MCID: CTR002
MIFTS: 60

Cataract

Categories: Eye diseases, Rare diseases, Genetic diseases, Fetal diseases, Metabolic diseases, Nephrological diseases, Neuronal diseases, Oral diseases

Aliases & Classifications for Cataract

Summaries for Cataract

PubMed Health : 59
About cataracts: A cataract is an eye condition in which the lens of the eye becomes cloudy. This causes vision to worsen, making it especially difficult to see fine details clearly. Some people’s vision is only slightly affected, whereas others might lose their eyesight very quickly. How it progresses will depend on things like the exact type of cataract. The word “cataract” comes from the Greek word for “waterfall” because in the past it was believed that the blurring was caused by a fluid in the eye.Cataracts mostly affect people over 50, and the risk increases with age: About 20 out of 100 people between the ages of 65 and 74 have a cataract. And more than 50 out of 100 people over the age of 74 are affected.Cataracts are the main cause of blindness in developing countries. The number of people who go blind from cataracts is considerably lower in industrialized countries due to the availability of effective surgery. Cataract surgery involves removing the cloudy eye lens and replacing it with an artificial lens. It is one of the most common surgical procedures performed in Germany, where about 800,000 people have cataract surgery every year.

MalaCards based summary : Cataract, also known as cataracts, is related to cataract 16, multiple types and cataract 9, multiple types. An important gene associated with Cataract is IARS2 (Isoleucyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways is Protein processing in endoplasmic reticulum. The drugs Gabapentin and gamma-Aminobutyric acid have been mentioned in the context of this disorder. Affiliated tissues include Eye, eye and endothelial, and related phenotype is vision/eye.

Disease Ontology : 12 A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.

MedlinePlus : 40 A cataract is a clouding of the lens in your eye. It affects your vision. Cataracts are very common in older people. By age 80, more than half of all Americans either have a cataract or have had cataract surgery. A cataract can occur in either or both eyes. It cannot spread from one eye to the other. Common symptoms are Blurry vision Colors that seem faded Glare - headlights, lamps or sunlight may seem too bright. You may also see a halo around lights. Not being able to see well at night Double vision Frequent prescription changes in your eye wear Cataracts usually develop slowly. New glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. Surgery is also an option. It involves removing the cloudy lens and replacing it with an artificial lens. Wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. NIH: National Eye Institute

Wikipedia : 72 A cataract is a clouding of the lens in the eye which leads to a decrease in vision. Cataracts often... more...

Related Diseases for Cataract

Diseases in the Cataract family:

Cataract 32, Multiple Types Cataract 7
Cataract 8, Multiple Types Cataract 4, Multiple Types
Cataract 29 Cataract 42
Cataract 20, Multiple Types Cataract 1, Multiple Types
Cataract 30, Multiple Types Cataract 41
Cataract 6, Multiple Types Cataract 5, Multiple Types
Cataract 46, Juvenile-Onset Cataract 40
Cataract 10, Multiple Types Cataract 24
Cataract 3, Multiple Types Cataract 14, Multiple Types
Cataract 9, Multiple Types Cataract 2, Multiple Types
Cataract 31, Multiple Types Cataract 25
Cataract 26, Multiple Types Cataract 27
Cataract 28 Cataract 35
Cataract 22, Multiple Types Cataract 18
Cataract 21, Multiple Types Cataract 23, Multiple Types
Cataract 11, Multiple Types Cataract 33, Multiple Types
Cataract 17, Multiple Types Cataract 12, Multiple Types
Cataract 47 Cataract 34, Multiple Types
Cataract 16, Multiple Types Cataract 36
Cataract 37 Cataract 38
Cataract 39, Multiple Types Cataract 15, Multiple Types
Cataract 19, Multiple Types Cataract 43
Cataract 44 Cataract 45
Cataract 30 Cataract 33
Cataract Congenital Autosomal Dominant Cataract, Total Congenital

Diseases related to Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 849)
# Related Disease Score Top Affiliating Genes
1 cataract 16, multiple types 34.5 CRYAA CRYGC CRYGD CRYGS GJA3 HSF4
2 cataract 9, multiple types 34.5 CRYAA GJA8
3 cataract 30, multiple types 34.5 CRYGC CRYGD GJA3 GJA8
4 cataract 1, multiple types 34.4 GJA3 GJA8
5 cataract microcornea syndrome 34.3 CRYAA CRYGC CRYGD GJA8
6 cerulean cataract 34.2 CRYGD CTRCT37
7 cataract 24 34.2 CRYAA CRYBB3 CTAA2
8 cataract 44 34.2 CRYAA GJA8 HSF4 LIM2
9 cataract 25 34.2 CRYGS CTRCT25 GJA8
10 cataract 29 34.2 CRYGD CTRCT29
11 cataract 14, multiple types 34.1 GJA3 GJA8
12 nuclear senile cataract 34.0 CRYAA CRYGD CRYGS
13 posterior polar cataract 33.9 BFSP1 CRYGD GJA3
14 mature cataract 33.8 CRYAA CRYGS
15 early-onset nuclear cataract 33.6 BFSP1 CRYAA CRYBB3 CRYGC CRYGD GJA3
16 senile cataract 33.5 BFSP1 CRYAA
17 presbyopia 30.9 CRYAA CRYGS
18 lens disease 30.7 CRYAA CRYGS GJA3 GJA8
19 hyperferritinemia with or without cataract 12.4
20 cataract 4, multiple types 12.4
21 cataract 11, multiple types 12.3
22 cataract 2, multiple types 12.3
23 cataract 40 12.3
24 cataract 5, multiple types 12.3
25 cataract 21, multiple types 12.3
26 cataract 8, multiple types 12.3
27 cataract 6, multiple types 12.3
28 cataract 3, multiple types 12.2
29 cataract 17, multiple types 12.2
30 cataract 22, multiple types 12.2
31 cataract 10, multiple types 12.2
32 microphthalmia, isolated, with cataract 1 12.2
33 cataract 18 12.2
34 cataract 23, multiple types 12.2
35 cataract 31, multiple types 12.2
36 congenital cataracts, facial dysmorphism, and neuropathy 12.2
37 cataract 34, multiple types 12.2
38 cataract 7 12.2
39 cataract 32, multiple types 12.1
40 cataract 41 12.1
41 cataract 38 12.1
42 myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay 12.1
43 cataract 26, multiple types 12.1
44 cataract 39, multiple types 12.1
45 cataract 46, juvenile-onset 12.1
46 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 12.1
47 cataract 19, multiple types 12.1
48 cataract 12, multiple types 12.1
49 cataract 35 12.1
50 cataract 37 12.1

Graphical network of the top 20 diseases related to Cataract:



Diseases related to Cataract

Symptoms & Phenotypes for Cataract

MGI Mouse Phenotypes related to Cataract:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.23 BFSP1 CRYGC CRYGD CRYGS GJA3 GJA8

Drugs & Therapeutics for Cataract

PubMedHealth treatment related to Cataract: 59

Some people can compensate for the vision loss, temporarily or even in the longer term, by wearing glasses or contact lenses. There are no medications for the treatment of cataracts.The only effective treatment is surgery. Cataract surgery involves removing the cloudy lens and replacing it with a new, artificial lens. The lens capsule – an elastic membrane surrounding the lens of the eye – is left in the eye during surgery. Only the inner core and the outer cortex of the lens are broken up into small pieces using ultrasound. The pieces are then sucked out of the eye through a small cut. This procedure, called phacoemulsification, is the standard technique in Germany and some other countries. Once the lens has been removed, an artificial lens is implanted into the lens capsule.Whether and when surgery is an appropriate treatment option is very much a personal decision. The extent to which vision loss is affecting someone’s life will play a very important role. Another factor to consider is the presence of other (eye) conditions, which could affect the outcome of cataract surgery.

Drugs for Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 398)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4,Phase 1,Phase 2 60142-96-3 3446
2
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 1,Phase 2 56-12-2 119
3
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
4
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
5
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 151096-09-2, 354812-41-2 152946
6
Norgestimate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 35189-28-7 6540478
7
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
8
Loteprednol Approved Phase 4,Phase 3 129260-79-3, 82034-46-6 9865442 444025
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
11
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
12
Nepafenac Approved, Investigational Phase 4,Phase 3,Phase 2 78281-72-8 151075
13
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1 9004-61-9 53477741 24759
14
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
16
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2 32986-56-4 36294 5496
17
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
18
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
19
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
20
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 46507594 772
21
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
22
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
23
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 1 137-58-6 3676
24
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
25
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 216974-75-3
26
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
27
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
28
Dalteparin Approved Phase 4 9005-49-6
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
31
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
32
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
33
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
34 Homatropine Approved Phase 4 87-00-3
35
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
36
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
37 Racepinephrine Approved Phase 4,Phase 2 329-65-7
38
Dinoprostone Approved Phase 4 363-24-6 5280360
39
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
40
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
41
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
42
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
43
Gatifloxacin Approved, Investigational Phase 4,Phase 1 112811-59-3 5379
44
Vancomycin Approved Phase 4,Phase 3 1404-90-6 14969 441141
45
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
46
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2 155206-00-1 5311027
47
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Phase 2 85721-33-1 2764
48
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
49
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 38396-39-3, 2180-92-9 2474
50
Ethanol Approved Phase 4 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 1080)

# Name Status NCT ID Phase Drugs
1 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
2 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
3 Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Unknown status NCT01455467 Phase 4
4 A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. Unknown status NCT00326066 Phase 4
5 Effect of Gabapentin on Pain of the Second Cataract Surgery Unknown status NCT02127853 Phase 4 gabapentin;placebo
6 A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery Unknown status NCT01296542 Phase 4
7 Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens Unknown status NCT01615861 Phase 4
8 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
9 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4 Moxifloxacin;besifloxacin
10 Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification Unknown status NCT01193504 Phase 4 Pred Forte;Lotemax
11 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
12 Clinical Investigation of the Modified Rayner Monofocal Aspheric 600C (With Axis Marks) Intraocular Lens Unknown status NCT02378636 Phase 4
13 Efficacy of Subtenon's Block With Olive Tipped Cannula Unknown status NCT01019018 Phase 4
14 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
15 Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies Unknown status NCT00865540 Phase 4 prednisolone acetate 1%;ketorolac tromethamine 0.4%;nepafenac 0.1%;methylcellulose 0.5%
16 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
17 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
18 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
19 PRedictive Factors and Changes From Treatment in Idiopathic Polypoidal Choroidal Vasuclopathy Versus Central Serous Chorioretinopathy Versus Neovascular Age Related Macular Degeneration With afLibercept Unknown status NCT02681783 Phase 4 aflibercept
20 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
21 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
22 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
23 IntraVitreal Triamcinolone Acetonide: Preventing Raised Eye-pressure by Tracking Elevations After Topical Steroids Unknown status NCT00744666 Phase 4 Prednisolone 1% topical eye drops
24 Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema Unknown status NCT02399657 Phase 4 Intravitreal dexamethasone 0.7mg implant
25 Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery Completed NCT02023437 Phase 4
26 A Single Centre Study to Analyze Cataract Surgery Following Femtosecond Laser-Assisted and Manual Cataract Surgery Completed NCT01769313 Phase 4
27 Aphakia Versus Pseudophakia in Children Under 2 Years Undergoing Bilateral Congenital Cataract Surgery Completed NCT01297153 Phase 4
28 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
29 Size Progression of Macular Degeneration After Cataract Surgery Completed NCT01165801 Phase 4
30 To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery. Completed NCT00763360 Phase 4 Healon;Amvisc Plus
31 Clinical Trial on Anti-inflammatory Effect of Low-Molecular Weight Heparin in Pediatric Cataract Surgery Completed NCT00986076 Phase 4 Enoxaparin;Balanced Salt Solution
32 Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism Completed NCT01763151 Phase 4
33 Dexmedetomidine vs. Propofol for Cataract Surgery Completed NCT00786370 Phase 4 dexmedetomidine;Propofol;Dexemedetomidine
34 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed NCT00870103 Phase 4 Vigadexa (moxifloxacin 0.5% and dexamethasone 0.1%) eye drops
35 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed NCT01261975 Phase 4
36 2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery Completed NCT01455233 Phase 4 besivance;vigamox
37 Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema Completed NCT01546402 Phase 4 Dexamethasone Drug delivery system (Ozurdex)
38 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
39 Comparing Optical Coherence Tomography (OCT) and Visual Acuity Outcomes in Subjects Undergoing Cataract Surgery, Who Receive Xibrom Ophthalmic Solution and Standard Presurgical Care vs. Xibrom Ophthalmic Solution Plus Prednisolone Acetate 1% and Standard Completed NCT00698724 Phase 4 Xibrom, and Optive;Xibrom and Pred Forte
40 Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery Completed NCT00575380 Phase 4 AzaSite Eye Drops;Vigamox Eye Drops
41 Laser Cataract Surgery With the Femtosecond Laser Technology Completed NCT01382823 Phase 4
42 Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery Completed NCT01542190 Phase 4 Ketorolac Tromethamine
43 Dispervise Ophthalmic Viscoelastic as an Agent to Ensure Watertight Wound Closure After Clear Corneal Cataract Incisions Completed NCT01298973 Phase 4 Viscoat;Saline
44 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed NCT02150460 Phase 4
45 Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients Completed NCT01859702 Phase 4 Moxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution
46 Clear Corneal Incisions and Arcuate Incisions Utilizing FemtoSecond Laser Technology for Cataract Surgery Completed NCT01383057 Phase 4
47 Determination of Optimum Duration of Treatment With Bromfenac (Xibrom) Eyedrops Following Cataract Surgery Completed NCT00758199 Phase 4 Bromfenac;Moxifloxacin hydrochloride;Prednisolone Acetate
48 Influence of Two Different Preloaded Intraocular Lens (IOLs) on Posterior Capsule Opacification Completed NCT00673803 Phase 4
49 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
50 Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction Completed NCT00720005 Phase 4

Search NIH Clinical Center for Cataract

Cochrane evidence based reviews: cataract

Genetic Tests for Cataract

Genetic tests related to Cataract:

# Genetic test Affiliating Genes
1 Cataract 28

Anatomical Context for Cataract

MalaCards organs/tissues related to Cataract:

38
Eye, Endothelial, Testes, Bone, Liver, Bone Marrow, Retina
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Cataract:
# Tissue Anatomical CompartmentCell Relevance
1 Eye Lens Affected by disease

Publications for Cataract

Articles related to Cataract:

(show top 50) (show all 2989)
# Title Authors Year
1
Case 4-2018: A Newborn with Thrombocytopenia, Cataracts, and Hepatosplenomegaly. ( 29414276 )
2018
2
UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2 and ERK1/2 pathways in cataract. ( 29436594 )
2018
3
Bacteriology and cefuroxime-resistance in endophthalmitis following cataract surgery before and after the introduction of prophylactic intracameral cefuroxime: a retrospective single-centre study. ( 29432821 )
2018
4
Evaluation of a hub-and-spoke model for the delivery of femtosecond laser-assisted cataract surgery within the context of a large randomised controlled trial. ( 29436401 )
2018
5
Phacoemulsification cataract surgery in patients receiving novel oral anticoagulant medications. ( 29435797 )
2018
6
Beyond monetary benefits of restoring sight in Vietnam: Evaluating well-being gains from cataract surgery. ( 29432447 )
2018
7
Cataract in a patient with 47,XYY sex chromosome aneuploidy. ( 29397244 )
2018
8
A Missense Mutation in GJA8 Encoding Connexin 50 in a Chinese Pedigree with Autosomal Dominant Congenital Cataract. ( 29434075 )
2018
9
Blindness, low vision and cataract surgery outcome among adults in Hohhot of Inner Mongolia: a Rapid Assessment of Avoidable Blindness (RAAB) study. ( 29439090 )
2018
10
The role of Dexamethasone in clinical pharmaceutical treatment for patients with cataract surgery. ( 29434822 )
2018
11
Effect of femtosecond laser on efficiency of cataract surgery in public setting. ( 29426442 )
2018
12
A Simple Method of Cataract Induction in Adult Zebrafish. ( 29437550 )
2018
13
Optical Properties Influence Visual Cortical Functional Resolution After Cataract Surgery and Both Dissociate From Subjectively Perceived Quality of Vision. ( 29450542 )
2018
14
Cataract surgery in patients with glaucoma drainage implants: the hooked tube technique. ( 29442246 )
2018
15
Choroidal thickness changes following cataract surgery using swept source optical coherence tomography. ( 29426443 )
2018
16
Prevalence of corneal astigmatism before cataract surgery in Western Indian Population. ( 29386726 )
2018
17
Changes in shape and astigmatism of total, anterior, and posterior cornea after long versus short clear corneal incision cataract surgery. ( 29395715 )
2018
18
Audit of cataract surgery in Cadiz: visual outcomes and complications. ( 29433842 )
2018
19
Enhancement and restoration of non-uniform illuminated Fundus Image of Retina obtained through thin layer of cataract. ( 29428069 )
2018
20
Three-Dimensional Cataract Crystalline Lens Imaging With Swept-Source Optical Coherence Tomography. ( 29435589 )
2018
21
Using the Postoperative Visual Acuity to Monitor the Quality of Cataract Surgery: Does the Day One Visual Acuity following Cataract Surgery Correlate with the Final Visual Acuity? ( 28936053 )
2017
22
Combined Phacoemulsification and Intravitreal Dexamethasone Implant (OzurdexAr) in Diabetic Patients with Coexisting Cataract and Diabetic Macular Edema. ( 28884024 )
2017
23
Survival analysis of visual improvement after cataract surgery in advanced retinitis pigmentosa. ( 28776592 )
2017
24
Risk Factors for Posterior Subcapsular Cataract in Retinitis Pigmentosa. ( 28492871 )
2017
25
Ciliary body melanoma manifesting as unilateral ocular hypertension and early cataract. ( 29024006 )
2017
26
Effects of adjuvant omega-3 fatty acid supplementation on dry eye syndrome following cataract surgery: A randomized clinical trial. ( 28367524 )
2017
27
The risk of ischemic optic neuropathy post phacoemulsification cataract surgery. ( 29184605 )
2017
28
Next-generation sequencing for D47N mutation in Cx50 analysis associated with autosomal dominant congenital cataract in a six-generation Chinese family. ( 28526010 )
2017
29
Change of Capsulotomy Over 1 Year in Femtosecond Laser-Assisted Cataract Surgery and Its Impact on Visual Quality. ( 28068446 )
2017
30
Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. ( 28548647 )
2017
31
Rasch analysis of the hospital anxiety and depression scale among Chinese cataract patients. ( 28949992 )
2017
32
Functional results of cataract surgery in the treatment of phacomorphic glaucoma. ( 29450399 )
2017
33
Different-sized incisions for phacoemulsification in age-related cataract. ( 28931202 )
2017
34
Segregation of aA novel p.(Ser270Tyr) MAF mutation and p.(Tyr56a89) CRYGD variant in a family with dominantly inherited congenital cataracts. ( 28849415 )
2017
35
Aberrant Epigenetic Alterations of Glutathione-S-Transferase P1 in Age-Related Nuclear Cataract. ( 27348130 )
2017
36
Cerebrotendinous xanthomatosis: early diagnosis on the basis of juvenile cataracts. ( 29079218 )
2017
37
The impact of different mutations at Arg54 on structure, chaperone-like activity and oligomerization state of human I+A-crystallin: The pathomechanism underlying congenital cataract-causing mutations R54L, R54P and R54C. ( 28179137 )
2017
38
Cataract development in children with Coats disease: risk factors and outcome. ( 29289688 )
2017
39
Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis. ( 27840165 )
2017
40
Outcomes of cataract surgery with/without vitrectomy in patients with pars planitis and immunosuppressive therapy. ( 28396945 )
2017
41
Bioinformatics Study of m.9053G>A Mutation at the ATP6 Gene in Relation to Type 2 Diabetes Mellitus and Cataract Diseases. ( 28932107 )
2017
42
Cataract surgery in uveitis: a multicentre database study. ( 28043984 )
2017
43
A review of results after implantation of a secondary intraocular lens to correct residual refractive error after cataract surgery. ( 29042749 )
2017
44
TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract. ( 28392351 )
2017
45
Association of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract. ( 28298860 )
2017
46
A Case of Bilateral Pigment Dispersion Syndrome Following Many Years of Uninterrupted Treatment With Atropine 1% for Bilateral Congenital Cataracts. ( 28671922 )
2017
47
Interaction of AR and iNOS in lens epithelial cell: A new pathogenesis and potential therapeutic targets of diabetic cataract. ( 28108234 )
2017
48
Pinus densiflora bark extract prevents selenite-induced cataract formation in the lens of Sprague Dawley rat pups. ( 28943754 )
2017
49
Sequence specific (1)H, (13)C and (15)N resonance assignments of a cataract-related variant G57W of human I^S-crystallin. ( 28936763 )
2017
50
Aqueous misdirection masked as myopia after cataract surgery. ( 28774542 )
2017

Variations for Cataract

ClinVar genetic disease variations for Cataract:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Cataract from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 86882 14 67000000 106368585 Copy number cataract
2 89231 15 17000000 100338915 Copy number cataract
3 106728 17 1 11200000 Copy number cataract

Expression for Cataract

Search GEO for disease gene expression data for Cataract.

Pathways for Cataract

Pathways related to Cataract according to KEGG:

36
# Name Kegg Source Accession
1 Protein processing in endoplasmic reticulum hsa04141

GO Terms for Cataract

Cellular components related to Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJA3 GJA8
2 connexin complex GO:0005922 8.62 GJA3 GJA8

Biological processes related to Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.43 CRYAA GJA8 HSF4
2 camera-type eye development GO:0043010 9.33 GJA8 HSF4 LIM2
3 lens development in camera-type eye GO:0002088 9.26 CRYGD CRYGS GJA8 LIM2
4 visual perception GO:0007601 9.17 CRYAA CRYBB3 CRYGC CRYGD GJA3 GJA8

Molecular functions related to Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.17 BFSP1 CRYAA CRYBB3 CRYGC CRYGD CRYGS
2 gap junction channel activity GO:0005243 8.96 GJA3 GJA8

Sources for Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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