MCID: CTS002
MIFTS: 51

Cat-Scratch Disease malady

Infectious diseases, Immune diseases categories

Summaries for Cat-Scratch Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cat scratch disease (csd) is an illness caused by the bacterium bartonella henselae. almost half of all cats carry the infection at some point. the infection does not make cats sick. however, the scratch or bite of an infected cat can cause symptoms in people, including swollen lymph nodes, especially around the head, neck, and upper limbs fever headache fatigue poor appetite for people with weak immune systems, csd may cause more serious problems. the best way to avoid csd is to avoid rough play with cats that could lead to scratches or bites. if you do get a scratch or bite, wash it well with soap and water. if the bite or scratch gets infected or if you have symptoms of csd, call your doctor. centers for disease control and prevention

MalaCards: Cat-Scratch Disease, also known as bartonellosis due to bartonella henselae infection, is related to endocarditis and tuberculosis, and has symptoms including backache, regional lymphadenopathy and abdominal pain. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA serine peptidase 1), and among its related pathways are Pyruvate metabolism and Citric acid cycle (TCA cycle). Affiliated tissues include lymph node, lymph node and skin.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in lymph node, has material basis in bartonella henselae or has material basis in bartonella clarridgeiae, which are transmitted by scratch or bite of a kitten, or transmitted by contact of animal's saliva with an eye or through broken skin. the infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

NIH Rare Diseases:42 Cat scratch disease is an infectious illness caused by the bacteria bartonella. it is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. this self-limiting infectious disease is characterized by swelling and pain in the lymph nodes. although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may speed recovery. last updated: 3/4/2009

CDC:3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión's disease, caused by B. bacilliformis.

Wikipedia:63 Cat scratch disease (CSD), also known as cat scratch fever,Teeny\'s Disease,inoculation... more...

Aliases & Classifications for Cat-Scratch Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Characteristics (Orphanet epidemiological data):

48
cat-scratch disease:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

cat-scratch disease 8 10 48 60
bartonellosis due to bartonella henselae infection 42 48
cat scratch disease 42 33
cat scratch fever 8 42
debre's syndrome 8 60
foshay-mollaret cat scratch fever 8
benign lymphoreticulosis 8
debre-mollaret syndrome 8


External Ids:

Disease Ontology8 DOID:11258
MeSH34 D002372
NCIt39 C84620
ICD9CM27 078.3
UMLS via Orphanet61 C0007361
MESH via Orphanet35 D002372
ICD10 via Orphanet26 A28.1
SNOMED-CT via Orphanet57 79974007
ICD1025 A28.1

Related Diseases for Cat-Scratch Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to cat-scratch disease

Clinical Features for Cat-Scratch Disease

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Sources:
8Disease Ontology
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Symptoms:

8
  • backache
  • regional lymphadenopathy
  • abdominal pain
  • chills
  • headache

Drugs & Therapeutics for Cat-Scratch Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cat-Scratch Disease

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Anatomical Context for Cat-Scratch Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Cat-Scratch Disease:

32
Lymph node, Skin, Eye, Bone, Testes, Breast, Bone marrow, Liver, Spleen, Kidney, Monocytes, T cells, Endothelial, Colon

FMA organs/tissues related to Cat-Scratch Disease:

14
Lymph node

Animal Models for Cat-Scratch Disease or affiliated genes

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Publications for Cat-Scratch Disease

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Sources:
50PubMed
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Articles related to Cat-Scratch Disease:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Evaluation of IgG ELISA using N-lauroyl-sarcosine-soluble proteins of Bartonella henselae for highly specific serodiagnosis of cat scratch disease. (22902161)
2012
2
Optic neuropathy and cat scratch disease. (21779676)
2011
3
Seasonality of cat-scratch disease, France, 1999-2009. (21470466)
2011
4
Bone pain and fever in an adolescent and his sibling. Cat scratch disease (CSD). (21513084)
2011
5
Cat-scratch disease: ocular manifestations and visual outcome. (20668914)
2010
6
Optic neuropathy secondary to cat scratch disease: case report. (21271032)
2010
7
Systemic cat scratch disease. (16935770)
2006
8
Ocular manifestation of cat-scratch disease in HIV-positive patients. (16458711)
2006
9
Disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess. (16351038)
2005
10
Cat scratch disease: an unusual cause of facial palsy and partial ptosis: case report. (15944991)
2005
11
Cat scratch disease mimicking Richter's Syndrome in a patient with chronic lymphocytic leukemia. (15621836)
2005
12
Optic neuropathy secondary to cat scratch disease: distinguishing MR imaging features from other types of optic neuropathies. (15956488)
2005
13
Macular hole in cat scratch disease. (16038666)
2005
14
Cat-scratch disease presenting as a breast mass. (15307578)
2004
15
Evaluation of indirect fluorescence antibody assay for detection of Bartonella clarridgeiae and Seroprevalence of B. clarridgeiae among patients with suspected cat scratch disease. (15243113)
2004
16
Genetic variation of Bartonella henselae detected in lymph nodes from patients with cat scratch disease in Slovenia. (12860661)
2003
17
Cat-scratch disease osteomyelitis. (12525945)
2003
18
Primary lesion of cat-scratch disease and inguinal cat-scratch disease. (12674683)
2003
19
Cat scratch disease with lymphadenitis, vertebral osteomyelitis, and spleen abscesses. (12860662)
2003
20
Cat or dog ownership and seroprevalence of ehrlichiosis, Q fever, and cat-scratch disease. (14609477)
2003
21
Cat-scratch disease in an immunocompromised host. (11887039)
2002
22
Probable atypical cat scratch disease presenting as isolated posterior pancreatic duodenal lymphadenitis and abdominal pain. (11512100)
2001
23
Cat-scratch disease: epidemiology, aetiology and treatment. (11440202)
2001
24
Clinical and angiographic characteristics of retinal manifestations in cat scratch disease. (10715390)
2000
25
Detection of Bartonella henselae and Afipia felis DNA by polymerase chain reaction in specimens from patients with cat scratch disease. (11205638)
2000
26
Polymerase chain reaction detection of Bartonella henselae bacteraemia in an immunocompetent child with cat-scratch disease. (10834521)
2000
27
Cat-scratch disease with paravertebral mass and osteomyelitis. (10064243)
1999
28
Hepatosplenic cat-scratch disease in children: selected clinical features and treatment. (10825038)
1999
29
Atypical mass lesion associated with cat-scratch disease. (10433602)
1999
30
A case of cat scratch disease masquerading as lymphogranuloma venereum. (10361925)
1999
31
Management of B. henselae neuroretinitis in cat-scratch disease. (9917766)
1999
32
Conservative management of documented neuroretinitis in cat scratch disease associated with Bartonella henselae infection. (10379716)
1999
33
Serologic response to Bartonella henselae in patients with cat scratch disease and in sick and healthy children. (10229038)
1999
34
Radiological case of the month. Cat-scratch disease with hepatic and splenic involvement. (9701150)
1998
35
Cat-scratch disease osteomyelitis from a dog scratch. (9768882)
1998
36
Cat-scratch disease in a patient undergoing haemodialysis. (9141021)
1997
37
Detection of antibodies to Bartonella henselae in clinically diagnosed cat scratch disease. (9196486)
1997
38
Prevalence of Bartonella henselae bacteremia, the causative agent of cat scratch disease, in an Australian cat population. (8912359)
1996
39
Cat scratch disease presenting as multifocal osteitis. (8757779)
1996
40
Systemic cat-scratch disease presenting as leukocytoclastic vasculitis. (8684888)
1996
41
Bartonella henselae is a causative agent of cat scratch disease in Australia. (8586847)
1995
42
Characterization of a 17-kilodalton antigen of Bartonella henselae reactive with sera from patients with cat scratch disease. (7494028)
1995
43
From the Centers for Disease Control and Prevention. Encephalitis associated with cat scratch disease--Broward and Palm Beach counties, Florida, 1994. (7531250)
1995
44
Cat-scratch disease in Italy: a serological approach. (7526131)
1994
45
Cat-scratch disease encephalopathy. (8194375)
1994
46
Positive predictive value of Rochalimaea henselae antibodies in the diagnosis of cat-scratch disease. (7527255)
1994
47
Conjunctival swab to diagnose ocular cat scratch disease. (8053472)
1994
48
Cat scratch disease and bacillary angiomatosis: aetiological agents and the link with AIDS. (7693166)
1993
49
Intracellular growth of Afipia felis, a putative etiologic agent of cat scratch disease. (1587595)
1992
50
Isolation of agent associated with cat scratch disease bacillus from pretibial biopsy. (1802540)
1991

Genetic Variations for Cat-Scratch Disease

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Expression for genes affiliated with Cat-Scratch Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cat-Scratch Disease

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Pathways for genes affiliated with Cat-Scratch Disease

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Cat-Scratch Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7DLST, CS
2
Hide members
9.7DLST, CS

Compounds for genes affiliated with Cat-Scratch Disease

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GO Terms for genes affiliated with Cat-Scratch Disease

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Sources:
16Gene Ontology
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Cellular components related to Cat-Scratch Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1SDCBP, EEA1, AGL, HTRA1, EXOSC5, RPL4
2cytoplasmGO:0057376.3SDCBP, RPL4, EXOSC5, UBASH3B, PPP1R14A, AGL

Biological processes related to Cat-Scratch Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of JNK cascadeGO:0463309.5SDCBP, TNF
2tricarboxylic acid cycleGO:0060999.4DLST, CS

Products for genes affiliated with Cat-Scratch Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cat-Scratch Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet