MCID: CTR002
MIFTS: 48

Cataract malady

Summaries for Cataract

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 A cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all americans either have a cataract or have had cataract surgery. a cataract can occur in either or both eyes. it cannot spread from one eye to the other. common symptoms are blurry vision colors that seem faded glare - headlights, lamps or sunlight may seem too bright. you may also see a halo around lights. not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute

MalaCards: Cataract is related to cataract, congenital and posterior polar cataract. An important gene associated with Cataract is NHS (Nance-Horan syndrome (congenital cataracts and dental anomalies)), and among its related pathways is Membrane Trafficking. The compounds cp-49 and mp 26 have been mentioned in the context of this disorder. Related mouse phenotype vision/eye.

Wikipedia:64 A cataract is a clouding of the lens inside the eye which leads to a decrease in vision. It is the most... more...

Aliases & Classifications for Cataract

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 27ICD9CM, 35MeSH, 61UMLS, 57SNOMED-CT
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Aliases & Descriptions:

cataract 8 45 34


External Ids:

Disease Ontology8 DOID:83
ICD9CM27 366.8
MeSH35 D002386

Related Diseases for Cataract

Sources:
17GeneCards, 18GeneDecks
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Diseases in the cataract 1, multiple types family:

cataract cataract, congenital, with microcornea or slight microphthalmia
cataract, total congenital cataract 8, multiple types
cataract 6, multiple types cataract 34, multiple types
cataract 2, multiple types cataract 4, multiple types
cataract 12, multiple types cataract 20, multiple types
cataract 13 with adult i phenotype cataract 26, multiple types
cataract 36 cataract, juvenile, with microcornea and glucosuria
cataract 11, multiple types cataract with late-onset corneal dystrophy
cataract 16, multiple types cataract 15, multiple types
cataract 14, multiple types cataract 32, multiple types
cataract, congenital cataract 25
cataract 5, multiple types cataract 10, multiple types
cataract 7 cataract 19
cataract 33 cataract 31, multiple types
cataract 9, multiple types cataract 17, multiple types
cataract 3, multiple types cataract 23

Diseases related to Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 753)
idRelated DiseaseScoreTop Affiliating Genes
1cataract, congenital31.4GALK1, BFSP2, PITX3, CRYBA1, CRYBB2, CRYBB3
2posterior polar cataract30.8CRYBA1, PITX3, BFSP1
3cataracts, autosomal dominant30.6CRYBB2, CRYAA, GJA8
4microphthalmia30.5SIX6, PITX3, CRYAA, GJA8
5blindness30.4CRYAA, CRYGC
6cataract 4, multiple types30.3FTL, GJA8, CRYGD, CRYAA, BFSP1
7cataract 3, multiple types30.1CRYGC, CRYBB2
8diabetic cataract10.8
9cataract-glaucoma10.7
10hyperferritinemia cataract syndrome10.6
11astigmatism10.6
12cataract congenital autosomal dominant10.6
13cystoid macular edema10.4
14microphthalmia cataract10.4
15aniridia10.4
16mature cataract10.4
17uveitis10.4
18n syndrome10.4
19micro syndrome10.4
20cataract, zonular10.4
21cerulean cataract10.4
22mental retardation10.4
23exfoliation syndrome10.3
24acute endophthalmitis10.3
25coloboma10.3
26hypomyelination and congenital cataract10.3
27immature cataract10.3
28cataract microcornea syndrome10.3
29congenital cataracts, facial dysmorphism, and neuropathy10.3
30nance-horan syndrome10.3
31cerebrotendinous xanthomatosis10.3
32ataxia10.3
33morgagni cataract10.2
34microcephaly10.2
35diabetic macular edema10.2
36retinitis pigmentosa10.2
37phacolytic glaucoma10.2
38trichomegaly, cataract, and hereditary spherocytosis10.2
39myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay10.2
40persistent hyperplastic primary vitreous10.2
41cataract 1, multiple types10.2
42cataract 1910.2
43myotonic cataract10.2
44galactokinase deficiency10.2
45presbyopia10.2
46xanthomatosis10.2
47cataract ataxia deafness10.2
48cardiomyopathy cataract hip spine disease10.2
49cataract congenital volkmann type10.2
50cataracts, autosomal recessive10.2

Graphical network of the top 20 diseases related to Cataract:



Diseases related to cataract

Clinical Features for Cataract

Drugs & Therapeutics for Cataract

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cataract

Drug clinical trials:

Search ClinicalTrials for Cataract

Search NIH Clinical Center for Cataract

Search CenterWatch for Cataract

Genetic Tests for Cataract

Anatomical Context for Cataract

Animal Models for Cataract or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cataract:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539112.3TDRD7, BFSP2, BFSP1, GALK1, PITX3, CRYBA1

Publications for Cataract

Sources:
51PubMed
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Articles related to Cataract:

(show top 50)    (show all 2402)
idTitleAuthorsYear
1
Nutritional modulation of cataract. (24279748)
2014
2
Surgical simulators in cataract surgery training. (24158838)
2014
3
Epithelial wound healing after cataract surgery comparing two different topical fluoroquinolones. (24339307)
2014
4
Simultaneous penetrating keratoplasty and cataract surgery. (23825711)
2013
5
Changes in choroidal thickness after cataract surgery. (24360848)
2013
6
Effect of heparin coating of a foldable intraocular lens on inflammation and capsular bag performance after cataract surgery. (24140372)
2013
7
Interleukin-6 in the pathogenesis of posterior capsule opacification and the potential role for interleukin-6 inhibition in the future of cataract surgery. (23375410)
2013
8
ENDOPHTHALMITIS CAUSED BY ACHROMOBACTER XYLOSOXIDANS AFTER CATARACT SURGERY. (24150240)
2013
9
Homozygous mutation of the 5'UTR region of the L-Ferritin gene in the hereditary hyperferritinemia cataract syndrome and its impact on the phenotype. (23300176)
2013
10
Chaperone peptides of I+-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. (23508955)
2013
11
Cataract extraction surgery in patients with uveitis in Taiwan: Risk factors and outcomes. (24296307)
2013
12
Intraocular lens implantation procedures in aphakic eyes with insufficient capsular support associated with previous cataract surgery. (23898947)
2013
13
Randomized trial of multifocal intraocular lenses versus monovision after bilateral cataract surgery. (24070808)
2013
14
Role of patient choice in influencing wait time for cataract surgery. (23931460)
2013
15
Cataract surgery in patients with corneal disease. (23197265)
2013
16
Approaches to corneal astigmatism in cataract surgery. (23197264)
2013
17
New side-view imaging technique for observing posterior chamber structures during cataract surgery in porcine eyes. (24053470)
2013
18
Congenital ocular malformations (lens subluxation, pupillary displacement, cataract, myopia) and classic galactosaemia associated with Q188R anda88/or G1391A mutations. (20222886)
2011
19
The complications during phacoemulsification in patients with posterior polar cataract. (21853943)
2011
20
Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. (21228318)
2011
21
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. (21573094)
2011
22
Risk factors for poor visual outcome following cataract surgery in Vogt-Koyanagi-Harada disease. (21349937)
2011
23
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
24
Bilateral uneven cataracts in children: amblyopia management by sequential intraocular lens implantation. (19247388)
2009
25
A novel nonsense mutation in CRYGC is associated with autosomal dominant congenital nuclear cataracts and microcornea. (19204787)
2009
26
Incidence of posterior vitreous detachment after cataract surgery. (19465281)
2009
27
Phacoemulsification versus small incision cataract surgery (SICS): which one is a better surgical option for immature cataract in developing countries? (21141000)
2009
28
Bannayan-Riley-Ruvalcaba syndrome with posterior subcapsular congenital cataract and a consensus sequence splicing PTEN mutation. (18080326)
2008
29
Novel MAF mutation in a family with congenital cataract-microcornea syndrome. (17982426)
2007
30
CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q. (17701905)
2007
31
Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin. (15709761)
2005
32
A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2 gene (GCNT2): association with autosomal recessive congenital cataracts. (15161861)
2004
33
Mutation spectrum in Australian pedigrees with hereditary hyperferritinaemia-cataract syndrome reveals novel and de novo mutations. (12199804)
2002
34
Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. (12458487)
2002
35
Decreased expression of ribosomal proteins in human age-related cataract. (11773032)
2002
36
Idiopathic hypoparathyroidism and celiac disease in two patients with previous history of cataract. (10659486)
2000
37
A new mutation (G51C) in the iron-responsive element (IRE) of L-ferritin associated with hyperferritinaemia-cataract syndrome decreases the binding affinity of the mutated IRE for iron-regulatory proteins. (10759702)
2000
38
Progressive juvenile-onset punctate cataracts caused by mutation of the gamma-D-crystallin gene. (9927684)
1999
39
Hereditary hyperferritinemia-cataract syndrome: two novel mutations in the L-ferritin iron-responsive element. (9414313)
1998
40
Evidence for the participation of alpha B-crystallin in human age-related nuclear cataract. (9650087)
1998
41
Chronic endophthalmitis after extracapsular cataract extraction caused by Mycobacterium chelonae subspecies abscessus. (8849553)
1995
42
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
43
Phacolytic glaucoma--its treatment by planned extracapsular cataract extraction with posterior chamber intraocular lens implantation. (7829178)
1994
44
Metabolic studies of galactosemic cataract. (2209747)
1990
45
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. (3917257)
1985
46
Human senile cataract and Na-K ATP'ase activity in the anterior lens structures with special reference to anterior capsular/subcapsular opacity. (6259880)
1980
47
Ultrastructural study of cataract in myotonia dystrophica. (930995)
1977
48
Hyperglycinuria in a family with autosomal dominantly inherited cataract. (4430153)
1974
49
The ocular syndrome of cataract and papilledema in the manifest form of parathyroid deficiency. (18861159)
1948
50
Vitamin C saturation and senile cataract. (21004334)
1945

Genetic Variations for Cataract

Expression for genes affiliated with Cataract

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cataract

Search GEO for disease gene expression data for Cataract.

Pathways for genes affiliated with Cataract

Sources:
54Reactome
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Pathways related to Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9GJA8, GJA3, FTL, CHMP4B

Compounds for genes affiliated with Cataract

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Cataract according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cp-494510.9BFSP1, BFSP2
2mp 264510.8GJA3, CRYAA
3gap 276010.8GJA3, GJA8
4carbenoxolone disodium6010.8GJA3, GJA8
5scrambled 10panx6010.7GJA3, GJA8
6carbenoxolone29 45 1112.7GJA8, GJA3
710panx6010.6GJA3, GJA8
8octanol29 2411.4GJA8, GJA3

GO Terms for genes affiliated with Cataract

Sources:
16Gene Ontology
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Cellular components related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.5BFSP1, GALK1, CRYBA1, CRYAA, CRYGC, CRYGD
2connexon complexGO:00592210.4GJA8, GJA3

Biological processes related to Cataract according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.7SIX6, BFSP2, CRYBA1, CRYBB2, CRYBB3, CRYAA
2lens development in camera-type eyeGO:00208811.2PITX3, CRYBA1, CRYGD, CRYGS, GJA8, NHS
3lens fiber cell differentiationGO:07030611.0TDRD7, MAF, CRYGD, PITX3
4camera-type eye developmentGO:04301010.8HSF4, CRYBB2, CRYGC
5lens morphogenesis in camera-type eyeGO:00208910.7TDRD7, PITX3
6lens fiber cell developmentGO:07030710.6BFSP1, BFSP2
7cell developmentGO:04846810.4MAF, HSF4

Molecular functions related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of eye lensGO:00521211.4CRYGS, CRYGD, CRYGC, CRYAA, CRYBB3, CRYBB2

Products for genes affiliated with Cataract

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  • Lysates
  • Antibodies

Sources for Cataract

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet