MCID: CTR121
MIFTS: 33

Cataract 25

Categories: Eye diseases, Fetal diseases, Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Cataract 25

MalaCards integrated aliases for Cataract 25:

Name: Cataract 25 54 12
Early-Onset Cataract with Y-Shaped Suture Opacities 12 56
Cataract, Central Saccular, with Sutural Opacities 13 69
Central Pouch-Like Cataract with Sutural Opacities 12
Central Saccular Cataract with Sutural Opacities 12
Early-Onset Sutural Cataract 56
Ctrct25 12
Ccsso 12

Characteristics:

Orphanet epidemiological data:

56
early-onset sutural cataract
Inheritance: Autosomal dominant; Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

OMIM 54 605728
Disease Ontology 12 DOID:0110254
ICD10 33 Q12.0
Orphanet 56 ORPHA98985
UMLS via Orphanet 70 C1854021
ICD10 via Orphanet 34 Q12.0

Summaries for Cataract 25

Disease Ontology : 12 A cataract that has material basis in variation in the region 15q21-q22.

MalaCards based summary : Cataract 25, also known as early-onset cataract with y-shaped suture opacities, is related to cataract, total congenital and palindromic rheumatism. An important gene associated with Cataract 25 is GJA8 (Gap Junction Protein Alpha 8). The drugs Dipivefrin and Propofol have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotype is vision/eye.

Description from OMIM: 605728

Related Diseases for Cataract 25

Diseases in the Cataract family:

Cataract 8, Multiple Types Cataract 6, Multiple Types
Cataract 34, Multiple Types Cataract 1, Multiple Types
Cataract 39, Multiple Types, Autosomal Dominant Cataract 2, Multiple Types
Cataract 4, Multiple Types Cataract 42
Cataract 18, Autosomal Recessive Cataract 12, Multiple Types
Cataract 20, Multiple Types Cataract 41
Cataract 46, Juvenile-Onset Cataract 38, Autosomal Recessive
Cataract 26, Multiple Types Cataract 36
Cataract 11, Multiple Types Cataract 16, Multiple Types
Cataract 15, Multiple Types Cataract 14, Multiple Types
Cataract 32, Multiple Types Cataract 25
Cataract 5, Multiple Types Cataract 21, Multiple Types
Cataract 43 Cataract 10, Multiple Types
Cataract 7 Cataract 45
Cataract 19, Multiple Types Cataract 33, Multiple Types
Cataract 31, Multiple Types Cataract 9, Multiple Types
Cataract 44 Cataract 17, Multiple Types
Cataract 3, Multiple Types Cataract 22
Cataract 23 Cataract 28
Cataract 37 Cataract 35
Cataract 33 Cataract Congenital Autosomal Dominant
Cataract, Total Congenital Cataract 19
Cataract, Autosomal Dominant Congenital 4 Cataracts, Autosomal Recessive
Foxe3-Related Cataracts, Autosomal Dominant

Diseases related to Cataract 25 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 cataract, total congenital 9.9 CRYBB2 GJA8
2 palindromic rheumatism 9.5 BFSP2 CRYGS MIP
3 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 9.5 CRYBB2 MIP
4 pancreatic and cerebellar agenesis 9.5 BFSP2 CRYBB2 GJA8
5 late congenital syphilis 9.5 BFSP2 CRYGS MIP
6 endometrial stromal nodule 9.4 CRYBB2 CRYGS MIP
7 popliteal pterygium syndrome, bartsocas-papas type 9.3 CRYBB2 GJA8 MIP
8 anorectal stricture 9.1 CRYBB2 CRYGS GJA8 MIP
9 double outlet right ventricle with subaortic or doubly committed ventricular septal defect with pulmonary stenosis 8.8 CRYBA1 CRYBB2 GJA8 MIP
10 myopathy, myofibrillar, fatal infantile hypertonic, alpha-b crystallin-related 8.8 BFSP2 CRYBA1 CRYGS MIP
11 down syndrome 7.9 BFSP2 CRYBA1 CRYBB2 CRYGS GJA8 MIP
12 cerebral palsy 7.9 BFSP2 CRYBA1 CRYBB2 CRYGS GJA8 MIP
13 gilles de la tourette syndrome 7.4 BFSP2 CRYBA1 CRYBB2 CRYGS CTRCT25 GJA8

Graphical network of the top 20 diseases related to Cataract 25:



Diseases related to Cataract 25

Symptoms & Phenotypes for Cataract 25

Clinical features from OMIM:

605728

MGI Mouse Phenotypes related to Cataract 25:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.1 BFSP2 CRYBA1 CRYBB2 CRYGS GJA8 MIP

Drugs & Therapeutics for Cataract 25

Drugs for Cataract 25 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4 52365-63-6 3105
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Pharmaceutical Solutions Phase 4
6 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
7 Anesthetics Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Intravenous Phase 4
10 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
11 Fat Emulsions, Intravenous Phase 4
12 Hypnotics and Sedatives Phase 4
13 Parenteral Nutrition Solutions Phase 4
14 Soybean oil, phospholipid emulsion Phase 4
15 Anesthetics, Local Phase 4
16 Anti-Arrhythmia Agents Phase 4
17
Atracurium Phase 4 64228-79-1 47319
18 Cholinergic Agents Phase 4
19 Cholinergic Antagonists Phase 4
20 Diuretics, Potassium Sparing Phase 4
21 Neuromuscular Agents Phase 4
22 Neuromuscular Blocking Agents Phase 4
23 Neuromuscular Nondepolarizing Agents Phase 4
24 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
25 Sodium Channel Blockers Phase 4
26 Soy Bean Nutraceutical Phase 4
27
Gabapentin Approved, Investigational Phase 1, Phase 2 60142-96-3 3446
28
Ciprofloxacin Approved, Investigational Phase 1, Phase 2 85721-33-1 2764
29
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
30
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
31
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
32
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
33
gamma-Aminobutyric acid Investigational Phase 1, Phase 2 56-12-2 119
34 Analgesics Phase 1, Phase 2
35 Anti-Inflammatory Agents Phase 1, Phase 2
36 Ophthalmic Solutions Phase 1, Phase 2
37 Anti-Anxiety Agents Phase 1, Phase 2
38 Anticonvulsants Phase 1, Phase 2
39 Antimanic Agents Phase 1, Phase 2
40 Antioxidants Phase 1, Phase 2
41 Antiparkinson Agents Phase 1, Phase 2
42 calcium channel blockers Phase 1, Phase 2
43 Calcium, Dietary Phase 1, Phase 2
44 Excitatory Amino Acid Antagonists Phase 1, Phase 2
45 Excitatory Amino Acids Phase 1, Phase 2
46 GABA Agents Phase 1, Phase 2
47 Protective Agents Phase 1, Phase 2
48 Psychotropic Drugs Phase 1, Phase 2
49 Tranquilizing Agents Phase 1, Phase 2
50 Antibodies Phase 2

Interventional clinical trials:

(show all 44)

id Name Status NCT ID Phase Drugs
1 Visual Acuity After the Combined Binocular Implantation of +2.5 Diopters and +3.0 Diopters ReSTOR Multifocal Intraocular Lenses. Completed NCT02314572 Phase 4
2 Clinical Outcomes After Bilateral Implantation of ZEISS AT LISA TRI AND TRI TORIC IOL Completed NCT02770924 Phase 4
3 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
4 Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs Completed NCT00366587 Phase 4
5 Comparison of the Quality of Vision Provided by AMO Tecnis Z9000 and Alcon Laboratories MA60 Acrysof Posterior Chamber Intraocular Lenses Completed NCT00348270 Phase 4
6 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
7 CME With Different Fluidic Parameters Completed NCT01385852 Phase 4
8 Prospective Evaluation of Visual Outcomes With Tecnis One-Piece Multifocal Intraocular Lenses Compared With Patients Previously Implanted With Crystalens Aspheric Optic (AO) Completed NCT01191229 Phase 4
9 Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia Completed NCT02771912 Phase 4 Propofol;Placebo
10 Efficacy and Safety of Adding Atracurium to Percaruncular Block for High Myopes Undergoing Cataract Surgery Completed NCT03243500 Phase 4 Atracurium;Lidocaine 2%;Bupivacaine 0.5%;hyaluronidase powder
11 Evaluation of Anxiolysis and Pain Associated With Retrobulbar Eye Block for Cataract Surgery : Melatonin Versus Gabapentin Completed NCT01200641 Phase 1, Phase 2 Melatonin;Gabapentin;placebo
12 Use of Immune Globulin Intravenous (Human) To Treat Age-Related Macular Degeneration Completed NCT00220805 Phase 2 Immune Globulin Intravenous [Human], 10% Caprylate/Chromatography Purified;Albumin (Human) 25%, United States Pharmacopeia (USP)
13 Sub-Tenon's Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery Terminated NCT00431028 Phase 1, Phase 2
14 Hydrophilic Acrylic Intraocular Lens Unknown status NCT00708331
15 Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Unknown status NCT01847638 Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
16 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
17 Triple Therapy for Diffuse Diabetic Macular Edema Unknown status NCT01218750
18 AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0] in Japan Completed NCT01605877
19 Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes Completed NCT01771939
20 Comparative Study of Three IOL Power Calculation Formulae for Asian Eyes Shorter Than 22mm or Longer Than 25mm Completed NCT00347516
21 Clinical Investigation of AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0] Completed NCT01510717
22 A Clinical Outcome Study of Two Multifocal Intraocular Lenses (IOL) in Cataract Patients Completed NCT01684007
23 Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surgery Completed NCT02073266
24 Retrospective / Prospective Clinical Study of AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric Intraocular Lenses Completed NCT02176343
25 Assessment of Visual Performance Combining a Symfony IOL and a +3.25 Tecnis Multifocal IOL Completed NCT02847572
26 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
27 Comparison of Scheimpflug Photos of the Crystalline Lens in Patients Who Have Undergone Vitrectomy Surgery and Controls Completed NCT00406263
28 Wavefront Analysis and Contrast Sensitivity After Cataract Surgery With Akreos Advanced Optics Intraocular Lens Implantation Completed NCT00863759
29 Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery Completed NCT01334658 Glucose-bicarbonate-Ringer Lactate (GBRL);Balanced Salt Solution (BSS®)
30 Multifocal Intraocular Lens x Monovision x Hybrid Monovision After Bilateral Cataract Surgery Completed NCT02595177
31 Set up for in-Vivo Measurement of Dynamic Intraocular Pressure (IOP) Completed NCT00856141
32 A Real-World Registry to Investigate the Performance of LenSx® Laser in Chinese Patients Completed NCT02396719
33 Serum and Intraocular Levels of Erythropoietin and VEGF in Type 2 Diabetes Patients With Proliferative Retinopathy Completed NCT01871207
34 Elongation of Foveal Tissue After Macular Hole Surgery Completed NCT01471912
35 Combined 25-gauge Vitrectomy and Cataract Surgery With Toric Intraocular Lens With Idiopathic Epiretinal Membrane. Recruiting NCT02328157
36 Symfony Toric Intraocular Lens Visual Outcomes Recruiting NCT03082599
37 Microincision Versus Smallincision Combined Surgery Recruiting NCT01198483
38 Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes Recruiting NCT03152747
39 Prospective, Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane (ILM) Peeling During Epimacular Membrane (EMM) Surgery (Peeling) Recruiting NCT02146144
40 Repeatability and Concordance of VA Measured With ETDRS Numeric , Landolt C, and Letter Charts in Thai Individuals Recruiting NCT02810665
41 A Trial of China Laser and Surgery Study Glaucoma in Rural China Active, not recruiting NCT02955849 Early Phase 1
42 Assessing Ocular Hemodynamic Response to Surgical Intervention in Glaucoma Not yet recruiting NCT02891317
43 Multifocals and Accommodating/Bilateral Implantation of Different Multifocal Intraocular Lens (IOLs) Terminated NCT00934960
44 Retrobulbar Injection of Anesthesia Versus Healon 5 in the Management of Intraoperative Floppy Iris Syndrome Terminated NCT00627913

Search NIH Clinical Center for Cataract 25

Genetic Tests for Cataract 25

Anatomical Context for Cataract 25

MalaCards organs/tissues related to Cataract 25:

39
Eye, Endothelial

Publications for Cataract 25

Variations for Cataract 25

Expression for Cataract 25

Search GEO for disease gene expression data for Cataract 25.

Pathways for Cataract 25

GO Terms for Cataract 25

Cellular components related to Cataract 25 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.62 GJA8 MIP

Biological processes related to Cataract 25 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.43 BFSP2 CRYBB2 MIP
2 visual perception GO:0007601 9.35 BFSP2 CRYBA1 CRYBB2 GJA8 MIP
3 camera-type eye development GO:0043010 9.16 CRYBB2 GJA8
4 lens development in camera-type eye GO:0002088 8.92 CRYBA1 CRYGS GJA8 MIP

Molecular functions related to Cataract 25 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.02 BFSP2 CRYBA1 CRYBB2 CRYGS MIP

Sources for Cataract 25

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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