MCID: CTS005
MIFTS: 52

Catastrophic Antiphospholipid Syndrome malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases categories
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Summaries for Catastrophic Antiphospholipid Syndrome

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Wikipedia:65 Catastrophic antiphospholipid syndrome, CAPS, also known as Asherson?s syndrome, is an acute and complex... more...

MalaCards based summary: Catastrophic Antiphospholipid Syndrome, also known as catastrophic antiphospholipid antibody syndrome, is related to purpura and lupus erythematosus. An important gene associated with Catastrophic Antiphospholipid Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Selected targets of HNF1 and Collagen biosynthesis and modifying enzymes. The compounds CL(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/18:2(9Z,12Z)/16:0) and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related mouse phenotypes are nervous system and cardiovascular system.

Aliases & Classifications for Catastrophic Antiphospholipid Syndrome

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Catastrophic Antiphospholipid Syndrome, Aliases & Descriptions:

Name: Catastrophic Antiphospholipid Syndrome 42 62
Catastrophic Antiphospholipid Antibody Syndrome 42 62
 
Thrombotic Storm 42 20


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


Related Diseases for Catastrophic Antiphospholipid Syndrome

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Diseases related to Catastrophic Antiphospholipid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.1ADAMTS13
2lupus erythematosus30.7CD40LG, F5, F3, APOH
3antiphospholipid syndrome30.6CD40LG, F5, F8, MTHFR, F3, ADAMTS13
4hemolytic anemia30.4CFH, APOH, ADAMTS13, F3
5sepsis30.3SERPINE1, ADAMTS13, PROC, F3, F5
6systemic lupus erythematosus30.3CFH, APOH, ADAMTS13, F3, F8, CD40LG
7septic shock30.2F5, F3, SERPINE1
8hypertension30.1F5, MTHFR, SERPINE1
9rheumatoid arthritis30.0CD40LG, MTHFR, APOH, HLA-DRB4
10pulmonary embolism29.9APOH, F3, MTHFR, F5
11thrombocytopenia29.8CFH, APOH, ADAMTS13, F3, F8, F5
12hellp syndrome29.6APOH, SERPINE1, ADAMTS13, MTHFR, F5
13pregnancy loss29.3APOH, F3, MTHFR, CD40LG, F5, F8
14protein s deficiency29.2F5, F8, MTHFR, F3, SERPINE1, APOH
15retinal artery occlusion10.6APOH
16sneddon syndrome10.6APOH
17syphilis10.5APOH
18hemorrhagic fever10.4CD40LG
19pancreatitis10.4
20heparin-induced thrombocytopenia10.4
21scrub typhus10.4CD40LG
22meningococcemia10.4F5
23cardiac tamponade10.4F8
24hepatitis a10.4F8
25sagittal sinus thrombosis10.4F5
26branch retinal artery occlusion10.4F5
27thrombotic thrombocytopenic purpura, acquired10.3CFH, ADAMTS13
28thrombophlebitis10.3APOH, F8
29glomerulonephritis10.3
30acute interstitial pneumonia10.3
31typhoid fever10.3
32polyarteritis nodosa10.3
33endocarditis10.3
34pneumonia10.3
35endotheliitis10.3
36cardiogenic shock10.3
37patent foramen ovale10.3F5
38cryoglobulinemia10.3APOH, CD40LG
39eclampsia10.3MTHFR
40hemolytic-uremic syndrome10.3CFH, ADAMTS13
41leukemia10.3
42splenic marginal zone lymphoma10.3
43acute myelomonocytic leukemia10.3
44pediatric systemic lupus erythematosus10.3
45mondor disease10.3APOH, F5
46prothrombin deficiency10.3APOH, F5
47retinal vascular occlusion10.3APOH, F5
48lyme disease10.2CD40LG, CFH
49coronary thrombosis10.2SERPINE1, F3
50viral hepatitis10.2F8

Graphical network of the top 20 diseases related to Catastrophic Antiphospholipid Syndrome:



Diseases related to catastrophic antiphospholipid syndrome

Symptoms for Catastrophic Antiphospholipid Syndrome

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Drugs & Therapeutics for Catastrophic Antiphospholipid Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Catastrophic Antiphospholipid Syndrome

Genetic Tests for Catastrophic Antiphospholipid Syndrome

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Genetic tests related to Catastrophic Antiphospholipid Syndrome:

id Genetic test Affiliating Genes
1 Thrombotic Storm20

Anatomical Context for Catastrophic Antiphospholipid Syndrome

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MalaCards organs/tissues related to Catastrophic Antiphospholipid Syndrome:

32
Liver, Bone, Bone marrow, Heart, Skin, Endothelial, Lung, Breast

Animal Models for Catastrophic Antiphospholipid Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Catastrophic Antiphospholipid Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9CD40LG, F5, MTHFR, F3, PROC, CFH
2MP:00053857.6CFH, SERPINE1, PROC, F3, F5, CD40LG
3MP:00053977.5CFH, SERPINE1, ADAMTS13, PROC, F3, F8
4MP:00053877.4CFH, SERPINE1, ADAMTS13, PROC, F3, F8
5MP:00107717.4SERPINE1, F3, MTHFR, F5, CD40LG
6MP:00053766.2CD40LG, CFH, APOH, SERPINE1, ADAMTS13, PROC
7MP:00107686.1CFH, APOH, SERPINE1, ADAMTS13, PROC, F3

Publications for Catastrophic Antiphospholipid Syndrome

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Articles related to Catastrophic Antiphospholipid Syndrome:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Multiple osteonecrotic lesions mimicking a piano keyboard in the spine of a patient with catastrophic antiphospholipid syndrome. (24838647)
2014
2
Catastrophic antiphospholipid syndrome and heparin-induced thrombocytopenia presenting with adrenal insufficiency caused by bilateral hemorrhagic adrenal infarction during sepsis. (24709482)
2014
3
A case of catastrophic antiphospholipid syndrome, which presented an acute interstitial pneumonia-like image on chest CT scan. (24533549)
2014
4
A case of catastrophic antiphospholipid syndrome, which presented an acute interstitial pneumonia-like image on chest CT scan. (23553659)
2013
5
Rituximab use in the catastrophic antiphospholipid syndrome: Descriptive analysis of the CAPS registry patients receiving rituximab. (23777822)
2013
6
Catastrophic antiphospholipid syndrome and pregnancy: an experience of 13 cases. (23676524)
2013
7
A 13-year-old girl with pancytopenia. Catastrophic antiphospholipid syndrome. (23556525)
2013
8
Catastrophic antiphospholipid syndrome with concurrent thrombotic and hemorrhagic manifestations. (23722230)
2013
9
The Hyperferritinemic Syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome. (23968282)
2013
10
Catastrophic antiphospholipid syndrome. (23278947)
2013
11
Vascular endothelial cell function in catastrophic antiphospholipid syndrome: a case report and review of the literature. (23762673)
2013
12
N2010 adult-onset Still's disease complicated by hemophagocytic syndrome and catastrophic antiphospholipid syndrome resulting in four limb amputation. (23781758)
2013
13
Relapsing catastrophic antiphospholipid syndrome potential role of microangiopathic hemolytic anemia in disease relapses. (22784445)
2013
14
Neurosurgical management for complicated catastrophic antiphospholipid syndrome. (24269552)
2013
15
8th International Congress on Autoimmunity: new perspectives for refractory catastrophic antiphospholipid syndrome. (23078059)
2012
16
Catastrophic antiphospholipid syndrome in a patient with V Leiden variant. (23319991)
2012
17
Severe abdominal pain as a presenting symptom of probable catastrophic antiphospholipid syndrome. (22711721)
2012
18
Multiple thromboemboli associated to two occult tumors: a case mimicking catastrophic antiphospholipid syndrome. (21459648)
2011
19
Eculizumab and renal transplantation in a patient with catastrophic antiphospholipid syndrome: effect of heparin on complement activation. (21335395)
2011
20
Catastrophic antiphospholipid syndrome (CAPS): update from the 'CAPS Registry'. (20353979)
2010
21
Reversible cardiac valvular disease in catastrophic antiphospholipid syndrome. (20508270)
2010
22
Infant with probable catastrophic antiphospholipid syndrome successfully managed with rituximab. (20478943)
2010
23
Catastrophic antiphospholipid syndrome complicated by cardiogenic shock - a case report]. (19650000)
2009
24
Massive cerebrovascular infarct due to the catastrophic antiphospholipid syndrome in a patient with idiopathic thrombocytopenic purpura. (19617232)
2009
25
Catastrophic antiphospholipid syndrome and rituximab: a new report]. (20187361)
2009
26
Catastrophic antiphospholipid syndrome: treatment, prognosis, and the risk of relapse. (19051065)
2009
27
Catastrophic antiphospholipid syndrome presenting as ischemic pancreatitis in systemic lupus erythematosus. (19734640)
2009
28
The catastrophic antiphospholipid syndrome in Serbia: diagnostic and management problems. (19048415)
2009
29
Catastrophic antiphospholipid syndrome in a patient with Down syndrome. (19762387)
2009
30
Relapsing catastrophic antiphospholipid syndrome: report of three cases. (17977582)
2008
31
A case of catastrophic antiphospholipid syndrome presenting with acute respiratory distress syndrome as the initial manifestation. (18651145)
2008
32
Reversible posterior leukoencephalopathy syndrome in catastrophic antiphospholipid syndrome. (17565204)
2007
33
Catastrophic antiphospholipid syndrome related to severe ovarian hyperstimulation. (16538387)
2007
34
Catastrophic antiphospholipid syndrome associated with malignancies (case report and review of the literature). (17283588)
2007
35
Severe limb necrosis: primary thrombotic microangiopathy or "seronegative" catastrophic antiphospholipid syndrome? A diagnostic dilemma. (17256103)
2007
36
Catastrophic antiphospholipid syndrome presenting with renal thrombotic microangiopathy and diffuse proliferative glomerulonephritis. (16539830)
2006
37
Catastrophic antiphospholipid syndrome: a rare cause of disseminated microvascular thrombotic injury - a case report with pathological and molecular correlative studies. (15743323)
2005
38
Refractory leg infection as an inducer of the catastrophic antiphospholipid syndrome. (15249331)
2004
39
Liver involvement in catastrophic antiphospholipid syndrome. (15168783)
2004
40
Combined plasmapheresis and immunosuppression as rescue treatment of a patient with catastrophic antiphospholipid syndrome occurring despite anticoagulation: a case report. (12945882)
2003
41
Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment. (17041346)
2002
42
Catastrophic antiphospholipid syndrome: clues to the pathogenesis from a series of 80 patients. (11704713)
2001
43
Catastrophic antiphospholipid syndrome. (10961585)
2000
44
Pathophysiology of the catastrophic antiphospholipid syndrome (CAPS). (10996834)
2000
45
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
46
Membranous obstruction of the inferior vena cava and extensive bone marrow necrosis associated with catastrophic antiphospholipid syndrome. (19078409)
1999
47
The pathogenesis of catastrophic antiphospholipid syndrome. (19078402)
1999
48
Anti beta 2-glycoprotein I antibodies in a patient with catastrophic antiphospholipid syndrome. (8608682)
1995
49
On the catastrophic antiphospholipid syndrome. A comment on the editorial by AlarcA^n-Segovia. (8070172)
1994
50
Catastrophic antiphospholipid syndrome (CAS): a rare manifestation of the antiphospholipid antibody syndrome. (8299260)
1993

Variations for Catastrophic Antiphospholipid Syndrome

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Expression for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Expression patterns in normal tissues for genes affiliated with Catastrophic Antiphospholipid Syndrome

Search GEO for disease gene expression data for Catastrophic Antiphospholipid Syndrome.

Pathways for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Compounds for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Compounds related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1CL(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/18:2(9Z,12Z)/16:0)249.8CRLS1, APOH
2ticlopidine44 1110.8F3, ADAMTS13, APOH
3CL(22:5(7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z)/18:2(9Z,12Z)/18:1(9Z))249.8CRLS1, APOH
4CL(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:3(8Z,11Z,14Z)/18:2(9Z,12Z)/18:1(9Z))249.7CRLS1, APOH
5CL(20:2(11Z,14Z)/18:2(9Z,12Z)/18:2(9Z,12Z)/18:2(9Z,12Z))249.7APOH, CRLS1
6CL(18:2(9Z,12Z)/18:1(11Z)/18:1(9Z)/16:1(9Z))249.7APOH, CRLS1
7coumarins449.6APOH, F3, F5
8gamma-carboxyglutamic acid449.6F3, PROC, F5
9CL(18:2(9Z,12Z)/18:2(9Z,12Z)/18:2(9Z,12Z)/18:1(9Z))249.6APOH, CRLS1
10anisodamine449.5F3, SERPINE1
11cacl2449.4F5, F8, F3
12rituximab44 50 1111.4F8, APOH, CD40LG, ADAMTS13
13fluorescein44 1110.4CD40LG, F5, F3
14phosphatidylethanolamine44 1110.4APOH, F8, F5
15CL(18:2(9Z,12Z)/18:1(9Z)/18:1(11Z)/16:0)249.4APOH, CRLS1
16dextran sulfate449.3F3, F5, APOH, CD40LG
17kaolin449.2F8, APOH, F3, F5
18ristocetin449.2F8, F3, ADAMTS13, F5
19tranexamic acid44 1110.2SERPINE1, F3, F8
20vitamin b12449.1CD40LG, F5, MTHFR, APOH
21nacl449.0F5, CFH, ADAMTS13, F8
22folate449.0F5, APOH, MTHFR, CD40LG
23p00001448.9F8, MTHFR, SERPINE1
24phospholipid448.9F8, PROC, F5, F3, APOH
25phosphatidylserine44 28 1110.8F8, CD40LG, F5, APOH, F3
26kininogen448.8F3, SERPINE1, APOH, F5
27polysaccharide448.8CFH, F3, F8, F5, CD40LG
28cyclosporin a44 28 6110.7CD40LG, CFH, F8, ADAMTS13, MTHFR
29tacrolimus44 50 1110.6SERPINE1, F3, CFH, F5
30uric acid44 249.6F5, APOH, MTHFR, SERPINE1
31prostacyclin448.4APOH, F5, SERPINE1, F3, F8
32desmopressin44 61 28 1111.4F5, F3, ADAMTS13, SERPINE1, F8
33warfarin44 50 24 1111.3F5, MTHFR, PROC, APOH, F8, F3
34hirudin448.3SERPINE1, F3, F5, CD40LG, F8
35alanine448.1CD40LG, F8, F3, MTHFR, F5, CFH
36cysteine448.0F3, CFH, MTHFR, F8, F5, CD40LG
37cardiolipin44 119.0F3, CD40LG, F5, CFH, APOH, F8
38vegf448.0CD40LG, F8, F5, SERPINE1, APOH, F3
39cholesterol44 28 24 1110.8F8, CFH, APOH, F5, SERPINE1, MTHFR
40homocysteine44 248.8F5, F8, MTHFR, F3, SERPINE1, APOH
41endotoxin447.7APOH, CD40LG, F8, F5, F3, ADAMTS13
42estrogen447.7CD40LG, F8, MTHFR, SERPINE1, APOH, F5
43retinoic acid44 248.7F3, CFH, F5, CD40LG, SERPINE1, MTHFR
44aspartate447.7SERPINE1, MTHFR, F3, CD40LG, F5, F8
45cyclophosphamide44 50 119.5F5, F8, MTHFR, F3, ADAMTS13, SERPINE1
46aspirin44 50 28 2410.4APOH, CD40LG, F5, MTHFR, F3, SERPINE1
47creatinine447.1MTHFR, F8, SERPINE1, ADAMTS13, F3, CD40LG
48serine446.7MTHFR, CD40LG, F8, CFH, SERPINE1, ADAMTS13
49fibrinogen446.5F5, F8, MTHFR, F3, PROC, ADAMTS13
50heparin44 28 24 119.5CD40LG, APOH, SERPINE1, ADAMTS13, PROC, F3

GO Terms for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Cellular components related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.9APOH, SERPINE1, F3
2platelet alpha granule lumenGO:0310938.7F5, F8, SERPINE1
3extracellular regionGO:0055768.0F5, F8, PROC, SERPINE1, CFH
4plasma membraneGO:0058867.0HLA-DRB4, SERPINE1, PROC, F3, F8, F5
5extracellular spaceGO:0056157.0CD40LG, CFH, APOH, SERPINE1, ADAMTS13, F3

Biological processes related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.4F8, APOH
2negative regulation of fibrinolysisGO:0519189.4APOH, SERPINE1
3blood circulationGO:0080159.3F5, MTHFR
4positive regulation of blood coagulationGO:0301949.3SERPINE1, APOH
5negative regulation of blood coagulationGO:0301959.2APOH, SERPINE1, PROC
6platelet degranulationGO:0025768.7F5, F8, SERPINE1
7platelet activationGO:0301688.2CD40LG, F5, F8, ADAMTS13, SERPINE1
8blood coagulationGO:0075968.1SERPINE1, PROC, F3, F8, F5

Molecular functions related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.2F5, F8, PROC
2protein bindingGO:0055156.4F5, HLA-DRB4, CFH, APOH, SERPINE1, ADAMTS13

Products for genes affiliated with Catastrophic Antiphospholipid Syndrome

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  • Antibodies
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Sources for Catastrophic Antiphospholipid Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet