MCID: CST002
MIFTS: 51

Castleman's Disease malady

Rare diseases, Immune diseases, Cancer diseases, Infectious diseases categories
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Summaries for Castleman's Disease

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NIH Rare Diseases:42 Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. while the cause of castleman's disease is unknown, many doctors suspect a virus is involved. problems with the way an individual's immune system functions may also contribute to the development of the condition. there are 2 main forms of castleman's disease: localized (discussed here) and multicentric. they affect people very differently. localized or unicentric castleman's disease only affects a single set of lymph nodes and is not widespread. the lymph nodes that are more commonly affected are in the chest and abdomen. castleman’s disease causes the lymph nodes to get larger. the enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. people with localized castleman's disease are often cured when the lymph node is removed with surgery. chemotherapy and radiation may also be used. last updated: 4/25/2012

MalaCards based summary: Castleman's Disease, also known as angiofollicular ganglionic hyperplasia, is related to kaposi's sarcoma and pancreatitis. An important gene associated with Castleman's Disease is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Transcription Androgen Receptor nuclear signaling and IL-17 Family Signaling Pathways. The compounds turpentine and iron sucrose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Castleman's Disease

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Sources:
42NIH Rare Diseases, 62UMLS, 44Novoseek
See all sources

Castleman's Disease, Aliases & Descriptions:

Name: Castleman's Disease 42
Angiofollicular Ganglionic Hyperplasia 42 62
Angiofollicular Lymph Hyperplasia 42 62
 
Angiolymphoid Hyperplasia 62
Castleman Disease 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases, Infectious diseases
Anatomical: Immune diseases


Related Diseases for Castleman's Disease

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Diseases in the Castleman's Disease family:

Localized Castleman Disease

Diseases related to Castleman's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1kaposi's sarcoma31.1IL6, IL6R
2pancreatitis30.4IL6, CRP
3systemic lupus erythematosus30.3CRP
4plasmacytoma30.3IL6, IL6R
5arthritis30.2IL6, IL6R, CRP
6multiple myeloma30.2IL6R, IL6
7rheumatoid arthritis30.1IL6R, IL6, CRP
8non-hodgkin lymphoma29.9IL6R, IL9, CR2
9hodgkin's lymphoma29.7IL6R, IL9
10leukemia29.0CR2, EVPL, IL9, IL6, IL6R
11sarcoma10.6
12angiofollicular lymph hyperplasia10.6
13aortic aneurysm10.4CRP
14bacteriuria10.4CRP
15bronchitis10.4CRP
16poems syndrome10.4
17multicentric castleman’s disease10.4
18crohn's disease10.4CRP
19pemphigus10.4
20localized castleman disease10.4
21paraneoplastic pemphigus10.4
22primary effusion lymphoma10.3
23adult-onset still's disease10.3IL6, CRP
24viral meningitis10.3CRP, IL6
25chorioamnionitis10.2CRP, IL6
26chronic obstructive pulmonary disease10.2CRP, IL6
27spiradenoma10.2IL6, CRP
28juvenile rheumatoid arthritis10.2CRP, IL6
29respiratory failure10.2IL6, CRP
30thrombocytosis10.2IL6, CRP
31meningitis10.2CRP, IL6
32leukopenia10.2CRP, IL6
33peritonitis10.2IL6, CRP
34synovitis10.2CRP, IL6
35acute pancreatitis10.2IL6, CRP
36periodontal disease10.2CRP, IL6
37rheumatic disease10.2IL6R, CRP
38nephrotic syndrome10.2
39colitis10.2IL6, IL6R
40galactosemia10.2IL6, CRP
41congenital heart disease10.1CRP, IL6
42deficiency anemia10.1
43hemolytic anemia10.1
44follicular dendritic cell sarcoma10.1
45autoimmune hemolytic anemia10.1
46iron deficiency anemia10.1
47dendritic cell sarcoma10.1
48microcytic anemia10.1
49angioimmunoblastic t-cell lymphoma10.1
50autoimmune pancreatitis10.1

Graphical network of the top 20 diseases related to Castleman's Disease:



Diseases related to castleman's disease

Symptoms for Castleman's Disease

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Drugs & Therapeutics for Castleman's Disease

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Drug clinical trials:

Search ClinicalTrials for Castleman's Disease

Search NIH Clinical Center for Castleman's Disease

Genetic Tests for Castleman's Disease

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Anatomical Context for Castleman's Disease

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MalaCards organs/tissues related to Castleman's Disease:

32
Lymph node, B cells, Lung, Kidney, T cells, Liver, Endothelial, Skin, Pancreas, Breast, Spleen, Heart, Colon, Ovary, Monocytes, Tongue

Animal Models for Castleman's Disease or affiliated genes

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MGI Mouse Phenotypes related to Castleman's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CR2, IL6R, IL9, IL6
2MP:00053877.5CR2, CRP, IL6R, IL9, IL6
3MP:00053767.3IL6, IL9, IL6R, CRP, CR2

Publications for Castleman's Disease

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Articles related to Castleman's Disease:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Successful use of tocilizumab in a case of multicentric Castleman's disease and end-stage renal disease. (24571441)
2014
2
Retroperitoneal unicentric Castleman's disease-a hyaline vascular challenge. (25118641)
2014
3
Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient. (25169666)
2014
4
Castleman's disease mimicked gynaecological adnexal tumour. (24831584)
2014
5
Reversal of cardiomyopathy with tocilizumab in a case of HIV-negative Castleman's disease. (23786462)
2013
6
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
7
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
8
The spectrum of Castleman's disease: mimics, radiologic pathologic correlation and role of imaging in patient management. (20643523)
2012
9
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease. (23102767)
2012
10
Castleman's Disease: A Case Report of the Unicentric Type. (22991681)
2012
11
The characterization and management of Castleman's disease. (22971511)
2012
12
Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report. (21577263)
2011
13
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
14
Solitary intra-abdominal Castleman's disease, hyaline vascular type: case report. (20164010)
2010
15
Highly active antiretroviral therapy alone may be an effective treatment for HIV-associated multi-centric Castleman's disease. (20801900)
2010
16
Castleman's disease of the parotid gland: a case report. (20705256)
2010
17
Castleman's disease in the head and neck region: Meta-analysis of reported cases in Taiwan and literature review. (21195890)
2010
18
Castleman's disease: a study of a rare lymphoproliferative disorder in a university hospital. (20164006)
2010
19
Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report. (20205844)
2010
20
Vinblastine, rituximab and HAART, treatment of an HIV -positive patient with multicentric Castleman's disease. (20167961)
2010
21
The analysis of interleukin-6 in patients with systemic IgG4-related plasmacytic syndrome--expansion of SIPS to the territory of Castleman's disease. (19447768)
2009
22
Splenectomy-induced long-term remission in a patient with multicentric Castleman's disease. (19767666)
2009
23
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
24
Castleman's disease: an intrapulmonary form with intrafissural development. (19768350)
2009
25
A rare case of Castleman's disease of plasma cell type within kidney. (20079147)
2009
26
Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection. (19298351)
2009
27
A case of POEMS syndrome with mixed hyaline vascular and plasma cell type Castleman's disease. (19670555)
2009
28
Hyaline vascular-type Castleman's disease of the retroperitoneum. (18677335)
2008
29
Multicentric Castleman's disease presenting with multiple nodes in lungs: a case report and literature review. (18815726)
2008
30
Unicentric Castleman's disease in peripancreatic tissue: case report and review of the literature. (18419976)
2008
31
FDG-PET and diffusion-weighted MR imaging appearance in retroperitoneal Castleman's disease: a case report. (18313580)
2008
32
Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease. (17541233)
2007
33
Castleman's disease of the axilla mimicking metastasis. (17996608)
2007
34
Castleman's disease and retroviral therapy. (17931977)
2007
35
Are multicentric Castleman's disease with cutaneous plasmacytosis and systemic plasmacytosis the same entity? (17064311)
2006
36
Interfollicular Hodgkin's lymphoma and Castleman's disease. (16430484)
2006
37
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
38
Castleman's disease as an unusual neck mass: case report. (15224829)
2004
39
Castleman's disease of the lacrimal gland. (14746606)
2004
40
Remission of nephrotic syndrome after thalidomide therapy in a patient with Castleman's disease. (15182131)
2004
41
Castleman's disease. (14585575)
2003
42
Hyaline vascular Castleman's disease: a case report and brief review of the literature. (12685494)
2002
43
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10702388)
2000
44
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
45
Castleman's disease. (10655569)
1999
46
A case of multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia. (9627044)
1998
47
Castleman's disease in a 44-year-old male with neurofibromatosis and pheochromocytoma. (9477139)
1997
48
A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects. (8695726)
1996
49
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. (1953537)
1991
50
Angiofollicular lymph node hyperplasia (Castleman's disease) in an adolescent female. Clinical and immunologic findings. (1873789)
1991

Variations for Castleman's Disease

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Expression for genes affiliated with Castleman's Disease

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Expression patterns in normal tissues for genes affiliated with Castleman's Disease

Search GEO for disease gene expression data for Castleman's Disease.

Pathways for genes affiliated with Castleman's Disease

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Pathways related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.6IL6R, IL6
2
Show member pathways
9.6IL6R, IL6
39.6IL6R, IL6
49.6IL6, IL6R
5
Show member pathways
9.6IL6R, IL6
69.6IL6R, IL6
7
Show member pathways
9.6IL6R, IL6
8
Show member pathways
9.6IL6R, IL6
99.6IL6R, IL6
10
Show member pathways
thioredoxin pathway37
9.5CRP, IL6
119.4IL9, IL6
129.4IL9, IL6
13
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.1CRP, CR2
149.1CRP, IL6R, IL6
15
Show member pathways
Type III interferon signaling37
9.0IL6, IL9, IL6R
16
Show member pathways
9.0IL6, IL9, IL6R
17
Show member pathways
9.0IL6, IL9, IL6R
18
Show member pathways
9.0IL6, IL9, IL6R
19
Show member pathways
9.0IL6R, IL9, IL6
20
Show member pathways
8.9IL6, IL9, CRP
218.8CR2, IL6R, IL6
22
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.6IL6, IL9, CR2

Compounds for genes affiliated with Castleman's Disease

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Compounds related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1turpentine4410.0CRP, IL6
2iron sucrose4410.0IL6, CRP
3cdp5714410.0CRP, IL6
4bucillamine4410.0CRP, IL6
5tenidap44 2811.0IL6, CRP
6anakinra44 1111.0CRP, IL6
7gabexate mesilate4410.0CRP, IL6
8pamidronate44 50 1111.9CRP, IL6
9il 10449.9IL6R, IL6
10adalimumab44 50 1111.9IL6, CRP
11pmma449.9IL6, CRP
12rosuvastatin44 50 28 1112.9CRP, IL6
138-isoprostane449.9CRP, IL6
14etanercept44 50 1111.9CRP, IL6
15deoxypyridinoline449.9CRP, IL6R
16ifn-alpha449.9IL6, IL6R
17infliximab44 50 1111.8IL6, CRP
18fenofibrate44 50 1111.8CRP, IL6
19ivig449.8CRP, IL6
20fluvastatin44 50 28 1112.8CRP, IL6
21methylcellulose449.8IL9, IL6
22pioglitazone28 44 50 1112.7CRP, IL6
23thalidomide44 50 61 1112.7IL6R, IL6
24methacholine44 50 1111.6CRP, IL9
25gp 130449.6IL6R, IL6
26pravastatin44 50 28 24 1113.6CRP, IL6
27rosiglitazone28 44 50 24 1113.5CRP, IL6
28tocilizumab44 1110.5CRP, IL6R, IL6
29neopterin449.5IL6, IL6R, CRP
30rituximab44 50 1111.5CRP, IL6R, IL6
31prednisolone44 28 1111.5CRP, IL6R, IL6
32methotrexate50 44 1111.5IL6, IL6R, CRP
33fibrinogen449.5CRP, IL6R, IL6
34creatinine449.4CRP, IL6R, IL6
35rantes449.4IL6R, IL9, IL6
36histamine44 28 2411.4IL6, IL9, IL6R
37thymidine44 2410.3IL6, IL9, IL6R
38testosterone44 61 24 1112.3CRP, IL6R, IL6
39atorvastatin44 50 28 24 1113.2CRP, IL6
40cholesterol44 28 24 1112.2IL6, IL6R, CRP
41okt3449.2CR2, CRP, IL6
42cyclosporin a44 28 6111.1IL6, IL6R, CR2
43vegf449.0IL6, IL6R, CRP
44lipid448.8IL6, IL9, IL6R, CRP
45cycloheximide448.7IL6, IL6R, CRP, CR2
46tyrosine448.4IL6, IL9, IL6R, CR2

GO Terms for genes affiliated with Castleman's Disease

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Cellular components related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:0058969.3IL6R, IL6
2extracellular spaceGO:0056158.5CRP, IL6R, IL9, IL6

Biological processes related to Castleman's Disease according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.0IL6, IL6R
2negative regulation of collagen biosynthetic processGO:0329669.9IL6R, IL6
3neutrophil mediated immunityGO:0024469.9IL6R, IL6
4interleukin-6-mediated signaling pathwayGO:0701029.9IL6R, IL6
5positive regulation of leukocyte chemotaxisGO:0026909.9IL6R, IL6
6positive regulation of chemokine productionGO:0327229.9IL6, IL6R
7monocyte chemotaxisGO:0025489.9IL6R, IL6
8defense response to Gram-negative bacteriumGO:0508299.9IL6R, IL6
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9IL6, IL6R
10negative regulation of lipid storageGO:0108889.9IL6, CRP
11positive regulation of interleukin-6 productionGO:0327559.8IL6, IL6R
12endocrine pancreas developmentGO:0310189.8IL6, IL6R
13positive regulation of smooth muscle cell proliferationGO:0486619.8IL6R, IL6
14positive regulation of osteoblast differentiationGO:0456699.7IL6R, IL6
15positive regulation of MAPK cascadeGO:0434109.6IL6, IL6R
16positive regulation of NF-kappaB transcription factor activityGO:0510929.6IL6R, IL6
17positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IL6R, IL6
18defense response to Gram-positive bacteriumGO:0508309.4CRP, IL6R, IL6
19acute-phase responseGO:0069539.4CRP, IL6R, IL6
20agingGO:0075689.2CRP, IL6
21complement activation, classical pathwayGO:0069589.2CR2, CRP
22inflammatory responseGO:0069549.2CRP, IL9, IL6
23positive regulation of cell proliferationGO:0082849.1IL6, IL9, IL6R

Molecular functions related to Castleman's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:0051389.3IL6R, IL6
2protein homodimerization activityGO:0428038.7CR2, CRP, IL6R

Products for genes affiliated with Castleman's Disease

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Sources for Castleman's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet