MCID: CSL001
MIFTS: 33

Causalgia malady

Neuronal category

Summaries for Causalgia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards: Causalgia, also known as complex regional pain syndrome, type ii, is related to reflex sympathetic dystrophy and n syndrome. An important gene associated with Causalgia is NR2E3 (nuclear receptor subfamily 2, group E, member 3). The drugs tolazoline and tolazoline hydrochloride and the compounds oxygen and cisplatin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and tongue.

Wikipedia:64 Complex regional pain syndrome (CRPS), formerly reflex sympathetic dystrophy (RSD) or \"causalgia\",... more...

Aliases & Classifications for Causalgia

Sources:
8Disease Ontology, 44NINDS, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

causalgia 8 44 45 49 61
complex regional pain syndrome, type ii 8
complex regional pain syndrome type 2 49
causalgia nos 8


External Ids:

Disease Ontology8 DOID:3222
MeSH35 D002422
ICD10 via Orphanet26 G56.4
ICD1025 G56.4

Related Diseases for Causalgia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Causalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1reflex sympathetic dystrophy10.6
2n syndrome10.4
3amenorrhea10.3
4chronic pain10.3
5horner's syndrome10.1
6burns10.0
7erythromelalgia10.0
8biliary dyskinesia10.0
9algoneurodystrophy10.0
10char syndrome10.0
11dysautonomia10.0
12pancreatitis, chronic10.0
13meningococcal meningitis10.0
14blindness10.0NR2E3
15retinoblastoma10.0TACR1, NR2E3

Graphical network of diseases related to Causalgia:



Diseases related to causalgia

Clinical Features for Causalgia

Drugs & Therapeutics for Causalgia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Causalgia

Drug clinical trials:

Search ClinicalTrials for Causalgia

Search NIH Clinical Center for Causalgia

Search CenterWatch for Causalgia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Causalgia

Anatomical Context for Causalgia

Sources:
33MalaCards
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MalaCards organs/tissues related to Causalgia:

33
Spinal cord, Skin, Tongue, Pituitary

Animal Models for Causalgia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Causalgia

Sources:
51PubMed
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Articles related to Causalgia:

(show top 50)    (show all 186)
idTitleAuthorsYear
1
Causalgia: a restatement. (19927072)
2009
2
The rehabilitation of causalgia (complex regional pain syndrome-type II). (11878079)
2002
3
Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. (10870738)
2000
4
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations. (10988302)
2000
5
Soleus H-reflex tests in causalgia-dystonia compared with dystonia and mimicked dystonic posture. (10599808)
1999
6
Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? (10366221)
1999
7
Case report: Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. (9516712)
1998
8
Algodystrophy (reflex sympathetic dystrophy syndrome) and causalgia: novel concepts regarding the nosology, pathophysiology, and pathogenesis of complex regional pain syndromes. Is the sympathetic hyperactivity hypothesis wrong? (9338930)
1997
9
Reflex sympathetic dystrophy/sympathetically maintained pain/causalgia: the syndrome of neuropathic pain with dysautonomia. (7701127)
1994
10
Causalgia--reflex sympathetic dystrophy--sympathetically maintained pain: myth and reality. (7692292)
1993
11
Causalgia induced by telephone-mediated lightning electrical injury and treated by interpleural block. (1897782)
1991
12
Comparison of sympathetic neurons in orofacial and upper extremity nerves: implications for causalgia. (2358949)
1990
13
Comment on Hopkins and Charters, 'An unusual case of causalgia. Relevance to recent hypothesis on mechanism of causalgia' (Pain, 37 (1989) 93-95) (2326100)
1990
14
T2-ganglionectomy via limited costotransversectomy for minor causalgia. (2353271)
1990
15
Management of causalgia after peripheral nerve injury. (2788640)
1989
16
Sympathectomy for causalgia. Patient selection and long-term results. (3579581)
1987
17
Causalgia: a wartime experience--report of twenty treated cases. (3573108)
1987
18
Mechanisms of causalgia and related clinical conditions. The role of the central and of the sympathetic nervous systems. (3730812)
1986
19
A hypothesis on the physiological basis for causalgia and related pains. (3515292)
1986
20
Brachial plexus injuries with causalgia resulting from transaxillary rib resection. (4038064)
1985
21
Iatrogenic causalgia. Classification, clinical findings, and legal ramifications. (6466157)
1984
22
Phenoxybenzamine in the treatment of causalgia. Report of 40 cases. (6726371)
1984
23
Iatrogenic causalgia. Legal implications. (6466156)
1984
24
Dental causalgia: a chronic oral pain syndrome. (6577492)
1983
25
Nerve pathophysiology and mechanisms of pain in causalgia. (6192166)
1983
26
Skin conductance, temperature, and blood flow in causalgia. (6685242)
1983
27
Facial causalgia: report of case. (6932491)
1980
28
The diagnosis and management of post-traumatic pain syndromes (causalgia). (289369)
1979
29
The causalgia syndrome treated with regional intravenous guanethidine. (756012)
1978
30
Causalgia treated by selective large fibre stimulation of peripheral nerve. (5023085)
1972
31
Cardiac causalgia. (5444308)
1970
32
Psychiatric aspects of causalgia, the phantom limb, and phantom pain. (5942780)
1966
33
CONSULTATION CLINIC: PAIN IN AN EDENTULOUS AREA MAY BE THE RESULT OF A DIFFICULT EXTRACTION. PERHAPS THE PATIENT HAS CAUSALGIA. (14318852)
1965
34
The differentiation of causalgia and hyperpathia. (13618802)
1959
35
Causalgia. (13458747)
1957
36
Drug therapy for causalgia. (13400010)
1957
37
The physiology of pain: abnormal neuron states in causalgia and related phenomena. (14799892)
1951
38
The management of causalgia. (14826924)
1951
39
Causalgia. (18142024)
1949
40
Raynaud's Phenomenon and Atypical Causalgia; the Role of Sympathectomy. (17859117)
1948
41
Causalgia. (18884125)
1948
42
Causalgia. (18103310)
1948
43
Causalgia; diagnosis and treatment. (18877982)
1948
44
The treatment of causalgia arising from gunshot wounds of the peripheral nerves. (20249261)
1947
45
Treatment of causalgia; an analysis of loo cases. (21018506)
1946
46
A method for the chemical production of a prolonged sympathetic paralysis; report of its use in two patients with causalgia. (20997877)
1946
47
Causalgia; a study of 75 cases. (20275218)
1946
48
MINOR CAUSALGIA FOLLOWING INJURIES AND WOUNDS. (17857842)
1941
49
THE TREATMENT OF CAUSALGIA BY THORACIC SYMPATHETIC GANGLIONECTOMY. (17856442)
1935
50
Median Nerve Injury; Causalgia; Alcohol Injections. (19979312)
1916

Genetic Variations for Causalgia

Expression for genes affiliated with Causalgia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Causalgia

Search GEO for disease gene expression data for Causalgia.

Pathways for genes affiliated with Causalgia

Compounds for genes affiliated with Causalgia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 11DrugBank
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Compounds related to Causalgia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oxygen45 2410.3TACR1, NR2E3
2cisplatin45 50 60 1112.0TACR1, NR2E3

GO Terms for genes affiliated with Causalgia

Products for genes affiliated with Causalgia

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Sources for Causalgia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet