MCID: CDQ001
MIFTS: 41

Cauda Equina Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

MalaCards integrated aliases for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 49 14 69
Polyradiculopathy 41 69
Cauda Equina 51

Classifications:



External Ids:

Disease Ontology 12 DOID:11577
ICD10 32 G83.4
ICD9CM 34 344.6
MeSH 41 D011128
NCIt 46 C35436
UMLS 69 C0392548

Summaries for Cauda Equina Syndrome

NIH Rare Diseases : 49 Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. Signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; "foot drop"; problems with bowel and/or bladder control; and sexual dysfunction. Cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. Treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. Physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. Last updated: 5/17/2015

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma. An important gene associated with Cauda Equina Syndrome is NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1), and among its related pathways/superpathways is Adipogenesis. The drugs Chloroprocaine and Procaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, b cells and bone, and related phenotype is limbs/digits/tail.

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 72 Cauda equina syndrome (CES) is symptoms due to damage to the bundle of nerves below the end of the... more...

Related Diseases for Cauda Equina Syndrome

Diseases related to Cauda Equina Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 cauda equina neoplasm 12.6
2 cauda equina intradural extramedullary astrocytoma 12.3
3 polyradiculopathy 12.2
4 spinal disease 11.2
5 inflammatory spondylopathy 10.6
6 spondylitis 10.6
7 spondyloarthropathy 1 10.6
8 lymphoma 10.4
9 arachnoiditis 10.4
10 episodic pain syndrome, familial, 1 10.3
11 spinal stenosis 10.3
12 meningitis 10.2
13 epidural abscess 10.2
14 lipomatosis 10.2
15 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.2
16 b-cell lymphomas 10.2
17 thrombosis 10.2
18 arachnoid cysts 10.2
19 ependymoma 10.2
20 back pain 10.2
21 leukemia 10.1
22 sarcoma 10.1
23 aneurysm 10.1
24 spinal arachnoiditis 10.1
25 spondylolisthesis 10.1
26 hydrocephalus 10.1
27 radiculopathy 10.1
28 peroneal nerve paralysis 10.0 ALDH5A1 PMP22
29 aortic aneurysm, familial abdominal, 1 10.0
30 lipomatosis, multiple 10.0
31 small cell cancer of the lung 10.0
32 lung cancer 10.0
33 chordoma 10.0
34 body mass index quantitative trait locus 11 10.0
35 aging 10.0
36 body mass index quantitative trait locus 9 10.0
37 body mass index quantitative trait locus 8 10.0
38 body mass index quantitative trait locus 7 10.0
39 body mass index quantitative trait locus 12 10.0
40 body mass index quantitative trait locus 14 10.0
41 body mass index quantitative trait locus 18 10.0
42 arteriovenous fistula 10.0
43 hemangioma 10.0
44 meningocele 10.0
45 arteriovenous malformation 10.0
46 cervicitis 10.0
47 myelitis 10.0
48 aortic aneurysm 10.0
49 myxopapillary ependymoma 10.0
50 paget's disease of bone 10.0

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

MGI Mouse Phenotypes related to Cauda Equina Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 BMP2 EGR2 NR1D1 PMP22

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chloroprocaine Approved 133-16-4 8612
2
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
3 Anesthetics
4 Anesthetics, Local
5 Central Nervous System Depressants
6 Peripheral Nervous System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
2 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056
3 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
4 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
5 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
6 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Not yet recruiting NCT02806167

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

38
Spinal Cord, B Cells, Bone, Breast, Lung, T Cells, Myeloid

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 552)
# Title Authors Year
1
Time Factor and Disc Herniation Size: Are They Really Predictive for Outcome of Urinary Dysfunction in Patients With Cauda Equina Syndrome? ( 29425362 )
2018
2
Outcomes reported after surgery for Cauda Equina Syndrome: A Systematic Literature Review. ( 29432394 )
2018
3
Neurological recovery after traumatic Cauda Equina syndrome due to glass fragments: An unusual case. ( 29350375 )
2018
4
Epidemiology of cauda equina syndrome. What changed until 2015. ( 29367915 )
2018
5
Elsberg syndrome: A rarely recognized cause of cauda equina syndrome and lower thoracic myelitis. ( 28534040 )
2017
6
Acute flaccid paraparesis (cauda equina syndrome) in a patient with Bardet-Biedl syndrome. ( 28566787 )
2017
7
Unusual cauda equina syndrome due to multifocal ependymoma infiltrated by lymphoma. ( 29354750 )
2017
8
Cauda Equina Syndrome in a Lactating Mother - A Safe Treatment Approach. ( 28969225 )
2017
9
Neurosurgeon or spinal surgeon - who should treat cauda equina syndrome? ( 28637116 )
2017
10
Anterior lumbar discectomy and fusion for acute cauda equina syndrome caused by recurrent disc prolapse: report of 3 cases. ( 28708040 )
2017
11
Prediction of the outcome of bladder dysfunction based on electrically induced reflex findings in patients with cauda equina syndrome: A retrospective study. ( 28538420 )
2017
12
Definitions of traumatic conus medullaris and cauda equina syndrome: a systematic literature review. ( 28534496 )
2017
13
Leptomeningeal Carcinomatosis Presenting as Cauda Equina Syndrome. ( 28904471 )
2017
14
Persistent cauda equina syndrome after caudal epidural injection under severe spinal stenosis: a case report. ( 28652808 )
2017
15
Misplacement of Stent Into Epidural Venous Plexus With Resultant Cauda Equina Syndrome and Open Surgical Treatment: A Case Report. ( 29211872 )
2017
16
Dengue fever presenting as cauda equina syndrome. ( 28739570 )
2017
17
A Good Short-term Outcome in Delayed Decompression of Cauda Equina Syndrome in<i>Klebsiella pneumoniae</i>Spinal Epidural Abscess: A Case Report. ( 29021888 )
2017
18
Incomplete cauda equina syndrome secondary to haemorrhage within a Tarlov cyst. ( 28784878 )
2017
19
Cauda equina syndrome caused by filum terminale lipoma: magnetic resonance imaging features and surgical treatment. ( 28444101 )
2017
20
Cauda Equina Syndrome Due To Dural Sac Shift with Engorgement of the Epidural Venous Plexus: Rare Complication After Lumbar Microdiscectomy. ( 28546122 )
2017
21
Neisseria meningitidis subdural empyema causing acute cauda equina syndrome. ( 28653638 )
2017
22
Cauda Equina Syndrome Due to Lumbar Disc Herniation: a Review of Literature. ( 29341941 )
2017
23
Analysis of clinical and neurological outcomes in patients with cauda equina syndrome caused by acute lumbar disc herniation: a retrospective-prospective study. ( 29137416 )
2017
24
Early cauda equina syndrome (CESE). ( 28478686 )
2017
25
Cauda Equina Syndrome Due to Vigorous Back Massage With Spinal Manipulation in a Patient With Pre-Existing Lumbar Disc Herniation: A Case Report and Literature Review. ( 28796647 )
2017
26
Lumbar spinal canal MRI diameter is smaller in herniated disc cauda equina syndrome patients. ( 29023556 )
2017
27
Guidelines for cauda equina syndrome. Red flags and white flags. Systematic review and implications for triage. ( 28637110 )
2017
28
Editorial. Use of anterior lumbar discectomy and interbody fusion in the management of recurrent lumbar disc herniation and cauda equina syndrome. ( 28708042 )
2017
29
The lived experience of Cauda Equina Syndrome: a qualitative analysis. ( 28786413 )
2017
30
Erratum: Against the odds: extraordinary recovery from complete cauda equina syndrome following L3 fracture. Time still matters. ( 28503318 )
2017
31
Contained ruptured abdominal aortic aneurysm presenting as cauda equina syndrome. ( 28062419 )
2017
32
Conus Medullaris Arachnoid Cyst Presenting as Cauda Equina Syndrome. ( 29114289 )
2017
33
Obesity and spinal epidural lipomatosis in cauda equina syndrome. ( 28756300 )
2017
34
Impact of MR Neurography in Patients with Chronic Cauda Equina Syndrome Presenting as Chronic Pelvic Pain and Dysfunction. ( 28059708 )
2016
35
18F-FDG PET/CT Imaging of Cauda Equina Syndrome Secondary to Leptomeningeal Metastatic Breast Cancer. ( 27607169 )
2016
36
Erratum: Management of neglected sacral fracture with cauda equina syndrome: report of two cases with review of literature. ( 28067337 )
2016
37
Comment on "Cauda equina syndrome: an uncommon cause of urinary retention in a young woman". ( 27525689 )
2016
38
Does Early Surgical Decompression in Cauda Equina Syndrome Improve Bladder Outcome?: Comments on a Recent Study by Srikandarajah et al. ( 27831995 )
2016
39
Poster 227 Cauda Equina Syndrome after Lumbar Disk Herniation: A Case Report. ( 27672986 )
2016
40
Cauda equina syndrome. An emergency, some unexpected severe symptoms and conservative treatment. ( 27999827 )
2016
41
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
42
Doing More with Less: Diagnostic Accuracy of CT in Suspected Cauda Equina Syndrome. ( 27789449 )
2016
43
Post-hemorrhagic hydrocephalus presenting as cauda equina syndrome in a patient with spinal dysraphism. ( 26675625 )
2016
44
Brucellar spondylodiscitis with rapidly progressive spinal epidural abscess showing cauda equina syndrome. ( 28053732 )
2016
45
Intramedullary Abscess by Staphylococcus aureus Presenting as Cauda Equina Syndrome to the Emergency Department. ( 27293918 )
2016
46
Differential diagnosis and treatment of acute cauda equina syndrome in the human immunodeficiency virus positive patient: a case report and review of the literature. ( 27268102 )
2016
47
Spontaneous Hemorrhage of a Spinal Ependymoma in the Filum Terminale Presenting with Acute Cauda Equina Syndrome: Case Report. ( 28664006 )
2016
48
Cauda Equina Syndrome Secondary to Leptomeningeal Carcinomatosis of Gastroesophageal Junction Cancer. ( 27239185 )
2016
49
Examination of The Predictive Power of Electromyography and Urodynamic Study in Patients with Cauda Equina Syndrome (Horse Tail Syndrome). ( 28077887 )
2016
50
Posterior Epidural Migration of a Sequestrated Lumbar Disk Fragment Causing Cauda Equina Syndrome in an Old Patient: A Case Report. ( 27257401 )
2016

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.74 BMP2 EGR2

GO Terms for Cauda Equina Syndrome

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.43 BMP2 EGR2 NR1D1
2 myelination GO:0042552 9.16 EGR2 PMP22
3 peripheral nervous system development GO:0007422 8.96 EGR2 PMP22
4 respiratory electron transport chain GO:0022904 8.62 ALDH5A1 MT-CO3

Sources for Cauda Equina Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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