Neuronal diseases, Rare diseases categories
Aliases & Descriptions for Causalgia:
MalaCards categories: See all MalaCards categories (disease lists)
Global: Rare diseases
Anatomical: Neuronal diseases
ICD10: 28 27
Rare neurological diseases
Characteristics (Orphanet epidemiological data):51
Age of onset: All ages
NINDS:46 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.
MalaCards based summary: Causalgia, also known as complex regional pain syndrome, type ii, is related to burns and neuromuscular disease. An important gene associated with Causalgia is CALCA (Calcitonin-Related Polypeptide Alpha), and among its related pathways are NK1R-mediated Non-Apoptotic PCD and Neuroscience. The drugs tolazoline and tolazoline hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and pituitary, and related mouse phenotype behavior/neurological.
Wikipedia:68 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...
Drugs for Causalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:(show all 14)
Search NIH Clinical Center for Causalgia
Inferred drug relations via UMLS65/NDF-RT43:
MalaCards organs/tissues related to Causalgia:33
Skin, Spinal cord, Pituitary, Tongue, Testes, Dorsal root ganglion
Articles related to Causalgia:(show top 50) (show all 185)
Search GEO for disease gene expression data for Causalgia.
Cellular components related to Causalgia according to GeneCards Suite gene sharing:
Biological processes related to Causalgia according to GeneCards Suite gene sharing:(show all 23)
Molecular functions related to Causalgia according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet