MCID: CDQ001
MIFTS: 40

Cauda Equina Syndrome malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Cauda Equina Syndrome

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Aliases & Descriptions for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 10 45 12 65
Polyradiculopathy 36
 
Cauda Equina 47


Classifications:



External Ids:

Disease Ontology10 DOID:11577
ICD9CM29 344.6
MeSH36 D011128
NCIt42 C35436
ICD1027 G83.4

Summaries for Cauda Equina Syndrome

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NIH Rare Diseases:45 Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; "foot drop"; problems with bowel and/or bladder control; and sexual dysfunction. cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. last updated: 5/17/2015

MalaCards based summary: Cauda Equina Syndrome, also known as polyradiculopathy, is related to spondylitis and polyradiculopathy. An important gene associated with Cauda Equina Syndrome is EGR2 (Early Growth Response 2), and among its related pathways are Adipogenesis and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include spinal cord, bone and b cells, and related mouse phenotypes are skeleton and hearing/vestibular/ear.

Disease Ontology:10 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia:68 Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes... more...

Related Diseases for Cauda Equina Syndrome

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Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to cauda equina syndrome

Symptoms for Cauda Equina Syndrome

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Drugs & Therapeutics for Cauda Equina Syndrome

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Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Procaineapproved, investigational2859-46-14914
Synonyms:
.beta.-(Diethylamino)ethyl p-aminobenzoate
.beta.-Diethylaminoethyl 4-aminobenzoate
2-(Diethylamino)ethyl 4-aminobenzoate
2-(Diethylamino)ethyl p-aminobenzoate
2-(Diethylamino)ethyl-4-aminobenzoate
2-Diethylaminoethyl 4-aminobenzoate
2-Diethylaminoethyl p-aminobenzoate
2-Diethylaminoethylester kyseliny p-aminobenzoove
2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]
4-14-00-01138 (Beilstein Handbook Reference)
4-Aminobenzoesaeure-beta-diethylaminoethylester
4-Aminobenzoic acid 2-(diethylamino) ethyl ester
4-Aminobenzoic acid 2-diethylaminoethyl ester
4-Aminobenzoic acid diethylaminoethyl ester
59-46-1
91484-72-9
AB00053531
AC1L1J8C
AC1Q2ZE2
AKOS000115407
Allocaine
Anticort
Anticort (TM)
Anuject
BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE
BPBio1_000179
BRD-K24616672-003-05-2
BRN 0913480
BSPBio_000161
BSPBio_002231
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester
Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
C07375
CAS-51-05-8
CHEBI:8430
CHEMBL569
CID4914
D08422
DB00721
Diethylaminoethyl p-aminobenzoate
DivK1c_000120
Duracaine
EINECS 200-426-9
Factor H3
Gerokit
Gerovital
Gerovital H-3
HSDB 3388
I06-1439
IDI1_000120
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
Jenacain
Jenacaine
KBio1_000120
KBio2_001318
KBio2_003886
KBio2_006454
KBio3_001731
KBioGR_000975
 
KBioSS_001318
LS-35778
Lopac-P-9879
Lopac0_000966
MolPort-000-889-177
NCGC00015864-01
NCGC00015864-02
NCGC00015864-04
NCGC00162298-01
NINDS_000120
NSC 169497
NSC169497
Nissocaine
Norocaine
Novocain
Novocaine
Prestwick0_000041
Prestwick1_000041
Prestwick2_000041
Prestwick3_000041
Procain
Procaina
Procaina [INN-Spanish]
Procaine
Procaine (INN)
Procaine HCl
Procaine Hydrochloride
Procaine [INN:BAN]
Procaine, base
Procainum
Procainum [INN-Latin]
SP-01A
SP01
SP01A
SPBio_001331
SPBio_002082
STK177303
STOCK2S-12721
Scurocaine
Solution of novocain
Solution of novocain (TN)
Spectrum2_001296
Spectrum3_000556
Spectrum4_000488
Spectrum5_001186
Spectrum_000838
Spinocaine
Stoff H3
UNII-4Z8Y51M438
Vitamin H3
WLN: ZR DVO2N2&2
beta-(Diethylamino)ethyl 4-aminobenzoate
beta-(Diethylamino)ethyl P-aminobenzoate
beta-(Diethylamino)ethyl p-aminobenzoate
beta-Diethylaminoethyl 4-aminobenzoate
p-Aminobenzoic acid 2-diethylaminoethyl ester
p-Aminobenzoyldiethylaminoethanol
p-Aminobenzyoyldiethylaminoethanol
procaine
╬▓-(diethylamino)ethyl 4-aminobenzoate
╬▓-(diethylamino)ethyl p-aminobenzoate
2
Chloroprocaineapproved14133-16-48612
Synonyms:
133-16-4
2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate
2-(Diethylaminoethyl)-4-amino-2-chlorobenzoate
2-Chloroprocaine
2-diethylaminoethyl 4-amino-2-chlorobenzoate
3858-89-7 (hydrochloride)
4-14-00-01273 (Beilstein Handbook Reference)
4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester
4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
AC1L1RCM
BRN 2808071
Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester
C07877
C13H19ClN2O2
CHEBI:3636
CHLOROPROCAINE
CID8612
Chlor-procaine
Chloroprocain
 
Chloroprocaine
Chloroprocaine (INN)
Chloroprocaine Hydrochloride
Chloroprocaine [INN]
Chloroprocaine hydrochloride
Chloroprocainum
Chloroprocainum [INN-Latin]
Chlorprocaine
Chlorprocainum
Cloroprocaina
Cloroprocaina [INN-Spanish]
D07678
DB01161
HSDB 3301
Halestyn
LS-35706
Nesacaine
Nesacaine MPF
Nesacaine-Ce
Piocaine
UNII-5YVB0POT2H

Interventional clinical trials:

idNameStatusNCT IDPhase
1Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)Not yet recruitingNCT02591901Phase 2
2Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal AnaesthesiaRecruitingNCT02067806
3Peristeen Bowel Irrigation System in Cauda EquinaActive, not recruitingNCT01784328
4Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated DiscEnrolling by invitationNCT00927056

Search NIH Clinical Center for Cauda Equina Syndrome


Cochrane evidence based reviews: Polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

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Anatomical Context for Cauda Equina Syndrome

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MalaCards organs/tissues related to Cauda Equina Syndrome:

33
Spinal cord, Bone, B cells, Lung, Breast, T cells, Pituitary

Animal Models for Cauda Equina Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Cauda Equina Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6ANKRD11, BMP2, EGR2, FOS
2MP:00053778.5BMP2, EGR2, FOS, PMP22
3MP:00053828.5ANKRD11, BMP2, EGR2, FOS
4MP:00053718.5BMP2, EGR2, FOS, PMP22
5MP:00053808.3ANKRD11, BMP2, EGR2, FOS
6MP:00053898.3BMP2, EGR2, FOS, PMP22
7MP:00053918.1ANKRD11, EGR2, FOS, PMP22
8MP:00053787.4ANKRD11, BMP2, EGR2, FOS, PMP22

Publications for Cauda Equina Syndrome

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Articles related to Cauda Equina Syndrome:

(show top 50)    (show all 472)
idTitleAuthorsYear
1
Cauda equina syndrome: is the current management of patients presenting to district general hospitals fit for purpose? A personal view based on a review of the literature and a medicolegal experience. (26430015)
2015
2
An acute bleeding metastatic spinal tumor from HCC causes an acute onset of cauda equina syndrome. (26298047)
2015
3
Giant malignant peripheral nerve sheath tumor with cauda equina syndrome and subarachnoid hemorrhage: Complications in a case of type 1 neurofibromatosis. (26283846)
2015
4
Neurological deterioration in cauda equina syndrome is probably progressive and continuous. Implications for clinical management. (26401618)
2015
5
Cauda equina syndrome caused by a spontaneous spinal haematoma. (26123457)
2015
6
ACUTE CAUDA EQUINA SYNDROME CAUSED BY A DISK LESION: IS EMERGENT SURGERY THE CORRECT OPTION? (25608248)
2015
7
Cauda equina syndrome due to intravascular lymphoma: diagnosis by nasal biopsy. (25717092)
2015
8
Cauda Equina Syndrome in a 36 Week Gravida Patient. (26394499)
2015
9
The accuracy of clinical symptoms in detecting cauda equina syndrome in patients undergoing acute MRI of the spine. (26306934)
2015
10
Neoplastic cauda equina syndrome: a neuroimaging-based review. (26442520)
2015
11
Cauda equina syndrome: evaluation of the clinical outcome. (24763893)
2014
12
Cauda equina syndrome: implications for primary care. (24567588)
2014
13
Why not decompress early? The cauda equina syndrome. (24631648)
2014
14
Foix-alajouanine syndrome presenting as acute cauda equina syndrome: a case report. (25396108)
2014
15
A case of cauda equina syndrome in early-onset chronic inflammatory demyelinating polyneuropathy clinically similar to charcot-marie-tooth disease type 1. (25237436)
2014
16
Cauda equina syndrome secondary to intradural renal cell carcinoma metastasis haemorrhage. (22985045)
2013
17
Cauda equina syndrome after a TLIF resulting from postoperative expansion of a hydrogel dural sealant. (21952743)
2012
18
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. (23084725)
2012
19
Cauda equina syndrome after spinal anaesthesia in a patient with asymptomatic tubercular arachnoiditis. (22013254)
2011
20
Is cauda equina syndrome being treated within the recommended time frame? (21311382)
2011
21
Lumboperitoneal shunting of cerebrospinal fluid versus anti-tumor necrosis factor treatment of cauda equina syndrome in ankylosing spondylitis: comment on the article by Cornec et al. (20178129)
2010
22
Cauda Equina Syndrome. (19711885)
2009
23
Cauda equina syndrome caused by a complete traumatic lumbar disc complex extrusion without alterations of facet joints. (19910776)
2009
24
Cauda equina syndrome: A rare complication in intensive care. (19838356)
2009
25
Cauda equina syndrome presentation of sacral insufficiency fractures. (17177021)
2007
26
Cauda equina syndrome as a rare manifestation of leukemia relapse during postallograft period. (16749661)
2006
27
Postoperative cauda equina syndrome in patients undergoing single-level lumbar microdiscectomy. Report of two cases. (16122210)
2005
28
Posterior epidural migration of sequestered lumbar disc fragment causing cauda equina syndrome. (16482671)
2005
29
Cauda equina syndrome as a postoperative complication of lumbar spine surgery. (15202877)
2004
30
The irreplaceable image: Leptomeningeal leukemia masquerading as cauda equina syndrome: appraisal by magnetic resonance imaging. (11602427)
2001
31
Cauda equina syndrome. (11311464)
2001
32
Cauda equina syndrome as a postoperative complication in five patients operated for lumbar disc herniation. (11224866)
2001
33
Lumbar pannus presenting as cauda equina syndrome in a patient with longstanding rheumatoid arthritis. (11296971)
2001
34
Cauda equina syndrome secondary to idiopathic spinal epidural lipomatosis. (11224868)
2001
35
Hydroxyurea therapy in paraparesis and cauda equina syndrome due to extramedullary haematopoiesis in thalassaemia: improvement of clinical and haematological parameters. (10901597)
2000
36
Acute cauda equina syndrome caused by a gas-containing prolapsed intervertebral disk. (11132986)
2000
37
Cauda equina syndrome as the isolated presentation of sarcoidosis. (10993507)
2000
38
Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997. (10225068)
1999
39
A review of imaging techniques for canine cauda equina syndrome. (9710129)
1998
40
Cauda equina syndrome with elevated adenosine deaminase in a patient with HIV infection]. (8519829)
1995
41
An unusual complication of ureteroscopy with general anaesthesia: cauda equina syndrome. (7551898)
1995
42
Magnetic resonance imaging of cauda equina syndrome in ankylosing spondylitis: a case report. (7849372)
1995
43
Subarachnoid catheters and the cauda equina syndrome: hypotheses in need of trial. (8141477)
1994
44
Acute cauda equina syndrome. Diagnostic advantage of MRI. (8178242)
1994
45
Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome. (1335859)
1992
46
Long term follow up of patients with cauda equina syndrome due to intraspinal lipoma. (1598179)
1992
47
Laminectomy for treatment of cauda equina syndrome in a cat. (3972714)
1985
48
A urodynamic study of cauda equina syndrome due to lumbar disc herniation. (7385464)
1980
49
Cauda equina syndrome--a clinical study. (4712578)
1973
50
Disk rupture with cauda equina syndrome after chiropractic adjustment. (5235409)
1967

Variations for Cauda Equina Syndrome

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Expression for genes affiliated with Cauda Equina Syndrome

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Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for genes affiliated with Cauda Equina Syndrome

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Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BMP2, EGR2
2
Show member pathways
9.2EGR2, FOS
39.2BMP2, FOS
48.8BMP2, EGR2, FOS

GO Terms for genes affiliated with Cauda Equina Syndrome

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Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system developmentGO:000742210.0EGR2, PMP22
2skeletal muscle cell differentiationGO:00359149.6EGR2, FOS
3SMAD protein signal transductionGO:00603959.4BMP2, FOS
4odontogenesis of dentin-containing toothGO:00424759.2ANKRD11, BMP2
5positive regulation of transcription, DNA-templatedGO:00458938.8BMP2, EGR2, FOS

Sources for Cauda Equina Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet