MCID: CTS002
MIFTS: 45

Cat-Scratch Disease malady

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Cat-Scratch Disease

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Sources:
2CDC, 11Disease Ontology, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 37MedlinePlus, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Cat-Scratch Disease:

Name: Cat-Scratch Disease 11 53 38 67
Cat Scratch Disease 47 37 2
Bartonellosis Due to Bartonella Henselae Infection 47 53
Cat Scratch Fever 11 47
Debre's Syndrome 11 67
 
Foshay-Mollaret Cat Scratch Fever 11
Benign Lymphoreticulosis 11
Debre-Mollaret Syndrome 11
Oroya Fever 67

Characteristics:

Orphanet epidemiological data:

53
cat-scratch disease:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:11258
ICD1029 A28.1
ICD9CM31 078.3
MeSH38 D002372
NCIt44 C84620
Orphanet53 ORPHA50839
MESH via Orphanet39 D002372
UMLS via Orphanet68 C0007361
ICD10 via Orphanet30 A28.1

Summaries for Cat-Scratch Disease

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MedlinePlus:37 Cat scratch disease (csd) is an illness caused by the bacterium bartonella henselae. almost half of all cats carry the infection at some point. the infection does not make cats sick. however, the scratch or bite of an infected cat can cause symptoms in people, including swollen lymph nodes, especially around the head, neck, and upper limbs fever headache fatigue poor appetite for people with weak immune systems, csd may cause more serious problems. the best way to avoid csd is to avoid rough play with cats that could lead to scratches or bites. if you do get a scratch or bite, wash it well with soap and water. if the bite or scratch gets infected or if you have symptoms of csd, call your doctor. centers for disease control and prevention

MalaCards based summary: Cat-Scratch Disease, also known as cat scratch disease, is related to neuroretinitis and bartonellosis, and has symptoms including regional lymphadenopathy, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways are Mitochondrial protein import and Tuberculosis. Affiliated tissues include lymph node, lymph node and skin.

Disease Ontology:11 A bartonellosis that results in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

CDC:2 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión's disease, caused by B. bacilliformis.

Wikipedia:70 Cat-scratch disease (CSD) is a common and usually benign infectious disease caused by the bacterium... more...

Related Diseases for Cat-Scratch Disease

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Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1neuroretinitis11.4
2bartonellosis11.4
3trench fever11.4
4intermediate uveitis11.4
5mucopolysaccharidosis is11.2
6diarrhea 3, secretory sodium, congenital, syndromic11.0
7carrion's disease11.0
8pars planitis11.0
9osteomyelitis10.4
10encephalopathy10.4
11angiomatosis10.3
12hepatitis10.3
13retinitis10.3
14sapho syndrome10.3CD40LG, HTRA1
15lymphadenitis10.3
16bacillary angiomatosis10.2
17status epilepticus10.2
18fallopian tube leiomyosarcoma10.1CD40LG, HSPD1
19small intestinal vasoactive intestinal peptide producing tumor10.1CD40LG, HSPD1
20cervicitis10.1
21strawberry gallbladder10.1CD40LG, CORO1A
22mineral metabolism disease10.1CD40LG, HSPD1
23restless legs syndrome10.1CD40LG, HSPD1
24postcricoid region cancer10.1CD40LG, CORO1A
25tuberculoid leprosy10.1CD40LG, HSPD1
26splenic abscess10.0
27myelitis10.0
28vasculitis10.0
29bile duct signet ring cell carcinoma10.0CD40LG, HSPD1
30lymphoma10.0
31endocarditis10.0
32epidural abscess10.0
33choroiditis10.0
34uveitis10.0
35granulomatous hepatitis10.0
36retinal detachment10.0
37neuropathy10.0
38encephalitis10.0
39transverse myelitis10.0
40parametrium malignant neoplasm10.0CD40LG, HSPD1
41labyrinthine bilateral reactive loss9.9CD40LG, CS
42opportunistic bacterial infectious disease9.9CD40LG, HSPD1
43goodpasture syndrome9.9CD40LG, HSPD1
44breast cancer9.9
45bacteremia9.9
46keratitis9.9
47retinal vasculitis9.9
48optic neuritis9.9
49aseptic meningitis9.9
50lymphogranuloma venereum9.9

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to cat-scratch disease

Symptoms for Cat-Scratch Disease

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Symptoms:

 11 (show all 5)
  • regional lymphadenopathy
  • headache
  • chills
  • backache
  • abdominal pain

UMLS symptoms related to Cat-Scratch Disease:


pruritus

Drugs & Therapeutics for Cat-Scratch Disease

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Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AzithromycinapprovedPhase 433383905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
2
Prednisoneapproved, vet_approvedPhase 4135953-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
3Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
4HormonesPhase 413979
5Hormone AntagonistsPhase 412778
6Antineoplastic Agents, HormonalPhase 45407
7glucocorticoidsPhase 44920
8Anti-Inflammatory AgentsPhase 410355
9ColaNutraceutical1881

Interventional clinical trials:

idNameStatusNCT IDPhase
1The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch DiseaseUnknown statusNCT01469702Phase 4
2Risk Factors of Cat Scratch Colon Developing.CompletedNCT01574547

Search NIH Clinical Center for Cat-Scratch Disease


Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

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Anatomical Context for Cat-Scratch Disease

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MalaCards organs/tissues related to Cat-Scratch Disease:

35
Lymph node, Skin, Eye, Bone, Testes, Breast, Colon

FMA organs/tissues related to Cat-Scratch Disease:

17
Lymph node

Animal Models for Cat-Scratch Disease or affiliated genes

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Publications for Cat-Scratch Disease

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Articles related to Cat-Scratch Disease:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. (27997427)
2017
2
Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. (27193359)
2016
3
Cat scratch disease in MedellA-n, Colombia. (25988023)
2014
4
Thoracic vertebral osteomyelitis with paraspinous mass and intraspinal extension: an atypical presentation of cat-scratch disease. (21594549)
2012
5
Optic neuropathy and cat scratch disease. (21779676)
2011
6
Seasonality of cat-scratch disease, France, 1999-2009. (21470466)
2011
7
Images in emergency medicine. Right axillary mass. Cat scratch disease. (21111249)
2010
8
Cat scratch disease: clinical considerations for the pediatric dentist. (19320261)
2009
9
Localised retinal vasculitis in cat scratch disease. (21686569)
2009
10
Cat scratch disease. (19247139)
2009
11
Neuroretinitis secondary to concurrent infection with cat scratch disease and lyme disease. (18791545)
2009
12
Severe occlusive vasculitis as a complication of cat scratch disease. (18454406)
2008
13
Feline bartonellosis and cat scratch disease. (18295347)
2008
14
Cat scratch disease. (17582885)
2007
15
Evaluation of an internally controlled real-time polymerase chain reaction assay targeting the groEL gene for the detection of Bartonella spp. DNA in patients with suspected cat-scratch disease. (17624560)
2007
16
Role of magnetic resonance imaging and scintigraphy in the diagnosis and follow-up of osteomyelitis in cat-scratch disease. (17635689)
2007
17
Effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease. (17174500)
2007
18
Cat scratch disease during etanercept therapy. (17337229)
2007
19
Somatostatin receptor scintigraphy in patients with cat-scratch disease. (16964341)
2006
20
Epidemiology of cat-scratch disease hospitalizations among children in the United States. (16094224)
2005
21
Papillary vasoproliferative changes in cat scratch disease. (15615761)
2005
22
Disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess. (16351038)
2005
23
Cat scratch disease: an unusual cause of facial palsy and partial ptosis: case report. (15944991)
2005
24
Cat-scratch disease (ocular bartonellosis) presenting as bilateral recurrent iridocyclitis. (15714406)
2005
25
Development of IgA nephritis following cat scratch disease in a 13-year-old boy. (15015065)
2004
26
Neck abscess secondary to cat-scratch disease. (15628637)
2004
27
Cat-scratch disease occurring in three siblings simultaneously. (12797315)
2003
28
Isolated splenic cat scratch disease. (12955654)
2003
29
Cat-scratch disease presenting as a solitary tumour in the breast: report of three cases. (12551788)
2003
30
From the Centers for Disease Control and Prevention. Cat-Scratch Disease in children--Texas, September 2000-August 2001. (12035788)
2002
31
Enzyme immunoassay for the diagnosis of cat-scratch disease defined by polymerase chain reaction. (11692296)
2001
32
Isolation in endothelial cell cultures of chlamydia trachomatis LGV (Serovar L2) from a lymph node of a patient with suspected cat scratch disease. (10834954)
2000
33
Transverse myelitis associated with probable cat-scratch disease in a previously healthy pediatric patient. (10987731)
2000
34
Prevalence of antibodies to Bartonella henselae in patients with suspected cat scratch disease (CSD) in Italy. (10485354)
1999
35
Cat-scratch disease encephalopathy: a cause of status epilepticus in school-aged children. (10228301)
1999
36
Palatal nerve palsy and cervical adenopathy in a probable case with cat scratch disease. (10745340)
1999
37
Recurrent encephalopathy in cat-scratch disease. (10391197)
1999
38
Cat-scratch disease in a patient undergoing haemodialysis. (9141021)
1997
39
Detection of antibodies to Bartonella henselae in clinically diagnosed cat scratch disease. (9196486)
1997
40
Molecular diagnosis of cat scratch disease: a two-step approach. (9230357)
1997
41
Etiology of cat-scratch disease. (8623713)
1996
42
Cat-scratch disease in Italy: a serological approach. (7526131)
1994
43
Cat scratch disease. (22050145)
1994
44
Disseminated hepatic and splenic calcifications following cat-scratch disease. (7824370)
1994
45
Cat scratch disease: past and present. (7532423)
1994
46
Oculoglandular syndrome. Cat-scratch disease without the cat scratch. (1561160)
1992
47
Cat-scratch disease: therapy with trimethoprim-sulfamethoxazole. (1558070)
1992
48
Disseminated cat-scratch disease simulating neuroblastoma. (1461700)
1992
49
Multiple scattered granulomatous skin lesions in cat scratch disease. (1521488)
1992
50
Cerebral arteritis in cat-scratch disease. (573385)
1979

Variations for Cat-Scratch Disease

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Expression for genes affiliated with Cat-Scratch Disease

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Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for genes affiliated with Cat-Scratch Disease

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Pathways related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3CS, HSPD1
29.0CORO1A, EEA1, HSPD1

GO Terms for genes affiliated with Cat-Scratch Disease

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Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1early endosomeGO:00057699.3CORO1A, EEA1, HSPD1
2extracellular exosomeGO:00700628.0CORO1A, CS, EEA1, HSPD1, HTRA1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:00327359.9CD40LG, HSPD1
2positive regulation of interleukin-10 productionGO:00327339.9CD40LG, HSPD1
3positive regulation of T cell activationGO:00508709.7CORO1A, HSPD1
4B cell proliferationGO:00421009.7CD40LG, HSPD1
5positive regulation of T cell proliferationGO:00421029.4CD40LG, CORO1A
6negative regulation of neuron apoptotic processGO:00435249.4CORO1A, HSPD1

Sources for Cat-Scratch Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet