MCID: CDQ001
MIFTS: 42

Cauda Equina Syndrome malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

About this section

Aliases & Descriptions for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 11 48 13 68
Polyradiculopathy 39 68
 
Cauda Equina 50

Classifications:



External Ids:

Disease Ontology11 DOID:11577
ICD1030 G83.4
ICD9CM32 344.6
MeSH39 D011128
NCIt45 C35436

Summaries for Cauda Equina Syndrome

About this section
NIH Rare Diseases:48 Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. Signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; foot drop; problems with bowel and/or bladder control; and sexual dysfunction. Cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. Treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. Physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. Last updated: 5/17/2015

MalaCards based summary: Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma, and has symptoms including edema of spinal cord, radicular pain and pain in spine. An important gene associated with Cauda Equina Syndrome is DPYSL3 (Dihydropyrimidinase Like 3), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and BDNF signaling pathway. Affiliated tissues include spinal cord, b cells and bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Disease Ontology:11 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia:71 Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes... more...

Related Diseases for Cauda Equina Syndrome

About this section

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to cauda equina syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

About this section

UMLS symptoms related to Cauda Equina Syndrome:


edema of spinal cord, radicular pain, pain in spine

MGI Mouse Phenotypes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.3BMP2, EGR2, FOS, PMP22
2MP:00053718.6BMP2, EGR2, FOS, PMP22

Drugs & Therapeutics for Cauda Equina Syndrome

About this section

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Chloroprocaineapproved18133-16-48612
Synonyms:
133-16-4
2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate
2-(Diethylaminoethyl)-4-amino-2-chlorobenzoate
2-Chloroprocaine
2-diethylaminoethyl 4-amino-2-chlorobenzoate
3858-89-7 (hydrochloride)
4-14-00-01273 (Beilstein Handbook Reference)
4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester
4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
AC1L1RCM
BRN 2808071
Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester
C07877
C13H19ClN2O2
CHEBI:3636
CHLOROPROCAINE
CID8612
Chlor-procaine
Chloroprocain
 
Chloroprocaine
Chloroprocaine (INN)
Chloroprocaine [INN]
Chloroprocaine hydrochloride
Chloroprocainum
Chloroprocainum [INN-Latin]
Chlorprocaine
Chlorprocainum
Cloroprocaina
Cloroprocaina [INN-Spanish]
D07678
DB01161
HSDB 3301
Halestyn
LS-35706
Nesacaine
Nesacaine MPF
Nesacaine-Ce
Piocaine
UNII-5YVB0POT2H
2
Procaineapproved, investigational, vet_approved4859-46-14914
Synonyms:
.beta.-(Diethylamino)ethyl p-aminobenzoate
.beta.-Diethylaminoethyl 4-aminobenzoate
2-(Diethylamino)ethyl 4-aminobenzoate
2-(Diethylamino)ethyl p-aminobenzoate
2-(Diethylamino)ethyl-4-aminobenzoate
2-Diethylaminoethyl 4-aminobenzoate
2-Diethylaminoethyl p-aminobenzoate
2-Diethylaminoethylester kyseliny p-aminobenzoove
2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]
4-14-00-01138 (Beilstein Handbook Reference)
4-Aminobenzoesaeure-beta-diethylaminoethylester
4-Aminobenzoic acid 2-(diethylamino) ethyl ester
4-Aminobenzoic acid diethylaminoethyl ester
4-aminobenzoic acid 2-diethylaminoethyl ester
59-46-1
91484-72-9
AB00053531
AC1L1J8C
AC1Q2ZE2
AKOS000115407
Allocaine
Anticort
Anticort (TM)
Anuject
BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE
BPBio1_000179
BRD-K24616672-003-05-2
BRN 0913480
BSPBio_000161
BSPBio_002231
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester
Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
C07375
CAS-51-05-8
CHEBI:8430
CHEMBL569
CID4914
D08422
DB00721
Diethylaminoethyl p-aminobenzoate
DivK1c_000120
Duracaine
EINECS 200-426-9
Factor H3
Gerokit
Gerovital
Gerovital H-3
HSDB 3388
I06-1439
IDI1_000120
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
Jenacain
Jenacaine
KBio1_000120
KBio2_001318
KBio2_003886
KBio2_006454
KBio3_001731
 
KBioGR_000975
KBioSS_001318
LS-35778
Lopac-P-9879
Lopac0_000966
MolPort-000-889-177
NCGC00015864-01
NCGC00015864-02
NCGC00015864-04
NCGC00162298-01
NINDS_000120
NSC 169497
NSC169497
Nissocaine
Norocaine
Novocain
Novocaine
Prestwick0_000041
Prestwick1_000041
Prestwick2_000041
Prestwick3_000041
Procain
Procaina
Procaina [INN-Spanish]
Procaine (INN)
Procaine HCl
Procaine [INN:BAN]
Procaine, base
Procainum
Procainum [INN-Latin]
SP-01A
SP01
SP01A
SPBio_001331
SPBio_002082
STK177303
STOCK2S-12721
Scurocaine
Solution of novocain
Solution of novocain (TN)
Spectrum2_001296
Spectrum3_000556
Spectrum4_000488
Spectrum5_001186
Spectrum_000838
Spinocaine
Stoff H3
UNII-4Z8Y51M438
Vitamin H3
WLN: ZR DVO2N2&2
beta-(Diethylamino)ethyl 4-aminobenzoate
beta-(Diethylamino)ethyl p-aminobenzoate
beta-Diethylaminoethyl 4-aminobenzoate
p-Aminobenzoic acid 2-diethylaminoethyl ester
p-Aminobenzoyldiethylaminoethanol
p-Aminobenzyoyldiethylaminoethanol
procaine
╬▓-(diethylamino)ethyl 4-aminobenzoate
╬▓-(diethylamino)ethyl p-aminobenzoate
3Peripheral Nervous System Agents22776
4Central Nervous System Depressants12806
5Anesthetics, Local3272
6Anesthetics9001

Interventional clinical trials:

idNameStatusNCT IDPhase
1Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)Not yet recruitingNCT02591901Phase 2
2Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated DiscUnknown statusNCT00927056
3Peristeen Bowel Irrigation System in Cauda EquinaCompletedNCT01784328
4Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal AnaesthesiaCompletedNCT02067806
5Post-void Bladder Scanning in Acute Cauda Equina SyndromeNot yet recruitingNCT02806167

Search NIH Clinical Center for Cauda Equina Syndrome


Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

About this section

Anatomical Context for Cauda Equina Syndrome

About this section

MalaCards organs/tissues related to Cauda Equina Syndrome:

36
Spinal cord, B cells, Bone, Breast, Lung, T cells, Myeloid

Publications for Cauda Equina Syndrome

About this section

Articles related to Cauda Equina Syndrome:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Contained ruptured abdominal aortic aneurysm presenting as cauda equina syndrome. (28062419)
2017
2
Against the odds: extraordinary recovery from complete cauda equina syndrome following L3 fracture. Time still matters. (28053769)
2016
3
Lumbar subdural cerebrospinal fluid collection with acute cauda equina syndrome after posterior fossa decompression for Chiari malformation Type I: case report. (27081710)
2016
4
Cauda Equina Syndrome Secondary to Leptomeningeal Carcinomatosis of Gastroesophageal Junction Cancer. (27239185)
2016
5
Cauda equina syndrome due to large B-cell lymphoma: a case report. (26753799)
2016
6
Intramedullary Abscess by Staphylococcus aureus Presenting as Cauda Equina Syndrome to the Emergency Department. (27293918)
2016
7
Interest of isokinetic in the cauda equina syndrome. (27676769)
2016
8
Indeterminate cauda equina syndrome: A case report. (26908977)
2016
9
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. (26882861)
2016
10
Prevalence of thoracic spine lesions masquerading as cauda equina syndrome: yield of a novel magnetic resonance imaging protocol. (27815809)
2016
11
Unique Presentation of Hematometrocolpos Mimicking Cauda Equina Syndrome: Severe Back Pain and Urinary Incontinence in an Adolescent Girl. (26924512)
2016
12
Migratory low velocity intradural lumbosacral spinal bullet causing cauda equina syndrome: report of a case and review of literature. (27942941)
2016
13
Comment on "Cauda equina syndrome: an uncommon cause of urinary retention in a young woman". (27525689)
2016
14
Poster 227 Cauda Equina Syndrome after Lumbar Disk Herniation: A Case Report. (27672986)
2016
15
Erratum: Management of neglected sacral fracture with cauda equina syndrome: report of two cases with review of literature. (28067337)
2016
16
Does Early Surgical Decompression in Cauda Equina Syndrome Improve Bladder Outcome?: Comments on a Recent Study by Srikandarajah et al. (27831995)
2016
17
Standards of care in cauda equina syndrome. (27240099)
2016
18
Cauda equina syndrome secondary to lumbar disc herniation: Surgical delay and its relationship with prognosis. (26948511)
2016
19
Examination of The Predictive Power of Electromyography and Urodynamic Study in Patients with Cauda Equina Syndrome (Horse Tail Syndrome). (28077887)
2016
20
Posterior Epidural Migration of a Sequestrated Lumbar Disk Fragment Causing Cauda Equina Syndrome in an Old Patient: A Case Report. (27257401)
2016
21
Brucellar spondylodiscitis with rapidly progressive spinal epidural abscess showing cauda equina syndrome. (28053732)
2016
22
Neurological Recovery in Two Patients with Cauda Equina Syndrome Secondary to L5 Lumbar Spine Giant Cell Tumour after Treatment with Denosumab without Surgery. (27790326)
2016
23
Primary Ewing sarcoma of the lumbar spine presenting as cauda equina syndrome in a pediatric patient. (26882852)
2016
24
Development of a toolkit for early identification of cauda equina syndrome. (27098202)
2016
25
Spinal myxopapillary ependymoma with interval drop metastasis presenting as cauda equina syndrome: case report and review of literature. (27757435)
2016
26
Cauda equina syndrome. An emergency, some unexpected severe symptoms and conservative treatment. (27999827)
2016
27
Endoscope-assisted oblique lumbar interbody fusion for the treatment of cauda equina syndrome: a technical note. (27924416)
2016
28
Time to Surgery and Outcomes in Cauda Equina Syndrome: An Analysis of 45 Cases. (26724637)
2016
29
A rare case of multiple spinal epidural abscesses and cauda equina syndrome presenting to the emergency department following acupuncture. (27456667)
2016
30
A Letter to the Editor regarding, "Time to Surgery and Outcomes in Cauda Equina Syndrome: An Analysis of 45 Cases." Critique of Bydon et al. (27637700)
2016
31
Cauda equina syndrome: an uncommon cause of urinary retention in a young woman. (26872649)
2016
32
18F-FDG PET/CT Imaging of Cauda Equina Syndrome Secondary to Leptomeningeal Metastatic Breast Cancer. (27607169)
2016
33
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. (27891041)
2016
34
Impact of MR Neurography in Patients with Chronic Cauda Equina Syndrome Presenting as Chronic Pelvic Pain and Dysfunction. (28059708)
2016
35
A case report of extramedullary haematopoeisis in lumbosacral region presenting as cauda equina syndrome. (27652196)
2016
36
Differential diagnosis and treatment of acute cauda equina syndrome in the human immunodeficiency virus positive patient: a case report and review of the literature. (27268102)
2016
37
Impact of timing on surgical outcome in patients with cauda equina syndrome caused by lumbar disc herniation. (27452326)
2016
38
Doing More with Less: Diagnostic Accuracy of CT in Suspected Cauda Equina Syndrome. (27789449)
2016
39
Percutaneous Endoscopic Lumbar Discectomy for Cauda Equina Syndrome. (27504566)
2016
40
Post-hemorrhagic hydrocephalus presenting as cauda equina syndrome in a patient with spinal dysraphism. (26675625)
2016
41
Cauda equina syndrome: is the current management of patients presenting to district general hospitals fit for purpose? A personal view based on a review of the literature and a medicolegal experience. (26430015)
2015
42
Giant malignant peripheral nerve sheath tumor with cauda equina syndrome and subarachnoid hemorrhage: Complications in a case of type 1 neurofibromatosis. (26283846)
2015
43
Cauda equina syndrome due to intravascular lymphoma: diagnosis by nasal biopsy. (25717092)
2015
44
Cauda Equina Syndrome in a 36 Week Gravida Patient. (26394499)
2015
45
The accuracy of clinical symptoms in detecting cauda equina syndrome in patients undergoing acute MRI of the spine. (26306934)
2015
46
Neoplastic cauda equina syndrome: a neuroimaging-based review. (26442520)
2015
47
Thoracic spinal cord compression masquerading as cauda equina syndrome: a case report. (26346050)
2015
48
Cauda equina syndrome after repeated spinal attempts: A case report and review of the literature. (25829916)
2015
49
Unusual delayed presentation of cauda equina syndrome after failed spinal anesthesia. (26240562)
2015
50
Hemorrhagic schwannoma presenting with subarachnoid hemorrhage and resulting cauda equina syndrome. (26193683)
2015

Variations for Cauda Equina Syndrome

About this section

Expression for genes affiliated with Cauda Equina Syndrome

About this section
Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for genes affiliated with Cauda Equina Syndrome

About this section

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4EGR2, FOS
29.0BMP2, EGR2, FOS

GO Terms for genes affiliated with Cauda Equina Syndrome

About this section

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron projection developmentGO:001097710.4DPYSL3, PMP22
2positive regulation of pri-miRNA transcription from RNA polymerase II promoterGO:190289510.3BMP2, FOS
3myelinationGO:004255210.2EGR2, PMP22
4peripheral nervous system developmentGO:000742210.2EGR2, PMP22
5skeletal muscle cell differentiationGO:00359149.9EGR2, FOS
6positive regulation of transcription, DNA-templatedGO:00458939.6BMP2, EGR2, FOS
7SMAD protein signal transductionGO:00603959.5BMP2, FOS
8positive regulation of transcription from RNA polymerase II promoterGO:00459448.9BMP2, BRD4, EGR2, FOS

Molecular functions related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:00036828.6BRD4, EGR2, FOS

Sources for Cauda Equina Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet