MCID: CTS002
MIFTS: 37

Cat-Scratch Disease malady

Infectious, Immune categories

Summaries for Cat-Scratch Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Cat scratch disease (csd) is an illness caused by the bacterium bartonella henselae. almost half of all cats carry the infection at some point. the infection does not make cats sick. however, the scratch or bite of an infected cat can cause symptoms in people, including swollen lymph nodes, especially around the head, neck, and upper limbs fever headache fatigue poor appetite for people with weak immune systems, csd may cause more serious problems. the best way to avoid csd is to avoid rough play with cats that could lead to scratches or bites. if you do get a scratch or bite, wash it well with soap and water. if the bite or scratch gets infected or if you have symptoms of csd, call your doctor. centers for disease control and prevention

MalaCards: Cat-Scratch Disease, also known as bartonellosis due to bartonella henselae infection, is related to tuberculosis and neuroretinitis, and has symptoms including regional lymphadenopathy, headache and chills. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA serine peptidase 1), and among its related pathways are Pyruvate metabolism and Citric acid cycle (TCA cycle). Affiliated tissues include lymph node, lymph node and skin.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in lymph node, has material basis in bartonella henselae or has material basis in bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. the infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

NIH Rare Diseases:43 Cat scratch disease is an infectious illness caused by the bacteria bartonella. it is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. this self-limiting infectious disease is characterized by swelling and pain in the lymph nodes. although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may speed recovery. last updated: 3/4/2009

CDC:3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión's disease, caused by B. bacilliformis.

Wikipedia:64 Cat scratch disease (CSD), also known as cat scratch fever,Teeny\'s Disease,inoculation... more...

Aliases & Classifications for Cat-Scratch Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Immune


Characteristics (Orphanet epidemiological data):

49
cat-scratch disease:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

cat-scratch disease 8 10 49 31 61
bartonellosis due to bartonella henselae infection 43 49
cat scratch disease 43 34
cat scratch fever 8 43
debre's syndrome 8 61
foshay-mollaret cat scratch fever 8
benign lymphoreticulosis 8
debre-mollaret syndrome 8


External Ids:

Disease Ontology8 DOID:11258
MeSH35 D002372
NCIt40 C84620
ICD9CM27 078.3
UMLS via Orphanet62 C0007361
MESH via Orphanet36 D002372
ICD10 via Orphanet26 A28.1
SNOMED-CT via Orphanet58 79974007
ICD1025 A28.1

Related Diseases for Cat-Scratch Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to cat-scratch disease

Clinical Features for Cat-Scratch Disease

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • regional lymphadenopathy
  • headache
  • chills
  • backache
  • abdominal pain

Drugs & Therapeutics for Cat-Scratch Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cat-Scratch Disease

Drug clinical trials:

Search ClinicalTrials for Cat-Scratch Disease

Search NIH Clinical Center for Cat-Scratch Disease

Search CenterWatch for Cat-Scratch Disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Cat-Scratch Disease:

33
Lymph node, Skin

FMA organs/tissues related to Cat-Scratch Disease:

14
Lymph node

Animal Models for Cat-Scratch Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Cat-Scratch Disease

Sources:
51PubMed
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Articles related to Cat-Scratch Disease:

idTitleAuthorsYear
1
Cat-scratch disease in Northern Italy: atypical clinical manifestations in humans and prevalence of Bartonella infection in cats. (23132688)
2013
2
Cat scratch disease. Survey on the presence of Bartonella henselae among cats of Tuscany. (12173772)
2002
3
Two different genotypes of Bartonella henselae in children with cat-scratch disease and their pet cats. (9817520)
1998
4
Prevalence of antibodies to Rochalimaea species (cat-scratch disease agent) in cats. (7544936)
1995
5
Prolonged Bartonella bacteremia in cats associated with cat-scratch disease patients. (8586710)
1995

Genetic Variations for Cat-Scratch Disease

Expression for genes affiliated with Cat-Scratch Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for genes affiliated with Cat-Scratch Disease

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Cat-Scratch Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7DLST, CS
2
Hide members
9.7DLST, CS

Compounds for genes affiliated with Cat-Scratch Disease

GO Terms for genes affiliated with Cat-Scratch Disease

Sources:
16Gene Ontology
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Cellular components related to Cat-Scratch Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1SDCBP, EEA1, AGL, HTRA1, EXOSC5, RPL4
2cytoplasmGO:0057376.3SDCBP, RPL4, EXOSC5, UBASH3B, PPP1R14A, AGL

Biological processes related to Cat-Scratch Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of JNK cascadeGO:0463309.5SDCBP, TNF
2tricarboxylic acid cycleGO:0060999.4DLST, CS

Products for genes affiliated with Cat-Scratch Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cat-Scratch Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet