MCID: CSL001
MIFTS: 35

Causalgia malady

Neuronal diseases, Rare diseases categories
Download this MalaCard

Summaries for Causalgia

About this section


Fully expand this MalaCard
NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards based summary: Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and complex regional pain syndrome. An important gene associated with Causalgia is TACR1 (tachykinin receptor 1). The drugs tolazoline and tolazoline hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and pituitary.

Wikipedia:65 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Aliases & Classifications for Causalgia

About this section
Sources:
8Disease Ontology, 43NINDS, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Causalgia, Aliases & Descriptions:

Name: Causalgia 8 43 44 48 62
Complex Regional Pain Syndrome, Type Ii 8
Complex Regional Pain Syndrome Type Ii 62
 
Complex Regional Pain Syndrome Type 2 48
Causalgia Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
causalgia:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:3222
MeSH34 D002422
ICD10 via Orphanet26 G56.4
ICD1025 G56.4

Related Diseases for Causalgia

About this section

Diseases related to Causalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1reflex sympathetic dystrophy10.7
2complex regional pain syndrome10.6
3amenorrhea10.3
4complex regional pain syndrome type 110.3
5burns10.2
6neuronitis10.2
7algoneurodystrophy10.0
8erythromelalgia10.0
9biliary dyskinesia10.0
10horner's syndrome10.0
11dystonia10.0
12meningitis10.0
13pancreatitis10.0
14chronic pain10.0
15dysautonomia10.0
16pituitary tumors10.0
17blindness10.0
18meningococcal meningitis10.0

Graphical network of diseases related to Causalgia:



Diseases related to causalgia

Symptoms for Causalgia

About this section

Drugs & Therapeutics for Causalgia

About this section

Drug clinical trials:

Search ClinicalTrials for Causalgia

Search NIH Clinical Center for Causalgia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Causalgia

About this section

Anatomical Context for Causalgia

About this section

MalaCards organs/tissues related to Causalgia:

32
Skin, Tongue, Pituitary, Spinal cord

Animal Models for Causalgia or affiliated genes

About this section

Publications for Causalgia

About this section

Articles related to Causalgia:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Causalgia: a restatement. (19927072)
2009
2
Silas Weir Mitchell, MD: the physician who discovered causalgia. (15043886)
2004
3
Great auricular causalgia: an unusual complication of excision of the submandibular gland. (14581027)
2003
4
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. (10870738)
2000
5
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. (10988302)
2000
6
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
7
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Stellate ganglion blockage: clinics take precautions, but few follow guidelines. (9841007)
1998
8
Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. (9767066)
1998
9
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. (9107464)
1997
10
Lumbar sympathectomy for causalgia secondary to lumbar laminectomy. (8604835)
1996
11
Capsaicin and the cause of causalgia. (7823672)
1995
12
Reflex sympathetic dystrophy/sympathetically maintained pain/causalgia: the syndrome of neuropathic pain with dysautonomia. (7701127)
1994
13
Comparison of sympathetic neurons in orofacial and upper extremity nerves: implications for causalgia. (2358949)
1990
14
Comment on Hopkins and Charters, 'An unusual case of causalgia. Relevance to recent hypothesis on mechanism of causalgia' (Pain, 37 (1989) 93-95) (2326100)
1990
15
T2-ganglionectomy via limited costotransversectomy for minor causalgia. (2353271)
1990
16
Burning and pain after injury. Is it causalgia or reflex sympathetic dystrophy? (3340606)
1988
17
Induction of involuntary movements by peripheral trauma: an analogy with causalgia. (2876186)
1986
18
Causalgia as a complication of meningococcal meningitis. (3089364)
1986
19
Causalgia: clarifications in terminology and a case presentation. (2426328)
1986
20
Brachial plexus injuries with causalgia resulting from transaxillary rib resection. (4038064)
1985
21
Intrafascicular decompression in the treatment of causalgia with special reference to the mechanism. (3880194)
1985
22
Dental causalgia. (6942435)
1981
23
Of cardiac causalgia, Horner's syndrome, and the cardiac dermatome. (7446399)
1980
24
Facial causalgia: report of case. (6932491)
1980
25
The use of temperature biofeedback in the treatment of chronic pain due to causalgia. (476193)
1979
26
Phantom tongue pain and causalgia: case presentation and treatment. (573572)
1979
27
The causalgia syndrome treated with regional intravenous guanethidine. (756012)
1978
28
Causalgia. (710015)
1978
29
Causalgia and other reflex sympathetic dystrophies. (4701608)
1973
30
Causalgia. (4113066)
1972
31
Causalgia. (5539173)
1971
32
"Minor" causalgia. (5444499)
1970
33
Causalgia. (5359635)
1969
34
Causalgia. A case report. (13900497)
1961
35
The differentiation of causalgia and hyperpathia. (13618802)
1959
36
Causalgia: a review of 48 cases. (13223107)
1954
37
Causalgia pathogenesis and treatment. (13009495)
1952
38
The physiology of pain: abnormal neuron states in causalgia and related phenomena. (14799892)
1951
39
Causalgia. (18142024)
1949
40
Visceral denervation in the control of functional abdominal pain, biliary dyskinesia, chronic pancreatitis, intractable abdominal pain of organic origin and the pain due to adhesion causalgia. (15394117)
1949
41
Causalgia; a review of 22 cases. (18100509)
1948
42
Raynaud's Phenomenon and Atypical Causalgia; the Role of Sympathectomy. (17859117)
1948
43
Causalgia; a review. (18105061)
1948
44
Causalgia; the signs and symptoms, with particular reference to vasomotor disturbances. (18905118)
1948
45
Causalgia. (20270272)
1947
46
Causalgia of the face. (20344337)
1947
47
Causalgia. (20270995)
1947
48
Causalgia; its etiology, diagnosis and treatment with tetra-ethyl-ammonium chloride (etamon chloride). (20267441)
1947
49
Genitofemoral Causalgia. (20323539)
1945
50
Genitofemoral Causalgia : (A New Syndrome). (20322413)
1942

Variations for Causalgia

About this section

Expression for genes affiliated with Causalgia

About this section
Expression patterns in normal tissues for genes affiliated with Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for genes affiliated with Causalgia

About this section

Compounds for genes affiliated with Causalgia

About this section

GO Terms for genes affiliated with Causalgia

About this section

Products for genes affiliated with Causalgia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Causalgia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet