MCID: CTS005
MIFTS: 43

Catastrophic Antiphospholipid Syndrome malady

Immune, Blood categories

Summaries for Catastrophic Antiphospholipid Syndrome

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64Wikipedia, 33MalaCards
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Wikipedia:64 Catastrophic antiphospholipid syndrome, CAPS, also known as Asherson’s syndrome, is an acute and... more...

MalaCards: Catastrophic Antiphospholipid Syndrome, also known as thrombotic storm, is related to antiphospholipid syndrome and systemic lupus erythematosus. An important gene associated with Catastrophic Antiphospholipid Syndrome is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Selected targets of HNF1. The compounds warfarin and serine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Catastrophic Antiphospholipid Syndrome

Sources:
43NIH Rare Diseases, 20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Blood


Aliases & Descriptions:

catastrophic antiphospholipid syndrome 43
thrombotic storm 43 20
catastrophic antiphospholipid antibody syndrome 43


Related Diseases for Catastrophic Antiphospholipid Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Catastrophic Antiphospholipid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1antiphospholipid syndrome31.9ADAMTS13, APOH, F8, F5, MTHFR, CD40LG
2systemic lupus erythematosus30.7APOH, F8, CD40LG, F3, CFH, ADAMTS13
3sepsis30.4F5, PROC, F3, SERPINE1, ADAMTS13
4purpura fulminans30.4F5, PROC
5acute leukemia30.4MTHFR
6ovarian hyperstimulation syndrome30.2F5
7coronary thrombosis30.2SERPINE1, F3
8septic shock30.2SERPINE1, F3, F5
9protein c deficiency30.2APOH, F5, MTHFR, PROC, SERPINE1
10hellp syndrome30.2APOH, F5, MTHFR, SERPINE1, ADAMTS13
11thrombocytopenia30.2ADAMTS13, CFH, F3, CD40LG, F5, F8
12protein s deficiency30.2APOH, F8, F5, MTHFR, F3, SERPINE1
13thromboembolism30.2APOH, F8, F5, MTHFR, PROC, F3
14n syndrome10.8
15micro syndrome10.6
16mass syndrome10.4
17polyarteritis nodosa10.3
18adult syndrome10.3
19typhoid fever10.3
20char syndrome10.3
21image syndrome10.3
22cardiogenic shock10.3
23splenic marginal zone lymphoma10.3
24acute myelomonocytic leukemia10.3
25pediatric systemic lupus erythematosus10.3
26graft versus host disease10.2
27crescentic glomerulonephritis10.2
28acute interstitial pneumonia10.2
29acute chest syndrome10.2
30adult respiratory distress syndrome10.2
31proliferative glomerulonephritis10.2
32pancytopenia10.2
33adult-onset still's disease10.2
34sclerosing cholangitis10.2
35invasive aspergillosis10.2
36arthritis10.2
37aspergillosis10.2
38bone marrow necrosis10.2
39primary sclerosing cholangitis10.2
40chronic graft versus host disease10.2
41warfarin syndrome10.2
42kikuchi disease10.2
43protein r deficiency10.2
44susac syndrome10.2
45hemorrhage, intracerebral10.2
46kimura disease10.1
47ulcerative colitis10.1
48retinal artery occlusion10.0APOH
49mixed connective tissue disease10.0APOH
50sneddon syndrome10.0APOH

Graphical network of the top 20 diseases related to Catastrophic Antiphospholipid Syndrome:



Diseases related to catastrophic antiphospholipid syndrome

Clinical Features for Catastrophic Antiphospholipid Syndrome

Drugs & Therapeutics for Catastrophic Antiphospholipid Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Catastrophic Antiphospholipid Syndrome

Drug clinical trials:

Search ClinicalTrials for Catastrophic Antiphospholipid Syndrome

Search NIH Clinical Center for Catastrophic Antiphospholipid Syndrome

Search CenterWatch for Catastrophic Antiphospholipid Syndrome

Genetic Tests for Catastrophic Antiphospholipid Syndrome

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20GeneTests
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Genetic tests related to Catastrophic Antiphospholipid Syndrome:

id Genetic test Affiliating Genes
1 Thrombotic Storm20

Anatomical Context for Catastrophic Antiphospholipid Syndrome

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33MalaCards
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MalaCards organs/tissues related to Catastrophic Antiphospholipid Syndrome:

33
Bone marrow, Heart, Liver, Lung, Breast, Skin, Endothelial, Fetal liver, Fetal lung

Animal Models for Catastrophic Antiphospholipid Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Catastrophic Antiphospholipid Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.1CD40LG, F3, CFH
2MP:00053977.5PROC, CD40LG, F3, CFH, SERPINE1, ADAMTS13
3MP:00053877.3F8, ADAMTS13, SERPINE1, CFH, F3, CD40LG
4MP:00053766.1APOH, ADAMTS13, SERPINE1, CFH, F3, CD40LG
5MP:00107686.0PROC, ADAMTS13, SERPINE1, CFH, F3, CD40LG

Publications for Catastrophic Antiphospholipid Syndrome

Sources:
51PubMed
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Articles related to Catastrophic Antiphospholipid Syndrome:

(show top 50)    (show all 212)
idTitleAuthorsYear
1
Catastrophic antiphospholipid syndrome and pregnancy: an experience of 13 cases. (23676524)
2013
2
A 13-year-old girl with pancytopenia. Catastrophic antiphospholipid syndrome. (23556525)
2013
3
Catastrophic antiphospholipid syndrome. (23278947)
2013
4
Recurrence of cutaneous necrosis in an infant with probable catastrophic antiphospholipid syndrome. (22957833)
2013
5
Recurrent episodes of hemorrhagic alveolitis in relapsing catastrophic antiphospholipid syndrome: the same side of the dark moon. (24362787)
2013
6
Catastrophic antiphospholipid syndrome: a case series. (24340837)
2013
7
Catastrophic antiphospholipid syndrome in the obstetric period. (22030072)
2012
8
Multiple thromboemboli associated to two occult tumors: a case mimicking catastrophic antiphospholipid syndrome. (21459648)
2011
9
Comparison of surgical methods in catastrophic antiphospholipid syndrome (CAPS). (21453587)
2011
10
Catastrophic antiphospholipid syndrome associated with methicillin-resistant Staphylococcus aureus infection. (20974295)
2011
11
Reversible cardiac valvular disease in catastrophic antiphospholipid syndrome. (20508270)
2010
12
Catastrophic cerebral antiphospholipid syndrome presenting as cerebral infarction with haemorrhagic transformation after sudden withdrawal of warfarin in a patient with primary antiphospholipid syndrome. (22242060)
2010
13
Catastrophic antiphospholipid syndrome in a child with trisomy 21. An acquired thrombopathy with a discussion of thrombopathies in childhood. (19968487)
2010
14
Successful extracorporeal membrane oxygenation for refractory cardiogenic shock due to the catastrophic antiphospholipid syndrome. (20921559)
2010
15
Catastrophic antiphospholipid syndrome and rituximab: a new report]. (20187361)
2009
16
The catastrophic antiphospholipid syndrome in Serbia: diagnostic and management problems. (19048415)
2009
17
Catastrophic antiphospholipid syndrome triggered by sepsis. (19096893)
2009
18
The CAPS Registry: morbidity and mortality of the catastrophic antiphospholipid syndrome. (19671791)
2009
19
Morbidity and mortality in the catastrophic antiphospholipid syndrome: pathophysiology, causes of death, and prognostic factors. (18720310)
2008
20
Catastrophic antiphospholipid syndrome presenting with multiorgan failure and gangrenous lesions of the skin. (18388074)
2008
21
Catastrophic antiphospholipid syndrome in a 77-year-old man. (19098955)
2008
22
Severe limb necrosis: primary thrombotic microangiopathy or "seronegative" catastrophic antiphospholipid syndrome? A diagnostic dilemma. (17256103)
2007
23
Catastrophic antiphospholipid syndrome: report of 4 cases. (18046677)
2007
24
Catastrophic antiphospholipid syndrome: therapeutic developments. (20477672)
2007
25
The clinical spectrum of catastrophic antiphospholipid syndrome in the absence and presence of lupus. (17304658)
2007
26
Catastrophic antiphospholipid syndrome in a 7-year-old girl. (16598412)
2007
27
Catastrophic antiphospholipid syndrome with heart involvement: diagnostic utility of the cardiac MRI. (17113663)
2007
28
Lessons from the catastrophic antiphospholipid syndrome (CAPS) registry. (17138248)
2006
29
Catastrophic antiphospholipid syndrome. (16932661)
2006
30
Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors. (17138246)
2006
31
Alveolar and serum antiphospholipid antibodies in acute respiratory distress syndrome associated with catastrophic antiphospholipid syndrome. (16474036)
2006
32
Catastrophic antiphospholipid syndrome and Kikuchi-Fujimoto disease: the first case reported. (16425578)
2005
33
Liver involvement in catastrophic antiphospholipid syndrome. (15168783)
2004
34
Meningococcal purpura fulminans in a patient with systemic lupus erythematosus: a mimic for catastrophic antiphospholipid antibody syndrome? (15201656)
2004
35
Primary, Secondary, Catastrophic Antiphospholipid Syndrome: is there a difference? (15507265)
2004
36
Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome. (15111789)
2004
37
Catastrophic antiphospholipid syndrome; a "CATASTROPHIC" case of systemic lupus erythematosus. (15704545)
2004
38
The catastrophic antiphospholipid syndrome--Asherson's syndrome. (14593307)
2003
39
Neurological involvement as a poor prognostic factor in catastrophic antiphospholipid syndrome: autopsy findings in 12 cases. (12630752)
2003
40
Catastrophic antiphospholipid syndrome: need for a reappraisal. (11508607)
2001
41
Catastrophic antiphospholipid syndrome in cancer. (11204029)
2000
42
The catastrophic antiphospholipid syndrome: a review of pathogenesis, clinical features and treatment. (10804900)
2000
43
Catastrophic antiphospholipid syndrome associated with anti-beta-2-glycoprotein I IgA. (10334687)
1999
44
The role of microvasculopathy in the catastrophic antiphospholipid syndrome: comment on the article by Neuwelt et al. (9550493)
1998
45
Anti beta 2-glycoprotein I antibodies in a patient with catastrophic antiphospholipid syndrome. (8608682)
1995
46
Catastrophic antiphospholipid syndrome with fatal acute course in rheumatoid arthritis. (7473489)
1995
47
Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency. (7620085)
1995
48
"Catastrophic antiphospholipid syndrome crisis". (8070173)
1994
49
Catastrophic antiphospholipid syndrome (CAS): a rare manifestation of the antiphospholipid antibody syndrome. (8299260)
1993
50
The catastrophic antiphospholipid syndrome. (1593568)
1992

Genetic Variations for Catastrophic Antiphospholipid Syndrome

Expression for genes affiliated with Catastrophic Antiphospholipid Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Catastrophic Antiphospholipid Syndrome

Search GEO for disease gene expression data for Catastrophic Antiphospholipid Syndrome.

Pathways for genes affiliated with Catastrophic Antiphospholipid Syndrome

Sources:
54Reactome, 50PharmGKB, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 30KEGG
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Compounds for genes affiliated with Catastrophic Antiphospholipid Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.4APOH, PROC
2serine4510.2F8, ADAMTS13
3aspartate4510.1F8, CD40LG
4cardiolipin45 1111.1CRLS1, CFH
5coumarins4510.0APOH, F3
6fluorescein45 1110.7F3, CD40LG
7anisodamine459.7SERPINE1, F3
8ticlopidine45 1110.6ADAMTS13, F3, APOH
9phosphatidylserine45 29 1111.6APOH, F8, F3
10rituximab45 50 1111.5CD40LG, APOH, ADAMTS13, F8
11ivig459.4APOH, F8, CD40LG
12dextran sulfate459.4F5, CD40LG, APOH
13p00001459.4F8, SERPINE1, MTHFR
14tranexamic acid45 1110.4SERPINE1, F8, F3
15phosphatidylethanolamine45 1110.2APOH, F5, F8
16Drotrecogin alfa119.2F8, F5, SERPINE1
17inogatran459.1F5, F3
18gamma-carboxyglutamic acid459.1PROC, F5, F3
19heparin45 29 11 2412.0CD40LG, MTHFR, ADAMTS13, F8, APOH
20cacl2459.0F8, F5, F3
21mycophenolate mofetil45 50 1111.0SERPINE1, CD40LG, F5
22ecarin458.9F5, F3
23vitamin b12458.9APOH, CD40LG, MTHFR, F5
24cyclosporin a45 29 6010.8MTHFR, CD40LG, F8, CFH, ADAMTS13
25kaolin458.8F8, APOH, F5, F3
26uric acid45 249.8MTHFR, SERPINE1, F5, APOH
27nacl458.8F5, ADAMTS13, CFH, F8
28folate458.8MTHFR, CD40LG, F5, APOH
29ristocetin458.7ADAMTS13, F8, F5, F3
30kininogen458.7F3, SERPINE1, F5, APOH
31protamine458.7SERPINE1, F5, F3
32metformin45 50 1110.7F5, SERPINE1, MTHFR
33phospholipid458.4APOH, F8, F3, PROC, F5
34prostacyclin458.3F3, F5, F8, APOH, SERPINE1
35desmopressin45 60 29 1111.3F8, ADAMTS13, F5, SERPINE1, F3
36polysaccharide458.3F3, F8, F5, CD40LG, CFH
37hirudin458.2F5, SERPINE1, F3, CD40LG, F8
38cholesterol45 29 11 2411.0F8, MTHFR, CFH, SERPINE1, APOH, F5
39epinephrine45 11 249.9F3, CD40LG, F8, F5
40estrogen457.9F8, F5, MTHFR, CD40LG, SERPINE1, APOH
41vegf457.9SERPINE1, F3, CD40LG, F5, F8, APOH
42homocysteine45 248.8APOH, F8, SERPINE1, F3, MTHFR, F5
43alanine457.7F8, F5, MTHFR, CD40LG, CFH, F3
44endotoxin457.6F5, APOH, F8, CD40LG, F3, SERPINE1
45cysteine457.6F5, CD40LG, F8, MTHFR, CFH, F3
46retinoic acid45 248.6SERPINE1, CFH, CD40LG, MTHFR, F5, F3
47cyclophosphamide45 50 119.5SERPINE1, ADAMTS13, F3, MTHFR, F5, F8
48aspirin45 50 29 2410.4F5, SERPINE1, F3, APOH, F8, MTHFR
49creatinine457.1F5, ADAMTS13, APOH, F3, CD40LG, MTHFR
50fibrinogen456.5F8, SERPINE1, F5, ADAMTS13, CFH, F3

GO Terms for genes affiliated with Catastrophic Antiphospholipid Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, F3, APOH
2platelet alpha granule lumenGO:0310938.5SERPINE1, F5, F8
3extracellular spaceGO:0056156.8ADAMTS13, APOH, F8, F5, CD40LG, F3

Biological processes related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.8F8, APOH
2negative regulation of fibrinolysisGO:0519189.7APOH, SERPINE1
3negative regulation of blood coagulationGO:0301959.6APOH, PROC, SERPINE1
4positive regulation of blood coagulationGO:0301949.5SERPINE1, APOH
5platelet degranulationGO:0025768.8SERPINE1, F5, F8
6platelet activationGO:0301688.2ADAMTS13, SERPINE1, CD40LG, F5, F8
7blood coagulationGO:0075967.9F8, F5, PROC, F3, SERPINE1

Molecular functions related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6ADAMTS13, SERPINE1, CFH, F3, PROC, F5

Products for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Sources for Catastrophic Antiphospholipid Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet