MCID: CDQ001
MIFTS: 41

Cauda Equina Syndrome malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Cauda Equina Syndrome

Aliases & Descriptions for Cauda Equina Syndrome:

Name: Cauda Equina Syndrome 12 50 14 69
Polyradiculopathy 42 69
Cauda Equina 52

Classifications:



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Disease Ontology 12 DOID:11577
ICD10 33 G83.4
ICD9CM 35 344.6
MeSH 42 D011128
NCIt 47 C35436
UMLS 69 C0392548

Summaries for Cauda Equina Syndrome

NIH Rare Diseases : 50 cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; "foot drop"; problems with bowel and/or bladder control; and sexual dysfunction. cauda equina syndrome may be caused by a herniated disk, tumor, infection, fracture, or spinal stenosis. treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. physical therapy, occupational therapy, and/or other services may be required if symptoms persist following surgery. last updated: 5/17/2015

MalaCards based summary : Cauda Equina Syndrome, also known as polyradiculopathy, is related to cauda equina neoplasm and cauda equina intradural extramedullary astrocytoma. An important gene associated with Cauda Equina Syndrome is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways/superpathways are Adipogenesis and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Chloroprocaine and Procaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and b cells, and related phenotypes are hearing/vestibular/ear and limbs/digits/tail

Disease Ontology : 12 A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.

Wikipedia : 71 Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes... more...

Related Diseases for Cauda Equina Syndrome

Diseases related to Cauda Equina Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 cauda equina neoplasm 12.3
2 cauda equina intradural extramedullary astrocytoma 12.1
3 polyradiculopathy 12.1
4 spinal disease 11.1
5 spondylitis 10.6
6 lymphoma 10.3
7 arachnoiditis 10.3
8 spinal stenosis 10.2
9 meningitis 10.2
10 tinea corporis 10.1 BRD4 PMP22
11 thrombosis 10.1
12 b-cell lymphomas 10.1
13 lipomatosis 10.1
14 epidural abscess 10.1
15 back pain 10.1
16 denture stomatitis 10.1 BRD4 PMP22
17 chrna1-related congenital myasthenic syndrome 10.1 EGR2 PMP22
18 deafness, autosomal recessive 76 10.1 EGR2 PMP22
19 tibial nerve palsy 10.1 BRD4 PMP22
20 classic galactosemia and clinical variant galactosemia 10.1 EGR2 PMP22
21 hypertrophic osteoarthropathy, primary, autosomal recessive 2 10.0 EGR2 PMP22
22 neuropathy, inflammatory demyelinating 10.0 EGR2 PMP22
23 arachnoid cysts 10.0
24 sarcoma 10.0
25 leukemia 10.0
26 aneurysm 10.0
27 nephrolithiasis, uric acid 10.0 EGR2 PMP22
28 chkb-related muscle diseases 10.0 EGR2 PMP22
29 charcot-marie-tooth disease, type 1e 10.0 EGR2 PMP22
30 potocki-lupski syndrome 10.0 EGR2 PMP22
31 ependymoma 10.0
32 hydrocephalus 10.0
33 radiculopathy 10.0
34 spondylolisthesis 10.0
35 neuropathy, congenital hypomyelinating 9.9 EGR2 PMP22
36 wernicke-korsakoff syndrome 9.9 EGR2 PMP22
37 senile angioma 9.9 EGR2 PMP22
38 myxopapillary ependymoma 9.9
39 meningocele 9.9
40 lung cancer 9.9
41 glioblastoma 9.9
42 hemangioma 9.9
43 paget's disease of bone 9.9
44 arteriovenous malformation 9.9
45 aortic aneurysm 9.9
46 chordoma 9.9
47 abdominal aortic aneurysm 9.9
48 lipoma 9.9
49 bacterial meningitis 9.9
50 cervicitis 9.9

Graphical network of the top 20 diseases related to Cauda Equina Syndrome:



Diseases related to Cauda Equina Syndrome

Symptoms & Phenotypes for Cauda Equina Syndrome

MGI Mouse Phenotypes related to Cauda Equina Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.26 BMP2 EGR2 FOS PMP22
2 limbs/digits/tail MP:0005371 8.92 BMP2 EGR2 FOS PMP22

Drugs & Therapeutics for Cauda Equina Syndrome

Drugs for Cauda Equina Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chloroprocaine Approved 133-16-4 8612
2
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
3 Anesthetics
4 Anesthetics, Local
5 Central Nervous System Depressants
6 Peripheral Nervous System Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Not yet recruiting NCT02591901 Phase 2
2 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056
3 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
4 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806
5 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Not yet recruiting NCT02806167

Search NIH Clinical Center for Cauda Equina Syndrome

Cochrane evidence based reviews: polyradiculopathy

Genetic Tests for Cauda Equina Syndrome

Anatomical Context for Cauda Equina Syndrome

MalaCards organs/tissues related to Cauda Equina Syndrome:

39
Spinal Cord, Bone, B Cells, Lung, Breast, T Cells, Myeloid

Publications for Cauda Equina Syndrome

Articles related to Cauda Equina Syndrome:

(show top 50) (show all 520)
id Title Authors Year
1
Cauda equina syndrome caused by filum terminale lipoma: magnetic resonance imaging features and surgical treatment. ( 28444101 )
2017
2
Contained ruptured abdominal aortic aneurysm presenting as cauda equina syndrome. ( 28062419 )
2017
3
Cauda equina syndrome secondary to lumbar disc herniation: Surgical delay and its relationship with prognosis. ( 26948511 )
2016
4
Unique Presentation of Hematometrocolpos Mimicking Cauda Equina Syndrome: Severe Back Pain and Urinary Incontinence in an Adolescent Girl. ( 26924512 )
2016
5
Prevalence of thoracic spine lesions masquerading as cauda equina syndrome: yield of a novel magnetic resonance imaging protocol. ( 27815809 )
2016
6
Cauda equina syndrome. An emergency, some unexpected severe symptoms and conservative treatment. ( 27999827 )
2016
7
Cauda equina syndrome due to large B-cell lymphoma: a case report. ( 26753799 )
2016
8
Interest of isokinetic in the cauda equina syndrome. ( 27676769 )
2016
9
Time to Surgery and Outcomes in Cauda Equina Syndrome: An Analysis of 45 Cases. ( 26724637 )
2016
10
18F-FDG PET/CT Imaging of Cauda Equina Syndrome Secondary to Leptomeningeal Metastatic Breast Cancer. ( 27607169 )
2016
11
A case report of extramedullary haematopoeisis in lumbosacral region presenting as cauda equina syndrome. ( 27652196 )
2016
12
Post-hemorrhagic hydrocephalus presenting as cauda equina syndrome in a patient with spinal dysraphism. ( 26675625 )
2016
13
Comment on "Cauda equina syndrome: an uncommon cause of urinary retention in a young woman". ( 27525689 )
2016
14
Cauda equina syndrome: an uncommon cause of urinary retention in a young woman. ( 26872649 )
2016
15
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
16
Doing More with Less: Diagnostic Accuracy of CT in Suspected Cauda Equina Syndrome. ( 27789449 )
2016
17
Lumbar subdural cerebrospinal fluid collection with acute cauda equina syndrome after posterior fossa decompression for Chiari malformation Type I: case report. ( 27081710 )
2016
18
Indeterminate cauda equina syndrome: A case report. ( 26908977 )
2016
19
Impact of MR Neurography in Patients with Chronic Cauda Equina Syndrome Presenting as Chronic Pelvic Pain and Dysfunction. ( 28059708 )
2016
20
Differential diagnosis and treatment of acute cauda equina syndrome in the human immunodeficiency virus positive patient: a case report and review of the literature. ( 27268102 )
2016
21
Erratum: Management of neglected sacral fracture with cauda equina syndrome: report of two cases with review of literature. ( 28067337 )
2016
22
Impact of timing on surgical outcome in patients with cauda equina syndrome caused by lumbar disc herniation. ( 27452326 )
2016
23
Neurological Recovery in Two Patients with Cauda Equina Syndrome Secondary to L5 Lumbar Spine Giant Cell Tumour after Treatment with Denosumab without Surgery. ( 27790326 )
2016
24
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. ( 26882861 )
2016
25
Migratory low velocity intradural lumbosacral spinal bullet causing cauda equina syndrome: report of a case and review of literature. ( 27942941 )
2016
26
Intramedullary Abscess by Staphylococcus aureus Presenting as Cauda Equina Syndrome to the Emergency Department. ( 27293918 )
2016
27
Brucellar spondylodiscitis with rapidly progressive spinal epidural abscess showing cauda equina syndrome. ( 28053732 )
2016
28
Posterior Epidural Migration of a Sequestrated Lumbar Disk Fragment Causing Cauda Equina Syndrome in an Old Patient: A Case Report. ( 27257401 )
2016
29
Cauda Equina Syndrome Secondary to Leptomeningeal Carcinomatosis of Gastroesophageal Junction Cancer. ( 27239185 )
2016
30
Development of a toolkit for early identification of cauda equina syndrome. ( 27098202 )
2016
31
Percutaneous Endoscopic Lumbar Discectomy for Cauda Equina Syndrome. ( 27504566 )
2016
32
Endoscope-assisted oblique lumbar interbody fusion for the treatment of cauda equina syndrome: a technical note. ( 27924416 )
2016
33
Spinal myxopapillary ependymoma with interval drop metastasis presenting as cauda equina syndrome: case report and review of literature. ( 27757435 )
2016
34
Against the odds: extraordinary recovery from complete cauda equina syndrome following L3 fracture. Time still matters. ( 28053769 )
2016
35
Poster 227 Cauda Equina Syndrome after Lumbar Disk Herniation: A Case Report. ( 27672986 )
2016
36
Standards of care in cauda equina syndrome. ( 27240099 )
2016
37
A rare case of multiple spinal epidural abscesses and cauda equina syndrome presenting to the emergency department following acupuncture. ( 27456667 )
2016
38
Does Early Surgical Decompression in Cauda Equina Syndrome Improve Bladder Outcome?: Comments on a Recent Study by Srikandarajah et al. ( 27831995 )
2016
39
A Letter to the Editor regarding, "Time to Surgery and Outcomes in Cauda Equina Syndrome: An Analysis of 45 Cases." Critique of Bydon et al. ( 27637700 )
2016
40
Examination of The Predictive Power of Electromyography and Urodynamic Study in Patients with Cauda Equina Syndrome (Horse Tail Syndrome). ( 28077887 )
2016
41
Primary Ewing sarcoma of the lumbar spine presenting as cauda equina syndrome in a pediatric patient. ( 26882852 )
2016
42
Hemorrhagic schwannoma presenting with subarachnoid hemorrhage and resulting cauda equina syndrome. ( 26193683 )
2015
43
A Rare Cause of Cauda Equina Syndrome by Infiltration: Case of a Sacral Chordoma. ( 26096413 )
2015
44
Neurological deterioration in cauda equina syndrome is probably progressive and continuous. Implications for clinical management. ( 26401618 )
2015
45
Documentation of Focal Neurology on Patients with Suspected Cauda Equina Syndrome and the Development of an Assessment Proforma. ( 26401161 )
2015
46
Missed Cauda Equina Syndrome after Burst Fracture of the Lumbar Spine. ( 27169089 )
2015
47
Thoracic spinal cord compression masquerading as cauda equina syndrome: a case report. ( 26346050 )
2015
48
Cauda Equina Syndrome Caused by Idiopathic Epidural Lipomatosis. ( 26834816 )
2015
49
Neoplastic cauda equina syndrome: a neuroimaging-based review. ( 26442520 )
2015
50
British Association of Spine Surgeons standards of care for cauda equina syndrome. ( 25708139 )
2015

Variations for Cauda Equina Syndrome

Expression for Cauda Equina Syndrome

Search GEO for disease gene expression data for Cauda Equina Syndrome.

Pathways for Cauda Equina Syndrome

Pathways related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.28 BMP2 EGR2
2 10.96 BMP2 EGR2 FOS
3
Show member pathways
10.84 EGR2 FOS

GO Terms for Cauda Equina Syndrome

Biological processes related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.58 BMP2 EGR2 FOS
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.46 BMP2 BRD4 EGR2 FOS
3 SMAD protein signal transduction GO:0060395 9.37 BMP2 FOS
4 myelination GO:0042552 9.32 EGR2 PMP22
5 skeletal muscle cell differentiation GO:0035914 9.26 EGR2 FOS
6 peripheral nervous system development GO:0007422 8.96 EGR2 PMP22
7 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 8.62 BMP2 FOS

Molecular functions related to Cauda Equina Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.13 BRD4 EGR2 FOS
2 RNA polymerase II activating transcription factor binding GO:0001102 8.62 EGR2 FOS

Sources for Cauda Equina Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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