MCID: CSL001
MIFTS: 36

Causalgia malady

Neuronal diseases category

Summaries for Causalgia

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and complex regional pain syndrome. An important gene associated with Causalgia is NR2E3 (nuclear receptor subfamily 2, group E, member 3). The drugs tolazoline and tolazoline hydrochloride and the compounds oxygen and cisplatin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue.

Wikipedia:63 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Aliases & Classifications for Causalgia

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Sources:
8Disease Ontology, 43NINDS, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

causalgia 8 43 44 48 60
complex regional pain syndrome, type ii 8
complex regional pain syndrome type 2 48
causalgia nos 8


External Ids:

Disease Ontology8 DOID:3222
MeSH34 D002422
SNOMED-CT via Orphanet57 408751001
ICD10 via Orphanet26 G56.4
ICD1025 G56.4

Related Diseases for Causalgia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Causalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1reflex sympathetic dystrophy10.6
2complex regional pain syndrome10.5
3amenorrhea10.3
4burns10.1
5neuronitis10.1
6blindness10.0NR2E3
7retinoblastoma10.0TACR1, NR2E3
8erythromelalgia10.0
9biliary dyskinesia10.0
10algoneurodystrophy10.0
11horner's syndrome10.0
12meningitis10.0
13pancreatitis10.0

Graphical network of diseases related to Causalgia:



Diseases related to causalgia

Clinical Features for Causalgia

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Drugs & Therapeutics for Causalgia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Causalgia

Drug clinical trials:

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Search CenterWatch for Causalgia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Causalgia

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Anatomical Context for Causalgia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Causalgia:

32
Skin, Testes, Tongue, Pituitary, Spinal cord

Animal Models for Causalgia or affiliated genes

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Publications for Causalgia

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Sources:
50PubMed
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Articles related to Causalgia:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
MRI findings of causalgia of the lower extremity following transsphenoidal resection of pituitary tumor. (23008790)
2012
2
Mirror therapy in patients with causalgia (complex regional pain syndrome type II) following peripheral nerve injury: two cases. (18382828)
2008
3
The outcome of percutaneous computed tomography-guided chemical lumbar sympathectomy for patients with causalgia after lumbar discectomy. (17825373)
2008
4
Silas Weir Mitchell, MD: the physician who discovered causalgia. (15043886)
2004
5
Reflex sympathetic dystrophy and causalgia. (16106603)
2004
6
Great auricular causalgia: an unusual complication of excision of the submandibular gland. (14581027)
2003
7
Sympathectomy for causalgia: experience with military injuries. (10963537)
2000
8
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
9
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Terminology is outdated-1994 taxonomy should be used. (9732355)
1998
10
Intravenous regional guanethidine in the treatment of reflex sympathetic dystrophy/causalgia: a randomized, double-blind study. Guanethidine Study Group. (7574000)
1995
11
The causalgia-dystonia syndrome. (8353711)
1993
12
Fatal posttraumatic cardiac causalgia. (1462928)
1992
13
RSD score: criteria for the diagnosis of reflex sympathetic dystrophy and causalgia. (1421741)
1992
14
Reflex sympathetic dystrophy and causalgia. (1435665)
1992
15
Pain clinic #15. Treatment of sciatic nerve causalgia following pelvic fracture. (2367147)
1990
16
Peripheral stimulator implant for treatment of causalgia caused by electrical burns. (3266375)
1988
17
Unilateral clubbing of fingers associated with causalgia. (3147768)
1988
18
Induction of involuntary movements by peripheral trauma: an analogy with causalgia. (2876186)
1986
19
Chronic epidural dorsal column stimulation in the treatment of causalgia pain. (6977321)
1982
20
Dental causalgia. (6942435)
1981
21
Of cardiac causalgia, Horner's syndrome, and the cardiac dermatome. (7446399)
1980
22
Deafferentation and causalgia. (6988923)
1980
23
Causalgia and other reflex sympathetic dystrophies. (4701608)
1973
24
Treatment of causalgia. Review of cases at Brooke General Hospital. (5540106)
1971
25
Causalgia. (5410601)
1970
26
Treatment of causalgia. (5819234)
1969
27
Causalgia. A review of twenty-eight treated cases. (5791040)
1969
28
Causalgia; reflex sympathetic nerve dystrophy. (5343510)
1969
29
SUCCESSFUL TREATMENT OF CAUSALGIA OF UPPER EXTREMITY WITH MEDULLARY SPINOTHALAMIC TRACTOTOMY. CASE REPORT AND REVIEW OF THE LITERATURE. (14186039)
1963
30
Causalgia. A case report. (13900497)
1961
31
Causalgia. (14484081)
1961
32
An unusual case of causalgia treated by repeated stellate ganglion block. (13795792)
1960
33
Symposium on pain mechanisms in causalgia, hyperpathia, tension states and hysteria: tension states and hysteria. (13618801)
1959
34
Causalgia; the use of ecolid (SU3088) as an adjunct in diagnosis and treatment. (13353007)
1956
35
Causalgia; evidence of the existence of crossed sensory sympathetic fibers. (13158693)
1954
36
Visceral denervation in the control of functional abdominal pain, biliary dyskinesia, chronic pancreatitis, intractable abdominal pain of organic origin and the pain due to adhesion causalgia. (15394117)
1949
37
Observations on major and minor causalgia. (18134212)
1949
38
Causalgia; the signs and symptoms, with particular reference to vasomotor disturbances. (18905118)
1948
39
Causalgia Following Gunshot Injuries of Nerves : Role of Emotional Stimuli and Surgical Cure through Interruption of Diencephalic Efferent Discharge by Sympathectomy. (17859188)
1948
40
The visious circle in causalgia. (18886383)
1948
41
Causalgia, with report of a case. (18890417)
1948
42
Causalgia. (20270272)
1947
43
Causalgia. (20270995)
1947
44
Causalgia; its etiology, diagnosis and treatment with tetra-ethyl-ammonium chloride (etamon chloride). (20267441)
1947
45
On the pathogenesis of causalgia in peripheral nerve injuries. (20261818)
1947
46
Surgical treatment of causalgia case report. (20270274)
1947
47
Causalgia secondary to injury of the major peripheral nerves; treatment by sympathectomy. (21020294)
1946
48
Causalgia. (20990698)
1946
49
Genitofemoral Causalgia. (20323539)
1945
50
Genitofemoral Causalgia : (A New Syndrome). (20322413)
1942

Genetic Variations for Causalgia

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Expression for genes affiliated with Causalgia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for genes affiliated with Causalgia

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Compounds for genes affiliated with Causalgia

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Causalgia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oxygen44 2410.3TACR1, NR2E3
2cisplatin44 49 59 1112.0TACR1, NR2E3

GO Terms for genes affiliated with Causalgia

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Products for genes affiliated with Causalgia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Causalgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet