MCID: CTS005
MIFTS: 45

Catastrophic Antiphospholipid Syndrome malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases categories

Summaries for Catastrophic Antiphospholipid Syndrome

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Wikipedia:63 Catastrophic antiphospholipid syndrome, CAPS, also known as Asherson?s syndrome, is an acute and complex... more...

MalaCards based summary: Catastrophic Antiphospholipid Syndrome, also known as thrombotic storm, is related to retinal artery occlusion and purpura. An important gene associated with Catastrophic Antiphospholipid Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Selected targets of HNF1 and Collagen biosynthesis and modifying enzymes. The compounds CL(20:4(8Z,11Z,14Z,17Z)/20:3(5Z,8Z,11Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related mouse phenotypes are nervous system and cardiovascular system.

Aliases & Classifications for Catastrophic Antiphospholipid Syndrome

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Catastrophic Antiphospholipid Syndrome, Aliases & Descriptions:

Name: Catastrophic Antiphospholipid Syndrome 41 60
Thrombotic Storm 41 20
 
Catastrophic Antiphospholipid Antibody Syndrome 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


Related Diseases for Catastrophic Antiphospholipid Syndrome

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Diseases related to Catastrophic Antiphospholipid Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1retinal artery occlusion31.1APOH
2purpura31.1ADAMTS13
3lupus erythematosus30.7CD40LG, F5, F3, APOH
4antiphospholipid syndrome30.6CD40LG, F5, F8, MTHFR, F3, ADAMTS13
5hemolytic anemia30.3CFH, APOH, ADAMTS13, F3
6systemic lupus erythematosus30.3CFH, APOH, ADAMTS13, F3, F8, CD40LG
7rheumatoid arthritis30.0CD40LG, MTHFR, APOH, HLA-DRB4
8pulmonary embolism29.9APOH, F3, MTHFR, F5
9thrombocytopenia29.8CFH, APOH, ADAMTS13, F3, F8, F5
10hellp syndrome29.6APOH, SERPINE1, ADAMTS13, MTHFR, F5
11disseminated intravascular coagulation29.5SERPINE1, ADAMTS13, PROC, F3, F8, F5
12protein s deficiency29.2F5, F8, MTHFR, F3, SERPINE1, APOH
13sneddon syndrome10.5APOH
14acute respiratory distress syndrome10.5
15syphilis10.5APOH
16pancreatitis10.4
17heparin-induced thrombocytopenia10.4
18hemorrhagic fever10.4CD40LG
19scrub typhus10.4CD40LG
20meningococcemia10.4F5
21cardiac tamponade10.4F8
22hepatitis a10.4F8
23sagittal sinus thrombosis10.4F5
24branch retinal artery occlusion10.4F5
25thrombotic thrombocytopenic purpura10.4CFH, ADAMTS13
26glomerulonephritis10.3
27acute interstitial pneumonia10.3
28polyarteritis nodosa10.3
29typhoid fever10.3
30endocarditis10.3
31pneumonia10.3
32retinitis10.3
33endotheliitis10.3
34cardiogenic shock10.3
35thrombotic thrombocytopenic purpura, familial10.3CFH, ADAMTS13
36thrombophlebitis10.3APOH, F8
37patent foramen ovale10.3F5
38cryoglobulinemia10.3APOH, CD40LG
39eclampsia10.3MTHFR
40raynaud disease10.3ADAMTS13, APOH
41hemolytic-uremic syndrome10.3CFH, ADAMTS13
42leukemia10.3
43splenic marginal zone lymphoma10.3
44calciphylaxis10.3
45acute myelomonocytic leukemia10.3
46pediatric systemic lupus erythematosus10.3
47mondor disease10.3APOH, F5
48hypoprothrombinemia10.3APOH, F5
49retinal vascular occlusion10.2APOH, F5
50lyme disease10.2CD40LG, CFH

Graphical network of the top 20 diseases related to Catastrophic Antiphospholipid Syndrome:



Diseases related to catastrophic antiphospholipid syndrome

Symptoms for Catastrophic Antiphospholipid Syndrome

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Drugs & Therapeutics for Catastrophic Antiphospholipid Syndrome

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Drug clinical trials:

Search ClinicalTrials for Catastrophic Antiphospholipid Syndrome

Search NIH Clinical Center for Catastrophic Antiphospholipid Syndrome

Genetic Tests for Catastrophic Antiphospholipid Syndrome

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Genetic tests related to Catastrophic Antiphospholipid Syndrome:

id Genetic test Affiliating Genes
1 Thrombotic Storm20

Anatomical Context for Catastrophic Antiphospholipid Syndrome

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MalaCards organs/tissues related to Catastrophic Antiphospholipid Syndrome:

31
Liver, Bone, Bone marrow, Heart, Skin, Endothelial, Lung, Breast

Animal Models for Catastrophic Antiphospholipid Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Catastrophic Antiphospholipid Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9CD40LG, F5, MTHFR, F3, PROC, CFH
2MP:00053857.6CFH, SERPINE1, PROC, F3, F5, CD40LG
3MP:00053977.5CFH, SERPINE1, ADAMTS13, PROC, F3, F8
4MP:00053877.4CFH, SERPINE1, ADAMTS13, PROC, F3, F8
5MP:00107717.4SERPINE1, F3, MTHFR, F5, CD40LG
6MP:00053766.2CD40LG, CFH, APOH, SERPINE1, ADAMTS13, PROC
7MP:00107686.1CFH, APOH, SERPINE1, ADAMTS13, PROC, F3

Publications for Catastrophic Antiphospholipid Syndrome

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Articles related to Catastrophic Antiphospholipid Syndrome:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Catastrophic antiphospholipid syndrome presenting as bilateral central retinal artery occlusions. (25722904)
2015
2
Multiple osteonecrotic lesions mimicking a piano keyboard in the spine of a patient with catastrophic antiphospholipid syndrome. (24838647)
2014
3
Catastrophic antiphospholipid syndrome and heparin-induced thrombocytopenia presenting with adrenal insufficiency caused by bilateral hemorrhagic adrenal infarction during sepsis. (24709482)
2014
4
A case of catastrophic antiphospholipid syndrome, which presented an acute interstitial pneumonia-like image on chest CT scan. (24533549)
2014
5
A case of catastrophic antiphospholipid syndrome, which presented an acute interstitial pneumonia-like image on chest CT scan. (23553659)
2013
6
Rituximab use in the catastrophic antiphospholipid syndrome: Descriptive analysis of the CAPS registry patients receiving rituximab. (23777822)
2013
7
Catastrophic antiphospholipid syndrome and pregnancy: an experience of 13 cases. (23676524)
2013
8
A 13-year-old girl with pancytopenia. Catastrophic antiphospholipid syndrome. (23556525)
2013
9
Catastrophic antiphospholipid syndrome with concurrent thrombotic and hemorrhagic manifestations. (23722230)
2013
10
The Hyperferritinemic Syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome. (23968282)
2013
11
Catastrophic antiphospholipid syndrome. (23278947)
2013
12
Vascular endothelial cell function in catastrophic antiphospholipid syndrome: a case report and review of the literature. (23762673)
2013
13
N2010 adult-onset Still's disease complicated by hemophagocytic syndrome and catastrophic antiphospholipid syndrome resulting in four limb amputation. (23781758)
2013
14
Relapsing catastrophic antiphospholipid syndrome potential role of microangiopathic hemolytic anemia in disease relapses. (22784445)
2013
15
Neurosurgical management for complicated catastrophic antiphospholipid syndrome. (24269552)
2013
16
8th International Congress on Autoimmunity: new perspectives for refractory catastrophic antiphospholipid syndrome. (23078059)
2012
17
Catastrophic antiphospholipid syndrome in a patient with V Leiden variant. (23319991)
2012
18
Severe abdominal pain as a presenting symptom of probable catastrophic antiphospholipid syndrome. (22711721)
2012
19
Multiple thromboemboli associated to two occult tumors: a case mimicking catastrophic antiphospholipid syndrome. (21459648)
2011
20
Eculizumab and renal transplantation in a patient with catastrophic antiphospholipid syndrome: effect of heparin on complement activation. (21335395)
2011
21
Catastrophic antiphospholipid syndrome (CAPS): update from the 'CAPS Registry'. (20353979)
2010
22
Reversible cardiac valvular disease in catastrophic antiphospholipid syndrome. (20508270)
2010
23
Infant with probable catastrophic antiphospholipid syndrome successfully managed with rituximab. (20478943)
2010
24
Catastrophic antiphospholipid syndrome complicated by cardiogenic shock - a case report]. (19650000)
2009
25
Massive cerebrovascular infarct due to the catastrophic antiphospholipid syndrome in a patient with idiopathic thrombocytopenic purpura. (19617232)
2009
26
Catastrophic antiphospholipid syndrome and rituximab: a new report]. (20187361)
2009
27
Catastrophic antiphospholipid syndrome: treatment, prognosis, and the risk of relapse. (19051065)
2009
28
Catastrophic antiphospholipid syndrome presenting as ischemic pancreatitis in systemic lupus erythematosus. (19734640)
2009
29
The catastrophic antiphospholipid syndrome in Serbia: diagnostic and management problems. (19048415)
2009
30
Catastrophic antiphospholipid syndrome in a patient with Down syndrome. (19762387)
2009
31
Relapsing catastrophic antiphospholipid syndrome: report of three cases. (17977582)
2008
32
A case of catastrophic antiphospholipid syndrome presenting with acute respiratory distress syndrome as the initial manifestation. (18651145)
2008
33
Reversible posterior leukoencephalopathy syndrome in catastrophic antiphospholipid syndrome. (17565204)
2007
34
Catastrophic antiphospholipid syndrome related to severe ovarian hyperstimulation. (16538387)
2007
35
Catastrophic antiphospholipid syndrome associated with malignancies (case report and review of the literature). (17283588)
2007
36
Severe limb necrosis: primary thrombotic microangiopathy or "seronegative" catastrophic antiphospholipid syndrome? A diagnostic dilemma. (17256103)
2007
37
Catastrophic antiphospholipid syndrome presenting with renal thrombotic microangiopathy and diffuse proliferative glomerulonephritis. (16539830)
2006
38
Catastrophic antiphospholipid syndrome: a rare cause of disseminated microvascular thrombotic injury - a case report with pathological and molecular correlative studies. (15743323)
2005
39
Refractory leg infection as an inducer of the catastrophic antiphospholipid syndrome. (15249331)
2004
40
Liver involvement in catastrophic antiphospholipid syndrome. (15168783)
2004
41
Combined plasmapheresis and immunosuppression as rescue treatment of a patient with catastrophic antiphospholipid syndrome occurring despite anticoagulation: a case report. (12945882)
2003
42
Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment. (17041346)
2002
43
Catastrophic antiphospholipid syndrome: clues to the pathogenesis from a series of 80 patients. (11704713)
2001
44
Catastrophic antiphospholipid syndrome. (10961585)
2000
45
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
46
Membranous obstruction of the inferior vena cava and extensive bone marrow necrosis associated with catastrophic antiphospholipid syndrome. (19078409)
1999
47
The pathogenesis of catastrophic antiphospholipid syndrome. (19078402)
1999
48
Anti beta 2-glycoprotein I antibodies in a patient with catastrophic antiphospholipid syndrome. (8608682)
1995
49
On the catastrophic antiphospholipid syndrome. A comment on the editorial by AlarcA^n-Segovia. (8070172)
1994
50
Catastrophic antiphospholipid syndrome (CAS): a rare manifestation of the antiphospholipid antibody syndrome. (8299260)
1993

Variations for Catastrophic Antiphospholipid Syndrome

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Expression for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Search GEO for disease gene expression data for Catastrophic Antiphospholipid Syndrome.

Pathways for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Compounds for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Compounds related to Catastrophic Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1CL(20:4(8Z,11Z,14Z,17Z)/20:3(5Z,8Z,11Z)/18:2(9Z,12Z)/18:2(9Z,12Z))249.8CRLS1, APOH
2ticlopidine43 1210.8F3, ADAMTS13, APOH
3CL(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z)/18:1(9Z)/18:1(9Z))249.8CRLS1, APOH
4CL(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z)/18:2(9Z,12Z))249.7CRLS1, APOH
5CL(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)/18:2(9Z,12Z)/18:2(9Z,12Z))249.7APOH, CRLS1
6CL(18:2(9Z,12Z)/18:2(9Z,12Z)/18:1(11Z)/16:1(9Z))249.7APOH, CRLS1
7coumarins439.6APOH, F3, F5
8gamma-carboxyglutamic acid439.6F3, PROC, F5
9CL(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))249.6APOH, CRLS1
10anisodamine439.5F3, SERPINE1
11cacl2439.4F5, F8, F3
12rituximab43 49 1211.4F8, APOH, CD40LG, ADAMTS13
13fluorescein43 1210.4CD40LG, F5, F3
14phosphatidylethanolamine43 1210.4APOH, F8, F5
15CL(18:2(9Z,12Z)/18:2(9Z,12Z)/18:1(11Z)/18:1(11Z))249.4APOH, CRLS1
16dextran sulfate439.3F3, F5, APOH, CD40LG
17kaolin439.2F8, APOH, F3, F5
18ristocetin439.2F8, F3, ADAMTS13, F5
19tranexamic acid43 1210.2SERPINE1, F3, F8
20vitamin b12439.1CD40LG, F5, MTHFR, APOH
21nacl439.0F5, CFH, ADAMTS13, F8
22folate439.0F5, APOH, MTHFR, CD40LG
23p00001438.9F8, MTHFR, SERPINE1
24phospholipid438.9F8, PROC, F5, F3, APOH
25phosphatidylserine43 28 1210.8F8, CD40LG, F5, APOH, F3
26kininogen438.8F3, SERPINE1, APOH, F5
27polysaccharide438.8CFH, F3, F8, F5, CD40LG
28cyclosporin a43 28 5910.7CD40LG, CFH, F8, ADAMTS13, MTHFR
29tacrolimus43 49 1210.6SERPINE1, F3, CFH, F5
30uric acid43 249.6F5, APOH, MTHFR, SERPINE1
31prostacyclin438.4APOH, F5, SERPINE1, F3, F8
32desmopressin43 59 28 1211.4F5, F3, ADAMTS13, SERPINE1, F8
33warfarin43 49 24 1211.3F5, MTHFR, PROC, APOH, F8, F3
34hirudin438.3SERPINE1, F3, F5, CD40LG, F8
35alanine438.1CD40LG, F8, F3, MTHFR, F5, CFH
36cysteine438.0F3, CFH, MTHFR, F8, F5, CD40LG
37cardiolipin43 129.0F3, CD40LG, F5, CFH, APOH, F8
38vegf438.0CD40LG, F8, F5, SERPINE1, APOH, F3
39cholesterol43 28 24 1210.8F8, CFH, APOH, F5, SERPINE1, MTHFR
40homocysteine43 248.8F5, F8, MTHFR, F3, SERPINE1, APOH
41endotoxin437.7APOH, CD40LG, F8, F5, F3, ADAMTS13
42estrogen437.7CD40LG, F8, MTHFR, SERPINE1, APOH, F5
43retinoic acid43 248.7F3, CFH, F5, CD40LG, SERPINE1, MTHFR
44aspartate437.7SERPINE1, MTHFR, F3, CD40LG, F5, F8
45cyclophosphamide43 49 129.5F5, F8, MTHFR, F3, ADAMTS13, SERPINE1
46aspirin43 49 28 2410.4APOH, CD40LG, F5, MTHFR, F3, SERPINE1
47creatinine437.1MTHFR, F8, SERPINE1, ADAMTS13, F3, CD40LG
48serine436.7MTHFR, CD40LG, F8, CFH, SERPINE1, ADAMTS13
49fibrinogen436.5F5, F8, MTHFR, F3, PROC, ADAMTS13
50heparin43 28 24 129.5CD40LG, APOH, SERPINE1, ADAMTS13, PROC, F3

GO Terms for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Cellular components related to Catastrophic Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.9APOH, SERPINE1, F3
2platelet alpha granule lumenGO:00310938.7F5, F8, SERPINE1
3extracellular regionGO:00055768.0F5, F8, PROC, SERPINE1, CFH
4plasma membraneGO:00058867.0HLA-DRB4, SERPINE1, PROC, F3, F8, F5
5extracellular spaceGO:00056157.0CD40LG, CFH, APOH, SERPINE1, ADAMTS13, F3

Biological processes related to Catastrophic Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00075979.4F8, APOH
2negative regulation of fibrinolysisGO:00519189.4APOH, SERPINE1
3blood circulationGO:00080159.3F5, MTHFR
4positive regulation of blood coagulationGO:00301949.3SERPINE1, APOH
5negative regulation of blood coagulationGO:00301959.2APOH, SERPINE1, PROC
6platelet degranulationGO:00025768.7F5, F8, SERPINE1
7platelet activationGO:00301688.2CD40LG, F5, F8, ADAMTS13, SERPINE1
8blood coagulationGO:00075968.1SERPINE1, PROC, F3, F8, F5

Molecular functions related to Catastrophic Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.2F5, F8, PROC
2protein bindingGO:00055156.4F5, HLA-DRB4, CFH, APOH, SERPINE1, ADAMTS13

Products for genes affiliated with Catastrophic Antiphospholipid Syndrome

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Sources for Catastrophic Antiphospholipid Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet