MCID: CTR027
MIFTS: 21

Cataract-Glaucoma

Categories: Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Cataract-Glaucoma

MalaCards integrated aliases for Cataract-Glaucoma:

Name: Cataract-Glaucoma 49
Cataract-Glaucoma Syndrome 55

Characteristics:

Orphanet epidemiological data:

55
cataract-glaucoma syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 55 ORPHA162
ICD10 via Orphanet 33 Q12.0

Summaries for Cataract-Glaucoma

MalaCards based summary : Cataract-Glaucoma, also known as cataract-glaucoma syndrome, is related to cataract and persistent hyperplastic primary vitreous, autosomal recessive. An important gene associated with Cataract-Glaucoma is PITX3 (Paired Like Homeodomain 3). Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cataract-Glaucoma

Diseases related to Cataract-Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cataract 29.7 OCRL PITX3
2 persistent hyperplastic primary vitreous, autosomal recessive 11.2
3 armfield x-linked mental retardation syndrome 11.0
4 lowe oculocerebrorenal syndrome 11.0
5 fuchs' heterochromic uveitis 11.0
6 macular degeneration, age-related, 1 10.0
7 aging 9.8
8 microvascular complications of diabetes 5 9.8
9 senile cataract 9.8
10 lens disease 9.5 OCRL PITX3

Graphical network of the top 20 diseases related to Cataract-Glaucoma:



Diseases related to Cataract-Glaucoma

Symptoms & Phenotypes for Cataract-Glaucoma

GenomeRNAi Phenotypes related to Cataract-Glaucoma according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.77 PITX3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.77 ATOH7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.77 PITX3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.77 PITX3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.77 OCRL
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.77 PITX3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.77 ATOH7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.77 ATOH7 OCRL
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.77 PITX3 OCRL
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.77 ATOH7 PITX3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.77 OCRL

MGI Mouse Phenotypes related to Cataract-Glaucoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.13 ATOH7 OCRL PITX3
2 vision/eye MP:0005391 8.8 ATOH7 OCRL PITX3

Drugs & Therapeutics for Cataract-Glaucoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Phacotrabeculectomy and Trabeculectomy in the Treatment of Primary Angle-closure Glaucoma (PACG) Completed NCT01298635
2 A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration Active, not recruiting NCT02479386

Search NIH Clinical Center for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

MalaCards organs/tissues related to Cataract-Glaucoma:

38
Eye

Publications for Cataract-Glaucoma

Articles related to Cataract-Glaucoma:

(show all 16)
# Title Authors Year
1
Human aqueous humor proteome in cataract, glaucoma and pseudoexfoliation syndrome. ( 27193151 )
2016
2
Combined cataract-glaucoma surgery using the intracanalicular Eyepass glaucoma implant: first clinical results of a prospective pilot study. ( 18242448 )
2008
3
Knowledge about cataract, glaucoma, and age related macular degeneration in the Hong Kong Chinese population. ( 12234882 )
2002
4
Circumferential perilimbal anesthesia for combined cataract glaucoma surgery. ( 10100254 )
1999
5
A prospective randomized comparison of two techniques of combined cataract-glaucoma surgery. ( 10541897 )
1999
6
Cataract, glaucoma and season of birth amongst patients born on the Indian subcontinent. ( 10218303 )
1998
7
Combined cataract/glaucoma procedures in patients on chronic miotics. ( 8259258 )
1993
8
A new technique for combined cataract/glaucoma procedures in patients on chronic miotics. ( 8351096 )
1993
9
Combined cataract-glaucoma surgery using the THC:YAG (holmium) laser ab interno without gonioscopy. ( 1436972 )
1992
10
Combined cataract-glaucoma operation and its complications with the 7-S-intraocular lens. ( 3595960 )
1987
11
The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. ( 7444756 )
1980
12
Combined simultaneous cataract glaucoma surgery. ( 360803 )
1978
13
Combined cataract-glaucoma operation. ( 1070879 )
1976
14
The partial-punch: a new combined cataract-glaucoma operation. ( 1264419 )
1976
15
A simultaneous cataract-glaucoma operation. ( 13712279 )
1960
16
Miscellaneous ophthalmic surgery, including two techniques of keratoplasty, cataract, glaucoma, keratectomies and muscles. ( 20261921 )
1947

Variations for Cataract-Glaucoma

Expression for Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for Cataract-Glaucoma

GO Terms for Cataract-Glaucoma

Sources for Cataract-Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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