MCID: CTR027
MIFTS: 34

Cataract-Glaucoma malady

Eye, Fetal categories

Summaries for Cataract-Glaucoma

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cataract-Glaucoma is related to diabetic cataract and cataract 19. An important gene associated with Cataract-Glaucoma is PITX3 (paired-like homeodomain 3), and among its related pathways are Heart Development and Wnt / Hedgehog / Notch. The compounds ptx1 and glycyrrhetinic acid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related mouse phenotypes are pigmentation and taste/olfaction.

Aliases & Classifications for Cataract-Glaucoma

Sources:
43NIH Rare Diseases, 49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Eye


Characteristics (Orphanet epidemiological data):

49
cataract-glaucoma:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

cataract-glaucoma 43 49


External Ids:

ICD10 via Orphanet26 Q12.0

Related Diseases for Cataract-Glaucoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Cataract-Glaucoma:



Diseases related to cataract-glaucoma

Clinical Features for Cataract-Glaucoma

Drugs & Therapeutics for Cataract-Glaucoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cataract-Glaucoma

Drug clinical trials:

Search ClinicalTrials for Cataract-Glaucoma

Search NIH Clinical Center for Cataract-Glaucoma

Search CenterWatch for Cataract-Glaucoma

Genetic Tests for Cataract-Glaucoma

Anatomical Context for Cataract-Glaucoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cataract-Glaucoma:

33
Endothelial

Animal Models for Cataract-Glaucoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cataract-Glaucoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.2OTX2, PITX3
2MP:00053949.2SOX2, PAX6, OTX2
3MP:00053778.5PAX6, OTX2, GJA1, SOX2
4MP:00053818.5SOX2, PITX2, FOXC1, PAX6, OTX2
5MP:00053828.1FOXC1, GJA1, SOX2, PITX2, OTX2, PAX6
6MP:00053698.1PAX6, PITX2, FOXC1, OTX2, GJA1, SOX2
7MP:00053808.1PAX6, GJA1, FOXC1, SOX2, OTX2, PITX2
8MP:00107718.0PITX3, FOXC1, SOX2, PAX6, GJA1
9MP:00053887.9OTX2, GJA1, PITX3, PITX2, FOXC1, SOX2
10MP:00053867.8PITX3, SOX2, PAX6, OTX2, GJA1, AKR1B1
11MP:00053797.6TDRD7, PITX3, FOXC1, SOX2, OTX2, PITX2
12MP:00036317.5PAX6, SOX2, FOXC1, TDRD7, OTX2, GJA1
13MP:00053847.5TDRD7, PITX3, PAX6, OTX2, PITX2, SOX2
14MP:00053857.5GJA1, PAX6, GSR, FOXC1, PITX2, OTX2
15MP:00053907.4SOX2, PITX3, FOXC1, PITX2, AKR1B1, OTX2
16MP:00053897.2TDRD7, GJA1, PAX6, OTX2, PITX3, FOXC1
17MP:00107687.1AKR1B1, FOXC1, PITX2, OCRL, PAX6, GJA1
18MP:00028736.9OCRL, GJA1, OTX2, GSR, SOX2, PAX6
19MP:00053786.9PAX6, PITX2, SOX2, PITX3, AKR1B1, OCRL
20MP:00053766.9OTX2, GJA1, OCRL, AKR1B1, PITX2, PITX3
21MP:00053915.8TDRD7, GJA1, OTX2, PAX6, GSR, AKR1B1

Publications for Cataract-Glaucoma

Sources:
51PubMed
See all sources

Articles related to Cataract-Glaucoma:

(show top 50)    (show all 103)
idTitleAuthorsYear
1
New options for combined cataract and glaucoma surgery. (24389806)
2014
2
Early postoperative safety and surgical outcomes after implantation of a suprachoroidal micro-stent for the treatment of open-angle glaucoma concomitant with cataract surgery. (23506920)
2013
3
Long-term risk of glaucoma after congenital cataract surgery. (23639132)
2013
4
Refractive Outcomes of Combined Cataract and Glaucoma Surgery. (24247998)
2013
5
Long-term risk of glaucoma after congenital cataract surgery. (23953162)
2013
6
Combined cataract and glaucoma surgery: the effect of pupil enlargement on surgical outcomes (an american ophthalmological society thesis). (24385672)
2013
7
Secondary glaucoma after pediatric cataract surgery. (23638427)
2013
8
Effects of combined phacoemulsification and viscogoniosynechialysis versus trabeculectomy in patients with primary angle-closure glaucoma and coexisting cataract. (22739037)
2012
9
Combined iStent trabecular micro-bypass stent implantation and phacoemulsification for coexistent open-angle glaucoma and cataract: a long-term study. (22275344)
2012
10
Using multiple trabecular micro-bypass stents in cataract patients to treat open-angle glaucoma. (22980724)
2012
11
Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine. (21883446)
2012
12
Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract. (22159018)
2012
13
Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: two-year follow-up. (22814041)
2012
14
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. (21436445)
2011
15
Subcutaneous nodules, arthropathy, coarse face, cataract and glaucoma: a newly recognized syndrome. (20802309)
2011
16
Trends in rates of primary angle closure glaucoma and cataract surgery in England from 1968 to 2004. (19295372)
2009
17
Combined trabeculectomy and cataract extraction versus trabeculectomy alone in primary angle-closure glaucoma. (19383599)
2009
18
Incidence of early-onset glaucoma after infant cataract extraction with and without intraocular lens implantation. (19429583)
2009
19
Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome. (17561259)
2008
20
Combined cataract-glaucoma surgery using the intracanalicular Eyepass glaucoma implant: first clinical results of a prospective pilot study. (18242448)
2008
21
Exfoliation syndrome: effects of cataract surgery on glaucoma. (19006713)
2008
22
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. (18958304)
2008
23
Chromosomal rearrangements and novel genes in disorders of eye development, cataract and glaucoma. (18637741)
2008
24
Safety and efficacy of manual small incision cataract surgery for phacolytic glaucoma. (17322458)
2007
25
The clinical outcomes of cataract extraction by phacoemulsification in eyes with primary angle-closure glaucoma (PACG) and co-existing cataract: a prospective case series. (16865015)
2006
26
Cataracts and glaucoma in patients with oculocerebrorenal syndrome. (12963605)
2003
27
Knowledge about cataract, glaucoma, and age related macular degeneration in the Hong Kong Chinese population. (12234882)
2002
28
Natural therapies for ocular disorders, part two: cataracts and glaucoma. (11302779)
2001
29
Cathepsin A activity in the aqueous humor in patients with cataract, absolute glaucoma and intraocular tumors]. (10526436)
1999
30
Cataract, glaucoma and season of birth amongst patients born on the Indian subcontinent. (10218303)
1998
31
Neovascular glaucoma developing after uncomplicated cataract surgery for heavily irradiated eyes. (9224462)
1997
32
An alternate way to manage patients with morgagnian cataracts and phacolytic glaucoma. (9475014)
1997
33
Cataract extraction and intraocular lens implantation in eyes with phacomorphic or phacolytic glaucoma. (8784641)
1996
34
Phacolytic glaucoma--its treatment by planned extracapsular cataract extraction with posterior chamber intraocular lens implantation. (7829178)
1994
35
Combined cataract/glaucoma procedures in patients on chronic miotics. (8259258)
1993
36
A new technique for combined cataract/glaucoma procedures in patients on chronic miotics. (8351096)
1993
37
Steroid induced glaucoma and cataract. (2807493)
1989
38
Primary angle closure glaucoma: extracapsular cataract extraction or filtering procedure? (3229905)
1988
39
Treatment of phacolytic glaucoma with extracapsular cataract extraction. (3211475)
1988
40
Effects of extracapsular cataract extraction with posterior chamber lens implantation on the development of neovascular glaucoma in diabetics. (2437281)
1987
41
Neovascular glaucoma after intracapsular and extracapsular cataract extraction in diabetic patients. (2420182)
1986
42
Neovascular glaucoma after intracapsular and extracapsular cataract extraction in diabetic patients. (2414993)
1985
43
Steroid-induced glaucoma and cataract in renal transplant recipients. (336581)
1977
44
Cataractogenic factors in patients with primary angle-closure glaucoma after peripheral iridectomy. (836659)
1977
45
Bullous keratopathy following lens extraction in eyes with acute glaucoma due to intumescent cataract. (958674)
1976
46
Combined cataract-glaucoma operation. (1070879)
1976
47
Cataract complicated by glaucoma or by corneal disease. (5499907)
1970
48
Glaucoma, miotic therapy and cataract. I. The frequency of anterior subcapsular vacuoles in glaucoma eyes treated with echothiophate (Phospholine Iodide), pilocarpine or pilocarpine-eserine, and in nonglaucomatous untreated eyes with common senile cataract. (5694669)
1968
49
A simultaneous cataract-glaucoma operation. (13712279)
1960
50
Posterior sclerotomy and lens extraction in acute glaucoma secondary to senile cataract. (20982429)
1946

Genetic Variations for Cataract-Glaucoma

Expression for genes affiliated with Cataract-Glaucoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cataract-Glaucoma

Search GEO for disease gene expression data for Cataract-Glaucoma.

Pathways for genes affiliated with Cataract-Glaucoma

Sources:
38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Cataract-Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PITX2, FOXC1
29.4OTX2, FOXC1, SOX2
39.1SOX2, FOXC1, PAX6
48.6PAX6, OTX2, GJA1, SOX2

Compounds for genes affiliated with Cataract-Glaucoma

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR
See all sources

Compounds related to Cataract-Glaucoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ptx14510.0PITX2, PITX3
2glycyrrhetinic acid45 2410.6GJA1, AKR1B1
3tolrestat45 1110.4GSR, AKR1B1
4s-nitroso-n-acetylpenicillamine459.3AKR1B1, GJA1
5methylglyoxal45 2910.3AKR1B1, GSR
6phenylbutyrate459.3GSR, GJA1
7lycopene45 2410.2GSR, GJA1
8nadp+459.2AKR1B1, GSR
9gsno458.8AKR1B1, GSR
10epinephrine45 11 2410.8GSR, AKR1B1, PITX2
11arginine458.1GSR, PAX6, AKR1B1, PITX2

GO Terms for genes affiliated with Cataract-Glaucoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cataract-Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.3PITX2, SOX2, FOXC1
2cytoplasmGO:0057377.0SOX2, FOXC1, PITX2, AKR1B1, OCRL, OTX2
3nucleusGO:0056346.8PAX6, PITX2, OTX2, SOX2, FOXC1, PITX3

Biological processes related to Cataract-Glaucoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1lens fiber cell differentiationGO:07030610.1TDRD7, PITX3
2lens morphogenesis in camera-type eyeGO:00208910.1TDRD7, PITX3
3diencephalon morphogenesisGO:04885210.1OTX2, SOX2
4midbrain developmentGO:0309019.9OTX2, PITX3
5lacrimal gland developmentGO:0328089.8FOXC1, PAX6
6iris morphogenesisGO:0610729.7PITX2, PAX6
7positive regulation of epithelial cell differentiationGO:0308589.7PAX6, SOX2
8camera-type eye developmentGO:0430109.7FOXC1, PITX2
9positive regulation of neuroblast proliferationGO:0020529.6PAX6, SOX2
10neuron fate commitmentGO:0486639.6PAX6, SOX2
11pituitary gland developmentGO:0219839.5SOX2, PAX6
12negative regulation of neuron differentiationGO:0456659.4PAX6, SOX2
13eye developmentGO:0016549.4PAX6, FOXC1, SOX2
14lens development in camera-type eyeGO:0020889.4PITX3, PAX6, GJA1
15neuron migrationGO:0017649.2PITX2, PAX6, GJA1
16negative regulation of epithelial cell proliferationGO:0506809.1PAX6, SOX2
17in utero embryonic developmentGO:0017019.1FOXC1, GJA1, OCRL, PITX2
18regulation of transcription, DNA-dependentGO:0063558.9PITX3, SOX2, FOXC1, OTX2, PITX2
19positive regulation of transcription, DNA-dependentGO:0458938.8PITX3, OTX2, FOXC1, SOX2, PAX6
20positive regulation of transcription from RNA polymerase II promoterGO:0459448.7SOX2, FOXC1, PAX6, OTX2, PITX2

Molecular functions related to Cataract-Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.5PITX2, FOXC1
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.4OTX2, SOX2, PITX2
3transcription factor bindingGO:0081349.1FOXC1, PITX2, PAX6
4sequence-specific DNA bindingGO:0435659.0FOXC1, PITX3, OTX2, SOX2
5sequence-specific DNA binding transcription factor activityGO:0037008.2PITX3, SOX2, FOXC1, PAX6, OTX2, PITX2

Products for genes affiliated with Cataract-Glaucoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cataract-Glaucoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet