MCID: CDQ001
MIFTS: 40

Cauda Equina Syndrome malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

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Aliases & Descriptions for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 11 46 13 66
Polyradiculopathy 37
 
Cauda Equina 48

Classifications:



External Ids:

Disease Ontology11 DOID:11577
ICD1028 G83.4
ICD9CM30 344.6
MeSH37 D011128
NCIt43 C35436

Summaries for Cauda Equina Syndrome

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NIH Rare Diseases:46 Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; "foot drop"; problems with bowel and/or bladder control; and sexual dysfunction. cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. last updated: 5/17/2015

MalaCards based summary: Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma, and has symptoms including edema of spinal cord, radicular pain and pain in spine. An important gene associated with Cauda Equina Syndrome is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways are Adipogenesis and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include spinal cord, b cells and bone, and related mouse phenotype hearing/vestibular/ear.

Disease Ontology:11 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia:69 Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes... more...

Related Diseases for Cauda Equina Syndrome

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Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to cauda equina syndrome

Symptoms for Cauda Equina Syndrome

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UMLS symptoms related to Cauda Equina Syndrome:


edema of spinal cord, radicular pain, pain in spine

Drugs & Therapeutics for Cauda Equina Syndrome

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Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Procaine4759-46-14914
Synonyms:
.beta.-(Diethylamino)ethyl p-aminobenzoate
.beta.-Diethylaminoethyl 4-aminobenzoate
2-(Diethylamino)ethyl 4-aminobenzoate
2-(Diethylamino)ethyl p-aminobenzoate
2-(Diethylamino)ethyl-4-aminobenzoate
2-Diethylaminoethyl 4-aminobenzoate
2-Diethylaminoethyl p-aminobenzoate
2-Diethylaminoethylester kyseliny p-aminobenzoove
2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]
4-14-00-01138 (Beilstein Handbook Reference)
4-Aminobenzoesaeure-beta-diethylaminoethylester
4-Aminobenzoic acid 2-(diethylamino) ethyl ester
4-Aminobenzoic acid 2-diethylaminoethyl ester
4-Aminobenzoic acid diethylaminoethyl ester
59-46-1
91484-72-9
AB00053531
AC1L1J8C
AC1Q2ZE2
AKOS000115407
Allocaine
Anticort
Anticort (TM)
Anuject
BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE
BPBio1_000179
BRD-K24616672-003-05-2
BRN 0913480
BSPBio_000161
BSPBio_002231
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester
Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
C07375
CAS-51-05-8
CHEBI:8430
CHEMBL569
CID4914
D08422
DB00721
Diethylaminoethyl p-aminobenzoate
DivK1c_000120
Duracaine
EINECS 200-426-9
Factor H3
Gerokit
Gerovital
Gerovital H-3
HSDB 3388
I06-1439
IDI1_000120
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
Jenacain
Jenacaine
KBio1_000120
KBio2_001318
KBio2_003886
KBio2_006454
KBio3_001731
KBioGR_000975
 
KBioSS_001318
LS-35778
Lopac-P-9879
Lopac0_000966
MolPort-000-889-177
NCGC00015864-01
NCGC00015864-02
NCGC00015864-04
NCGC00162298-01
NINDS_000120
NSC 169497
NSC169497
Nissocaine
Norocaine
Novocain
Novocaine
Prestwick0_000041
Prestwick1_000041
Prestwick2_000041
Prestwick3_000041
Procain
Procaina
Procaina [INN-Spanish]
Procaine
Procaine (INN)
Procaine HCl
Procaine [INN:BAN]
Procaine, base
Procainum
Procainum [INN-Latin]
SP-01A
SP01
SP01A
SPBio_001331
SPBio_002082
STK177303
STOCK2S-12721
Scurocaine
Solution of novocain
Solution of novocain (TN)
Spectrum2_001296
Spectrum3_000556
Spectrum4_000488
Spectrum5_001186
Spectrum_000838
Spinocaine
Stoff H3
UNII-4Z8Y51M438
Vitamin H3
WLN: ZR DVO2N2&2
beta-(Diethylamino)ethyl 4-aminobenzoate
beta-(Diethylamino)ethyl P-aminobenzoate
beta-(Diethylamino)ethyl p-aminobenzoate
beta-Diethylaminoethyl 4-aminobenzoate
p-Aminobenzoic acid 2-diethylaminoethyl ester
p-Aminobenzoyldiethylaminoethanol
p-Aminobenzyoyldiethylaminoethanol
procaine
╬▓-(diethylamino)ethyl 4-aminobenzoate
╬▓-(diethylamino)ethyl p-aminobenzoate
2
Chloroprocaine17133-16-48612
Synonyms:
133-16-4
2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate
2-(Diethylaminoethyl)-4-amino-2-chlorobenzoate
2-Chloroprocaine
2-diethylaminoethyl 4-amino-2-chlorobenzoate
3858-89-7 (hydrochloride)
4-14-00-01273 (Beilstein Handbook Reference)
4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester
4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
AC1L1RCM
BRN 2808071
Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester
C07877
C13H19ClN2O2
CHEBI:3636
CHLOROPROCAINE
CID8612
Chlor-procaine
Chloroprocain
 
Chloroprocaine
Chloroprocaine (INN)
Chloroprocaine [INN]
Chloroprocaine hydrochloride
Chloroprocainum
Chloroprocainum [INN-Latin]
Chlorprocaine
Chlorprocainum
Cloroprocaina
Cloroprocaina [INN-Spanish]
D07678
DB01161
HSDB 3301
Halestyn
LS-35706
Nesacaine
Nesacaine MPF
Nesacaine-Ce
Piocaine
UNII-5YVB0POT2H

Interventional clinical trials:

idNameStatusNCT IDPhase
1Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)Not yet recruitingNCT02591901Phase 2
2Peristeen Bowel Irrigation System in Cauda EquinaCompletedNCT01784328
3Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal AnaesthesiaRecruitingNCT02067806
4Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated DiscEnrolling by invitationNCT00927056
5Post-void Bladder Scanning in Acute Cauda Equina SyndromeNot yet recruitingNCT02806167

Search NIH Clinical Center for Cauda Equina Syndrome


Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

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Anatomical Context for Cauda Equina Syndrome

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MalaCards organs/tissues related to Cauda Equina Syndrome:

34
Spinal cord, B cells, Bone, Breast, Lung, T cells, Myeloid

Animal Models for Cauda Equina Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Cauda Equina Syndrome:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1BMP2, EGR2, FOS

Publications for Cauda Equina Syndrome

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Articles related to Cauda Equina Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Lumbar subdural cerebrospinal fluid collection with acute cauda equina syndrome after posterior fossa decompression for Chiari malformation Type I: case report. (27081710)
2016
2
Cauda equina syndrome: is the current management of patients presenting to district general hospitals fit for purpose? A personal view based on a review of the literature and a medicolegal experience. (26430015)
2015
3
Giant malignant peripheral nerve sheath tumor with cauda equina syndrome and subarachnoid hemorrhage: Complications in a case of type 1 neurofibromatosis. (26283846)
2015
4
Cauda equina syndrome due to intravascular lymphoma: diagnosis by nasal biopsy. (25717092)
2015
5
Cauda Equina Syndrome in a 36 Week Gravida Patient. (26394499)
2015
6
The accuracy of clinical symptoms in detecting cauda equina syndrome in patients undergoing acute MRI of the spine. (26306934)
2015
7
Neoplastic cauda equina syndrome: a neuroimaging-based review. (26442520)
2015
8
Thoracic spinal cord compression masquerading as cauda equina syndrome: a case report. (26346050)
2015
9
Cauda equina syndrome after repeated spinal attempts: A case report and review of the literature. (25829916)
2015
10
Unusual delayed presentation of cauda equina syndrome after failed spinal anesthesia. (26240562)
2015
11
Hemorrhagic schwannoma presenting with subarachnoid hemorrhage and resulting cauda equina syndrome. (26193683)
2015
12
Cauda equina syndrome: implications for primary care. (24567588)
2014
13
Why not decompress early? The cauda equina syndrome. (24631648)
2014
14
Perirectal abscess masquerading as cauda equina syndrome in an otherwise healthy 12-year-old child. (24829842)
2014
15
In response to "Cauda equina syndrome: evaluation of clinical outcome" more insights on sexual and defecational recovery in cauda equina syndrome. (25535120)
2014
16
Intravascular large B-cell lymphoma presenting as cauda equina syndrome and showing aberrant cytokeratin expression: a diagnostic challenge. (24614706)
2014
17
A complication of Artificial Urinary Sphincter: migration of pump onto the rectus sheath in a patient with cauda equina syndrome. (23893274)
2013
18
A case of the cauda equina syndrome associated with the intrathecal chemotherapy in a patient with primary central nervous system lymphoma. (23869341)
2013
19
Acute thrombosis of an abdominal aortic aneurysm presenting as cauda equina syndrome. (23063443)
2013
20
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. (23084725)
2012
21
Tandem spinal stenosis: a case of stenotic cauda equina syndrome following cervical decompression and fusion for spondylotic cervical myelopathy. (23372394)
2012
22
Cauda equina syndrome after spinal anaesthesia in a patient with asymptomatic tubercular arachnoiditis. (22013254)
2011
23
Is cauda equina syndrome being treated within the recommended time frame? (21311382)
2011
24
Cauda equina syndrome and dural ectasia: rare manifestations in chronic ankylosing spondylitis. (21606066)
2011
25
Cauda equina syndrome following combined spinal and epidural anesthesia: a case report. (21519981)
2011
26
Lumboperitoneal shunting of cerebrospinal fluid versus anti-tumor necrosis factor treatment of cauda equina syndrome in ankylosing spondylitis: comment on the article by Cornec et al. (20178129)
2010
27
Epidural cyst with cauda equina syndrome after epidural anesthesia. (20864065)
2010
28
Pediatric transverse sacral fracture with cauda equina syndrome. (20036622)
2010
29
Extramedullary-intradural spinal metastasis of small cell lung cancer causing cauda equina syndrome. (20019582)
2010
30
Cauda Equina Syndrome. (19711885)
2009
31
Cauda equina syndrome caused by a complete traumatic lumbar disc complex extrusion without alterations of facet joints. (19910776)
2009
32
Cauda equina syndrome: an anatomically driven review. (18646419)
2008
33
Cauda equina syndrome treated by lumbosacral stabilisation in a cat. (19011712)
2008
34
Cauda equina syndrome as a rare manifestation of leukemia relapse during postallograft period. (16749661)
2006
35
Postoperative cauda equina syndrome in patients undergoing single-level lumbar microdiscectomy. Report of two cases. (16122210)
2005
36
Cauda equina syndrome as a postoperative complication of lumbar spine surgery. (15202877)
2004
37
Lumbar pannus presenting as cauda equina syndrome in a patient with longstanding rheumatoid arthritis. (11296971)
2001
38
Delayed presentation of cauda equina syndrome secondary to lumbar disc herniation: functional outcomes and health-related quality of life. (17610771)
2001
39
Acute cauda equina syndrome caused by a gas-containing prolapsed intervertebral disk. (11132986)
2000
40
Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997. (10225068)
1999
41
Coccygeal fracture and Paget's disease presenting as acute cauda equina syndrome. (10195481)
1999
42
Cauda equina syndrome with elevated adenosine deaminase in a patient with HIV infection]. (8519829)
1995
43
Subarachnoid catheters and the cauda equina syndrome: hypotheses in need of trial. (8141477)
1994
44
Acute cauda equina syndrome. Diagnostic advantage of MRI. (8178242)
1994
45
Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome. (1335859)
1992
46
Glioblastoma multiforme with bone metastase and cauda equina syndrome. (2162916)
1990
47
Laminectomy for treatment of cauda equina syndrome in a cat. (3972714)
1985
48
Computerized tomography. An adjunct to early diagnosis in the cauda equina syndrome of ankylosing spondylitis. (623530)
1978
49
Cauda equina syndrome--a clinical study. (4712578)
1973
50
Cauda equina syndrome due to silent rectal carcinoma. (18138030)
1949

Variations for Cauda Equina Syndrome

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Expression for genes affiliated with Cauda Equina Syndrome

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Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for genes affiliated with Cauda Equina Syndrome

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Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6BMP2, EGR2
2
Show member pathways
9.5EGR2, FOS
39.1BMP2, EGR2, FOS

GO Terms for genes affiliated with Cauda Equina Syndrome

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Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of pri-miRNA transcription from RNA polymerase II promoterGO:190289510.1BMP2, FOS
2SMAD protein signal transductionGO:006039510.1BMP2, FOS
3skeletal muscle cell differentiationGO:00359149.8EGR2, FOS
4positive regulation of transcription, DNA-templatedGO:00458939.2BMP2, EGR2, FOS
5positive regulation of transcription from RNA polymerase II promoterGO:00459448.5BMP2, BRD4, EGR2, FOS

Molecular functions related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:00036828.9BRD4, EGR2, FOS

Sources for Cauda Equina Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet