MCID: CDQ001
MIFTS: 48

Cauda Equina Syndrome malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

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Aliases & Descriptions for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 10 45 12 65
Polyradiculopathy 36 65
 
Cauda Equina 47

Classifications:



External Ids:

Disease Ontology10 DOID:11577
ICD1027 G83.4
ICD9CM29 344.6
MeSH36 D011128
NCIt42 C35436
UMLS65 C0392548

Summaries for Cauda Equina Syndrome

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NIH Rare Diseases:45 Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; "foot drop"; problems with bowel and/or bladder control; and sexual dysfunction. cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. last updated: 5/17/2015

MalaCards based summary: Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma, and has symptoms including pain in spine, radicular pain and edema of spinal cord. An important gene associated with Cauda Equina Syndrome is CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6), and among its related pathways are Arachidonate Epoxygenase / Epoxide Hydrolase and Losartan Pathway, Pharmacokinetics. Affiliated tissues include spinal cord, t cells and breast.

Disease Ontology:10 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia:68 Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes... more...

Related Diseases for Cauda Equina Syndrome

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Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to cauda equina syndrome

Symptoms for Cauda Equina Syndrome

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UMLS symptoms related to Cauda Equina Syndrome:


pain in spine, radicular pain, edema of spinal cord

Drugs & Therapeutics for Cauda Equina Syndrome

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Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Chloroprocaineapproved15133-16-48612
Synonyms:
133-16-4
2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate
2-(Diethylaminoethyl)-4-amino-2-chlorobenzoate
2-Chloroprocaine
2-diethylaminoethyl 4-amino-2-chlorobenzoate
3858-89-7 (hydrochloride)
4-14-00-01273 (Beilstein Handbook Reference)
4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester
4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
AC1L1RCM
BRN 2808071
Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester
C07877
C13H19ClN2O2
CHEBI:3636
CHLOROPROCAINE
CID8612
Chlor-procaine
Chloroprocain
 
Chloroprocaine
Chloroprocaine (INN)
Chloroprocaine Hydrochloride
Chloroprocaine [INN]
Chloroprocaine hydrochloride
Chloroprocainum
Chloroprocainum [INN-Latin]
Chlorprocaine
Chlorprocainum
Cloroprocaina
Cloroprocaina [INN-Spanish]
D07678
DB01161
HSDB 3301
Halestyn
LS-35706
Nesacaine
Nesacaine MPF
Nesacaine-Ce
Piocaine
UNII-5YVB0POT2H
2
Procaineapproved, investigational3559-46-14914
Synonyms:
.beta.-(Diethylamino)ethyl p-aminobenzoate
.beta.-Diethylaminoethyl 4-aminobenzoate
2-(Diethylamino)ethyl 4-aminobenzoate
2-(Diethylamino)ethyl p-aminobenzoate
2-(Diethylamino)ethyl-4-aminobenzoate
2-Diethylaminoethyl 4-aminobenzoate
2-Diethylaminoethyl p-aminobenzoate
2-Diethylaminoethylester kyseliny p-aminobenzoove
2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]
4-14-00-01138 (Beilstein Handbook Reference)
4-Aminobenzoesaeure-beta-diethylaminoethylester
4-Aminobenzoic acid 2-(diethylamino) ethyl ester
4-Aminobenzoic acid 2-diethylaminoethyl ester
4-Aminobenzoic acid diethylaminoethyl ester
59-46-1
91484-72-9
AB00053531
AC1L1J8C
AC1Q2ZE2
AKOS000115407
Allocaine
Anticort
Anticort (TM)
Anuject
BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE
BPBio1_000179
BRD-K24616672-003-05-2
BRN 0913480
BSPBio_000161
BSPBio_002231
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester
Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
C07375
CAS-51-05-8
CHEBI:8430
CHEMBL569
CID4914
D08422
DB00721
Diethylaminoethyl p-aminobenzoate
DivK1c_000120
Duracaine
EINECS 200-426-9
Factor H3
Gerokit
Gerovital
Gerovital H-3
HSDB 3388
I06-1439
IDI1_000120
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
Jenacain
Jenacaine
KBio1_000120
KBio2_001318
KBio2_003886
KBio2_006454
KBio3_001731
KBioGR_000975
 
KBioSS_001318
LS-35778
Lopac-P-9879
Lopac0_000966
MolPort-000-889-177
NCGC00015864-01
NCGC00015864-02
NCGC00015864-04
NCGC00162298-01
NINDS_000120
NSC 169497
NSC169497
Nissocaine
Norocaine
Novocain
Novocaine
Prestwick0_000041
Prestwick1_000041
Prestwick2_000041
Prestwick3_000041
Procain
Procaina
Procaina [INN-Spanish]
Procaine
Procaine (INN)
Procaine HCl
Procaine Hydrochloride
Procaine [INN:BAN]
Procaine, base
Procainum
Procainum [INN-Latin]
SP-01A
SP01
SP01A
SPBio_001331
SPBio_002082
STK177303
STOCK2S-12721
Scurocaine
Solution of novocain
Solution of novocain (TN)
Spectrum2_001296
Spectrum3_000556
Spectrum4_000488
Spectrum5_001186
Spectrum_000838
Spinocaine
Stoff H3
UNII-4Z8Y51M438
Vitamin H3
WLN: ZR DVO2N2&2
beta-(Diethylamino)ethyl 4-aminobenzoate
beta-(Diethylamino)ethyl P-aminobenzoate
beta-(Diethylamino)ethyl p-aminobenzoate
beta-Diethylaminoethyl 4-aminobenzoate
p-Aminobenzoic acid 2-diethylaminoethyl ester
p-Aminobenzoyldiethylaminoethanol
p-Aminobenzyoyldiethylaminoethanol
procaine
╬▓-(diethylamino)ethyl 4-aminobenzoate
╬▓-(diethylamino)ethyl p-aminobenzoate
3Peripheral Nervous System Agents18510
4Central Nervous System Depressants10016
5Anesthetics, Local2347
6Anesthetics7385

Interventional clinical trials:

idNameStatusNCT IDPhase
1Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)Not yet recruitingNCT02591901Phase 2
2Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal AnaesthesiaRecruitingNCT02067806
3Peristeen Bowel Irrigation System in Cauda EquinaActive, not recruitingNCT01784328
4Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated DiscEnrolling by invitationNCT00927056

Search NIH Clinical Center for Cauda Equina Syndrome


Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

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Anatomical Context for Cauda Equina Syndrome

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MalaCards organs/tissues related to Cauda Equina Syndrome:

33
Spinal cord, T cells, Breast, Prostate, Bone, Lung, Thyroid

Animal Models for Cauda Equina Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Cauda Equina Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Cauda Equina Syndrome

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Articles related to Cauda Equina Syndrome:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Cauda equina syndrome secondary to lumbar disc herniation: Surgical delay and its relationship with prognosis. (26948511)
2016
2
Cauda equina syndrome: is the current management of patients presenting to district general hospitals fit for purpose? A personal view based on a review of the literature and a medicolegal experience. (26430015)
2015
3
An acute bleeding metastatic spinal tumor from HCC causes an acute onset of cauda equina syndrome. (26298047)
2015
4
Giant malignant peripheral nerve sheath tumor with cauda equina syndrome and subarachnoid hemorrhage: Complications in a case of type 1 neurofibromatosis. (26283846)
2015
5
Neurological deterioration in cauda equina syndrome is probably progressive and continuous. Implications for clinical management. (26401618)
2015
6
Cauda equina syndrome caused by a spontaneous spinal haematoma. (26123457)
2015
7
ACUTE CAUDA EQUINA SYNDROME CAUSED BY A DISK LESION: IS EMERGENT SURGERY THE CORRECT OPTION? (25608248)
2015
8
Cauda equina syndrome due to intravascular lymphoma: diagnosis by nasal biopsy. (25717092)
2015
9
Cauda Equina Syndrome in a 36 Week Gravida Patient. (26394499)
2015
10
The accuracy of clinical symptoms in detecting cauda equina syndrome in patients undergoing acute MRI of the spine. (26306934)
2015
11
Neoplastic cauda equina syndrome: a neuroimaging-based review. (26442520)
2015
12
Cauda equina syndrome: evaluation of the clinical outcome. (24763893)
2014
13
Cauda equina syndrome: implications for primary care. (24567588)
2014
14
Why not decompress early? The cauda equina syndrome. (24631648)
2014
15
Foix-alajouanine syndrome presenting as acute cauda equina syndrome: a case report. (25396108)
2014
16
A case of cauda equina syndrome in early-onset chronic inflammatory demyelinating polyneuropathy clinically similar to charcot-marie-tooth disease type 1. (25237436)
2014
17
Cauda equina syndrome secondary to intradural renal cell carcinoma metastasis haemorrhage. (22985045)
2013
18
Cauda equina syndrome after a TLIF resulting from postoperative expansion of a hydrogel dural sealant. (21952743)
2012
19
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. (23084725)
2012
20
Cauda equina syndrome after spinal anaesthesia in a patient with asymptomatic tubercular arachnoiditis. (22013254)
2011
21
Is cauda equina syndrome being treated within the recommended time frame? (21311382)
2011
22
Pellegrini-stieda disease in a patient with cauda equina syndrome. (20134309)
2011
23
Lumboperitoneal shunting of cerebrospinal fluid versus anti-tumor necrosis factor treatment of cauda equina syndrome in ankylosing spondylitis: comment on the article by Cornec et al. (20178129)
2010
24
Cauda Equina Syndrome. (19711885)
2009
25
Cauda equina syndrome caused by a complete traumatic lumbar disc complex extrusion without alterations of facet joints. (19910776)
2009
26
Cauda equina syndrome: A rare complication in intensive care. (19838356)
2009
27
Cauda equina syndrome presentation of sacral insufficiency fractures. (17177021)
2007
28
Cauda equina syndrome as a rare manifestation of leukemia relapse during postallograft period. (16749661)
2006
29
Postoperative cauda equina syndrome in patients undergoing single-level lumbar microdiscectomy. Report of two cases. (16122210)
2005
30
Posterior epidural migration of sequestered lumbar disc fragment causing cauda equina syndrome. (16482671)
2005
31
Cauda equina syndrome as a postoperative complication of lumbar spine surgery. (15202877)
2004
32
The irreplaceable image: Leptomeningeal leukemia masquerading as cauda equina syndrome: appraisal by magnetic resonance imaging. (11602427)
2001
33
Cauda equina syndrome. (11311464)
2001
34
Cauda equina syndrome as a postoperative complication in five patients operated for lumbar disc herniation. (11224866)
2001
35
Lumbar pannus presenting as cauda equina syndrome in a patient with longstanding rheumatoid arthritis. (11296971)
2001
36
Cauda equina syndrome secondary to idiopathic spinal epidural lipomatosis. (11224868)
2001
37
Hydroxyurea therapy in paraparesis and cauda equina syndrome due to extramedullary haematopoiesis in thalassaemia: improvement of clinical and haematological parameters. (10901597)
2000
38
Acute cauda equina syndrome caused by a gas-containing prolapsed intervertebral disk. (11132986)
2000
39
Cauda equina syndrome as the isolated presentation of sarcoidosis. (10993507)
2000
40
Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997. (10225068)
1999
41
Cauda equina syndrome with elevated adenosine deaminase in a patient with HIV infection]. (8519829)
1995
42
An unusual complication of ureteroscopy with general anaesthesia: cauda equina syndrome. (7551898)
1995
43
Magnetic resonance imaging of cauda equina syndrome in ankylosing spondylitis: a case report. (7849372)
1995
44
Subarachnoid catheters and the cauda equina syndrome: hypotheses in need of trial. (8141477)
1994
45
Acute cauda equina syndrome. Diagnostic advantage of MRI. (8178242)
1994
46
Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome. (1335859)
1992
47
Long term follow up of patients with cauda equina syndrome due to intraspinal lipoma. (1598179)
1992
48
A urodynamic study of cauda equina syndrome due to lumbar disc herniation. (7385464)
1980
49
Cauda equina syndrome--a clinical study. (4712578)
1973
50
Disk rupture with cauda equina syndrome after chiropractic adjustment. (5235409)
1967

Variations for Cauda Equina Syndrome

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Expression for genes affiliated with Cauda Equina Syndrome

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Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for genes affiliated with Cauda Equina Syndrome

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Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.5CYP2C8, CYP2C9
29.5CYP2C9, CYP3A4
39.5CYP2C9, CYP3A4
4
Show member pathways
9.4CYP2C8, CYP3A4
59.4CYP2B6, CYP2C9
69.1AR, CYP3A4
7
Show member pathways
9.0CYP2C8, CYP2C9, CYP3A4
89.0CYP2C8, CYP2C9, CYP3A4
9
Show member pathways
9.0CYP2C8, CYP2C9, CYP3A4
10
Show member pathways
8.9CYP2B6, CYP2D6, CYP3A4
11
Show member pathways
8.9CYP2B6, CYP2D6, CYP3A4
128.9CYP2B6, CYP2C9, CYP3A4
138.9CYP2B6, CYP2C9, CYP3A4
14
Show member pathways
8.6CYP2C8, CYP2C9, CYP2D6, CYP3A4
15
Show member pathways
8.5CYP2B6, CYP2C9, CYP2D6, CYP3A4
16
Show member pathways
8.5CYP2B6, CYP2C9, CYP2D6, CYP3A4
17
Show member pathways
8.4CYP2B6, CYP2C8, CYP2C9, CYP3A4
18
Show member pathways
7.9CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP3A4
19
Show member pathways
7.9CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP3A4
20
Show member pathways
7.9CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP3A4
21
Show member pathways
7.9CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP3A4
22
Show member pathways
7.9CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP3A4

GO Terms for genes affiliated with Cauda Equina Syndrome

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Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1arachidonic acid metabolic processGO:00193699.7CYP2C9, CYP2D6
2heterocycle metabolic processGO:00464839.4CYP2D6, CYP3A4
3exogenous drug catabolic processGO:00427389.1CYP2B6, CYP2C9
4monoterpenoid metabolic processGO:00160989.1CYP2C9, CYP2D6, CYP3A4
5epoxygenase P450 pathwayGO:00193738.9CYP2B6, CYP2C8, CYP2C9
6xenobiotic metabolic processGO:00068058.0CYP2B6, CYP2C8, CYP2C9, CYP2D6, CYP3A4

Molecular functions related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:00044979.4CYP2C8, CYP3A4
2caffeine oxidase activityGO:00348759.3CYP2C8, CYP2C9, CYP3A4
3arachidonic acid epoxygenase activityGO:00083928.6CYP2B6, CYP2C8, CYP2C9

Sources for Cauda Equina Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet