CCSSO
MCID: CTR121
MIFTS: 33

Cataract 25 (CCSSO) malady

Categories: Eye diseases, Fetal diseases, Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Cataract 25

Aliases & Descriptions for Cataract 25:

Name: Cataract 25 54 12
Early-Onset Cataract with Y-Shaped Suture Opacities 12 56
Cataract, Central Saccular, with Sutural Opacities 13 69
Central Pouch-Like Cataract with Sutural Opacities 12
Central Saccular Cataract with Sutural Opacities 12
Early-Onset Sutural Cataract 56
Ctrct25 12
Ccsso 12

Characteristics:

Orphanet epidemiological data:

56
early-onset sutural cataract
Inheritance: Autosomal dominant; Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

OMIM 54 605728
Disease Ontology 12 DOID:0110254
ICD10 33 Q12.0
Orphanet 56 ORPHA98985
ICD10 via Orphanet 34 Q12.0

Summaries for Cataract 25

Disease Ontology : 12 A cataract that has material basis in variation in the region 15q21-q22.

MalaCards based summary : Cataract 25, also known as early-onset cataract with y-shaped suture opacities, is related to charcot-marie-tooth disease type 2k and caudal appendage deafness. An important gene associated with Cataract 25 is CRYBB2 (Crystallin Beta B2). The drugs Dipivefrin and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is vision/eye.

Description from OMIM: 605728

Related Diseases for Cataract 25

Diseases in the Cataract family:

Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 39, Multiple Types, Autosomal Dominant Cataract 2, Multiple Types
Cataract 4, Multiple Types Cataract 42
Cataract 18, Autosomal Recessive Cataract 20, Multiple Types
Cataract 41 Cataract 38, Autosomal Recessive
Cataract 26, Multiple Types Cataract 36
Cataract 11, Multiple Types Cataract 16, Multiple Types
Cataract 15, Multiple Types Cataract 14, Multiple Types
Cataract 32, Multiple Types Cataract 25
Cataract 5, Multiple Types Cataract 21, Multiple Types
Cataract 43 Cataract 10, Multiple Types
Cataract 7 Cataract 19
Cataract 33 Cataract 31, Multiple Types
Cataract 9, Multiple Types Cataract 44
Cataract 17, Multiple Types Cataract 3, Multiple Types
Cataract 22, Autosomal Recessive Cataract 23
Cataract 46 Juvenile-Onset Cataract 28
Cataract 37 Cataract 35
Cataract 45 Cataract 19 Multiple Types
Cataract Congenital Autosomal Dominant Cataract, Total Congenital
Cataract 47 Cataract, Autosomal Dominant Congenital 4
Cataracts, Autosomal Recessive Foxe3-Related Cataracts, Autosomal Dominant

Diseases related to Cataract 25 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease type 2k 9.9 CRYBB2 MIP
2 caudal appendage deafness 9.9 CRYBB2 GJA8
3 palindromic rheumatism 9.9 BFSP2 MIP
4 combined sap deficiency 9.9 BFSP2 CRYBB2 GJA8
5 malignant eyelid melanoma 9.9 BFSP2 MIP
6 leukocyte adhesion deficiency 9.9 CRYBB2 GJA8
7 pseudopterygium 9.8 CRYGS MIP
8 endometrial stromal nodule 9.8 CRYBB2 CRYGS MIP
9 popliteal pterygium syndrome 2, lethal type 9.7 CRYBB2 GJA8 MIP
10 cardiomyopathy, dilated, 1ii 9.6 BFSP2 CRYBA1 CRYGS MIP
11 tunnel subaortic stenosis 9.6 CRYBA1 CRYBB2 GJA8 MIP
12 cervical squamous cell carcinoma 9.2 BFSP2 CRYBA1 CRYBB2 CRYGS GJA8 MIP
13 osteogenesis imperfecta, type ix 9.0 BFSP2 CRYBA1 CRYBB2 CRYGS CTRCT25 GJA8

Graphical network of the top 20 diseases related to Cataract 25:



Diseases related to Cataract 25

Symptoms & Phenotypes for Cataract 25

Clinical features from OMIM:

605728

MGI Mouse Phenotypes related to Cataract 25:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.1 GJA8 MIP BFSP2 CRYBA1 CRYBB2 CRYGS

Drugs & Therapeutics for Cataract 25

Drugs for Cataract 25 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4 52365-63-6 3105
2
Azathioprine Approved Phase 4 446-86-6 2265
3
Chlorambucil Approved Phase 4 305-03-3 2708
4
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
5
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
6
Daclizumab Approved, Investigational Phase 4 152923-56-3
7
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
8
Infliximab Approved Phase 4 170277-31-3
9
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
10
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
11
Mycophenolic acid Approved Phase 4 24280-93-1 446541
12
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
13
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
14
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
15 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
16 Antirheumatic Agents Phase 4
17 Pharmaceutical Solutions Phase 4
18 Alkylating Agents Phase 4
19 Antimetabolites Phase 4,Phase 3
20 Antimetabolites, Antineoplastic Phase 4
21 Antineoplastic Agents, Alkylating Phase 4
22 glucocorticoids Phase 4,Phase 1,Phase 2
23 Hormone Antagonists Phase 4,Phase 1,Phase 2
24 Hormones Phase 4,Phase 1,Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1,Phase 2
26 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
27 Anesthetics Phase 4
28 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
29 Hypnotics and Sedatives Phase 4
30 Anesthetics, General Phase 4
31 Anesthetics, Intravenous Phase 4
32 Fat Emulsions, Intravenous Phase 4
33 Parenteral Nutrition Solutions Phase 4
34 Soybean oil, phospholipid emulsion Phase 4
35 Soy Bean Nutraceutical Phase 4
36
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
37
Peginterferon alfa-2a Approved, Investigational Phase 3 198153-51-4 5360545
38
Ribavirin Approved Phase 3 36791-04-5 37542
39
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
40 tannic acid Approved, Nutraceutical Phase 3
41 Anti-Infective Agents Phase 3,Phase 1,Phase 2
42 Antiviral Agents Phase 3
43 interferons Phase 3
44 Liver Extracts Phase 3
45
Gabapentin Approved, Investigational Phase 1, Phase 2 60142-96-3 3446
46
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
47
Ciprofloxacin Approved, Investigational Phase 1, Phase 2 85721-33-1 2764
48
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
49
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
50
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896

Interventional clinical trials:

(show all 50)
id Name Status NCT ID Phase
1 Visual Acuity After the Combined Binocular Implantation of +2.5 Diopters and +3.0 Diopters ReSTOR Multifocal Intraocular Lenses. Completed NCT02314572 Phase 4
2 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
3 Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs Completed NCT00366587 Phase 4
4 Comparison of the Quality of Vision Provided by AMO Tecnis Z9000 and Alcon Laboratories MA60 Acrysof Posterior Chamber Intraocular Lenses Completed NCT00348270 Phase 4
5 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
6 CME With Different Fluidic Parameters Completed NCT01385852 Phase 4
7 Prospective Evaluation of Visual Outcomes With Tecnis One-Piece Multifocal Intraocular Lenses Compared With Patients Previously Implanted With Crystalens Aspheric Optic (AO) Completed NCT01191229 Phase 4
8 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4
9 Clinical Outcomes After Bilateral Implantation of ZEISS AT LISA TRI TORIC IOL Recruiting NCT02770924 Phase 4
10 Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia Recruiting NCT02771912 Phase 4
11 Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Subjects With Hepatitis C Related Liver Disease Completed NCT00516321 Phase 3
12 Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Benefit Subjects With Hepatitis C Liver Disease Completed NCT00529568 Phase 3
13 Evaluation of Anxiolysis and Pain Associated With Retrobulbar Eye Block for Cataract Surgery : Melatonin Versus Gabapentin Completed NCT01200641 Phase 1, Phase 2
14 Use of Immune Globulin Intravenous (Human) To Treat Age-Related Macular Degeneration Completed NCT00220805 Phase 2
15 Sub-Tenon's Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery Terminated NCT00431028 Phase 1, Phase 2
16 Hydrophilic Acrylic Intraocular Lens Unknown status NCT00708331
17 Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Unknown status NCT01847638
18 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252
19 Triple Therapy for Diffuse Diabetic Macular Edema Unknown status NCT01218750
20 Evaluate Capsular Apposition to Intraocular Lens Unknown status NCT01605812
21 AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0] in Japan Completed NCT01605877
22 Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes Completed NCT01771939
23 Comparative Study of Three IOL Power Calculation Formulae for Asian Eyes Shorter Than 22mm or Longer Than 25mm Completed NCT00347516
24 Clinical Investigation of AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0] Completed NCT01510717
25 A Clinical Outcome Study of Two Multifocal Intraocular Lenses (IOL) in Cataract Patients Completed NCT01684007
26 Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surgery Completed NCT02073266
27 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
28 Comparison of Scheimpflug Photos of the Crystalline Lens in Patients Who Have Undergone Vitrectomy Surgery and Controls Completed NCT00406263
29 Wavefront Analysis and Contrast Sensitivity After Cataract Surgery With Akreos Advanced Optics Intraocular Lens Implantation Completed NCT00863759
30 Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery Completed NCT01334658
31 Multifocal Intraocular Lens x Monovision x Hybrid Monovision After Bilateral Cataract Surgery Completed NCT02595177
32 Set up for in-Vivo Measurement of Dynamic Intraocular Pressure (IOP) Completed NCT00856141
33 A Real-World Registry to Investigate the Performance of LenSx® Laser in Chinese Patients Completed NCT02396719
34 Serum and Intraocular Levels of Erythropoietin and VEGF in Type 2 Diabetes Patients With Proliferative Retinopathy Completed NCT01871207
35 Elongation of Foveal Tissue After Macular Hole Surgery Completed NCT01471912
36 Combined 25-gauge Vitrectomy and Cataract Surgery With Toric Intraocular Lens With Idiopathic Epiretinal Membrane. Recruiting NCT02328157
37 Assessment of Visual Performance Combining a Symfony IOL and a +3.25 Tecnis Multifocal IOL Recruiting NCT02847572
38 Symfony Toric Intraocular Lens Visual Outcomes Recruiting NCT03082599
39 Microincision Versus Smallincision Combined Surgery Recruiting NCT01198483
40 Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes Recruiting NCT03152747
41 Prospective, Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane (ILM) Peeling During Epimacular Membrane (EMM) Surgery (Peeling) Recruiting NCT02146144
42 Repeatability and Concordance of VA Measured With ETDRS Numeric , Landolt C, and Letter Charts in Thai Individuals Recruiting NCT02810665
43 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
44 Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal Recruiting NCT01532765
45 A Trial of China Laser and Surgery Study Glaucoma in Rural China Active, not recruiting NCT02955849 Early Phase 1
46 An Epidemiologic Study of Disease Progression in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration (Proxima A). Active, not recruiting NCT02479386
47 Assessing Ocular Hemodynamic Response to Surgical Intervention in Glaucoma Not yet recruiting NCT02891317
48 Efficacy of Ozurdex® in the Treatment of Diabetic Macular Edema (DME) Not yet recruiting NCT03003416
49 Multifocals and Accommodating/Bilateral Implantation of Different Multifocal Intraocular Lens (IOLs) Terminated NCT00934960
50 Retrobulbar Injection of Anesthesia Versus Healon 5 in the Management of Intraoperative Floppy Iris Syndrome Terminated NCT00627913

Search NIH Clinical Center for Cataract 25

Genetic Tests for Cataract 25

Anatomical Context for Cataract 25

MalaCards organs/tissues related to Cataract 25:

39
Eye

Publications for Cataract 25

Variations for Cataract 25

Expression for Cataract 25

Search GEO for disease gene expression data for Cataract 25.

Pathways for Cataract 25

GO Terms for Cataract 25

Cellular components related to Cataract 25 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.62 GJA8 MIP

Biological processes related to Cataract 25 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.43 BFSP2 CRYBB2 MIP
2 visual perception GO:0007601 9.35 BFSP2 CRYBA1 CRYBB2 GJA8 MIP
3 camera-type eye development GO:0043010 9.16 CRYBB2 GJA8
4 lens development in camera-type eye GO:0002088 8.92 CRYBA1 CRYGS GJA8 MIP

Molecular functions related to Cataract 25 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.02 BFSP2 CRYBA1 CRYBB2 CRYGS MIP

Sources for Cataract 25

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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