MCID: CTR002
MIFTS: 53

Cataract malady

Summaries for Cataract

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all americans either have a cataract or have had cataract surgery. a cataract can occur in either or both eyes. it cannot spread from one eye to the other. common symptoms are blurry vision colors that seem faded glare - headlights, lamps or sunlight may seem too bright. you may also see a halo around lights. not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute

MalaCards: Cataract is related to senile cataract and posterior polar cataract. An important gene associated with Cataract is NHS (Nance-Horan syndrome (congenital cataracts and dental anomalies)), and among its related pathways is Membrane Trafficking. The compounds cp-49 and mp 26 have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotype vision/eye.

Wikipedia:63 A cataract is a clouding of the lens inside the eye which leads to a decrease in vision. It is the most... more...

Aliases & Classifications for Cataract

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 27ICD9CM, 34MeSH, 60UMLS, 56SNOMED-CT
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Aliases & Descriptions:

cataract 8 44 33


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Disease Ontology8 DOID:83
ICD9CM27 366.8
MeSH34 D002386

Related Diseases for Cataract

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cataract 4, Multiple Types family:

cataract Cataract, Total Congenital
Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 2, Multiple Types Cataract 12, Multiple Types
Cataract 20, Multiple Types Cataract 26, Multiple Types
Cataract 36 Cataract 11, Multiple Types
Cataract 16, Multiple Types Cataract 15, Multiple Types
Cataract 14, Multiple Types Cataract 32, Multiple Types
Cataract, Congenital Cataract 25
Cataract 5, Multiple Types Cataract 10, Multiple Types
Cataract 7 Cataract 19
Cataract 33 Cataract 31, Multiple Types
Cataract 9, Multiple Types Cataract 17, Multiple Types
Cataract 3, Multiple Types Cataract 23

Diseases related to Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 768)
idRelated DiseaseScoreTop Affiliating Genes
1senile cataract31.3CRYBB2, CRYAA, CRYGS, GJA8
2posterior polar cataract30.8CRYBA1, PITX3, BFSP1
3microphthalmia30.5SIX6, PITX3, CRYAA, GJA8
4cataract 4, multiple types30.3FTL, GJA8, CRYGD, CRYAA, BFSP1
5cataract 3, multiple types30.1CRYGC, CRYBB2
6cataract, congenital30.1GALK1, BFSP2, PITX3, CRYBA1, CRYBB2, CRYBB3
7cataracts, autosomal dominant30.0CRYBB2, CRYAA, GJA8
8diabetic cataract10.8
9glaucoma10.7
10endophthalmitis10.6
11astigmatism10.6
12retinitis10.5
13mature cataract10.4
14cystoid macular edema10.4
15aniridia10.4
16uveitis10.4
17hyperferritinemia cataract syndrome10.4
18hypomyelination and congenital cataract10.4
19retinal detachment10.3
20exfoliation syndrome10.3
21acute endophthalmitis10.3
22refractive error10.3
23corneal edema10.3
24immature cataract10.3
25coloboma10.3
26eye disease10.3
27myopia10.3
28neuropathy10.3
29iridocyclitis10.3
30congenital cataracts, facial dysmorphism, and neuropathy10.3
31primary angle-closure glaucoma10.3
32open-angle glaucoma10.3
33cerebrotendinous xanthomatosis10.2
34corneal dystrophy10.2
35cerulean cataract10.2
36microcephaly10.2
37diabetic macular edema10.2
38cataract 1, multiple types10.2
39cataract 10, multiple types10.2
40morgagni cataract10.2
41retinitis pigmentosa10.2
42phacolytic glaucoma10.2
43diabetic retinopathy10.2
44keratopathy10.2
45trichomegaly, cataract, and hereditary spherocytosis10.2
46myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay10.2
47age related macular degeneration10.2
48choroiditis10.2
49myotonic cataract10.2
50keratoconus10.2

Graphical network of the top 20 diseases related to Cataract:



Diseases related to cataract

Clinical Features for Cataract

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Drugs & Therapeutics for Cataract

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cataract

Drug clinical trials:

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Search NIH Clinical Center for Cataract

Search CenterWatch for Cataract

Genetic Tests for Cataract

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Anatomical Context for Cataract

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32MalaCards
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MalaCards organs/tissues related to Cataract:

32
Eye, Retina, Endothelial, Testes, Brain, Skin, Cortex, Heart, Kidney, T cells, Bone, Prostate, Thyroid, Liver, Skeletal muscle, Smooth muscle, Colon

Animal Models for Cataract or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539112.3TDRD7, BFSP2, BFSP1, GALK1, PITX3, CRYBA1

Publications for Cataract

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50PubMed
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Articles related to Cataract:

(show top 50)    (show all 2384)
idTitleAuthorsYear
1
Femtosecond laser assisted cataract surgery followed by coaxial phacoemulsification or microincisional cataract surgery: differences and advantages. (24310376)
2014
2
An analysis of ophthalmology trainees' perceptions of feedback for cataract surgery training. (24376339)
2014
3
Prevalence of corneal astigmatism before cataract surgery in Caucasian patients. (24366768)
2013
4
Prevalence of corneal astigmatism before cataract surgery in Chinese patients. (23141077)
2013
5
Scheimpflug corneal power measurements for intraocular lens power calculation in cataract surgery. (23810477)
2013
6
Ask the doctors. I had a small heart attack last year when I was undergoing an operation to remove part of my colon. I am doing fine in that regard, but now I need cataract surgery, and my ophthalmologist has sent me to my internist for "clearance" before surgery. Does this mean my risk for another heart attack is high? (23862202)
2013
7
Preoperative Consultations for Medicare Patients Undergoing Cataract Surgery. (24366269)
2013
8
Cataract as a phenotypic marker for a mutation in WFS1, the Wolfram syndrome gene. (21623591)
2012
9
Intraocular lens power calculations for cataract surgery after phototherapeutic keratectomy in granular corneal dystrophy type 2. (23062002)
2012
10
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. (22687477)
2012
11
Phacoemulsification in eyes with posterior polar cataract. (22920002)
2012
12
Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels. (22843197)
2012
13
Early postoperative intraocular pressure stability after combined 23-gauge sutureless vitrectomy and cataract surgery in patients with proliferative diabetic retinopathy. (22481480)
2012
14
The masquerades of a childhood ciliary body medulloepithelioma: a case of chronic uveitis, cataract, and secondary glaucoma. (22606494)
2012
15
Intracameral cefuroxime injection at the end of cataract surgery to reduce the incidence of endophthalmitis: French study. (22814043)
2012
16
A recurrent missense mutation in GJA3 associated with autosomal dominant cataract linked to chromosome 13q. (21897748)
2011
17
Endophthalmitis after cataract surgery in China, 1995-2009. (21855767)
2011
18
Approach to cataract with persistent hyperplastic primary vitreous. (21782083)
2011
19
Cerulean fundus: an unexpected complication of cataract surgery in an eye with aqueous misdirection. (20576781)
2010
20
Mutation analysis of congenital cataract in a Chinese family identified a novel missense mutation in the connexin 46 gene (GJA3). (20431721)
2010
21
Effect of three treatment protocols on acute ocular hypertension after phacoemulsification and aspiration of cataracts in dogs. (20149170)
2010
22
Identification of a novel CRYAB mutation associated with autosomal recessive juvenile cataract in a Saudi family. (19461931)
2009
23
Posterior vitreous detachment following cataract surgery. (18776863)
2009
24
Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families. (19390652)
2009
25
Retinitis pigmentosa associated with blepharophimosis, blue dot cataract and primary inferior oblique overaction: a new syndrome complex or consummate myotonic dystrophy? (19574710)
2009
26
Laser in situ keratomileusis versus lens-based surgery for correcting residual refractive error after cataract surgery. (18361976)
2008
27
Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome. (17561259)
2008
28
Change in astigmatism after temporal clear corneal cataract extraction in the pediatric population. (19478907)
2008
29
Combined cataract-glaucoma surgery using the intracanalicular Eyepass glaucoma implant: first clinical results of a prospective pilot study. (18242448)
2008
30
Congenital cataracts-facial dysmorphism-neuropathy. (16939648)
2006
31
Hypoplastic thyroid, growth hormone deficiency, corneal opacities, cataract and hyperkeratotic skin disease: a possible new ichthyosis syndrome associated with endocrinopathies. (15875205)
2005
32
Strabismus in senile cataract patients. (16213390)
2005
33
A missense mutation in the gammaD crystallin gene (CRYGD) associated with autosomal dominant "coral-like" cataract linked to chromosome 2q. (15041957)
2004
34
Null genotype of glutathione S-transferase M1 is associated with senile cataract susceptibility in non-smoker females. (15194507)
2004
35
Effectiveness of multifocal intraocular lenses to correct presbyopia after cataract surgery: a randomized controlled trial. (15465543)
2004
36
Further genetic heterogeneity for autosomal dominant human sutural cataracts. (12646746)
2003
37
A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. (12629167)
2003
38
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
39
Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells. (8664236)
1996
40
Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance]. (1908617)
1991
41
Nucleotide levels in human lens: regional distribution in different forms of senile cataract. (2920783)
1989
42
Nevus of ota with nevus of Ito--report of a case with cataract. (2778194)
1989
43
Senile cataract: survey on cataract patients undergoing cataract surgery, Japan. (2792527)
1989
44
Indo-US case-control study of senile cataract--design and development. (3691930)
1987
45
Sorbinil protection of lens protein components and cell hydration during diabetic cataract formation. (6803262)
1982
46
Acute phacolytic glaucoma with primary intraocular lens implantation after intracapsular cataract extraction. (7287575)
1981
47
Retinal aplasia in association with macular coloboma, keratoconus and cataract. (4765210)
1973
48
On the changes in the activity of glutathione reductase on the maturation of senile cataract. (13751487)
1961
49
Retinal detachments occurring in cataract associated with neurodermatitis. (14932558)
1952
50
SULPHUR METABOLISM IN SENILE CATARACT. (18169414)
1936

Genetic Variations for Cataract

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Expression for genes affiliated with Cataract

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cataract

Search GEO for disease gene expression data for Cataract.

Pathways for genes affiliated with Cataract

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53Reactome
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Pathways related to Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9GJA8, GJA3, FTL, CHMP4B

Compounds for genes affiliated with Cataract

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Cataract according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cp-494410.9BFSP1, BFSP2
2mp 264410.8GJA3, CRYAA
3gap 275910.8GJA3, GJA8
4carbenoxolone disodium5910.8GJA3, GJA8
5scrambled 10panx5910.7GJA3, GJA8
6carbenoxolone28 44 1112.7GJA8, GJA3
710panx5910.6GJA3, GJA8
8octanol28 2411.4GJA8, GJA3

GO Terms for genes affiliated with Cataract

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16Gene Ontology
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Cellular components related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.5BFSP1, GALK1, CRYBA1, CRYAA, CRYGC, CRYGD
2connexon complexGO:00592210.4GJA8, GJA3

Biological processes related to Cataract according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.7SIX6, BFSP2, CRYBA1, CRYBB2, CRYBB3, CRYAA
2lens development in camera-type eyeGO:00208811.2PITX3, CRYBA1, CRYGD, CRYGS, GJA8, NHS
3lens fiber cell differentiationGO:07030611.0TDRD7, MAF, CRYGD, PITX3
4camera-type eye developmentGO:04301010.8HSF4, CRYBB2, CRYGC
5lens morphogenesis in camera-type eyeGO:00208910.7TDRD7, PITX3
6lens fiber cell developmentGO:07030710.6BFSP1, BFSP2
7cell developmentGO:04846810.4MAF, HSF4

Molecular functions related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of eye lensGO:00521211.4CRYGS, CRYGD, CRYGC, CRYAA, CRYBB3, CRYBB2

Products for genes affiliated with Cataract

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  • Antibodies
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  • Antibodies

Sources for Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet