MCID: CST002
MIFTS: 42

Castleman's Disease malady

Rare diseases, Immune diseases, Cancer diseases, Infectious diseases categories

Aliases & Classifications for Castleman's Disease

About this section

Aliases & Descriptions for Castleman's Disease:

Name: Castleman's Disease 42
Angiofollicular Ganglionic Hyperplasia 42 61
 
Angiofollicular Lymph Hyperplasia 42
Angiolymphoid Hyperplasia 61


Classifications:



Summaries for Castleman's Disease

About this section
NIH Rare Diseases:42 Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. while the cause of castleman's disease is unknown, many doctors suspect a virus is involved. problems with the way an individual's immune system functions may also contribute to the development of the condition. there are 2 main forms of castleman's disease: localized (discussed here) and multicentric. they affect people very differently. localized or unicentric castleman's disease only affects a single set of lymph nodes and is not widespread. the lymph nodes that are more commonly affected are in the chest and abdomen. castleman’s disease causes the lymph nodes to get larger. the enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. people with localized castleman's disease are often cured when the lymph node is removed with surgery. chemotherapy and radiation may also be used. last updated: 4/25/2012

MalaCards based summary: Castleman's Disease, also known as angiofollicular ganglionic hyperplasia, is related to multicentric castleman’s disease and angiofollicular lymph hyperplasia. An important gene associated with Castleman's Disease is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Transcription Androgen Receptor nuclear signaling and IL-17 Family Signaling Pathways. The compounds turpentine and iron sucrose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and lung, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Castleman's Disease

About this section

Diseases in the Castleman's Disease family:

Localized Castleman Disease

Diseases related to Castleman's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1multicentric castleman’s disease31.1IL6R, IL6
2angiofollicular lymph hyperplasia10.6
3classic kaposi sarcoma10.4IL6
4aortic aneurysm10.4CRP
5bronchitis10.4CRP
6bacteriuria10.4CRP
7crohn's disease10.4CRP
8systemic lupus erythematosus10.3CRP
9plasmacytoma10.3IL6R, IL6
10adult-onset still's disease10.3CRP, IL6
11viral meningitis10.2CRP, IL6
12chorioamnionitis10.2IL6, CRP
13pulmonary disease, chronic obstructive10.2CRP, IL6
14eye disease10.2IL6, CRP
15kaposi sarcoma10.2IL6R, IL6
16juvenile rheumatoid arthritis10.2CRP, IL6
17respiratory failure10.2CRP, IL6
18thrombocytosis10.2IL6, CRP
19meningitis10.2IL6, CRP
20leukopenia10.2IL6, CRP
21peritonitis10.2IL6, CRP
22nutritional deficiency disease10.2IL6, CRP
23synovitis10.2CRP, IL6
24acute pancreatitis10.2CRP, IL6
25periodontal disease10.2IL6, CRP
26rheumatic disease10.2IL6R, CRP
27lipid metabolism disorder10.2IL6, CRP
28multiple myeloma10.2IL6R, IL6
29colitis10.2IL6, IL6R
30pancreatitis10.2IL6, CRP
31liver disease10.1CRP, IL6
32congenital heart disease10.1IL6, CRP
33coronary artery disease10.1CRP, IL6
34ulcerative colitis10.0IL6, IL6R, CRP
35inflammatory bowel disease10.0CRP, IL6R, IL6
36endometriosis10.0IL6, IL6R
37osteoarthritis10.0IL6, IL6R, CRP
38diabetes mellitus, noninsulin-dependent10.0CRP, IL6R, IL6
39arthritis10.0CRP, IL6R, IL6
40obesity10.0CRP, IL6R, IL6
41multiple sclerosis, disease progression, modifier of10.0IL6R, IL9, IL6
42atherosclerosis10.0IL6, IL6R, CRP
43rheumatoid arthritis10.0CRP, IL6R, IL6
44burkitt lymphoma9.9CR2, IL6R
45allergic asthma9.9CR2, IL9
46hodgkin lymphoma9.9IL6R, IL9
47ipex syndrome9.8CR2, IL6R, IL6
48lymphoma, non-hodgkin9.8CR2, IL6R, IL9
49hypersensitivity reaction type ii disease9.4EVPL, CR2, IL6R, IL9, IL6
50leukemia9.4IL6, IL9, IL6R, CR2, EVPL

Graphical network of the top 20 diseases related to Castleman's Disease:



Diseases related to castleman's disease

Symptoms for Castleman's Disease

About this section

Drugs & Therapeutics for Castleman's Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Castleman's Disease

Search NIH Clinical Center for Castleman's Disease

Genetic Tests for Castleman's Disease

About this section

Anatomical Context for Castleman's Disease

About this section

MalaCards organs/tissues related to Castleman's Disease:

31
Lymph node, B cells, Lung, Kidney, T cells, Endothelial, Liver, Skin, Spleen, Pancreas, Breast, Heart, Colon, Adrenal gland, Ovary, Monocytes, Tongue

Animal Models for Castleman's Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Castleman's Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CR2, IL6R, IL9, IL6
2MP:00053877.5CR2, CRP, IL6R, IL9, IL6
3MP:00053767.3IL6, IL9, IL6R, CRP, CR2

Publications for Castleman's Disease

About this section

Articles related to Castleman's Disease:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Durable remission with rituximab in a patient with an unusual variant of Castleman's disease with myelofibrosis -TAFRO syndrome. (25808231)
2015
2
Successful use of tocilizumab in a case of multicentric Castleman's disease and end-stage renal disease. (24571441)
2014
3
Clinical features and outcomes in patients with human immunodeficiency virus-negative, multicentric Castleman's disease: a single medical center experience. (25548759)
2014
4
Retroperitoneal unicentric Castleman's disease-a hyaline vascular challenge. (25118641)
2014
5
Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient. (25169666)
2014
6
Castleman's disease mimicked gynaecological adnexal tumour. (24831584)
2014
7
Reversal of cardiomyopathy with tocilizumab in a case of HIV-negative Castleman's disease. (23786462)
2013
8
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
9
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
10
The spectrum of Castleman's disease: mimics, radiologic pathologic correlation and role of imaging in patient management. (20643523)
2012
11
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease. (23102767)
2012
12
Castleman's Disease: A Case Report of the Unicentric Type. (22991681)
2012
13
The characterization and management of Castleman's disease. (22971511)
2012
14
Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report. (21577263)
2011
15
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
16
Retroperitoneal unicentric Castleman's disease with multiple lymph node involvement. (22696693)
2011
17
Solitary intra-abdominal Castleman's disease, hyaline vascular type: case report. (20164010)
2010
18
Highly active antiretroviral therapy alone may be an effective treatment for HIV-associated multi-centric Castleman's disease. (20801900)
2010
19
Castleman's disease of the parotid gland: a case report. (20705256)
2010
20
Castleman's disease in the head and neck region: Meta-analysis of reported cases in Taiwan and literature review. (21195890)
2010
21
Castleman's disease: a study of a rare lymphoproliferative disorder in a university hospital. (20164006)
2010
22
Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report. (20205844)
2010
23
Vinblastine, rituximab and HAART, treatment of an HIV -positive patient with multicentric Castleman's disease. (20167961)
2010
24
The analysis of interleukin-6 in patients with systemic IgG4-related plasmacytic syndrome--expansion of SIPS to the territory of Castleman's disease. (19447768)
2009
25
Splenectomy-induced long-term remission in a patient with multicentric Castleman's disease. (19767666)
2009
26
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
27
Castleman's disease: an intrapulmonary form with intrafissural development. (19768350)
2009
28
A rare case of Castleman's disease of plasma cell type within kidney. (20079147)
2009
29
Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection. (19298351)
2009
30
Hyaline vascular-type Castleman's disease of the retroperitoneum. (18677335)
2008
31
Multicentric Castleman's disease presenting with multiple nodes in lungs: a case report and literature review. (18815726)
2008
32
Unicentric Castleman's disease in peripancreatic tissue: case report and review of the literature. (18419976)
2008
33
FDG-PET and diffusion-weighted MR imaging appearance in retroperitoneal Castleman's disease: a case report. (18313580)
2008
34
Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease. (17541233)
2007
35
Castleman's disease of the axilla mimicking metastasis. (17996608)
2007
36
Castleman's disease and retroviral therapy. (17931977)
2007
37
Are multicentric Castleman's disease with cutaneous plasmacytosis and systemic plasmacytosis the same entity? (17064311)
2006
38
Interfollicular Hodgkin's lymphoma and Castleman's disease. (16430484)
2006
39
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
40
Castleman's disease as an unusual neck mass: case report. (15224829)
2004
41
Castleman's disease. (14585575)
2003
42
Hyaline vascular Castleman's disease: a case report and brief review of the literature. (12685494)
2002
43
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10702388)
2000
44
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
45
Castleman's disease. (10655569)
1999
46
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
47
Castleman's disease in a 44-year-old male with neurofibromatosis and pheochromocytoma. (9477139)
1997
48
A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects. (8695726)
1996
49
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
50
Angiofollicular lymph node hyperplasia (Castleman's disease) in an adolescent female. Clinical and immunologic findings. (1873789)
1991

Variations for Castleman's Disease

About this section

Expression for genes affiliated with Castleman's Disease

About this section
Search GEO for disease gene expression data for Castleman's Disease.

Pathways for genes affiliated with Castleman's Disease

About this section

Pathways related to Castleman's Disease according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.6IL6R, IL6
2
Show member pathways
9.6IL6R, IL6
39.6IL6R, IL6
49.6IL6, IL6R
5
Show member pathways
9.6IL6R, IL6
69.6IL6R, IL6
7
Show member pathways
9.6IL6R, IL6
8
Show member pathways
9.6IL6R, IL6
99.6IL6R, IL6
10
Show member pathways
thioredoxin pathway36
9.5CRP, IL6
119.4IL9, IL6
129.4IL9, IL6
13
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.1CRP, CR2
149.1CRP, IL6R, IL6
15
Show member pathways
Type III interferon signaling36
9.0IL6, IL9, IL6R
16
Show member pathways
9.0IL6, IL9, IL6R
17
Show member pathways
9.0IL6, IL9, IL6R
18
Show member pathways
9.0IL6, IL9, IL6R
19
Show member pathways
9.0IL6R, IL9, IL6
20
Show member pathways
8.9IL6, IL9, CRP
218.8CR2, IL6R, IL6
22
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.6IL6, IL9, CR2

Compounds for genes affiliated with Castleman's Disease

About this section

Compounds related to Castleman's Disease according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1turpentine4410.0IL6, CRP
2iron sucrose4410.0CRP, IL6
3cdp5714410.0CRP, IL6
4bucillamine4410.0CRP, IL6
5tenidap44 2811.0IL6, CRP
6anakinra44 1111.0IL6, CRP
7gabexate mesilate4410.0CRP, IL6
8pamidronate44 50 1111.9CRP, IL6
9il 10449.9IL6R, IL6
10adalimumab44 50 1111.9CRP, IL6
11pmma449.9CRP, IL6
12rosuvastatin44 50 28 1112.9IL6, CRP
138-isoprostane449.9CRP, IL6
14etanercept44 50 1111.9IL6, CRP
15deoxypyridinoline449.9IL6R, CRP
16ifn-alpha449.9IL6R, IL6
17infliximab44 50 1111.8IL6, CRP
18fenofibrate44 50 1111.8IL6, CRP
19ivig449.8CRP, IL6
20fluvastatin44 50 28 1112.8CRP, IL6
21methylcellulose449.8IL9, IL6
22pioglitazone28 44 50 1112.7CRP, IL6
23thalidomide44 50 60 1112.7IL6, IL6R
24methacholine44 50 1111.6IL9, CRP
25gp 130449.6IL6R, IL6
26pravastatin44 50 28 24 1113.6CRP, IL6
27rosiglitazone28 44 50 24 1113.5IL6, CRP
28tocilizumab44 1110.5CRP, IL6, IL6R
29neopterin449.5IL6, CRP, IL6R
30rituximab44 50 1111.5IL6R, CRP, IL6
31prednisolone44 28 1111.5IL6, IL6R, CRP
32methotrexate50 44 1111.5IL6, CRP, IL6R
33fibrinogen449.5IL6R, IL6, CRP
34creatinine449.4IL6, CRP, IL6R
35rantes449.4IL9, IL6R, IL6
36histamine44 28 2411.4IL6, IL9, IL6R
37thymidine44 2410.3IL6, IL9, IL6R
38testosterone44 60 24 1112.3IL6, CRP, IL6R
39atorvastatin44 50 28 24 1113.2CRP, IL6
40cholesterol44 28 24 1112.2IL6, CRP, IL6R
41okt3449.2CRP, CR2, IL6
42cyclosporin a44 28 6011.1IL6, IL6R, CR2
43vegf449.0IL6R, IL6, CRP
44lipid448.8IL6, IL9, CRP, IL6R
45cycloheximide448.7IL6, CR2, CRP, IL6R
46tyrosine448.4IL6, IL9, IL6R, CR2

GO Terms for genes affiliated with Castleman's Disease

About this section

Cellular components related to Castleman's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:00058969.3IL6R, IL6
2extracellular spaceGO:00056158.5CRP, IL6R, IL9, IL6

Biological processes related to Castleman's Disease according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:000238410.0IL6, IL6R
2negative regulation of collagen biosynthetic processGO:00329669.9IL6R, IL6
3neutrophil mediated immunityGO:00024469.9IL6R, IL6
4interleukin-6-mediated signaling pathwayGO:00701029.9IL6R, IL6
5positive regulation of leukocyte chemotaxisGO:00026909.9IL6R, IL6
6positive regulation of chemokine productionGO:00327229.9IL6, IL6R
7monocyte chemotaxisGO:00025489.9IL6R, IL6
8defense response to Gram-negative bacteriumGO:00508299.9IL6R, IL6
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, IL6R
10negative regulation of lipid storageGO:00108889.9IL6, CRP
11positive regulation of interleukin-6 productionGO:00327559.8IL6, IL6R
12endocrine pancreas developmentGO:00310189.8IL6, IL6R
13positive regulation of smooth muscle cell proliferationGO:00486619.8IL6R, IL6
14positive regulation of osteoblast differentiationGO:00456699.7IL6R, IL6
15positive regulation of MAPK cascadeGO:00434109.6IL6, IL6R
16positive regulation of NF-kappaB transcription factor activityGO:00510929.6IL6R, IL6
17positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5IL6R, IL6
18defense response to Gram-positive bacteriumGO:00508309.4CRP, IL6R, IL6
19acute-phase responseGO:00069539.4CRP, IL6R, IL6
20agingGO:00075689.2CRP, IL6
21complement activation, classical pathwayGO:00069589.2CR2, CRP
22inflammatory responseGO:00069549.2CRP, IL9, IL6
23positive regulation of cell proliferationGO:00082849.1IL6, IL9, IL6R

Molecular functions related to Castleman's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00051389.3IL6R, IL6
2protein homodimerization activityGO:00428038.7CR2, CRP, IL6R

Sources for Castleman's Disease

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet