptoms & Phenotypes for Carrion's Disease

Drugs & Therapeutics for Carrion's Disease

Drugs for Carrion's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
2
Prednisone Approved, Vet_approved Phase 4,Phase 3 53-03-2 5865
3
Arsenic trioxide Approved, Investigational Phase 4 1327-53-3 518740
4
Asparaginase Approved Phase 4 9015-68-3
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 3 50-18-0, 6055-19-2 2907
6
Cytarabine Approved, Investigational Phase 4 147-94-4 6253
7
Daunorubicin Approved Phase 4 20830-81-3 30323
8
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
9
Vincristine Approved, Investigational Phase 4,Phase 3 2068-78-2, 57-22-7 5978
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
11
Bevacizumab Approved, Investigational Phase 4 216974-75-3
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
13
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Antineoplastic Agents, Hormonal Phase 4,Phase 3
16 glucocorticoids Phase 4,Phase 3
17 Hormone Antagonists Phase 4,Phase 3
18 Hormones Phase 4,Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2
21 Anti-Bacterial Agents Phase 4,Phase 3,Early Phase 1
22 Antibiotics, Antitubercular Phase 4,Early Phase 1
23 Folic Acid Antagonists Phase 4
24 Topoisomerase Inhibitors Phase 4
25 Vitamin B Complex Phase 4
26 Antiviral Agents Phase 4
27 Imatinib Mesylate Phase 4 123596
28 Interferon-alpha Phase 4,Phase 3
29 interferons Phase 4,Phase 3
30 Protein Kinase Inhibitors Phase 4
31 6-Mercaptopurine Phase 4
32 Alkylating Agents Phase 4
33 Antimetabolites Phase 4
34 Antimetabolites, Antineoplastic Phase 4
35 Antimitotic Agents Phase 4,Phase 3,Phase 2
36 Antineoplastic Agents, Alkylating Phase 4
37 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2
38 Antirheumatic Agents Phase 4
39 Dermatologic Agents Phase 4
40 Immunosuppressive Agents Phase 4,Phase 3
41 Nucleic Acid Synthesis Inhibitors Phase 4
42 Antiemetics Phase 4,Phase 3
43 Autonomic Agents Phase 4,Phase 3
44 BB 1101 Phase 4,Phase 3
45 Dexamethasone 21-phosphate Phase 4,Phase 3
46 Dexamethasone acetate Phase 4,Phase 3 1177-87-3
47 Gastrointestinal Agents Phase 4,Phase 3
48 Peripheral Nervous System Agents Phase 4,Phase 3
49 Folate Nutraceutical Phase 4
50 Vitamin B9 Nutraceutical Phase 4

Interventional clinical trials:

(show all 38)
id Name Status NCT ID Phase
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4
2 Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO) Completed NCT00504764 Phase 4
3 Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec®-Interferon Alpha in the Treatment of Chronic-Phase Chronic Myeloid Leukaemia Completed NCT00390897 Phase 4
4 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4
5 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4
6 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4
7 Resection vs no Resection of the Primary in Colorectal Cancer With Unresectable Metastases Recruiting NCT02015923 Phase 4
8 Brazilian Intervention to Increase Evidence Usage in Practice - Stroke ( BRIDGE-Stroke) Recruiting NCT02223273 Phase 4
9 Subcutaneous Immunotherapy Treatment for Patients With Hypersensitivity to Grass Pollen Completed NCT00916422 Phase 3
10 An Open Trial to Assess the Tolerability of AVANZ Phleum Pratense Immunotherapy Completed NCT01454531 Phase 2, Phase 3
11 GEM05 for Patients With Multiple Myeloma Under 65 Years Completed NCT00461747 Phase 3
12 A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients Recruiting NCT02111564 Phase 3
13 Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment Recruiting NCT02548351 Phase 3
14 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Not yet recruiting NCT03132116 Phase 3
15 HOPE-Epilepsy Trial Suspended NCT01744275 Phase 2, Phase 3
16 A Placebo-controlled, Phase 2 Trial to Evaluate OPC 67683 in Patients With Pulmonary Sputum Culture-positive, Multidrug-resistant Tuberculosis (TB) Completed NCT00685360 Phase 2
17 Neurotoxicity Characterization Study of Nab-paclitaxel Versus Conventional Paclitaxel in Metastatic Breast Cancer Completed NCT01763710 Phase 2
18 Study of Nitazoxanide Tablets in the Treatment of Mild to Moderate Active Crohn's Disease Terminated NCT00130390 Phase 2
19 Clinical Pathway With "Fast-Track" In Uncomplicated Acute Appendicitis Unknown status NCT02326415
20 Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903
21 Improvement of Transient Elastography Applicability and Diagnostic Accuracy to Identify Significant Fibrosis by Experienced Operators Using the M and XL Probe. Completed NCT01900808
22 Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador Completed NCT00279331
23 Gluten-free Diet Monitoring in Urine Completed NCT02344758 Early Phase 1
24 Assessment of the Effects of Different Implant Abutment Occluding Materials on Dental Implant Health Parameters and Microbiology Completed NCT02625597
25 Evaluation of the Coloplast Titan® IPP for Maintaining Penile Length While Treating Erectile Dysfunction (ED) Completed NCT00731666
26 Effects of Modified Constraint Induced Movement Therapy on Infantile Hemiplegia Completed NCT02178371
27 Third International Study on Mechanical Ventilation Completed NCT01093482
28 Bartonella in Liver Transplant Patients Recruiting NCT02595710
29 Study to Evaluate the Effect of a Vegetal Oil on Cognitive Impairment Recruiting NCT02778581
30 Irrigation Versus Suction in Complicated Acute Appendicitis Recruiting NCT02688244
31 Effectiveness, Safety and Clinical Outcomes of Paritaprevir/Ombitasvir/r+Dasabuvir 8 Weeks Recruiting NCT03122132
32 TIPS in Fundal Variceal Bleeding (the TFB Study) Recruiting NCT02364297
33 A Prospective Colorectal Liver Metastasis Database With an Integrated Quality Assurance Program Recruiting NCT02218801
34 HBsAg Loss Adding Pegylated Interferon in HBeAg-negative Patients Active, not recruiting NCT02743182
35 Impact of Antiviral Therapy on Gastroesophageal Varices. Active, not recruiting NCT02758509
36 ISOperistaltic Versus ANTIperistaltic Anastomosis After Laparoscopic Right Colectomy for Cancer Active, not recruiting NCT02309931
37 Child Characteristics, Neuromarkers, and Intervention Components Impacting Treatment Outcome: CCT, TF-CBT, TAU Not yet recruiting NCT02926677
38 Brazilian inteRvention to Increase eviDence usaGe in practicE - Cardiovascular Prevention Not yet recruiting NCT02851732

Search NIH Clinical Center for Carrion's Disease

Genetic Tests for Carrion's Disease

Anatomical Context for Carrion's Disease

MalaCards organs/tissues related to Carrion's Disease:

39
Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Carrion's Disease:

18
Endothelial Cells Or

Publications for Carrion's Disease

Articles related to Carrion's Disease:

(show all 20)
id Title Authors Year
1
Carrion's disease: an eradicable illness? ( 27903286 )
2016
2
Carrion's Disease: More Than a Sand Fly-Vectored Illness. ( 27736978 )
2016
3
Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America? ( 26706684 )
2015
4
Carrion's disease after blood transfusion. ( 26674821 )
2015
5
Diagnosis of Carrion's disease by direct blood PCR in thin blood smear negative samples. ( 24651298 )
2014
6
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion's Disease in Amazonas, Peru. ( 24847360 )
2014
7
Whole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion's Disease. ( 23409255 )
2013
8
Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru. ( 15286824 )
2004
9
Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic. ( 15297516 )
2004
10
Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update. ( 15798808 )
2004
11
Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease. ( 2428261 )
1986
12
A case of Carrion's disease associated with human sacrifice from the Huari culture of Southern Peru. ( 4606100 )
1974
13
Pathogenesis of the verruga of Carrion's disease. Ultrastructural studies. ( 5060580 )
1972
14
Carrion's disease treated with chloromycetin. ( 24540616 )
1951
15
A study of 22 cases of Carrion's disease with intercurrent malaria. ( 15392068 )
1949
16
Intercurrent infections of Carrion's disease observed in Peru. ( 18859832 )
1948
17
The treatment of Carrion's disease with large transfusions. ( 20284814 )
1947
18
Penicillin therapy in human bartonellosis (Carrion's disease). ( 21007299 )
1945
19
ETIOLOGY OF OROYA FEVER : XIV. THE INSECT VECTORS OF CARRION'S DISEASE. ( 19869598 )
1929
20
ETIOLOGY OF OROYA FEVER : X. COMPARATIVE STUDIES OF DIFFERENT STRAINS OF BARTONELLA BACILLIFORMIS, WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE CLINICAL TYPES OF CARRION'S DISEASE AND THE VIRULENCE OF THE INFECTING ORGANISM. ( 19869408 )
1928

Variations for Carrion's Disease

Expression for Carrion's Disease

Search GEO for disease gene expression data for Carrion's Disease.

Pathways for Carrion's Disease

Pathways related to Carrion's Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.49 CD40LG GYPA GYPB

GO Terms for Carrion's Disease

Cellular components related to Carrion's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.1 FH HSPD1 HSPE1 MT-CYB MT-ND4 OGG1

Biological processes related to Carrion's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to nicotine GO:0035094 9.4 HMOX1 MT-ND4
2 B cell proliferation GO:0042100 9.37 CD40LG HSPD1
3 cellular response to cadmium ion GO:0071276 9.32 HMOX1 OGG1
4 positive regulation of interleukin-12 production GO:0032735 9.26 CD40LG HSPD1
5 positive regulation of interleukin-10 production GO:0032733 9.16 CD40LG HSPD1
6 response to ethanol GO:0045471 9.13 MT-CYB MT-ND4 OGG1
7 chaperone mediated protein folding requiring cofactor GO:0051085 8.62 HSPD1 HSPE1

Sources for Carrion's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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