MCID: CTR002
MIFTS: 57

Cataract

Categories: Eye diseases, Rare diseases, Genetic diseases, Fetal diseases, Neuronal diseases

Aliases & Classifications for Cataract

MalaCards integrated aliases for Cataract:

Name: Cataract 38 12 29 29 52 41 42 14

Classifications:



External Ids:

Disease Ontology 12 DOID:83
ICD10 33 H26
ICD9CM 35 366.8
MeSH 42 D002386
SNOMED-CT 64 193620000 193622008
UMLS 69 C0029531

Summaries for Cataract

MedlinePlus : 41 a cataract is a clouding of the lens in your eye. it affects your vision. cataracts are very common in older people. by age 80, more than half of all americans either have a cataract or have had cataract surgery. a cataract can occur in either or both eyes. it cannot spread from one eye to the other. common symptoms are blurry vision colors that seem faded glare - headlights, lamps or sunlight may seem too bright. you may also see a halo around lights. not being able to see well at night double vision frequent prescription changes in your eye wear cataracts usually develop slowly. new glasses, brighter lighting, anti-glare sunglasses or magnifying lenses can help at first. surgery is also an option. it involves removing the cloudy lens and replacing it with an artificial lens. wearing sunglasses and a hat with a brim to block ultraviolet sunlight may help to delay cataracts. nih: national eye institute

MalaCards based summary : Cataract is related to cataract 1, multiple types and cataract 11, multiple types. An important gene associated with Cataract is IARS2 (Isoleucyl-TRNA Synthetase 2, Mitochondrial). The drugs Gabapentin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include Eye, eye and endothelial, and related phenotype is vision/eye.

Disease Ontology : 12 A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.

Wikipedia : 72 A cataract is a clouding of the lens in the eye which leads to a decrease in vision. Cataracts often... more...

Related Diseases for Cataract

Diseases in the Cataract family:

Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 39, Multiple Types, Autosomal Dominant Cataract 2, Multiple Types
Cataract 4, Multiple Types Cataract 42
Cataract 18, Autosomal Recessive Cataract 12, Multiple Types
Cataract 20, Multiple Types Cataract 41
Cataract 46, Juvenile-Onset Cataract 38, Autosomal Recessive
Cataract 26, Multiple Types Cataract 36
Cataract 11, Multiple Types Cataract 16, Multiple Types
Cataract 15, Multiple Types Cataract 14, Multiple Types
Cataract 32, Multiple Types Cataract 25
Cataract 5, Multiple Types Cataract 21, Multiple Types
Cataract 43 Cataract 10, Multiple Types
Cataract 7 Cataract 45
Cataract 19, Multiple Types Cataract 33, Multiple Types
Cataract 31, Multiple Types Cataract 9, Multiple Types
Cataract 44 Cataract 17, Multiple Types
Cataract 3, Multiple Types Cataract 22
Cataract 23 Cataract 28
Cataract 37 Cataract 35
Cataract 33 Cataract Congenital Autosomal Dominant
Cataract, Total Congenital Cataract 19
Cataract, Autosomal Dominant Congenital 4 Cataracts, Autosomal Recessive
Foxe3-Related Cataracts, Autosomal Dominant

Diseases related to Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 737)
id Related Disease Score Top Affiliating Genes
1 cataract 1, multiple types 34.1 GJA3 GJA8
2 cataract 11, multiple types 33.8 CRYGS PITX3
3 cataract, total congenital 32.1 CRYAA CRYBA4 CRYBB1 CRYGC CRYGD GJA8
4 down syndrome 27.7 CRYAA CRYAB CRYBA1 CRYBB1 CRYBB3 CRYGC
5 hyperferritinemia-cataract syndrome 12.2
6 cataract 21, multiple types 12.1
7 cataract 9, multiple types 12.1
8 cataract 4, multiple types 12.1
9 cataract 3, multiple types 12.1
10 cataract 6, multiple types 12.1
11 cataract 2, multiple types 12.1
12 cataract 16, multiple types 12.1
13 cerulean cataract 12.1
14 cataract 10, multiple types 12.1
15 cataract 17, multiple types 12.1
16 cataract 22 12.1
17 cataract 30, pulverulent 12.1
18 cataract 31, multiple types 12.1
19 cataract 18, autosomal recessive 12.1
20 cataract 14, multiple types 12.1
21 cataract 23 12.1
22 cataract 5, multiple types 12.0
23 congenital cataracts, facial dysmorphism, and neuropathy 12.0
24 cataract 40, x-linked 12.0
25 cataract 41 12.0
26 cataract microcornea syndrome 12.0
27 cataract 34, multiple types 12.0
28 cataract 7 12.0
29 cataract 39, multiple types, autosomal dominant 12.0
30 cataract 24, anterior polar 12.0
31 cataract 8, multiple types 12.0
32 cataract 38, autosomal recessive 12.0
33 cataract 46, juvenile-onset 12.0
34 cataract 19, multiple types 12.0
35 cataract 26, multiple types 12.0
36 cataract 13 with adult i phenotype 12.0
37 cataract 12, multiple types 12.0
38 cataract 20, multiple types 12.0
39 cataract 44 12.0
40 cataract 25 12.0
41 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 12.0
42 cataract 15, multiple types 11.9
43 cataract 32, multiple types 11.9
44 cataract 29, coralliform 11.9
45 cataract 47, juvenile, with microcornea 11.9
46 cataract 43 11.9
47 cataract 45 11.9
48 senile cataract 11.9
49 3-methylglutaconic aciduria, type vii, with cataracts, neurologic involvement and neutropenia 11.9
50 congenital cataracts, hearing loss, and neurodegeneration 11.9

Graphical network of the top 20 diseases related to Cataract:



Diseases related to Cataract

Symptoms & Phenotypes for Cataract

MGI Mouse Phenotypes related to Cataract:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.47 EPHA2 GJA3 GJA8 HSF4 LIM2 MAF

Drugs & Therapeutics for Cataract

Drugs for Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 399)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4,Phase 1,Phase 2 60142-96-3 3446
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
3
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved Phase 4,Phase 3,Phase 2,Phase 1 35189-28-7 6540478
6
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
7
Loteprednol Approved Phase 4,Phase 3 82034-46-6, 129260-79-3 444025 9865442
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
10
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
11
Nepafenac Approved Phase 4,Phase 3,Phase 2 78281-72-8 151075
12
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1 9004-61-9 53477741 24759
13
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
15
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2 32986-56-4 5496 36294
16
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
17
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
18
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
19
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
20
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
21
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
22
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
23
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
24
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 216974-75-3
25
Oxymetazoline Approved Phase 4,Phase 3 1491-59-4 4636
26
Phenylephrine Approved Phase 4,Phase 3 59-42-7 6041
27
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
28
Dalteparin Approved Phase 4 9005-49-6
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
31
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
32
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
33
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
34
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
35 Homatropine Approved Phase 4 87-00-3
36
Dinoprostone Approved Phase 4 363-24-6 5280360
37
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
38 Racepinephrine Approved Phase 4,Phase 2
39
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
40
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
41
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
42
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
43
Gatifloxacin Approved, Investigational Phase 4,Phase 1 112811-59-3 5379
44
Vancomycin Approved Phase 4,Phase 3 1404-90-6 441141 14969
45
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
46
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2 155206-00-1 5311027
47
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Phase 2 85721-33-1 2764
48
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
49
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
50
Ethanol Approved Phase 4 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 1030)

id Name Status NCT ID Phase Drugs
1 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
2 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
3 A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. Unknown status NCT00326066 Phase 4
4 Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery Unknown status NCT01455467 Phase 4
5 Effect of Gabapentin on Pain of the Second Cataract Surgery Unknown status NCT02127853 Phase 4 gabapentin;placebo
6 A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery Unknown status NCT01296542 Phase 4
7 Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens Unknown status NCT01615861 Phase 4
8 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
9 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4 Moxifloxacin;besifloxacin
10 Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification Unknown status NCT01193504 Phase 4 Pred Forte;Lotemax
11 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
12 Efficacy of Subtenon's Block With Olive Tipped Cannula Unknown status NCT01019018 Phase 4
13 Clinical Investigation of the Modified Rayner Monofocal Aspheric 600C (With Axis Marks) Intraocular Lens Unknown status NCT02378636 Phase 4
14 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
15 Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies Unknown status NCT00865540 Phase 4 prednisolone acetate 1%;ketorolac tromethamine 0.4%;nepafenac 0.1%;methylcellulose 0.5%
16 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
17 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
18 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
19 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
20 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
21 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
22 IntraVitreal Triamcinolone Acetonide: Preventing Raised Eye-pressure by Tracking Elevations After Topical Steroids Unknown status NCT00744666 Phase 4 Prednisolone 1% topical eye drops
23 Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema Unknown status NCT02399657 Phase 4 Intravitreal dexamethasone 0.7mg implant
24 Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery Completed NCT02023437 Phase 4
25 Aphakia Versus Pseudophakia in Children Under 2 Years Undergoing Bilateral Congenital Cataract Surgery Completed NCT01297153 Phase 4
26 A Single Centre Study to Analyze Cataract Surgery Following Femtosecond Laser-Assisted and Manual Cataract Surgery Completed NCT01769313 Phase 4
27 Size Progression of Macular Degeneration After Cataract Surgery Completed NCT01165801 Phase 4
28 To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery. Completed NCT00763360 Phase 4 Healon;Amvisc Plus
29 Clinical Trial on Anti-inflammatory Effect of Low-Molecular Weight Heparin in Pediatric Cataract Surgery Completed NCT00986076 Phase 4 Enoxaparin;Balanced Salt Solution
30 Dexmedetomidine vs. Propofol for Cataract Surgery Completed NCT00786370 Phase 4 dexmedetomidine;Propofol;Dexemedetomidine
31 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
32 Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism Completed NCT01763151 Phase 4
33 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed NCT00870103 Phase 4 Vigadexa (moxifloxacin 0.5% and dexamethasone 0.1%) eye drops
34 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed NCT01261975 Phase 4
35 2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery Completed NCT01455233 Phase 4 besivance;vigamox
36 Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery Completed NCT00575380 Phase 4 AzaSite Eye Drops;Vigamox Eye Drops
37 Comparing Optical Coherence Tomography (OCT) and Visual Acuity Outcomes in Subjects Undergoing Cataract Surgery, Who Receive Xibrom Ophthalmic Solution and Standard Presurgical Care vs. Xibrom Ophthalmic Solution Plus Prednisolone Acetate 1% and Standard Completed NCT00698724 Phase 4 Xibrom, and Optive;Xibrom and Pred Forte
38 Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema Completed NCT01546402 Phase 4 Dexamethasone Drug delivery system (Ozurdex)
39 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
40 Laser Cataract Surgery With the Femtosecond Laser Technology Completed NCT01382823 Phase 4
41 Dispervise Ophthalmic Viscoelastic as an Agent to Ensure Watertight Wound Closure After Clear Corneal Cataract Incisions Completed NCT01298973 Phase 4 Viscoat;Saline
42 Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery Completed NCT01542190 Phase 4 Ketorolac Tromethamine
43 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
44 Determination of Optimum Duration of Treatment With Bromfenac (Xibrom) Eyedrops Following Cataract Surgery Completed NCT00758199 Phase 4 Bromfenac;Moxifloxacin hydrochloride;Prednisolone Acetate
45 Influence of Two Different Preloaded Intraocular Lens (IOLs) on Posterior Capsule Opacification Completed NCT00673803 Phase 4
46 Clear Corneal Incisions and Arcuate Incisions Utilizing FemtoSecond Laser Technology for Cataract Surgery Completed NCT01383057 Phase 4
47 Acular LS vs. Nevanac in Post op Inflammation Following Cataract Surgery Completed NCT00348582 Phase 4 Ketorolac, Nepafenac
48 Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs Completed NCT00366587 Phase 4
49 Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients Completed NCT01859702 Phase 4 Moxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution
50 Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects Completed NCT00469690 Phase 4 Acular, Xibrom

Search NIH Clinical Center for Cataract

Cochrane evidence based reviews: cataract

Genetic Tests for Cataract

Genetic tests related to Cataract:

id Genetic test Affiliating Genes
1 Cataract 29

Anatomical Context for Cataract

MalaCards organs/tissues related to Cataract:

39
Eye, Endothelial, Testes, Bone, Liver, Kidney, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Cataract:
id Tissue Anatomical CompartmentCell Relevance
1 Eye Lens Affected by disease

Publications for Cataract

Articles related to Cataract:

(show top 50) (show all 2931)
id Title Authors Year
1
Cataract Surgery in Patients with Keratoconus: Pearls and Pitfalls. ( 28932335 )
2017
2
Novel PEX11B Mutations Extend the Peroxisome Biogenesis Disorder 14B Phenotypic Spectrum and Underscore Congenital Cataract as an Early Feature. ( 28129423 )
2017
3
The Use of Cataract Scalpel Blade for Shave Biopsy in the Nail Matrix. ( 28930793 )
2017
4
Re: Javitt JC: Intracameral antibiotics reduce the risk of endophthalmitis after cataract surgery: does the preponderance of the evidence mandate a global change in practice? (Ophthalmology 2016;123:226-231). ( 27993282 )
2017
5
A novel frameshift mutation in the sterol 27-hydroxylase gene in an Egyptian family with cerebrotendinous xanthomatosis without cataract. ( 28229379 )
2017
6
Rates of Routine Cataract Surgery Among Medicare Beneficiaries. ( 28056119 )
2017
7
Long-term results of cataract surgery in patients with anterior uveitis. ( 28602016 )
2017
8
Different-sized incisions for phacoemulsification in age-related cataract. ( 28931202 )
2017
9
Targeted exome sequencing of congenital cataracts related genes: broadening the mutation spectrum and genotype-phenotype correlations in 27 Chinese Han families. ( 28450710 )
2017
10
Effects of intracameral cefuroxime on corneal endothelial cell counts and its morphology after cataract surgery. ( 28932504 )
2017
11
Incidence, Risk Factors, and Outcomes of Retinal Detachment after Pediatric Cataract Surgery. ( 28844322 )
2017
12
Combined Phacoemulsification and Intravitreal Dexamethasone Implant (OzurdexAr) in Diabetic Patients with Coexisting Cataract and Diabetic Macular Edema. ( 28884024 )
2017
13
Family-based whole exome sequencing of atopic dermatitis complicated with cataracts. ( 28938649 )
2017
14
Effectiveness and safety of combined cataract surgery and microhook ab interno trabeculotomy in Japanese eyes with glaucoma: report of an initial case series. ( 28929279 )
2017
15
Gathering cataract surgery outcome measures in a busy clinical practice. ( 28951176 )
2017
16
Down-regulation of GJA3 is associated with lens epithelial cell apoptosis and age-related cataract. ( 28088522 )
2017
17
INPP5K variant causes autosomal recessive congenital cataract in a Pakistani family. ( 28940338 )
2017
18
Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis. ( 27840165 )
2017
19
A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. ( 28132692 )
2017
20
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
21
Survival analysis of visual improvement after cataract surgery in advanced retinitis pigmentosa. ( 28776592 )
2017
22
Surgical treatment and visual outcomes of cataract with persistent hyperplastic primary vitreous. ( 28393030 )
2017
23
Hallermann-Streiff syndrome with bilateral microphthalmia, pupillary membranes and cataract absorption. ( 28730099 )
2017
24
Interaction of AR and iNOS in lens epithelial cell: A new pathogenesis and potential therapeutic targets of diabetic cataract. ( 28108234 )
2017
25
Comparison of the mechanical properties of the anterior lens capsule in senile cataract, senile cataract with trypan blue application, and pseudoexfoliation syndrome. ( 28917406 )
2017
26
Preoperative Expectations and Postoperative Outcomes of Visual Functioning among Cataract Patients in Urban Southern China. ( 28068402 )
2017
27
Identification of a Novel Mutation in BRD4 that Causes Autosomal Dominant Syndromic Congenital Cataracts Associated with Other Neuro-Skeletal Anomalies. ( 28076398 )
2017
28
A 16.7A kb deletion in Sipa1l3 is associated with juvenile cataract in mice. ( 28951961 )
2017
29
Association of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract. ( 28298860 )
2017
30
Does oxidative stress play any role in diabetic cataract formation? ----Re-evaluation using a thioltransferase gene knockout mouse model. ( 28579033 )
2017
31
Effects of adjuvant omega-3 fatty acid supplementation on dry eye syndrome following cataract surgery: A randomized clinical trial. ( 28367524 )
2017
32
Re: Javitt JC: Intracameral antibiotics reduce the risk of endophthalmitis after cataract surgery: does the preponderance of the evidence mandate a global change in practice? (Ophthalmology 2016;123:226-231). ( 27993280 )
2017
33
Aqueous misdirection masked as myopia after cataract surgery. ( 28774542 )
2017
34
Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract. ( 28942547 )
2017
35
Pinus densiflora bark extract prevents selenite-induced cataract formation in the lens of Sprague Dawley rat pups. ( 28943754 )
2017
36
Non-invasive tryptophan fluorescence measurements as a novel method of grading cataract. ( 28935513 )
2017
37
Challenges with cataract surgery in pars planitis patients. ( 28593425 )
2017
38
Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis. ( 28253266 )
2017
39
Re: Jabbarvand etA al.: Endophthalmitis occurring after cataract surgery: outcomes of more than 480 000 cataract surgeries, epidemiologic features, and risk factors (Ophthalmology 2016;123:295-301). ( 27993276 )
2017
40
Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression. ( 28065730 )
2017
41
Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans. ( 28837160 )
2017
42
Bioinformatics Study of m.9053G>A Mutation at the ATP6 Gene in Relation to Type 2 Diabetes Mellitus and Cataract Diseases. ( 28932107 )
2017
43
Cataract surgery in patients with late-onset retinal degeneration. ( 28917403 )
2017
44
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 28192644 )
2017
45
Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts. ( 28468959 )
2017
46
Predictive factors of visual outcome of Malaysian cataract patients: a retrospective study. ( 28944207 )
2017
47
Podoconiosis, trachomatous trichiasis and cataract in northern Ethiopia: A comparative cross sectional study. ( 28187129 )
2017
48
Change of Capsulotomy Over 1 Year in Femtosecond Laser-Assisted Cataract Surgery and Its Impact on Visual Quality. ( 28068446 )
2017
49
Investigation of the molecular mechanisms underlying myotonic dystrophy types 1 and 2 cataracts using microRNAa89target gene networks. ( 28731161 )
2017
50
Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment. ( 28190456 )
2017

Variations for Cataract

ClinVar genetic disease variations for Cataract:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Cataract from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 86882 14 67000000 106368585 Copy number cataract
2 89231 15 17000000 100338915 Copy number cataract
3 106728 17 1 11200000 Copy number cataract

Expression for Cataract

Search GEO for disease gene expression data for Cataract.

Pathways for Cataract

GO Terms for Cataract

Cellular components related to Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJA3 GJA8
2 connexin complex GO:0005922 8.62 GJA3 GJA8

Biological processes related to Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.67 CRYAA CRYAB GJA8 HSF4
2 visual perception GO:0007601 9.65 CRYAA CRYBA1 CRYBA4 CRYBB1 CRYBB3 CRYGC
3 camera-type eye development GO:0043010 9.46 CRYBA4 GJA8 HSF4 LIM2
4 lens fiber cell differentiation GO:0070306 9.43 CRYGD MAF PITX3
5 negative regulation of cytokine production GO:0001818 9.4 CRYBA1 EPHA2
6 negative regulation of intracellular transport GO:0032387 9.32 CRYAA CRYAB
7 lens development in camera-type eye GO:0002088 9.28 CRYAB CRYBA1 CRYGD CRYGS GJA8 LIM2

Molecular functions related to Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.36 BFSP1 CRYAA CRYAB CRYBA1 CRYBA4 CRYBB1
2 gap junction channel activity GO:0005243 8.96 GJA3 GJA8

Sources for Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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