MCID: CTR027
MIFTS: 19

Cataract-Glaucoma malady

Categories: Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Cataract-Glaucoma

Aliases & Descriptions for Cataract-Glaucoma:

Name: Cataract-Glaucoma 50
Cataract-Glaucoma Syndrome 56

Characteristics:

Orphanet epidemiological data:

56
cataract-glaucoma syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 56 ORPHA162
ICD10 via Orphanet 34 Q12.0

Summaries for Cataract-Glaucoma

MalaCards based summary : Cataract-Glaucoma, also known as cataract-glaucoma syndrome, is related to persistent hyperplastic primary vitreous, autosomal recessive and lowe syndrome. An important gene associated with Cataract-Glaucoma is PITX3 (Paired Like Homeodomain 3). Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and reproductive system

Related Diseases for Cataract-Glaucoma

Diseases related to Cataract-Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous, autosomal recessive 11.1
2 lowe syndrome 11.0
3 armfield x-linked mental retardation syndrome 11.0
4 fuchs' heterochromic uveitis 11.0
5 cataract 10.4
6 pseudopterygium 9.9 OCRL PITX3
7 leukocyte adhesion deficiency 9.8 OCRL PITX3
8 senile cataract 9.8
9 cdkl5-related disorder 9.6 ATOH7 OCRL PITX3

Graphical network of the top 20 diseases related to Cataract-Glaucoma:



Diseases related to Cataract-Glaucoma

Symptoms & Phenotypes for Cataract-Glaucoma

GenomeRNAi Phenotypes related to Cataract-Glaucoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.77 PITX3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.77 ATOH7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.77 PITX3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.77 PITX3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.77 OCRL
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.77 PITX3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.77 ATOH7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.77 ATOH7 OCRL
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.77 OCRL PITX3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.77 PITX3 ATOH7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.77 OCRL

MGI Mouse Phenotypes related to Cataract-Glaucoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 ATOH7 OCRL PITX3
2 vision/eye MP:0005391 8.8 ATOH7 OCRL PITX3

Drugs & Therapeutics for Cataract-Glaucoma

Interventional clinical trials:


id Name Status NCT ID Phase
1 Comparison of Phacotrabeculectomy and Trabeculectomy in the Treatment of Primary Angle-closure Glaucoma (PACG) Completed NCT01298635
2 An Epidemiologic Study of Disease Progression in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration (Proxima A). Active, not recruiting NCT02479386

Search NIH Clinical Center for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

MalaCards organs/tissues related to Cataract-Glaucoma:

39
Eye

Publications for Cataract-Glaucoma

Articles related to Cataract-Glaucoma:

(show all 16)
id Title Authors Year
1
Human aqueous humor proteome in cataract, glaucoma and pseudoexfoliation syndrome. ( 27193151 )
2016
2
Combined cataract-glaucoma surgery using the intracanalicular Eyepass glaucoma implant: first clinical results of a prospective pilot study. ( 18242448 )
2008
3
Knowledge about cataract, glaucoma, and age related macular degeneration in the Hong Kong Chinese population. ( 12234882 )
2002
4
Circumferential perilimbal anesthesia for combined cataract glaucoma surgery. ( 10100254 )
1999
5
A prospective randomized comparison of two techniques of combined cataract-glaucoma surgery. ( 10541897 )
1999
6
Cataract, glaucoma and season of birth amongst patients born on the Indian subcontinent. ( 10218303 )
1998
7
A new technique for combined cataract/glaucoma procedures in patients on chronic miotics. ( 8351096 )
1993
8
Combined cataract/glaucoma procedures in patients on chronic miotics. ( 8259258 )
1993
9
Combined cataract-glaucoma surgery using the THC:YAG (holmium) laser ab interno without gonioscopy. ( 1436972 )
1992
10
Combined cataract-glaucoma operation and its complications with the 7-S-intraocular lens. ( 3595960 )
1987
11
The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. ( 7444756 )
1980
12
Combined simultaneous cataract glaucoma surgery. ( 360803 )
1978
13
Combined cataract-glaucoma operation. ( 1070879 )
1976
14
The partial-punch: a new combined cataract-glaucoma operation. ( 1264419 )
1976
15
A simultaneous cataract-glaucoma operation. ( 13712279 )
1960
16
Miscellaneous ophthalmic surgery, including two techniques of keratoplasty, cataract, glaucoma, keratectomies and muscles. ( 20261921 )
1947

Variations for Cataract-Glaucoma

Expression for Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for Cataract-Glaucoma

GO Terms for Cataract-Glaucoma

Sources for Cataract-Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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