MCID: CST002
MIFTS: 49

Castleman's Disease malady

Rare diseases, Immune diseases, Cancer diseases, Infectious diseases categories

Summaries for Castleman's Disease

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NIH Rare Diseases:43 Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. while the cause of castleman's disease is unknown, many doctors suspect a virus is involved. problems with the way an individual's immune system functions may also contribute to the development of the condition. there are 2 main forms of castleman's disease: localized (discussed here) and multicentric. they affect people very differently. localized or unicentric castleman's disease only affects a single set of lymph nodes and is not widespread. the lymph nodes that are more commonly affected are in the chest and abdomen. castleman’s disease causes the lymph nodes to get larger. the enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. people with localized castleman's disease are often cured when the lymph node is removed with surgery. chemotherapy and radiation may also be used. last updated: 4/25/2012

MalaCards based summary: Castleman's Disease, also known as angiofollicular ganglionic hyperplasia, is related to multicentric castleman’s disease and angiofollicular lymph hyperplasia. An important gene associated with Castleman's Disease is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are IL-6 Signaling Pathway and IL-17 Family Signaling Pathways. The compounds turpentine and iron sucrose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Castleman's Disease

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Castleman's Disease, Aliases & Descriptions:

Name: Castleman's Disease 43
Angiofollicular Ganglionic Hyperplasia 43 62
 
Angiofollicular Lymph Hyperplasia 43 62
Angiolymphoid Hyperplasia 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases, Infectious diseases
Anatomical: Immune diseases


Related Diseases for Castleman's Disease

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Diseases in the Castleman's Disease family:

Localized Castleman Disease

Diseases related to Castleman's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1multicentric castleman’s disease30.8IL6R, IL6
2angiofollicular lymph hyperplasia10.6
3classic kaposi sarcoma10.1IL6
4aortic aneurysm10.0CRP
5bacteriuria10.0CRP
6bronchitis10.0CRP
7crohn's disease10.0CRP
8systemic lupus erythematosus10.0CRP
9plasmacytoma10.0IL6, IL6R
10adult-onset still's disease10.0IL6, CRP
11viral meningitis10.0CRP, IL6
12chorioamnionitis10.0CRP, IL6
13pulmonary disease, chronic obstructive10.0CRP, IL6
14eye disease10.0IL6, CRP
15kaposi sarcoma10.0IL6, IL6R
16juvenile rheumatoid arthritis10.0CRP, IL6
17respiratory failure10.0IL6, CRP
18thrombocytosis10.0IL6, CRP
19meningitis10.0CRP, IL6
20leukopenia10.0CRP, IL6
21peritonitis10.0IL6, CRP
22synovitis10.0CRP, IL6
23acute pancreatitis10.0IL6, CRP
24periodontal disease10.0CRP, IL6
25rheumatic disease10.0IL6R, CRP
26lipid metabolism disorder10.0IL6, CRP
27multiple myeloma10.0IL6R, IL6
28colitis10.0IL6, IL6R
29pancreatitis10.0IL6, CRP
30liver disease10.0IL6, CRP
31congenital heart disease10.0CRP, IL6
32coronary artery disease10.0IL6, CRP
33ulcerative colitis10.0IL6, CRP, IL6R
34inflammatory bowel disease10.0CRP, IL6R, IL6
35endometriosis10.0IL6R, IL6
36osteoarthritis10.0IL6R, IL6, CRP
37diabetes mellitus, noninsulin-dependent10.0IL6R, CRP, IL6
38arthritis10.0IL6, IL6R, CRP
39obesity10.0IL6R, CRP, IL6
40atherosclerosis10.0CRP, IL6R, IL6
41multiple sclerosis, disease progression, modifier of10.0IL6R, IL9, IL6
42rheumatoid arthritis10.0IL6R, IL6, CRP
43burkitt lymphoma10.0IL6R, CR2
44allergic asthma10.0IL9, CR2
45hodgkin lymphoma10.0IL6R, IL9
46ipex syndrome10.0IL6, IL6R, CR2
47lymphoma, non-hodgkin10.0IL6R, IL9, CR2
48hypersensitivity reaction type ii disease9.9IL6, IL9, IL6R, CR2, EVPL
49leukemia9.9CR2, EVPL, IL9, IL6, IL6R

Graphical network of the top 20 diseases related to Castleman's Disease:



Diseases related to castleman's disease

Symptoms for Castleman's Disease

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Drugs & Therapeutics for Castleman's Disease

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Drug clinical trials:

Search ClinicalTrials for Castleman's Disease

Search NIH Clinical Center for Castleman's Disease

Genetic Tests for Castleman's Disease

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Anatomical Context for Castleman's Disease

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MalaCards organs/tissues related to Castleman's Disease:

33
Lymph node, B cells, Lung, Kidney, T cells, Endothelial, Liver, Skin, Spleen, Pancreas, Breast, Heart, Colon, Adrenal gland, Ovary, Monocytes, Tongue

Animal Models for Castleman's Disease or affiliated genes

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MGI Mouse Phenotypes related to Castleman's Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CR2, IL6R, IL9, IL6
2MP:00053877.5CR2, CRP, IL6R, IL9, IL6
3MP:00053767.3IL6, IL9, IL6R, CRP, CR2

Publications for Castleman's Disease

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Articles related to Castleman's Disease:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Durable remission with rituximab in a patient with an unusual variant of Castleman's disease with myelofibrosis -TAFRO syndrome. (25808231)
2015
2
Successful use of tocilizumab in a case of multicentric Castleman's disease and end-stage renal disease. (24571441)
2014
3
Clinical features and outcomes in patients with human immunodeficiency virus-negative, multicentric Castleman's disease: a single medical center experience. (25548759)
2014
4
Retroperitoneal unicentric Castleman's disease-a hyaline vascular challenge. (25118641)
2014
5
Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient. (25169666)
2014
6
Castleman's disease mimicked gynaecological adnexal tumour. (24831584)
2014
7
Reversal of cardiomyopathy with tocilizumab in a case of HIV-negative Castleman's disease. (23786462)
2013
8
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
9
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
10
The spectrum of Castleman's disease: mimics, radiologic pathologic correlation and role of imaging in patient management. (20643523)
2012
11
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease. (23102767)
2012
12
Castleman's Disease: A Case Report of the Unicentric Type. (22991681)
2012
13
The characterization and management of Castleman's disease. (22971511)
2012
14
Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report. (21577263)
2011
15
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
16
Retroperitoneal unicentric Castleman's disease with multiple lymph node involvement. (22696693)
2011
17
Solitary intra-abdominal Castleman's disease, hyaline vascular type: case report. (20164010)
2010
18
Highly active antiretroviral therapy alone may be an effective treatment for HIV-associated multi-centric Castleman's disease. (20801900)
2010
19
Castleman's disease of the parotid gland: a case report. (20705256)
2010
20
Castleman's disease in the head and neck region: Meta-analysis of reported cases in Taiwan and literature review. (21195890)
2010
21
Castleman's disease: a study of a rare lymphoproliferative disorder in a university hospital. (20164006)
2010
22
Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report. (20205844)
2010
23
Vinblastine, rituximab and HAART, treatment of an HIV -positive patient with multicentric Castleman's disease. (20167961)
2010
24
The analysis of interleukin-6 in patients with systemic IgG4-related plasmacytic syndrome--expansion of SIPS to the territory of Castleman's disease. (19447768)
2009
25
Splenectomy-induced long-term remission in a patient with multicentric Castleman's disease. (19767666)
2009
26
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
27
Castleman's disease: an intrapulmonary form with intrafissural development. (19768350)
2009
28
A rare case of Castleman's disease of plasma cell type within kidney. (20079147)
2009
29
Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection. (19298351)
2009
30
Hyaline vascular-type Castleman's disease of the retroperitoneum. (18677335)
2008
31
Multicentric Castleman's disease presenting with multiple nodes in lungs: a case report and literature review. (18815726)
2008
32
Unicentric Castleman's disease in peripancreatic tissue: case report and review of the literature. (18419976)
2008
33
FDG-PET and diffusion-weighted MR imaging appearance in retroperitoneal Castleman's disease: a case report. (18313580)
2008
34
Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease. (17541233)
2007
35
Castleman's disease of the axilla mimicking metastasis. (17996608)
2007
36
Castleman's disease and retroviral therapy. (17931977)
2007
37
Are multicentric Castleman's disease with cutaneous plasmacytosis and systemic plasmacytosis the same entity? (17064311)
2006
38
Interfollicular Hodgkin's lymphoma and Castleman's disease. (16430484)
2006
39
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
40
Castleman's disease as an unusual neck mass: case report. (15224829)
2004
41
Castleman's disease. (14585575)
2003
42
Hyaline vascular Castleman's disease: a case report and brief review of the literature. (12685494)
2002
43
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10702388)
2000
44
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
45
Castleman's disease. (10655569)
1999
46
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
47
Castleman's disease in a 44-year-old male with neurofibromatosis and pheochromocytoma. (9477139)
1997
48
A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects. (8695726)
1996
49
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
50
Angiofollicular lymph node hyperplasia (Castleman's disease) in an adolescent female. Clinical and immunologic findings. (1873789)
1991

Variations for Castleman's Disease

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Expression for genes affiliated with Castleman's Disease

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Search GEO for disease gene expression data for Castleman's Disease.

Pathways for genes affiliated with Castleman's Disease

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Pathways related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL6R, IL6
2
Show member pathways
9.6IL6, IL6R
3
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.6IL6R, IL6
49.6IL6R, IL6
5
Show member pathways
9.6IL6, IL6R
69.6IL6, IL6R
7
Show member pathways
9.6IL6, IL6R
8
Show member pathways
9.6IL6R, IL6
99.6IL6, IL6R
10
Show member pathways
thioredoxin pathway38
9.5CRP, IL6
119.4IL6, IL9
129.4IL9, IL6
13
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.1CR2, CRP
149.1IL6, IL6R, CRP
15
Show member pathways
Type III interferon signaling38
9.0IL6R, IL6, IL9
16
Show member pathways
9.0IL6R, IL6, IL9
17
Show member pathways
9.0IL6R, IL6, IL9
18
Show member pathways
9.0IL6R, IL6, IL9
19
Show member pathways
9.0IL6R, IL9, IL6
20
Show member pathways
8.9IL6, IL9, CRP
218.8CR2, IL6R, IL6
22
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.6IL6, IL9, CR2

Compounds for genes affiliated with Castleman's Disease

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Compounds related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1turpentine4510.0IL6, CRP
2iron sucrose4510.0CRP, IL6
3cdp5714510.0CRP, IL6
4bucillamine4510.0CRP, IL6
5tenidap45 3011.0IL6, CRP
6anakinra45 1311.0IL6, CRP
7gabexate mesilate4510.0CRP, IL6
8pamidronate45 51 1311.9CRP, IL6
9il 10459.9IL6R, IL6
10adalimumab45 51 1311.9CRP, IL6
11pmma459.9CRP, IL6
12rosuvastatin45 51 30 1312.9IL6, CRP
138-isoprostane459.9CRP, IL6
14etanercept45 51 1311.9IL6, CRP
15deoxypyridinoline459.9IL6R, CRP
16ifn-alpha459.9IL6R, IL6
17infliximab45 51 1311.8IL6, CRP
18fenofibrate45 51 1311.8IL6, CRP
19ivig459.8CRP, IL6
20fluvastatin45 51 30 1312.8CRP, IL6
21methylcellulose459.8IL9, IL6
22pioglitazone30 45 51 1312.7CRP, IL6
23thalidomide45 51 61 1312.7IL6, IL6R
24methacholine45 51 1311.6IL9, CRP
25gp 130459.6IL6R, IL6
26pravastatin45 51 30 26 1313.6CRP, IL6
27rosiglitazone30 45 51 26 1313.5IL6, CRP
28tocilizumab45 1310.5CRP, IL6, IL6R
29neopterin459.5IL6, CRP, IL6R
30rituximab45 51 1311.5IL6R, CRP, IL6
31prednisolone45 30 1311.5IL6, IL6R, CRP
32methotrexate51 45 1311.5IL6, CRP, IL6R
33fibrinogen459.5IL6R, IL6, CRP
34creatinine459.4IL6, CRP, IL6R
35rantes459.4IL9, IL6R, IL6
36histamine45 30 2611.4IL6, IL9, IL6R
37thymidine45 2610.3IL6, IL9, IL6R
38testosterone45 61 26 1312.3IL6, CRP, IL6R
39atorvastatin45 51 30 26 1313.2CRP, IL6
40cholesterol45 30 26 1312.2IL6, CRP, IL6R
41okt3459.2CRP, CR2, IL6
42cyclosporin a45 30 6111.1IL6, IL6R, CR2
43vegf459.0IL6R, IL6, CRP
44lipid458.8IL6, IL9, CRP, IL6R
45cycloheximide458.7IL6, CR2, CRP, IL6R
46tyrosine458.4IL6, IL9, IL6R, CR2

GO Terms for genes affiliated with Castleman's Disease

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Cellular components related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:00058969.3IL6R, IL6
2extracellular spaceGO:00056158.5CRP, IL6R, IL9, IL6

Biological processes related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:000238410.0IL6, IL6R
2negative regulation of collagen biosynthetic processGO:00329669.9IL6R, IL6
3neutrophil mediated immunityGO:00024469.9IL6R, IL6
4interleukin-6-mediated signaling pathwayGO:00701029.9IL6R, IL6
5positive regulation of leukocyte chemotaxisGO:00026909.9IL6R, IL6
6positive regulation of chemokine productionGO:00327229.9IL6, IL6R
7monocyte chemotaxisGO:00025489.9IL6R, IL6
8defense response to Gram-negative bacteriumGO:00508299.9IL6R, IL6
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, IL6R
10negative regulation of lipid storageGO:00108889.9IL6, CRP
11positive regulation of interleukin-6 productionGO:00327559.8IL6, IL6R
12endocrine pancreas developmentGO:00310189.8IL6, IL6R
13positive regulation of smooth muscle cell proliferationGO:00486619.8IL6R, IL6
14positive regulation of osteoblast differentiationGO:00456699.7IL6R, IL6
15positive regulation of MAPK cascadeGO:00434109.6IL6, IL6R
16positive regulation of NF-kappaB transcription factor activityGO:00510929.6IL6R, IL6
17positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5IL6R, IL6
18defense response to Gram-positive bacteriumGO:00508309.4CRP, IL6R, IL6
19acute-phase responseGO:00069539.4CRP, IL6R, IL6
20agingGO:00075689.2CRP, IL6
21complement activation, classical pathwayGO:00069589.2CR2, CRP
22inflammatory responseGO:00069549.2CRP, IL9, IL6
23positive regulation of cell proliferationGO:00082849.1IL6, IL9, IL6R

Molecular functions related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00051389.3IL6R, IL6
2protein homodimerization activityGO:00428038.7CR2, CRP, IL6R

Products for genes affiliated with Castleman's Disease

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Sources for Castleman's Disease

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