MCID: CSL001
MIFTS: 34

Causalgia malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Causalgia

Aliases & Descriptions for Causalgia:

Name: Causalgia 12 51 56 52 42 14 69
Complex Regional Pain Syndrome, Type Ii 12
Complex Regional Pain Syndrome Type 2 56

Characteristics:

Orphanet epidemiological data:

56
complex regional pain syndrome type 2
Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3222
MeSH 42 D002422
NCIt 47 C121572
Orphanet 56 ORPHA99994
ICD10 via Orphanet 34 G56.4
ICD10 33 G56.4
UMLS 69 C0007462

Summaries for Causalgia

NINDS : 51 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

MalaCards based summary : Causalgia, also known as complex regional pain syndrome, type ii, is related to complex regional pain syndrome and reflex sympathetic dystrophy, and has symptoms including neuralgia and sciatica. An important gene associated with Causalgia is SCN11A (Sodium Voltage-Gated Channel Alpha Subunit 11), and among its related pathways/superpathways is Neuroscience. The drugs Etoricoxib and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue, and related phenotype is Decreased centriole number.

Wikipedia : 71 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a long term... more...

Related Diseases for Causalgia

Diseases related to Causalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 11.3
2 reflex sympathetic dystrophy 10.7
3 neuronitis 9.8
4 burns 9.8
5 dystonia 9.8
6 erythromelalgia 9.7
7 meningitis 9.7
8 chronic pain 9.7
9 dysautonomia 9.7
10 pituitary tumors 9.7
11 meningococcal meningitis 9.7
12 horner's syndrome 9.7
13 biliary dyskinesia 9.7
14 pancreatitis 9.7
15 high pressure neurological syndrome 9.2 CALCA MRAS RPIA SCN11A SH3BP5

Graphical network of the top 20 diseases related to Causalgia:



Diseases related to Causalgia

Symptoms & Phenotypes for Causalgia

UMLS symptoms related to Causalgia:


neuralgia, sciatica

GenomeRNAi Phenotypes related to Causalgia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased centriole number GR00290-A 8.62 SCN11A SH3BP5

Drugs & Therapeutics for Causalgia

Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 2 202409-33-4 123619
2 Analgesics Phase 2
3 Peripheral Nervous System Agents Phase 2
4 Cyclooxygenase 2 Inhibitors Phase 2
5 Cyclooxygenase Inhibitors Phase 2
6 Analgesics, Non-Narcotic Phase 2
7 Anti-Inflammatory Agents Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 2
9 Antirheumatic Agents Phase 2
10 Adjuvants, Immunologic Phase 2
11 Neurotropin Phase 2
12 Anticonvulsants Phase 2
13
Lidocaine Approved, Vet_approved 137-58-6 3676
14
Menthol Approved 2216-51-5 16666
15 Parecoxib Approved 198470-84-7
16 Sodium Channel Blockers
17 Anesthetics
18 Diuretics, Potassium Sparing
19 Anesthetics, Local
20 Anti-Anxiety Agents
21 Anti-Arrhythmia Agents
22 Central Nervous System Depressants

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Restore Claims Characterization Study Completed NCT00200122 Phase 4
2 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
3 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
4 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2
5 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2
6 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Recruiting NCT02321566 Phase 1
7 Exposure Therapy Combined With Cortical Interventions for CRPS-II Completed NCT03174249
8 Evoked Fields After Median and Ulnar Stimulation Completed NCT00217243
9 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain Completed NCT01923285
10 Regional Anesthesia Military Battlefield Pain Outcomes Study Completed NCT00431847
11 The Efficacy of Motor Cortex Stimulation for Pain Control Completed NCT00462566
12 Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy Recruiting NCT02667717
13 Dorsal Root Ganglion Stimulation for Hand and Upper Limb Pain Recruiting NCT02553876
14 The Effect of Transcranial Direct Current Stimulation (t-DCS) On the P300 Component of Event-Related Potentials in Patients With Chronic Neuropathic Pain Due To CRPS or Diabetic Neuropathy Not yet recruiting NCT00815932
15 Efficacy of Parecoxib on Patients With CRPS No longer available NCT01523379
16 Study of Proteins Associated With Complex Regional Pain Syndrome Terminated NCT00033969

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: causalgia

Genetic Tests for Causalgia

Anatomical Context for Causalgia

MalaCards organs/tissues related to Causalgia:

39
Skin, Testes, Tongue, Pituitary, Dorsal Root Ganglion, Spinal Cord

Publications for Causalgia

Articles related to Causalgia:

(show top 50) (show all 187)
id Title Authors Year
1
Dorsal root ganglion stimulation yielded higher treatment success rate for CRPS and causalgia at 3 and 12 months: randomized comparative trial. ( 28030470 )
2016
2
From Mitchell's causalgia to complex regional pain syndromes: 150 years of definitions and theories. ( 25786040 )
2015
3
MRI findings of causalgia of the lower extremity following transsphenoidal resection of pituitary tumor. ( 23008790 )
2012
4
Causalgia: a restatement. ( 19927072 )
2009
5
The outcome of percutaneous computed tomography-guided chemical lumbar sympathectomy for patients with causalgia after lumbar discectomy. ( 17825373 )
2008
6
Mirror therapy in patients with causalgia (complex regional pain syndrome type II) following peripheral nerve injury: two cases. ( 18382828 )
2008
7
Nerve resection and re-location may relieve causalgia: a case report. ( 17869421 )
2007
8
Causalgia: an unknown contribution. ( 20503746 )
2006
9
Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. ( 16153773 )
2005
10
Reflex sympathetic dystrophy and causalgia. ( 16106603 )
2004
11
Complex regional pain syndrome: redefining reflex sympathetic dystrophy and causalgia. ( 20086409 )
2004
12
Silas Weir Mitchell, MD: the physician who discovered causalgia. ( 15043886 )
2004
13
Causalgia: a meta-analysis of the literature. ( 14609871 )
2003
14
Great auricular causalgia: an unusual complication of excision of the submandibular gland. ( 14581027 )
2003
15
The rehabilitation of causalgia (complex regional pain syndrome-type II). ( 11878079 )
2002
16
Thoracoscopic sympathectomy in causalgia. ( 11695793 )
2001
17
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. ( 10988302 )
2000
18
Sympathectomy for causalgia: experience with military injuries. ( 10963537 )
2000
19
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. ( 10870738 )
2000
20
Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. ( 10599808 )
1999
21
Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? ( 10366221 )
1999
22
Causalgia, pathological pain, and adrenergic receptors. ( 10393877 )
1999
23
Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. ( 9767066 )
1998
24
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. ( 9549444 )
1998
25
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines. ( 9841007 )
1998
26
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. ( 9841006 )
1998
27
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Terminology is outdated-1994 taxonomy should be used. ( 9732355 )
1998
28
Case report: Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. ( 9516712 )
1998
29
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. ( 9107464 )
1997
30
Algodystrophy (reflex sympathetic dystrophy syndrome) and causalgia: novel concepts regarding the nosology, pathophysiology, and pathogenesis of complex regional pain syndromes. Is the sympathetic hyperactivity hypothesis wrong? ( 9338930 )
1997
31
Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. A case report. ( 9055376 )
1997
32
Lumbar sympathectomy for causalgia secondary to lumbar laminectomy. ( 8604835 )
1996
33
Capsaicin and the cause of causalgia. ( 7823672 )
1995
34
Intravenous regional guanethidine in the treatment of reflex sympathetic dystrophy/causalgia: a randomized, double-blind study. Guanethidine Study Group. ( 7574000 )
1995
35
And still capsaicin causes causalgia. ( 7760636 )
1995
36
Reflex sympathetic dystrophy/sympathetically maintained pain/causalgia: the syndrome of neuropathic pain with dysautonomia. ( 7701127 )
1994
37
Peripheral nerve injury and causalgia secondary to routine venipuncture. ( 8190306 )
1994
38
Sympathetic maintained pain (causalgia) associated with a demonstrable peripheral-nerve lesion. Operative treatment. ( 8077268 )
1994
39
The causalgia-dystonia syndrome. ( 8353711 )
1993
40
Causalgia--reflex sympathetic dystrophy--sympathetically maintained pain: myth and reality. ( 7692292 )
1993
41
Reflex sympathetic dystrophy and causalgia. ( 1435665 )
1992
42
RSD score: criteria for the diagnosis of reflex sympathetic dystrophy and causalgia. ( 1421741 )
1992
43
Fatal posttraumatic cardiac causalgia. ( 1462928 )
1992
44
Relief of causalgia with prostaglandin E1 ointment. ( 2018228 )
1991
45
Causalgia induced by telephone-mediated lightning electrical injury and treated by interpleural block. ( 1897782 )
1991
46
T2-ganglionectomy via limited costotransversectomy for minor causalgia. ( 2353271 )
1990
47
Pain clinic #15. Treatment of sciatic nerve causalgia following pelvic fracture. ( 2367147 )
1990
48
Comment on Hopkins and Charters, 'An unusual case of causalgia. Relevance to recent hypothesis on mechanism of causalgia' (Pain, 37 (1989) 93-95) ( 2326100 )
1990
49
Comparison of sympathetic neurons in orofacial and upper extremity nerves: implications for causalgia. ( 2358949 )
1990
50
An unusual case of causalgia. Relevance to recent hypothesis on mechanism of causalgia. ( 2639665 )
1989

Variations for Causalgia

Expression for Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for Causalgia

Pathways related to Causalgia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.13 CALCA SCN11A

GO Terms for Causalgia

Sources for Causalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....