Castleman's Disease malady

Summaries for Castleman's Disease

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. while the cause of castleman's disease is unknown, many doctors suspect a virus is involved. problems with the way an individual's immune system functions may also contribute to the development of the condition. there are 2 main forms of castleman's disease: localized (discussed here) and multicentric. they affect people very differently. localized or unicentric castleman's disease only affects a single set of lymph nodes and is not widespread. the lymph nodes that are more commonly affected are in the chest and abdomen. castleman’s disease causes the lymph nodes to get larger. the enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. people with localized castleman's disease are often cured when the lymph node is removed with surgery. chemotherapy and radiation may also be used. last updated: 4/25/2012

MalaCards: Castleman's Disease, also known as angiofollicular ganglionic hyperplasia, is related to sarcoma and poems syndrome. An important gene associated with Castleman's Disease is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are IL6-mediated signaling events and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Castleman's Disease

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60UMLS, 42NIH Rare Diseases, 44Novoseek
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Aliases & Descriptions:

castleman's disease 42
angiofollicular ganglionic hyperplasia 60
angiolymphoid hyperplasia 60
castleman disease 44

Related Diseases for Castleman's Disease

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17GeneCards, 18GeneDecks
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Diseases in the Castleman's Disease family:

Localized Castleman Disease

Diseases related to Castleman's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.9EVPL, HSPA4, F8, PPL, CR2, CD99
2poems syndrome30.5IL6
3pemphigus30.5EVPL, DSG3, PPL
4kaposi's sarcoma30.4F8, IL6
5vascular disease30.4HSPA4, F8, IL10, IL6, F3
7atherosclerosis30.1HSPA4, CCL4, CRP, IL10, IL6, IL6R
8follicular dendritic cell sarcoma30.1PPL
9pancreatitis30.1CRP, IL10, IL6
10deficiency anemia30.1CRP, EPO, IL6, F3
11arthritis30.1CCL4, CRP, IL10, IL6, IL6R
12rheumatoid arthritis30.1CCL4, CRP, IL10, IL6, IL6R
13skin disease30.1HSPA4, DSG3, IL10, IL5
14non-hodgkin lymphoma30.1HSPA4, CR2, IL9, IL6R, ABCB1, FSCN1
15lupus erythematosus29.9F3
16lichen planus29.9DSG3
17myasthenia gravis29.9IL10
20multiple myeloma29.9IL6R, IL6
22uveitis29.9IL9, IL10, CCL4
23acute leukemia29.8EPO, IL9, IL6R, ABCB1
24myeloma29.8CCL4, EPO, IL6, IL6R, ABCB1
25hodgkin's lymphoma29.8FSCN1, IL6R, IL9, HSPA4
26coronary artery disease29.8F3, IL6, CRP, HSPA4
27pneumonia29.8IL6, IL5, IL10, CRP, HSPA4
28systemic lupus erythematosus29.8CCL4, F8, CR2, CRP, IL10, IL6
29leukemia29.8HSPA4, CCL4, F8, CR2, CD99, EPO
31angiofollicular ganglionic hyperplasia10.5
32histiocytoid hemangioma10.5
33kimura disease10.4
34multicentric castleman’s disease10.4
35follicular mucinosis10.4
36temporal arteritis10.3
37nephrotic syndrome10.2
39arteriovenous malformation10.1
40latent syphilis10.1
41hemangioma of orbit10.1
43eyelid disease10.1
44orbital disease10.1
47iron deficiency anemia10.1
48autoimmune hemolytic anemia10.1
49dendritic cell sarcoma10.1
50hemolytic anemia10.1

Graphical network of the top 20 diseases related to Castleman's Disease:

Diseases related to castleman's disease

Clinical Features for Castleman's Disease

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Drugs & Therapeutics for Castleman's Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Castleman's Disease

Drug clinical trials:

Search ClinicalTrials for Castleman's Disease

Search NIH Clinical Center for Castleman's Disease

Search CenterWatch for Castleman's Disease

Genetic Tests for Castleman's Disease

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Anatomical Context for Castleman's Disease

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MalaCards organs/tissues related to Castleman's Disease:

Lymph node

Animal Models for Castleman's Disease or affiliated genes

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MGI Mouse Phenotypes related to Castleman's Disease:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.7ABCB1, IL6R, IL6, IL5, IL10, EPO
2MP:00053769.4F8, CR2, CRP, IL5, IL9
3MP:00053978.9EPO, DSG3, CR2, F8, IL10, IL5
4MP:00053878.7FSCN1, F8, CR2, CRP, DSG3, IL10

Publications for Castleman's Disease

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Genetic Variations for Castleman's Disease

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Expression for genes affiliated with Castleman's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Castleman's Disease

Search GEO for disease gene expression data for Castleman's Disease.

Pathways for genes affiliated with Castleman's Disease

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37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 29KEGG
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Pathways related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CRP, IL6, IL6R
210.1IL6, IL9, IL5
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10.1IL6R, IL9, IL5
410.0IL10, IL5, IL9
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10.0F3, CR2, F8
69.9IL10, IL5, IL9, IL6
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9.9CCL4, IL5, IL9, IL6R
89.9IL6R, IL6, IL10, MIR210
99.8CR2, EPO, IL5, IL6, IL6R
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9.7CR2, IL10, IL5, IL9, IL6
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9.7IL6, IL9, IL5, IL10, HSPA4
129.6IL6R, IL6, IL9, IL5, IL10, EPO
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9.6CCL4, IL10, IL5, IL9, IL6, IL6R
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9.6CCL4, IL10, IL5, IL9, IL6, IL6R

Compounds for genes affiliated with Castleman's Disease

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Castleman's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.7IL10
2hydrocortisone44 2 59 1113.7EPO
3endotoxin4410.6F3, F8
4ketamine44 28 1112.5CRP, HSPA4
5tocilizumab44 1111.5IL6, IL6R, CRP
6cyclosporin a44 28 5912.5CR2, IL6R, F8
7iron sucrose4410.5CRP, IL6, EPO
8cdp5714410.5IL6, IL10, CRP
9aprotinin44 1111.3EPO, F3
10tranexamic acid44 1111.3F8, EPO, F3
11tacrolimus44 49 1112.3ABCB1, IL5, CCL4
12mcp 14410.3IL6, CCL4, IL10, IL5
13okt34410.3CRP, IL6, IL10, CR2
14amphotericin b4410.3CCL4
15rantes4410.3IL6, IL6R, IL9, CCL4
16methylcellulose4410.3IL6, IL5, IL9, EPO
17azithromycin44 1111.3ABCB1, IL10, CRP
18mip 1alpha4410.3IL10, CCL4, IL6
19pamidronate44 49 1112.3CRP, IL6, IL10
20rituximab44 49 1112.2CRP, F8, IL6R, IL6, IL10
21neopterin4410.2IL6R, CRP, IL6, IL10
22thalidomide44 49 59 1113.2IL5, IL6, IL6R, IL10, EPO
23il 104410.2IL6R, IL6, IL5, IL10, CCL4
24tarc4410.2IL10, IL5, CCL4, IL9
25melphalan44 1111.1HSPA4, ABCB1, IL6, EPO
26aspartate4410.1HSPA4, F8
27theophylline44 28 11 2413.1IL5, CRP, IL10, EPO
28cyclophosphamide44 49 1112.1ABCB1, F3, F8, CRP, IL10
29allergens4410.1CCL4, IL5, IL9, IL10
30simvastatin44 49 59 28 11 2415.0ABCB1, CCL4, IL10, IL6, F3, CRP
31dexamethasone44 49 28 1113.0F8, IL6, IL6R, ABCB1, IL5, HSPA4
32fibrinogen4410.0F3, HSPA4, F8, CRP, IL6, IL6R
33histamine44 28 2412.0IL6, CCL4, IL6R, IL5, IL9, IL10
34methotrexate44 49 1112.0IL6R, ABCB1, CRP, IL5, EPO, IL6
35ibuprofen44 28 49 11 2414.0HSPA4, ABCB1, F3, IL6, CCL4, IL10
36zidovudine44 1111.0F3, IL10, EPO, ABCB1
37ly294002449.9IL6, IL5, IL10, EPO, CRP, HSPA4
38ivig449.9IL6, IL5, CRP, IL10, DSG3, F8
39sb 20358044 5910.8CCL4, HSPA4, F3, CRP, IL6, IL5
40creatinine449.8EPO, CRP, IL6R, F3, F8, CCL4
41testosterone44 59 11 2412.8HSPA4, CRP, EPO, IL5, IL6, IL6R
42adalimumab44 49 1111.8IL6, CRP, IL10
43cholesterol44 28 11 2412.7F8, IL6R, IL6, CRP, ABCB1, CCL4
44serine449.7CCL4, DSG3, F8, FSCN1, IL9
45paraffin449.7IL10, FSCN1, CD99, CR2, IL5, HSPA4
46prednisolone44 28 1111.6IL10, IL5, CRP, F8, DSG3, CCL4
47thymidine44 2410.5IL5, IL6R, IL6, EPO, IL10, IL9
48retinoic acid44 2410.4F3, KRT15, HSPA4, CCL4, IL5, IL9
49vegf449.2CRP, HSPA4, CCL4, F8, EPO, CD99
50tyrosine449.1KRT15, F8, IL5, DSG3, EPO, CR2

GO Terms for genes affiliated with Castleman's Disease

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16Gene Ontology
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Cellular components related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:0058969.9IL6R, IL6
2desmosomeGO:0300579.8PPL, DSG3, EVPL
3extracellular regionGO:0055769.5F8, CRP, EPO, IL5, IL6, IL6R
4extracellular spaceGO:0056159.1F3, CCL4, F8, CRP, EPO, IL10

Biological processes related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.5IL6, IL6R
2negative regulation of collagen biosynthetic processGO:03296610.5IL6, IL6R
3neutrophil mediated immunityGO:00244610.4IL6R, IL6
4positive regulation of immunoglobulin secretionGO:05102410.4IL5, IL6
5negative regulation of lipid storageGO:01088810.4CRP, IL6
6defense response to Gram-positive bacteriumGO:05083010.3CRP, IL6, IL6R
7interleukin-6-mediated signaling pathwayGO:07010210.3IL6R, IL6
8acute-phase responseGO:00695310.3IL6R, IL6, CRP, F8
9positive regulation of JAK-STAT cascadeGO:04642710.2IL6, IL5
10positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2IL6R, IL6, IL5
11positive regulation of leukocyte chemotaxisGO:00269010.1IL6R, IL6
12positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.1IL10, IL5, IL6
13inflammatory responseGO:0069549.9CCL4, CRP, IL10, IL5, IL9, IL6
14agingGO:0075689.8IL6, EPO, CRP

Molecular functions related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00513810.2IL6R, IL6
2cytokine activityGO:0051259.6IL6, IL9, IL5, IL10, CCL4
3growth factor activityGO:0080839.6IL10, IL5, IL9, IL6

Products for genes affiliated with Castleman's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Castleman's Disease

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26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet