MCID: CSL001
MIFTS: 33

Causalgia malady

Neuronal diseases, Rare diseases categories
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Summaries for Causalgia

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Sources:
44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and paine syndrome. An important gene associated with Causalgia is TACR1 (tachykinin receptor 1). The drugs tolazoline and tolazoline hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue.

Wikipedia:65 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Aliases & Classifications for Causalgia

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Sources:
8Disease Ontology, 44NINDS, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
causalgia:
Age of onset: Variable


Aliases & Descriptions:

causalgia 8 44 45 49 62
complex regional pain syndrome, type ii 8
complex regional pain syndrome type 2 49
causalgia nos 8


External Ids:

Disease Ontology8 DOID:3222
MeSH35 D002422
SNOMED-CT via Orphanet59 408751001
ICD10 via Orphanet26 G56.4
ICD1025 G56.4

Related Diseases for Causalgia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Causalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1reflex sympathetic dystrophy10.6
2paine syndrome10.6
3complex regional pain syndrome10.5
4amenorrhea10.3
5burns10.1
6neuronitis10.1
7dystonia10.1
8erythromelalgia10.0
9horner's syndrome10.0
10algoneurodystrophy10.0
11meningitis10.0
12chronic pain10.0
13dysautonomia10.0
14pituitary tumors10.0
15blindness10.0
16meningococcal meningitis10.0

Graphical network of diseases related to Causalgia:



Diseases related to causalgia

Symptoms for Causalgia

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Drugs & Therapeutics for Causalgia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Causalgia

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Causalgia

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Anatomical Context for Causalgia

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Sources:
33MalaCards
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MalaCards organs/tissues related to Causalgia:

33
Skin, Testes, Tongue, Pituitary, Spinal cord

Animal Models for Causalgia or affiliated genes

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Publications for Causalgia

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Sources:
52PubMed
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Articles related to Causalgia:

(show top 50)    (show all 182)
idTitleAuthorsYear
1
Causalgia: a restatement. (19927072)
2009
2
Silas Weir Mitchell, MD: the physician who discovered causalgia. (15043886)
2004
3
Great auricular causalgia: an unusual complication of excision of the submandibular gland. (14581027)
2003
4
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. (10870738)
2000
5
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. (10988302)
2000
6
Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. (10599808)
1999
7
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
8
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines. (9841007)
1998
9
Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. (9767066)
1998
10
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. (9107464)
1997
11
Lumbar sympathectomy for causalgia secondary to lumbar laminectomy. (8604835)
1996
12
Capsaicin and the cause of causalgia. (7823672)
1995
13
Reflex sympathetic dystrophy/sympathetically maintained pain/causalgia: the syndrome of neuropathic pain with dysautonomia. (7701127)
1994
14
Comparison of sympathetic neurons in orofacial and upper extremity nerves: implications for causalgia. (2358949)
1990
15
Comment on Hopkins and Charters, 'An unusual case of causalgia. Relevance to recent hypothesis on mechanism of causalgia' (Pain, 37 (1989) 93-95) (2326100)
1990
16
T2-ganglionectomy via limited costotransversectomy for minor causalgia. (2353271)
1990
17
Burning and pain after injury. Is it causalgia or reflex sympathetic dystrophy? (3340606)
1988
18
Induction of involuntary movements by peripheral trauma: an analogy with causalgia. (2876186)
1986
19
Causalgia as a complication of meningococcal meningitis. (3089364)
1986
20
Causalgia: clarifications in terminology and a case presentation. (2426328)
1986
21
Brachial plexus injuries with causalgia resulting from transaxillary rib resection. (4038064)
1985
22
Intrafascicular decompression in the treatment of causalgia with special reference to the mechanism. (3880194)
1985
23
Dental causalgia. (6942435)
1981
24
Of cardiac causalgia, Horner's syndrome, and the cardiac dermatome. (7446399)
1980
25
Facial causalgia: report of case. (6932491)
1980
26
The use of temperature biofeedback in the treatment of chronic pain due to causalgia. (476193)
1979
27
Phantom tongue pain and causalgia: case presentation and treatment. (573572)
1979
28
The causalgia syndrome treated with regional intravenous guanethidine. (756012)
1978
29
Causalgia. (710015)
1978
30
Causalgia and other reflex sympathetic dystrophies. (4701608)
1973
31
Causalgia. (4113066)
1972
32
Causalgia. (5539173)
1971
33
"Minor" causalgia. (5444499)
1970
34
Causalgia. (5359635)
1969
35
Causalgia. A case report. (13900497)
1961
36
The differentiation of causalgia and hyperpathia. (13618802)
1959
37
Causalgia: a review of 48 cases. (13223107)
1954
38
Causalgia pathogenesis and treatment. (13009495)
1952
39
The physiology of pain: abnormal neuron states in causalgia and related phenomena. (14799892)
1951
40
Causalgia. (18142024)
1949
41
Causalgia; a review of 22 cases. (18100509)
1948
42
Raynaud's Phenomenon and Atypical Causalgia; the Role of Sympathectomy. (17859117)
1948
43
Causalgia; a review. (18105061)
1948
44
Causalgia; the signs and symptoms, with particular reference to vasomotor disturbances. (18905118)
1948
45
Causalgia. (20270272)
1947
46
Causalgia of the face. (20344337)
1947
47
Causalgia. (20270995)
1947
48
Causalgia; its etiology, diagnosis and treatment with tetra-ethyl-ammonium chloride (etamon chloride). (20267441)
1947
49
Genitofemoral Causalgia. (20323539)
1945
50
Genitofemoral Causalgia : (A New Syndrome). (20322413)
1942

Variations for Causalgia

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Expression for genes affiliated with Causalgia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for genes affiliated with Causalgia

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Compounds for genes affiliated with Causalgia

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GO Terms for genes affiliated with Causalgia

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Products for genes affiliated with Causalgia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Causalgia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet