MCID: CDQ001
MIFTS: 38

Cauda Equina Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

MalaCards integrated aliases for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 50 14 69
Polyradiculopathy 42 69
Cauda Equina 52

Classifications:



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Disease Ontology 12 DOID:11577
ICD10 33 G83.4
ICD9CM 35 344.6
MeSH 42 D011128
NCIt 47 C35436
UMLS 69 C0392548

Summaries for Cauda Equina Syndrome

NIH Rare Diseases : 50 cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; "foot drop"; problems with bowel and/or bladder control; and sexual dysfunction. cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. last updated: 5/17/2015

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma. An important gene associated with Cauda Equina Syndrome is NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1), and among its related pathways/superpathways are Brain-Derived Neurotrophic Factor (BDNF) signaling pathway and Adipogenesis. The drugs Procaine and Chloroprocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and b cells, and related phenotype is limbs/digits/tail.

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 72 Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes... more...

Related Diseases for Cauda Equina Syndrome

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

MGI Mouse Phenotypes related to Cauda Equina Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 BMP2 EGR2 NR1D1 PMP22

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
2
Chloroprocaine Approved 133-16-4 8612
3 Central Nervous System Depressants
4 Anesthetics
5 Anesthetics, Local
6 Peripheral Nervous System Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
2 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056
3 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
4 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
5 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Not yet recruiting NCT02806167

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

39
Spinal Cord, Bone, B Cells, Lung, Breast, T Cells, Myeloid

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 540)
id Title Authors Year
1
Incomplete cauda equina syndrome secondary to haemorrhage within a Tarlov cyst. ( 28784878 )
2017
2
Leptomeningeal Carcinomatosis Presenting as Cauda Equina Syndrome. ( 28904471 )
2017
3
Cauda Equina Syndrome Due to Vigorous Back Massage With Spinal Manipulation in a Patient With Pre-Existing Lumbar Disc Herniation: A Case Report and Literature Review. ( 28796647 )
2017
4
Contained ruptured abdominal aortic aneurysm presenting as cauda equina syndrome. ( 28062419 )
2017
5
Neisseria meningitidis subdural empyema causing acute cauda equina syndrome. ( 28653638 )
2017
6
Dengue fever presenting as cauda equina syndrome. ( 28739570 )
2017
7
Definitions of traumatic conus medullaris and cauda equina syndrome: a systematic literature review. ( 28534496 )
2017
8
Guidelines for cauda equina syndrome. Red flags and white flags. Systematic review and implications for triage. ( 28637110 )
2017
9
Elsberg syndrome: A rarely recognized cause of cauda equina syndrome and lower thoracic myelitis. ( 28534040 )
2017
10
The lived experience of Cauda Equina Syndrome: a qualitative analysis. ( 28786413 )
2017
11
Prediction of the outcome of bladder dysfunction based on electrically induced reflex findings in patients with cauda equina syndrome: A retrospective study. ( 28538420 )
2017
12
Cauda equina syndrome caused by filum terminale lipoma: magnetic resonance imaging features and surgical treatment. ( 28444101 )
2017
13
Erratum: Against the odds: extraordinary recovery from complete cauda equina syndrome following L3 fracture. Time still matters. ( 28503318 )
2017
14
Anterior lumbar discectomy and fusion for acute cauda equina syndrome caused by recurrent disc prolapse: report of 3 cases. ( 28708040 )
2017
15
Obesity and spinal epidural lipomatosis in cauda equina syndrome. ( 28756300 )
2017
16
Acute flaccid paraparesis (cauda equina syndrome) in a patient with Bardet-Biedl syndrome. ( 28566787 )
2017
17
Persistent cauda equina syndrome after caudal epidural injection under severe spinal stenosis: a case report. ( 28652808 )
2017
18
Editorial. Use of anterior lumbar discectomy and interbody fusion in the management of recurrent lumbar disc herniation and cauda equina syndrome. ( 28708042 )
2017
19
Cauda Equina Syndrome Due To Dural Sac Shift with Engorgement of the Epidural Venous Plexus: Rare Complication After Lumbar Microdiscectomy. ( 28546122 )
2017
20
Early cauda equina syndrome (CESE). ( 28478686 )
2017
21
Neurosurgeon or spinal surgeon - who should treat cauda equina syndrome? ( 28637116 )
2017
22
A rare case of multiple spinal epidural abscesses and cauda equina syndrome presenting to the emergency department following acupuncture. ( 27456667 )
2016
23
Spinal myxopapillary ependymoma with interval drop metastasis presenting as cauda equina syndrome: case report and review of literature. ( 27757435 )
2016
24
Prevalence of thoracic spine lesions masquerading as cauda equina syndrome: yield of a novel magnetic resonance imaging protocol. ( 27815809 )
2016
25
Differential diagnosis and treatment of acute cauda equina syndrome in the human immunodeficiency virus positive patient: a case report and review of the literature. ( 27268102 )
2016
26
Cauda equina syndrome. An emergency, some unexpected severe symptoms and conservative treatment. ( 27999827 )
2016
27
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. ( 26882861 )
2016
28
A Letter to the Editor regarding, "Time to Surgery and Outcomes in Cauda Equina Syndrome: An Analysis of 45 Cases." Critique of Bydon et al. ( 27637700 )
2016
29
Lumbar subdural cerebrospinal fluid collection with acute cauda equina syndrome after posterior fossa decompression for Chiari malformation Type I: case report. ( 27081710 )
2016
30
Cauda Equina Syndrome Secondary to Leptomeningeal Carcinomatosis of Gastroesophageal Junction Cancer. ( 27239185 )
2016
31
Percutaneous Endoscopic Lumbar Discectomy for Cauda Equina Syndrome. ( 27504566 )
2016
32
Impact of MR Neurography in Patients with Chronic Cauda Equina Syndrome Presenting as Chronic Pelvic Pain and Dysfunction. ( 28059708 )
2016
33
Against the odds: extraordinary recovery from complete cauda equina syndrome following L3 fracture. Time still matters. ( 28053769 )
2016
34
Impact of timing on surgical outcome in patients with cauda equina syndrome caused by lumbar disc herniation. ( 27452326 )
2016
35
18F-FDG PET/CT Imaging of Cauda Equina Syndrome Secondary to Leptomeningeal Metastatic Breast Cancer. ( 27607169 )
2016
36
Endoscope-assisted oblique lumbar interbody fusion for the treatment of cauda equina syndrome: a technical note. ( 27924416 )
2016
37
Cauda equina syndrome secondary to lumbar disc herniation: Surgical delay and its relationship with prognosis. ( 26948511 )
2016
38
Time to Surgery and Outcomes in Cauda Equina Syndrome: An Analysis of 45 Cases. ( 26724637 )
2016
39
Neurological Recovery in Two Patients with Cauda Equina Syndrome Secondary to L5 Lumbar Spine Giant Cell Tumour after Treatment with Denosumab without Surgery. ( 27790326 )
2016
40
Comment on "Cauda equina syndrome: an uncommon cause of urinary retention in a young woman". ( 27525689 )
2016
41
Development of a toolkit for early identification of cauda equina syndrome. ( 27098202 )
2016
42
Interest of isokinetic in the cauda equina syndrome. ( 27676769 )
2016
43
Cauda equina syndrome: an uncommon cause of urinary retention in a young woman. ( 26872649 )
2016
44
Erratum: Management of neglected sacral fracture with cauda equina syndrome: report of two cases with review of literature. ( 28067337 )
2016
45
Unique Presentation of Hematometrocolpos Mimicking Cauda Equina Syndrome: Severe Back Pain and Urinary Incontinence in an Adolescent Girl. ( 26924512 )
2016
46
Posterior Epidural Migration of a Sequestrated Lumbar Disk Fragment Causing Cauda Equina Syndrome in an Old Patient: A Case Report. ( 27257401 )
2016
47
Poster 227 Cauda Equina Syndrome after Lumbar Disk Herniation: A Case Report. ( 27672986 )
2016
48
Primary Ewing sarcoma of the lumbar spine presenting as cauda equina syndrome in a pediatric patient. ( 26882852 )
2016
49
Does Early Surgical Decompression in Cauda Equina Syndrome Improve Bladder Outcome?: Comments on a Recent Study by Srikandarajah et al. ( 27831995 )
2016
50
Standards of care in cauda equina syndrome. ( 27240099 )
2016

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.11 BMP2 EGR2
2 10.74 BMP2 EGR2

GO Terms for Cauda Equina Syndrome

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.33 BMP2 EGR2 NR1D1
2 myelination GO:0042552 8.96 EGR2 PMP22
3 peripheral nervous system development GO:0007422 8.62 EGR2 PMP22

Sources for Cauda Equina Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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