MCID: CTS005
MIFTS: 35

Catastrophic Antiphospholipid Syndrome malady

Immune diseases, Blood diseases categories

Summaries for Catastrophic Antiphospholipid Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Catastrophic antiphospholipid syndrome, CAPS, also known as Asherson’s syndrome, is an acute and... more...

MalaCards: Catastrophic Antiphospholipid Syndrome, also known as thrombotic storm, is related to antiphospholipid syndrome and lupus erythematosus. An important gene associated with Catastrophic Antiphospholipid Syndrome is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Selected targets of HNF1. The compounds warfarin and serine have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Catastrophic Antiphospholipid Syndrome

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42NIH Rare Diseases, 20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

catastrophic antiphospholipid syndrome 42
thrombotic storm 42 20
catastrophic antiphospholipid antibody syndrome 42


Related Diseases for Catastrophic Antiphospholipid Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Catastrophic Antiphospholipid Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1antiphospholipid syndrome31.9APOH, F8, F5, ADAMTS13, CFH, F3
2lupus erythematosus30.7APOH, F5, F3, CD40LG
3systemic lupus erythematosus30.7CD40LG, APOH, F8, F3, ADAMTS13, CFH
4glomerulonephritis30.4CFH, CD40LG
5acute leukemia30.3MTHFR
6leukemia30.3F8, MTHFR, CD40LG
7purpura30.2ADAMTS13
8ovarian hyperstimulation syndrome30.2F5
9hepatitis30.2F8, CD40LG
10down syndrome30.2MTHFR
11coronary thrombosis30.2SERPINE1, F3
12rheumatoid arthritis30.2CD40LG, MTHFR, APOH, HLA-DRB4
13hypertension30.2MTHFR, F5, SERPINE1
14hemolytic anemia30.2F3, ADAMTS13, CFH, APOH
15pulmonary embolism30.2MTHFR, F3, APOH, F5
16hellp syndrome30.2F5, MTHFR, SERPINE1, ADAMTS13, APOH
17disseminated intravascular coagulation30.2SERPINE1, F8, F5, PROC, F3, ADAMTS13
18thrombocytopenia30.1F8, APOH, F5, CD40LG, F3, CFH
19protein s deficiency30.1SERPINE1, F8, F3, F5, APOH, MTHFR
20pancreatitis10.4
21polyarteritis nodosa10.3
22adult syndrome10.3
23typhoid fever10.3
24endocarditis10.3
25image syndrome10.3
26splenic marginal zone lymphoma10.3
27childhood leukemia10.3
28graft versus host disease10.1
29crescentic glomerulonephritis10.1
30acute interstitial pneumonia10.1
31acute chest syndrome10.1
32choroiditis10.1
33adult respiratory distress syndrome10.1
34cerebritis10.1
35proliferative glomerulonephritis10.1
36pancytopenia10.1
37adult-onset still's disease10.1
38sclerosing cholangitis10.1
39n syndrome10.1
40invasive aspergillosis10.1
41arthritis10.1
42aspergillosis10.1
43cholangitis10.1
44diffuse glomerulonephritis10.1
45dilated cardiomyopathy10.1
46herpes simplex10.1
47influenza10.1
48pneumonia10.1
49retinitis10.1
50kimura disease10.1

Graphical network of the top 20 diseases related to Catastrophic Antiphospholipid Syndrome:



Diseases related to catastrophic antiphospholipid syndrome

Clinical Features for Catastrophic Antiphospholipid Syndrome

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Drugs & Therapeutics for Catastrophic Antiphospholipid Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Catastrophic Antiphospholipid Syndrome

Genetic Tests for Catastrophic Antiphospholipid Syndrome

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20GeneTests
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Genetic tests related to Catastrophic Antiphospholipid Syndrome:

id Genetic test Affiliating Genes
1 Thrombotic Storm20

Anatomical Context for Catastrophic Antiphospholipid Syndrome

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Animal Models for Catastrophic Antiphospholipid Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Catastrophic Antiphospholipid Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.1CFH, F3, CD40LG
2MP:00053977.5F8, PROC, CD40LG, F3, CFH, SERPINE1
3MP:00053877.3F8, PROC, CD40LG, F3, CFH, SERPINE1
4MP:00053766.1ADAMTS13, APOH, F8, F5, MTHFR, PROC
5MP:00107686.0APOH, F8, F5, MTHFR, PROC, CD40LG

Publications for Catastrophic Antiphospholipid Syndrome

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Genetic Variations for Catastrophic Antiphospholipid Syndrome

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Expression for genes affiliated with Catastrophic Antiphospholipid Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Catastrophic Antiphospholipid Syndrome

Search GEO for disease gene expression data for Catastrophic Antiphospholipid Syndrome.

Pathways for genes affiliated with Catastrophic Antiphospholipid Syndrome

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53Reactome, 49PharmGKB, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Compounds for genes affiliated with Catastrophic Antiphospholipid Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.4APOH, PROC
2serine4410.2F8, ADAMTS13
3aspartate4410.1F8, CD40LG
4cardiolipin44 1111.1CRLS1, CFH
5coumarins4410.0APOH, F3
6fluorescein44 1110.7F3, CD40LG
7anisodamine449.7SERPINE1, F3
8ticlopidine44 1110.6ADAMTS13, F3, APOH
9phosphatidylserine44 28 1111.6APOH, F8, F3
10rituximab44 49 1111.5CD40LG, APOH, ADAMTS13, F8
11ivig449.4APOH, F8, CD40LG
12dextran sulfate449.4F5, CD40LG, APOH
13p00001449.4F8, SERPINE1, MTHFR
14tranexamic acid44 1110.4SERPINE1, F8, F3
15phosphatidylethanolamine44 1110.2APOH, F5, F8
16Drotrecogin alfa119.2F8, F5, SERPINE1
17inogatran449.1F5, F3
18gamma-carboxyglutamic acid449.1PROC, F5, F3
19heparin44 28 11 2412.0CD40LG, MTHFR, ADAMTS13, F8, APOH
20cacl2449.0F8, F5, F3
21mycophenolate mofetil44 49 1111.0SERPINE1, CD40LG, F5
22ecarin448.9F5, F3
23vitamin b12448.9APOH, CD40LG, MTHFR, F5
24cyclosporin a44 28 5910.8MTHFR, CD40LG, F8, CFH, ADAMTS13
25kaolin448.8F8, APOH, F5, F3
26uric acid44 249.8MTHFR, SERPINE1, F5, APOH
27nacl448.8F5, ADAMTS13, CFH, F8
28folate448.8MTHFR, CD40LG, F5, APOH
29ristocetin448.7ADAMTS13, F8, F5, F3
30kininogen448.7F3, SERPINE1, F5, APOH
31protamine448.7SERPINE1, F5, F3
32metformin44 49 1110.7F5, SERPINE1, MTHFR
33phospholipid448.4APOH, F8, F3, PROC, F5
34prostacyclin448.3F3, F5, F8, APOH, SERPINE1
35desmopressin44 59 28 1111.3F8, ADAMTS13, F5, SERPINE1, F3
36polysaccharide448.3F3, F8, F5, CD40LG, CFH
37hirudin448.2F5, SERPINE1, F3, CD40LG, F8
38cholesterol44 28 11 2411.0F8, MTHFR, CFH, SERPINE1, APOH, F5
39epinephrine44 11 249.9F3, CD40LG, F8, F5
40estrogen447.9F8, F5, MTHFR, CD40LG, SERPINE1, APOH
41vegf447.9SERPINE1, F3, CD40LG, F5, F8, APOH
42homocysteine44 248.8APOH, F8, SERPINE1, F3, MTHFR, F5
43alanine447.7F8, F5, MTHFR, CD40LG, CFH, F3
44endotoxin447.6F5, APOH, F8, CD40LG, F3, SERPINE1
45cysteine447.6F5, CD40LG, F8, MTHFR, CFH, F3
46retinoic acid44 248.6SERPINE1, CFH, CD40LG, MTHFR, F5, F3
47cyclophosphamide44 49 119.5SERPINE1, ADAMTS13, F3, MTHFR, F5, F8
48aspirin44 49 28 2410.4F5, SERPINE1, F3, APOH, F8, MTHFR
49creatinine447.1F5, ADAMTS13, APOH, F3, CD40LG, MTHFR
50fibrinogen446.5F8, SERPINE1, F5, ADAMTS13, CFH, F3

GO Terms for genes affiliated with Catastrophic Antiphospholipid Syndrome

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16Gene Ontology
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Cellular components related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, F3, APOH
2platelet alpha granule lumenGO:0310938.5SERPINE1, F5, F8
3extracellular spaceGO:0056156.8ADAMTS13, APOH, F8, F5, CD40LG, F3

Biological processes related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.8F8, APOH
2negative regulation of fibrinolysisGO:0519189.7APOH, SERPINE1
3negative regulation of blood coagulationGO:0301959.6APOH, PROC, SERPINE1
4positive regulation of blood coagulationGO:0301949.5SERPINE1, APOH
5platelet degranulationGO:0025768.8SERPINE1, F5, F8
6platelet activationGO:0301688.2ADAMTS13, SERPINE1, CD40LG, F5, F8
7blood coagulationGO:0075967.9F8, F5, PROC, F3, SERPINE1

Molecular functions related to Catastrophic Antiphospholipid Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6ADAMTS13, SERPINE1, CFH, F3, PROC, F5

Products for genes affiliated with Catastrophic Antiphospholipid Syndrome

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  • Antibodies
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Sources for Catastrophic Antiphospholipid Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet