Cataract malady

MedlinePlus: A cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all people in the united states either have a cataract or have had cataract surgery. common symptoms are blurry vision colors that seem faded glare not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute²³

MalaCards: Cataract, also known as bilateral cataracts (disorder), is related to congenital cataracts and senile cataract. An important gene associated with Cataract is GJA8 (gap junction protein, alpha 8, 50kDa), and among its related pathways are Inhibition of Angiogenesis by TSP1 and Metabolic pathways. The compounds lipid and thymidine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are mortality/aging and integument.

Wikipedia: A cataract is a clouding of the lens inside eye associated with a reduction in vision. It is the most...⁴⁴ more...

Aliases & Descriptions:

cataract 6 7 17 32 23 bilateral cataracts (disorder) 43

cataracts 7

Diseases related to cataract by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1080)

id	Related Disease	Score	Top Affiliating Genes
1	congenital cataracts	39.8	GCNT2, BFSP2, PAX6, MIP, MAF, EYA1
2	senile cataract	36.6	SERPINF1, BFSP1, LAMA3, FUCA1, MIP, GSR
3	diabetic cataract	35.6	SERPINF1, VARS, MIP, GSR, FAM19A1, FAM46D
4	hyperferritinemia-cataract syndrome	35.4	FTL, CRP, ACO1, HFE, TF, WNT2
5	posterior polar cataract	34.8	SEPT2, BFSP1, AQP12B, MAFB, GJA3, CTPP
6	microphthalmia	34.3	VSX2, GCNT2, RAB3GAP1, RAX, RAB3GAP2, RAB18
7	cerulean cataract	34.1	MIP, MAF, CRYBB2, CRYBB2P1, CRYBB3, CRYGB
8	cataract microcornea syndrome	32.3	MAF, GJA8, CRYAA, CRYBB1
9	cataract-glaucoma	32.3	PAX6, FOXC1, GSR, AKR1B1, GJA1, OTX2
10	cataract, zonular	32.2	HSF4, GJA3, GJA8, CRYAA, CRYBA1, CRYBA4
11	aniridia	32.0	PAX6, ATP2A2, FOXC1, FOXE3, CAT, OTX2
12	microphthalmia cataract	31.7	VSX2, CATM, GJA1, CRYBA4, SIX6
13	mature cataract	31.7	XPNPEP1, DYNLL1, SORD, SLC23A1, GAPDH
14	muscular dystrophy	31.2	SGCB, LMNA, MYOT, LOC619409, CAPN2, DMD
15	cataracts, autosomal dominant	31.2	GJA8, CRYAA, CRYBB1, CRYBB2
16	coloboma	30.8	VSX2, RAX, PAX6, BCOR, LCA5, FOXE3
17	optic atrophy	30.3	RAB3GAP1, RAB3GAP2, RAB18, AUH, IGF1, GJA1
18	cataract, pulverulent	30.2	VIM, MAF, CTPL1, CRYBB1
19	glaucoma	30.1	VSX2, GCNT2, SERPINF1, VEGFA, BMP6, BEST1
20	myopathy	29.8	SGCB, CNBP, VIM, LMNA, MYOT, BLZF1
21	hearing loss	29.5	RAB3GAP1, CLCN1, SCN4A, MTHFR, ATP7A, ATP7B
22	keratoconus	29.4	SERPINF1, VIM, KCNJ13, CIB2, MTHFS, MMP3
23	neuropathy	29.3	SERPINF1, VIM, NAGLU, VEGFA, LMNA, MYOT
24	myotonic dystrophy type 1	29.2	CNBP, CLCN1, ATP2A3, ATP2A1, ATP2A2, MBNL1
25	rhizomelic chondrodysplasia punctata	29.1	MVK, GNPAT, CAT, PHYH, AGPS, PEX7
26	anophthalmia	29.0	VSX2, RAX, PAX6, BCOR, INS, EYA1
27	myotonic dystrophy	29.0	CNBP, VIM, LMNA, CLCN1, SCN4A, LEP
28	peters anomaly	28.7	PAX6, FOXC1, FOXE3, MAF, GJA8, CRYBB1
29	hypertrophic cardiomyopathy	28.4	SGCB, LMNA, MT-CYB, AUH, ATP2A2, CD36
30	ataxia	28.3	PCNA, VIM, VARS, RAI2, BLZF1, PARP1
31	microcephaly	28.1	RAB3GAP1, RAB3GAP2, RAB18, PAX6, BCOR, FTO
32	galactosemia	28.1	AKR1B1, G6PD, GALK1, GALT, GALE
33	stickler syndrome	28.0	SERPINF1, PAX6, FOXC1, PITX2, TKT, TGFB2
34	myofibrillar myopathy	27.9	LMNA, MYOT, BLZF1, DMD, CRYAB, DES
35	sensorineural hearing loss	27.9	GJB2, COL4A5, COL11A1, COL2A1, ACTG1, SOX2
36	exfoliation syndrome	27.7	MGST1, GSTM1, GSTT1, APOE, LOXL1, CAT
37	hypotonia	27.7	LMNA, PAX6, MVK, ATP7A, ATP7B, FH
38	keratopathy	27.5	PAX6, FN1, IL1A, FBN1, FAM46D, IGF1
39	alcoholism	27.4	GSR, IL1RN, GPT, HTR3A, ALDH9A1, AKR1A1
40	ophthalmoplegia	27.3	C10orf2, SOD2, POLG, POLG2, SLC25A4, CPOX
41	spasticity	27.2	VEGFA, RAB3GAP1, RAB3GAP2, RAB18, MTHFR, JAM3
42	lactic acidosis	27.1	SDHB, AUH, SOD2, POLG, CPOX, HADHA
43	bullous keratopathy	27.0	IL1A, FBN1, IGF1, TNC, TGFB1, TGFB2
44	myopathy congenital	27.0	LOC619409, DMD, DNAH8, DNM2, DES
45	hypoparathyroidism	26.8	NAGLU, MTHFR, INS, IGF1, CASR, CALCA
46	neurodegeneration	26.5	SERPINF1, VEGFA, BMP6, RAB18, BLZF1, PARP1
47	hypogonadism	26.3	RECQL4, LMNA, RAB3GAP1, RAB3GAP2, RAB18, CLCN1
48	diabetic neuropathy	26.3	VEGFA, PARP1, LEP, INS, GSTM1, GSTT1
49	sjogren's syndrome	26.2	PCNA, PARP1, LAMA3, MMP3, MIP, IL13
50	age related macular degeneration	26.1	SERPINF1, NAT2, VEGFA, BEST1, PARP1, CHRDL1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cataract:

²²

MGI Mouse Phenotypes related to cataract:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	INF	, , VSX2, PCMT1, NAGLU, VEGFA
2	integument phenotype	MP:0010771	INF	, GCNT2, CLCN1, PARP1, PAX6, KEAP1
3	homeostasis/metabolism phenotype	MP:0005376	INF	PCMT1, GCNT2, VIM, NAT2, VEGFA, LMNA
4	vision/eye phenotype	MP:0005391	INF	, , VSX2, SERPINF1, VIM, NAGLU
5	cellular phenotype	MP:0005384	INF	KLC1, , , PCNA, PCMT1, VIM
6	behavior/neurological phenotype	MP:0005386	INF	KLC1, PCMT1, GCNT2, VIM, NAGLU, LMNA
7	immune system phenotype	MP:0005387	INF	, SGCB, PCMT1, GCNT2, VIM, NAGLU
8	cardiovascular system phenotype	MP:0005385	INF	SGCB, SERPINF1, VIM, NAGLU, VEGFA, LMNA
9	no phenotypic analysis	MP:0003012	INF	VSX2, PCNA, VEGFA, MYOT, RAB18, CLCN1
10	skeleton phenotype	MP:0005390	INF	, PCMT1, NAGLU, VEGFA, , LMNA
11	reproductive system phenotype	MP:0005389	INF	VSX2, SERPINF1, VEGFA, LMNA, CLCN1, PAX6
12	normal phenotype	MP:0002873	INF	VEGFA, , LMNA, MYOT, , CLCN5
13	limbs/digits/tail phenotype	MP:0005371	INF	, VEGFA, , LMNA, LEP, UCHL1
14	tumorigenesis	MP:0002006	INF	, PAX6, LEP, MTHFS, XRCC1, ATP2A2
15	adipose tissue phenotype	MP:0005375	INF	LMNA, LEP, FTO, CD36, INS, FGFR2
16	pigmentation phenotype	MP:0001186	INF	, VSX2, SERPINF1, NAGLU, LMNA, BEST1
17	liver/biliary system phenotype	MP:0005370	INF	VEGFA, CLCN5, ATP7A, ATP7B, CD36, FOXC1
18	hearing/vestibular/ear phenotype	MP:0005377	INF	NAGLU, LMNA, CLCN1, PARP1, PAX6, IREB2
19	respiratory system phenotype	MP:0005388	10.5	PCMT1, PAX6, ATP7A, ATP2A1, JAM3, FOXC1
20	other phenotype	MP:0005395	9.5	KLC1, ATP7B, FOXC1, FN1, IL13, FBN1
21	craniofacial phenotype	MP:0005382	INF	, , NAGLU, , CLCN5, PAX6
22	nervous system phenotype	MP:0003631	INF	KLC1, , VSX2, SERPINF1, NAGLU,
23	endocrine/exocrine gland phenotype	MP:0005379	INF	VSX2, JAM3, FGFR2, MAFB, EYA1, GJA1
24	hematopoietic system phenotype	MP:0005397	INF	, PCNA, PCMT1, GCNT2, UCHL1, ATP7B
25	digestive/alimentary phenotype	MP:0005381	INF	, SERPINF1, VEGFA, LMNA, , PAX6
26	embryogenesis phenotype	MP:0005380	INF	, , VIM, , PARP1, PAX6
27	growth/size phenotype	MP:0005378	INF	KLC1, , SGCB, , PCMT1, NAGLU
28	renal/urinary system phenotype	MP:0005367	INF	GCNT2, NAGLU, LMNA, CLCN5, PAX6, UCHL1
29	muscle phenotype	MP:0005369	INF	SGCB, PCMT1, VIM, VEGFA, LMNA, CLCN1

Articles related to cataract:

(show top 50)    (show all 612)

id	Title	Authors	Year	Affiliating Genes
1	Cerulean cataract mapped to 12q13 and associated with a novel initiation codon mutation in MIP. (21850180)	Xiao X.... Zhang Q.	2011	MIP
2	A recurrent mutation in CRYGD is associated with auto somal dominant congenital coralliform cataract in two unrelated Chinese familie s. (21552497)	Yang G.... Zhao J.	2011	CRYGD
3	Mutation analysis of 12 genes in Chinese families wit h congenital cataracts. (21866213)	Sun W.... Zhang Q.	2011	CRYAB, CRYAA, CRYGD
4	Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts. (21268678)	Rudolph T.... Zetterberg M.	2011	UCHL1
5	A novel mutation in MIP associated with congenital nu clear cataract in a Chinese family. (21245956)	Wang K.J.... Zhu S.Q.	2011	MIP
6	A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. (20142846)	Gu Z.... Gao L.	2010	CRYBA1
7	Association of G>A transition in exon-1 of alpha c rystallin gene in age-related cataracts. (20606865)	Bhagyalaxmi S.G.... Reddy K.R.	2010	CRYAA
8	Identification of dominant FOXE3 and PAX6 mutations i n patients with congenital cataract and aniridia. (20806047)	BrAcmond-Gignac D.... Semina E.V.	2010	PAX6, FOXE3
9	Crystallin gene mutations in Indian families with inherited pediatric cataract. (18587492)	Devi R.R.... Hejtmancik J.F.	2008	CRYAA, CRYBA4, CRYBA1
10	A novel missense mutation in MIP gene resulted in po lymorphic cataract (18247294)	Lin H.... Qi Y.	2008	MIP
11	A nonsense mutation in CRYGC associated with autosomal dominant congenital nuclear cataract in a Chinese family. (18618005)	Yao K.... Shentu X.	2008	CRYGC
12	Changes in erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and reduced glutathione (GSH) activities in the development of senile and diabetic cataracts. (19058613)	Chandrasena L.G.... Peiris H.	2008	G6PD
13	A missense mutation in LIM2 causes autosomal recessive congenital cataract. (18596884)	Ponnam S.P.... Kannabiran C.	2008	LIM2
14	A missense mutation S228P in the CRYBB1 gene causes autosomal dominant congenital cataract. (17531125)	Wang J.... Zhu S.Q.	2007	CRYBB1
15	Recessive congenital total cataract with microcornea and heterozygote carrier signs caused by a novel missense CRYAA mutation (R54C). (17937925)	Khan A.O.... Meyer B.	2007	CRYAA
16	Prevalence of cataract in adult Down's syndrome patie nts aged 28 to 83 years. (18034878)	Puri B.K.... Singh I.	2007	SOD1
17	Congenital cataracts facial dysmorphism neuropathy syndrome--first Hungarian case report (17578274)	Siska E.... Molnar M.J.	2007	CTDP1
18	A novel alphaB-crystallin mutation associated with autosomal dominant congenital lamellar cataract. (16505043)	Liu Y.... Shang F.	2006	CRYAB
19	Hereditary hyperferritinemia cataract syndrome in three unrelated families of western Greek origin caused by the C39 > G mutation of L-ferritin IRE. (16406710)	Papanikolaou G.... Sakellaropoulos N.	2006	FTL
20	The congenital 'ant-egg' cataract phenotype is caused by a missense mutation in connexin46. (16971895)	Hansen L.... Rosenberg T.	2006	GJA3
21	Hyperferritinemia-cataract syndrome associated to the HFE gene mutation. Two new Spanish families and a new mutation (A37T: 'Zaragoza') (16900584)	Garcia Erce J.A.... Giralt M.	2006	TF, CRP, FTL
22	Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. (17240813)	Maurya O.P.... Chandra A.	2006	SOD1, CAT
23	Congenital cataracts-facial dysmorphism-neuropathy. (16939648)	Kalaydjieva L.	2006	CTDP1, POLR2L, DUSP19
24	A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. (16397066)	Arora A.... Berthoud V.M.	2006	GJA8
25	Congenital cataract, muscular hypotonia, developmental delay and sensorineural hearing loss associated with a defect in copper metabolism. (15902551)	HorvA!th R.... Jaksch M.	2005	SOD1, CP, ATP7A
26	Prevention of cataract by pyruvate in experimentally diabetic mice. (15786723)	Hegde K.R.... Varma S.D.	2005	AKR1B1
27	Cataracts in experimentally diabetic mouse: morphological and apoptotic changes. (15715894)	Hegde K.R.... Varma S.D.	2005	AKR1B1
28	CRYGD gene analysis in a family with autosomal dominant congenital cataract: evidence for molecular homogeneity and intrafamilial clinical heterogeneity in aculeiform cataract. (16030500)	Zenteno J.C.... Sanchez-Navarro A.	2005	CRYGD
29	Associations between plasma levels of vitamins and cataract in the Italian-American Clinical Trial of Nutritional Supplements and Age-Related Cataract (CTNS): CTNS Report #2. (16019690)	Ferrigno L.... Maraini G.	2005	CTNS
30	A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract. (15277496)	Smaoui N.... Hejtmancik J.F.	2004	HSF4
31	Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. (15452352)	Iyengar S.K.... Elston R.C.	2004	ARCC1
32	Synergistic transcription activation by Maf and Sox and their subnuclear localization are disrupted by a mutation in Maf that causes cataract. (15199128)	Rajaram N.... Kerppola T.K.	2004	MAF
33	Correlation of human age-related cataract with some blood biochemistry constituents. (14688423)	Mirsamadi M.... Nourmohammadi I.	2003	GPT
34	Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma. (11772997)	Jamieson R.V.... Black G.C.	2002	MAF
35	Ferritin crystal cataracts in hereditary hyperferritinemia cataract syndrome. (11923255)	Brooks D.G.... Stambolian D.	2002	FTL
36	Crystal cataracts: human genetic cataract caused by protein crystallization. (11371638)	Pande A.... Benedek G.B.	2001	CRYGD
37	Hereditary hyperferritinemia syndrome and cataract (11894536)	Feys J.... Beaumont C.	2001	TF
38	Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression. (10954416)	Duncan M.K.... Cvekl A.	2000	PAX6
39	Structural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataracts. (11123904)	Cobb B.A.... Petrash J.M.	2000	CRYAA
40	A point mutation in the bulge of the iron-responsive element of the L ferritin gene in two families with the hereditary hyperferritinemia-cataract syndrome. (9414300)	Martin M.E.... Beaumont C.	1998	FTL
41	Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse. (8812411)	Kerscher S.... Lyon M.F.	1996	LIM2
42	A novel mutation in the iron responsive element of ferritin L-subunit gene as a cause for hereditary hyperferritinemia-cataract syndrome. (8781450)	Aguilar-Martinez P.... Schved J.F.	1996	FTL
43	Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells. (8664236)	Nishi O.... Ohmoto Y.	1996	IL1R1, TGFB2
44	A progressive early onset cataract gene maps to human chromosome 17q24. (7704021)	Armitage M.M.... Ferrell R.E.	1995	CCA1
45	Hypomyelination and Congenita l Cataract (20301737)	Biancheri R.... Minetti C.	1993	FAM126A
46	Chromosome 14-terminal deletion and cataracts. (1497515)	Miller B.A.... Capo H.	1992	CTAA1
47	The possible mechanism of naphthalene cataract in rat and its prevention by an aldose reductase inhibitor (ALO1576). (1541342)	Xu G.T.... Lou M.F.	1992	AKR1B1
48	Characterization of a novel aldose reductase inhibito r, FR74366, and its effects on diabetic cataract and neuropathy in the rat. (1898618)	Ao S.... Yamaguchi I.	1991	AKR1B1
49	Metabolic studies of galactosemic cataract. (2209747)	Cheng H.M.... Tsubota K.	1990	AKR1B1
50	Cataract--clinic and pathology (2278235)	Fujinaga Y.	1990	SOD1

Genes related to cataract according to GeneCards:

(show top 50)    (show all 293)

id	Symbol	Description	Score	GeneCards Section Context
1	GJA8	gap junction protein, alpha 8, 50kDa	11.1	Summaries, Publications
2	CRYGD	crystallin, gamma D	11.1	Summaries, Publications
3	CRYBB2	crystallin, beta B2	11.1	Publications, Summaries
4	CRYAA	crystallin, alpha A	11.1	Summaries, Publications
5	MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	11.1	Summaries, Publications
6	GALK1	galactokinase 1	11.1	Publications, Summaries
7	PITX3	paired-like homeodomain 3	11.1	Publications, Summaries
8	BFSP2	beaded filament structural protein 2, phakinin	11.1	Summaries, Publications
9	GJA3	gap junction protein, alpha 3, 46kDa	11.1	Publications, Summaries
10	CRYGC	crystallin, gamma C	11.1	Publications, Summaries
11	CRYBA1	crystallin, beta A1	11.1	Summaries, Publications
12	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	11.1	Orthologs, Transcripts, Publications, Aliases & Descriptions
13	CRYGS	crystallin, gamma S	11.1	Publications, Summaries
14	BFSP1	beaded filament structural protein 1, filensin	11.1	Summaries, Publications
15	HSF4	heat shock transcription factor 4	11.1	Publications, Aliases & Descriptions
16	TDRD7	tudor domain containing 7	11.0	Publications, Summaries
17	FTL	ferritin, light polypeptide	11.0	Summaries, Publications
18	LIM2	lens intrinsic membrane protein 2, 19kDa	11.0	Summaries, Publications
19	EYA1	eyes absent homolog 1 (Drosophila)	11.0	Publications, Summaries
20	CTPL1	cataract, pulverulent (autosomal recessive, early-onset)	11.0	Publications, Aliases & Descriptions
21	CRYGB	crystallin, gamma B	11.0	Publications, Summaries
22	SIX6	SIX homeobox 6	11.0	Summaries
23	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	11.0	Aliases & Descriptions, Publications
24	CHMP4B	charged multivesicular body protein 4B	11.0	Publications, Summaries
25	EPHA2	EPH receptor A2	11.0	Summaries, Publications
26	CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	11.0	Publications, Summaries
27	JAM3	junctional adhesion molecule 3	11.0	Summaries, Publications
28	VIM	vimentin	11.0	Publications, Summaries
29	CCV	cataract, congenital, Volkmann type	11.0	Publications, Aliases & Descriptions
30	CATC3	Cataract, autosomal recessive congenital 3	11.0	Aliases & Descriptions
31	CRYGA	crystallin, gamma A	11.0	Publications, Summaries
32	FAM126A	family with sequence similarity 126, member A	11.0	Summaries, Publications
33	FYCO1	FYVE and coiled-coil domain containing 1	11.0	Summaries, Publications
34	ALDH18A1	aldehyde dehydrogenase 18 family, member A1	11.0	Publications, Summaries
35	ABHD12	abhydrolase domain containing 12	11.0	Summaries
36	SLC16A12	solute carrier family 16, member 12 (monocarboxylic acid transporter 12)	11.0	Summaries, Publications
37	CATM	cataract, congenital, with microphthalmia	11.0	Aliases & Descriptions
38	DFCTRPS	Deafness, cataract, retinitis pigmentosa, and sperm abnormalities	11.0	Aliases & Descriptions
39	CCT	cataract, congenital, total	11.0	Aliases & Descriptions
40	CTPP5	Cataract, posterior polar, 5	11.0	Aliases & Descriptions
41	CATCN1	cataract, congenital nuclear, autosomal recessive	11.0	Aliases & Descriptions, Publications
42	CCNP	Cataract, congenital, nuclear progressive	11.0	Aliases & Descriptions, Publications
43	CTPP	Cataract, posterior polar	11.0	Publications, Aliases & Descriptions
44	CCA1	cataract, congenital, cerulean type, 1	11.0	Aliases & Descriptions, Publications
45	CTAA1	cataract, anterior polar 1	11.0	Publications, Aliases & Descriptions
46	CCPSO	Cataract, central pouch-like, with sutural opacities	11.0	Publications, Aliases & Descriptions
47	ARCC1	Age-related cortical cataract 1	11.0	Aliases & Descriptions, Publications
48	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	11.0	Summaries, Publications
49	VSX2	visual system homeobox 2	11.0	Summaries
50	GALE	UDP-galactose-4-epimerase	11.0	Publications, Summaries

Pathways related to cataract according to GeneDecks:

(show top 50)    (show all 86)

id	Pathway	Score	Top Affiliating Genes
1	Inhibition of Angiogenesis by TSP136	INF	, COL4A5, TNC, CASP3, FBN1, FN1
2	Metabolic pathways20	INF	COMT, PPCS, CYP27A1, AKR1B10, AKR1B1, AKR1A1
3	Glutathione metabolism10	11.3	GGT1, GSTT1, GPX3, MGST1, GPX1, GSR
4	Glutathione metabolism41	11.2	GPX1, MGST1, GSR, GSS, GPX3, GSTM3
5	Cell adhesion Plasmin signaling10	10.0	TGFBR2, VEGFA, FN1, FGF2, PLAT, COL4A5
6	Hypertrophic cardiomyopathy (HCM)20	9.6	IL6, TNF, ATP2A2, LMNA, DMD, ACE
7	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.3	IL13, IL4, IL6, TGFB1, TGFB2, TGFB3
8	PPAR Pathway36	INF	FGFR2, GFER, FGF2, IGF1, NUDT6, LTBP1
9	p53 Mediated Apoptosis36	INF	TGFB2, IGF2, IGF1, FGFR2, CYCS, NUDT6
10	Pancreatic Adenocarcinoma36	INF	LTBP1, TGFB2, PTGS2, IGF1, IGF2, BMP6
11	Glutathione metabolism20	INF	GGT1, GSTM1, GPX1, GPX3, GSTM3,
12	Cellular Apoptosis Pathway36	INF	EGF, LTBP1, IL6, BMP6, FGF2, FGFR2
13	PTEN Pathway36	INF	TNC, FBN1, FGFR2, FGF2, FN1, LAMA3
14	Tec Kinases Signaling36	INF	FGFR2, IGF1, IGF2, MAPK10, IL6, IL4
15	Mitochondrial Apoptosis36	INF	GFER, TGFB1, TGFB2, TGFB3, PSIP1, SLC25A4
16	Renin-Angiotensin Pathway36	INF	EGFR, LTBP1, PTGS2, IGF1, IGF2, MAPK10
17	PAK Pathway36	INF	MYH9, IGF2, MAPK10, IL6, IL4, IL1A
18	14-3-3 Induced Intracellular Signaling36	INF	FGF2, , FGFR2, MAPK10, IGF1, TNF
19	ERK Signaling36	INF	LTBP1, IL6, , , EPHA2,
20	Pathways in cancer20	INF	VEGFA, FH, FGF2, FGFR2, MAPK10, CASP3
21	NF-KappaB (p50-p65) Pathway36	INF	BMP6, FGF2, PSIP1, EGF, EGFR, GFER
22	mTOR Pathway36	INF	NUDT6, TGFB2, INS, BMP6, FGF2, EPHA2
23	DHA Signaling36	INF	TGFB2, FGFR2, IL6, IGF2, IGF1,
24	Epithelial Adherens Junctions36	INF	MYH9, TGFB3, TGFB2, GFER, EGFR, LTBP1
25	Apoptotic Pathways in Synovial Fibroblasts36	INF	TGFB3, TGFB2, TGFB1, EGF, LTBP1, TNF
26	p38 Signaling36	INF	HSPB1, CASP3, TNF, LTBP1, IGF1, IGF2
27	MAPK Family Pathway36	INF	TGFBR2, TGFB3, TGFB2, TGFB1, GFER, HSPB1
28	eNOS Signaling36	INF	IGF2, AQP12B, FGFR2, GFER, CASP3, EGFR
29	NF-KappaB Family Pathway36	INF	LTBP1, EGF, EGFR, TGFB1, TGFB2, PSIP1
30	Amoebiasis20	INF	IL1R1, FN1, LAMA3, IL6, HSPB1, COL4A5
31	Phospholipase-C Pathway36	INF	, IGF2, LTBP1, EGF, EGFR, GFER
32	p70S6K Signaling36	INF	TGFB3, , FGF2, INS, BMP6, FGFR2
33	Cell adhesion_ECM remodeling41	INF	, LAMA3, FN1, IGF2, IGF1, SPARC
34	JAK-STAT Pathway36	INF	BMP6, IL4, IL6, TGFB2, IGF2, IGF1
35	Cell adhesion ECM remodeling10	INF	COL4A4, EGFR, COL2A1, COL4A5, , LAMA3
36	Antioxidant Action of Vitamin-C36	INF	FGFR2, EGF, LTBP1, TNF, IGF2, MAPK10
37	Nanog in Mammalian ESC Pluripotency36	INF	EGFR, GFER, TGFB1, , IL6, EPHA2
38	Ras Pathway36	INF	IGF2, EGF, FGFR2, TGFB2, GFER, PSIP1
39	Rho Family GTPases36	INF	, COL4A5, TNC, IGF1, IGF2, MAPK10
40	eIF2 Pathway36	INF	IGF1, INS, PSIP1, NUDT6, BMP6, FGFR2
41	ILK Signaling36	INF	TGFB2, FGF2, FGFR2, FBN1, MAPK10, IGF2
42	Glioma Invasiveness36	INF	GFER, , NUDT6, PSIP1, TGFB3, TGFB2
43	Actin-Based Motility by Rho Family GTPases36	INF	, TGFB3, ACTG1, IGF1, LTBP1
44	Telomerase Components in Cell Signaling36	INF	, NUDT6, PSIP1, TGFB3, GFER, EGFR
45	TGF-Beta Pathway36	INF	IL1R1, MAPK10, IL4, IL6, GFER, EGFR
46	GSK3 Signaling36	INF	TGFB3, TGFB2, PSIP1, TGFB1, GFER, EGFR
47	MAPK Signaling36	INF	COL2A1, , IL1R1, BMP6, LAMA3, FN1
48	ERK5 Signaling36	INF	NUDT6, PSIP1, TGFB3, IGF2, TGFB1, GFER
49	Molecular Mechanisms of Cancer36	INF	CYCS, TGFB3, TGFBR2, FGF2, PSIP1, PSEN2
50	Paxillin Interactions36	INF	EPHA2, , ARFGAP1, EGF, EGFR, ACTG1

Compounds related to cataract according to GeneDecks:

(show top 50)    (show all 459)

id	Compound	Score	Top Affiliating Genes
1	lipid32	INF	VIM, NAGLU, LMNA, BLZF1, SDHB, LEP
2	thymidine32 18	INF	PCNA, NAGLU, BMP6, MTHFR, , FN1
3	estrogen32	INF	PCNA, NAT2, LEP, MTHFR, CD36, CDH2
4	atp32	INF	SGCB, , LMNA, BLZF1, PARP1, SDHB
5	cisplatin32 34 9 9	INF	PCNA, NAGLU, VEGFA, BMP6, BLZF1, PARP1
6	alanine32	INF	PCNA, NAGLU, LMNA, BMP6, BLZF1, PAX6
7	tamoxifen32 34 9 9	INF	PCNA, VIM, VEGFA, BMP6, LEP, FGFR2
8	testosterone32 9 18 9	INF	SGCB, PCNA, VIM, BLZF1, SDHB, MTHFR
9	heparin32 9 18 9	INF	SERPINF1, VIM, , LCT, CD36, MMP3
10	iron32 18	INF	SGCB, VIM, NAGLU, BLZF1, SDHB, LEPREL1
11	calcium32 9 18 9	INF	SGCB, SERPINF1, NAGLU, LMNA, BLZF1, CLCN5
12	mannitol32 9 9	13.2	NAGLU, SDHB, MIP, FGF2, ALDH9A1, HSPB1
13	malondialdehyde32	10.8	NAGLU, GSR, GSS, GSTM1, GSTT1, GPT
14	citrate32	10.6	NAGLU, BLZF1, SDHB, IREB2, FH, FGF2
15	vitamin a32 9 18 9	13.5	VIM, NAGLU, NAT2, BLZF1, LEP, GSR
16	manganese superoxide32	10.2	XRCC1, GSR, GSTM1, GSTT1, IL1A, IL1RN
17	calcitriol32 42 9 18 9	14.2	BMP6, CD36, FGF2, IL13, ALB, CASR
18	4-hydroxynonenal32 18	10.8	PARP1, GSR, GSTA4, GSTM1, APOE, GPX1
19	betacarotene32	9.7	PCNA, NAT2, LEP, MTHFR, XRCC1, GSR
20	n acetylcysteine32	9.6	SGCB, PCNA, NAGLU, MMP3, GSS, FGFR2
21	cyclosporin a32 42	10.0	NAGLU, BLZF1, SDHB, LEP, MTHFR, ATP2A3
22	cysteine32	8.6	SGCB, PCNA, SERPINF1, NAGLU, NAT2, VARS
23	sb 20358032 42	9.5	VIM, VEGFA, BMP6, PARP1, CD36, MMP3
24	vitamin d32	8.2	VIM, NAGLU, BMP6, MTHFR, CD36, MMP3
25	hydrocortisone32 9 9	9.7	VIM, BMP6, LCT, CD36, INS, FGF2
26	paraffin32	INF	PCNA, VIM, VEGFA, LEP, CD36, CDH2
27	genistein32 9 18 9	INF	SGCB, PCNA, VIM, VEGFA, BLZF1, PARP1
28	polyethylene glycol32	INF	FN1, , APOE, IGF2, H6PD, G6PD
29	nitric oxide32 9 18 9	INF	SGCB, SERPINF1, NAGLU, NAT2, BMP6,
30	doxorubicin32 34 9 9	INF	VIM, BMP6, PARP1, FN1, GSR, GSTT1
31	glucose32	INF	SERPINF1, , PAX6, LCT, , ATP2A3
32	arginine32	INF	SGCB, , BLZF1, PAX6, SDHB, SCN4A
33	glutamate32	INF	PCNA, SERPINF1, VIM, BMP6, BLZF1, SDHB
34	thyroxine32 18	INF	PCNA, LEP, INS, GSR, FGF2, IL13
35	aspartate32	INF	PCNA, PCMT1, VIM, NAGLU, BMP6, SDHB
36	methotrexate32 34 42 9 9	INF	PCNA, VIM, NAGLU, NAT2, BMP6, LEP
37	tyrosine32	INF	SGCB, SERPINF1, VEGFA, BMP6, BLZF1, SDHB
38	pge232	INF	SGCB, MMP3, FN1, GSR, FGF2, IL13
39	vitamin b1232	INF	PCNA, MTHFR, , APOE, GPT, IGF1
40	tgf beta132	INF	, BMP6, BLZF1, CD36, MMP3, FN1
41	uric acid32 18	INF	NAGLU, LEP, MTHFR, INS, GSR, IL1R1
42	oxygen32 18	INF	SGCB, SERPINF1, NAGLU, BLZF1, PARP1, PAX6
43	indomethacin32 9 9	INF	PCNA, VIM, BMP6, LEP, MMP3, FN1
44	paclitaxel32 34 9 9	INF	PCNA, VIM, VEGFA, BMP6, PARP1, FN1
45	retinoic acid32 42 18	INF	GCNT2, SERPINF1, LMNA, BMP6, BLZF1, PARP1
46	cholesterol32 9 18 9	INF	, NAGLU, NAT2, LMNA, BLZF1, SDHB
47	dexamethasone32 42 34 9 9	INF	PCNA, SERPINF1, VIM, NAT2, VEGFA, BMP6
48	hyaluronic acid32 18	INF	VIM, , BMP6, CD36, MMP3, FN1
49	adenylate32	INF	SGCB, VIM, BLZF1, CDH2, GSR, FGFR2
50	alpha tocopherol32	INF	LEP, MTHFR, XRCC1, CD36, GSR, GSTM1

Cellular components related to cataract according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	INF	COL4A4, , LTF, EGF, GFER, COL2A1
2	extracellular matrix	GO:031012	INF	LTBP1, TGFB2, TGFB3, TGFBI, SOD1, SLPI
3	peroxisomal matrix	GO:005782	INF	, PRDX5, , , CAT,
4	cytosol	GO:005829	INF	PLEK, RPL21, COMT, NFE2L2, KRT14,
5	extracellular space	GO:005615	INF	, EGFR, EGF, , COL2A1, PLAT
6	lysosome	GO:005764	10.7	PRDX6, DNASE2, DNASE2B, DPP7, CTSA, CTNS
7	platelet alpha granule lumen	GO:031093	9.6	TGFB3, TGFB2, TGFB1, EGF, SPARC, ALB
8	cytoplasm	GO:005737	INF	CRYZ, PLAT, PLEK, NFE2L2, PITX2, WT1
9	cell surface	GO:009986	INF	CRYAB, PLAT, , TGFB1, TGFB2, TGFB3
10	peroxisome	GO:005777	INF	, SOD1, PRDX5, TKT, ,
11	mitochondrion	GO:005739	INF	PSEN1, TF, TGM2, GFER, , ACO1
12	endoplasmic reticulum	GO:005783	INF	TMED3, , CTSA, , , ACO1

Biological processes related to cataract according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:008284	INF	, EGF, EGFR, TGFB1, TGFB2, TGFBR2
2	visual perception	GO:007601	INF	TGFBI, OPA3, SIX6, COL2A1, , CRYZ
3	small molecule metabolic process	GO:044281	INF	, ABCB4, , G6PD, , COMT
4	eye development	GO:001654	INF	, SOX2, TGFB2, FOXC1, , PAX6
5	heart development	GO:007507	INF	TGFBR2, TGFB2, , WT1, SPARC, GJA1
6	transport	GO:006810	INF	GJB2, DYNLL1, ABCB4, , SLC25A4,
7	in utero embryonic development	GO:001701	INF	PITX2, TGFB3, TGFBR2, , MYH9, ERCC2
8	blood coagulation	GO:007596	INF	PLAT, PLEK, , EGF, ACTG1, TGFB1
9	camera-type eye development	GO:043010	INF	, WT1, PITX2, CRYBB2, CRYBA4,
10	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	PITX2, NFE2L2, OTX2, TNF, ERCC2,
11	lens development in camera-type eye	GO:002088	12.1	WNT2, LIM2, PAX6, MIP, GJA8, CRYAB
12	glutathione metabolic process	GO:006749	11.3	GGT1, SOD1, G6PD, CTNS, GPX3, GPX1
13	lens fiber cell development	GO:070307	11.0	FGFR2, BFSP2, BFSP1, VIM
14	aging	GO:007568	10.9	WRN, TGFB3, TGFB2, TGFB1, CRYAB, NR3C1
15	ATP biosynthetic process	GO:006754	10.9	TGFB1, ATP7B, ATP2A2, ATP2A1, ATP7A, ATP2A3
16	positive regulation of protein secretion	GO:050714	10.9	ADAM9, TGFB3, TGFB2, TGFB1, IL13, BMP6
17	inner ear morphogenesis	GO:042472	10.8	SIX4, SOX2, TFAP2A, COL2A1, OTX2, MAFB
18	salivary gland morphogenesis	GO:007435	10.7	TGFB3, TGFB2, TGFB1, EGFR, PAX6
19	hydrogen peroxide catabolic process	GO:042744	10.7	GPX1, GPX3, CAT, PRDX6, PRDX5
20	lens fiber cell differentiation	GO:070306	10.7	TDRD7, TGFB1, CRYGD, MAF
21	positive regulation of catalytic activity	GO:043085	10.6	SOD1, PSEN2, PSEN1, CTSA, IGF2, ATP7A
22	response to wounding	GO:009611	10.5	SOX2, TGFB2, TGFB1, TNC, CASP3, FN1
23	lung alveolus development	GO:048286	10.5	SOX2, PSEN2, TGFB3, IGF1, FGFR2, ATP7A
24	positive regulation of insulin receptor signaling pathway	GO:046628	10.4	SIRT1, IGF2, INS, LEP
25	female pregnancy	GO:007565	10.3	HFE, TGFB1, TGFB2, TGFB3, COMT, IDO1
26	positive regulation of DNA binding	GO:043388	10.0	EGF, PITX2, TXN, ERCC2, IGF1
27	positive regulation of MAPK cascade	GO:043410	9.7	IGF2, IGF1, DUSP19, SOX2, IL6, FGFR2
28	anti-apoptosis	GO:006916	9.5	POLB, SOD1, PSEN1, CRYAB, CRYAA, NR3C1
29	angiogenesis	GO:001525	9.4	MYH9, EPHA2, SIRT1, TGFBI, TGFB2, EGF
30	response to glucocorticoid stimulus	GO:051384	9.4	SPARC, PLAT, ABCB4, ADAM9, PTGS2, TNF
31	positive regulation of mitosis	GO:045840	9.3	EGF, TNF, IGF1, IGF2, IL1A, INS
32	negative regulation of cell proliferation	GO:008285	9.1	WT1, TGFB1, TGFB2, TGFB3, TFAP2A, SOD2
33	response to drug	GO:042493	INF	PTGS2, COMT, ABCB4, TGFB1, TGFB2, TGFBR2
34	positive regulation of cell division	GO:051781	INF	TGFB3, TGFB2, TGFB1, , CAT, IGF2
35	inner ear development	GO:048839	INF	SOX2, TGFB3, TGFB2, TGFB1, , SPARC
36	platelet activation	GO:030168	INF	EGF, TGFB1, TGFB2, TGFB3, TF, SOD1
37	lung lobe morphogenesis	GO:060463	INF	TGFBR2, , IGF1, FGFR2
38	male genitalia development	GO:030539	INF	SOX2, , WT1, GJB2, BMP6
39	base-excision repair	GO:006284	INF	WRN, POLB, , XRCC1, PARP1, PCNA
40	blood vessel endothelial cell migration	GO:043534	INF	MYH9, HSPB1, GPX1,
41	response to oxidative stress	GO:006979	INF	PRDX6, PRDX5, , SIRT1, WRN, PSEN1
42	cellular membrane organization	GO:016044	INF	DNM2, GJB2, GJA1, , ARFGAP1, FTL
43	positive regulation of transcription, DNA-dependent	GO:045893	INF	WT1, , EGF, TGFB1, TGFB3, TFAP2A
44	response to organic nitrogen	GO:010243	INF	TGFB2, , PTGS2, IL1RN, IL1A, MGST1
45	platelet degranulation	GO:002576	INF	EGF, TGFB1, TGFB2, TGFB3, TF, SOD1
46	induction of apoptosis	GO:006917	INF	TGM2, TGFB3, TGFB2, TGFB1, HIP1, WT1
47	response to hypoxia	GO:001666	INF	CRYAA, CRYAB, PLAT, , TGFB1, TGFB2
48	kidney development	GO:001822	INF	, TFAP2A, TGFB2, ACE, WT1, ALDH9A1
49	negative regulation of apoptotic process	GO:043066	INF	EGFR, , WT1, COL2A1, CRYAA, TGFB2

Molecular functions related to cataract according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	GGT1, GAPDH, EPHA2, HADHA, ADAM9, WRN
2	cytokine activity	GO:005125	INF	TGFB2, SLURP1, WNT2, , , TNF
3	growth factor activity	GO:008083	INF	GFER, TGFB1, TGFB2, TGFB3, NUDT6,
4	protein homodimerization activity	GO:042803	INF	MAF, VEGFA, XPNPEP1, APOE, FGFR2, GSTM3
5	structural constituent of eye lens	GO:005212	12.1	CRYGS, MIP, BFSP2, BFSP1, LIM2, VIM
6	structural constituent of cytoskeleton	GO:005200	10.8	DES, HIP1, ACTG1, KRT14, DMD, TUBB
7	glutathione peroxidase activity	GO:004602	10.7	PRDX6, GPX3, GPX1, GSTT1, MGST1
8	NADP binding	GO:050661	10.7	GSR, CAT, CRYM, H6PD, G6PD, GAPDH
9	glutathione binding	GO:043295	10.6	GPX3, GSS, GSR, MGST1
10	antioxidant activity	GO:016209	10.3	APOE, ALB, CAT, PRDX6, PRDX5
11	identical protein binding	GO:042802	INF	CRYBB2, COL2A1, EGFR, ACTG1, TGFB3,