MCID: CTR002
MIFTS: 53

Cataract malady

Summaries for Cataract

About this section
Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 A cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all americans either have a cataract or have had cataract surgery. a cataract can occur in either or both eyes. it cannot spread from one eye to the other. common symptoms are blurry vision colors that seem faded glare - headlights, lamps or sunlight may seem too bright. you may also see a halo around lights. not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute

MalaCards: Cataract is related to senile cataract and posterior polar cataract. An important gene associated with Cataract is NHS (Nance-Horan syndrome (congenital cataracts and dental anomalies)), and among its related pathways is Membrane Trafficking. The compounds cp-49 and mp 26 have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotype vision/eye.

Wikipedia:63 A cataract is a clouding of the lens inside the eye which leads to a decrease in vision. It is the most... more...

Aliases & Classifications for Cataract

About this section
Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 27ICD9CM, 34MeSH, 60UMLS, 56SNOMED-CT
See all sources

Aliases & Descriptions:

cataract 8 44 33


External Ids:

Disease Ontology8 DOID:83
ICD9CM27 366.8
MeSH34 D002386

Related Diseases for Cataract

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cataract 4, Multiple Types family:

cataract Cataract, Total Congenital
Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 2, Multiple Types Cataract 12, Multiple Types
Cataract 20, Multiple Types Cataract 26, Multiple Types
Cataract 36 Cataract 11, Multiple Types
Cataract 16, Multiple Types Cataract 15, Multiple Types
Cataract 14, Multiple Types Cataract 32, Multiple Types
Cataract, Congenital Cataract 25
Cataract 5, Multiple Types Cataract 10, Multiple Types
Cataract 7 Cataract 19
Cataract 33 Cataract 31, Multiple Types
Cataract 9, Multiple Types Cataract 17, Multiple Types
Cataract 3, Multiple Types Cataract 23

Diseases related to Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 768)
idRelated DiseaseScoreTop Affiliating Genes
1senile cataract31.3CRYBB2, CRYAA, CRYGS, GJA8
2posterior polar cataract30.8CRYBA1, PITX3, BFSP1
3microphthalmia30.5SIX6, PITX3, CRYAA, GJA8
4cataract 4, multiple types30.3FTL, GJA8, CRYGD, CRYAA, BFSP1
5cataract 3, multiple types30.1CRYGC, CRYBB2
6cataract, congenital30.1GALK1, BFSP2, PITX3, CRYBA1, CRYBB2, CRYBB3
7cataracts, autosomal dominant30.0CRYBB2, CRYAA, GJA8
8diabetic cataract10.8
9glaucoma10.7
10endophthalmitis10.6
11astigmatism10.6
12retinitis10.5
13mature cataract10.4
14cystoid macular edema10.4
15aniridia10.4
16uveitis10.4
17hyperferritinemia cataract syndrome10.4
18hypomyelination and congenital cataract10.4
19retinal detachment10.3
20exfoliation syndrome10.3
21acute endophthalmitis10.3
22refractive error10.3
23corneal edema10.3
24immature cataract10.3
25coloboma10.3
26eye disease10.3
27myopia10.3
28neuropathy10.3
29iridocyclitis10.3
30congenital cataracts, facial dysmorphism, and neuropathy10.3
31primary angle-closure glaucoma10.3
32open-angle glaucoma10.3
33cerebrotendinous xanthomatosis10.2
34corneal dystrophy10.2
35cerulean cataract10.2
36microcephaly10.2
37diabetic macular edema10.2
38cataract 1, multiple types10.2
39cataract 10, multiple types10.2
40morgagni cataract10.2
41retinitis pigmentosa10.2
42phacolytic glaucoma10.2
43diabetic retinopathy10.2
44keratopathy10.2
45trichomegaly, cataract, and hereditary spherocytosis10.2
46myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay10.2
47age related macular degeneration10.2
48choroiditis10.2
49myotonic cataract10.2
50keratoconus10.2

Graphical network of the top 20 diseases related to Cataract:



Diseases related to cataract

Clinical Features for Cataract

About this section

Drugs & Therapeutics for Cataract

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cataract

Drug clinical trials:

Search ClinicalTrials for Cataract

Search NIH Clinical Center for Cataract

Search CenterWatch for Cataract

Genetic Tests for Cataract

About this section

Anatomical Context for Cataract

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cataract:

32
Eye, Retina, Endothelial, Testes, Skin, Brain, Cortex, Heart, Kidney, T cells, Bone, Prostate, Thyroid, Liver, Smooth muscle, Colon, Skeletal muscle

Animal Models for Cataract or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539112.3TDRD7, BFSP2, BFSP1, GALK1, PITX3, CRYBA1

Publications for Cataract

About this section
Sources:
50PubMed
See all sources

Articles related to Cataract:

(show top 50)    (show all 2384)
idTitleAuthorsYear
1
Femtosecond laser cataract surgery: challenging cases. (24248096)
2014
2
Pediatric cataract surgery in Madagascar. (24326800)
2014
3
Relationship between dietary macronutrient intake and the risk of age-related cataract in middle-aged and elderly patients in northeast China. (24392329)
2013
4
Anterior capsular phimosis occluding the capsulorhexis opening after cataract surgery in a diabetic patient with high hemoglobin A1C. (23448558)
2013
5
Outcomes of Repeat Descemetopexy in Post-Cataract Surgery Descemet Membrane Detachment. (24246573)
2013
6
Quantification of intraocular IFNgamma and IgG in cataract and diabetes. (23837227)
2013
7
Deprivation amblyopia and congenital hereditary cataract. (24138041)
2013
8
The effect of age and cataract surgery on macular pigment optic density: a cross-sectional, comparative study. (23873256)
2013
9
Intraocular and orbital hemorrhage in a patient with dengue fever during cataract surgery. (24114132)
2013
10
Disparities in cataract surgery between Aboriginal and non-Aboriginal people in New South Wales, Australia. (24299196)
2013
11
Toric intraocular lens implantation for correction of astigmatism in cataract patients with corneal ectasia. (24348406)
2013
12
Discussion of changes in intraocular pressure and anterior segment morphometry following phacoemulsification cataract surgery-reply. (23753885)
2012
13
Eye conditions and blindness in children: priorities for research, programs, and policy with a focus on childhood cataract. (22944758)
2012
14
Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery. (23055681)
2012
15
Results at seven years after the use of intracamerular cefazolin as an endophthalmitis prophylaxis in cataract surgery. (22272570)
2012
16
Cataract-associated mutant E107A of human gammaD-crystallin shows increased attraction to alpha-crystallin and enhanced light scattering. (21173272)
2011
17
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. (21271438)
2011
18
A missense mutation in CRYBA4 associated with congenital cataract and microcornea. (20577656)
2010
19
Bilateral cataract in a subject carrying a C to A transition in the L ferritin promoter region. (19254706)
2009
20
The combination of intravitreal bevacizumab and phacoemulsification surgery in patients with cataract and coexisting diabetic macular edema. (19232012)
2009
21
Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation. (18227073)
2008
22
A novel mutation in GJA8 associated with jellyfish-like cataract in a family of Indian origin. (18334946)
2008
23
Retinitis pigmentosa associated with blepharophimosis, blue dot cataract and primary inferior oblique overaction: a new syndrome complex? (17322611)
2007
24
Phacoemulsification with viscodissection in posterior polar cataract: minimizing risk of posterior capsule tear. (17984504)
2007
25
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. (17240813)
2006
26
AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. (16728471)
2006
27
Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. (15682043)
2005
28
Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. (15105821)
2005
29
Cataract surgery in patients with Fuchs' corneal dystrophy: expanding recommendations for cataract surgery without simultaneous keratoplasty. (15745771)
2005
30
Revival of inactive glyceraldehyde 3-phosphate dehydrogenase in human cataract lenses by reduction. (15183105)
2004
31
Dense cataract and microphthalmia--new spontaneous mutation in BALB/c mice. (15253273)
2004
32
Cataract surgery in Senior-Loken syndrome is beneficial despite severe retinopathy. (12439678)
2002
33
The effects of simulated cataract on reading with normal vision and simulated central scotoma. (10755163)
1999
34
Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. (10485530)
1999
35
Effects of xylose on monkey lenses in organ culture: a model for study of sugar cataracts in a primate. (9702179)
1998
36
Cerebellar dysplasia and unilateral cataract in Marinesco-SjAPgren syndrome. (8703231)
1996
37
X-linked dominant chondrodysplasia punctata/ichthyosis/cataract syndrome in males. (7677158)
1995
38
Proximal myotonic myopathy: a new dominant disorder with myotonia, muscle weakness, and cataracts. (8058147)
1994
39
Beneficial effects of acarbose on daily plasma glucose profile and cataract development in sand rats. (7958047)
1994
40
Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)
1992
41
Orbital cellulitis and cavernous sinus thrombosis after cataract extraction and lens implantation. (1416632)
1992
42
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1821625)
1991
43
Lens opacity induced by lipid peroxidation products as a model of cataract associated with retinal disease. (2742866)
1989
44
Cataracts, chronic uveitis, and retinal vasculitis in BehAset's disease. (3826281)
1987
45
Unilateral skin lesions, cataracts, optic glioma and retardation--a variant of the epidermal nevus syndrome? (7128888)
1982
46
Variations of lens thickness in relation to biomicroscopic types of human senile cataract. (419966)
1979
47
Lactose intolerance associated with cataracts. (759181)
1979
48
Galactokinase deficiency and cataract formation. (5074466)
1972
49
The Treatment of a Case of Cyclo-Iritis Following Senile Cataract Extraction. (20316669)
1928
50
SPONTANEOUS ABSORPTION OF MATURE SENILE CATARACT. (18168537)
1926

Genetic Variations for Cataract

About this section

Expression for genes affiliated with Cataract

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cataract

Search GEO for disease gene expression data for Cataract.

Pathways for genes affiliated with Cataract

About this section
Sources:
53Reactome
See all sources

Pathways related to Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9GJA8, GJA3, FTL, CHMP4B

Compounds for genes affiliated with Cataract

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Cataract according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cp-494410.9BFSP1, BFSP2
2mp 264410.8GJA3, CRYAA
3gap 275910.8GJA3, GJA8
4carbenoxolone disodium5910.8GJA3, GJA8
5scrambled 10panx5910.7GJA3, GJA8
6carbenoxolone28 44 1112.7GJA8, GJA3
710panx5910.6GJA3, GJA8
8octanol28 2411.4GJA8, GJA3

GO Terms for genes affiliated with Cataract

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.5BFSP2, BFSP1, GALK1, CRYBA1, CRYAA, CRYGC
2connexon complexGO:00592210.4GJA3, GJA8

Biological processes related to Cataract according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.7CRYBB3, GJA8, SIX6, CRYGD, CRYGC, CRYAA
2lens development in camera-type eyeGO:00208811.2NHS, GJA8, PITX3, CRYBA1, CRYGD, CRYGS
3lens fiber cell differentiationGO:07030611.0MAF, CRYGD, PITX3, TDRD7
4camera-type eye developmentGO:04301010.8CRYBB2, CRYGC, HSF4
5lens morphogenesis in camera-type eyeGO:00208910.7TDRD7, PITX3
6lens fiber cell developmentGO:07030710.6BFSP1, BFSP2
7cell developmentGO:04846810.4HSF4, MAF

Molecular functions related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of eye lensGO:00521211.4CRYGS, CRYGD, CRYGC, CRYAA, CRYBB3, CRYBB2

Products for genes affiliated with Cataract

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cataract

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet