MCID: CTS002
MIFTS: 45

Cat-Scratch Disease

Categories: Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Cat-Scratch Disease

MalaCards integrated aliases for Cat-Scratch Disease:

Name: Cat-Scratch Disease 12 56 42 14 69
Cat Scratch Disease 50 41 3
Bartonellosis Due to Bartonella Henselae Infection 50 56
Cat Scratch Fever 12 50
Debre's Syndrome 12 69
Foshay-Mollaret Cat Scratch Fever 12
Benign Lymphoreticulosis 12
Debre-Mollaret Syndrome 12
Oroya Fever 69

Characteristics:

Orphanet epidemiological data:

56
cat-scratch disease
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11258
ICD10 33 A28.1
ICD9CM 35 078.3
MeSH 42 D002372
NCIt 47 C84620
Orphanet 56 ORPHA50839
MESH via Orphanet 43 D002372
UMLS via Orphanet 70 C0007361 C0238909
ICD10 via Orphanet 34 A28.1
UMLS 69 C0007361

Summaries for Cat-Scratch Disease

MedlinePlus : 41 cat scratch disease (csd) is an illness caused by the bacterium bartonella henselae. almost half of all cats carry the infection at some point. the infection does not make cats sick. however, the scratch or bite of an infected cat can cause symptoms in people, including swollen lymph nodes, especially around the head, neck, and upper limbs fever headache fatigue poor appetite for people with weak immune systems, csd may cause more serious problems. the best way to avoid csd is to avoid rough play with cats that could lead to scratches or bites. if you do get a scratch or bite, wash it well with soap and water. if the bite or scratch gets infected or if you have symptoms of csd, call your doctor. centers for disease control and prevention

MalaCards based summary : Cat-Scratch Disease, also known as cat scratch disease, is related to bartonellosis and lymphoma, and has symptoms including fever and pruritus. An important gene associated with Cat-Scratch Disease is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Tuberculosis. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and eye.

Disease Ontology : 12 A bartonellosis that results_in infection located in lymph node, has material basis in Bartonella henselae or has material basis in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has symptom regional lymphadenopathy, has symptom headache, has symptom chills, has symptom backache, and has symptom abdominal pain.

NIH Rare Diseases : 50 cat scratch disease is an infectious illness caused by the bacteria bartonella (bartonella henselae). it is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. this self-limiting infectious disease is characterized by a bump or blister at the site of the bite or scratch and swelling and pain in the lymph nodes. other features may include fatigue, headache, achiness, and fever. although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may help speed recovery. last updated: 7/20/2016

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia : 72 Cat-scratch disease (CSD) is a common and usually benign infectious disease caused by the bacterium... more...

Related Diseases for Cat-Scratch Disease

Diseases related to Cat-Scratch Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 bartonellosis 32.5 CD40LG IFNG
2 lymphoma 30.3 CD40LG IFNG
3 chlamydia 26.0 CD40LG CORO1A CS EEA1 HSPD1 HTRA1
4 neuroretinitis 11.4
5 trench fever 11.3
6 intermediate uveitis 11.3
7 diarrhea 3, secretory sodium, congenital, syndromic 11.0
8 pars planitis 11.0
9 carrion's disease 11.0
10 chronic duodenal ileus 10.5 CD40LG HTRA1
11 psychologic dyspareunia 10.4 HTRA1 IFNG
12 indian tick typhus 10.4 CD40LG IFNG
13 tick-borne encephalitis 10.4 CD40LG EEA1
14 dumping syndrome 10.4 CD40LG IFNG
15 leiomyosarcoma 10.4 CD40LG HSPD1
16 pancreatic vasoactive intestinal peptide producing tumor 10.4 CD40LG HSPD1
17 basilar artery occlusion 10.4 CD40LG HSPD1
18 centronuclear myopathy 5 10.4 CD40LG IFNG
19 mineral metabolism disease 10.4 CD40LG HSPD1
20 tularemia 10.4 CD40LG IFNG
21 hepadnavirus infection 10.4 CD40LG IFNG
22 osteomyelitis 10.4
23 tuberculoid leprosy 10.4 CD40LG HSPD1
24 acute vascular insufficiency of intestine 10.4 CD40LG IFNG
25 encephalopathy 10.4
26 restless legs syndrome 10.4 CD40LG HSPD1
27 conduct disorder 10.3 CD40LG IFNG
28 cutaneous fibrous histiocytoma 10.3 CD40LG IFNG
29 compensatory emphysema 10.3 CD40LG HSPD1
30 membranoproliferative glomerulonephritis 10.3 CD40LG IFNG
31 specific developmental disorder 10.3 CD40LG IFNG
32 disease of mental health 10.3 CD40LG IFNG
33 motor peripheral neuropathy 10.3 CD40LG IFNG
34 angiomatosis 10.3
35 central nervous system origin vertigo 10.3 CD40LG IFNG
36 esophagus melanoma 10.3 CD40LG IFNG
37 retinitis 10.3
38 hepatitis 10.3
39 dermatitis herpetiformis, familial 10.3 CD40LG IFNG
40 dentinogenesis imperfecta 10.3 CD40LG IFNG
41 japanese spotted fever 10.3 HSPD1 IFNG
42 left bundle branch hemiblock 10.3 CD40LG IFNG
43 lymphadenitis 10.3
44 heart sarcoma 10.3 CD40LG IFNG
45 pulmonary tuberculosis 10.3 CD40LG IFNG
46 uterine adnexa cancer 10.3 CD40LG HSPD1
47 dracunculiasis 10.3 CD40LG CS
48 acute interstitial pneumonia 10.2 CD40LG IFNG
49 lymphoma, malt, somatic 10.2 CD40LG HSPD1
50 hypervitaminosis d 10.2 CD40LG IFNG

Graphical network of the top 20 diseases related to Cat-Scratch Disease:



Diseases related to Cat-Scratch Disease

Symptoms & Phenotypes for Cat-Scratch Disease

UMLS symptoms related to Cat-Scratch Disease:


fever, pruritus

Drugs & Therapeutics for Cat-Scratch Disease

Drugs for Cat-Scratch Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Gentamicins Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo

Search NIH Clinical Center for Cat-Scratch Disease

Cochrane evidence based reviews: cat-scratch disease

Genetic Tests for Cat-Scratch Disease

Anatomical Context for Cat-Scratch Disease

MalaCards organs/tissues related to Cat-Scratch Disease:

39
Lymph Node, Skin, Eye, Bone, Testes, Breast, Liver

Publications for Cat-Scratch Disease

Articles related to Cat-Scratch Disease:

(show top 50) (show all 561)
id Title Authors Year
1
Cat-Scratch Disease: A Pitfall for Lymphoma Evaluation by FDG-PET/CT. ( 27997427 )
2017
2
Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease. ( 28669017 )
2017
3
Cat scratch disease. Onset as epithroclear tumor. ( 28416228 )
2017
4
A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease. ( 28935172 )
2017
5
Cat scratch disease: U.S. clinicians' experience and knowledge. ( 28707827 )
2017
6
Cat scratch disease during etanercept therapy in a rheumatoid arthritis patient. ( 28256443 )
2017
7
Cat Scratch Disease: Not a Benign Condition. ( 28665750 )
2017
8
Diverse Clinical Signs of Ocular Involvement in Cat Scratch Disease. ( 28182175 )
2017
9
Disseminated cat-scratch disease presenting as nausea, diarrhea, and weight loss without fever in a heart transplant recipient. ( 28199763 )
2017
10
The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease. ( 28029424 )
2016
11
Corticosteroid Treatment for Prolonged Fever in Hepatosplenic Cat-Scratch Disease. ( 28006985 )
2016
12
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report. ( 27662446 )
2016
13
Cat scratch disease in 9-year-old patient - a case report. ( 27213258 )
2016
14
Cat Scratch Disease: Expanded Spectrum. ( 27843905 )
2016
15
Cat-Scratch Disease in the United States, 2005-2013. ( 27648778 )
2016
16
Disseminated cat-scratch disease: case report and review of the literature. ( 27077606 )
2016
17
Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N-Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease. ( 26865692 )
2016
18
Cat-scratch disease with hepatosplenic lesions in two brothers. ( 27051576 )
2016
19
Cat Scratch Disease in a Renal Transplant Recipient. ( 27312684 )
2016
20
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2016
21
Atypical Cat Scratch Disease With Hepatosplenic Involvement. ( 27484614 )
2016
22
Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. ( 27193359 )
2016
23
Disseminated cat-scratch disease in an adult with selective IgA deficiency. ( 27257449 )
2016
24
Choroidal neovascularisation as an unusual ophthalmic manifestation of cat-scratch disease in an 8-year-old girl. ( 26135983 )
2015
25
Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease. ( 26576306 )
2015
26
Progressive Cat Scratch Disease Despite Antimicrobial Therapy. ( 26407443 )
2015
27
Cat-scratch disease with severe pleuritis in a 6-year-old girl. ( 26113319 )
2015
28
Evaluation of Cat Scratch Disease Cases Reported from Turkey between 1996 and 2013 and Review of the Literature. ( 26851430 )
2015
29
Cat-scratch disease presenting as a solitary splenic abscess in an elderly man. ( 25804947 )
2015
30
Persistent cat scratch disease requiring surgical excision in a patient with MPGN. ( 25963015 )
2015
31
Multiple Renal and Splenic Lesions in a Child with Cat Scratch Disease. ( 26567841 )
2015
32
Cat-Scratch Disease: Case Report and Review of the Literature. ( 26361690 )
2015
33
Disseminated cat-scratch disease: case report and review of the literature. ( 25940800 )
2015
34
Renal Microabscesses: A Presentation of Cat Scratch Disease. ( 25799194 )
2015
35
Status Epilepticus Due to Cat Scratch Disease: Recognition, Diagnosis, and Thoughts on Pathogenesis. ( 25853722 )
2015
36
New-onset refractory status epilepticus in an adult with an atypical presentation of cat-scratch disease: successful treatment with high-dose corticosteroids. ( 26044784 )
2015
37
Cat-scratch disease: a wide spectrum of clinical pictures. ( 26161064 )
2015
38
Cat scratch disease in an immunosuppressed patient with systemic lupus erythematosus. ( 26453661 )
2015
39
Cat scratch disease of the parotid gland. ( 26403943 )
2015
40
Posterior segment involvement in cat-scratch disease: A case series. ( 26545331 )
2015
41
Sonography of cat scratch disease. ( 25715359 )
2015
42
Hepatosplenic Cat-Scratch Disease in Children and the Positive Contribution of 18F-FDG Imaging. ( 26164171 )
2015
43
Cat scratch disease during infliximab therapy: a case report and literature review. ( 25547623 )
2015
44
Atypical manifestation of cat-scratch disease: isolated epigastric pain in an immunocompetent, 12-year-old child. ( 26273467 )
2015
45
Cat scratch disease. ( 25199244 )
2014
46
An uncommon cause of linfadenopathy in a kidney transplant patient: cat-scratch disease. ( 25036076 )
2014
47
Molecular identification of Bartonella henselae in a seronegative cat scratch disease patient with AIDS in Rio de Janeiro, Brazil. ( 25076441 )
2014
48
Hepatosplenic cat scratch disease in immunocompetent adults: report of 3 cases and review of the literature. ( 25803522 )
2014
49
Cat-scratch-disease-associated macular oedema treated with intravitreal ranibizumab. ( 24943325 )
2014
50
Cat scratch disease in MedellA-n, Colombia. ( 25988023 )
2014

Variations for Cat-Scratch Disease

Expression for Cat-Scratch Disease

Search GEO for disease gene expression data for Cat-Scratch Disease.

Pathways for Cat-Scratch Disease

Pathways related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CD40LG IFNG
2 11.18 CORO1A EEA1 HSPD1 IFNG
3
Show member pathways
11.12 CD40LG IFNG
4 11.05 CS HSPD1
5 10.85 CD40LG IFNG
6 10.47 CD40LG IFNG

GO Terms for Cat-Scratch Disease

Cellular components related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 8.8 CORO1A EEA1 HSPD1

Biological processes related to Cat-Scratch Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 movement of cell or subcellular component GO:0006928 9.37 CORO1A IFNG
2 B cell proliferation GO:0042100 9.32 CD40LG HSPD1
3 positive regulation of T cell activation GO:0050870 9.26 CORO1A HSPD1
4 positive regulation of interleukin-10 production GO:0032733 9.16 CD40LG HSPD1
5 positive regulation of T cell proliferation GO:0042102 9.13 CD40LG CORO1A IFNG
6 positive regulation of interleukin-12 production GO:0032735 8.8 CD40LG HSPD1 IFNG

Sources for Cat-Scratch Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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