MCID: CTS002
MIFTS: 51

Cat-Scratch Disease

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Cat-Scratch Disease

MalaCards integrated aliases for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 55 41 14 69
Cat Scratch Disease 72 49 40 3
Bartonellosis Due to Bartonella Henselae Infection 49 55
Cat Scratch Fever 12 49
Debre's Syndrome 12 69
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 69

Characteristics:

Orphanet epidemiological data:

55
cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11258
ICD10 32 A28.1
ICD9CM 34 078.3
MeSH 41 D002372
NCIt 46 C84620
Orphanet 55 ORPHA50839
MESH via Orphanet 42 D002372
UMLS via Orphanet 70 C0007361 C0238909
ICD10 via Orphanet 33 A28.1

Summaries for Cat-Scratch Disease

MedlinePlus : 40 Cat scratch disease (CSD) is an illness caused by the bacterium Bartonella henselae. Almost half of all cats carry the infection at some point. The infection does not make cats sick. However, the scratch or bite of an infected cat can cause symptoms in people, including Swollen lymph nodes, especially around the head, neck, and upper limbs Fever Headache Fatigue Poor appetite For people with weak immune systems, CSD may cause more serious problems. The best way to avoid CSD is to avoid rough play with cats that could lead to scratches or bites. If you do get a scratch or bite, wash it well with soap and water. If the bite or scratch gets infected or if you have symptoms of CSD, call your doctor. Centers for Disease Control and Prevention

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to carrion's disease and bartonellosis, and has symptoms including regional lymphadenopathy, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Tuberculosis. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lymph node and skin.

NIH Rare Diseases : 49 Cat scratch disease is an infectious illness caused by the bacteria bartonella (Bartonella henselae). It is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. This self-limiting infectious disease is characterized by a bump or blister at the site of the bite or scratch and swelling and pain in the lymph nodes. Other features may include fatigue, headache, achiness, and fever. Although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may help speed recovery. Last updated: 7/20/2016

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Disease Ontology : 12 A bartonellosis that results_in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

Wikipedia : 72 Cat-scratch disease (CSD) is a common and usually benign infectious disease caused by the bacterium... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 carrion's disease 32.0 CD40LG HSPD1
2 bartonellosis 31.0 CD40LG CS EEA1 HSPD1 HTRA1
3 ehrlichiosis 30.1 CD40LG HSPD1
4 q fever 30.0 CD40LG IFNG
5 brucellosis 30.0 CD40LG IFNG
6 lyme disease 29.9 CD40LG HSPD1
7 meningitis 29.9 CD40LG IFNG
8 bone inflammation disease 29.9 CD40LG IFNG
9 toxoplasmosis 29.9 CD40LG IFNG
10 reactive arthritis 29.9 HSPD1 IFNG
11 acquired immunodeficiency syndrome 29.8 CD40LG IFNG
12 chlamydia 29.5 CD40LG HSPD1 IFNG
13 neuroretinitis 11.5
14 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.5
15 trench fever 11.4
16 pars planitis 11.1
17 osteomyelitis 10.5
18 encephalopathy 10.4
19 angiomatosis 10.4
20 hepatitis 10.4
21 lymphadenitis 10.4
22 retinitis 10.4
23 post-vaccinal encephalitis 10.4 CD40LG HTRA1
24 episodic pain syndrome, familial, 1 10.3
25 bacillary angiomatosis 10.3
26 status epilepticus 10.3
27 spotted fever 10.2 HTRA1 IFNG
28 african tick-bite fever 10.2 CD40LG IFNG
29 sporotrichosis 10.2 CD40LG IFNG
30 fallopian tube disease 10.2 CD40LG HSPD1
31 salpingitis 10.2 CD40LG HSPD1
32 urethritis 10.2 CD40LG HSPD1
33 buruli ulcer 10.2 CD40LG IFNG
34 central nervous system vasculitis 10.2 CD40LG IFNG
35 human granulocytic anaplasmosis 10.2 CD40LG HSPD1
36 cutaneous lupus erythematosus 10.2 CD40LG EEA1
37 primary systemic mycosis 10.2 CD40LG IFNG
38 coccidiosis 10.2 CD40LG IFNG
39 hemorrhagic fever 10.2 CD40LG IFNG
40 endocardium disease 10.2 CD40LG HSPD1
41 lichen disease 10.2 CD40LG IFNG
42 cervicitis 10.2
43 plasmodium vivax malaria 10.2 CD40LG IFNG
44 hepatitis e 10.2 CD40LG IFNG
45 pelvic inflammatory disease 10.2 CD40LG HSPD1
46 hypersensitivity reaction type iv disease 10.2 CD40LG IFNG
47 autoimmune disease of gastrointestinal tract 10.2 CD40LG IFNG
48 opportunistic mycosis 10.2 CD40LG IFNG
49 vernal conjunctivitis 10.2 CD40LG IFNG
50 echinococcosis 10.2 CD40LG IFNG

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease

Symptoms:

12
  • regional lymphadenopathy
  • headache
  • chills
  • backache
  • abdominal pain

UMLS symptoms related to Cat-Scratch Disease:


pruritus, fever

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Gentamicins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cat-Scratch Disease:

18
Lymph Node

MalaCards organs/tissues related to Cat-Scratch Disease:

38
Lymph Node, Skin, Eye, Bone, Testes, Breast, Liver

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 568)
# Title Authors Year
1
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
2
Utility of Bartonella henselae IgM Western Blot Bands for Serodiagnosis of Cat Scratch Disease. ( 29093103 )
2018
3
Disseminated cat-scratch disease presenting as nausea, diarrhea, and weight loss without fever in a heart transplant recipient. ( 28199763 )
2017
4
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. ( 27997427 )
2017
5
A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease. ( 28935172 )
2017
6
Detection of Bartonella in cat scratch disease using a single-step PCR assay kit. ( 29068281 )
2017
7
Diverse Clinical Signs of Ocular Involvement in Cat Scratch Disease. ( 28182175 )
2017
8
Cat Scratch Disease During Adalimumab Therapy: A Case Report. ( 29132747 )
2017
9
Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease. ( 28669017 )
2017
10
Cat scratch disease during etanercept therapy in a rheumatoid arthritis patient. ( 28256443 )
2017
11
Cat scratch disease: U.S. clinicians' experience and knowledge. ( 28707827 )
2017
12
CAT SCRATCH DISEASE IMITATING A TOXOCARA GRANULOMA OF THE OPTIC DISK. ( 29176527 )
2017
13
Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. ( 29239936 )
2017
14
Cat scratch disease. Onset as epithroclear tumor. ( 28416228 )
2017
15
Cat Scratch Disease: Not a Benign Condition. ( 28665750 )
2017
16
Torticollis and Fever in a Young Boy: A Unique Presentation of Cat-Scratch Disease With Vertebral Osteomyelitis and Epidural Phlegmon. ( 29095386 )
2017
17
Cat Scratch Disease in a Renal Transplant Recipient. ( 27312684 )
2016
18
Cat Scratch Disease: Expanded Spectrum. ( 27843905 )
2016
19
The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. ( 28029424 )
2016
20
Corticosteroid Treatment for Prolonged Fever in Hepatosplenic Cat-Scratch Disease. ( 28006985 )
2016
21
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report. ( 27662446 )
2016
22
Disseminated cat-scratch disease: case report and review of the literature. ( 27077606 )
2016
23
Atypical Cat Scratch Disease With Hepatosplenic Involvement. ( 27484614 )
2016
24
Cat-Scratch Disease in the United States, 2005-2013. ( 27648778 )
2016
25
Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N-Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease. ( 26865692 )
2016
26
Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. ( 27193359 )
2016
27
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2016
28
Cat-scratch disease with hepatosplenic lesions in two brothers. ( 27051576 )
2016
29
Disseminated cat-scratch disease in an adult with selective IgA deficiency. ( 27257449 )
2016
30
Cat scratch disease in 9-year-old patient - a case report. ( 27213258 )
2016
31
Cat scratch disease of the parotid gland. ( 26403943 )
2015
32
New-onset refractory status epilepticus in an adult with an atypical presentation of cat-scratch disease: successful treatment with high-dose corticosteroids. ( 26044784 )
2015
33
Disseminated cat-scratch disease: case report and review of the literature. ( 25940800 )
2015
34
Choroidal neovascularisation as an unusual ophthalmic manifestation of cat-scratch disease in an 8-year-old girl. ( 26135983 )
2015
35
Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease. ( 26576306 )
2015
36
Renal Microabscesses: A Presentation of Cat Scratch Disease. ( 25799194 )
2015
37
Cat-scratch disease: a wide spectrum of clinical pictures. ( 26161064 )
2015
38
Hepatosplenic Cat-Scratch Disease in Children and the Positive Contribution of 18F-FDG Imaging. ( 26164171 )
2015
39
Cat scratch disease in an immunosuppressed patient with systemic lupus erythematosus. ( 26453661 )
2015
40
Progressive Cat Scratch Disease Despite Antimicrobial Therapy. ( 26407443 )
2015
41
Cat-scratch disease presenting as a solitary splenic abscess in an elderly man. ( 25804947 )
2015
42
Multiple Renal and Splenic Lesions in a Child with Cat Scratch Disease. ( 26567841 )
2015
43
Posterior segment involvement in cat-scratch disease: A case series. ( 26545331 )
2015
44
Atypical manifestation of cat-scratch disease: isolated epigastric pain in an immunocompetent, 12-year-old child. ( 26273467 )
2015
45
Cat scratch disease during infliximab therapy: a case report and literature review. ( 25547623 )
2015
46
Persistent cat scratch disease requiring surgical excision in a patient with MPGN. ( 25963015 )
2015
47
Evaluation of Cat Scratch Disease Cases Reported from Turkey between 1996 and 2013 and Review of the Literature. ( 26851430 )
2015
48
Cat-Scratch Disease: Case Report and Review of the Literature. ( 26361690 )
2015
49
Sonography of cat scratch disease. ( 25715359 )
2015
50
Cat-scratch disease with severe pleuritis in a 6-year-old girl. ( 26113319 )
2015

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

Pathways related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CD40LG IFNG
2 11.18 CORO1A EEA1 HSPD1 IFNG
3
Show member pathways
11.12 CD40LG IFNG
4 11.05 CS HSPD1
5 10.85 CD40LG IFNG
6 10.47 CD40LG IFNG

GO Terms for Cat-Scratch Disease

Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 8.8 CORO1A EEA1 HSPD1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 movement of cell or subcellular component GO:0006928 9.37 CORO1A IFNG
2 positive regulation of T cell proliferation GO:0042102 9.32 CD40LG CORO1A
3 B cell proliferation GO:0042100 9.26 CD40LG HSPD1
4 positive regulation of T cell activation GO:0050870 9.16 CORO1A HSPD1
5 positive regulation of interleukin-10 production GO:0032733 8.96 CD40LG HSPD1
6 positive regulation of interleukin-12 production GO:0032735 8.8 CD40LG HSPD1 IFNG

Sources for Cat-Scratch Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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