MCID: CTR002
MIFTS: 58

Cataract malady

Genetic diseases, Rare diseases, Eye diseases, Fetal diseases, Cancer diseases categories

Summaries for Cataract

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MedlinePlus:34 A cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all americans either have a cataract or have had cataract surgery. a cataract can occur in either or both eyes. it cannot spread from one eye to the other. common symptoms are blurry vision colors that seem faded glare - headlights, lamps or sunlight may seem too bright. you may also see a halo around lights. not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute

MalaCards based summary: Cataract is related to senile cataract and posterior polar cataract. An important gene associated with Cataract is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Gap junction trafficking and Cell adhesion Gap junctions. The compounds gap 27 and carbenoxolone disodium have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotype vision/eye.

Disease Ontology:10 A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.

Wikipedia:65 A cataract is a clouding of the lens inside the eye which leads to a decrease in vision. It is the most... more...

Aliases & Classifications for Cataract

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Cataract, Aliases & Descriptions:

Name: Cataract 32 10 45 34


Classifications:



External Ids:

Disease Ontology10 DOID:83
MeSH35 D002386
ICD9CM29 366.8

Related Diseases for Cataract

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Diseases in the Cataract family:

Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 2, Multiple Types Cataract 4, Multiple Types
Cataract 42 Cataract 12, Multiple Types
Cataract 20, Multiple Types Cataract 41
Cataract 26, Multiple Types Cataract 36
Cataract 11, Multiple Types Cataract 16, Multiple Types
Cataract 15, Multiple Types Cataract 14, Multiple Types
Cataract 32, Multiple Types Cataract 25
Cataract 5, Multiple Types Cataract 21, Multiple Types
Cataract 10, Multiple Types Cataract 7
Cataract 19 Cataract 33
Cataract 31, Multiple Types Cataract 9, Multiple Types
Cataract 17, Multiple Types Cataract 3, Multiple Types
Cataract 23 Cataract 39, Multiple Types, Autosomal Dominant
Cataract 18, Autosomal Recessive Cataract 38, Autosomal Recessive
Cataract 22, Autosomal Recessive Cataract Congenital Autosomal Dominant
Cataract, Total Congenital Cataracts, Autosomal Recessive
Cataract, Autosomal Dominant, Multiple Types 1 Foxe3-Related Cataracts, Autosomal Dominant

Diseases related to Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 895)
idRelated DiseaseScoreTop Affiliating Genes
1senile cataract31.4GJA8, CRYAA, CRYGS
2posterior polar cataract30.9CRYBA1, BFSP1
3nuclear cataract30.8BFSP1, FTL, CRYGD, CRYAA, GJA8
4microphthalmia30.6GJA8, SIX6, CRYAA
5cataract 9, multiple types30.5GJA8, CRYAA
6diabetic cataract10.7
7endophthalmitis10.7
8hyperferritinemia-cataract syndrome10.7
9astigmatism10.7
10retinitis10.6
11aniridia10.5
12uveitis10.5
13mature cataract10.4
14hypomyelination and congenital cataract10.4
15cerulean cataract10.4
16endotheliitis10.4
17mental retardation10.4
18corneal edema10.4
19refractive error10.4
20exfoliation syndrome10.4
21retinal detachment10.4
22pulverulent cataract10.4
23coloboma10.4
24congenital cataracts, facial dysmorphism, and neuropathy10.4
25nance-horan syndrome10.4
26optic atrophy 3 with cataract10.4
27neuropathy10.4
28immature cataract10.3
29myopia10.3
30cataract-glaucoma10.3
31blindness10.3
32eye disease10.3
33iridocyclitis10.3
34primary angle-closure glaucoma10.3
35cerebrotendinous xanthomatosis10.3
36acute endophthalmitis10.3
37cataract microcornea syndrome10.3
38retinitis pigmentosa10.3
39open-angle glaucoma10.3
40microphthalmia cataract10.3
41cataract 1, multiple types10.3
42ataxia10.3
43cataract 6, multiple types10.3
44corneal dystrophy10.3
45cardiomyopathy cataract hip spine disease10.3
46cataract ataxia deafness10.3
47cataract 8, multiple types10.2
48cataract 5, multiple types10.2
49keratopathy10.2
50microcephaly10.2

Graphical network of the top 20 diseases related to Cataract:



Diseases related to cataract

Symptoms for Cataract

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Drugs & Therapeutics for Cataract

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Drug clinical trials:

Search ClinicalTrials for Cataract

Search NIH Clinical Center for Cataract

Genetic Tests for Cataract

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Anatomical Context for Cataract

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MalaCards organs/tissues related to Cataract:

33
Eye, Retina, Endothelial, Testes, Brain, Heart, Skin, Cortex, Kidney, Bone, Prostate, T cells, Smooth muscle, Skeletal muscle, Colon, Liver, Thyroid, Neutrophil

Animal Models for Cataract or affiliated genes

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MGI Mouse Phenotypes related to Cataract:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053916.1GJA3, EPHA2, LIM2, BFSP1, MAF, CRYGS

Publications for Cataract

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Articles related to Cataract:

(show top 50)    (show all 2509)
idTitleAuthorsYear
1
New options for combined cataract and glaucoma surgery. (24389806)
2014
2
A Novel Capsulorhexis Technique in White Cataract Surgery. (24409937)
2014
3
The cataract-associated V41M mutant of human I^S-crystallin shows specific structural changes that directly enhance local surface hydrophobicity. (24287181)
2014
4
Restoration of severely impaired eyesight in an adolescent with down syndrome and bilateral cataract in South Asia. (24403902)
2013
5
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
6
Predictability of intraocular lens power calculation formulae in infantile eyes with unilateral congenital cataract: results from the Infant Aphakia Treatment Study. (24011524)
2013
7
Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion. (24120416)
2013
8
Anterior chamber flare after femtosecond laser-assisted cataract surgery. (23850229)
2013
9
Ethanol extract of Moringa oliefera prevents in vitro glucose induced cataract on isolated goat eye lens. (24008789)
2013
10
Capsular bag stability and posterior capsule opacification of a plate-haptic design microincision cataract surgery intraocular lens: 3-year results of a randomised trial. (24064942)
2013
11
Relationship between dietary macronutrient intake and the risk of age-related cataract in middle-aged and elderly patients in northeast China. (24392329)
2013
12
Prevalence of corneal astigmatism before cataract surgery in Caucasian patients. (24366768)
2013
13
Significance of axial length monitoring in children with congenital cataract and update of measurement methods. (24396964)
2013
14
23- vs 20-gauge pars plana vitrectomy in combination with bimanual microincisional cataract surgery (b-MICS) for the treatment of macular hole and cataract as a one-step procedure. (23743530)
2013
15
Cost-utility of cataract surgery: the real issues. (24246823)
2013
16
OPA3--related autosomal dominant optic atrophy and cataract with ataxia and areflexia. (22797356)
2012
17
Postoperative astigmatism in the second eye undergoing cataract surgery. (21402984)
2011
18
Aniridia rings implantation for treatment of congenital aniridia combined with cataract surgery: a case report. (22553596)
2010
19
A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. (20142846)
2010
20
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
21
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
22
AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice. (19619312)
2009
23
Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation. (18227073)
2008
24
The EPHA2 gene is associated with cataracts linked to chromosome 1p. (19005574)
2008
25
Crystallin gene mutations in Indian families with inherited pediatric cataract. (18587492)
2008
26
Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. (17653041)
2007
27
Safety and efficacy of manual small incision cataract surgery for phacolytic glaucoma. (17322465)
2007
28
Actinomyces neuii subspecies anitratus chronic endophthalmitis after cataract surgery. (17534833)
2007
29
Conductive keratoplasty to correct residual hyperopia after cataract surgery. (16931254)
2006
30
Orbital cellulitis following cataract surgery. (16033368)
2005
31
Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin. (15709761)
2005
32
Risk factors of acute endophthalmitis after cataract extraction: a case-control study in Asian eyes. (14693767)
2004
33
Refinement of the X-linked cataract locus (CXN) and gene analysis for CXN and Nance-Horan syndrome (NHS). (15370543)
2004
34
Cataracts and glaucoma in patients with oculocerebrorenal syndrome. (12963605)
2003
35
Cataract in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD). (12660866)
2003
36
Localization of cell apoptosis in the opaque portion of anterior polar cataract and anterior capsulotomy margin. (12660487)
2003
37
Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract. (12009421)
2002
38
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
39
Review: Age-related cataract: immunity and lens epithelium-derived growth factor (LEDGF). (10803429)
2000
40
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
41
Progressive juvenile-onset punctate cataracts caused by mutation of the gamma-D-crystallin gene. (9927684)
1999
42
Contributions of polyol pathway to oxidative stress in diabetic cataract. (9872926)
1999
43
The effects of simulated cataract on reading with normal vision and simulated central scotoma. (10755163)
1999
44
A prospective randomized comparison of two techniques of combined cataract-glaucoma surgery. (10541897)
1999
45
Clear corneal cataract surgery in ocular cicatricial pemphigoid. (9100121)
1997
46
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)
1990
47
The Emory mouse cataract: an animal model for human senile cataract. (7346236)
1981-1982
48
Senile cataract and plasma tryptophan. (6115288)
1981
49
Model reproduction of diabetic cataract in vitro. (5786891)
1969
50
Retinal detachments occurring in cataract associated with neurodermatitis. (14932558)
1952

Variations for Cataract

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Expression for genes affiliated with Cataract

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Search GEO for disease gene expression data for Cataract.

Pathways for genes affiliated with Cataract

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Compounds for genes affiliated with Cataract

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Compounds related to Cataract according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gap 276110.2GJA8, GJA3
2carbenoxolone disodium6110.2GJA8, GJA3
3scrambled 10panx6110.1GJA8, GJA3
410panx6110.1GJA8, GJA3
5octanol30 2611.0GJA3, GJA8
6flufenamic acid30 45 3 1313.0GJA3, GJA8
7mp 264510.0GJA3, CRYAA, LIM2
8carbenoxolone45 30 1311.9GJA8, GJA3
9ca2+309.7GJA3, GJA8

GO Terms for genes affiliated with Cataract

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Cellular components related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:000592210.0GJA3, GJA8

Biological processes related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lens fiber cell differentiationGO:007030610.0MAF, CRYGD
2camera-type eye developmentGO:00430109.7CRYGC, HSF4
3lens fiber cell morphogenesisGO:00703099.6CRYAA, CRYGB, EPHA2
4cell developmentGO:00484689.5MAF, HSF4
5lens development in camera-type eyeGO:00020889.3LIM2, CRYGS, CRYGD, CRYBA1, GJA8
6visual perceptionGO:00076018.0GJA3, CRYGD, CRYGB, CRYBB3, CRYBA1, CRYAA

Molecular functions related to Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of eye lensGO:00052128.0CRYGC, CRYAA, CRYBA1, CRYBB3, CRYGB, CRYGD

Products for genes affiliated with Cataract

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Sources for Cataract

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet