MCID: CSL001
MIFTS: 36

Causalgia malady

Neuronal diseases category

Summaries for Causalgia

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and complex regional pain syndrome. An important gene associated with Causalgia is NR2E3 (nuclear receptor subfamily 2, group E, member 3). The drugs tolazoline and tolazoline hydrochloride and the compounds oxygen and cisplatin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue.

Wikipedia:63 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Aliases & Classifications for Causalgia

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Sources:
8Disease Ontology, 43NINDS, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

causalgia 8 43 44 48 60
complex regional pain syndrome, type ii 8
complex regional pain syndrome type 2 48
causalgia nos 8


External Ids:

Disease Ontology8 DOID:3222
MeSH34 D002422
SNOMED-CT via Orphanet57 408751001
ICD10 via Orphanet26 G56.4
ICD1025 G56.4

Related Diseases for Causalgia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Causalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1reflex sympathetic dystrophy10.6
2complex regional pain syndrome10.5
3amenorrhea10.3
4burns10.1
5neuronitis10.1
6blindness10.0NR2E3
7retinoblastoma10.0TACR1, NR2E3
8erythromelalgia10.0
9biliary dyskinesia10.0
10algoneurodystrophy10.0
11horner's syndrome10.0
12meningitis10.0
13pancreatitis10.0

Graphical network of diseases related to Causalgia:



Diseases related to causalgia

Clinical Features for Causalgia

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Drugs & Therapeutics for Causalgia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Causalgia

Drug clinical trials:

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Search CenterWatch for Causalgia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Causalgia

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Anatomical Context for Causalgia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Causalgia:

32
Skin, Testes, Tongue, Pituitary, Spinal cord

Animal Models for Causalgia or affiliated genes

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Publications for Causalgia

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Sources:
50PubMed
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Articles related to Causalgia:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
Causalgia: a restatement. (19927072)
2009
2
Thoracoscopic sympathectomy in causalgia. (11695793)
2001
3
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Terminology is outdated-1994 taxonomy should be used. (9732355)
1998
4
Sympathetic maintained pain (causalgia) associated with a demonstrable peripheral-nerve lesion. Operative treatment. (8077268)
1994
5
RSD score: criteria for the diagnosis of reflex sympathetic dystrophy and causalgia. (1421741)
1992
6
Relief of causalgia with prostaglandin E1 ointment. (2018228)
1991
7
An unusual case of causalgia. Relevance to recent hypothesis on mechanism of causalgia. (2639665)
1989
8
Burning and pain after injury. Is it causalgia or reflex sympathetic dystrophy? (3340606)
1988
9
Peripheral stimulator implant for treatment of causalgia caused by electrical burns. (3266375)
1988
10
Ketanserin and guanethidine in the treatment of causalgia. (3578868)
1987
11
Induction of involuntary movements by peripheral trauma: an analogy with causalgia. (2876186)
1986
12
A personal overview of causalgia and other reflex dystrophies. (3977427)
1985
13
The epidemiology of causalgia among soldiers wounded in Vietnam. (6406938)
1983
14
Chronic epidural dorsal column stimulation in the treatment of causalgia pain. (6977321)
1982
15
Dental causalgia. (6942435)
1981
16
Causalgia: redefinition as a clinical pain syndrome. (7267135)
1981
17
Of cardiac causalgia, Horner's syndrome, and the cardiac dermatome. (7446399)
1980
18
Facial causalgia: report of case. (6932491)
1980
19
Phantom tongue pain and causalgia: case presentation and treatment. (573572)
1979
20
Causalgia. (710015)
1978
21
Causalgia. (1124976)
1975
22
Letter: Propranolol for causalgia. (4406294)
1974
23
Causalgia. (5410601)
1970
24
Causalgia. (5359635)
1969
25
Causalgia. A centennial review. (5336504)
1967
26
SUCCESSFUL TREATMENT OF CAUSALGIA OF UPPER EXTREMITY WITH MEDULLARY SPINOTHALAMIC TRACTOTOMY. CASE REPORT AND REVIEW OF THE LITERATURE. (14186039)
1963
27
Causalgia. (13458747)
1957
28
Causalgia in the inguinogenital area. (13325097)
1956
29
Causalgia in dentistry: an abandoned pain syndrome. (13166217)
1954
30
Causalgia. (12999330)
1952
31
The physiology of pain: abnormal neuron states in causalgia and related phenomena. (14799892)
1951
32
Causalgia. (18142024)
1949
33
The use of tetra-ethyl-ammonium chloride in causalgia and livedo reticulars. (18123220)
1949
34
Observations on major and minor causalgia. (18134212)
1949
35
Raynaud's Phenomenon and Atypical Causalgia; the Role of Sympathectomy. (17859117)
1948
36
Causalgia of the ulnar nerve without motor and objective sensory disturbance. (18874287)
1948
37
Causalgia. (18103310)
1948
38
The visious circle in causalgia. (18886383)
1948
39
Causalgia. (20270995)
1947
40
Causalgia of the face; two cases successfully treated by sympathectomy. (20240904)
1947
41
Causalgia of the face. (20340570)
1947
42
Causalgia. (20239681)
1947
43
Relief of causalgia by use of tetraethylammonium chloride. (20272793)
1947
44
Causalgia; a review of its characteristics, diagnosis, and treatment. (20290617)
1947
45
Causalgia secondary to injury of the major peripheral nerves; treatment by sympathectomy. (21020294)
1946
46
Causalgia; a report on 32 cases. (20281847)
1946
47
Genitofemoral Causalgia. (20323539)
1945
48
Pain after amputation; simple stump pain; phantome sensation; causalgia. (21011871)
1945
49
MINOR CAUSALGIA FOLLOWING INJURIES AND WOUNDS. (17857842)
1941
50
A Case of Causalgia Cured by Sympathectomy. (20476013)
1934

Genetic Variations for Causalgia

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Expression for genes affiliated with Causalgia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for genes affiliated with Causalgia

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Compounds for genes affiliated with Causalgia

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Causalgia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oxygen44 2410.3TACR1, NR2E3
2cisplatin44 49 59 1112.0TACR1, NR2E3

GO Terms for genes affiliated with Causalgia

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Products for genes affiliated with Causalgia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Causalgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet