MCID: CTS002
MIFTS: 46

Cat-Scratch Disease malady

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Cat-Scratch Disease

Aliases & Descriptions for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 56 42 14 69
Cat Scratch Disease 50 41 3
Bartonellosis Due to Bartonella Henselae Infection 50 56
Cat Scratch Fever 12 50
Debre's Syndrome 12 69
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 69

Characteristics:

Orphanet epidemiological data:

56
cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11258
ICD10 33 A28.1
ICD9CM 35 078.3
MeSH 42 D002372
NCIt 47 C84620
Orphanet 56 ORPHA50839
MESH via Orphanet 43 D002372
UMLS via Orphanet 70 C0007361
ICD10 via Orphanet 34 A28.1
UMLS 69 C0007361

Summaries for Cat-Scratch Disease

MedlinePlus : 41 cat scratch disease (csd) is an illness caused by the bacterium bartonella henselae. almost half of all cats carry the infection at some point. the infection does not make cats sick. however, the scratch or bite of an infected cat can cause symptoms in people, including swollen lymph nodes, especially around the head, neck, and upper limbs fever headache fatigue poor appetite for people with weak immune systems, csd may cause more serious problems. the best way to avoid csd is to avoid rough play with cats that could lead to scratches or bites. if you do get a scratch or bite, wash it well with soap and water. if the bite or scratch gets infected or if you have symptoms of csd, call your doctor. centers for disease control and prevention

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to chlamydia and neuroretinitis, and has symptoms including regional lymphadenopathy, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Tuberculosis and Mitochondrial protein import. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and eye.

NIH Rare Diseases : 50 cat scratch disease is an infectious illness caused by the bacteria bartonella (bartonella henselae). it is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. this self-limiting infectious disease is characterized by a bump or blister at the site of the bite or scratch and swelling and pain in the lymph nodes. other features may include fatigue, headache, achiness, and fever. although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may help speed recovery. last updated: 7/20/2016

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Disease Ontology : 12 A bartonellosis that results_in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

Wikipedia : 71 Cat-scratch disease (CSD) is a common and usually benign infectious disease caused by the bacterium... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 chlamydia 28.1 CD40LG CERKL CORO1A CS EEA1 HSPD1
2 neuroretinitis 11.4
3 bartonellosis 11.4
4 trench fever 11.3
5 intermediate uveitis 11.3
6 diarrhea 3, secretory sodium, congenital, syndromic 11.0
7 pars planitis 11.0
8 carrion's disease 11.0
9 osteomyelitis 10.4
10 encephalopathy 10.4
11 angiomatosis 10.3
12 retinitis 10.3
13 hepatitis 10.3
14 lymphadenitis 10.3
15 bacillary angiomatosis 10.2
16 status epilepticus 10.2
17 chronic duodenal ileus 10.2 CD40LG HTRA1
18 cervicitis 10.1
19 leiomyosarcoma 10.1 CD40LG HSPD1
20 ovarian serous cystadenocarcinoma 10.1 CD40LG HSPD1
21 basilar artery occlusion 10.1 CD40LG HSPD1
22 powassan encephalitis 10.1 CD40LG EEA1
23 african tick-bite fever 10.1 CD40LG HSPD1
24 arrhythmogenic right ventricular cardiomyopathy 10.1 CD40LG HSPD1
25 pancreatic signet ring cell adenocarcinoma 10.1 CD40LG HSPD1
26 hyperlucent lung 10.1 CD40LG HSPD1
27 vasculitis 10.0
28 splenic abscess 10.0
29 myelitis 10.0
30 uterine adnexa cancer 10.0 CD40LG HSPD1
31 dracunculiasis 10.0 CD40LG CS
32 keratomalacia 10.0 CD40LG HSPD1
33 intracranial hemorrhage in brain cerebrovascular malformations 10.0 CD40LG HSPD1
34 ciliary body spindle cell melanoma 10.0 CD40LG CORO1A
35 epidural abscess 10.0
36 choroiditis 10.0
37 endocarditis 10.0
38 neuropathy 10.0
39 granulomatous hepatitis 10.0
40 encephalitis 10.0
41 retinal detachment 10.0
42 uveitis 10.0
43 transverse myelitis 10.0
44 lymphoma 10.0
45 mesothelioma, somatic 10.0 CD40LG HSPD1
46 lymphogranuloma venereum 9.9
47 breast cancer 9.9
48 bacteremia 9.9
49 duodenitis 9.9
50 keratitis 9.9

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease

Symptoms:

12
  • regional lymphadenopathy
  • headache
  • chills
  • backache
  • abdominal pain

UMLS symptoms related to Cat-Scratch Disease:


fever, pruritus

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Gentamicins Phase 3
12 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Not yet recruiting NCT03132116 Phase 3
3 Risk Factors of Cat Scratch Colon Developing. Completed NCT01574547

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

MalaCards organs/tissues related to Cat-Scratch Disease:

39
Lymph Node, Skin, Eye, Bone, Testes, Breast, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Cat-Scratch Disease:

18
Lymph Node

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 553)
id Title Authors Year
1
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. ( 27997427 )
2017
2
Cat Scratch Disease: Expanded Spectrum. ( 27843905 )
2016
3
Disseminated cat-scratch disease in an adult with selective IgA deficiency. ( 27257449 )
2016
4
Corticosteroid Treatment for Prolonged Fever in Hepatosplenic Cat-Scratch Disease. ( 28006985 )
2016
5
Cat-scratch disease with hepatosplenic lesions in two brothers. ( 27051576 )
2016
6
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report. ( 27662446 )
2016
7
Atypical Cat Scratch Disease With Hepatosplenic Involvement. ( 27484614 )
2016
8
Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. ( 27193359 )
2016
9
Cat Scratch Disease in a Renal Transplant Recipient. ( 27312684 )
2016
10
Cat scratch disease in 9-year-old patient - a case report. ( 27213258 )
2016
11
Cat-Scratch Disease in the United States, 2005-2013. ( 27648778 )
2016
12
Disseminated cat-scratch disease: case report and review of the literature. ( 27077606 )
2016
13
Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N-Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease. ( 26865692 )
2016
14
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2016
15
The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. ( 28029424 )
2016
16
Progressive Cat Scratch Disease Despite Antimicrobial Therapy. ( 26407443 )
2015
17
Cat-scratch disease with severe pleuritis in a 6-year-old girl. ( 26113319 )
2015
18
Disseminated cat-scratch disease: case report and review of the literature. ( 25940800 )
2015
19
Cat-scratch disease presenting as a solitary splenic abscess in an elderly man. ( 25804947 )
2015
20
Cat scratch disease in an immunosuppressed patient with systemic lupus erythematosus. ( 26453661 )
2015
21
Cat-Scratch Disease: Case Report and Review of the Literature. ( 26361690 )
2015
22
Choroidal neovascularisation as an unusual ophthalmic manifestation of cat-scratch disease in an 8-year-old girl. ( 26135983 )
2015
23
Sonography of cat scratch disease. ( 25715359 )
2015
24
Cat scratch disease during infliximab therapy: a case report and literature review. ( 25547623 )
2015
25
Persistent cat scratch disease requiring surgical excision in a patient with MPGN. ( 25963015 )
2015
26
Multiple Renal and Splenic Lesions in a Child with Cat Scratch Disease. ( 26567841 )
2015
27
Hepatosplenic Cat-Scratch Disease in Children and the Positive Contribution of 18F-FDG Imaging. ( 26164171 )
2015
28
New-onset refractory status epilepticus in an adult with an atypical presentation of cat-scratch disease: successful treatment with high-dose corticosteroids. ( 26044784 )
2015
29
Cat scratch disease of the parotid gland. ( 26403943 )
2015
30
Evaluation of Cat Scratch Disease Cases Reported from Turkey between 1996 and 2013 and Review of the Literature. ( 26851430 )
2015
31
Status Epilepticus Due to Cat Scratch Disease: Recognition, Diagnosis, and Thoughts on Pathogenesis. ( 25853722 )
2015
32
Cat-scratch disease: a wide spectrum of clinical pictures. ( 26161064 )
2015
33
Renal Microabscesses: A Presentation of Cat Scratch Disease. ( 25799194 )
2015
34
Posterior segment involvement in cat-scratch disease: A case series. ( 26545331 )
2015
35
Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease. ( 26576306 )
2015
36
Atypical manifestation of cat-scratch disease: isolated epigastric pain in an immunocompetent, 12-year-old child. ( 26273467 )
2015
37
Hepatosplenic cat scratch disease in immunocompetent adults: report of 3 cases and review of the literature. ( 25803522 )
2014
38
Cat scratch disease associated with retinal vein occlusion. ( 25269350 )
2014
39
Hepatosplenic cat scratch disease in immunocompetent adults: report of 3 cases and review of the literature. ( 25398062 )
2014
40
Cat scratch disease, a rare cause of hypodense liver lesions, lymphadenopathy and a protruding duodenal lesion, caused by Bartonella henselae. ( 25355744 )
2014
41
Cat scratch disease in MedellA-n, Colombia. ( 25988023 )
2014
42
Cat scratch disease. ( 25199244 )
2014
43
Cat scratch disease of the eye: a case report and literature review. ( 25643469 )
2014
44
Cat Scratch Disease in kidney transplant receptors: is it a rare or underdiagnosed pathology? ( 25317626 )
2014
45
Acute myopericarditis associated with cat scratch disease in an adolescent. ( 24732446 )
2014
46
An uncommon cause of linfadenopathy in a kidney transplant patient: cat-scratch disease. ( 25036076 )
2014
47
A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view. ( 24641870 )
2014
48
Visceral cat scratch disease with endocarditis in an immunocompetent adult: a case report and review of the literature. ( 24575798 )
2014
49
Molecular identification of Bartonella henselae in a seronegative cat scratch disease patient with AIDS in Rio de Janeiro, Brazil. ( 25076441 )
2014
50
Atypical presentation of cat-scratch disease in an immunocompetent child with serological and pathological evidence. ( 25610689 )
2014

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

Pathways related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.05 CORO1A EEA1 HSPD1
2 10.75 CS HSPD1

GO Terms for Cat-Scratch Disease

Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CORO1A CS EEA1 HSPD1 HTRA1
2 early endosome GO:0005769 8.8 CORO1A EEA1 HSPD1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.32 CD40LG CORO1A
2 B cell proliferation GO:0042100 9.26 CD40LG HSPD1
3 positive regulation of T cell activation GO:0050870 9.16 CORO1A HSPD1
4 positive regulation of interleukin-12 production GO:0032735 8.96 CD40LG HSPD1
5 positive regulation of interleukin-10 production GO:0032733 8.62 CD40LG HSPD1

Sources for Cat-Scratch Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....