MCID: CTR002
MIFTS: 58

Cataract malady

Categories: Eye diseases, Rare diseases, Genetic diseases, Fetal diseases, Neuronal diseases

Aliases & Classifications for Cataract

Aliases & Descriptions for Cataract:

Name: Cataract 38 12 29 29 52 41 42 14

Classifications:



External Ids:

Disease Ontology 12 DOID:83
ICD10 33 H26
ICD9CM 35 366.8
MeSH 42 D002386
SNOMED-CT 64 193620000 193622008
UMLS 69 C0029531

Summaries for Cataract

MedlinePlus : 41 a cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all americans either have a cataract or have had cataract surgery. a cataract can occur in either or both eyes. it cannot spread from one eye to the other. common symptoms are blurry vision colors that seem faded glare - headlights, lamps or sunlight may seem too bright. you may also see a halo around lights. not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute

MalaCards based summary : Cataract is related to hyperferritinemia-cataract syndrome and cataract 21, multiple types. An important gene associated with Cataract is CRYAA (Crystallin Alpha A). The drugs Gabapentin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include Eye, eye and endothelial, and related phenotype is vision/eye.

Disease Ontology : 12 A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.

Wikipedia : 71 A cataract is a clouding of the lens in the eye which leads to a decrease in vision. Cataracts often... more...

Related Diseases for Cataract

Diseases in the Cataract family:

Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 39, Multiple Types, Autosomal Dominant Cataract 2, Multiple Types
Cataract 4, Multiple Types Cataract 42
Cataract 18, Autosomal Recessive Cataract 20, Multiple Types
Cataract 41 Cataract 38, Autosomal Recessive
Cataract 26, Multiple Types Cataract 36
Cataract 11, Multiple Types Cataract 16, Multiple Types
Cataract 15, Multiple Types Cataract 14, Multiple Types
Cataract 32, Multiple Types Cataract 25
Cataract 5, Multiple Types Cataract 21, Multiple Types
Cataract 43 Cataract 10, Multiple Types
Cataract 7 Cataract 19
Cataract 33 Cataract 31, Multiple Types
Cataract 9, Multiple Types Cataract 44
Cataract 17, Multiple Types Cataract 3, Multiple Types
Cataract 22, Autosomal Recessive Cataract 23
Cataract 46 Juvenile-Onset Cataract 28
Cataract 37 Cataract 35
Cataract 45 Cataract 19 Multiple Types
Cataract Congenital Autosomal Dominant Cataract, Total Congenital
Cataract 47 Cataract, Autosomal Dominant Congenital 4
Cataracts, Autosomal Recessive Foxe3-Related Cataracts, Autosomal Dominant

Diseases related to Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 707)
id Related Disease Score Top Affiliating Genes
1 hyperferritinemia-cataract syndrome 12.3
2 cataract 21, multiple types 12.2
3 cataract 9, multiple types 12.2
4 cataract 1, multiple types 12.2
5 cataract 4, multiple types 12.1
6 cataract 3, multiple types 12.1
7 cataract 6, multiple types 12.1
8 cataract 2, multiple types 12.1
9 cataract 11, multiple types 12.1
10 cataract 17, multiple types 12.1
11 cataract 16, multiple types 12.1
12 cerulean cataract 12.1
13 cataract 22, autosomal recessive 12.1
14 cataract 10, multiple types 12.1
15 cataract 23 12.1
16 cataract 30, pulverulent 12.1
17 cataract 31, multiple types 12.1
18 cataract 18, autosomal recessive 12.1
19 cataract 14, multiple types 12.1
20 cataract 5, multiple types 12.1
21 congenital cataracts, facial dysmorphism, and neuropathy 12.1
22 cataract 40, x-linked 12.0
23 cataract 41 12.0
24 cataract 39, multiple types, autosomal dominant 12.0
25 cataract 24, anterior polar 12.0
26 cataract 33 12.0
27 cataract 7 12.0
28 cataract 8, multiple types 12.0
29 cataract 34, multiple types 12.0
30 cataract 38, autosomal recessive 12.0
31 cataract 46 juvenile-onset 12.0
32 cataract 26, multiple types 12.0
33 cataract 32, multiple types 12.0
34 cataract 20, multiple types 12.0
35 cataract 13 with adult i phenotype 12.0
36 cataract 25 12.0
37 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 12.0
38 cataract 15, multiple types 12.0
39 cataract 29, coralliform 12.0
40 cataract 44 12.0
41 cataract 43 11.9
42 cataract, juvenile, with microcornea and glucosuria 11.9
43 3-methylglutaconic aciduria, type vii, with cataracts, neurologic involvement and neutropenia 11.9
44 congenital cataracts, hearing loss, and neurodegeneration 11.9
45 cataract 42 11.9
46 cataract 27, nuclear progressive 11.9
47 cataract 37 11.9
48 cataract 35 11.9
49 myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay 11.9
50 hydrocephalus, endocardial fibroelastosis, and cataracts 11.9

Graphical network of the top 20 diseases related to Cataract:



Diseases related to Cataract

Symptoms & Phenotypes for Cataract

MGI Mouse Phenotypes related to Cataract:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.5 BFSP1 BFSP2 CRYAB CRYBA1 CRYGC CRYGD

Drugs & Therapeutics for Cataract

Drugs for Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 394)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4,Phase 1,Phase 2 60142-96-3 3446
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
3
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved Phase 4,Phase 3,Phase 2,Phase 1 35189-28-7 6540478
6
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
7
Loteprednol Approved Phase 4,Phase 3 82034-46-6, 129260-79-3 444025 9865442
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
10
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
11
Nepafenac Approved Phase 4,Phase 3,Phase 2 78281-72-8 151075
12
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1 9004-61-9 53477741 24759
13
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
15
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2 32986-56-4 5496 36294
16
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
17
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
18
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
19
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
20
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
21
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
22
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
23
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
24
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 216974-75-3
25
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
26
Dalteparin Approved Phase 4 9041-08-1
27
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
29
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
30
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
31
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
32
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
33
Dinoprostone Approved Phase 4 363-24-6 5280360
34
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
35
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
36
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
37
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
38
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
39
Gatifloxacin Approved, Investigational Phase 4,Phase 1 112811-59-3 5379
40
Vancomycin Approved Phase 4 1404-90-6 441141 14969
41
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
42
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
43
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Phase 2 85721-33-1 2764
44
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
45
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
46
Ethanol Approved Phase 4 64-17-5 702
47
Budesonide Approved Phase 4 51333-22-3 63006 5281004
48
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 67-73-2 6215
49
Travoprost Approved Phase 4,Phase 2 157283-68-6 5282226
50
Azathioprine Approved Phase 4 446-86-6 2265

Interventional clinical trials:

(show top 50) (show all 983)
id Name Status NCT ID Phase
1 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
2 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
3 A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. Unknown status NCT00326066 Phase 4
4 Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Unknown status NCT01455467 Phase 4
5 Effect of Gabapentin on Pain of the Second Cataract Surgery Unknown status NCT02127853 Phase 4
6 A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery Unknown status NCT01296542 Phase 4
7 Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens Unknown status NCT01615861 Phase 4
8 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
9 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4
10 Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification Unknown status NCT01193504 Phase 4
11 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
12 Efficacy of Subtenon's Block With Olive Tipped Cannula Unknown status NCT01019018 Phase 4
13 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
14 Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies Unknown status NCT00865540 Phase 4
15 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
16 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
17 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4
18 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
19 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4
20 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
21 IntraVitreal Triamcinolone Acetonide: Preventing Raised Eye-pressure by Tracking Elevations After Topical Steroids Unknown status NCT00744666 Phase 4
22 Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema Unknown status NCT02399657 Phase 4
23 Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery Completed NCT02023437 Phase 4
24 Aphakia Versus Pseudophakia in Children Under 2 Years Undergoing Bilateral Congenital Cataract Surgery Completed NCT01297153 Phase 4
25 A Single Centre Study to Analyze Cataract Surgery Following Femtosecond Laser-Assisted and Manual Cataract Surgery Completed NCT01769313 Phase 4
26 Size Progression of Macular Degeneration After Cataract Surgery Completed NCT01165801 Phase 4
27 To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery. Completed NCT00763360 Phase 4
28 Clinical Trial on Anti-inflammatory Effect of Low-Molecular Weight Heparin in Pediatric Cataract Surgery Completed NCT00986076 Phase 4
29 Dexmedetomidine vs. Propofol for Cataract Surgery Completed NCT00786370 Phase 4
30 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
31 Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism Completed NCT01763151 Phase 4
32 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed NCT00870103 Phase 4
33 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed NCT01261975 Phase 4
34 2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery Completed NCT01455233 Phase 4
35 Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery Completed NCT00575380 Phase 4
36 Comparing Optical Coherence Tomography (OCT) and Visual Acuity Outcomes in Subjects Undergoing Cataract Surgery, Who Receive Xibrom Ophthalmic Solution and Standard Presurgical Care vs. Xibrom Ophthalmic Solution Plus Prednisolone Acetate 1% and Standard Completed NCT00698724 Phase 4
37 Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema Completed NCT01546402 Phase 4
38 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4
39 Laser Cataract Surgery With the Femtosecond Laser Technology Completed NCT01382823 Phase 4
40 Dispervise Ophthalmic Viscoelastic as an Agent to Ensure Watertight Wound Closure After Clear Corneal Cataract Incisions Completed NCT01298973 Phase 4
41 Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery Completed NCT01542190 Phase 4
42 Determination of Optimum Duration of Treatment With Bromfenac (Xibrom) Eyedrops Following Cataract Surgery Completed NCT00758199 Phase 4
43 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
44 Influence of Two Different Preloaded Intraocular Lens (IOLs) on Posterior Capsule Opacification Completed NCT00673803 Phase 4
45 Clear Corneal Incisions and Arcuate Incisions Utilizing FemtoSecond Laser Technology for Cataract Surgery Completed NCT01383057 Phase 4
46 Acular LS vs. Nevanac in Post op Inflammation Following Cataract Surgery Completed NCT00348582 Phase 4
47 Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs Completed NCT00366587 Phase 4
48 Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients Completed NCT01859702 Phase 4
49 Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects Completed NCT00469690 Phase 4
50 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed NCT02150460 Phase 4

Search NIH Clinical Center for Cataract

Cochrane evidence based reviews: cataract

Genetic Tests for Cataract

Genetic tests related to Cataract:

id Genetic test Affiliating Genes
1 Cataract 29

Anatomical Context for Cataract

MalaCards organs/tissues related to Cataract:

39
Eye, Endothelial, Brain, Testes, Skin, Heart, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Cataract:
id Tissue Anatomical CompartmentCell Relevance
1 Eye Lens Affected by disease

Publications for Cataract

Articles related to Cataract:

(show top 50) (show all 2857)
id Title Authors Year
1
Down-regulation of GJA3 is associated with lens epithelial cell apoptosis and age-related cataract. ( 28088522 )
2017
2
A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. ( 28132692 )
2017
3
Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression. ( 28065730 )
2017
4
Re: Javitt JC: Intracameral antibiotics reduce the risk of endophthalmitis after cataract surgery: does the preponderance of the evidence mandate a global change in practice? (Ophthalmology 2016;123:226-231). ( 27993282 )
2017
5
Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level. ( 28071717 )
2017
6
Re: Javitt JC: Intracameral antibiotics reduce the risk of endophthalmitis after cataract surgery: does the preponderance of the evidence mandate a global change in practice? (Ophthalmology 2016;123:226-231). ( 27993280 )
2017
7
Comparative study of 25- versus 20-gauge pars plana capsulotomy and vitrectomy in pediatric cataract surgery. ( 28063099 )
2017
8
A novel frameshift mutation in the sterol 27-hydroxylase gene in an Egyptian family with cerebrotendinous xanthomatosis without cataract. ( 28229379 )
2017
9
Cataract surgery in uveitis: a multicentre database study. ( 28043984 )
2017
10
Whole Exome Sequencing Identifies a Novel Mutation in the PITX3 Gene, Causing Autosomal Dominant Congenital Cataracts in a Chinese Family. ( 28249924 )
2017
11
Sulforaphane promotes ER stress, autophagy, and cell death: implications for cataract surgery. ( 28083623 )
2017
12
Risk Factors for Posterior Subcapsular Cataract in Retinitis Pigmentosa. ( 28492871 )
2017
13
Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis. ( 27840165 )
2017
14
Rates of Routine Cataract Surgery Among Medicare Beneficiaries. ( 28056119 )
2017
15
Optic atrophy, cataracts, lipodystrophy/lipoatrophy, and peripheral neuropathy caused by a de novo OPA3 mutation. ( 28050599 )
2017
16
Change of Capsulotomy Over 1 Year in Femtosecond Laser-Assisted Cataract Surgery and Its Impact on Visual Quality. ( 28068446 )
2017
17
Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment. ( 28190456 )
2017
18
Re: Jabbarvand etA al.: Endophthalmitis occurring after cataract surgery: outcomes of more than 480 000 cataract surgeries, epidemiologic features, and risk factors (Ophthalmology 2016;123:295-301). ( 27993276 )
2017
19
Preoperative Expectations and Postoperative Outcomes of Visual Functioning among Cataract Patients in Urban Southern China. ( 28068402 )
2017
20
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( 27520089 )
2016
21
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. ( 27078007 )
2016
22
Congenital Cataracts, Facial Dysmorphism, and Neuropathy Syndrome: Additional Clinical Features. ( 28041656 )
2016
23
Postoperative hemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin prophylaxis duringA cataract surgery. ( 27956296 )
2016
24
The impact of preoperative evaluation on perioperative events in patients undergoing cataract surgery: a cohort study. ( 27636228 )
2016
25
Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma: methodological issues of prediction model. ( 27526198 )
2016
26
A Novel Capsulorhexis Technique in White Cataract Surgery. ( 27191865 )
2016
27
Prenatal observation of nystagmus, cataracts, and brain abnormalities in a case of Zellweger spectrum disorder syndrome. ( 27392320 )
2016
28
Effect of antibiotic prophylaxis on Coagulase-negative Staphylococcus virulence factor profiles in patients undergoing cataract surgery. ( 27655297 )
2016
29
Effect of the Femtosecond Laser on an Intracorneal Inlay for Surgical Compensation of Presbyopia during Cataract Surgery: Scanning Electron Microscope Imaging. ( 27260475 )
2016
30
Congenital Cataract Screening. ( 27621790 )
2016
31
Determination of Serum Ceruloplasmin Concentration in Patients with Primary Open Angle Glaucoma with Cataract and Patients with Cataract Only: A Pilot Study. ( 27109647 )
2016
32
Cataract in pseudohypoparathyroidism. ( 27492110 )
2016
33
Toric intraocular lens implantation in children with developmental cataract and preexisting corneal astigmatism. ( 27573881 )
2016
34
A Novel CRYBB2 Stopgain Mutation Causing Congenital Autosomal Dominant Cataract in a Chinese Family. ( 28025620 )
2016
35
The Auckland Cataract Study: assessing preoperative risk stratification systems for phacoemulsification surgery in a teaching hospital. ( 27637785 )
2016
36
Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts. ( 27294265 )
2016
37
Glaukos iStent injectAr Trabecular Micro-Bypass Implantation Associated with Cataract Surgery in Patients with Coexisting Cataract and Open-Angle Glaucoma or Ocular Hypertension: A Long-Term Study. ( 27882243 )
2016
38
Combined Special Capsular Tension Ring and Toric IOL Implantation for Management of Astigmatism and High Axial Myopia with Cataracts. ( 28005433 )
2016
39
Refractive Outcome of Cataract Surgery in Eyes With Prior Trabeculectomy: Risk Factors for Postoperative Myopia. ( 27661991 )
2016
40
Hutterite-type cataract maps to chromosome 6p21.32-p21.31, cosegregates with a homozygous mutation in LEMD2, and is associated with sudden cardiac death. ( 26788539 )
2016
41
Retinal vasculitis associated with autoantibodies of primary SjAPgren's syndrome after cataract surgery. ( 26875858 )
2016
42
Cataract surgery in dementia patients-time to reconsider anaesthetic options. ( 28077527 )
2016
43
Favorable Long-term Prognosis of Cataract Surgery in Herpes Zoster Ophthalmicus. ( 27413505 )
2016
44
A novel MIP mutation in familial congenital nuclear cataracts. ( 27456987 )
2016
45
Human aqueous humor proteome in cataract, glaucoma and pseudoexfoliation syndrome. ( 27193151 )
2016
46
Operating Room Performance Improves after Proficiency-Based Virtual Reality Cataract Surgery Training. ( 28017423 )
2016
47
Stratifying the risk factors for endophthalmitis after cataract surgery. ( 27063544 )
2016
48
Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity. ( 27372406 )
2016
49
Q192R paraoxonase1 polymorphism is a risk factor for cataract in Pakistani population. ( 27166546 )
2016
50
Endophthalmitis prophylaxis in cataract surgery: Overview of current practice patterns around the world. ( 27981903 )
2016

Variations for Cataract

ClinVar genetic disease variations for Cataract:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Cataract from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 86882 14 67000000 106368585 Copy number cataract
2 89231 15 17000000 100338915 Copy number cataract
3 106728 17 1 11200000 Copy number cataract

Expression for Cataract

Search GEO for disease gene expression data for Cataract.

Pathways for Cataract

GO Terms for Cataract

Cellular components related to Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 connexin complex GO:0005922 8.96 GJA3 GJA8
2 gap junction GO:0005921 8.8 GJA3 GJA8 MIP

Biological processes related to Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.73 BFSP2 CRYAA CRYBA1 CRYBA4 CRYBB1 CRYBB3
2 protein homooligomerization GO:0051260 9.67 CRYAA CRYAB GJA8 HSF4
3 camera-type eye development GO:0043010 9.56 CRYBA4 GJA8 HSF4 LIM2
4 negative regulation of cytokine production GO:0001818 9.43 CRYBA1 EPHA2
5 lens fiber cell development GO:0070307 9.4 BFSP1 BFSP2
6 lens fiber cell differentiation GO:0070306 9.33 CRYGD MAF PITX3
7 negative regulation of intracellular transport GO:0032387 9.32 CRYAA CRYAB
8 lens development in camera-type eye GO:0002088 9.28 CRYAB CRYBA1 CRYGD CRYGS GJA8 LIM2

Molecular functions related to Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.44 BFSP1 BFSP2 CRYAA CRYAB CRYBA1 CRYBA4
2 gap junction channel activity GO:0005243 8.96 GJA3 GJA8

Sources for Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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