MCID: CST002
MIFTS: 50

Castleman's Disease malady

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Summaries for Castleman's Disease

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. while the cause of castleman's disease is unknown, many doctors suspect a virus is involved. problems with the way an individual's immune system functions may also contribute to the development of the condition. there are 2 main forms of castleman's disease: localized (discussed here) and multicentric. they affect people very differently. localized or unicentric castleman's disease only affects a single set of lymph nodes and is not widespread. the lymph nodes that are more commonly affected are in the chest and abdomen. castleman’s disease causes the lymph nodes to get larger. the enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. people with localized castleman's disease are often cured when the lymph node is removed with surgery. chemotherapy and radiation may also be used. last updated: 4/25/2012

MalaCards: Castleman's Disease, also known as angiofollicular ganglionic hyperplasia, is related to kaposi's sarcoma and pancreatitis. An important gene associated with Castleman's Disease is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are IL-6 Signaling Pathway and IL-17 Family Signaling Pathways. The compounds turpentine and iron sucrose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Castleman's Disease

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43NIH Rare Diseases, 62UMLS, 45Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases, Infectious diseases
Anatomical: Immune diseases


Aliases & Descriptions:

castleman's disease 43
angiofollicular ganglionic hyperplasia 43 62
angiofollicular lymph hyperplasia 43
angiolymphoid hyperplasia 62
castleman disease 45


Related Diseases for Castleman's Disease

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17GeneCards, 18GeneDecks
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Diseases in the Castleman's Disease family:

Localized Castleman Disease

Diseases related to Castleman's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1kaposi's sarcoma30.5IL6R, IL6
2pancreatitis30.1IL6, CRP
3arthritis30.1CRP, IL6R, IL6
4rheumatoid arthritis30.1CRP, IL6R, IL6
5non-hodgkin lymphoma30.0CR2, IL6R, IL9
6systemic lupus erythematosus30.0CRP
7plasmacytoma30.0IL6R, IL6
8multiple myeloma29.9IL6R, IL6
9hodgkin's lymphoma29.8IL6R, IL9
10leukemia29.7IL6, IL9, IL6R, CR2, EVPL
11sarcoma10.6
12angiofollicular lymph hyperplasia10.5
13poems syndrome10.4
14multicentric castleman’s disease10.4
15pemphigus10.3
16localized castleman disease10.3
17paraneoplastic pemphigus10.3
18primary effusion lymphoma10.3
19nephrotic syndrome10.2
20aortic aneurysm10.1CRP
21bronchitis10.1CRP
22bacteriuria10.1CRP
23crohn's disease10.1CRP
24deficiency anemia10.1
25follicular dendritic cell sarcoma10.1
26iron deficiency anemia10.1
27autoimmune hemolytic anemia10.1
28dendritic cell sarcoma10.1
29hemolytic anemia10.1
30microcytic anemia10.1
31angioimmunoblastic t-cell lymphoma10.1
32autoimmune pancreatitis10.1
33follicular dendritic cell tumor10.1
34pediatric castleman disease10.1
35adult-onset still's disease10.1CRP, IL6
36viral meningitis10.1CRP, IL6
37chorioamnionitis10.1IL6, CRP
38pulmonary disease, chronic obstructive10.1CRP, IL6
39eye disease10.1IL6, CRP
40juvenile rheumatoid arthritis10.1CRP, IL6
41respiratory failure10.1CRP, IL6
42thrombocytosis10.0IL6, CRP
43meningitis10.0IL6, CRP
44leukopenia10.0IL6, CRP
45peritonitis10.0IL6, CRP
46synovitis10.0CRP, IL6
47acute pancreatitis10.0CRP, IL6
48periodontal disease10.0IL6, CRP
49rheumatic disease10.0IL6R, CRP
50galactosemia10.0CRP, IL6

Graphical network of the top 20 diseases related to Castleman's Disease:



Diseases related to castleman's disease

Symptoms for Castleman's Disease

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Drugs & Therapeutics for Castleman's Disease

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Castleman's Disease

Search NIH Clinical Center for Castleman's Disease

Genetic Tests for Castleman's Disease

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Anatomical Context for Castleman's Disease

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33MalaCards
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MalaCards organs/tissues related to Castleman's Disease:

33
Lymph node, B cells, Lung, Kidney, T cells, Endothelial, Liver, Skin, Breast, Pancreas, Ovary, Monocytes, Colon, Spleen, Tongue

Animal Models for Castleman's Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Castleman's Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CR2, IL6R, IL9, IL6
2MP:00053877.5CR2, CRP, IL6R, IL9, IL6
3MP:00053767.3IL6, IL9, IL6R, CRP, CR2

Publications for Castleman's Disease

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52PubMed
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Articles related to Castleman's Disease:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Reversal of cardiomyopathy with tocilizumab in a case of HIV-negative Castleman's disease. (23786462)
2013
2
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
3
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
4
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease. (23102767)
2012
5
Castleman's Disease: A Case Report of the Unicentric Type. (22991681)
2012
6
The characterization and management of Castleman's disease. (22971511)
2012
7
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
8
Retroperitoneal unicentric Castleman's disease with multiple lymph node involvement. (22696693)
2011
9
Solitary intra-abdominal Castleman's disease, hyaline vascular type: case report. (20164010)
2010
10
Highly active antiretroviral therapy alone may be an effective treatment for HIV-associated multi-centric Castleman's disease. (20801900)
2010
11
Castleman's disease of the parotid gland: a case report. (20705256)
2010
12
Castleman's disease in the head and neck region: Meta-analysis of reported cases in Taiwan and literature review. (21195890)
2010
13
Castleman's disease: a study of a rare lymphoproliferative disorder in a university hospital. (20164006)
2010
14
Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report. (20205844)
2010
15
Vinblastine, rituximab and HAART, treatment of an HIV -positive patient with multicentric Castleman's disease. (20167961)
2010
16
An unusual presentation of Castleman's disease. (20630032)
2010
17
A case of multicentric Castleman's disease having lung lesion successfully treated with humanized anti-interleukin-6 receptor antibody, tocilizumab. (20808682)
2010
18
The analysis of interleukin-6 in patients with systemic IgG4-related plasmacytic syndrome--expansion of SIPS to the territory of Castleman's disease. (19447768)
2009
19
Splenectomy-induced long-term remission in a patient with multicentric Castleman's disease. (19767666)
2009
20
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
21
Castleman's disease: an intrapulmonary form with intrafissural development. (19768350)
2009
22
A rare case of Castleman's disease of plasma cell type within kidney. (20079147)
2009
23
Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection. (19298351)
2009
24
A case of POEMS syndrome with mixed hyaline vascular and plasma cell type Castleman's disease. (19670555)
2009
25
Hyaline vascular-type Castleman's disease of the retroperitoneum. (18677335)
2008
26
Multicentric Castleman's disease presenting with multiple nodes in lungs: a case report and literature review. (18815726)
2008
27
Unicentric Castleman's disease in peripancreatic tissue: case report and review of the literature. (18419976)
2008
28
FDG-PET and diffusion-weighted MR imaging appearance in retroperitoneal Castleman's disease: a case report. (18313580)
2008
29
Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease. (17541233)
2007
30
Castleman's disease of the axilla mimicking metastasis. (17996608)
2007
31
Castleman's disease and retroviral therapy. (17931977)
2007
32
Are multicentric Castleman's disease with cutaneous plasmacytosis and systemic plasmacytosis the same entity? (17064311)
2006
33
Interfollicular Hodgkin's lymphoma and Castleman's disease. (16430484)
2006
34
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
35
Frequent detection of Kaposi's sarcoma herpesvirus in germinal centre macrophages from AIDS-related multicentric Castleman's disease. (15990578)
2005
36
Castleman's disease as an unusual neck mass: case report. (15224829)
2004
37
Castleman's disease of the lacrimal gland. (14746606)
2004
38
Remission of nephrotic syndrome after thalidomide therapy in a patient with Castleman's disease. (15182131)
2004
39
AIDS, multicentric Castleman's disease, and plasmablastic leukemia: report of a long-term survival. (15624895)
2004
40
Castleman's disease. (14585575)
2003
41
Hyaline vascular Castleman's disease: a case report and brief review of the literature. (12685494)
2002
42
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10702388)
2000
43
Increased expression of vascular endothelial growth factor (VEGF) in Castleman's disease: proposed pathomechanism of vascular proliferation in the affected lymph node. (10830746)
2000
44
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
45
Castleman's disease. (10655569)
1999
46
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
47
Castleman's disease in a 44-year-old male with neurofibromatosis and pheochromocytoma. (9477139)
1997
48
A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects. (8695726)
1996
49
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
50
Angiofollicular lymph node hyperplasia (Castleman's disease) in an adolescent female. Clinical and immunologic findings. (1873789)
1991

Variations for Castleman's Disease

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Expression for genes affiliated with Castleman's Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Castleman's Disease

Search GEO for disease gene expression data for Castleman's Disease.

Pathways for genes affiliated with Castleman's Disease

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50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 60Thomson Reuters, 30KEGG, 55Reactome, 53QIAGEN, 57SinoBiological
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Pathways related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL6R, IL6
2
Show member pathways
9.6IL6, IL6R
3
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.6IL6R, IL6
49.6IL6R, IL6
5
Show member pathways
9.6IL6, IL6R
69.6IL6, IL6R
7
Show member pathways
9.6IL6, IL6R
8
Show member pathways
9.6IL6R, IL6
99.6IL6, IL6R
10
Show member pathways
thioredoxin pathway38
9.5CRP, IL6
119.4IL6, IL9
129.4IL9, IL6
13
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.1CR2, CRP
149.1IL6, IL6R, CRP
15
Show member pathways
Type III interferon signaling38
9.0IL6R, IL6, IL9
16
Show member pathways
9.0IL6R, IL6, IL9
17
Show member pathways
9.0IL6R, IL6, IL9
18
Show member pathways
9.0IL6R, IL6, IL9
19
Show member pathways
9.0IL6R, IL9, IL6
20
Show member pathways
8.9IL6, IL9, CRP
218.8CR2, IL6R, IL6
22
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.6IL6, IL9, CR2

Compounds for genes affiliated with Castleman's Disease

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1turpentine4510.0CRP, IL6
2iron sucrose4510.0IL6, CRP
3cdp5714510.0CRP, IL6
4bucillamine4510.0CRP, IL6
5tenidap45 2911.0IL6, CRP
6anakinra45 1111.0CRP, IL6
7gabexate mesilate4510.0CRP, IL6
8pamidronate45 51 1111.9CRP, IL6
9il 10459.9IL6R, IL6
10adalimumab45 51 1111.9IL6, CRP
11pmma459.9IL6, CRP
12rosuvastatin45 51 29 1112.9CRP, IL6
138-isoprostane459.9CRP, IL6
14etanercept45 51 1111.9CRP, IL6
15deoxypyridinoline459.9CRP, IL6R
16ifn-alpha459.9IL6, IL6R
17infliximab45 51 1111.8IL6, CRP
18fenofibrate45 51 1111.8CRP, IL6
19ivig459.8CRP, IL6
20fluvastatin45 51 29 1112.8CRP, IL6
21methylcellulose459.8IL9, IL6
22pioglitazone29 45 51 1112.7CRP, IL6
23thalidomide45 51 61 1112.7IL6R, IL6
24methacholine45 51 1111.6CRP, IL9
25gp 130459.6IL6R, IL6
26pravastatin45 51 29 24 1113.6CRP, IL6
27rosiglitazone29 45 51 24 1113.5CRP, IL6
28tocilizumab45 1110.5CRP, IL6R, IL6
29neopterin459.5IL6, IL6R, CRP
30rituximab45 51 1111.5CRP, IL6R, IL6
31prednisolone45 29 1111.5CRP, IL6R, IL6
32methotrexate51 45 1111.5IL6, IL6R, CRP
33fibrinogen459.5CRP, IL6R, IL6
34creatinine459.4CRP, IL6R, IL6
35rantes459.4IL6R, IL9, IL6
36histamine45 29 2411.4IL6, IL9, IL6R
37thymidine45 2410.3IL6, IL9, IL6R
38testosterone45 61 24 1112.3CRP, IL6R, IL6
39atorvastatin45 51 29 24 1113.2CRP, IL6
40cholesterol45 29 24 1112.2IL6, IL6R, CRP
41okt3459.2CR2, CRP, IL6
42cyclosporin a45 29 6111.1IL6, IL6R, CR2
43vegf459.0IL6, IL6R, CRP
44lipid458.8IL6, IL9, IL6R, CRP
45cycloheximide458.7IL6, IL6R, CRP, CR2
46tyrosine458.4IL6, IL9, IL6R, CR2

GO Terms for genes affiliated with Castleman's Disease

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16Gene Ontology
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Cellular components related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:0058969.3IL6R, IL6
2extracellular spaceGO:0056158.5CRP, IL6R, IL9, IL6

Biological processes related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.0IL6R, IL6
2negative regulation of collagen biosynthetic processGO:0329669.9IL6, IL6R
3neutrophil mediated immunityGO:0024469.9IL6, IL6R
4interleukin-6-mediated signaling pathwayGO:0701029.9IL6R, IL6
5positive regulation of leukocyte chemotaxisGO:0026909.9IL6R, IL6
6positive regulation of chemokine productionGO:0327229.9IL6, IL6R
7monocyte chemotaxisGO:0025489.9IL6, IL6R
8defense response to Gram-negative bacteriumGO:0508299.9IL6R, IL6
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9IL6R, IL6
10negative regulation of lipid storageGO:0108889.9IL6, CRP
11positive regulation of interleukin-6 productionGO:0327559.8IL6, IL6R
12endocrine pancreas developmentGO:0310189.8IL6, IL6R
13positive regulation of smooth muscle cell proliferationGO:0486619.8IL6, IL6R
14positive regulation of osteoblast differentiationGO:0456699.7IL6, IL6R
15positive regulation of MAPK cascadeGO:0434109.6IL6, IL6R
16positive regulation of NF-kappaB transcription factor activityGO:0510929.6IL6R, IL6
17positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IL6, IL6R
18defense response to Gram-positive bacteriumGO:0508309.4CRP, IL6, IL6R
19acute-phase responseGO:0069539.4CRP, IL6, IL6R
20agingGO:0075689.2CRP, IL6
21complement activation, classical pathwayGO:0069589.2CR2, CRP
22inflammatory responseGO:0069549.2CRP, IL9, IL6
23positive regulation of cell proliferationGO:0082849.1IL9, IL6, IL6R

Molecular functions related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:0051389.3IL6R, IL6
2protein homodimerization activityGO:0428038.7CR2, CRP, IL6R

Products for genes affiliated with Castleman's Disease

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Sources for Castleman's Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet