MCID: CST002
MIFTS: 42

Castleman's Disease malady

Rare diseases, Immune diseases, Cancer diseases, Infectious diseases categories

Aliases & Classifications for Castleman's Disease

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Castleman's Disease, Aliases & Descriptions:

Name: Castleman's Disease 41
Angiofollicular Ganglionic Hyperplasia 41 60
 
Angiofollicular Lymph Hyperplasia 41
Angiolymphoid Hyperplasia 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases, Infectious diseases
Anatomical: Immune diseases


Summaries for Castleman's Disease

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NIH Rare Diseases:41 Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. while the cause of castleman's disease is unknown, many doctors suspect a virus is involved. problems with the way an individual's immune system functions may also contribute to the development of the condition. there are 2 main forms of castleman's disease: localized (discussed here) and multicentric. they affect people very differently. localized or unicentric castleman's disease only affects a single set of lymph nodes and is not widespread. the lymph nodes that are more commonly affected are in the chest and abdomen. castleman’s disease causes the lymph nodes to get larger. the enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. people with localized castleman's disease are often cured when the lymph node is removed with surgery. chemotherapy and radiation may also be used. last updated: 4/25/2012

MalaCards based summary: Castleman's Disease, also known as angiofollicular ganglionic hyperplasia, is related to multicentric castleman’s disease and angiofollicular lymph hyperplasia. An important gene associated with Castleman's Disease is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Transcription Androgen Receptor nuclear signaling and IL-17 Family Signaling Pathways. The compounds turpentine and iron sucrose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and lung, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Castleman's Disease

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Diseases in the Castleman's Disease family:

Localized Castleman Disease

Diseases related to Castleman's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1multicentric castleman’s disease31.1IL6R, IL6
2angiofollicular lymph hyperplasia10.6
3classic kaposi sarcoma10.4IL6
4aortic aneurysm10.4CRP
5bronchitis10.4CRP
6bacteriuria10.4CRP
7crohn's disease10.4CRP
8systemic lupus erythematosus10.3CRP
9plasmacytoma10.3IL6R, IL6
10adult-onset still's disease10.3CRP, IL6
11viral meningitis10.2CRP, IL6
12chorioamnionitis10.2IL6, CRP
13pulmonary disease, chronic obstructive10.2CRP, IL6
14eye disease10.2IL6, CRP
15kaposi sarcoma10.2IL6R, IL6
16juvenile rheumatoid arthritis10.2CRP, IL6
17respiratory failure10.2CRP, IL6
18thrombocytosis10.2IL6, CRP
19meningitis10.2IL6, CRP
20leukopenia10.2IL6, CRP
21peritonitis10.2IL6, CRP
22nutritional deficiency disease10.2IL6, CRP
23synovitis10.2CRP, IL6
24acute pancreatitis10.2CRP, IL6
25periodontal disease10.2IL6, CRP
26rheumatic disease10.2IL6R, CRP
27lipid metabolism disorder10.2IL6, CRP
28multiple myeloma10.2IL6R, IL6
29colitis10.2IL6, IL6R
30pancreatitis10.2IL6, CRP
31liver disease10.1CRP, IL6
32congenital heart disease10.1IL6, CRP
33coronary artery disease10.1CRP, IL6
34ulcerative colitis10.0IL6, IL6R, CRP
35inflammatory bowel disease10.0CRP, IL6R, IL6
36endometriosis10.0IL6, IL6R
37osteoarthritis10.0IL6, IL6R, CRP
38diabetes mellitus, noninsulin-dependent10.0CRP, IL6R, IL6
39arthritis10.0CRP, IL6R, IL6
40obesity10.0CRP, IL6R, IL6
41multiple sclerosis, disease progression, modifier of10.0IL6R, IL9, IL6
42atherosclerosis10.0IL6, IL6R, CRP
43rheumatoid arthritis10.0CRP, IL6R, IL6
44burkitt lymphoma9.9CR2, IL6R
45allergic asthma9.9CR2, IL9
46hodgkin lymphoma9.9IL6R, IL9
47ipex syndrome9.8CR2, IL6R, IL6
48lymphoma, non-hodgkin9.8CR2, IL6R, IL9
49hypersensitivity reaction type ii disease9.4EVPL, CR2, IL6R, IL9, IL6
50leukemia9.4IL6, IL9, IL6R, CR2, EVPL

Graphical network of the top 20 diseases related to Castleman's Disease:



Diseases related to castleman's disease

Symptoms for Castleman's Disease

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Drugs & Therapeutics for Castleman's Disease

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Drug clinical trials:

Search ClinicalTrials for Castleman's Disease

Search NIH Clinical Center for Castleman's Disease

Genetic Tests for Castleman's Disease

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Anatomical Context for Castleman's Disease

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MalaCards organs/tissues related to Castleman's Disease:

31
Lymph node, B cells, Lung, Kidney, T cells, Endothelial, Liver, Skin, Spleen, Pancreas, Breast, Heart, Colon, Adrenal gland, Ovary, Monocytes, Tongue

Animal Models for Castleman's Disease or affiliated genes

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MGI Mouse Phenotypes related to Castleman's Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CR2, IL6R, IL9, IL6
2MP:00053877.5CR2, CRP, IL6R, IL9, IL6
3MP:00053767.3IL6, IL9, IL6R, CRP, CR2

Publications for Castleman's Disease

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Articles related to Castleman's Disease:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Durable remission with rituximab in a patient with an unusual variant of Castleman's disease with myelofibrosis -TAFRO syndrome. (25808231)
2015
2
Successful use of tocilizumab in a case of multicentric Castleman's disease and end-stage renal disease. (24571441)
2014
3
Clinical features and outcomes in patients with human immunodeficiency virus-negative, multicentric Castleman's disease: a single medical center experience. (25548759)
2014
4
Retroperitoneal unicentric Castleman's disease-a hyaline vascular challenge. (25118641)
2014
5
Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient. (25169666)
2014
6
Castleman's disease mimicked gynaecological adnexal tumour. (24831584)
2014
7
Reversal of cardiomyopathy with tocilizumab in a case of HIV-negative Castleman's disease. (23786462)
2013
8
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
9
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
10
The spectrum of Castleman's disease: mimics, radiologic pathologic correlation and role of imaging in patient management. (20643523)
2012
11
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease. (23102767)
2012
12
Castleman's Disease: A Case Report of the Unicentric Type. (22991681)
2012
13
The characterization and management of Castleman's disease. (22971511)
2012
14
Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report. (21577263)
2011
15
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
16
Retroperitoneal unicentric Castleman's disease with multiple lymph node involvement. (22696693)
2011
17
Solitary intra-abdominal Castleman's disease, hyaline vascular type: case report. (20164010)
2010
18
Highly active antiretroviral therapy alone may be an effective treatment for HIV-associated multi-centric Castleman's disease. (20801900)
2010
19
Castleman's disease of the parotid gland: a case report. (20705256)
2010
20
Castleman's disease in the head and neck region: Meta-analysis of reported cases in Taiwan and literature review. (21195890)
2010
21
Castleman's disease: a study of a rare lymphoproliferative disorder in a university hospital. (20164006)
2010
22
Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report. (20205844)
2010
23
Vinblastine, rituximab and HAART, treatment of an HIV -positive patient with multicentric Castleman's disease. (20167961)
2010
24
The analysis of interleukin-6 in patients with systemic IgG4-related plasmacytic syndrome--expansion of SIPS to the territory of Castleman's disease. (19447768)
2009
25
Splenectomy-induced long-term remission in a patient with multicentric Castleman's disease. (19767666)
2009
26
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
27
Castleman's disease: an intrapulmonary form with intrafissural development. (19768350)
2009
28
A rare case of Castleman's disease of plasma cell type within kidney. (20079147)
2009
29
Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection. (19298351)
2009
30
Hyaline vascular-type Castleman's disease of the retroperitoneum. (18677335)
2008
31
Multicentric Castleman's disease presenting with multiple nodes in lungs: a case report and literature review. (18815726)
2008
32
Unicentric Castleman's disease in peripancreatic tissue: case report and review of the literature. (18419976)
2008
33
FDG-PET and diffusion-weighted MR imaging appearance in retroperitoneal Castleman's disease: a case report. (18313580)
2008
34
Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease. (17541233)
2007
35
Castleman's disease of the axilla mimicking metastasis. (17996608)
2007
36
Castleman's disease and retroviral therapy. (17931977)
2007
37
Are multicentric Castleman's disease with cutaneous plasmacytosis and systemic plasmacytosis the same entity? (17064311)
2006
38
Interfollicular Hodgkin's lymphoma and Castleman's disease. (16430484)
2006
39
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
40
Castleman's disease as an unusual neck mass: case report. (15224829)
2004
41
Castleman's disease. (14585575)
2003
42
Hyaline vascular Castleman's disease: a case report and brief review of the literature. (12685494)
2002
43
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10702388)
2000
44
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
45
Castleman's disease. (10655569)
1999
46
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
47
Castleman's disease in a 44-year-old male with neurofibromatosis and pheochromocytoma. (9477139)
1997
48
A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects. (8695726)
1996
49
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
50
Angiofollicular lymph node hyperplasia (Castleman's disease) in an adolescent female. Clinical and immunologic findings. (1873789)
1991

Variations for Castleman's Disease

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Expression for genes affiliated with Castleman's Disease

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Search GEO for disease gene expression data for Castleman's Disease.

Pathways for genes affiliated with Castleman's Disease

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Pathways related to Castleman's Disease according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.6IL6R, IL6
2
Show member pathways
9.6IL6R, IL6
39.6IL6R, IL6
49.6IL6, IL6R
5
Show member pathways
9.6IL6R, IL6
69.6IL6R, IL6
7
Show member pathways
9.6IL6R, IL6
8
Show member pathways
9.6IL6R, IL6
99.6IL6R, IL6
10
Show member pathways
thioredoxin pathway36
9.5CRP, IL6
119.4IL9, IL6
129.4IL9, IL6
13
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.1CRP, CR2
149.1CRP, IL6R, IL6
15
Show member pathways
Type III interferon signaling36
9.0IL6, IL9, IL6R
16
Show member pathways
9.0IL6, IL9, IL6R
17
Show member pathways
9.0IL6, IL9, IL6R
18
Show member pathways
9.0IL6, IL9, IL6R
19
Show member pathways
9.0IL6R, IL9, IL6
20
Show member pathways
8.9IL6, IL9, CRP
218.8CR2, IL6R, IL6
22
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.6IL6, IL9, CR2

Compounds for genes affiliated with Castleman's Disease

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Compounds related to Castleman's Disease according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1turpentine4310.0CRP, IL6
2iron sucrose4310.0IL6, CRP
3cdp5714310.0CRP, IL6
4bucillamine4310.0CRP, IL6
5tenidap43 2811.0IL6, CRP
6anakinra43 1211.0CRP, IL6
7gabexate mesilate4310.0CRP, IL6
8pamidronate43 49 1211.9CRP, IL6
9il 10439.9IL6R, IL6
10adalimumab43 49 1211.9IL6, CRP
11pmma439.9IL6, CRP
12rosuvastatin43 49 28 1212.9CRP, IL6
138-isoprostane439.9CRP, IL6
14etanercept43 49 1211.9CRP, IL6
15deoxypyridinoline439.9CRP, IL6R
16ifn-alpha439.9IL6, IL6R
17infliximab43 49 1211.8IL6, CRP
18fenofibrate43 49 1211.8CRP, IL6
19ivig439.8CRP, IL6
20fluvastatin43 49 28 1212.8CRP, IL6
21methylcellulose439.8IL9, IL6
22pioglitazone28 43 49 1212.7CRP, IL6
23thalidomide43 49 59 1212.7IL6R, IL6
24methacholine43 49 1211.6CRP, IL9
25gp 130439.6IL6R, IL6
26pravastatin43 49 28 24 1213.6CRP, IL6
27rosiglitazone28 43 49 24 1213.5CRP, IL6
28tocilizumab43 1210.5CRP, IL6R, IL6
29neopterin439.5IL6, IL6R, CRP
30rituximab43 49 1211.5CRP, IL6R, IL6
31prednisolone43 28 1211.5CRP, IL6R, IL6
32methotrexate49 43 1211.5IL6, IL6R, CRP
33fibrinogen439.5CRP, IL6R, IL6
34creatinine439.4CRP, IL6R, IL6
35rantes439.4IL6R, IL9, IL6
36histamine43 28 2411.4IL6, IL9, IL6R
37thymidine43 2410.3IL6, IL9, IL6R
38testosterone43 59 24 1212.3CRP, IL6R, IL6
39atorvastatin43 49 28 24 1213.2CRP, IL6
40cholesterol43 28 24 1212.2IL6, IL6R, CRP
41okt3439.2CR2, CRP, IL6
42cyclosporin a43 28 5911.1IL6, IL6R, CR2
43vegf439.0IL6, IL6R, CRP
44lipid438.8IL6, IL9, IL6R, CRP
45cycloheximide438.7IL6, IL6R, CRP, CR2
46tyrosine438.4IL6, IL9, IL6R, CR2

GO Terms for genes affiliated with Castleman's Disease

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Cellular components related to Castleman's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:00058969.3IL6R, IL6
2extracellular spaceGO:00056158.5CRP, IL6R, IL9, IL6

Biological processes related to Castleman's Disease according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:000238410.0IL6, IL6R
2negative regulation of collagen biosynthetic processGO:00329669.9IL6R, IL6
3neutrophil mediated immunityGO:00024469.9IL6R, IL6
4interleukin-6-mediated signaling pathwayGO:00701029.9IL6R, IL6
5positive regulation of leukocyte chemotaxisGO:00026909.9IL6R, IL6
6positive regulation of chemokine productionGO:00327229.9IL6, IL6R
7monocyte chemotaxisGO:00025489.9IL6R, IL6
8defense response to Gram-negative bacteriumGO:00508299.9IL6R, IL6
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, IL6R
10negative regulation of lipid storageGO:00108889.9IL6, CRP
11positive regulation of interleukin-6 productionGO:00327559.8IL6, IL6R
12endocrine pancreas developmentGO:00310189.8IL6, IL6R
13positive regulation of smooth muscle cell proliferationGO:00486619.8IL6R, IL6
14positive regulation of osteoblast differentiationGO:00456699.7IL6R, IL6
15positive regulation of MAPK cascadeGO:00434109.6IL6, IL6R
16positive regulation of NF-kappaB transcription factor activityGO:00510929.6IL6R, IL6
17positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5IL6R, IL6
18defense response to Gram-positive bacteriumGO:00508309.4CRP, IL6R, IL6
19acute-phase responseGO:00069539.4CRP, IL6R, IL6
20agingGO:00075689.2CRP, IL6
21complement activation, classical pathwayGO:00069589.2CR2, CRP
22inflammatory responseGO:00069549.2CRP, IL9, IL6
23positive regulation of cell proliferationGO:00082849.1IL6, IL9, IL6R

Molecular functions related to Castleman's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:00051389.3IL6R, IL6
2protein homodimerization activityGO:00428038.7CR2, CRP, IL6R

Products for genes affiliated with Castleman's Disease

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Sources for Castleman's Disease

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