CBLC
MCID: CBL001
MIFTS: 23

Cblc (CBLC) malady

Summaries for Cblc

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32MalaCards
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MalaCards: Cblc is related to leukemia and disorders of intracellular cobalamin metabolism. An important gene associated with Cblc is MMACHC (methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria), and among its related pathways are Jak-STAT signaling pathway and PEDF Induced Signaling. The compounds Sargramostim and Adenosine monophosphate have been mentioned in the context of this disorder.

Aliases & Classifications for Cblc

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20GeneTests
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Aliases & Descriptions:

cblc 20


Related Diseases for Cblc

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cblc:



Diseases related to cblc

Clinical Features for Cblc

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Drugs & Therapeutics for Cblc

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cblc

Drug clinical trials:

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Search NIH Clinical Center for Cblc

Search CenterWatch for Cblc

Genetic Tests for Cblc

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20GeneTests
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Genetic tests related to Cblc:

id Genetic test Affiliating Genes
1 Cblc20 MMACHC

Anatomical Context for Cblc

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Animal Models for Cblc or affiliated genes

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Publications for Cblc

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Genetic Variations for Cblc

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Expression for genes affiliated with Cblc

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cblc

Search GEO for disease gene expression data for Cblc.

Pathways for genes affiliated with Cblc

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Cblc

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11DrugBank, 24HMDB, 44Novoseek
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Compounds related to Cblc according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Sargramostim1110.6IL3RA, CSF2RA
2Adenosine monophosphate11 2411.5CBLC, ITCH, UBE2I, UBE2L6
3gp 1304410.5IL3RA, IL11RA, CSF2RA
4phosphoric acid44 2411.4UBE2L6, UBE2I, ITCH, CBLC
5pyrophosphate44 2411.2CBLC, ITCH, UBE2I, UBE2L6

GO Terms for genes affiliated with Cblc

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16Gene Ontology
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Biological processes related to Cblc according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of epidermal growth factor receptor signaling pathwayGO:04205910.5SPRY2, CBLC
2negative regulation of type I interferon productionGO:03248010.4ITCH, UBE2L6
3negative regulation of MAP kinase activityGO:04340710.2SPRY2, CBLC

Molecular functions related to Cblc according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin-protein ligase activityGO:00484210.5CBLC, TRAF4, ITCH, UBE2I, UBE2L6
2cytokine receptor activityGO:00489610.2IL13RA2, IL11RA, CSF2RA

Products for genes affiliated with Cblc

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cblc

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet